Unlock instant, AI-driven research and patent intelligence for your innovation.

Composition for treating inflammation which contains zinc pyrrolidonecarboxylate

A technology of zinc pyrrolidone carboxylate and inhibitors, which is applied in the field of inflammation inhibitors, and can solve the problems of insufficient effect, insoluble in water, insoluble in oily ingredients, etc.

Active Publication Date: 2011-04-27
AJINOMOTO CO INC
View PDF5 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these compounds are poorly soluble in both water and oil-based ingredients, and are difficult to use as ingredients in cosmetics and external skin medicines, and their effects are insufficient.
In addition, these substances have not been reported to inhibit the activation of gene transcription factors such as AP-1, which is an important element of inflammation caused by ultraviolet rays
As a zinc-related substance, zinc oxide has been reported to suppress diaper rash (for example, Non-Patent Document 5), but this compound is also poorly soluble in both water and oil-based ingredients, and it is difficult to use it as an ingredient in cosmetics and external skin medicines , and its effect is not sufficient
On the other hand, it has been reported that water-soluble zinc salts such as zinc acetate, for example, have the possibility of preventing arteriosclerosis by inhibiting the increased AP-1 activity when culturing vascular endothelial cells under zinc-deficient conditions (Non-Patent Document 6), but it is not known to suppress skin inflammation

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Embodiment 1 The synthesis of synthetic example PCA acid zinc salt and the synthesis of comparative substance

[0047] According to the method disclosed in the patent (Japanese Patent Application Hei 3-168240), the zinc salt of PCA acid was synthesized as follows: by reacting DL-PCA acid and zinc oxide in water at 100°C for 2 hours, and then continuing to stir at room temperature for 5 hours, the precipitated obtained by filtration of the crystals. A commercial item (Tokyo Kasei) was used as a glycine zinc salt as a comparative substance. Zinc lauricate was synthesized as follows. 250 mg (1.25 mmole) of lauric acid was dissolved in 10 mL of ethanol, and a 1% ethanol solution of zinc acetate (Wako Pure Chemical Industries) was separately prepared. 15.1 mL of this 1% zinc acetate (0.69 mmole of zinc acetate, 0.55 equivalent relative to lauric acid) was added to 10 mL of ethanol solution of lauric acid previously prepared, and the resulting precipitate was filtered. The...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention provides a composition which suppresses inflammation of the skin. The composition of the present invention contains zinc pyrrolidonecarboxylate. The composition of the present invention may be formulated as a cosmetic or any externally applied agent.

Description

technical field [0001] The present invention relates to an inflammation inhibitor useful in preventing, delaying, improving or treating inflammatory diseases or skin damage or diseases caused by inflammation. Background technique [0002] As the main factors that cause skin inflammation, there are infectious substances such as bacteria and viruses, antigenic substances that cause allergic reactions, stimuli that cause tissue damage, ultraviolet rays that cause skin cancer or promote skin aging, and the like. Due to these main factors, the skin suffers from various damages, but by suppressing the excessive inflammatory reaction which causes it, the skin damage can be reduced. [0003] In recent years, studies on the mechanism of action of skin inflammation have been conducted, and its main factors are known to be related to, for example, inflammatory cytokines called IL-1α and TNFα, and extracellular matrix-degrading enzymes such as collagenase. The expression of such cytoki...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/40A61K7/48A61P17/00A61P17/16A61P29/00A61K8/49A61K31/4015A61K31/555A61K33/30A61P39/00A61Q1/02A61Q5/00A61Q5/02A61Q17/04A61Q19/00A61Q19/08
CPCA61Q19/08A61Q5/02A61Q19/00A61K31/4015A61Q1/02A61Q19/007A61Q17/04A61Q5/00A61K8/4913A61K31/555A61P17/00A61P17/16A61P29/00A61P39/00
Inventor 岩崎敬治北泽学泷野嘉延
Owner AJINOMOTO CO INC