Compositions and methods for treating a disease or disorder associated with senescence
EP4770655A1Pending Publication Date: 2026-07-08JLM EXOGRADE LLC
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Patent Information
- Authority / Receiving Office
- EP · EP
- Patent Type
- Applications
- Current Assignee / Owner
- JLM EXOGRADE LLC
- Filing Date
- 2024-08-30
- Publication Date
- 2026-07-08
AI Technical Summary
Technical Problem
Cellular senescence leads to the accumulation of senescent cells, which contribute to aging and age-related diseases, as well as adverse effects from cancer treatments, by secreting inflammatory factors and disrupting tissue function.
Method used
The use of extracellular vesicles (EVs) derived from Muse cells that encapsulate or comprise senolytic agents, promoting the selective removal of senescent cells and reversing senescence-associated phenotypes.
Benefits of technology
The described approach effectively reduces the number of senescent cells, thereby mitigating the detrimental effects of senescence on tissues and organs, and improving overall health and cosmetic appearances.
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Smart Images
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Abstract
The invention relates to compositions (e.g., pharmaceutical compositions), uses, methods, non-therapeutic and therapeutic methods related to senolytic agents encapsulated or comprised in Muse cell derived extracellular vesicles (e.g. exosomes). Such compositions and methods are useful for specifically killing senescent cells and reverting any symptoms, disorders or diseases associated with senescence.
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