Transferrin receptor binding proteins and uses thereof

Abstract

This description provides proteins comprising TfR-binding proteins, conjugates comprising such TfR-binding proteins (e.g., TfRS-dsRNA-binding protein conjugates), pharmaceutical compositions comprising TfR-binding proteins or conjugates, and methods for treating CNS diseases (e.g., neurodegenerative disease) using TfR-binding proteins or conjugates. Methods for treating or reducing pain are also included.