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Degradable biomedicine composite material in nanometer structure and its prepn process

A nanostructure, biomedical technology, applied in medical science, prosthesis, etc., can solve the problems of X-ray non-development, aseptic inflammatory reaction, large calcium phosphate particle size, etc. The effect of simple conditions and easy industrialization

Inactive Publication Date: 2005-09-28
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this type of degradable material also has many shortcomings: after the material is implanted in the body, X-rays do not develop, and the implantation cannot be effectively detected; as the degradation time increases, the mechanical properties of this type of material decrease too quickly; during the degradation process Acidic substances produced in the
However, there are still differences between the structure of these composite materials and the structure of bone tissue: the main reason is that the particle size of calcium phosphate is relatively large (the calcium phosphate in bones is tens of nanometers, while their calcium phosphate is 1-100 μm). The degradation performance of the material is not good enough, and the dispersion of inorganic substances in the polymer matrix is ​​not uniform enough
The above invention cannot effectively adjust the degradation rate of the composite material to meet the requirements of different implantation sites for the degradation rate of the implant

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Add 1g of nanostructured apatite / β-phase tricalcium phosphate composite powder into 400ml of tetrahydrofuran, ultrasonically oscillate for 15 minutes, add 7.2g of polylactic acid, dissolve it under magnetic stirring at 50°C, ultrasonicate it, and cast it on a Form a thin film in a 38mm mold, dry it at 40°C for 24 hours, and then put it in a vacuum drying oven until the quality of the film is constant. The content of the obtained apatite / β-phase tricalcium phosphate composite powder is 12.2 The wt% calcium phosphate / polylactic acid composite material was put into a desiccator for refrigeration.

Embodiment 2

[0043] Add 2g of nanostructured apatite / α-phase tricalcium phosphate composite powder into 1500ml of dimethylformamide, ultrasonically oscillate for 15 minutes, then add 38g of polycaprolactone, dissolve with magnetic stirring at 50°C and then ultrasonicate Afterwards, cast it in a mold with a diameter of 38mm to form a film, dry it at 160°C for 24 hours, and then put it into a vacuum drying oven for vacuum drying until the quality of the film is constant. The obtained α-phase tricalcium phosphate content is 5wt% The calcium phosphate / polycaprolactone composite was refrigerated in a desiccator.

Embodiment 3

[0045] Add 1g of nanostructured α-phase tricalcium phosphate / β-phase tricalcium phosphate composite powder into 300ml of dimethyl sulfoxide, ultrasonically oscillate for 15 minutes, then add 4g of polylactic acid, dissolve with magnetic stirring at 50°C and then ultrasonicate Finally, cast it into a film with a diameter of 38mm, dry it at 160°C for 24 hours, and put it in a vacuum drying oven until the quality of the film is constant. The obtained α-phase tricalcium phosphate composite powder / β The calcium phosphate / polylactic acid composite material with a tricalcium phosphate composite powder content of 20 wt% is placed in a desiccator for refrigeration.

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Abstract

The composite material consists of calcium phosphate powder in nanometer structure and degradable polymer, and the calcium phosphate powder in nanometer structure consists of any two of alpha phase tricalcium phosphate, beta phase tricalcium phosphate and apatite. The composite material is prepared through solution casting or non-solvent deposition to disperse the calcium phosphate powder in nanometer structure homogeneously inside the degradable polymer matrix and to reach nanometer level compounding with improved performance. The composite material may be used widely in making bone screw, bone connecting board, bone tissue and other biomedical material.

Description

technical field [0001] The invention relates to a nanostructured degradable biomedical composite material and a preparation method thereof, belonging to the technical field of preparation of biomedical substitute materials. Background technique [0002] Due to diseases or trauma, hard tissues such as human bones or teeth are damaged or lost, and a large number of artificial synthetic substitute materials are needed for repair and treatment. At present, hard tissue replacement materials mainly include three types of materials: metals, ceramics, and polymers. They each have their own characteristics. [0003] Metal materials have high strength and are easy to process. However, the price is expensive, and it does not match the bone stress, which will cause bone tissue resorption, and the metal ions produced by physiological corrosion will have adverse reactions to the tissue, and such materials need a second operation to remove after the tissue heals. [0004] Calcium phosph...

Claims

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Application Information

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IPC IPC(8): A61L27/42A61L27/44A61L27/58
Inventor 翁文剑李延报韩高荣杜丕一程逵沈鸽赵高凌张溪文
Owner ZHEJIANG UNIV