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Yinzhihuang tablet of oriental wormwood, cape jasmine and baicalin, and its preparing and detecting method

A technology for the determination of Yinzhihuang, which is applied in the field of traditional Chinese medicine buccal tablets for the treatment of hepatitis, can solve the problems of drug crystallization, inconvenient storage and sales of preparations, and reduced dissolution rate, etc.

Active Publication Date: 2005-12-21
LUNAN HOPE PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the particularity of the composition of the soft capsule shell, the soft capsules prepared in my country generally have serious aging phenomena. After 1.5 years of storage, the disintegration time limit generally exceeds 40 minutes, or even does not disintegrate, which brings great harm to the storage and sales of preparations. inconvenient
Long-term storage of dropping pills will also cause aging phenomena such as precipitation of drug crystals and decrease in dissolution rate.
At the same time, soft capsules and dropping pills are inconvenient for patients with dysphagia and children.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0144] Baicalin 66.7g Gardenia Extract 10.7g

[0145] Honeysuckle extract (calculated as chlorogenic acid) 13.3g Capillary extract 20g

[0146] Powdered sugar 66.42g Mannitol 44.28g

[0147] Magnesium stearate 4.428g

[0148] Grind the prescription amount of honeysuckle extract, gardenia extract, baicalin, capillary extract, and the prescription amount of powdered sugar and mannitol to make granules, add magnesium stearate, press into tablets, inspect the quality, pack, and get ready.

[0149] 1) Determination method of baicalin:

[0150] The chromatographic conditions use octadecyl bonded silica gel as the filling material, methanol-water-phosphoric acid in the ratio of 47:53:0.2 as the mobile phase, and the detection wavelength is 280nm;

[0151] Preparation of Reference Substance Solution Precisely weigh baicalin dried to constant weight and add methanol to make a solution containing 0.5 mg of baicalin per 1 ml, as the reference solution;

[0152] Preparation of the tes...

Embodiment 2

[0166] Baicalin 66.7g Gardenia Extract 10.7g

[0167] Honeysuckle extract (calculated as chlorogenic acid) 13.3g Capillary extract 20g

[0168] Powdered sugar 15.81g Mannitol 31.63g

[0169] Magnesium stearate 3.16g

[0170] Grind the prescription amount of honeysuckle extract, gardenia extract, baicalin, capillary extract, and the prescription amount of powdered sugar and mannitol to make granules, add magnesium stearate, press into tablets, quality inspection, packaging, and the product is ready.

[0171] Content determination:

[0172] 1) Determination method of baicalin:

[0173] Chromatographic conditions Use octadecyl bonded silica gel as the filling material, methanol-water-phosphoric acid in the ratio of 47:53:0.2 as the mobile phase, and the detection wavelength is 280nm;

[0174] Preparation of reference substance solution Accurately weigh the baicalin reference substance dried to constant weight and add methanol to make a solution containing 5 mg of baicalin per...

Embodiment 3

[0191] Baicalin 66.7g Gardenia Extract 10.7g

[0192] Honeysuckle extract (calculated as chlorogenic acid) 13.3g Capillary extract 20g

[0193] Powdered sugar 47.44g Mannitol 7.91g

[0194] Magnesium stearate 3.16g

[0195] Grind the prescription amount of honeysuckle extract, gardenia extract, baicalin, capillary extract, and the prescription amount of powdered sugar and mannitol to make granules, add magnesium stearate, press into tablets, quality inspection, packaging, and the product is ready.

[0196] Content determination method:

[0197] 1) Determination method of baicalin:

[0198] Chromatographic conditions Use octadecyl bonded silica gel as the filling material, methanol-water-phosphoric acid in the ratio of 47:53:0.2 as the mobile phase, and the detection wavelength is 280nm;

[0199] Preparation of reference substance solution Accurately weigh the baicalin reference substance dried to constant weight and add methanol to make a solution containing baicalin 1mg p...

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PUM

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Abstract

The present invention discloses an Yinzhihuang lozenge for effectively curing hepatitis, its preparation and detection method. It is made up by using scutellaria root extract baicalin, lonicera flower extract, gardenia fruit extract and capillaries extract as raw material.

Description

technical field [0001] The invention relates to a traditional Chinese medicine buccal tablet for treating hepatitis, specifically Yinzhihuang buccal tablet, and a preparation and detection method of the medicine. Background technique [0002] Hepatitis is a common disease worldwide, and my country is an epidemic "hardest hit area", and various types of hepatitis seriously threaten the health of Chinese people. Hepatitis C is the most common in western countries, while hepatitis B is prevalent in my country. It is predicted that there are more than 100 million people who are positive for surface antigen in my country, that is, those who are infected with hepatitis B, and there are about 30 million patients with abnormal liver function caused by hepatitis B. In addition, chronic viral hepatitis is also closely related to the occurrence of primary liver cancer, and most patients with liver cancer have a history of chronic hepatitis. Therefore, the treatment of chronic hepatit...

Claims

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Application Information

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Inventor 赵志全
Owner LUNAN HOPE PHARM CO LTD