Targeted delivery ligand

The targeted delivery ligand enhances the specificity and efficacy of nucleic acid molecule delivery by forming a conjugate with the nucleic acid molecule, overcoming the challenges of non-specific binding in current delivery systems.

HK40134788APending Publication Date: 2026-07-10CHENGDU XINZELI BIOSCIENCES CO LTD
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Patent Information

Authority / Receiving Office
HK · HK
Patent Type
Applications
Current Assignee / Owner
CHENGDU XINZELI BIOSCIENCES CO LTD
Filing Date
2026-05-14
Publication Date
2026-07-10

AI Technical Summary

Technical Problem

Current targeted delivery systems for nucleic acid molecules face challenges in achieving efficient and specific delivery to target cells, particularly due to non-specific binding and low efficacy.

Method used

A targeted delivery ligand comprising a conjugate group represented by formula (X) is developed to enhance the specificity and efficacy of nucleic acid molecule delivery by forming a conjugate with the nucleic acid molecule.

Benefits of technology

The targeted delivery ligand significantly improves the specificity and efficacy of nucleic acid molecule delivery to target cells, addressing the limitations of non-specific binding in existing systems.

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Abstract

The present application provides a targeted delivery ligand, wherein the targeted delivery ligand comprises a conjugate group represented by Formula (X), or an isotopic variant, a tautomer, a stereoisomer thereof, or a mixture thereof, and a nucleic acid molecule comprising the targeted delivery ligand.
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Description

(19) State Intellectual Property Office (12) Invention Patent Application (10) Application Publication Number (43) Application Publication Date (21) Application Number 202480063482.7 (22) Application Date 2024.10.18 (66) Domestic Priority Data 202311369031.X 2023.10.20 CN (85) PCT International Application Entering National Phase Date 2026.04.01 (86) PCT International Application Application Data PCT / CN2024 / 125816 2024.10.18 (87) PCT International Application Publication Data WO2025 / 082491 ZH 2025.04.24 (71) Applicant Chengdu Xinzeli Pharmaceutical Technology Co., Ltd. Address 610219 No. 669, Phoenix Road, Chengdu Tianfu International Bio-city, Shuangliu District, Chengdu, Sichuan Province (72) Inventors: Chen Bo, Xu Jianyan, Miao Yu, Zhan Qingming, Teng Gang, Zhang Haifan, Wang Lei (74) Patent Agency: Beijing Liu Shen Law Firm, 11105 Patent Attorney: Sun Zhiguo (51) Int.Cl. C07H 15 / 04 (2006.01) A61K 31 / 7088 (2006.01) A61K 47 / 54 (2006.01) A61K 31 / 713 (2006.01) C12N 15 / 113 (2006.01) (54) Invention Title: Targeted Delivery Ligand (57) Abstract: This invention provides a targeted delivery ligand, wherein the targeted delivery ligand comprises a conjugate group represented by formula (X), or an isotopic variant, tautomer, stereoisomer, or mixture thereof, and a nucleic acid molecule containing the targeted delivery ligand. CN 122003427 A 2026.05.08 CN 1 22 00 34 27 A