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Composition and apparatus for transdermal delivery

A technology of transdermal delivery and composition, which is applied in the direction of drug combination, drug delivery, pill delivery, etc., and can solve problems such as increasing the viscosity of protein or peptide preparations

Inactive Publication Date: 2007-01-24
ALZA CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These prior art materials present significant disadvantages when used to increase the viscosity of protein or peptide formulations

Method used

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  • Composition and apparatus for transdermal delivery
  • Composition and apparatus for transdermal delivery
  • Composition and apparatus for transdermal delivery

Examples

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Embodiment Construction

[0081] The following examples are provided to enable those skilled in the art to more clearly understand and practice the present invention. They should not be construed as limiting the scope of the invention, but as representative illustrations thereof.

[0082] The examples illustrate that viscosity can be increased using weak acids with peptide or protein reagents. The interaction of weak acid anions with positively charged peptides or proteins apparently leads to the formation of secondary bonds, such as hydrogen bonds, which lead to an increase in solution viscosity. The greater the number of acidic groups, the greater the number of secondary bonds formed between the anion and the peptide or protein, and therefore a greater increase in viscosity. Thus, when the monoacids, dibasic acids, tribasic acids, and tetrabasic acids are compared, the theoretical viscosity increasing capacity increases.

[0083] Parathyroid hormone (PTH) is an eighty-four amino acid polypeptide th...

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Abstract

A formulation for coating (16) a transdermal delivery device having a plurality of stratum corneum-piercing microprojections (10), the formulation comprising a bioactive agent and at least one viscosity-increasing counterion. Preferably, the formulation has a viscosity in the range of about 20-200 cp.

Description

[0001] Cross References to Related Applications [0001] This application claims the benefit of US Provisional Application No. 60 / 520,196, filed November 13,2003. field of invention [0002] The present invention generally relates to the transdermal delivery of biologically active agents. More particularly, the present invention relates to transdermal drug delivery devices and drug-containing formulations applied thereto. Background of the invention [0003] Transdermal delivery of bioactive agents or pharmaceuticals offers improvements over more traditional delivery methods such as subcutaneous injection and oral delivery. Transdermal drug delivery avoids the hepatic first-pass effect and gastrointestinal degradation of oral drug delivery. Transdermal administration also eliminates the patient discomfort, risk of infection, and invasiveness associated with subcutaneous injections. The term "transdermal", as used herein, broadly includes the delivery of an agent or drug a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B17/20A61K9/28A61K31/19A61K31/785
CPCA61K31/785A61K31/19A61M37/0015A61K38/29A61K38/25A61K9/0021A61K38/193A61K38/23A61K38/2066A61K38/215A61K38/11A61K38/212A61K38/26A61B17/205A61K38/35A61K38/24A61K38/1816A61K38/09A61K38/217A61K38/095A61P43/00A61K9/28A61K31/185
Inventor M·阿默M·J·N·科尔米尔Y·-F·马
Owner ALZA CORP