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Inclusion puerarin/cyclodextrin composition and its preparing method

A technology of cyclodextrin and puerarin, applied in the direction of drug combination, non-active ingredients of polymer compounds, medical preparations containing active ingredients, etc., can solve the problems that cannot be used in practice

Inactive Publication Date: 2007-06-13
NANJING NORMAL UNIVERSITY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention: to improve the technology of "hydroxypropyl-β-cyclodextrin compatible with puerarin" in the prior art, select among various medicinal cyclodextrins, and make it react with puerarin to form Inclusion compound, so as to greatly reduce the ratio of cyclodextrin to puerarin, improve the solubility of puerarin, so as to overcome the defect that it cannot be used in the field of medicine

Method used

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  • Inclusion puerarin/cyclodextrin composition and its preparing method
  • Inclusion puerarin/cyclodextrin composition and its preparing method
  • Inclusion puerarin/cyclodextrin composition and its preparing method

Examples

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Effect test

Embodiment 1

[0058] Example 1: Mix 0.024mol β-cyclodextrin with 135ml pure water, heat, add 0.024mol puerarin at 80°C, mix well and dissolve completely, stir for 1 hour, cool for 24 hours; filter, dry under reduced pressure, that is Obtain white solid clathrate: puerarin / cyclodextrin composition in clathrate state.

Embodiment 2

[0059] Example 2: Mix 0.024mol of hydroxypropyl-β-cyclodextrin with 27ml of pure water, heat, add 0.024mol of puerarin at 80°C, mix well and completely dissolve, stir for 1 hour, cool at 50°C to reduce Water was removed under pressure, and the solid was dried under reduced pressure to obtain a white solid clathrate.

Embodiment 3

[0060] Example 3: Mix 0.024mol β-cyclodextrin with 0.012mol hydroxypropyl-β-cyclodextrin and 45ml pure water, heat, add 0.024mol puerarin at 80°C, mix and stir for 1 hour, completely dissolve Afterwards, cool at 50°C to remove water under reduced pressure, and dry the solid under reduced pressure to obtain a white solid clathrate.

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Abstract

The present invention relates to an inclusion state puerarin / cyclodextrin composition in which the mole ratio of cyclodextrin and puerarin is 1-5:1. the described cyclodextrin can be beta-cyclodextrin or hydroxypropyl-beta-cyclodextrin or sulfo-bulyl-beta-cyclodextrin or their mixture. Besides, said invention also provides its preparation method and concrete steps.

Description

technical field [0001] The invention relates to an inclusion state puerarin / cyclodextrin composition and a preparation method of the composition. Background technique [0002] Puerarin is an isoflavone glycoside extracted and isolated from the dried root of Pueraria lobara (willd.) Ohwi, chemical name 4`, 7-dihydroxy-8-β-D-glucosyl isoflavone , molecular weight 416.38, white or slightly yellow crystalline powder, slightly soluble in ethanol, slightly soluble in water, insoluble in chloroform or ether. Studies have shown that puerarin has a significant effect on the treatment of cardiovascular and cerebrovascular diseases, especially high blood pressure and hyperlipidemia, and has little or no side effects. Puerarin has been used as a clinical drug for cardiovascular and cerebrovascular diseases. Puerarin injections are currently produced in the market Puerarin injections are likely to cause allergic reactions. In recent years, reports on the side effects of puerarin injecti...

Claims

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Application Information

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IPC IPC(8): A61K47/40A61K31/7048A61P9/12A61P3/06
Inventor 任勇董祥玉王敏孙海松
Owner NANJING NORMAL UNIVERSITY
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