Synthetic phytase variants

Abstract

The present invention relates to a synthetic phytase comprising (a) the amino acid sequence established in SEC ID NO. 1, (b) a variant of (a) having at least 70% sequence identity with SEC ID NO. 1, or (c) a rearranged fragment, fraction, or variant of (a) or (b) that maintains phytase activity, provided that the phytase comprises one or more amino acid substitutions at one or more positions relative to SEC ID NO. 1 selected from the group consisting of: V13, T30, N37, K45, L46, T81, N83, A89, A113, Q121, Q122, A123, H128, K131, K139, A142, H143, Q162, S164, A166, S170, Q182, N184, G186, K187, L188, A194, M195, A200, I201, N202, D204, N206, K207, A209, S218, T219, L225, H228, K234, N239, E243, S248, Q256, F257, M260, S261, N270, P288, P292, A311, A314, L319, S320, W321, K344, K347, M355, L359, Q365, P367, E372, T388, Q404, and N405.