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Inclusion compound of porphyrin metal complex and albumin

A clathrate and albumin technology, which is applied in the field of oxygen carriers, achieves excellent oxygen adsorption and desorption capabilities, excellent adaptability to living organisms, and easy industrial-scale manufacturing

Inactive Publication Date: 2006-08-02
NIPRO CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0015] However, even among these oxygen carriers, there is room for improvement in terms of in vivo adaptability including metabolism and manufacturing on an industrial scale.

Method used

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  • Inclusion compound of porphyrin metal complex and albumin
  • Inclusion compound of porphyrin metal complex and albumin

Examples

Experimental program
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Effect test

Embodiment 1

[0087] Manufacture of porphyrin metal complexes

[0088]2-[8-(2-methyl-1-imidazolyl) octanoyloxymethyl]- 5,10,15,20-Tetrakis[α,α,α,α-o-(1-methylcyclohexylacylamino)phenyl]porphyrin iron complex.

[0089] Inclusion of porphyrin metal complexes with albumin

[0090] Under carbon monoxide atmosphere, in 2-[8-(2-methyl-1-imidazolyl)octanoyloxymethyl]-5,10,15,20-tetra[α,α,α,α-o- (1-Methylcyclohexyl acylamino) phenyl] porphyrin iron complex (1.07mM) in 1.5L of ethanol solution, add 1.5L of 0.6M L-ascorbic acid aqueous solution for reduction, add this solution to a solution containing 0.27 mM recombinant human serum albumin (hereinafter referred to as rHSA) phosphate buffered aqueous solution (pH 7.4, 1 / 30mM) 6.5L, stirred. While adding 60L of phosphate buffer solution (pH 7.4, 1 / 30mM) to this mixture, use an ultrafiltration device (ultrafiltration membrane manufactured by Millipore: ultrafiltration molecular weight: 30,000) to perform constant-volume ultrafiltration dialysis ...

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Abstract

The invention provides a new compound and a manufacturing method of the compound, the compound utilizes metal complex which contains porphyrin to be carrier of oxygen of oxygen adsorption desorption portion, living adaptability is more excellent, and the manufacture of industrial size is simpler. The invention is a new clathrate compound which is got through utilizing albumin to include tetraphenyl porphyrin metal complex which contains 2-bit lateral chain as the indicating of the lower general formula (1). In the general formula, R1 represents substituent group which contains cyclohexyl, R2 represents substituent group, M represents transient metal atom or metal ion from the sixth to the tenth group of the periodic table of elements, X-represents halide iron, the number of X-is the number of subtracting 2 from metal ion. So a general formula (1).

Description

technical field [0001] The present invention relates to an oxygen carrier capable of reversibly absorbing and desorbing oxygen, which is used in the medical field to supply oxygen to ischemic sites or tumor tissues, for blood transfusion of patients with massive bleeding, as organ preservation perfusion fluid, and extracorporeal circulation fluid , Use of cell culture medium. [0002] More specifically, it relates to a novel compound comprising a porphyrin metal complex complexed with albumin as an oxygen adsorption-desorption site, and an oxygen carrier comprising the novel compound as an active ingredient. Background technique [0003] In order to recover patients from hemorrhagic shock, a method of replenishing plasma bulking agents with a colloid osmotic pressure almost equal to that of living blood has been conventionally used. However, when the bleeding volume of 30% or more of the circulating blood volume is accompanied by insufficient oxygen supply to the peripheral...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/555C07F15/02C07F15/06C07F11/00
CPCA61K47/48284A61K47/48961B82Y5/00A61K47/643A61K47/6949
Inventor 木田善规福富一平片山直久甲斐俊哉
Owner NIPRO CORP
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