Lipidoid compounds and related compositions and uses
Novel lipid nanoparticle compositions with specific formulations address the toxicity issues of viral vectors by providing efficient and low-toxicity nucleic acid delivery, enhancing gene therapy applications.
HK40134697APending Publication Date: 2026-07-10POSEIDA THERAPEUTICS INC
Patent Information
- Authority / Receiving Office
- HK · HK
- Patent Type
- Applications
- Current Assignee / Owner
- POSEIDA THERAPEUTICS INC
- Filing Date
- 2026-04-20
- Publication Date
- 2026-07-10
AI Technical Summary
Technical Problem
Current gene delivery and genetic modification techniques, such as viral vectors, often cause acute toxicity and harmful side effects, necessitating the development of safer and more efficient methods for delivering nucleic acids into cells.
Method used
Novel lipid nanoparticle compositions comprising specific lipid compounds, formulated with precise ratios of components like cholesterol, DOPC, DMG-PEG2000, and novel compounds of formulas (I) and (II), enable efficient and low-toxicity delivery of nucleic acids into various cell types.
Benefits of technology
The novel lipid nanoparticle compositions achieve efficient and low-toxicity delivery of nucleic acids, offering broad applicability in gene therapy and other fields by enhancing safety and efficacy.
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Smart Images
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Abstract
Compositions comprising lipid-like compounds, methods of making such compositions, and the use of these compositions in gene delivery applications are disclosed.
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