Therapeutic use of pleuromutilins

Abstract

A compound of formula (I) (I) where n is from 0 to 4; m is 0 or 1 with the condition that the sulfur atom and R3 are in vicinal position (if m = 0 then R3 is in position 2', and if m = 1 then R3 is in position 1'); R is ethyl or vinyl; R1 is hydrogen or (C1-6)alkyl, R2 is hydrogen or (C3-6)cycloalkyl, or (C1-6)alkyl unsubstituted, or (C1-6)alkyl substituted by one or more -hydroxy; preferably one or two, methoxy, halogen, -(C3-6)cycloalkyl, or R1 and R2 together with the nitrogen atom to which they are attached form a 5- to 7-membered heterocyclic ring containing at least 1 nitrogen atom or 1 nitrogen and 1 additional heteroatom, for example, selected from N or O, or R1 is hydroxy and R2 is formyl; R3 is OH, OR4, a halogen atom, or R3 is bonded to 2' and represents -O-(CH2)pO- with p being 2 or 3;R4 is an unsubstituted (C1-6) alkyl or (C3-6) cycloalkyl, or a pharmaceutically acceptable salt, solvate, prodrug or metabolite thereof for the specific use in the treatment or prevention of an inflammatory disease not mediated by bacteria.

Images