METHOD FOR PRODUCING A MODIFIED TOXIN POLYPEPTID
DE602022039912T2Active Publication Date: 2026-07-15CHONGQING CLARUVIS PHARM CO LTD
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Patent Information
- Application Number
- DE602022039912
- Authority / Receiving Office
- DE · DE
- Patent Type
- Patents
- Current Assignee / Owner
- Priority Date
- 2021-02-26
- Filing Date
- 2022-02-24
- Publication Date
- 2026-07-15
- Estimated Expiration
- 2042-02-24
AI Technical Summary
Technical Problem
The toxicity of toxin polypeptides necessitates the use of BL-3 environments for preparation, increasing production costs and making large-scale industrial production challenging due to safety concerns.
Method used
A method involving expressing a toxin polypeptide precursor with a specific protease cleavage site, enriching it using multiplex filtration, and activating it with proteases to reduce toxicity, allowing for safer and more efficient large-scale production without the need for isolators.
Benefits of technology
The method significantly reduces environmental and operational hazards while enhancing yield and purity, enabling high-purity toxin polypeptide production suitable for clinical applications.
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