Malt-1 inhibitor for treating multiple myeloma

Abstract

The present invention relates to a pharmaceutical composition comprising a compound selected from the group consisting of gliptins, pharmaceutically acceptable salts thereof and hydrates thereof for use in a therapeutic or prophylactic method of treating multiple myeloma disease in a human subject in need thereof. The method according to the present invention further relates to an oral administration of said pharmaceutical composition, wherein the method results in inhibition of intracellular MALTI activity, preferably inside myeloma cells. The present invention further relates to a therapeutic or prophylactic method of treating multiple myeloma and / or use of gliptins in the manufacture of a medicament for the therapeutic or prophylactic treatment of multiple myeloma.