Implant for delivery of a drug
The drug implant with a non-erodible polymer matrix and adjustable length provides customizable and sustained drug delivery, addressing the limitations of existing systems by enabling precise dosing adjustments.
Patent Information
- Authority / Receiving Office
- HK · HK
- Patent Type
- Applications
- Current Assignee / Owner
- IMPHATEC LTD
- Filing Date
- 2026-04-01
- Publication Date
- 2026-07-10
AI Technical Summary
Existing drug delivery systems lack the ability to provide sustained and adjustable dosing of therapeutic agents, particularly in implantable devices, which are not easily customizable to meet specific patient needs.
A drug implant comprising a core with a uniformly distributed drug in a non-erodible polymer matrix, equipped with means to adjust length for predetermined dosing, and optionally featuring discrete units with a central conduit and sheath, allowing for customizable dosage adjustment.
Enables sustained and adjustable drug delivery, accommodating individual patient needs through customizable dosing, enhancing therapeutic efficacy and patient compliance.
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Abstract
Description
(12) UK Patent Application (19) GB (11) 2700644 (13) A (43) Date of A Publication 25.02.2026 (21) Application No: GB2501490.3 (22) Date of Filing: 31.01.2025 (30) Priority Data: (31) 2401392 (32) 02.02.2024 (33) GB (71) Applicant(s): Imphatec Ltd Oak Cottage, Langley Bridge, Rake, Liss, Hampshire, GU33 7JP (72) Inventor(s): William Richard Treneman, Sebastian Rhys Tharby, James Peter Catt, Nicholas Paul Harrison, Sanjukta Deb, Hassan Oliver James Morad, Caroline Lorna Erica Vaillencourt, Peter Richard van Smirren (74) Agent and / or Address for Service: Beck Greener LLP Fulwood House, 12 Fulwood Place, London, WC1V 6HR (51) INT CL: A61K9 / 00 (2006.01) A61K31 / 569 (2006.01) A61K47 / 32 (2006.01) (56) Documents Cited: US 2014 / 0221981 A1 US 2023 / 0036339 A1 WO 93 / 17662 A1 (58) Field of Search: INT CL: A61K,A61L Other: SEARCH-PATENT (54) Title of the Invention: Implant for delivery of a drug Abstract Title: Implant for the delivery of a drug (57) An implant is disclosed for the sustained delivery of a drug. The implant comprises a core comprising at least one drug distributed uniformly in a polymer matrix of a first non-erodible polymer. The implant further comprises a means for adjusting the length of the implant to provide a predetermined dosage of the at least one drug. The exterior of the implant may comprise graduated markings. The polymer may be selected from ethylene-vinyl acetate and poly(ethylmethacrylate) / n-butylmethacrylate. In one embodiment, the implant comprises of one or more discrete units, each including a drug-loaded core, a surrounding sheath made of a second non-erodible polymer, and a central coaxial conduit. These discrete units are mountable on a rod,and the total dosage is determined by the number of units assembled on the rod. Another embodiment allows for cutting the implant to adjust the length and therefore the drug dose. Also disclosed is a method for the production of the implant, a kit of parts comprising said implant and a method of producing said implant using the aforementioned kit of parts. [Figure 1B] Application GB2501490.3 Search report under Section 17 of the Patents Act 1977 Date search completed: 07 July 2025 Claims searched: 1-31 International classification Subclass and subgroup Valid from A61K31 / 569 01 / 01 / 2006 A61K47 / 32 01 / 01 / 2006 A61K9 / 00 01 / 01 / 2006 Field of search Worldwide search of patent documents classified in the following areas of the IPC: A61K, A61L Databases used in the preparation of this search report: SEARCH-PATENT Documents considered to be relevant Patent literature Category Relevant claims Document of relevance 30 X, Y X: 1-3, 5-6, 10, 13-14, 20, 23, 31 Y: 24-27 WO 93 / 17662 A1 DARATECH PTY LTD,See page 5, lines 18-29, page 7, line 4 - page 8, line 23, page 9, lines 13-29 and figure 1 X, Y X: 1-2, 5-7, 13, 21-22, 30-31 Y:24-27 US 2023 / 0036339 A1 SVIRSKIS DARREN ET AL, See page 2, paragraph 0034- 0035, page 3, paragraph 0059-0066, page 19, paragraph 0433-0437 X 1-6, 8-19, 23, 28-29, 31 US 2014 / 0221981 A1 CIMA MICHAEL J ET AL, See figures 1-3, 9, 10, page 7, paragraph 0069-0073, page 8, paragraphs 0082-0083, page 11, paragraph 0111 - page 12, paragraph 0112, examples 1-3 Non-patent literature Category Relevant claims Document of relevance Categories Letter or symbol Description X Document indicating lack of novelty or inventive step. Y Document indicating lack of inventive step,If combined with another document of the same category. & Member of the same patent family. A Document indicating technological background. 31 Letter or symbol Description P Document published on or after the priority date but before the filing date of the present application. E Earlier application published on or after the filing date of the present application. 32 Abstract discloses an implant for continuous delivery of a drug. The implant includes a core containing at least one drug uniformly distributed in a polymer matrix of a first insoluble polymer. The implant also includes means for adjusting the length of the implant to provide a predetermined dose of at least one drug. The exterior of the implant may include graduation markings. The polymer may be selected from ethylene-vinyl acetate and poly(ethyl methacrylate) / n-butyl methacrylate. In one embodiment, the implant includes one or more discrete units, each discrete unit including a drug-loaded core, a surrounding sheath made of a second non-erodible polymer, and a central coaxial conduit. These discrete units may be mounted on a rod, and the total dose is determined by the number of units assembled on the rod. Another embodiment allows the implant to be cut to adjust the length and thus adjust the drug dose. The invention also discloses a method for manufacturing an implant, comprising a component kit for the implant and a method for manufacturing the implant using the component kit.