26-valent pneumococcal conjugate vaccines and methods of their use

Abstract

The invention relates to immunogenic compositions of 26 serotypes comprising 26 different conjugates of polysaccharides and carrier proteins of S. pneumoniae, wherein each conjugate comprises a polysaccharide of an S. pneumoniae serotype conjugated to a carrier protein, wherein the S. pneumoniae serotypes are as defined herein. The immunogenic compositions of 26 serotypes are useful for providing protection against S. pneumoniae infection and / or pneumococcal diseases caused by S. pneumoniae, including pneumococcal pneumonia, invasive pneumococcal disease, and acute otitis media.