Bis-[N-((5-carbamoyl)-1H-benzo[d]imidazol-2-yl)-pyrazol-5-carboxamide] derivatives and related compounds as STING (interferon gene stimulator) agonists for cancer treatment
ES3078065T3Undetermined Publication Date: 2026-09-08MERSANA THERAPEUTICS INC (100 00)
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Patent Information
- Application Number
- ES2020760644T
- Authority / Receiving Office
- ES · ES
- Patent Type
- Patents
- Current Assignee / Owner
- Priority Date
- 2020-02-28
- Filing Date
- 2020-07-31
- Publication Date
- 2026-09-08
- Estimated Expiration
- 2040-07-31
AI Technical Summary
Technical Problem
The activation of the STING pathway is often inhibited in severe disease conditions, leading to the inactivation of the STING pathway, which hampers effective cancer immune therapy and other treatments.
Method used
Development of specific compounds that modulate the activity of STING, including bis-[n-((5-carbamoyl)-1H-benzo[d]imidazol-2-yl)-pyrazol-5-carboxamide derivatives and related compounds, which act as STING agonists to stimulate the STING pathway, thereby enhancing immune responses.
Benefits of technology
These compounds effectively stimulate the STING pathway, providing therapeutic benefits in treating diseases such as cancer, inflammation, autoimmune diseases, and infectious diseases by enhancing immune activation.
✦ Generated by Eureka AI based on patent content.
Abstract
This disclosure relates to compounds of formula (IA') as STING (Interferon Gene Stimulator) agonists for use in the treatment of, for example, cancer, obesity, liver injury, sugar and lipid metabolism disorders, and viral infections. This description discloses the synthesis and characterization of exemplary compounds, as well as their pharmacological data (for example, pages 128 to 286; examples 1 to 54; tables 1, 2a, 2b, and 3). An exemplary compound is, for instance, example 1: (E)-N-(5-carbamoyl- l-(4-(5-carbamoyl-2-(4-ethyl-2-methyloxazol-5-carboxamido)-7- (3-hydroxypropoxy)-1H-benzo[d]imidazol-1-yl)but-2-en-1-yl)-7- methoxy-1H-benzo[d]imidazol-2-yl)-4-ethyl-2-methyloxazote-5- carboxamide (compound 9).
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