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Freeze dried injection for treating cerebral apoplexy and its after-effect and its preparation method

A technology of freeze-dried powder injection and sequelae, which is applied in the field of medicine, can solve the problems of slow curative effect, long healing period, and can not meet the needs of acute and severe stroke patients, etc., and achieve the effects of fast drug effect, less chance of pollution, and long-term storage

Inactive Publication Date: 2007-07-04
刘玉辉
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The dosage forms developed on the basis of compound danshen tablets include compound danshen capsules, compound danshen granules, compound danshen oral liquid, compound danshen dripping pills, and compound danshen aerosols. Although they have definite curative effects in clinical practice, their curative effect is slow and the healing period is long. , still cannot meet the needs of acute and severe stroke patients

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Example 1: A freeze-dried powder injection for the treatment of cerebral apoplexy and its sequelae

[0038] Raw material prescription Salvia 360g Panax notoginseng 200g Borneol 6g Polysorbate-80 60g Mannitol 800g

[0039] Take Danshen medicinal material, add water and decoct three times, add 8 times the amount of water for the first time, decoct for 2 hours, add 6 times and 5 times the amount of water for the second and third times, decoct for 1.5 hours each time, combine the decoction liquid, Filtrate, concentrate the filtrate to contain 1.5-2g of medicinal materials per milliliter, add ethanol to make the alcohol content 50%, stir while adding, refrigerate and stand for 40 hours, filter, recover ethanol, concentrate to contain about 1g of medicinal materials per milliliter, Add ethanol until the alcohol content is 85%, stir while adding, refrigerate and stand for 40 hours, filter, recover ethanol, concentrate to about 1g of medicinal materials per ml, add appropriate ...

Embodiment 2

[0042] Embodiment 2: A kind of freeze-dried powder injection for the treatment of cerebral apoplexy and its sequelae

[0043] Raw material prescription Danshen 500g Panax notoginseng 250g Borneol 10g Polysorbate-8060g Mannitol 850g

[0044] Take the Danshen medicinal material, add water and decoct three times, add 6 times the amount of water for the first time, decoct for 2 hours, add 4 times the amount and 3 times the amount of water for the second and third times, decoct for 1.5 hours each time, combine the decoction liquid, Filtrate, concentrate the filtrate to contain 1.5-2g of medicinal material per milliliter, add ethanol to make the alcohol content 60%, stir while adding, refrigerate and stand for 30 hours, filter, recover ethanol, concentrate to contain about 1g of medicinal material per milliliter, Add ethanol until the alcohol content is 90%, stir while adding, refrigerate and stand for 50 hours, filter, recover ethanol, concentrate to about 1g of medicinal materials...

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PUM

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Abstract

The invention relates to a freeze dried injection for treatment of cerebral apoplexy and sequelae and process for preparation, wherein the injection comprises sodium salts of savianolic acid, Notoginsen triterpenes, baras camphor and solubilizing agent.

Description

field of invention [0001] The invention relates to the technical field of medicine, in particular to a freeze-dried powder injection for treating cerebral apoplexy and its sequelae and a preparation method thereof. Background of the invention [0002] The latest international statistics show that every 12 seconds in the world, there is one new stroke patient, and every 21 seconds, one person dies of stroke. Stroke, also known as stroke, that is, cerebrovascular disease, is roughly divided into ischemic stroke (cerebral infarction) and hemorrhagic stroke. Stroke is a common disease among middle-aged and elderly people, and its incidence increases with age. In recent years, people under the age of 40 have also suffered from stroke, and the incidence has gradually increased, and most of them have an upward trend. At present, cerebral apoplexy is raging all over the world and has become the number one killer threatening human health; the sequelae caused by cerebral apoplexy als...

Claims

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Application Information

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IPC IPC(8): A61K31/704A61K31/343A61K31/045A61K36/537A61K9/19A61P9/10A61P25/00
Inventor 刘玉辉谢瑞钢
Owner 刘玉辉