Supercharge Your Innovation With Domain-Expert AI Agents!

SARS coronary virus full virus vaccine

A technology of SARS virus and whole virus, which is applied in the field of severe acute respiratory syndrome virus vaccine and its preparation, and can solve the problems of strong toxicity and strong infectious ability

Inactive Publication Date: 2005-08-03
SOUTH RES CENT NAT HUMAN GENE GROUP +1
View PDF0 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because these viruses are middle and late SARS viruses, they are highly toxic and infectious, and they are very dangerous
And because the experimental animal monkey itself is not sensitive to the SARS virus, although the vaccine produces a small reaction in the monkey, it does not mean that the safety of the middle and late SARS whole virus vaccine has been effectively verified.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • SARS coronary virus full virus vaccine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Preparation of Vaccine Using Early SARS Virus

[0040] The SARS early virus used in this embodiment is the GZ-02 virus strain, its sequence is preserved in GenBank, and the accession number is AY39556. The virus strain was purchased from the Chinese Center for Disease Control and Prevention (CDC).

[0041] Compared with TOR2, this virus strain mainly has six attenuating mutations in its nucleotide sequence: 9404→C, 17564→G, 21721→A, 22222→C, 23823→G, 27827→C.

[0042] Clinically, patients infected with this virus strain showed mild symptoms. At the same time, the infectivity is low. Therefore, this virus has good properties as an attenuated vaccine.

[0043] The virus strain was cultured in Vero, the supernatant was taken, and the purified virus was obtained by immunoaffinity chromatography. It is formulated into a vaccine with conventional adjuvants.

Embodiment 2

[0045] Evaluation of Immunized Animals with Early SARS Virus Vaccine

[0046] Rhesus macaques were immunized with the vaccine prepared in Example 1 according to conventional immunization methods.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

One kind of vaccine composition is disclosed, and the vaccine composition contains the totivirus particle of early stage SARS virus and physiologically acceptable carrier. The use of the vaccine composition in preparing SARS resisting antibody and SARS virus infection preventing medicine is also disclosed.

Description

technical field [0001] The invention relates to the field of molecular epidemiology, in particular to a vaccine against severe acute respiratory syndrome virus and a preparation method thereof. Background technique [0002] In 2003, my country and many countries in the world were attacked by a large-scale atypical pneumonia (Atypical pneumonias). Severe acute respiratory syndrome (Severe Acute Respiratory Syndrome, SARS) caused by atypical pneumonia has occurred in 22 countries and regions. The World Health Organization (WHO) quickly established a collaborative research and monitoring network consisting of 13 laboratories in 10 countries around the world after the outbreak. On April 16, WHO officially confirmed that the pathogen of SARS was a new type of coronavirus, which is a single-stranded RNA virus. [0003] There have been more than 8,000 cases of atypical pneumonia in the world, and the death rate in some diseased areas has reached 15%, which has brought great panic ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/215A61P11/00A61P31/14
CPCY02A50/30
Inventor 赵国屏林锦炎宋怀东郑焕英王升跃何剑峰任双喜鄢心革李亦学万卓越孔祥银许锐恒郝沛吴新伟顾伯伟侯金林陈竺闵军缪有刚徐军傅刚陆家海张树义王小宁
Owner SOUTH RES CENT NAT HUMAN GENE GROUP
Features
  • R&D
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More