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Process of extracting lycopdine A from plant

A kind of Huperzine A, technology, applied in the field of extraction technology of effective components of traditional Chinese medicine, can solve problems such as lack of resources

Inactive Publication Date: 2006-11-15
HENAN TALOPH PHARMACEUTICAL STOCK CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the source of huperzine A is limited to extracting from a plant called Melaleuca, and until now, the resource has been severely scarce

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Embodiment 1: take the Herba Sinensis as the new huperzine A extraction source, the technical process of the present invention is specifically operated as follows:

[0046] (1), select the Herba Sinensis to be pulverized, and be pulverized into granules,

[0047] (2), soaking: 10 kilograms of the above-mentioned pulverized Grass sinensis granules are soaked with 100 kilograms of 0.15% hydrochloric acid aqueous solution with a concentration, and the soaking time is 24 hours, and the soaking solution is obtained after soaking.

[0048] (3) Concentration under reduced pressure: pump the above soaking liquid into a concentration tank for concentration under reduced pressure, the pressure is -0.07 to -0.09Mpa, the temperature is 45-60°C, concentrate to a thin paste, release and cool,

[0049] (4), decolouring: add 0.2 kilograms of gac to the soaking liquid concentrated to thin paste, stir and decolorize, filter gac after 0.5 hour,

[0050] (5), adjust the pH value: add the ...

Embodiment 2

[0057] Embodiment 2: take the Herba Sinensis as the new huperzine A extraction source, the technical process of the present invention is specifically operated as follows:

[0058] (1), select the Herba Sinensis to be pulverized, and be pulverized into granules,

[0059] (2), soaking: 10 kilograms of the above-mentioned pulverized Grass sinensis granules are soaked in 150 kilograms of 0.25% hydrochloric acid aqueous solution with a concentration, and the soaking time is 24 hours, and the soaking solution is obtained after soaking.

[0060] (3) Concentration under reduced pressure: pump the above soaking liquid into a concentration tank for concentration under reduced pressure, the pressure is -0.07 to -0.09Mpa, the temperature is 45-60°C, concentrate to a thin paste, release and cool,

[0061] (4), decolouring: add 0.2 kilograms of gac to the soaking liquid concentrated to thin paste, stir and decolorize, filter gac after 0.5 hour,

[0062] (5), adjust the pH value: add the am...

Embodiment 3

[0069] Embodiment 3: take cedar as new huperzine A extraction source, cedar another name cedar leaf horsetail fir, the technical process concrete operation of the present invention is as follows:

[0070] (1), choose Cedar fir to pulverize, be pulverized into granular,

[0071] (2), soaking: 10 kilograms of cedar granules after the above-mentioned crushing are soaked with 100 kilograms of 0.15% hydrochloric acid aqueous solution with a concentration, and the soaking time is 24 hours, and the soaking solution is obtained after soaking.

[0072] (3) Concentration under reduced pressure: pump the above soaking liquid into a concentration tank for concentration under reduced pressure, the pressure is -0.07 to -0.09Mpa, the temperature is 45-60°C, concentrate to a thin paste, release and cool,

[0073] (4), decolouring: add 0.2 kilograms of gac to the soaking liquid concentrated to thin paste, stir and decolorize, filter gac after 0.5 hour,

[0074] (5), adjust the pH value: add t...

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PUM

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Abstract

A process for extracting huperzine A from clubmoss herb, cryptomeria, or masson fir includes such steps as breaking, immersing in acid solution, concentrating, decoloring by activated carbon, regulating pH value, extracting by chloroform, vacuum recovering, volatilizing, eluting out, vacuum recovering, crystallizing and drying.

Description

technical field [0001] The invention relates to a process for extracting effective components of traditional Chinese medicine, in particular to a process for extracting huperzine A from plants. Background technique [0002] Huperzine-A is the first reversible and potent acetylcholinesterase (AchE) inhibitor in China, and it is a new alkaloid isolated from plants. People's memory function mainly depends on a neurotransmitter called acetylcholine in the brain. When its activity is enhanced, it will promote the consolidation and maintenance of memory, and when it decreases, memory will decline or even be lost. The acetylcholinesterase present in the human body will decompose acetylcholine, making it less in the human brain and causing memory loss and dementia. Huperzine A is an inhibitor of acetylcholinesterase, which can reduce cholinesterase in the brain, thereby improving people's learning and memory abilities. It has the advantages of obvious curative effect, low toxicity...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D211/22
Inventor 刑泽田王锐李江华
Owner HENAN TALOPH PHARMACEUTICAL STOCK CO LTD
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