Inclusion puerarin/cyclodextrin composition and its preparing method

A technology of cyclodextrin and puerarin, applied in the direction of drug combination, non-active ingredients of polymer compounds, medical preparations containing active ingredients, etc., can solve the problems that cannot be used in practice

Inactive Publication Date: 2007-06-13
NANJING NORMAL UNIVERSITY +1
View PDF8 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention: to improve the technology of "hydroxypropyl-β-cyclodextrin compatible with puerarin" in the prior art, select among various medicinal cyclodextrins, and make it react wit

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Inclusion puerarin/cyclodextrin composition and its preparing method
  • Inclusion puerarin/cyclodextrin composition and its preparing method
  • Inclusion puerarin/cyclodextrin composition and its preparing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] Example 1: Mix 0.024mol β-cyclodextrin with 135ml pure water, heat, add 0.024mol puerarin at 80°C, mix well and dissolve completely, stir for 1 hour, cool for 24 hours; filter, dry under reduced pressure, that is Obtain white solid clathrate: puerarin / cyclodextrin composition in clathrate state.

Embodiment 2

[0059] Example 2: Mix 0.024mol of hydroxypropyl-β-cyclodextrin with 27ml of pure water, heat, add 0.024mol of puerarin at 80°C, mix well and completely dissolve, stir for 1 hour, cool at 50°C to reduce Water was removed under pressure, and the solid was dried under reduced pressure to obtain a white solid clathrate.

Embodiment 3

[0060] Example 3: Mix 0.024mol β-cyclodextrin with 0.012mol hydroxypropyl-β-cyclodextrin and 45ml pure water, heat, add 0.024mol puerarin at 80°C, mix and stir for 1 hour, completely dissolve Afterwards, cool at 50°C to remove water under reduced pressure, and dry the solid under reduced pressure to obtain a white solid clathrate.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The present invention relates to an inclusion state puerarin/cyclodextrin composition in which the mole ratio of cyclodextrin and puerarin is 1-5:1. the described cyclodextrin can be beta-cyclodextrin or hydroxypropyl-beta-cyclodextrin or sulfo-bulyl-beta-cyclodextrin or their mixture. Besides, said invention also provides its preparation method and concrete steps.

Description

technical field [0001] The invention relates to an inclusion state puerarin / cyclodextrin composition and a preparation method of the composition. Background technique [0002] Puerarin is an isoflavone glycoside extracted and isolated from the dried root of Pueraria lobara (willd.) Ohwi, chemical name 4`, 7-dihydroxy-8-β-D-glucosyl isoflavone , molecular weight 416.38, white or slightly yellow crystalline powder, slightly soluble in ethanol, slightly soluble in water, insoluble in chloroform or ether. Studies have shown that puerarin has a significant effect on the treatment of cardiovascular and cerebrovascular diseases, especially high blood pressure and hyperlipidemia, and has little or no side effects. Puerarin has been used as a clinical drug for cardiovascular and cerebrovascular diseases. Puerarin injections are currently produced in the market Puerarin injections are likely to cause allergic reactions. In recent years, reports on the side effects of puerarin injecti...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K47/40A61K31/7048A61P9/12A61P3/06
Inventor 任勇董祥玉王敏孙海松
Owner NANJING NORMAL UNIVERSITY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap