Unlock instant, AI-driven research and patent intelligence for your innovation.

Compound salt of glycyrrhizin and kurarinol, its production and use

A technology of matrine and glycyrrhizic acid, applied in the direction of steroids, organic chemistry, etc., can solve the problems of insufficient clinical curative effect and therapeutic range

Inactive Publication Date: 2005-12-28
JIANGSU HENGRUI MEDICINE CO LTD
View PDF0 Cites 6 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to overcome the deficiency of existing single-compound glycyrrhizic acid and matrine preparations in the clinical efficacy and therapeutic range, and provide a kind of glycyrrhizic acid and matrine which is superior to any single compound in glycyrrhizic acid and matrine in the treatment of liver diseases. compound salt of ginseng

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Compound salt of glycyrrhizin and kurarinol, its production and use
  • Compound salt of glycyrrhizin and kurarinol, its production and use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Embodiment 1: Preparation of the compound salt of glycyrrhizic acid and matrine

[0024] In a 100ml reaction bottle, add 40ml of deionized water, add 2.00g (2.43mmol) of glycyrrhizinic acid and 0.686g (2.43mmol) of monohydromatrine under normal temperature and pressure, stir and dissolve, and wash the pump with water at 60°C to reduce the temperature. Concentrate under pressure (20mmHg) to a volume of 10ml, slowly add acetone dropwise under stirring, so that the precipitated white oily turbid precipitate dissolves, when the dropwise addition of acetone reaches 20ml, the precipitated white oily turbid precipitate no longer dissolves, suspend the dropwise addition of acetone, and stir until It takes about 30 minutes to 1 hour for the white oily precipitate to turn into a white solid crystal, continue to add acetone dropwise to 60ml within 30 minutes, stir in a water bath at 50°C for 1 hour, then naturally cool to room temperature and stir for 2 hours, filter, and wash with...

Embodiment 2

[0026] Example 2: Preparation of freeze-dried powder of glycyrrhizinate bimatrine compound salt

[0027] In a 100ml reaction bottle, add 2.00g (2.43mmol) of glycyrrhizic acid, 1.372g (4.86mmol) of monohydromatrine, add 30ml of deionized water, stir to dissolve, filter, and freeze-dry the filtrate to obtain 3.26g of freeze-dried powder. The yield is 99.3%.

Embodiment 3

[0028] Example 3: Preparation of freeze-dried powder of glycyrrhizic acid trimatrine compound salt

[0029] In a 100ml reaction bottle, add 2.00g (2.43mmol) of glycyrrhizinic acid, 2.06g (7.29mmol) of matrine monohydrate, add 30ml of deionized water, stir to dissolve, filter, and freeze-dry the filtrate to obtain 3.88g of freeze-dried powder. Yield 98.8%.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

Compound of glycyrrhizic acid and matrine, its production and use are disclosed. The process is carried out by reacting glycyrrhizic acid with matrine in water solution and crystallizing in different water solvent proportionally. It can be used to treat hepatopathy.

Description

technical field [0001] The invention relates to a compound salt of glycyrrhizic acid and matrine, a novel compound that can be used in medicine, a preparation method thereof, and a clinical application. Background technique [0002] Both glycyrrhizic acid and matrine are known compounds that are clinically used in the treatment of liver diseases. [0003] Glycyrrhizic acid is the active ingredient of licorice sweetness, called glycyrrhizin, and its water-soluble salt is usually used. Its main feature is that the hemolysis is very low, so it is widely used in medicine, food, cosmetics and other industries. Glycyrrhizic acid has adrenocortical hormone-like effects, can inhibit capillary permeability, and relieve the symptoms of anaphylactic shock. [0004] Glycyrrhizin can form double salts or compound preparations with various alkaloids, antibiotics, amino acids, etc., and has the effects of synergy, solubilization, and increasing drug efficacy. Ammonium salts of glycyrrhi...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C07J63/00
Inventor 孙飘扬陈永江吴玉霞
Owner JIANGSU HENGRUI MEDICINE CO LTD