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Polyurethane contraceptive stopping suppository

A polyurethane and suppository technology, applied in suppository delivery, female contraceptives, diseases, etc., can solve the problems of nasal mucosa irritation, central nervous system impact, skin burns, etc., and achieve good sample adaptability and environmental adaptability

Inactive Publication Date: 2006-10-25
GUANGDONG PHARMA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, studies have shown that ethylenediamine belongs to Class II (highly toxic) poisons according to GB 5044-1985 "Classification of Occupational Exposure to Toxic Hazards", (mouse percutaneous LD 50 It is 424mg / kg), volatilizes white smog, stimulates greatly to mouth, nasal mucous membrane, and direct contact with skin can cause burn; Although triethanolamine belongs to mildly hazardous substance (rat Oral LD 50 8680mg / kg), but it is also harmful to the human body after all; and the diluent acetone will have adverse effects on the central nervous system of the human body at a certain concentration

Method used

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  • Polyurethane contraceptive stopping suppository
  • Polyurethane contraceptive stopping suppository
  • Polyurethane contraceptive stopping suppository

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] 1. Raw materials

[0019] (1) Reagent: Carbodiimide-uretone modified 4,4'-diphenylmethane diisocyanate (Yantai Wanhua Polyurethane Co., Ltd.), polyoxypropylene glycol (relative molecular weight is 4500 ± 300) ( Shanghai Gaoqiao Petrochemical Company Chemical Plant No. 3), H 3 PO 4 , 10% ammonia water (self-preparation), 10% acetic acid (self-preparation), imitation human fallopian tube body fluid (phosphate physiological buffer solution with pH 7.4), polyoxypropylene tetrahydric alcohol (relative molecular weight is 400±50) (Shanghai Gao Bridge Petrochemical Company Chemical Plant No. 3).

[0020] (2) Instruments: hardness tester (Shanghai Liuling Instrument Factory), tensile device (self-made), syringe, rubber hose, porous template, etc.

[0021] 2. Preparation of PUR samples

[0022] (1) Preparation of prepolymer: Add 4,4'-diphenylmethane diisocyanate and polyoxypropylene diol (weight ratio 1:3) into the reaction kettle, and stir the reaction at a temperature of 8...

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Abstract

The present invention discloses a medical polyurethane contraceptive suppository material, including performed polymer and solidifying agent. The performed polymer is product obtained by using methylene diphenyl diisocyanate and polyoxypropylene dihydric alcohol through chemical reaction, their weight ratio is 1:2-5, the solidifying agent is polyoxypropylene tetrahydric alcohol, the weight ratio of performed polymer and solidifying agent is 1:0.01-0.3. Said invention also provides its application method.

Description

technical field [0001] The invention relates to the field of biomedical materials, in particular to a medical polyurethane contraceptive suppository material. Background technique [0002] Polyurethane has good stability, biocompatibility and anticoagulant properties, does not cause inflammation to human tissues, is resistant to biological aging, and has good physical properties, is resistant to microorganisms, can be sterilized by usual methods, and is easy to process, etc. characteristics, so it is suitable for the needs of the medical environment. In medicine, it has a wide range of uses and broad prospects, especially in the manufacture of medical supplies implanted in the human body. It has been used in artificial prosthetics, artificial organs, medical adhesives, artificial blood vessels, artificial pipes, burn dressings, contraceptive materials and Anticoagulant materials, etc. (Liu Yijun, Wang Baozhi. Application of polyurethane elastomers in medical products. Chemi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/02A61F6/06A61P15/18
Inventor 苏政权
Owner GUANGDONG PHARMA UNIV