Adapter and tumor electric field therapy system

Abstract

The invention provides an adapter and tumor electric field therapy, the tumor electric field therapy comprises an electrode plate, the electrode plate is provided with a flexible circuit board, a plurality of electrode units and a handshake chip used for handshake communication, and each electrode unit comprises a dielectric element and a temperature sensor with a signal end and a grounding end. The flexible circuit board is provided with multiple paths of grounding wires connected to the grounding ends and multiple paths of dual-purpose signal wires connected to the signal ends, and the dielectric elements of the electrode units are in short circuit with the signal ends. The adapter is provided with a plurality of grounding switches and a plurality of bidirectional change-over switches, each grounding wire is grounded through a corresponding grounding switch, and each dual-purpose signal wire is electrically connected with a corresponding bidirectional change-over switch. The number of the bidirectional change-over switches is greater than or equal to the number of the dual-purpose signal lines and / or the number of the grounding switches is greater than or equal to the number of the grounding lines. The bidirectional change-over switch connects the dual-purpose signal line to an AC signal line so as to transmit an AC electric signal or a detection channel of the analog-to-digital converter so as to transmit a temperature signal of each temperature sensor.

Description

(19) State Intellectual Property Office (12) Invention Patent Application (10) Application Publication Number (43) Application Publication Date (21) Application Number 202511460438.2 (22) Application Date 2024.10.25 (66) Domestic Priority Data 202311809226.1 2023.12.26 CN PCT / CN2023 / 142515 2023.12.27 CN (62) Divisional Application Data 202411499210.X 2024.10.25 (71) Applicant Jiangsu Hailai Xinchuang Medical Technology Co., Ltd. Address 214100, 7th Floor, Building 7, Area A and Area B, No. 1699 Huishan Avenue, Huishan Economic Development Zone, Wuxi City, Jiangsu Province District Applicant Hangzhou Hailai New Creation Medical Technology Co., Ltd. (72) Inventor Ying Jianjun Yu Jing Shen Qichao Hui Jiajie Zhang Jun Request to not disclose name Hu Tao (51) Int.Cl. A61N 1 / 36 (2006.01) A61N 1 / 04 (2006.01) G01K 13 / 00 (2021.01) (54) Invention Title Adapter and Tumor Electric Field Therapy System (57) Abstract This application provides an adapter and tumor electric field therapy. The tumor electric field therapy includes an electrode sheet. The electrode sheet is provided with a flexible circuit board, several electrode units and a handshake chip for handshake communication. The electrode unit includes a dielectric element and a temperature sensor with a signal terminal and a ground terminal. The flexible circuit board is provided with multiple grounding lines connected to each ground terminal and multiple dual-purpose signal lines connected to each signal terminal. The dielectric element of the electrode unit is short-circuited with the signal terminal. The adapter is equipped with multiple grounding switches and multiple bidirectional switching switches. Each grounding wire is grounded through a corresponding grounding switch, and each dual-purpose signal line is electrically connected to a corresponding bidirectional switching switch. The number of bidirectional switching switches is greater than or equal to the number of dual-purpose signal lines and / or the number of grounding switches is greater than or equal to the number of grounding wires. The bidirectional switching switches connect the dual-purpose signal lines to an AC signal line to transmit AC signals or to a detection channel of an analog-to-digital converter to transmit temperature signals from various temperature sensors. Claims (2 pages), Description (34 pages), Drawings (13 pages), CN 120983810 A, 2025.11.21, CN 1 20 98 38 10 A. 1. An adapter applied to a tumor electric field therapy system including electrode pads, characterized in that the electrode pads are provided with a flexible circuit board and a plurality of electrode units disposed on the flexible circuit board, each electrode unit including a dielectric element and a temperature sensor having a signal terminal and a ground terminal, wherein the dielectric element is short-circuited to the signal terminal of the temperature sensor; the plurality of electrode units are arranged in multiple rows and columns in the circuit, and the flexible circuit board is provided with multiple ground lines and multiple dual-purpose signal lines.The grounding terminals of each temperature sensor in the same row group are connected to the same grounding line, while the grounding terminals of each temperature sensor in different row groups are connected in parallel through different grounding lines. The signal terminals of each temperature sensor in the same column group are connected to the same dual-purpose signal line, while the signal terminals of each temperature sensor in different column groups are connected in parallel through different dual-purpose signal lines. The adapter is equipped with multiple grounding switches and multiple bidirectional switching switches corresponding to the electrode plates. The number of bidirectional switching switches is greater than or equal to the number of dual-purpose signal lines and / or the number of grounding switches is greater than or equal to the number of grounding lines. At least some of the grounding switches ground each grounding line of the electrode plate one-to-one, and at least some of the bidirectional switches are respectively connected to... Each of the dual-purpose signal lines of the electrode sheet is electrically connected. The bidirectional switching switch has an input terminal for receiving AC signals and a sampling terminal for receiving DC signals for temperature acquisition. It is configured to transmit AC signals to the dielectric element of the corresponding electrode unit via the dual-purpose signal lines when an AC signal is received at its input terminal, or to transmit DC signals to the signal terminal of the corresponding temperature sensor via the dual-purpose signal lines when a DC signal is received at its sampling terminal. When at least some of the bidirectional switching switches connected to the dual-purpose signal lines receive AC signals, all grounding switches are disconnected. When all the input terminals of the bidirectional switching switches are disconnected and at least some of the sampling terminals of the bidirectional switching switches receive DC signals, at least some of the grounding switches are individually and sequentially turned on. 2. The adapter according to claim 1, wherein the adapter has five bidirectional switching switches and four grounding switches corresponding to the electrode sheet. 3. The adapter according to claim 2, wherein the bidirectional switching switches not connected to the dual-purpose signal lines are in an idle, disconnected state. 4. The adapter according to claim 2, wherein the grounding switch not connected to the grounding wire is in an idle open state. 5. The adapter according to claim 1, wherein the electrode plate is provided with a handshake chip, the adapter sends a handshake signal to the handshake chip and receives a feedback signal from the handshake chip to determine whether it is normally connected to the electrode plate, and after normal connection with the electrode plate, configures the states of each of the grounding switches and each of the bidirectional switching switches to allow the electrode plate to be connected to an AC signal for tumor treatment or to a DC signal for temperature acquisition. 6. The adapter according to claim 5, wherein the adapter is provided with a first controller, the first controller controlling the on / off state of each of the grounding switches and the on / off state of each of the switching switches.7. The adapter according to claim 6, characterized in that the adapter receives temperature signals detected by each of the temperature sensors and converts them from analog to digital into multiple digital signals, and the first controller determines the type of the electrode plate based on the multiple digital signals. 8. The adapter according to claim 7, characterized in that the first controller determines whether the electrode plate exhibits a temperature abnormality based on the multiple digital signals. 9. A tumor electric field therapy system, characterized in that it comprises: an electric field generator providing alternating current signals; an electrode plate, the electrode plate having a flexible circuit board and a plurality of electrode units disposed on the flexible circuit board, as stated in claim 1 / 2 page 2 CN 120983810 A The electrode unit includes a dielectric element and a temperature sensor with a signal terminal and a ground terminal, wherein the dielectric element is short-circuited to the signal terminal of the temperature sensor; a plurality of electrode units are arranged in multiple rows and columns in the circuit; the flexible circuit board has multiple ground lines and multiple dual-purpose signal lines; the ground terminals of each temperature sensor in the same row group are connected to the same ground line; the ground terminals of each temperature sensor in different row groups are connected in parallel through different ground lines; the signal terminals of each temperature sensor in the same column group are connected to the same dual-purpose signal line; the signal terminals of each temperature sensor in different column groups are connected in parallel through different dual-purpose signal lines; and an adapter electrically connects the electrode plates and the electric field generator; the adapter has multiple grounding switches and multiple bidirectional switching switches corresponding to the electrode plates, wherein the number of bidirectional switching switches is greater than or equal to the number of dual-purpose signal lines and / or the number of grounding switches. The number of grounding wires is greater than or equal to the number of grounding switches; at least some of the grounding switches ground each of the grounding wires of the electrode sheet one by one; at least some of the bidirectional switches are electrically connected to each of the dual-purpose signal lines of the electrode sheet one by one; each bidirectional switch has an input terminal for receiving AC signals and a sampling terminal for receiving DC signals for temperature acquisition, and is configured to transmit AC signals to the dielectric element of the corresponding electrode unit through the dual-purpose signal lines electrically connected to it when AC signals are received at its input terminal, or to transmit DC signals to the signal terminal of the corresponding temperature sensor through the dual-purpose signal lines electrically connected to it when DC signals are received at its sampling terminal; when AC signals are received at the input terminals of at least some of the bidirectional switches, all the grounding switches are disconnected; when all the input terminals of the bidirectional switches are disconnected and DC signals are received at the sampling terminals of at least some of the bidirectional switches, at least some of the grounding switches are individually turned on sequentially. 10. The tumor electric field therapy system according to claim 9, characterized in that, the dual-purpose signal lines are not connected.The bidirectional switching switch is in an idle open state, and / or the grounding switch not connected to the grounding wire is in an idle open state. 11. The tumor electric field therapy system according to claim 9 or 10, characterized in that the adapter is provided with four grounding switches and five bidirectional switching switches corresponding to the electrode sheet. 12. The tumor electric field therapy system according to claim 9 or 10, characterized in that the electrode sheet is provided with a handshake chip, the adapter is configured to send a handshake signal to the handshake chip and receive a feedback signal from the handshake chip to determine whether it is normally connected to the electrode sheet, and after it is normally connected to the electrode sheet, configure the state of each of the grounding switches and each of the bidirectional switching switches to allow the electrode sheet to enter an AC signal for tumor treatment or to enter a DC signal for temperature acquisition. Claims 2 / 2 Page 3 CN 120983810 A Adapter and Tumor Electric Field Therapy System

[0001] This application is a divisional application filed by the applicant on October 25, 2024, with application number CN202411499210.X and invention title "Electrode Sheet, Tumor Electric Field Therapy System and Temperature Detection and Signal Control Method". Technical Field

[0002] This application relates to Tumor Treating Fields (TTF) technology, and more particularly to an adapter and a tumor electric field therapy system. Background Art

[0003] Tumor electric field therapy is a method of treating tumors by using a low-intensity, medium-to-high frequency alternating electric field to prevent the formation of spindle microtubules during the mitosis of certain tumor cells, inhibit the separation of intracellular organelles during cell division, and induce apoptosis during mitosis.

[0004] Compared with traditional cancer treatment methods, TTF has an innovative mechanism of action. Some physiological characteristics of tumor cells, such as their geometry and high-frequency mitosis, make them susceptible to TTF. TTF disrupts the normal aggregation of tubulin by applying directional forces to polar particles (such as macromolecules and organelles) within the cell. These processes may lead to physical damage to the cell membrane and apoptosis. During the telophase of mitosis, the morphology of the cleavage groove leads to uneven electric field distribution around it. Simultaneously, under the influence of TTF, the electric field strength at the cleavage groove is significantly enhanced, causing charged substances in the cell to move towards the cleavage groove, interfering with or even destroying the formation of cell structures, ultimately leading to cell division failure and apoptosis.

[0005] In existing tumor electric field therapy systems, an electric field generator transmits an alternating current signal for tumor electric field therapy to an electrode pad, which then applies an alternating electric field to the tumor site of the patient for tumor electric field therapy. When the tumor treatment electric field is applied to the patient's body, heat accumulates at the application site, and the temperature rises accordingly. Therefore, it is necessary to monitor the application site.The temperature is high, and when the temperature is too high, the electric field strength needs to be adjusted in time to avoid the risk of burns to the patient's skin.

[0006] The tumor electric field therapy system includes at least one pair of electrode pads, and each electrode pad contains multiple electrode units. Even if the same AC signal is applied to each electrode unit, the heat generated on each electrode unit will vary depending on its location. That is, the temperature of each electrode unit on the entire electrode pad will not be completely uniform. This may result in some electrode units on the entire electrode pad having a temperature exceeding the preset temperature, while the temperature of other electrode units is normal. In order to ensure that the tumor electric field therapy has a sufficiently long application time while avoiding low-temperature burns to the patient's skin, it is necessary to individually control the overheated electrode units. However, for existing electrode pads, individual control of electrode units requires setting a conductive trace for each electrode unit in the substrate of the electrode pad. This will increase the number of conductive traces in the substrate of the electrode pad, making the electrode pad difficult to bend, and the cables electrically connected to the electrode pad will also be thickened, increasing the overall weight of the electrode pad, which is not conducive to the application of the electrode pad.

[0007] Therefore, it is necessary to provide an adapter for a tumor electric field therapy system and a tumor electric field therapy system. Summary of the Invention

[0008] The purpose of this application is to provide an adapter adapted to an electrode sheet with dual-purpose signal lines and a tumor electric field therapy system.

[0009] To achieve the above objective, this application provides the following technical solution: An adapter, applied to a tumor electric field therapy system including an electrode sheet, wherein the electrode sheet is provided with a flexible circuit board and a plurality of electrode units disposed on the flexible circuit board, the electrode unit including a dielectric element and a temperature sensor having a signal terminal and a ground terminal, wherein the dielectric element is short-circuited to the signal terminal of the temperature sensor; the plurality of electrode units are arranged in multiple rows and columns in the circuit, the flexible circuit board is provided with multiple ground lines and multiple dual-purpose signal lines, the ground terminals of each temperature sensor located in the same row group are connected to the same ground line, the ground terminals of each temperature sensor located in different row groups are respectively connected in parallel through different ground lines, and the ground terminals of each temperature sensor located in the same column group are connected in parallel through different ground lines. The signal terminals of the sensors are connected to the same dual-purpose signal line, and the signal terminals of the temperature sensors located in different groups are connected in parallel through different dual-purpose signal lines. The adapter is equipped with multiple grounding switches and multiple bidirectional switching switches corresponding to the electrode plates. The number of bidirectional switching switches is greater than or equal to the number of dual-purpose signal lines and / or the number of grounding switches is greater than or equal to the number of grounding wires. At least some of the grounding switches ground each grounding wire of the electrode plate one-to-one, and at least some of the bidirectional switches are electrically connected to each dual-purpose signal line of the electrode plate one-to-one.The bidirectional switching switch has an input terminal for receiving AC signals and a sampling terminal for receiving DC signals to collect temperature data. It is configured to transmit AC signals to the dielectric element of the corresponding electrode unit via the dual-purpose signal line electrically connected to it when AC signals are received at its input terminal, or to transmit DC signals to the signal terminal of the corresponding temperature sensor via the dual-purpose signal line electrically connected to it when DC signals are received at its sampling terminal. When at least some of the input terminals of the bidirectional switching switches are connected to AC signals, all grounding switches are disconnected. When all the input terminals of the bidirectional switching switches are disconnected and at least some of the sampling terminals of the bidirectional switching switches are connected to DC signals, at least some of the grounding switches are individually and sequentially turned on.

[0010] Further, the adapter has five bidirectional switching switches and four grounding switches corresponding to the electrode plates.

[0011] Further, the bidirectional switching switches not connected to the dual-purpose signal line are in an idle / disconnected state.

[0012] Further, the grounding switches not connected to the grounding wire are in an idle / disconnected state.

[0013] Further, the electrode pad is provided with a handshake chip. The adapter sends a handshake signal to the handshake chip and receives a feedback signal from the handshake chip to determine whether it is normally connected to the electrode pad. After it is normally connected to the electrode pad, the adapter configures the states of each grounding switch and each bidirectional switching switch to allow the electrode pad to be connected to an AC signal for tumor treatment or to a DC signal for temperature acquisition.

[0014] Further, the adapter is provided with a first controller. The first controller controls the on and off states of each grounding switch and the on / off states of each switching switch.

[0015] Further, the adapter receives temperature signals detected by each temperature sensor and converts them from analog to digital signals. The first controller determines the type of the electrode pad based on the multiple digital signals.

[0016] Further, the first controller determines whether the electrode pad has a temperature abnormality based on the multiple digital signals.

[0017] This application also provides the following technical solution: a tumor electric field therapy system, characterized in that it includes: an electric field generator providing an alternating current signal; an electrode sheet, wherein the electrode sheet is provided with a flexible circuit board and a plurality of electrode units disposed on the flexible circuit board, the electrode unit including a dielectric element and a temperature sensor having a signal terminal and a ground terminal, wherein the dielectric element is short-circuited to the signal terminal of the temperature sensor; the plurality of electrode units are arranged in multiple rows and columns in the circuit, the flexible circuit board is provided with multiple ground lines and multiple dual-purpose signal lines, the ground terminals of each temperature sensor located in the same row group are connected to the same ground line, and the ground terminals of each temperature sensor located in different row groups are...The signal terminals of each temperature sensor in the same column are connected in parallel via different grounding wires. The signal terminals of each temperature sensor in different columns are connected in parallel via different dual-purpose signal lines. An adapter electrically connects the electrode plate and the electric field generator. The adapter has multiple grounding switches and multiple bidirectional switching switches corresponding to the electrode plate. The number of bidirectional switching switches is greater than or equal to the number of dual-purpose signal lines and / or the number of grounding switches is greater than or equal to the number of grounding wires. At least some of the grounding switches ground each grounding wire of the electrode plate one-to-one, and at least some of the bidirectional switches are electrically connected to each dual-purpose signal line of the electrode plate one-to-one. The adapter has an input terminal for receiving AC signals and a sampling terminal for receiving DC signals to collect temperature data. It is configured to transmit AC signals to the dielectric element of the corresponding electrode unit via the dual-purpose signal line electrically connected to it when AC signals are received at its input terminal, or to transmit DC signals to the signal terminal of the corresponding temperature sensor via the dual-purpose signal line electrically connected to it when DC signals are received at its sampling terminal. When at least some of the bidirectional switching switches have AC signals at their input terminals, all grounding switches are disconnected. When all the input terminals of the bidirectional switching switches are disconnected and at least some of the bidirectional switching switches have DC signals at their sampling terminals, at least some of the grounding switches are individually and sequentially turned on.

[0018] Further, the bidirectional switching switches not connected to the dual-purpose signal line are in an idle open state, and / or the grounding switches not connected to the grounding wire are in an idle open state.

[0019] Further, the adapter has four grounding switches and five bidirectional switching switches corresponding to the electrode plates.

[0020] Further, the electrode sheet is provided with a handshake chip, and the adapter is configured to send a handshake signal to the handshake chip and receive a feedback signal from the handshake chip to determine whether it is normally connected to the electrode sheet. After it is normally connected to the electrode sheet, the adapter is configured to allow the electrode sheet to enter an AC signal for tumor treatment or to enter a DC signal for temperature acquisition by configuring the states of each grounding switch and each bidirectional switching switch.

[0021] The above description is only an overview of the technical solution of this application. In order to better understand the technical means of this application and to implement it according to the contents of the specification, and to make the above and other objects, features and advantages of this application more obvious and understandable, specific embodiments of this application are given below. Brief Description of the Drawings

[0022] Figure 1 is a schematic diagram of a tumor electric field therapy system according to an embodiment of this application, which shows a spatial structure schematic diagram of the electrode sheet of the first embodiment;

[0023] Figure 2 is a schematic diagram of the structural layout of a modified embodiment of the electrode sheet used in the tumor electric field therapy system shown in Figure 1 of this application;

[0024] Figure 3 is a schematic diagram of the circuit connection of the tumor electric field system shown in Figure 1 of this application, showing the circuit connection between the electrode sheet of the first embodiment shown in Figure 1 or the electrode sheet of the modified embodiment shown in Figure 2 and the adapter shown in the first embodiment shown in Figure 1;

[0025] Figure 4 is a schematic block diagram of the internal structure of the adapter shown in Figure 3 of this application;

[0026] Figure 5 is a schematic block diagram of the internal structure of the electric field generator of the tumor electric field therapy system shown in Figure 1 of this application;

[0027] Figure 6 is similar to Figure 3, and is a schematic diagram of the circuit connection of the tumor electric field therapy system of the second embodiment of this application, showing the circuit connection between the electrode sheet used in the second embodiment of the tumor electric field therapy system of this application and the adapter shown in Figure 3; Specification 3 / 34 pages 6 CN 120983810 A

[0028] Figure 7, similar to Figure 3, is a circuit connection diagram of the tumor electric field therapy system according to the third embodiment of this application, showing the circuit connection diagram between the electrode sheet of the third embodiment of the tumor electric field therapy system and the adapter shown in Figure 3;

[0029] Figure 8, similar to Figure 3, is a circuit connection diagram of the tumor electric field therapy system according to the fourth embodiment of this application, showing the circuit connection diagram between the electrode sheet of the fourth embodiment of the tumor electric field therapy system and the adapter shown in Figure 3;

[0030] Figure 9, similar to Figure 3, is a circuit connection diagram of the tumor electric field therapy system according to the fifth embodiment of this application, showing the circuit connection diagram between the electrode sheet of the fifth embodiment of the tumor electric field therapy system and the adapter shown in Figure 3;

[0031] Figure 10 is a flowchart of a temperature detection method for the tumor electric field therapy system according to this application;

[0032] Figure 11 is a flowchart of the tumor electric field therapy system according to this application;

[0033] Figure 12 is another flowchart of a temperature detection method for the tumor electric field therapy system according to this application;

[0034] Figure 13 is a flowchart of a method for applying AC signal control for tumor electric field therapy according to this application;

[0035] Figure 14 is a flowchart illustrating the signal control method for tumor electric field therapy according to this application;

[0036] Figure 15 is a flowchart illustrating the electrode temperature detection method according to this application;

[0037] Figure 16 is a flowchart illustrating the AC signal application method for tumor electric field therapy according to this application.

[0038] Explanation of reference numerals:

[0039] Tumor electric field therapy system 100, electrode sheets 10, 10', 10D, 10E, 10F, 10H, flexible circuit boards 11, 11D,11E, 11F, 11H, Connecting parts 111, 111', Wiring parts 112, 112', Bridging parts 113, 113', Main trunk 114, 114', Branch 115, 115', First interval D1, D1', Second interval D2, D2', Electrode unit 12, 12', First cable 13, 13', Temperature sensor 14, Grounding terminal 14-1, Signal terminal 14-2, Dielectric element 15, Diode 16, Handshake chip 17, Grounding trace 171, Communication line 172, Grounding wire 18, First grounding wire 18-1, Second grounding wire 18-2, Third grounding wire 18-3, Fourth grounding wire 18-4, Dual-purpose signal line 19, First dual-purpose signal line 19-1, Second dual-purpose signal line 19-2, Third dual-purpose signal line 19-3, Fourth dual-purpose signal line 19-4, Fifth dual-purpose signal line Line 19-5, Adapter 20, Second Cable 21, First Controller 22, Analog-to-Digital Converter 23, Voltage Divider Resistor 24, Grounding Switch 25, First Grounding Switch 25-1, Second Grounding Switch 25-2, Third Grounding Switch 25-3, Fourth Grounding Switch 25-4, Bidirectional Switch 26, First Bidirectional Switch 26-1, Second Bidirectional Switch 26-2, Third Bidirectional Switch 26-3, Fourth Bidirectional Switch 26-4, Fifth Bidirectional Switch 26-5, First Communication Unit 27, AC Signal Line 28, First Power Module 29, Communication Transmission Line 211, Electric Field Generator 30, Second Power Module 31, Second Controller 32, Second Communication Unit 33, AC Signal Generator 34, AC Signal Switch 35, First AC Signal Switch 35-1, First AC Signal Switch 35- 2. First AC signal switch 35-3, first AC signal switch 35-4, first connectors 40, 40D, 40E, 40F, 40H, first plugs 41, 41', first socket 42, second connector 50, second plug 51, second socket 52. Detailed Description

[0040] The embodiments of the technical solution of this application will be described in detail below with reference to the accompanying drawings. The following embodiments are only used to more clearly illustrate the technical solution of this application, and are therefore only examples, and cannot be used to limit the scope of protection of this application.

[0041] FIG1 is a schematic diagram of a tumor electric field therapy system 100 according to an embodiment of this application. As shown in FIG1, the tumor electric field therapy system 100 includes: at least one pair of electrode plates 10, an adapter 20 connected to the electrode plates 10, and an electric field generator 30 connected to the adapter 20. An electric field generator 30 generates an alternating current signal for tumor treatment and applies it to the electrode pads 10 via an adapter 20, thereby generating a therapeutic electric field between the paired electrode pads 10. The adapter 20 is electrically connected to the electrode pads.Between electrode 10 and electric field generator 30, an alternating current signal generated by electric field generator 30 is transmitted to electrode 10. That is, electric field generator 30 can generate an alternating current signal, which is transmitted to each electrode 10 through adapter 20, creating a therapeutic electric field for tumor treatment between the same pair of electrode 10s. As shown in Figure 1, in this embodiment, there are four electrode 10s. From a spatial arrangement perspective, each electrode 10 includes multiple electrode units 12 arranged in both axially and centrally symmetrical configurations, several connecting portions 111 located between adjacent electrode units 12, a bridging portion 113 spanning between adjacent connecting portions 111, a wiring portion 112 connected to the bridging portion 113, and a first cable 13 connected to the wiring portion 112. The bridging portion 113 and the wiring portion 112 are arranged perpendicularly, forming a "T" shape. The bridging portion 113 is spanned between adjacent connecting portions 111. Each electrode unit 12 of the electrode pad 10 is electrically connected to the adapter 20 via a first cable 13 having 10 core wires.

[0042] Each electrode unit 12 has a temperature sensor 14 and a dielectric element 15. The temperature sensor 14 is used to detect the temperature of the part of the electrode unit 12 applied to the patient's body surface. It can be a thermistor element or a temperature sensor other than a thermistor, and can be set at any position on the electrode unit 12. The dielectric element 15 is used to apply an alternating current signal to the tumor site of the patient. The dielectric element 15 can be a dielectric ceramic sheet or a polymer dielectric layer made of polymer material. In this embodiment, each dielectric element 15 has a through hole (not labeled) in the middle for accommodating a corresponding temperature sensor 14. Each electrode unit 12 may also include a diode 16 connected in series with the temperature sensor 14 to prevent reverse current flow, so as to prevent the detection signal from other electrode units 12 from affecting the temperature sensor 14. The grounding terminal 14-1 of the temperature sensor 14 is connected in series with the anode of the diode 16 and grounded through the cathode of the diode 16.

[0043] In the first mode, the electrode unit 12 applies an alternating current signal through the dielectric element 15; in the second mode, the temperature of the patient's body surface to which the corresponding electrode unit 12 is applied is detected or acquired through the temperature sensor 14; in the third mode, the application of the alternating current signal is stopped and temperature detection and acquisition are stopped. The first mode, the second mode, and the third mode do not overlap in time period. That is, the time period during which the dielectric element 15 of the electrode unit 12 applies an alternating current signal is staggered and does not overlap with the time period during which the temperature sensor 14 detects the temperature. The electrode unit 12 can cycle between applying an alternating current signal through its dielectric element 15 and detecting the temperature through its temperature sensor 14, that is, the electrode unit 12 can cycle between the first mode and the second mode.The electrode unit 12 can also cycle between the first mode, the second mode, and the third mode, that is, the electrode unit 12 cycles between applying an AC signal through the dielectric element 15, collecting or detecting temperature through the temperature sensor 14, stopping the application of the AC signal, and collecting temperature.

[0044] Each electrode sheet 10 includes an electrode array (unlabeled) consisting of 20 electrode units 12. The electrode array (unlabelled) also includes a flexible circuit board 11 comprising a connection portion 111, a wiring portion 112, and a bridging portion 113. Twenty electrode units 12 are spaced apart in the electrode array (unlabelled) arranged in four rows and six columns. Specifically, the first and last rows each have four electrode units 12, and the middle two rows each have six electrode units 12. The four electrode units 12 in the first row are located in the second to fifth columns, the six electrode units 12 in each of the middle two rows are located in the first to sixth columns, and the four electrode units 12 in the last row are also located in the second to fifth columns. The connection portion 111 is located only between adjacent electrode units 12 arranged in the column direction in the third and fourth columns, and between adjacent electrode units 12 in the row direction, except for the two electrode units 12 located in the third and fourth columns of each row. That is, the two adjacent electrode units 12 in the third and fourth columns are connected only in the column direction by the connecting part 111, and are disconnected in the row direction without being connected by the connecting part 111; the electrode units 12 in the first, second, fifth and sixth columns are connected only by the horizontally arranged connecting part 111 and the electrode unit 12 adjacent to them in the row direction, and are disconnected in the column direction and between them and the adjacent electrode units 12. In other words, the two adjacent electrode units 12 in the column direction in the first, second, fifth and sixth columns are disconnected.

[0045] The electrode unit 12 in the third column and the connecting part 111 between the electrode units 12 in that column and arranged vertically, and the electrode unit 12 in the fourth column and the connecting part 111 between the electrode units 12 in that column and also arranged vertically, all constitute the backbone 114 of the electrode array (unlabeled). The connecting portions 111 located on opposite sides of the electrode units 12 in the third and fourth columns, and connected to the electrode units 12 in the third and fourth columns respectively via laterally arranged connecting portions 111, constitute branches 115 of the electrode array (unlabeled). That is, in this embodiment, the electrode array (unlabeled) includes two main trunks 114 and several branches 115 extending laterally from the two main trunks 114. Each branch 115 has a free end away from the main trunk 114, and the free ends of adjacent branches 115 are perpendicular to each other.The branches are arranged in a disconnected manner, and the positions and distances between adjacent branches 115 can be freely adjusted according to actual usage needs. Specifically, one main branch 114 is composed of each electrode unit 12 located in the third column and a connecting portion 111 arranged longitudinally between adjacent electrode units 12 in that column. The other main branch 114 is composed of each electrode unit 12 located in the fourth column and a connecting portion 111 arranged longitudinally between adjacent electrode units 12 in that column. The remaining electrode units 12 connected to the main branch 114 by the transversely arranged connecting portions 111 are all branches 115.

[0046] Specifically, the branches 115 are: a connecting portion 111 extending laterally to the left from the electrode unit 12 in the first row of the third column and located in the first row, and an electrode unit 12 connected to the connecting portion 111 and located in the second column of the first row; two connecting portions 111 extending laterally to the left from the electrode unit 12 in the second row of the third column and located in the second row, and two electrode units 12 located in the first column and second column of the second row; two connecting portions 111 extending laterally to the left from the electrode unit 12 in the third row and located in the third row, and two electrode units 12 located in the first column and second column of the third row; a connecting portion 111 extending laterally to the left from the electrode unit 12 in the fourth row and located in the fourth row, and two electrode units 12 located in the first column and second column of the third row; Electrode unit 12 in the second column of the fourth row; a connecting portion 111 extending laterally to the right from the electrode unit 12 in the first row of the fourth row and located in the first row and an electrode unit 12 in the fifth column of the first row; two connecting portions 111 extending laterally to the right from the electrode unit 12 in the second row of the fourth row and located in the second row and two electrode units 12 located in the fifth and sixth columns of the second row; two connecting portions 111 extending laterally to the right from the electrode unit 12 in the third row of the fourth row and located in the third row and two electrode units 12 located in the fifth and sixth columns of the third row; a connecting portion 111 extending laterally to the right from the electrode unit 12 in the fourth row of the fourth row and located in the fourth row and an electrode unit 12 located in the fifth column of the fourth row.

[0047] The electrode array (unlabelled) is divided into a symmetrical left portion including three columns on the left and a right portion including three columns on the right, and the left portion and the right portion are connected only by a bridging portion 113. The left side consists of a main stem 114 located in the third column and several branches 115 extending to the left from the main stem 114. The right side consists of a main stem 114 located in the fourth column and several branches 115 extending to the right from the main stem 115. The two main stems 114 are connected by a bridging portion 113. Specifically, the two main stems 114 are connected by a connecting portion 111 that connects the electrode unit 12 in the second row of the third column with the electrode unit 12 in the third row of the third column, and a connecting portion 111 that connects the electrode unit 12 in the second row of the fourth column with the electrode unit 12 in the third row of the fourth column.The bridging portion 113 between the connecting portions 111 of the units 12 is electrically connected. The connecting portions 111 connecting the electrode units 12 in the second row of the third column with the electrode units 12 in the third row of the third column, the connecting portions 111 connecting the electrode units 12 in the second row of the fourth column with the electrode units 12 in the third row of the fourth column, and the bridging portion 113 are generally arranged in an "H" shape. In other embodiments, the bridging portion 113 may also be provided between an electrode unit 112 located in the third column and an electrode unit 12 located in the fourth column. Optionally, the bridging portion 113 is provided between two electrode units 12 located in the third and fourth columns and adjacent in the row direction.

[0048] Each electrode unit 12, according to its position in the electrode array (unnumbered), can be divided into peripheral electrode units 12 and central electrode units 12. The peripheral electrode units 12 include four electrode units 12 in the first row, two electrode units 12 at opposite ends in the second row, two electrode units 12 at opposite ends in the third row, and four electrode units 12 in the fourth row. The central electrode units 12 include four electrode units 12 in the middle of the second row and four electrode units 12 in the middle of the third row. Among the multiple peripheral electrode units 12, some adjacent electrode units 12 are connected by a horizontally arranged connecting part 111, while some adjacent electrode units 12 are disconnected. Among the multiple peripheral electrode units 12, the adjacent electrode units 12 connected by the connecting part 111 are some row-adjacent electrode units 12. Specifically, among the multiple electrode units 12 located on the periphery, two electrode units 12 that are adjacent in a column direction or diagonally adjacent are disconnected; some two electrode units 12 that are adjacent in a row direction are also disconnected; only some two electrode units 12 that are adjacent in a row direction are connected by a laterally extending connecting portion 111. Among the multiple electrode units 12 located in the center, only two electrode units 12 that are adjacent in a column direction on the main trunk 114 are connected by a longitudinally arranged connecting portion 111, and only two electrode units 12 that are adjacent in a row direction on the branch 115 are connected by a laterally arranged connecting portion 111.

[0049] The electrode array (unlabeled) also has intervals (unlabeled) formed between a number of spaced electrode units 12, which allows moisture from the patient's skin to escape, allows heat exchange between the patient's skin and the outside world, or allows the patient's skin to breathe freely, and also allows the positions and spacing between the branches 115 to be freely adjusted, and also avoids wrinkles when the electrode pads 10 are applied. The intervals (unnumbered) include a first interval D1 located between the two main branches 114 and a second interval D2 located between each branch 115. The first interval D1 is located between the third column electrode unit 12 and the fourth column electrode unit 12, while the second interval D2 is located between electrode units 12 in adjacent rows. That is, moving upwards along the rows, the electrode unit 12 in the third column and the adjacent electrode unit 12 in the fourth column...The electrodes are disconnected, and no connecting part 111 is provided, but the aforementioned first interval D1 is formed; and along the column upwards, only the two adjacent electrode units 12 in the third and fourth columns are connected by the connecting part 111, while the two adjacent electrode units 12 in the other four columns are not connected by the connecting part 111, but form the aforementioned second interval D2. The setting of the first and second intervals D1 and D2 can also increase the degree of freedom of some electrode units 12, and can also avoid wrinkles when attaching the electrode sheet 10.

[0050] The electrode sheet 10 also includes a handshake chip 17 disposed on the flexible circuit board 11 and used to confirm its connection status. The handshake chip 17 can communicate with the electric field generator 30 through the adapter 20 to determine the connection status between the electrode sheet 10 and the adapter 20. The electric field generator 30 of the tumor electric field therapy system 100 first sends a handshake communication signal to the handshake chip 17 of the electrode sheet 10 through the adapter 20, and determines the connection status of the electrode sheet 10 based on whether it receives feedback from the handshake chip 17. The electric field generator 30 of the tumor electric field therapy system 100, after confirming the normal connection of the electrode pads 10 via the handshake chip 17, applies an AC signal to the dielectric element 15 of the electrode pads 10 or transmits a DC signal to each temperature sensor 14 of the electrode pads 10 to acquire temperature detection signals. The handshake chip 17 can be an EEPROM with encryption function.

[0051] In some other embodiments, the tumor electric field therapy system 100 may have more or fewer electrode pads 10. In some other embodiments, each pair of electrode pads 10 has the same or different number of electrode units 12, and different pairs of electrode pads 10 may also have different numbers of electrode units 12. In some other embodiments, 20 electrode units 12 may also be arranged in other ways. Of course, in some other embodiments, the electrode pads 10 may also have other numbers of electrode units 12. In some other embodiments, 20 electrode units 12 may also be arranged in other ways, as shown in electrode pad 10' in FIG2. Of course, in some other embodiments, the electrode pads 10 may also have other numbers of electrode units 12. In summary, the implementation of this application is not limited by the number and arrangement of the electrode units 12 of the electrode sheet 10.

[0052] The electrode sheet 10' shown in FIG2 is a modified embodiment of the electrode sheet 10 shown in FIG1. ​​The spatial structure of the electrode sheet 10' is the same as that of the electrode sheet 10, and it also includes a plurality of electrode units 12' arranged at intervals, a plurality of connecting portions 111' located between two adjacent electrode units 12', a wiring portion 112' connected to the bridging portion 113', and a first cable 13' connected to the wiring portion 112', a first interval D1 formed between the third column of electrode units 12' and the fourth column of electrode units 12', and a second interval D2' formed between adjacent rows of electrode units 12'; the connecting portion 111', the wiring portion 112', and the bridging portion 113' also constitute the specification.Page 7 / 34, 10 CN 120983810 A Flexible Circuit Board (unnumbered), the electrode sheet 10' is also connected to the adapter 20 through the first plug 41' of the first cable 13' with 10 core wires. The only difference is that: the two adjacent electrode units 12' in the fourth column are disconnected and not connected by the longitudinally arranged connecting part 111', but the two adjacent electrode units 12' in the fifth column are connected by the longitudinally arranged connecting part 111'. Each electrode unit 12' in the fourth column is connected to the electrode unit 12' in the fifth column and adjacent in the row direction through the transversely arranged connecting part 111'; and the bridging part 113' is connected between the two electrode units 12' located in the third row and third column and the two electrode units 12' located in the third row and fourth column. One main trunk 114' is composed of an electrode unit 12' located in the third column and a connecting portion 111' located between the electrode units 12' in that column, and the other main trunk 114' is composed of an electrode unit 12' located in the fifth column and a connecting portion 111' located between the electrode units 12' in that column. The structure of the left side of the left three columns of the electrode array (unlabeled) is exactly the same as the structure of the left side of the electrode array (unlabeled) shown in FIG1. ​​Only the right side is different because the position of the main trunk 114' changes from the fourth column to the fifth column, resulting in the branches 115' in the right side extending to the left and right sides of the corresponding electrode unit 12' in the main trunk 114' respectively.

[0053] FIG3 is a schematic diagram of the circuit connection between the electrode sheet 10 of the first embodiment of the tumor electric field therapy system 100 shown in FIG1 or the electrode sheet 10' of the transformation embodiment shown in FIG2 and the adapter 20 of the first embodiment. It is worth noting that the arrangement of electrode units 12 shown in Figure 3 is to more clearly illustrate the electrical connection between an electrode sheet 10 and the adapter 20. The arrangement of electrode units 12 shown in Figure 3 does not represent the spatial arrangement of electrode units 12. The circuit connection is described below using the electrode sheet 10 in the first embodiment as an example.

[0054] Referring to Figures 1 and 3, in this embodiment, each electrode sheet 10 is provided with 20 electrode units 12. The 20 electrode units 12 are arranged in the order of 1 to 20 in the circuit connection and are divided into four row groups and five column groups, that is, the 20 electrode units 12 are arranged in four rows and five columns in the circuit connection. The temperature sensor 14 of each electrode unit 12 includes a ground terminal 14-1 and a signal terminal 14-2. The dielectric element 15 and the temperature sensor 14 of each electrode unit 12 are soldered on the flexible circuit board 11, and the dielectric element 15 is short-circuited to the signal terminal 14-2 of the corresponding temperature sensor 14. Since the electrode units 12 are arranged in four rows and five columns in the circuit connection, and each electrode unit includes a corresponding dielectric element 15 and a corresponding temperature sensor 14, the multiple temperature sensors 14 are also arranged in four rows and five columns in the circuit connection, and the multiple dielectric elements 15 are also arranged in the circuit connection.The connection is also arranged in four rows and five columns. It should be noted that the arrangement here is to more clearly show the electrical connection between the electrode plate 10 and the adapter 20, and does not represent the spatial arrangement of the electrode unit 12. Its spatial structure may be a roughly array structure as shown in Figure 1, or it may be other structures, such as petal-shaped or scattering, and it may be a regular or irregular structure. The dielectric element 15 is configured to apply an alternating electric field to the tumor site of the patient. The temperature sensor 14 is configured to detect the temperature of the patient's body surface that is in contact with the electrode plate 10 and output a temperature detection signal to the adapter 20.

[0055] The flexible circuit board 11 is embedded with multiple conductive traces 171, 172, 18, and 19. The multiple conductive traces 171, 172, 18, and 19 include multiple ground lines 18, multiple dual-purpose signal lines 19, one ground trace 171, and one communication line 172. One end of the grounding trace 171 is connected to the grounding pin of the handshake chip 17, and the other end is connected to any grounding line 18. The grounding pin of the handshake chip 17 is connected to the grounding trace 171, and its communication pin is electrically connected to the communication line 172. That is, the handshake chip 17 is grounded through the grounding line 18 connected to the grounding trace 171, and communicates with external devices through the communication line 172. Specifically, the handshake chip 17 is grounded through the grounding trace 171 connected to its grounding pin and a grounding line 18, and is connected to the communication line 172 of the flexible circuit board 11, a wire electrically connected to the communication line 172 of the first cable 13, an adapter 20 electrically connected to the first cable 13, and an electric field generator 30 electrically connected to the adapter 20 to achieve communication connection between itself and the electric field generator 30, thereby determining the connection status of the electrode sheet 10. The first cable 13 has multi-core wires (not shown) that are electrically connected to the communication line 172, the multi-grounding line 18, and the multi-purpose signal line 19 of the flexible circuit board 11 respectively. The total number of communication lines 172, grounding lines 18, and dual-purpose signal lines 19 embedded in the flexible circuit board 11 does not exceed 10. Therefore, the number of wires in the first cable 13 does not exceed 11.

[0056] The number of conductive lines electrically connected to the grounding lines 18 in the tumor electric field therapy system 100 is related to the number of rows M of the electrode unit 12, which can be greater than or equal to the number of rows of the electrode unit 12, where M is a positive integer. The number of conductive lines electrically connected to the dual-purpose signal lines 19 in the tumor electric field therapy system 100 is related to the number of columns N of the electrode unit 12, which can be greater than or equal to the number of columns of the electrode unit 12, where N is a positive integer. In this embodiment, the number of grounding lines 18 is equal to the number of rows M of the electrode unit 12; the number of dual-purpose signal lines 19 is equal to the number of columns N of the electrode unit 12. The number of lines L embedded in the flexible circuit board 11, etc.The sum of the number of grounding wires 18 and the number of dual-purpose signal lines 19 plus 2, i.e., L=M+N+2. The number of conductors in the first cable 13 is M+N+1.

[0057] The multiple dual-purpose signal lines 19 of the flexible circuit board 11 are respectively arranged in a one-to-one correspondence with multiple columns of the electrode unit 12. They are configured to transmit the AC signal generated by the electric field generator 30 to the dielectric element 15 in each electrode unit 12 in the corresponding column. That is, the dielectric elements 15 located in the same column are all short-circuited through the same dual-purpose signal line 19 of the flexible circuit board 11, and the dielectric elements 15 located in different columns are respectively connected in parallel through different dual-purpose signal lines 19 of the flexible circuit board 11. The dual-purpose signal lines 19 of the flexible circuit board 11 are respectively electrically connected to the corresponding conductors in the first cable 13, and then electrically connected to the electric field generator 30 through the adapter 20. That is, the dual-purpose signal line 19 of the flexible circuit board 11 receives the AC signal generated by the electric field generator 30 through the first cable 13 and the adapter 20.

[0058] The multiple grounding lines 18 are respectively set to correspond one-to-one with the multiple rows of the electrode unit 12. The multiple grounding lines 18 are used to short-circuit and ground the temperature sensor 14 of each electrode unit 12 in each row group in sequence. That is, the grounding terminals 14-1 of the multiple temperature sensors 14 located in the same row group are all short-circuited through the same grounding line 18 of the flexible circuit board 11, and the grounding terminals 14-1 of the temperature sensors 14 located in different row groups are respectively connected in parallel through different grounding lines 18 of the flexible circuit board 11. During the time period of temperature detection or in the second mode, only one of the multiple grounding lines 18 is conducting at the same time, and the rest are disconnected.

[0059] Each of the multiple dual-purpose signal lines 19 is also configured to transmit the DC signal to the temperature sensor 14 in each electrode unit 12 in the corresponding column group to collect and transmit the detected temperature signal. Multiple temperature sensors 14 located in different column groups have their respective signal terminals 14-2 connected in parallel via different dual-purpose signal lines 19 on the flexible circuit board 11. Multiple temperature sensors 14 located in the same column group have their respective signal terminals 14-2 shorted to the same dual-purpose signal line 19 on the flexible circuit board 11, with the shorting point serving as a temperature sampling point. Specifically, each dual-purpose signal line 19 is configured to short-connect the signal terminal 14-2 of at most one electrode unit 12 of the temperature sensor 14 in each row group to an external device for receiving detection signals. The signal terminals 14-2 of each temperature sensor 14 connected to each of the multiple dual-purpose signal lines 19 are different to avoid subsequent duplicate signal outputs from the dual-purpose signal lines 19. That is, when the number of electrode units 12 in a row group is the same as the number of dual-purpose signal lines 19, each dual-purpose signal line 19 is electrically connected to a different electrode unit 12 in that row group.The signal terminals 14-2 of the temperature sensor 14 of each electrode unit 12; when the number of electrode units 12 in a row group is less than the number of dual-purpose signal lines 19, at least one dual-purpose signal line 19 is not electrically connected to the signal terminals 14-2 of the temperature sensor 14 of the electrode unit 12, and the remaining dual-purpose signal lines 19 are electrically connected to the signal terminals 14-2 of the temperature sensor 14 of a different electrode unit 12 in that row group. In this embodiment, the external device for receiving the detection signal is an adapter 20. The dual-purpose signal lines 19 of the flexible circuit board 11 receive DC signals from the adapter 20 or the electric field generator 30 through the first cable 13, and transmit the collected or detected temperature signals to the adapter 20, and then to the electric field generator 30 through the adapter 20.

[0060] In this embodiment, with each electrode unit 12 equipped with a temperature sensor 14 for temperature detection, the above-mentioned circuit design reduces the number of wires in the first cable 13, avoiding the cable becoming thicker and harder, thus increasing the difficulty of cable fixation; at the same time, it avoids the increased number of wires in the first cable 13 affecting the adhesion effect between the electrode sheet 10 and the patient's tumor site.

[0061] The flexible circuit board 11 has a total of 9 lines, including the grounding wire 18 and the dual-purpose signal line 19. In this embodiment, the flexible circuit board 11 has 4 grounding wires 18 and 5 dual-purpose signal lines 19. Specifically, the electrode sheet 10 in this embodiment includes 4 grounding wires 18, each grounding wire 18 being used to ground the grounding terminals 14-1 of the temperature sensors 14 in the same row group. The four grounding wires 18 of the electrode sheet 10 are the first grounding wire 18-1, the second grounding wire 18-2, the third grounding wire 18-3, and the fourth grounding wire 18-4. In the four rows of the electrode sheet 10, the first row includes electrode units 12-1 to 12-5, the second row includes electrode units 12-6 to 12-10, the third row includes electrode units 12-11 to 12-15, and the fourth row includes electrode units 12-16 to 12-20. Specifically, the first grounding wire 18-1 is used to ground electrode units 12-1 to 12-5 in the first row group; the second grounding wire 18-2 is used to ground electrode units 12-6 to 12-10 in the second row group; the third grounding wire 18-3 is used to ground electrode units 12-11 to 12-15 in the third row group; and the fourth grounding wire 18-4 is used to ground electrode units 12-16 to 12-20 in the fourth row group. It should be noted that these grounding wires 18 can be selectively closed or opened, which can be achieved by connecting each grounding wire 18 in series with a switch, as will be described in detail below. The above-mentioned "grounding electrode units 12" can...This refers to grounding the grounding terminal 14-1 of the temperature sensor 14 in the electrode unit 12, or it can refer to the diode 16 being connected in series with the temperature sensor 14 of the same electrode unit 12 and grounded together. In short, each grounding line 18 short-circuits and grounds the grounding terminals 14-1 of the temperature sensors 14 of all electrode units 12 in the corresponding row group. The fourth grounding line 18-4 is also short-circuited with the grounding trace 171 connected to the grounding pin of the handshake chip 17.

[0062] Continuing to refer to FIG3, the electrode sheet 10 of this embodiment also includes 5 dual-purpose signal lines 19. One end of each dual-purpose signal line 19 is connected to all electrode units 12 in each column group, and the other end is connected to the adapter 20 for receiving temperature detection signals and transmitting AC signals. That is, for each row group, each dual-purpose signal line 19 can be selectively connected to one of the electrode units 12 or not connected to any of the electrode units 12 in that row group to avoid the dual-purpose signal line 19 outputting repeated signals in the future. Specifically, the five dual-purpose signal lines 19 of the electrode sheet 10 include a first dual-purpose signal line 19-1, a second dual-purpose signal line 19-2, a third dual-purpose signal line 19-3, a fourth dual-purpose signal line 19-4, and a fifth dual-purpose signal line 19-5. One end of the first dual-purpose signal line 19-1 is simultaneously connected to the dielectric element 15 of each of the four electrode units 12 (electrode unit 12-1, electrode unit 12-6, electrode unit 12-11, and electrode unit 12-16) and the signal terminal 14-2 of their respective temperature sensors 14; one end of the second dual-purpose signal line 19-2 is simultaneously connected to the electrode units 12-2, 12-7, 12-8, 12-9 ... 12. Each of the four electrode units 12 (12-17) has its own dielectric element 15 and its own temperature sensor 14 signal terminal 14-2. One end of the third dual-purpose signal line 19-3 is connected to the dielectric element 15 and its own temperature sensor 14 signal terminal 14-2 of each of the four electrode units 12 (12-3, 12-8, 12-13, 12-18). One end of the fourth dual-purpose signal line 19-4 is connected to the dielectric element 15 and its own temperature sensor 14 signal terminal 14-2 of each of the four electrode units 12 (12-4, 12-9, 12-14, 12-19). One end of the fifth dual-purpose signal line 19-5 is connected to the dielectric element 15 and its own temperature sensor 14 signal terminal 14-2 of each of the four electrode units 12 (12-5, 12-10, 12-15, 12-20). In short, each dual-purpose signal line 19 shorts in parallel the signal terminals 14-2 of each dielectric element 15 and each temperature sensor 14 located in the same column group, and is used to connect to external devices. It should be noted that these two...Signal line 19 can selectively transmit AC signals or receive temperature detection signals. This can be achieved by connecting each dual-purpose signal line 19 in series with a bidirectional switching switch 26 and coordinating with the closing or opening of grounding line 18, which will be described in detail below.

[0063] In other embodiments, the grounding line 18 and dual-purpose signal line 19 embedded in the flexible circuit board 11 may have other numbers depending on the circuit arrangement and number of electrode units 12 in different electrode sheets, as described on page 10 / 34 of the specification (CN 120983810 A). This will be specifically described in subsequent embodiments.

[0064] In this embodiment, the grounding pin of the handshake chip 17 used by the electrode sheet 10 to confirm its connection status is connected to the fourth grounding line 18-4 through the grounding trace 171 embedded in the flexible circuit board 11. The first cable 13 has 10 core wires, namely 4 grounding lines 18, 5 dual-purpose signal lines 19 and 1 communication line 172. The specific connection relationship and working principle of the handshake chip 17 will be described in detail below.

[0065] The tumor electric field therapy system 100 of this embodiment includes at least one pair of electrode pads 10 described above, an adapter 20 electrically connected to the electrode pads 10, and an electric field generator 30 electrically connected to the adapter 20. The adapter 20 is connected between the electrode pads 10 and the electric field generator 30. When the electric field generator 30 or the adapter 20 controls the grounding pin of the handshake chip 17 to be grounded, the electric field generator 30 sends a handshake communication signal to the handshake chip 17 of the electrode pads 10 via the communication line 172 of the adapter 20 and the electrode pads 10 to determine the connection status of the electrode pads 10. When the electrode plates 10 are properly connected, the electric field generator 30 provides AC signals to the dielectric elements 15 in the multiple electrode units 12 of the electrode plate 10 via the adapter 20 and the dual-purpose signal line 19 of the electrode plate 10, or provides DC signals to the temperature sensors 14 in the multiple electrode units 12 of the electrode plate 10 via the adapter 20 and the dual-purpose signal line 19 of the electrode plate 10, and is used to receive temperature detection signals output by the temperature sensors 14 in the multiple electrode units 12. The adapter 20 is configured to send a handshake communication signal to the communication line 172 of the electrode plate 10 according to the communication command of the electric field generator 30, and is configured to transmit the AC signals generated by the electric field generator 30 to the dual-purpose signal line 19 of the electrode plate 10, and is also configured to transmit DC signals to the dual-purpose signal line 19 of the electrode plate and receive temperature detection signals output by the multiple dual-purpose signal line 19 of the electrode plate 10.

[0066] Continuing to refer to Figures 3 and 4, the adapter 20 includes: a first controller 22, a multi-channel communication transmission line 211 electrically connected to the first controller 22, multiple sets of analog-to-digital converters 23 connected to the first controller 22, and multiple sets of analog-to-digital converters 23 connected to each other.The adapter 20 includes multiple sets of voltage-reducing resistors 24, multiple sets of grounding switches 25, multiple sets of bidirectional switching switches 26 corresponding to multiple sets of analog-to-digital converters 23, a first communication unit 27, AC signal lines 28 corresponding to each set of bidirectional switching switches 26, and a first power module 29 connected to the first communication unit 27, the first controller 22, and the multiple sets of analog-to-digital converters 23. The first power module 29 provides DC power VCC to each electronic component of the adapter 20. The adapter 20 also includes multiple circuit lines (unlabeled). These multiple circuit lines (unlabeled) are electrically connected to multiple grounding lines 18, multiple dual-purpose signal lines 19, and communication lines 172 in the flexible circuit board 11 of the corresponding electrode plate 10 via the first cable 13 of the corresponding electrode plate 10. The multiple circuit lines (unlabeled) include multiple AC signal lines 28 that transmit AC signals to the corresponding electrode 10 and are electrically connected to the multi-purpose signal lines 19 in the flexible circuit board 11 of the corresponding electrode 10; multiple circuit lines (unlabeled) that are electrically connected one-to-one to the multi-purpose signal lines 19 in the flexible circuit board 11 of the corresponding electrode 10 and are used to power the temperature sensors 14 of the electrode 10 or transmit the temperature detection signals of the electrode 10; multiple circuit lines (unlabeled) that are electrically connected one-to-one to the grounding lines 18 in the flexible circuit board 11 of the corresponding electrode 10; and multiple communication transmission lines 211 that are electrically connected one-to-one to the communication lines 172 in the flexible circuit board 11 of the corresponding electrode 10. All communication transmission lines 211 are connected to the first controller 22. Each communication transmission line 211 is connected to the communication line 172 of the flexible circuit board 11 through the corresponding first connector 40, and the first controller 22 and the handshake chip 17 are electrically connected to the handshake chip 17 through the grounding switch 25 corresponding to the grounding line 18 shorted by the grounding pin of the handshake chip 17 of the closed flexible circuit board 11, so that the handshake chip 17 can obtain power and enable the data communication function.

[0067] The number P of the circuit lines P that the adapter 20 is electrically connected to one electrode piece 10 is equal to the sum of the number of rows M and the number of columns N of the electrode unit 12 of the electrode piece 10 plus 2; the number H of the circuits that the adapter 20 is electrically connected to X electrode pieces 10 is equal to X times the number of circuit lines that it is electrically connected to a single electrode piece 10, that is. The number of groups of grounding switches 25, the number of groups of bidirectional switching switches 26, the number of AC lines 28, and the number of communication transmission lines 211 are all related to the number of electrode pieces 10. The number of grounding switches 25, the number of bidirectional switching switches 26, the number of AC lines 28, and the number of communication transmission lines 211 are all the same; and not less than the number of electrode plates 10. Preferably, the number of grounding switches 25, the number of bidirectional switching switches 26, the number of AC lines 28, and the number of communication transmission lines 211 are all the same.The number of wires 211 is the same as the number of electrode plates 10. The following detailed description only uses the electrical connection between an electrode plate 10 with 20 electrode units 12 and the adapter 20 as an example.

[0068] Each group of grounding switches 25 is provided with multiple grounding switches 25. These multiple grounding switches 25 are respectively connected to the adapter 20 and electrically connected to the circuit lines (unlabeled) corresponding one-to-one with the multiple grounding wires 18 of a corresponding electrode plate 10, and are configured to control the conduction or disconnection of the multiple grounding wires 18. The circuit lines (unlabeled) that are electrically connected one-to-one with the multiple grounding wires 18 of the electrode plate 10 are grounded at the end closest to the grounding switch 25. The number of grounding switches 25 in each group of grounding switches 25 is related to the number of grounding wires 18 of the corresponding flexible circuit board 11 of the electrode plate 10; in this embodiment, the two are equal. As shown in Figure 3, in this embodiment, each group of grounding switches 25 includes a first grounding switch 25-1, a second grounding switch 25-2, a third grounding switch 25-3, and a fourth grounding switch 25-4. Each group of multiple grounding switches 25 controls the closing or opening of the corresponding grounding wire 18 of a corresponding electrode piece 10. Specifically, the first grounding switch 25-1 controls the closing or opening of the first grounding wire 18-1 of the corresponding electrode piece 10, and can then cooperate with the corresponding group of bidirectional switching switches 26 to control the energization and de-energization of the temperature sensors 14 of the five electrode units 12 (electrode units 12-1 to 12-5) in the first row of the electrode piece 10. The second grounding switch 25-2 is used to control the opening or closing of the second grounding wire 18-2 of the electrode plate 10, and can then cooperate with the corresponding set of bidirectional switching switches 26 to control the energization and de-energization of the temperature sensors 14 of the five electrode units 12 from electrode unit 12-6 to electrode unit 12-10 in the second row of the electrode plate 10; the third grounding switch 25-3 is used to control the opening or closing of the third grounding wire 18-3 of the electrode plate 10, and can then cooperate with the corresponding set of bidirectional switching switches 26 to control the energization and de-energization of the temperature sensors 14 of the five electrode units 12 from electrode unit 12-6 to electrode unit 12-10 in the third row of the electrode plate 10. The temperature sensors 14 of each of the five electrode units 12 in units 12-15 are energized and de-energized; the fourth grounding switch 25-4 is used to control the closing or opening of the fourth grounding wire 18-4 of the electrode plate 10, and then determines the connection status of the electrode plate 10 by the electrical connection status between the communication line 172 of the handshake chip 17 and the communication transmission line 211 of the adapter 20, and can also cooperate with the corresponding group of bidirectional switching switches 26 to control the energization and de-energization of the temperature sensors 14 of each of the five electrode units 12 in the fourth row group of the electrode plate 10 from electrode units 12-16 to electrode units 12-20. The grounding switch 25 can be a mechanical switch, such as a relay. The grounding switch 25 can also be an electronic switch, and each grounding switch 25 can be opened and closed by the first controller 22 of the adapter 20.

[0069] In this embodiment, all sets of grounding switches 25 are electronic switches. The first controller 22 is communicatively connected to the multiple sets of grounding switches 25 and is used to sequentially and cyclically control the opening and closing states of multiple grounding switches 25 in each set of grounding switches 25, thereby sequentially and individually turning on each of the multiple grounding wires 18 of the corresponding electrode 10 and cooperating with the switching of the corresponding bidirectional switching switch 26, so as to sequentially and time-divisionally collect the temperature of the patient's body surface detected by all temperature sensors 14 on the electrode 10. The number of grounding switches 25 in each set is greater than or equal to the number of grounding wires 18 of the flexible circuit board 11 of the corresponding electrode 10. In this embodiment, the number of grounding switches 25 in each set is the same as the number of grounding wires 18 of the corresponding electrode 10.

[0070] Each set of bidirectional switching switches 26 is provided with multiple bidirectional switching switches 26, and the multiple bidirectional switching switches 26 in each set are respectively connected to the adapter 20 and electrically connected to the circuit lines (unlabeled) corresponding one-to-one with the multi-channel dual-purpose signal lines 19 of the corresponding electrode 10. The number of bidirectional switching switches 26 in each group is related to the number of dual-purpose signal lines 19 on the flexible circuit board 11 of the corresponding electrode sheet 10, and is greater than or equal to the number of dual-purpose signal lines 19 on the flexible circuit board 11 of the corresponding electrode sheet 10. In the embodiment shown in FIG3, the two are equal. Each bidirectional switching switch 26 has a sampling terminal 1 and an input terminal 2. The sampling terminals 1 of multiple bidirectional switching switches 26 in the same group are electrically connected to the corresponding detection channels in the multiple detection channels of the corresponding group of analog-to-digital converters 23. Each detection channel corresponds one-to-one with the temperature sampling point of the corresponding specification page 12 / 34 15 CN 120983810 A. The input terminal 2 of each bidirectional switching switch 26 in the same group is electrically connected to the corresponding AC signal line 28. Each bidirectional switching switch 26 is configured to control the multiple dual-purpose signal lines 19 to connect to the corresponding AC signal line 28 to transmit AC signals or to connect to the corresponding detection channel of the corresponding group of analog-to-digital converters 23 to receive the temperature detection signal output by the temperature sensor 14.

[0071] As shown in FIG3, taking the electrical connection of an electrode plate 10 with the adapter 20 as an example, in this embodiment with 20 electrode units 12, the multiple bidirectional switching switches 26 are respectively a first bidirectional switching switch 26-1, a second bidirectional switching switch 26-2, a third bidirectional switching switch 26-3, a fourth bidirectional switching switch 26-4, and a fifth bidirectional switching switch 26-5. The multiple bidirectional switching switches 26 in the same group each control the switching of a corresponding dual-purpose signal line 19 of the same electrode plate 10 between transmitting AC power signals and transmitting temperature detection signals.

[0072] Specifically, the first bidirectional switching switch 26-1 is used to control the first dual-purpose signal line 19-1 of the corresponding electrode plate 10 between transmitting AC power signals and transmitting temperature detection signals.The switching between transmitting AC signals and transmitting temperature detection signals controls the conduction of each dielectric element 15 in the first column of electrode units 12-1, 12-6, 12-11, and 12-16 of the electrode sheet 10, and the conduction of each temperature sensor 14 in the first column of electrode units 12-1, 12-6, 12-11, and 12-16 of the electrode sheet 10. The switching between the conduction of signal terminal 14-2 and the corresponding grounding switches 25-1, 25-2, 25-3, and 25-4 is coordinated to enable the first column of electrode units 12-1, 12-6, 12-11, and 12-16 to transmit AC signals to the patient or output temperature detection signals collected by the temperature sensors 14 of the electrode units 12 to the corresponding analog-to-digital converter 23; the second bidirectional switching switch 26-2 is used to control the switching between transmitting AC signals and transmitting temperature detection signals of the second dual-purpose signal line 19-2 of the corresponding electrode pad 10, thereby controlling the conduction of each dielectric element 15 of the electrode units 12-2, 12-7, 12-12, and 12-17 in the second column of the electrode pad 10 and the conduction of the electrode units 12-2, 12-7, 12-12, and 12-17 in the second column of the electrode pad 10. The switching between the conduction of the signal terminals 14-2 of each temperature sensor 14 and the corresponding grounding switches 25-1, 25-2, 25-3, and 25-4 is coordinated to enable the second row of electrode units 12-2, 12-7, 12-12, and 12-17 to transmit AC signals to the patient or output temperature detection signals collected by the temperature sensors 14 of these electrode units 12 to the corresponding analog-to-digital converter 23; the third bidirectional switching switch 26-3 is used to control the switching between transmitting AC signals and transmitting temperature detection signals on the third dual-purpose signal line 19-3 of the corresponding electrode pad 10. This controls the switching between the conduction of the dielectric elements 15 of electrode units 12-3, 12-8, 12-13, and 12-18 in the third column of the electrode pad 10 and the conduction of the signal terminals 14-2 of the temperature sensors 14 of the electrode units 12-3, 12-8, 12-13, and 12-18, and coordinates with the corresponding first grounding switch 25-1, second grounding switch 25-2, third grounding switch 25-3, and fourth grounding switch 25-4, so that the third column of electrode units 12-3, 12-8, 12-13, and 12-18 transmits AC signals to the patient or outputs temperature detection signals collected by the temperature sensors 14 of these electrode units 12 to the corresponding analog-to-digital converter 23;The four bidirectional switching switches 26-4 are used to control the switching of the fourth dual-purpose signal line 19-4 of the corresponding electrode plate 10 between transmitting AC signals and transmitting temperature detection signals. This controls the switching between the conduction of the dielectric elements 15 of each electrode unit 12-4, 12-9, 12-14, and 12-19 in the fourth column of the electrode plate 10 and the conduction of the signal terminals 14-2 of each temperature sensor 14 in the fourth column of the electrode unit 12-4, 12-9, 12-14, and 12-19, and the switching of these two functions. This is also coordinated with the corresponding first grounding switch 25-1, second grounding switch 25-2, and third grounding switch 25-3. The fourth grounding switch 25-4 is used to enable the fourth row of electrode units 12-4, 12-9, 12-14, and 12-19 to transmit AC signals to the patient or output temperature detection signals collected by the temperature sensors 14 of these electrode units 12 to the corresponding analog-to-digital converter 23; the fifth bidirectional switch 26-5 is used to control the fifth dual-purpose signal line of the corresponding electrode pads 10. (Instruction manual page 13 / 34, 16 CN 120983810 A) 19-5 switches between transmitting AC signals and transmitting temperature detection signals, thereby controlling the switching between the conduction of the dielectric elements 15 of the electrode units 12-5, 12-10, 12-15, and 12-20 in the fifth column of the electrode pad 10 and the conduction of the signal terminals 14-2 of the temperature sensors 14 of the electrode units 12-5, 12-10, 12-15, and 12-20 in the fifth column. This switching is coordinated with the corresponding first grounding switch 25-1, second grounding switch 25-2, third grounding switch 25-3, and fourth grounding switch 25-4, so that the fifth column of electrode units 12-5, 12-10, 12-15, and 12-20 transmits AC signals to the patient or outputs the temperature detection signals collected by the temperature sensors 14 of these electrode units 12 to the corresponding analog-to-digital converter 23.

[0073] When all grounding switches 25 are open and the input terminal 2 of each bidirectional switching switch 26 is on while the sampling terminal 1 is off, AC signals can be transmitted to the dielectric elements 15 of each electrode unit 12 of the corresponding electrode plate 10. When the sampling terminal 1 of each bidirectional switching switch 26 is on while the input terminal 2 is off, it can cooperate with each grounding switch 25 in the corresponding group of grounding switches 25 to transmit the temperature detection signals collected by the temperature sensors 14 of each electrode unit 12 on the electrode plate 10 in a time-division manner. The bidirectional switching switch 26 can be a mechanical switch, such as a relay. The bidirectional switching switch 26 can also be an electronic switch, and the switching between the sampling terminal 1 and the input terminal 2 of each bidirectional switching switch 26 can be controlled by the first controller 22 of the adapter 20.

[0074] In this embodiment, all sets of bidirectional switching switches 26 are electronic switches. The first controller 22 is communicatively connected to the multiple sets of bidirectional switching switches 26 and is used to control the switching of multiple bidirectional switching switches 26 in each set between their respective sampling terminals 1 and input terminals 2, and to cooperate with the closing or opening of the corresponding grounding switch 25, so as to continuously monitor the temperature of the patient's body surface detected by all temperature sensors 14 on the electrode pad 10 or to transmit AC signals to the patient. In this embodiment, the multiple sets of grounding switches 25 and the multiple sets of bidirectional switching switches 26 together form a switching unit (unlabeled).

[0075] In this embodiment, each set of analog-to-digital converters 23 is electrically connected to the sampling terminals 1 of multiple bidirectional switching switches 26 in the corresponding set of bidirectional switching switches 26 through multiple circuit lines (unlabeled) in the adapter 20, and is configured to receive the temperature detection signal transmitted by the multi-channel dual-purpose signal line 19 of the corresponding electrode pad 10, and convert the temperature detection signal from an analog signal to a digital signal. Each group of analog-to-digital converters 23 includes multiple detection channels A, B, C, D, and E. Each detection channel A, B, C, D, and E is used to connect to a corresponding dual-purpose signal line 19 in the multi-channel dual-purpose signal line 19 via a corresponding bidirectional switch 26. The number of detection channels in each group of analog-to-digital converters 23 is related to the number of bidirectional switches 26 in the corresponding group. The number of detection channels in each group of analog-to-digital converters 23 is related to the number of column groups of electrode units 12 in the corresponding electrode sheet 10. Specifically, the number of detection channels in each group of analog-to-digital converters 23 is equal to the number of bidirectional switches 26 in the corresponding group of bidirectional switches 26, and is not less than the number of column groups of electrode units 12 in the corresponding electrode sheet 10. As shown in Figure 3, each group of analog-to-digital converters 23 contains a total of 5 detection channels A, B, C, D, and E, which are respectively the first detection channel A, the second detection channel B, the third detection channel C, the fourth detection channel D, and the fifth detection channel E. The first detection channel A is connected to the first dual-purpose signal line 19-1 via the sampling terminal 1 of the first bidirectional switch 26-1; the second detection channel B is connected to the second dual-purpose signal line 19-2 via the sampling terminal 1 of the second bidirectional switch 26-2; the third detection channel C is connected to the third dual-purpose signal line 19-3 via the sampling terminal 1 of the third bidirectional switch 26-3; the fourth detection channel D is connected to the fourth dual-purpose signal line 19-4 via the sampling terminal 1 of the fourth bidirectional switch 26-4; and the fifth detection channel E is connected to the fifth dual-purpose signal line 19-5 via the sampling terminal 1 of the fifth bidirectional switch 26-5. Each detection channel A, B, C, D, and E is used to receive the temperature detection signal collected by the temperature sensor 14 of the electrode unit 12 connected to the corresponding dual-purpose signal line 19. Furthermore, each detection channel A, B, C, D, and E is connected to a corresponding branch within the adapter 20.Piezoresistor 24 is connected to a first power module 29 for providing detection voltage to detection channels A, B, C, D, and E. The first power module 29 provides DC signals.

[0076] In this embodiment, the first communication unit 27 is configured to acquire digital signals output by multiple sets of analog-to-digital converters 23 and send the digital signals to the electric field generator 30. The electric field generator 30 is also configured to control the voltage, current, or power of the AC signals provided to the multiple electrode units 12 of the electrode sheet 10 according to the received digital signals. (See page 14 / 34 of the instruction manual, 17 CN 120983810, Section A) For example, when any one of the received digital signals exceeds a preset threshold, it indicates that the temperature detected by at least one temperature sensor 14 in the electrode pad 10 at the corresponding dielectric element 15 applied to the human body surface exceeds the preset threshold temperature (e.g., 41°C, 42°C, etc.). In this case, the voltage, current, or power of the AC signal output by the electric field generator 30 can be appropriately reduced to prevent the electrode unit 12 of the electrode pad 10 from becoming too hot when the AC signal is applied, thus avoiding low-temperature burns to the patient's skin. The aforementioned preset threshold temperature and preset threshold can be determined based on human safety thresholds. The first communication unit 27 is controlled by the first controller 22 and serially transmits digital signals converted by multiple sets of analog-to-digital converters 23. In this embodiment, the preset temperature threshold can be a value within the range of 36°C to 45°C.

[0077] One end of each of the multiple communication transmission lines 211 embedded in the adapter 20 is connected to the first controller 22, and the other end is electrically connected to the communication line 172, which is electrically connected to the communication pin of the handshake chip 17 of the corresponding electrode 10, through the corresponding wire of the corresponding first cable 13. The ground pin GND of the adapter 22 is also connected to the corresponding wire of the corresponding first cable 13 through a wire electrically connected to the corresponding grounding switch 25, a grounding line 18 that is connected to both the corresponding wire of the corresponding first cable 13 and the grounding trace 171, and the grounding trace 171 that is shorted to the grounding line 18 to achieve the connection with the grounding pin of the handshake chip 17 of the corresponding electrode 10. That is, the first controller 22 controls the grounding switch 25 corresponding to the grounding line 18-4 that is short-circuited to the grounding pin of the handshake chip 17 of the electrode 10 to close, and sends a handshake communication signal to the communication line 172 of the electrode 17 through the communication transmission line 211. The first controller 22 determines whether the connection between the electrode 10 and the adapter 20 is normal based on whether the first controller 22 can receive the feedback from the communication line 172 of the electrode 10.

[0078] Referring to FIG4 and FIG5, in this embodiment, the first power module 29 is electrically connected to the second power module 31 of the electric field generator 30 and is configured to supply power to the first controller 22, multiple sets of analog-to-digital converters 23, and the first communication unit of the adapter 20.Power is supplied by Yuan 27. Each electrode 10 is connected to the adapter 20 by a first connector 40, which is adapted to connect the corresponding electrode 10 to the adapter 20. As shown in Figure 1, the first connector 40 includes a first plug 41 located at the end of the first cable 13 away from the electrode 10 and a first socket 42 located on the adapter 20. The first plug 41 and the first socket 42 are push-button spring connectors, that is, the first connector 40 connects the adapter 20 and the electrode 10 by means of a connector. Each first cable 13 has five wires electrically connected to bidirectional switch 26-1, 26-2, 26-3, 26-4, and 26-5 in the corresponding set of bidirectional switch 26; four wires electrically connected to grounding switch 25-1, 25-2, 25-3, and 25-4 in the corresponding set of grounding switch 25; and one wire electrically connected to both the communication line 172 of the electrode plate 10 and the communication transmission line 211 of the adapter 20. That is, each first connector 40 is electrically connected to a corresponding set of bidirectional switch 26, a corresponding set of grounding switch 25, and a corresponding communication transmission line 211 connected to the first controller 22 via ten wires; and is connected to the electric field generator 30 via a corresponding AC signal line 28 of the adapter 20.

[0079] A second connector 50 is provided between the adapter 20 and the electric field generator 30. The second connector 50 is adapted to connect the electric field generator 30 to the adapter 20. The adapter 20 also includes a second cable 21 connected to the second connector 50. The second connector 50 includes a second plug 51 located at the end of the second cable 21 away from the first controller 22 and a second socket 52 located on the electric field generator 30. The second plug 51 and the second socket 52 are push-button spring connectors, that is, the second connector 50 connects the adapter 20 and the electric field generator 30 by means of a connector. Each first connector 40, such as X1, Y1, X2, and Y2, is connected to the second connector 50 via a corresponding AC signal line 28. The first connectors 40, such as X1, Y1, X2, and Y2, are respectively connected to a corresponding set of grounding switches 25, a corresponding set of analog-to-digital converters 23, and a corresponding communication transmission line 211. Each first connector 40 is connected to the second connector 50 and the corresponding set of analog-to-digital converters 23 via a corresponding set of bidirectional switching switches 26. Taking four electrode plates 10 as an example, the second cable 21 has eight wires, including four wires 1 to 4 that are electrically connected to the corresponding AC signal lines 28 for transmitting AC signals, one wire 5 that is electrically connected to the receiving line RX of the first communication unit 27, one wire 6 that is electrically connected to the data transmitting line TX of the first communication unit 27, and one wire 7 that is electrically connected to the second communication unit 27.A wire 7 is electrically connected to the VCC power line of a power module 29, and a wire 8 is electrically connected to the GND line of the first power module 29. The second connector 50 is connected to the first communication unit 27 via a data receiving line RX and a data transmitting line TX. The VCC pin of the second connector 50 is connected to the VCC power line of the first power module 29, and the GND pin of the second connector 50 is connected to the GND line of the first power module 29 and grounded. The VCC pin of the second connector 50 is also connected to the corresponding group of voltage-reducing resistors 24 and the corresponding group of analog-to-digital converters 23 through the VCC power line of the first power module 29.

[0080] Referring to FIG5, the electric field generator 30 includes: a second power module 31, a second controller 32, an AC signal generator 34, a second communication unit 33, and a group of AC signal switches 35. The VCC pin of the second connector 50 is also electrically connected to the VCC power line of the second power module 31, and the GND pin of the second connector 50 is grounded through the GND line of the second power module 31. The second power module 31 is also connected to and supplies power to the second controller 32 and the AC signal generator 34, respectively. The second communication unit 33 is electrically connected to the wire 5 of the second connector 50 via its data receiving line RX and to the wire 6 of the second connector 50 via its data transmitting line TX, thereby realizing information interaction between the electric field generator 30 and the adapter 20. The second controller 32 is also electrically connected to the second communication unit 33, the AC signal generator 34, and a set of AC signal switches 35. The second controller 32 is configured to control the opening and closing of each AC signal switch 35 in the set of AC signal switches 35 and adjust the relevant parameters of the AC signal applied by the AC signal generator 34 according to the relevant digital signals received from the adapter 20 by the second communication unit 33. The relevant parameters of the AC signal include the voltage, current, and power of the AC signal. The AC signal generator 34 is electrically connected to several wires 1, 2, 3, and 4 of the second connector 50 for transmitting AC signals via a set of AC signal switches 35. A set of AC signal switches 35 includes multiple AC signal switches 35, and the multiple AC signal switches 35 are arranged one-to-one with multiple electrode plates 10. Each AC signal switch 35 is electrically connected to a corresponding wire 1, 2, 3, 4 in the second connector 50 through an AC signal wiring 36, and is also electrically connected to the corresponding electrode plate 10 through the corresponding wires 1, 2, 3, 4 in the second connector 50, so as to transmit an AC signal to each electrode plate 10. The AC signal generator 34 is electrically connected to the set of AC signal switches 35 through a set of AC signal wiring 36.

[0081] Specifically, the number of AC signal switches 35 in the electric field generator 30 is related to the number of electrode plates 10. In this embodiment, the number of AC signal switches 35 is equal to the number of electrode plates 10 and is 4 in each case. The AC signal switches 35 include a connection to the second connector 50.The wires 1 to 4 of the device 50 are respectively electrically connected to the first AC signal switch 35-1, the second AC signal switch 35-2, the third AC signal switch 35-3, and the fourth AC signal switch 35-4. One end of the first AC signal switch 35-1 is electrically connected to the AC signal generator 34 through the first AC signal wiring 36 of the electric field generator 30, and the other end is electrically connected to the corresponding AC signal transmission wire 1 in the second connector 50 through the first AC signal wiring 36-1, and then electrically connected to the AC signal line 28 located at port X1 of the adapter 20 through the wire 1 of the second connector 50. The AC signal line 28 located at port X1 of the adapter 20 is electrically connected to the first connector 40, and the first connector 40 located at port X1 of the adapter 20 is electrically connected to the corresponding electrode plate 10, so as to control whether the AC signal generator 34 transmits AC signal to the electrode plate 10 electrically connected to port X1 of the adapter 20; the second AC signal switch 35-2... One end of the third AC signal switch 35-3 is electrically connected to the AC signal generator 34 via the second AC signal wiring 36 of the electric field generator 30, and the other end is electrically connected to the corresponding AC signal transmission wire 2 in the second connector 50 via the second AC signal wiring 36-2. It is also electrically connected to the AC signal line 28 at port Y1 of the adapter 20 via the wire 2 of the second connector 50, the AC signal line 28 at port Y1 of the adapter 20, the first connector 40 at port Y1 of the adapter 20, and the corresponding electrode 10, thereby controlling whether the AC signal generator 34 supplies AC signals to the electrode 10 electrically connected to port Y1 of the adapter 20. One end of the third AC signal switch 35-3 is electrically connected to the AC signal generator 34 via the third AC signal wiring 36-3 of the electric field generator 30, and the other end is electrically connected to the corresponding AC signal transmission wire 36-2 in the second connector 50 via the AC signal wiring 36-3. The AC signal generator 34 is electrically connected to the AC signal line 28 at port X2 of the adapter 20 via the wire 3 of the second connector 50. The AC signal line 28 at port X2 of the adapter 20 is electrically connected to the first connector 40. The first connector 40 at port X2 of the adapter 20 is electrically connected to the corresponding electrode 10 to control whether the AC signal generator 34 transmits an AC signal to the electrode 10 electrically connected to port X2 of the adapter 20. One end of the fourth AC signal switch 35-4 is electrically connected to the AC signal generator 34 via the fourth AC signal wiring 36-4 of the electric field generator 30, and the other end is electrically connected to the corresponding AC signal transmission wire 4 in the second connector 50 via the fourth AC signal wiring 36-4, and to the adapter 20 at port Y2 via the wire 4 of the second connector 50.The AC signal line 28 at port Y2 of the adapter 20 is electrically connected to the first connector 40, and the first connector 40 at port Y2 of the adapter 20 is electrically connected to the corresponding electrode 10, so as to control whether the AC signal generator 34 transmits AC signal to the electrode 10 electrically connected to port Y1 of the adapter 20.

[0082] The working principle of the handshake chip 17 is described in detail below. The handshake chip 17 can store electrical energy when the communication line 172 transmits a high level through an external energy storage element (not shown), and release energy when the communication line 172 transmits a low level, so that the handshake chip 17 can obtain enough power and work normally. Optionally, the energy storage element is a capacitor. In this way, the handshake chip 17 only needs an extra communication core wire to work normally. The handshake chip 17 is adapted to communicate with external devices such as the electric field generator 30 or the adapter 20 to determine the connection status of each pair of electrode plates 10. After the handshake chip 17 completes the handshake communication with the adapter 20 and / or the electric field generator 30, the states of the bidirectional switching switch 26 and the grounding switch 25 can be combined to enable the electrode plate 10 to apply an AC signal or perform temperature acquisition. When the electrode plate 10 needs to perform temperature acquisition or measurement, all the bidirectional switching switches 26 on the flexible circuit board 11 of the electrode plate 10 are located at the sampling end 1. The electric field generator 30 or the adapter 20 can sequentially close each grounding switch 25 so that the analog temperature signal of the corresponding temperature sensor 14 in each row group is simultaneously sampled by the corresponding temperature sampling point. The analog temperature signal detected by each sampled temperature sensor 14 can also be converted into a signal that can characterize the type of electrode plate 10 if the electrode plate 10 is qualified, or it can be used to characterize whether the electrode plate 10 has a temperature anomaly.

[0083] Specifically, when the first controller 22 of the adapter 20 receives the handshake signal sent by the electric field generator 30, it controls the corresponding grounding switch 25 connected to the grounding pin of the handshake chip 17 to close, so that the handshake chip 17 is powered on and sends the handshake signal to the handshake chip 17. The handshake chip 17 sends a feedback signal, and the first controller 22 on the adapter 20 sends the feedback signal of the handshake chip 17 to the second controller 32 of the electric field generator 30 through the second connector 50. The second controller 32 determines whether the corresponding first controller 22 and the handshake chip 17 have completed handshake communication according to the feedback signal of the handshake chip 17, and after completing the handshake communication, it configures the state of each grounding switch 25 and each bidirectional switching switch 26 in the switch unit (unlabeled) on the adapter 20 to transmit AC signals to the dielectric elements of each electrode unit 12 of the electrode sheet 10 or to measure the temperature through the temperature sensor 14 of each electrode unit 12 of the electrode sheet 10. When the electrode plate 10 is in temperature acquisition mode, the electric field generator 30 controls each bidirectional switch 26 of the adapter 20 through its second controller 32 to ensure that each bidirectional switch 26 is in the appropriate state.Each of the acquisition terminals 1 and the grounding switches 25 are closed in sequence, so that the detection channels of the corresponding analog-to-digital converters 23 acquire the temperature detection signals of each temperature sensor 14 in a row, and perform analog-to-digital conversion on the acquired several temperature analog signals to obtain several AD sampling values, which correspond to digital temperature. The first controller 22 can also send several AD sampling values ​​to the electric field generator 30 through the adapter 20, so that if the electrode 10 is qualified, the electric field generator 30 can identify the type of the corresponding electrode 10 according to several AD sampling values, and / or, in the process of transmitting alternating electrical signals to the corresponding electrode 10, determine whether the corresponding electrode 10 has a temperature abnormality according to several AD sampling values.

[0084] The working principle of the tumor electric field therapy system 100 of this embodiment will be described in detail below with reference to Figures 3 to 5.

[0085] The second controller 32 of the electric field generator 30 controls the grounding switch 25-4 corresponding to the fourth grounding line 18-4 connected to the handshake chip 17 of the electrode 10 to be in a closed state through the first controller 22 of the adapter 20, and sends a handshake signal to the communication line 172 of the electrode 10 through the first controller 22, and determines the connection status between the electrode 10 and the adapter 20 based on whether feedback from the handshake chip 17 can be received. If the electric field generator 30 can receive feedback from the electrode 10, it indicates that the connection between the electrode 10 and the adapter 20 is normal; then AC power signals can be applied to the electrode 10 or temperature detection signals can be collected through the temperature sensor 14 of the electrode 10. If the electric field generator 30 does not receive feedback from the electrode 10, it indicates that the connection between the electrode 10 and the adapter 20 is abnormal, and the second controller 32 of the electric field generator 30 issues a connection abnormality prompt to remind the operator. After the operator handles the situation, the second controller 32 continues to control the first controller 22 of the adapter 20 to send a handshake communication signal to the handshake chip 17 of the electrode 10, repeating the above-mentioned operation of judging the connection status of the electrode 10 until the electrode 10 and the adapter 20 are normally connected.

[0086] When the electrode 10 is normally connected and it is necessary to detect the temperature of each electrode unit 12 of a certain electrode 10, the first controller 22 of the adapter 20 or the second controller 32 of the electric field generator 30 controls the sampling terminal 1 of each of the multiple bidirectional switching switches 26 electrically connected to the electrode 10 to be turned on and the input terminal 2 to be turned off, so as to disconnect the AC signal applied to the electrode 10; at the same time, the first controller 22 of the adapter 20 or the second controller 32 of the electric field generator 30 controls each of the grounding switches 25 electrically connected to the electrode 10 to be turned on in sequence.During time-division multiplexing, the temperature detection signals collected by the temperature sensors 14 of each electrode unit 12 in each row of the electrode sheet 10 can be sequentially acquired through multiple detection channels A, B, C, D, and E of a set of analog-to-digital converters 23 corresponding to the electrode sheet 10. Each detection channel A, B, C, D, and E of each set of analog-to-digital converters 23 acquires only the temperature detection signal of the temperature sensor 14 of the corresponding electrode unit 12 in the same row of the electrode sheet 10 at any given time. These temperature detection signals can be characterized by voltage values. Only one of the four grounding switches 25 in the set corresponding to the electrode sheet 10 can be on at any given time, while the other three are off. All five bidirectional switches 26 of a set of bidirectional switches 26 corresponding to the group of analog-to-digital converters 23 are switched to their respective sampling terminals 1 so that each dual-purpose signal line 19 of the electrode plate 10 is electrically connected to the corresponding detection channels A, B, C, D, and E of the corresponding analog-to-digital converter 23 and thus conducts. With this configuration, the group of analog-to-digital converters 23 can collect the voltage values ​​of all temperature sensors 14 of each electrode unit 12 in the same row group that are shorted by a grounding line 18 corresponding to the conducting grounding switch 25.

[0087] Specifically, when the first grounding switch 25-1 is closed, the second grounding switch 25-2, the third grounding switch 25-3, and the fourth grounding switch 25-4 are all open, and the first bidirectional switching switch 26-1, the second bidirectional switching switch 26-2, the third bidirectional switching switch 26-3, the fourth bidirectional switching switch 26-4, and the fifth bidirectional switching switch 26-5 are all switched to their respective sampling terminals 1, the temperature sensors 14 of the electrode units 12-1 to 12-5 of the first row group are energized, and the electrode units 12-6 of the remaining row groups are energized. When the temperature sensors 14 of electrode units 12-20 are de-energized, the signal terminals 14-2 of the temperature sensors 14 of electrode units 12-1, 12-6, 12-11, and 12-16 are shorted on the first detection channel A of the analog-to-digital converter 23. Since only the ground terminal 14-1 of the temperature sensor 14 of electrode unit 12-1 is connected to ground, while the ground terminals 14-1 of the temperature sensors 14 of electrode units 12-6, 12-11, and 12-16 are disconnected, and each electrode unit 12 is provided with a diode 16 connected in series with the temperature sensor 14, the other temperature sensors 14 in the first row will not affect the resistance value of the temperature sensor 14 of electrode unit 12-1. Therefore, only the temperature sensor 14 of electrode unit 12-1 is effectively operating on the first detection channel A of the analog-to-digital converter 23, and the temperature detection signal (voltage value) collected by the first detection channel A is the voltage value of the temperature sensor 14 of electrode unit 12-1. Similarly, on the second detection channel B of this group of analog-to-digital converters 23The voltage value collected is the voltage value of temperature sensor 14 in electrode unit 12-2. The voltage value collected on the third detection channel C of this group of analog-to-digital converters 23 is the voltage value of temperature sensor 14 in electrode unit 12-3. The voltage value collected on the fourth detection channel D of this group of analog-to-digital converters 23 is the voltage value of temperature sensor 14 in electrode unit 12-4. The voltage value collected on the fifth detection channel E of this group of analog-to-digital converters 23 is the voltage value of temperature sensor 14 in electrode unit 12-5.

[0088] When the second grounding switch 25-2 is closed, the first grounding switch 25-1, the third grounding switch 25-3, and the fourth grounding switch 25-4 are all open, and the first bidirectional switching switch 26-1, the second bidirectional switching switch 26-2, the third bidirectional switching switch 26-3, the fourth bidirectional switching switch 26-4, and the fifth bidirectional switching switch 26-5 are all switched to their respective sampling terminals 1, the temperature sensors 14 of the electrode units 12-6 to 12-10 in the second row group are energized, and the temperature sensors 14 of the electrode units 12-1 to 12-5 and the electrode units 12-11 to 12-20 in the other row groups are de-energized. Electrode units 12-1, 12-6, 12-11, and 12-20 are short-circuited on the first detection channel A of the analog-to-digital converter 23 in this group. Since only the grounding terminal 14-1 of the temperature sensor 14 of electrode unit 12-6 is grounded, while the grounding terminals 14-1 of the temperature sensors 14 of electrode units 12-1, 12-11, and 12-16 are disconnected, and each electrode unit 12 has a diode 16 connected in series with the temperature sensor 14, the other temperature sensors 14 in the second row will not affect the resistance value of the temperature sensor 14 of electrode unit 12-6. Therefore, only the temperature sensor 14 of electrode unit 12-6 is effectively operating on the first detection channel A of this group of analog-to-digital converters 23. At this time, the temperature detection signal (voltage value) collected by the first detection channel A is the voltage value of the temperature sensor 14 of electrode unit 12-6. Similarly, the voltage value collected on the second detection channel B of this group of analog-to-digital converters 23 is the voltage value of the temperature sensor 14 of electrode unit 12-7. The voltage value acquired on the third detection channel C of this group of analog-to-digital converters 23 is the voltage value of the temperature sensor 14 of electrode unit 12-8. The voltage value acquired on the fourth detection channel D of this group of analog-to-digital converters 23 is the voltage value of the temperature sensor 14 of electrode unit 12-9. The voltage value acquired on the fifth detection channel E of this group of analog-to-digital converters 23 is the voltage value of the temperature sensor 14 of electrode unit 12-10.

[0089] When the third grounding switch 25-3 is closed, and the first grounding switch 25-1, the second grounding switch 25-2, and the fourth grounding switch 25-4 are all open, and the first bidirectional switching switch 26-1, the second bidirectional switching switch 26-2, the third bidirectional switching switch 26-3, the fourth bidirectional switching switch 26-4, and the fifth bidirectional switching switch 26-5 are all switched to their respective sampling terminals 1, the temperature sensors 14 of the electrode units 12-11 to 12-15 in the third row are energized, while the temperature sensors 14 of the electrode units 12-11 to 12-10 and the electrode units 12-16 to 12-20 in the other rows are de-energized. The signal terminals 14-2 of the temperature sensors 14 of the electrode units 12-1, 12-6, 12-11, and 12-16 in the first detection channel A of the analog-to-digital converter 23 are shorted. Since only the temperature sensor 14 of electrode unit 12-11... The grounding terminal 14-1 of electrode unit 12-1 is connected to ground, while the grounding terminals 14-1 of the temperature sensors 14 of electrode units 12-1, 12-6, and 12-16 are disconnected. Each electrode unit 12 has a diode 16 connected in series with the temperature sensor 14. The other temperature sensors 14 in the third row do not affect the resistance of the temperature sensor 14 in electrode unit 12-11. Therefore, only the temperature sensor 14 of electrode unit 12-11 is effectively operating on the first detection channel A of this group of analog-to-digital converters 23. At this time, the temperature detection signal (voltage value) collected by the first detection channel A is the voltage value of the temperature sensor 14 in electrode unit 12-11. Similarly, the voltage value collected on the second detection channel B of this group of analog-to-digital converters 23 is the voltage value of the temperature sensor 14 in electrode unit 12-12. The voltage value collected on the third detection channel C of this group of analog-to-digital converters 23 is the voltage value of the temperature sensor 14 in electrode unit 12-13. The voltage value collected on the fourth detection channel D in this group of analog-to-digital converters 23 is the voltage value of the temperature sensor 14 of electrode unit 12-14. The voltage value collected on the fifth detection channel E in this group of analog-to-digital converters 23 is the voltage value of the temperature sensor 14 of electrode unit 12-15.

[0090] When the fourth grounding switch 25-4 is closed, the first grounding switch 25-1, the second grounding switch 25-2 and the third grounding switch 25-3 are all open, and the first bidirectional switching switch 26-1, the second bidirectional switching switch 26-2, the third bidirectional switching switch 26-3, the fourth bidirectional switching switch 26-4 and the fifth bidirectional switching switch 26-5 are all switched to their respective sampling terminals 1, the temperature sensors 14 of electrode units 12-16 to 12-20 in the fourth row group are energized, and the temperature sensors 14 of electrode units 12-11 to 12-15 in the other rows group are de-energized. The electrode unit in the first detection channel A of this group of analog-to-digital converters 23 is short-circuited.The signal terminals 14-14 of the temperature sensors 14 of each of electrode units 12-1, 12-6, 12-11, and 12-16 are connected to ground, while the ground terminals 14-14 of the temperature sensors 14 of each of electrode units 12-1, 12-6, and 12-11 are disconnected. Furthermore, each electrode unit 12 has a diode 16 connected in series with the temperature sensor 14. The remaining temperature sensors 14 in the fourth row do not affect the resistance of the temperature sensors 14 of electrode units 12-16. Therefore, only the temperature sensors 14 of electrode units 12-16 are effectively operating on the first detection channel A of this group of analog-to-digital converters 23. At this time, the temperature detection signal (voltage value) collected by the first detection channel A is the voltage value of the temperature sensors 14 of electrode units 12-16. Similarly, the voltage value collected on the second detection channel B of the analog-to-digital converter 23 is the voltage value of the temperature sensor 14 of electrode unit 12-17. The voltage value collected on the third detection channel C of the analog-to-digital converter 23 is the voltage value of the temperature sensor 14 of electrode unit 12-18. The voltage value collected on the fourth detection channel D of the analog-to-digital converter 23 is the voltage value of the temperature sensor 14 of electrode unit 12-19. The voltage value collected on the fifth detection channel E of the analog-to-digital converter 23 is the voltage value of the temperature sensor 14 of electrode unit 12-20. Thus, the first controller 22 of the adapter 20 or the second controller 32 of the electric field generator 30 can collect the temperature detection signals of the temperature sensors 14 of all electrode units 12 of a certain electrode piece 10 by controlling a set of bidirectional switching switches 26 and a set of grounding switches 25, all of which are electrically connected to a certain electrode piece 10. Similarly, the temperature detection signals of the temperature sensors 14 of each electrode unit 12 of other electrode pieces 10 can be obtained.

[0091] The first controller 22, multiple sets of analog-to-digital converters 23, and multiple sets of bidirectional switching switches 26 can automatically perform operations through pre-programmed program code. For example, the first controller 22 first controls all bidirectional switching switches 26 in the corresponding set to switch to the sampling terminal 1, so that the sampling terminals 1 of these bidirectional switching switches 26 are all turned on and the input terminals 2 are all turned off, so that each dual-purpose signal line 19 of the corresponding electrode plate 10 is electrically connected to the corresponding set of analog-to-digital converters 23. Then, it closes the first grounding switch 25-1 in the corresponding set of grounding switches 25, and disconnects the remaining second grounding switches 25-2, third grounding switches 25-3 to fourth grounding switches 25-4 in the set of grounding switches 25. During this period, each detection channel A, B, C of the set of analog-to-digital converters 23 is connected.D and E acquire the temperature detection signals of each temperature sensor 14 of each electrode unit 12 located in the first row group of the corresponding electrode sheet 10, convert them into digital signals, and store them in a separately set memory. Then, after a preset interval, the first controller 22 closes the second grounding switch 25-2 in the group of grounding switches 25, and opens the first grounding switch 25-1, the third grounding switch 25-3, and the fourth grounding switch 25-4 in the group of grounding switches 25. During this period, the detection channels A, B, C, D, and E of the group of analog-to-digital converters 23 acquire the temperature detection signals of each temperature sensor 14 of each electrode unit 12 located in the second row group. By sequentially turning on each grounding switch 25 in the group of grounding switches 25, the temperature detection signals of all temperature sensors 14 in each row group of the electrode sheet 10 can be obtained. Similarly, through this operation, the temperature detection signals of all temperature sensors 14 on at least one pair of electrode sheets 10 can be obtained.

[0092] The tumor electric field therapy system 100 of this application can achieve real-time and comprehensive monitoring of the temperature of all electrode units 12 on the electrode sheet 10 without increasing the weight of the electrode sheet 10 or the number of wire cores of the first cable 13 electrically connected to the electrode sheet 10. It can then determine whether the electrode sheet 10 is qualified based on the obtained temperature detection signal; or determine whether the temperature sensor 14 of the electrode sheet 10 is faulty or abnormal based on the obtained temperature detection signal, and determine whether the electrode sheet 10 needs to be replaced based on the number of faulty or abnormal temperature sensors 14; or identify the electrode sheet type based on the obtained temperature detection signal if the electrode sheet is qualified; or determine whether the electrode unit 12 of the electrode sheet 10 is overheated based on the obtained temperature detection signal if the electrode sheet is qualified, and then control the alternating electrical signal applied to the electrode sheet 10 or the corresponding column of electrode units 12 of the electrode sheet 10, thereby avoiding low-temperature burns to the patient's body surface during tumor treatment through the electrode sheet 10. Furthermore, the flexible circuit board 11 of the electrode sheet 10 of this application is electrically connected to the dielectric element 15 of the same electrode unit 12 and the signal terminal 14-2 of the temperature sensor 14 through the same dual-purpose signal line 19. While enabling the transmission of both AC and DC signals for temperature signal acquisition (as described on page 20 / 34 of the specification, CN 120983810 A) and the acquired temperature detection signal via the dual-purpose signal line 19, it also significantly reduces the number of conductive traces (grounding line 18, dual-purpose signal line 19) laid on it, reducing the wiring difficulty of the flexible circuit board 11, simplifying the manufacturing process, reducing the weight of the flexible circuit board 11, and lowering manufacturing costs. The electrode sheet 10 of this application can also be connected via a combination of a grounding switch 25 electrically connected to the grounding line 18 and a bidirectional switching switch 26 electrically connected to the dual-purpose signal line 19.The control enables the switching between applying an AC signal for tumor treatment and transmitting a DC signal for temperature acquisition and transmitting the acquired temperature detection signal.

[0093] When the electrode pad 10 is properly connected and it is necessary to apply an AC signal to the patient through each electrode unit 12 of a certain electrode pad 10, the first controller 22 of the adapter 20 or the second controller 32 of the electric field generator 30 controls all the grounding switches 25 in a set of grounding switches 25 corresponding to the electrode pad 10 to be disconnected, and at the same time controls all the bidirectional switching switches 26 in a set of bidirectional switching switches 26 corresponding to the electrode pad 10 to be switched to their respective input terminals 2, so that the sampling terminals 1 of these bidirectional switching switches 26 are all disconnected and the input terminals 2 are all turned on, so that each dual-purpose signal line 19 of the electrode pad 10 is electrically connected to an AC signal line 28 corresponding to the adapter 20 and the electrode pad 10, thereby transmitting the AC signal to each electrode unit 12 of the electrode pad 10. When the temperature detection signals of the temperature sensors 14 of all electrode units 12 of the detected electrode plate 10 are much lower than the preset temperature threshold stored in the electric field generator 30 or the adapter 20, the electric field generator 30 controls the AC signal generator 34 through its second controller 32 to continue generating an AC signal with an increased voltage or current amplitude or a constant voltage or current amplitude. This signal is then transmitted to the corresponding electrode plate 10 through a corresponding AC signal line 28 of the adapter 20, so that the electrode plate 10 continues to receive an AC signal. When the temperature detection signals of the temperature sensors 14 of all electrode units 12 of the detected electrode plate 10 are lower than but close to the preset temperature threshold stored in the electric field generator 30 or the adapter 20, the electric field generator 30 can reduce the voltage or current of the AC signal generated by the AC signal generator 34 through the second controller 32, thereby reducing the voltage or current of the AC signal applied to the electrode plate 10. When the temperature detection signal of the temperature sensor 14 of one electrode unit 12 of a detected electrode plate 10 is greater than the preset temperature threshold, the electric field generator 30 controls the AC signal generated by the temperature sensor 14 of that electrode unit 12 through the second controller 32. The AC signal switch 35 electrically connected to electrode 10 is disconnected to stop applying an AC signal to the electrode 10; or the second controller 32 of the electric field generator 30 or the first controller 22 of the adapter 20 controls all bidirectional switching switches 26 in a set of bidirectional switching switches 26 electrically connected to the electrode 10 to switch from their input terminals 2 to their sampling terminals 1, that is, controls all bidirectional switching sampling terminals 1 of all bidirectional switching switches 26 in a set of bidirectional switching switches 26 electrically connected to the electrode 10 to be turned on and all input terminals 2 to be turned off, thereby stopping the application of an AC signal to the electrode 10 for a time limit; or, when the temperature detection signal of the temperature sensor 14 of an electrode unit 12 on a certain electrode 10 is detected to be greater than a preset temperature threshold, the second controller 32 of the electric field generator 30 controls the AC signal switch 35 ... switch from its input terminal 2 to its sampling terminal 1, that is, controls all bidirectional switching sampling terminals 1 to be turned on and all input terminals 2 to be turned off, thereby stopping the application of an AC signal to the electrode 10 for a time limit.The AC signal switch 35 electrically connected to the electrode 10 remains on, and the second controller 32 of the electric field generator 30 or the first controller 22 of the adapter 20 controls a bidirectional switching switch 26 electrically connected to the electrode unit 12 of the electrode 10 to switch from its input terminal 2 to its sampling terminal 1. Simultaneously, the second controller 32 of the electric field generator 30 or the first controller 22 of the adapter 20 controls the remaining bidirectional switching switches 26 electrically connected to electrode units 12 in different columns from those whose temperature detection signals exceed the preset temperature threshold, ensuring their respective input terminals 2 remain electrically connected. This stops applying AC signals to all electrode units 12 in the column where the temperature detection signals exceed the preset temperature threshold, and continues applying AC signals to the remaining columns of electrode units 12 whose temperature detection signals do not exceed the preset temperature threshold. This achieves a control method for regional application of AC signals based on temperature detection signals in the tumor electric field therapy system 100. When an AC signal is applied, all grounding switches 25 are disconnected.

[0094] In this embodiment, the grounding switches 25 that are electrically connected to the multiple grounding lines 18 of the electrode plate 10 and the bidirectional switching switches 26 that are electrically connected to the multiple dual-purpose signal lines 19 of the electrode plate 10 are all located in the adapter 20. However, in other embodiments, the grounding switches 25 that are electrically connected to the grounding lines 18 and the bidirectional switching switches 26 that are electrically connected to the dual-purpose signal lines 19 can also be located on the electrode plate 10 or in the electric field generator 30, which will not be described in detail here. In addition, the analog-to-digital converter 23 located in the adapter 20 can also be located in the electric field generator 30 and directly controlled by the second controller 32.

[0095] This application also provides other embodiments of the electrode plate 10. The main differences between the multiple embodiments are the number of electrode units 12 and / or the circuit distribution of the electrode units 12, which will be described below.

[0096] Figure 6 is a circuit connection diagram of the tumor electric field therapy system used in the second embodiment of this application, showing the circuit connection diagram between the electrode sheet 10D of the second embodiment and the adapter 20 of the first embodiment shown in Figure 1. The circuit is described below using the electrode sheet 10D of the second embodiment as an example. In terms of electrical connection, the electrode sheet 10D differs from the electrode sheet 10 of the first embodiment in the number of electrode units 12 and the circuit arrangement. The electrode sheet 10D in this embodiment has 13 of the aforementioned electrode units 12. In terms of electrical connection, the flexible circuit board 11D of the electrode sheet 10D arranges these 13 electrode units 12 in three rows and five columns in the circuit, where each of the two rows has 5 electrode units 12, and the remaining row has 3 electrode units 12.Yuan 12. The flexible circuit board 11D of the electrode sheet 10D is embedded with 3 grounding lines 18, 5 dual-purpose signal lines 19, 1 grounding trace 171 that is connected to the grounding pin of the handshake chip 17 and any grounding line 28, and 1 communication line 172 that is connected to the communication pin of the handshake chip 17. Each grounding line 18 is used to ground the grounding terminal 14-1 of the temperature sensor 14 of each electrode unit 12 in the corresponding row group. Each dual-purpose signal line 19 is short-circuited to the dielectric element 15 of each electrode unit 12 in each column group and the signal terminal 14-2 of each temperature sensor 14, for receiving temperature detection signals or transmitting AC signals. One grounding line 18 connected to the grounding trace 171 also grounds the grounding pin of the handshake chip 17.

[0097] The 3 grounding lines 18 of the flexible circuit board 11D are the first grounding line 18-1, the second grounding line 18-2 and the third grounding line 18-3. In the three rows of electrode sheet 10D, the first row includes electrode units 12-1 to 12-5, the second row includes electrode units 12-6 to 12-10, and the third row includes electrode units 12-11 to 12-13. Specifically, the first grounding wire 18-1 is used to ground the grounding terminals 14-1 of the temperature sensors 14 of each electrode unit 12-1 to 12-5 in the first row; the second grounding wire 18-2 is used to ground the grounding terminals 14-1 of the temperature sensors 14 of each electrode unit 12-6 to 12-10 in the second row; and the third grounding wire 18-3 is used to ground the grounding terminals 14-1 of the temperature sensors 14 of each electrode unit 12-11 to 12-13 in the third row and is also used to ground the grounding pin of the handshake chip 17 through the grounding trace 171 connected to the grounding pin of the handshake chip 17. In short, each grounding line 18 shorts and grounds the grounding terminals 14-1 of the temperature sensors 14 of all electrode units 12 in the corresponding row group, and one of the grounding lines 18 also shorts and grounds the grounding pin of the handshake chip 17.

[0098] The five dual-purpose signal lines 19 of the electrode sheet 10D include a first dual-purpose signal line 19-1, a second dual-purpose signal line 19-2, a third dual-purpose signal line 19-3, a fourth dual-purpose signal line 19-4, and a fifth dual-purpose signal line 19-5. One end of the first dual-purpose signal line 19-1 is simultaneously connected to the dielectric element 15 of each of the three electrode units 12 (electrode unit 12-1, electrode unit 12-6, and electrode unit 12-11) and the signal terminal 14-2 of each of their respective temperature sensors 14; one end of the second dual-purpose signal line 19-2 is simultaneously connected to the dielectric element 15 of each of the three electrode units 12-2, electrode unit 12-7, and electrode unit 12-12 and the signal terminal 14-2 of each of their respective temperature sensors 14; one end of the third dual-purpose signal line 19-3 is simultaneously connected to the electrode units...The dielectric element 15 of each of the three electrode units 12 (12-3, 12-8, and 12-13) and the signal terminal 14-2 of each of their respective temperature sensors 14 are connected simultaneously. One end of the fourth dual-purpose signal line 19-4 is connected to the dielectric element 15 of each of the two electrode units 12 (12-4 and 12-9) and the signal terminal 14-2 of each of their respective temperature sensors 14. One end of the fifth dual-purpose signal line 19-5 is connected to the dielectric element 15 of each of the two electrode units 12 (12-5 and 12-10) and the signal terminal 14-2 of each of their respective temperature sensors 14. In short, each dual-purpose signal line 19 shorts in parallel the dielectric element 15 and the signal terminal 14-2 of each of the electrode units 12 in a row, as described on pages 22 / 34 of the specification (CN 120983810 A), and connects them to the adapter 20.

[0099] The first grounding switch 25-1, the second grounding switch 25-2, and the third grounding switch 25-3 on the adapter 20 are electrically connected to the first grounding wire 18-1, the second grounding wire 18-2, and the third grounding wire 18-3 of the electrode plate 10D respectively via the first connector 40D. The fourth grounding switch 25-4 is in an idle and disconnected state. The first bidirectional switching switch 26-1, the second bidirectional switching switch 26-2, the third bidirectional switching switch 26-3, the fourth bidirectional switching switch 26-4, and the fifth bidirectional switching switch 26-5 on the adapter 20 are electrically connected to the first dual-purpose signal line 19-1, the second dual-purpose signal line 19-2, the third dual-purpose signal line 19-3, the fourth dual-purpose signal line 19-4, and the fifth dual-purpose signal line 19-5 of the electrode plate 10D respectively via the first connector 40D. A communication transmission line 211 on the adapter 20 is electrically connected to a communication line 172 connected to the communication pin of the handshake chip 17 of the electrode 10D.

[0100] The working mode of the tumor electric field therapy system formed by the electrode 10D, the adapter 20 and the electric field generator 30 is the same as that of the aforementioned tumor electric field therapy system 100. The second controller 32 of the electric field generator 30 sends a handshake communication signal to the first controller 22 of the adapter 20, and closes the third grounding switch 25-3 electrically connected to the handshake chip 17 of the electrode 10 through the first controller 22 of the adapter 20 or by directly controlling it. The handshake chip 17 is powered on. At this time, the first controller 22 sends a handshake communication signal to the handshake chip, and confirms that the electrode 10 is connected normally after receiving the feedback signal from the handshake chip 17. If no feedback signal is received from the handshake chip 17, the electrode 10 is confirmed to be connected abnormally. When electrode 10 is properly connected, the electric field transmitter 30 or adapter 20 controls 1) all grounding switches 25 to be disconnected and the input terminals 2 and sampling terminals 1 of all bidirectional switching switches 26 to be turned on.Disconnect to make all dual-purpose signal lines 19 and AC signal lines 28 conduct, at which time all electrode units 12 of electrode sheet 10 can apply AC signals; 2) turn on the sampling terminal 1 and turn off the input terminal 2 of all bidirectional switching switches 26, and turn on each grounding switch 25 in sequence to obtain the temperature detection signal of the temperature sensor 14 of each electrode unit 12 of each row group of electrode sheet 10 in sequence. Among them, no operation is required for the grounding switch 25 in the idle disconnected state.

[0101] Referring to FIG7, it is a circuit connection diagram of the tumor electric field therapy system of the third embodiment of this application, showing a circuit connection diagram of the electrode sheet 10E of the third embodiment and the adapter 20 shown in FIG1. The electrode sheet 10E, like the electrode sheet 10D in the second embodiment, has 13 electrode units 12, but the specific circuit layout is different. The flexible circuit board 11E of the electrode sheet 10E also arranges these 13 electrode units 12 in three rows and five columns, except that two of the rows each have 4 electrode units 12, and the remaining row has 5 electrode units 12. The flexible circuit board 11E of the electrode sheet 10E also embeds 3 ground lines 18, 5 dual-purpose signal lines 19, 1 ground trace 171 that is simultaneously connected to the ground pin of the handshake chip 17 and any ground line 28, and 1 communication line 172 that is connected to the communication pin of the handshake chip 17. Each grounding wire 18 is used to ground the grounding terminal 14-1 of the temperature sensor 14 of each electrode unit 12 in the corresponding row group. Each dual-purpose signal line 19 is used to short-circuit the dielectric element 15 of each electrode unit 12 and the signal terminal 14-2 of each temperature sensor 14 in each column group, for receiving temperature detection signals or transmitting AC signals. One grounding wire 18 connected to the grounding trace 171 also grounds the grounding pin of the handshake chip 17.

[0102] The three grounding wires 18 of the electrode sheet 10E include a first grounding wire 18-1, a second grounding wire 18-2 and a third grounding wire 18-3. The first row group includes electrode units 12-1 to 12-4, the second row group includes electrode units 12-5 to 12-8, and the third row group includes electrode units 12-9 to 12-13. Specifically, the first grounding wire 18-1 is used to ground the grounding terminals 14-1 of the temperature sensors 14 of each electrode unit 12-1 to electrode unit 12-4 in the first row group; the second grounding wire 18-2 is used to ground the grounding terminals 14-1 of the temperature sensors 14 of each electrode unit 12-5 to electrode unit 12-8 in the second row group; the third grounding wire 18-3 is used to ground the grounding terminals 14-1 of the temperature sensors 14 of each electrode unit 12-9 to electrode unit 12-13 in the third row group, and the grounding trace is connected to the grounding pin of the handshake chip 17. (Page 23 / 34, CN 120983810 A)171 grounds the ground pin of the handshake chip 17. In short, each ground line 18 shorts and grounds the ground terminals 14-1 of the temperature sensors 14 of all electrode units 12 in each row group, and one of the ground lines 18 also shorts and grounds the ground pin of the handshake chip 17.

[0103] The five dual-purpose signal lines 19 of the electrode sheet 10E include a first dual-purpose signal line 19-1, a second dual-purpose signal line 19-2, a third dual-purpose signal line 19-3, a fourth dual-purpose signal line 19-4, and a fifth dual-purpose signal line 19-5. The first dual-purpose signal line 19-1... One end of the first dual-purpose signal line 19-2 is simultaneously connected to the dielectric element 15 of each of the three electrode units 12 (electrode unit 12-1, electrode unit 12-5, and electrode unit 12-9) and the signal terminal 14-2 of their respective temperature sensors 14; one end of the second dual-purpose signal line 19-2 is simultaneously connected to the dielectric element 15 of each of the three electrode units 12 (electrode unit 12-2, electrode unit 12-6, and electrode unit 12-10) and the signal terminal 14-2 of their respective temperature sensors 14; one end of the third dual-purpose signal line 19-3 is simultaneously connected to the electrode unit 12-3, electrode unit 12-5, and electrode unit 12-9. Each of the three electrode units 12 (electrode units 12-7, 12-11) has its dielectric element 15 and its temperature sensor 14 signal terminal 14-2 connected to both the dielectric element 15 and the temperature sensor 14 signal terminal 14-2 of each of the three electrode units 12 (electrode units 12-4, 12-8, 12-12). One end of the fourth dual-purpose signal line 19-4 is simultaneously connected to both the dielectric element 15 and the temperature sensor 14 signal terminal 14-2 of each of the three electrode units 12 (electrode units 12-4, 12-8, 12-12). One end of the fifth dual-purpose signal line 19-5 is simultaneously connected to both the dielectric element 15 and the temperature sensor 14 signal terminal 14-2 of each electrode unit 12 (12-13). In short, each dual-purpose signal line 19 short-circuits the dielectric element 15 and the temperature sensor 14 signal terminal 14-2 of each electrode unit 12 located in a corresponding column group and connects them to the adapter 20.

[0104] The first grounding switch 25-1, the second grounding switch 25-2, and the third grounding switch 25-3 on the adapter 20 are electrically connected to the first grounding wire 18-1, the second grounding wire 18-2, and the third grounding wire 18-3 of the electrode plate 10E respectively via the first connector 40E. The fourth grounding switch 25-4 is in an idle and disconnected state. The first bidirectional switching switch 26-1, the second bidirectional switching switch 26-2, the third bidirectional switching switch 26-3, the fourth bidirectional switching switch 26-4, and the fifth bidirectional switching switch 26-5 on the adapter 20 are electrically connected to the first dual-purpose signal line 19-1, the second dual-purpose signal line 19-2, the third dual-purpose signal line 19-3, the fourth dual-purpose signal line 19-4, and the fifth dual-purpose signal line 19-5 of the electrode plate 10E respectively via the first connector 40E. A communication transmission line 211 on the adapter 20 is a communication line connected to the communication pin of the handshake chip 17 of the electrode plate 10E.172 Electrical connection.

[0105] The tumor electric field therapy system formed by the electrode 10E, the adapter 20, and the electric field generator 30 operates in the same way as the aforementioned tumor electric field therapy system 100. After the electric field generator 30 controls the adapter 20 and the handshake chip 17 of the electrode 10E to complete the handshake communication and confirm that the electrode 10E is connected normally, when all grounding switches 25 are open and the input terminals 2 and sampling terminals 1 of all bidirectional switching switches 26 are open, all dual-purpose signal lines 19 and AC signal lines 28 are connected, and all electrode units 12 can be given AC signals; when the sampling terminals 1 and input terminals 2 of all bidirectional switching switches 26 are open, the temperature detection signals of the temperature sensors 14 of each electrode unit 12 in each row group can be obtained sequentially by turning on each grounding switch 25 in sequence. Among them, no operation is required for the grounding switches 25 that are in the idle and open state.

[0106] Referring to FIG8, the electrode sheet 10F of the fourth embodiment has 13 electrode units 12, just like the electrode sheet 10D of the third embodiment. However, the specific circuit layout is different. The flexible circuit board 11F of the electrode sheet 10F arranges these 13 electrode units 12 in four rows and four columns on the circuit, with three rows each having 4 electrode units 12 and the remaining row having 1 electrode unit 12. The electrode sheet 10F includes 4 ground lines 18, 4 dual-purpose signal lines 19, 1 ground trace 171 that is connected to the ground pin of the handshake chip 17 and any ground line 28 at the same time, and 1 communication line 172 that is connected to the communication pin of the handshake chip 17. Each grounding wire 18 is used to ground the grounding terminal 14-1 of the temperature sensor 14 of each electrode unit 12 in the corresponding row group. Each dual-purpose signal line 19 is used to short-circuit the dielectric element 15 of each electrode unit 12 in each column group and the signal terminal 14-2 of each temperature sensor 14, for receiving temperature detection signals or transmitting AC signals. A specification page 24 / 34 27 CN 120983810 A connected to the grounding trace 171 also grounds the grounding pin of the handshake chip 17.

[0107] The four grounding wires 18 of the electrode sheet 10F include the first grounding wire 18-1, the second grounding wire 18-2, the third grounding wire 18-3 and the fourth grounding wire 18-4. The first row group includes electrode units 12-1 to 12-4, the second row group includes electrode units 12-5 to 12-8, the third row group includes electrode units 12-9 to 12-12, and the fourth row group includes electrode unit 12-13. Specifically, the first grounding wire 18-1 is used to ground the grounding terminals 14-1 of the temperature sensors 14 of each of the electrode units 12-1 to 12-4 in the first row group; the second grounding wire 18-2 is used to ground the electrode units 12-5 in the second row group.The grounding terminals 14-1 of the temperature sensors 14 of each electrode unit 12-8 are all grounded. The third grounding line 18-3 is used to ground the grounding terminals 14-1 of the temperature sensors 14 of each electrode unit 12-9 to electrode unit 12-12 in the third row group. The fourth grounding line 18-4 is used to ground the grounding terminals 14-1 of the temperature sensors 14 of each electrode unit 12-13 in the fourth row group. The fourth grounding line 18-4 is also connected to the grounding trace 171 connected to the grounding pin of the handshake chip 17. In short, each grounding line 18 shorts and grounds the grounding terminals 14-1 of the temperature sensors 14 of all electrode units 12 in each row group, and one of the grounding lines 18 also shorts and grounds the grounding pin of the handshake chip 17.

[0108] The four dual-purpose signal lines 19 of the electrode sheet 10F include the first dual-purpose signal line 19-1, the second dual-purpose signal line 19-2, the third dual-purpose signal line 19-3 and the fourth dual-purpose signal line 19-4. One end of the first dual-purpose signal line 19-1 is simultaneously connected to the dielectric element 15 of each of the four electrode units 12 (electrode units 12-1, 12-5, 12-9, and 12-13) and the signal terminal 14-2 of each of their respective temperature sensors 14; one end of the second dual-purpose signal line 19-2 is simultaneously connected to the dielectric element 15 of each of the three electrode units 12 (electrode units 12-2, 12-6, and 12-10) and the signal terminal 14-2 of each of their respective temperature sensors 14; one end of the third dual-purpose signal line 19-3 is simultaneously connected to the dielectric element 15 of each of the three electrode units 12 (electrode units 12-3, 12-7, and 12-11) and the signal terminal 14-2 of each of their respective temperature sensors 14; one end of the fourth dual-purpose signal line 19-4 is simultaneously connected to the dielectric element 15 of each of the three electrode units 12 (electrode units 12-4, 12-8, and 12-12) and the signal terminal 14-2 of each of their respective temperature sensors 14. In short, each dual-purpose signal line 19 shorts in parallel the signal terminals 14-2 of the dielectric elements 15 and temperature sensors 14 of each electrode unit 12 located in the same column group and connects them to the adapter 20.

[0109] The first grounding switch 25-1, the second grounding switch 25-2, the third grounding switch 25-3 and the fourth grounding switch 25-4 on the adapter 20 are electrically connected to the first grounding wire 18-1, the second grounding wire 18-2, the third grounding wire 18-3 and the fourth grounding wire 18-4 of the electrode plate 10F respectively through the first connector 40F. The first bidirectional switching switch 26-1, the second bidirectional switching switch 26-2, the third bidirectional switching switch 26-3 and the fourth bidirectional switching switch 26-4 on the adapter 20 are connected to the first bidirectional switching switch 26-1, the second bidirectional switching switch 26-2, the third bidirectional switching switch 26-3 and the fourth bidirectional switching switch 26-4 through the first connector 40F.Connector 40F is electrically connected to the first dual-purpose signal line 19-1, the second dual-purpose signal line 19-2, the third dual-purpose signal line 19-3, and the fourth dual-purpose signal line 19-4, respectively. The fifth bidirectional switch 26-5 is in an idle and disconnected state. A communication transmission line 211 on the adapter 20 is electrically connected to communication line 172, which is connected to the communication pin of the handshake chip 17 on the electrode plate 10F.

[0110] The tumor electric field therapy system formed by the electrode 10F, the adapter 20, and the electric field generator 30 operates in the same way as the aforementioned tumor electric field therapy system 100. After the handshake communication is completed with the first controller 22 of the adapter 20 through the handshake chip 17 and the connection of the electrode 10F is confirmed to be normal, when all grounding switches 25 are all open and the input terminals 2 of all bidirectional switching switches 26 are on, all dual-purpose signal lines 19 and AC signal lines 28 are on, and all electrode units 12 are connected to AC signals. When the sampling terminals 1 of all bidirectional switching switches 26 are on, the temperature detection signals of the temperature sensors 14 of each electrode unit 12 in each row group can be obtained sequentially by turning on each grounding switch 25 in sequence. Among them, no operation is required for the idle grounding switches 25 and / or the idle bidirectional switching switches 26.

[0111] Referring to FIG9, it is a schematic diagram of the circuit connection between the electrode and the adapter 20 in another embodiment of the tumor electric field therapy system of this application. Regarding electrical connections, the difference between the electrode sheet 10H in this embodiment and the aforementioned electrode sheet is also mentioned on pages 25 / 34 of the specification (CN 120983810 A): the number of electrode units 12 and their arrangement in the circuit connection. In this embodiment, the electrode sheet 10H has 9 electrode units 12. The flexible circuit board 11H of the electrode sheet 10H arranges these 9 electrode units 12 in two rows and five columns in the circuit connection, with one row having 5 electrode units 12 and the other row having 4 electrode units 12. The flexible circuit board 11H of the electrode sheet 10H embeds 2 grounding lines 18, 5 dual-purpose signal lines 19, 1 grounding trace 171 connected to the ground pin of the handshake chip 17 and any of the grounding lines 28 simultaneously, and 1 communication line 172 connected to the communication pin of the handshake chip 17. Each grounding wire 18 is used to ground the grounding terminal 14-1 of the temperature sensor 14 of each electrode unit 12 in the corresponding row group. One grounding wire 18 is also used to ground the grounding pin of the handshake chip 17. Each dual-purpose signal line 19 is short-circuited to the dielectric element 15 of each electrode unit 12 in each column group and the signal terminal 14-2 of each temperature sensor 14, for receiving temperature detection signals or transmitting AC signals.

[0112] The two grounding wires 18 of the electrode sheet 10H are the first grounding wire 18-1 and the second grounding wire 18-2. On the electrode sheetIn the two rows of 10H, the first row includes electrode units 12-1 to 12-5, and the second row includes electrode units 12-6 to 12-9. Specifically, the first grounding line 18-1 is used to ground the grounding terminals 14-1 of the temperature sensors 14 of each electrode unit 12-1 to 12-5 in the first row; the second grounding line 18-2 is used to ground the grounding terminals 14-1 of the temperature sensors 14 of each electrode unit 12-6 to 12-9 in the second row, and simultaneously grounds the grounding pin of the handshake chip 17 through the grounding trace 171 connected to the grounding pin of the handshake chip 17. In short, each grounding line 18 short-circuits and grounds the grounding terminals 14-1 of the temperature sensors 14 of all electrode units 12 in each row, and one of the grounding lines 18 also grounds the grounding pin of the handshake chip 17.

[0113] The five dual-purpose signal lines 19 of the electrode sheet 10H include the first dual-purpose signal line 19-1, the second dual-purpose signal line 19-2, the third dual-purpose signal line 19-3, the fourth dual-purpose signal line 19-4 and the fifth dual-purpose signal line 19-5. One end of the first dual-purpose signal line 19-1 is simultaneously connected to the dielectric element 15 of each of the two electrode units 12 (electrode unit 12-1 and electrode unit 12-6) and the signal terminal 14-2 of each of their respective temperature sensors 14; one end of the second dual-purpose signal line 19-2 is simultaneously connected to the dielectric element 15 of each of the two electrode units 12-2 and electrode unit 12-7 and the signal terminal 14-2 of each of their respective temperature sensors 14; one end of the third dual-purpose signal line 19-3 is simultaneously connected to the dielectric element 15 of each of the two electrode units 12-3 and electrode unit 12-8 and the signal terminal 14-2 of each of their respective temperature sensors 14; one end of the fourth dual-purpose signal line 19-4 is simultaneously connected to the dielectric element 15 of each of the two electrode units 12-4 and electrode unit 12-9 and the signal terminal 14-2 of each of their respective temperature sensors 14; one end of the fifth dual-purpose signal line 19-5 is connected to the dielectric element 15 of the electrode unit 12-5 and the signal terminal 14-2 of the temperature sensor 14. In short, each dual-purpose signal line 19 shorts in parallel the signal terminals 14-2 of the dielectric elements 15 and temperature sensors 14 of each electrode unit 12 located in a corresponding column group and connects them to the adapter 20.

[0114] The first grounding switch 25-1 and the second grounding switch 25-2 on the adapter 20 are electrically connected to the first grounding wire 18-1 and the second grounding wire 18-2 of the electrode plate 10H respectively through the first connector 40H. The third grounding switch 25-3 and the fourth grounding switch 25-4 are in an idle and open state. The first bidirectional switching switch 26-1 and the second bidirectional switching switch 26-1 on the adapter 20 are also connected to the first grounding wire 18-1 and the second grounding wire 18-2 of the electrode plate 10H respectively.Switches 26-2, 26-3, 26-4, and 26-5 are electrically connected to the first dual-purpose signal line 19-1, 19-2, 19-3, 19-4, and 19-5 respectively via the first connector 40H. A communication transmission line 211 on the adapter 20 is electrically connected to the communication line 172, which is connected to the communication pin of the handshake chip 17 on the electrode plate 10H.

[0115] The tumor electric field therapy system formed by the electrode 10H, the adapter 20, and the electric field generator 30 operates in the same way as the aforementioned tumor electric field therapy system 100. After the electric field generator 30 controls the adapter 20 and the handshake chip 17 of the electrode 10E to complete the handshake communication and confirm that the electrode 10E is connected normally, when all grounding switches 25 are open and the input terminal 2 of all bidirectional switching switches 26 (page 26 / 34, CN 120983810 A 26) is on and the sampling terminal 1 is off, all dual-purpose signal lines 19 and AC signal lines 28 are on, and all electrode units 12 are connected to AC signals. When the sampling terminal 1 of all bidirectional switching switches 26 is on and the input terminal 2 is off, the temperature detection signals of the temperature sensors 14 of each electrode unit 12 in each row group can be obtained sequentially by turning on each grounding switch 25. Among them, no operation is required for the grounding switches 25 that are in the idle and open state.

[0116] In the preceding embodiments, the number of grounding switches 25 corresponding to each electrode piece 10, 10D, 10E, 10F, and 10H of the adapter 20 is fixed at 4, and the number of bidirectional switching switches 26 corresponding to each electrode piece 10, 10D, 10E, 10F, and 10H is fixed at 5. This allows for the application of various electrode pieces 10, 10D, 10E, 10F, and 10H with different numbers of electrode units 12. However, in some cases, grounding switches 25 and / or bidirectional switching switches 26 may be in an idle or disconnected state, which can complicate the program control. To simplify the control program, specific adapters can be provided corresponding to the number of grounding wires 18 and the number of dual-purpose signal lines 19 of the electrode pieces to avoid the occurrence of grounding switches 25 and / or bidirectional switching switches 26 in an idle or disconnected state, thus facilitating program control. That is, in other embodiments, the number of grounding switches 25 in each group of grounding switches 25 provided on the adapter 20 can be set according to the number of rows of each electrode unit 12 of the corresponding electrode sheet in the circuit connection, or according to the number of grounding wires 18 on the flexible circuit board of the corresponding electrode sheet; the number of bidirectional switching switches 26 in each group of bidirectional switching switches 26 provided on the adapter 20 can be set according to the number of columns of each electrode unit 12 of the corresponding electrode sheet in the circuit connection, or according to the number of dual-purpose signal lines 19 on the flexible circuit board of the corresponding electrode sheet.Quantity setting. Preferably, the number of ground switches 25 in each group of ground switches 25 of the adapter 20 is equal to the number of rows of each electrode unit 12 of the corresponding electrode sheet in the circuit connection, or equal to the number of ground wires 18 on the flexible circuit board of the corresponding electrode sheet; the number of bidirectional switching switches 26 in each group of bidirectional switching switches 26 set on the adapter 20 is equal to the number of columns of each electrode unit 12 of the corresponding electrode sheet in the circuit connection, or equal to the number of dual-purpose signal lines 19 on the flexible circuit board of the corresponding electrode sheet

[0117] The present invention also provides a temperature detection method for electrode sheet 10 in tumor electric field therapy system 100. Referring to FIG10, the method includes:

[0118] Step S10: performing handshake communication with the handshake chip 17 of the electrode sheet 10 through the adapter 20 to determine the connection status of the corresponding electrode sheet 10.

[0119] Step S20: When the electrode 10 and the adapter 20 are normally connected, the adapter 20 is used to configure the switching states of each grounding switch 25 and each bidirectional switching switch 26 corresponding to the electrode 10, so that the temperature signals detected by each temperature sensor 14 in each row group are sampled sequentially through the corresponding temperature sampling points.

[0120] The present invention also provides an electrode type identification method. The electrode type identification is performed when all temperature sensors of the electrode are normally connected. In addition to the above steps S10 and S20, the method also includes:

[0121] Step S30: Identify the type of the corresponding electrode 10 according to the temperature signals detected by all temperature sensors 14 of the corresponding electrode 10.

[0122] The temperature signals detected by all temperature sensors 14 of the corresponding electrode 10 sampled in step S30 are temperature analog signals. Step S30 specifically includes the following steps:

[0123] Step S301: Perform digital-to-analog conversion on all sampled temperature analog signals to obtain several AD sampling values;

[0124] Step S302: Determine the number of electrode units 12 of the corresponding electrode sheet 10 according to the several AD sampling values;

[0125] Step S303: Determine the type of the corresponding electrode sheet 10 according to the number of electrode units 12.

[0126] The present invention also provides a method for judging abnormal electrode sheet temperature. The judgment of abnormal electrode sheet temperature is performed during tumor electric field therapy by applying alternating current signals to each electrode unit of the electrode sheet. In addition to the above steps S10 and S20, the method also includes the following steps: Specification 27 / 34 Page 30 CN 120983810 A

[0127] Step S40: Judge whether the corresponding electrode sheet 10 has a temperature abnormality based on the temperature signals detected by all temperature sensors of the sampled corresponding electrode sheet.

[0128] Step S40 specifically includes the following steps:

[0129] Step S401: Compare all sampled temperature signals with a preset temperature threshold;

[0130] Step S402: Determine whether there is a temperature abnormality in the electrode plate based on the comparison results.

[0131] The comparison results in step S402 include temperature signals less than the preset temperature threshold and temperature signals greater than or equal to the preset temperature threshold. The determination of temperature abnormality is as follows: when there is a temperature signal greater than or equal to the preset temperature threshold among all sampled temperature signals, the electrode plate temperature is determined to be abnormal; when all sampled temperature signals are less than the preset temperature threshold, the electrode plate temperature is determined to be normal. The preset temperature threshold is 39℃-44℃, preferably 41℃.

[0132] The present invention also includes an alternating electrical signal adjustment method, which, in addition to steps S10 and S20, also includes: adjusting the alternating electrical signal applied to the corresponding electrode plate according to the temperature signals detected by all temperature sensors of the corresponding electrode plate. The adjustment is to adjust the magnitude of the voltage, current or power of the alternating electrical signal.

[0133] Referring to FIG11, the present invention also provides an electric field control method applied to the tumor electric field therapy system 100, the electric field control method comprising the following steps:

[0134] In step 101, the tumor electric field therapy system 100 is connected.

[0135] Specifically, four electrode plates 10 are respectively connected to an adapter 20, the adapter 20 is connected to an electric field generator 30, and the electric field generator 30 is connected to a suitable power supply.

[0136] In step 102, it is detected whether the user issues a command to turn on the electric field. If no command to turn on the electric field is detected, step 102 is repeated; if a command to turn on the electric field is detected, step 103 is performed.

[0137] In step 103, after the electric field generator 30 of the tumor electric field therapy system 100 sends a handshake signal to the electrode 10 connected to the X1 port through the second connector 50, the adapter 20, and the first connector 40 connected to the X1 port, the first controller 22 of the adapter 20 receives the feedback signal from the electrode 10 at the X1 port through the corresponding communication transmission line 211 and determines whether the handshake is successful; if it fails, proceed to step 105; if it succeeds, proceed to step 106.

[0138] This determination step can occur in the adapter 20 or the electric field generator 30. In this embodiment, the determination step occurs in the adapter 20. Specifically, when the electrode 10 at the X1 port is connected normally, its handshake chip 17 can receive the handshake request signal from the electric field generator 30 and feed back the handshake status to the first controller 22 of the adapter 20. The first controller 22 determines that the handshake is successful. Conversely, if the electrode plate 10 at the X1 port is abnormally connected, the first controller 22 of the adapter 20 will not receive a feedback signal from its handshake chip 17, and the first controller 22 will determine that the handshake has failed.

[0139] In step 105, the tumor electric field therapy system 100 issues an alarm due to handshake failure, and then proceeds to step 101.

[0140] In step 106, after the electric field generator 30 sends a handshake signal to the electrode 10 connected to the X2 port through the second connector 50, the adapter 20, and the first connector 40 connected to the X2 port, the first controller 22 on the adapter 20 receives the feedback signal from the electrode 10 at the X2 port through the corresponding communication transmission line 211, and determines whether the handshake is successful. If it fails, proceed to step 105; if it succeeds, proceed to step 107.

[0141] This determination step can occur in the adapter 20 or the electric field generator 30. In this embodiment, the determination step occurs in the adapter 20. Specifically, when the electrode 10 at the X2 port is connected normally, its handshake chip 17 can receive the handshake request signal from the electric field generator 30 and feed back the handshake status to the first controller 22 of the adapter 20. The first controller 22 determines that the handshake is successful. Conversely, if the electrode 10 at the X2 port is abnormally connected, the first controller 22 of the adapter 20 will not receive the feedback signal from its handshake chip 17, and the first controller 22 will determine that the handshake has failed.

[0142] In step 107, after the electric field generator 30 sends a handshake signal to the electrode 10 connected to the Y1 port through the second connector 50, the adapter 20, and the first connector 40 connected to the Y1 port, the first controller 22 on the adapter 20 receives the feedback signal from the electrode 10 at the Y1 port through the corresponding communication transmission line 211, and determines whether the handshake has passed. If it has failed, proceed to step 105; if it has passed, proceed to step 108.

[0143] This determination step can occur in the adapter 20 or the electric field generator 30. In this embodiment, the determination step occurs in the adapter 20. Specifically, when the electrode 10 at the Y1 port is properly connected, its handshake chip 17 can receive the handshake request signal from the electric field generator 30 and feed back the handshake status to the first controller 22 of the adapter 20. The first controller 22 determines that the handshake is successful. Conversely, when the electrode 10 at the Y1 port is improperly connected, the first controller 22 of the adapter 20 does not receive the feedback signal from its handshake chip 17, and the first controller 22 determines that the handshake has failed.

[0144] In step 108, after the electric field generator 30 sends a handshake signal to the electrode 10 connected to the Y2 port through the second connector 50, the adapter 20, and the first connector 40 connected to the Y2 port, the first controller 22 on the adapter 20 receives the feedback signal from the electrode 10 at the Y2 port through the corresponding communication transmission line 211, and determines whether the handshake is successful. If it fails, proceed to step 105; if it succeeds, proceed to step 109.

[0145] This judgment step can occur in the adapter 20 or the electric field generator 30; in this embodiment, it occurs in the adapter 20. Specifically, when the electrode 10 at the Y1 port is properly connected, its handshake chip 17 can receive the handshake request signal from the electric field generator 30 and feed back the handshake status to the first controller 22 of the adapter 20. The first controller 22 then determines that the handshake is successful. Conversely, when the electrode 10 at the Y2 port is improperly connected, the first controller 22 of the adapter 20 does not receive the feedback signal from its handshake chip 17, and therefore determines that the handshake has failed.

[0146] In steps 103, 106, 107, and 108 above, after receiving the handshake signal from the tumor electric field therapy system 100, the adapter 20 needs to control the corresponding grounding switch 25 and bidirectional switching switch 26 through the first controller 22, so that the grounding switch 25, which is only electrically connected to the handshake chip 17, is closed, and all other grounding switches 24 are opened, and the sampling terminals 1 and input terminals 2 of the corresponding bidirectional switching switches 26 are all turned on and all are turned off, so that the handshake chip 17 is electrically connected to the grounding pin GND of the adapter 20 through the first connector 40, so that the handshake chip 17 can work normally. If the electric field generator 30 and the adapter 20, the adapter 20 and the adapter 20, and the adapter 20 and the electrode 10 are all normally connected, then the handshake signal issued by the electric field generator 30 can finally reach the handshake chip 17 of the electrode 10, and the handshake status of the handshake chip 17 can be fed back to the electric field generator 30. If at least one connection abnormality occurs between the electric field generator 30 and the adapter 20, between the adapters 20 and each other, or between the adapter 20 and the electrode 10, the handshake chip 17 will fail to connect VCC and GND to form a circuit, resulting in the adapter 20 and the electric field generator 30 receiving an empty handshake status signal, thus the handshake will fail.

[0147] In step 109, the electric field generator 30 of the tumor electric field therapy system 100 sets the electric field parameters and then proceeds to step 110. The electric field parameters include the frequency, voltage, current, or power amplitude of the alternating electric signal, etc.

[0148] In step 110, the adapter 20 sends a temperature reading request to the first connector 40 at the Y1 port and the first connector 40 at the Y2 port to collect the temperature detection signals corresponding to the 40 temperature sensors 14 on the electrode 10 at the Y1 port and the electrode 10 at the Y2 port, and then proceeds to step 111.

[0149] In step 111, the tumor electric field therapy system 100 determines the type of the electrode pad 10 at port Y1 and port Y2 by collecting the temperature signals, and then proceeds to step 112.

[0150] Specifically, determining the type of the electrode pad 10 at port Y1 and port Y2 is based on the number of temperature detection signals of the electrode pad 10 at port Y1 and the number of temperature detection signals of the electrode pad 10 at port Y2.The number of temperature sensors 14 for each electrode 10 at port Y1 and port Y2 is determined. This determination process can occur in adapter 20 or electric field generator 30. In this embodiment, electrode 10 has 20 temperature sensors 14, so there are a total of 40 effective temperature signals. Specification 29 / 34 pages 32 CN 120983810 A

[0151] In step 112, the tumor electric field therapy system 100 determines whether the temperature signal collected by adapter 20 is abnormal. If it is abnormal, it proceeds to step 114. If all temperature signals are normal, it proceeds to step 113.

[0152] In step 113, electric field generator 30 applies an alternating current signal to a pair of electrode 10 connected to ports Y1 and Y2, and at the same time stops applying an alternating current signal to a pair of electrode 10 connected to ports X1 and X2 and proceeds to step 115.

[0153] In step 114, the tumor electric field therapy system 100 alarms due to abnormal temperature signals from the electrode 10 connected to the Y1 port or the electrode 10 connected to the Y2 port, and then immediately proceeds to step 120.

[0154] In step 115, the adapter 20 sends temperature reading requests to the first connector 40 of the X1 port and the first connector 40 of the X2 port respectively to collect the temperature signals corresponding to all temperature sensors 14 on the electrode 10 at the X1 port and the electrode 10 at the X2 port, and then proceeds to step 116.

[0155] In step 116, the tumor electric field therapy system 100 determines the type of the electrode 10 at the X1 port and the electrode 10 at the X2 port based on the temperature signals and then proceeds to step 117.

[0156] The type of the electrode 10 at the X1 port and the electrode 10 at the X2 port is determined by determining the number of temperature sensors 14 connected to the electrode 10 at the X1 port and the electrode 10 at the X2 port. This judgment process can occur in the adapter 20 or the electric field generator 30. In this embodiment, the electrode 10 has 20 temperature sensors 14, so there are a total of 40 valid temperature signals.

[0157] In step 117, the tumor electric field therapy system 100 judges whether the temperature signal collected by the adapter 20 is abnormal. If it is abnormal, it proceeds to step 114. If all 40 valid temperature signals are normal, it proceeds to step 118.

[0158] In step 118, the electric field generator 30 applies an alternating electrical signal to a pair of electrode 10 connected to ports X1 and X2, and at the same time stops applying the alternating electrical signal to a pair of electrode 10 connected to ports Y1 and Y2 and proceeds to step 119. The total time for steps 113, 115, 116, 117 to 118 is fixed at 1 second.

[0159] In step 119, the tumor electric field therapy system 100 executes subsequent steps based on whether a user has issued a command to shut down the electric field. If a command to shut down the electric field is detected, it proceeds to step 120; otherwise, it proceeds to step 121.

[0160] In step 120, after shutting down the electric field, the tumor electric field therapy system 100 proceeds to step 101. At this time, the electric field therapy ends and waits for the next command to turn the electric field back on.

[0161] In step 121, the tumor electric field therapy system 100 determines whether the electric field parameters need to be adjusted based on the current electric field amplitude and the collected temperature signal. If the electric field parameters need to be adjusted, it proceeds to step 109; otherwise, it proceeds to steps 110 to 119 in a loop. The total time for steps 118, 119, 121, 110, 111, 112, and 113 is fixed at 1 second in this embodiment. Thus, the tumor electric field therapy system 100 can continuously output alternating electrical signals with a 2-second cycle, alternating between applying an alternating electrical signal in the first direction between a pair of electrodes 10 connected to ports X1 and X2 and an alternating electrical signal in the second direction between another pair of electrode plates 10 connected to ports Y1 and Y2. Simultaneously, the tumor electric field therapy system 100 can reduce the time interval between turning off the alternating electrical signal applied to the pair of electrode plates 10 connected to ports X1 and X2 and turning on the alternating electrical signal applied to the other pair of electrode plates 10 connected to ports Y1 and Y2 to 0 seconds; and reduce the time interval between turning off the alternating electrical signal applied to the other pair of electrode plates 10 connected to ports Y1 and Y2 and turning on the alternating electrical signal applied to the pair of electrode plates 10 connected to ports X1 and X2 to 0 seconds, thereby extending the electric field therapy time while ensuring accurate temperature acquisition.

[0162] This application also provides some temperature detection methods and AC signal application control methods, which are described below using electrode 10 as an example.

[0163] This application provides an electrode temperature detection method, which is applied to the electrode 10 or the tumor electric field treatment system 100 as described above, as shown in Figure 12. It includes the following steps:

[0164] Step 210: Under the condition that the electrode is normally connected by the handshake chip, control each bidirectional switching switch 26 electrically connected to each electrode unit 12 of the electrode 10 to disconnect the AC signal applied to the dielectric element 15 of each electrode unit 12 of the electrode 10, and at the same time connect the DC signal applied to the signal terminal 14-2 of the temperature sensor 14 of each electrode unit 12 of the electrode 10;

[0165] Step 220: Sequentially connect the ground terminal of the temperature sensor 14 of each row group electrode unit 12 of the electrode 10.14-1 corresponds to the grounding switch 25 electrically connected to obtain the temperature detection signal of the temperature sensor 14 of each electrode unit 12 of the electrode sheet 10.

[0166] Step 210 specifically involves: controlling the bidirectional switching switch 26 electrically connected to each electrode unit 12 of the electrode sheet 10 to switch from the end electrically connected to the AC signal to the end electrically connected to the DC signal, that is, controlling the bidirectional switching switch 26 electrically connected to the electrode sheet 10 to switch from its input terminal 2 to its sampling terminal 1; or

[0167] controlling the bidirectional switching switch 26 electrically connected to each electrode unit 12 of the electrode sheet 10 to switch the dielectric element 15 of each electrode unit 12 of the electrode sheet 10 from the on state to the off state, and at the same time switching the signal terminal 14-2 of the temperature sensor 14 of each electrode unit 12 of the electrode sheet 10 from the off state to the on state.

[0168] The electrode sheet temperature detection method of this application can quickly and accurately obtain the temperature detection signals of all electrode units of the electrode sheet; and can determine whether the temperature sensors of the electrode sheet are faulty, abnormal, or whether the electrode sheet is qualified and needs to be replaced based on the obtained temperature detection signals of all temperature sensors of the electrode sheet; can also determine whether each electrode unit of the electrode sheet is overheated based on the obtained temperature detection signals of all temperature sensors of the electrode sheet when all temperature sensors of the electrode sheet are normal, and then control the AC signal applied to the electrode sheet or applied to each electrode unit of the electrode sheet; can also identify the electrode sheet type when the temperature detection signals of each temperature sensor of the electrode sheet are normal.

[0169] Referring to Figure 13, this application embodiment also provides a method for controlling the application of alternating current signals for tumor electric field therapy, which includes the above-mentioned steps 210 and 220, and after step 220, it further includes:

[0170] Step 260: When it is determined that the electrode sheet 10 does not need to be replaced, the alternating current signals applied to each electrode unit 12 of the electrode sheet 10 are controlled or adjusted according to the temperature detection signals of the temperature sensors 14 of each electrode unit 12 of the electrode sheet 10.

[0171] Step 260 further includes controlling or adjusting the AC signal applied to each electrode unit 12 of the electrode sheet 10:

[0172] Step 261: When the temperature detection signals of each electrode unit 12 of the electrode sheet 10 are not exceeded by a preset temperature threshold, continue to apply AC signals to each electrode unit 12 of the electrode sheet 10; or

[0173] Step 262: When there is a temperature detection signal in all the temperature detection signals of the electrode units 12 of the electrode sheet 10 that exceeds the preset temperature threshold, stop applying AC signals to the electrode units 12 of the electrode sheet 10.

[0174] The step of stopping applying AC signals to the electrode units 12 of the electrode sheet 10 in step 262 includes stopping applying AC signals to all the electrode units 12 of the electrode sheet 10 and stopping applying AC signals to the electrode sheet 10 when the temperature detection signal exceeds the preset temperature threshold.When AC signals are applied to the electrode unit 12 with a temperature detection signal exceeding a preset temperature threshold, AC signals are stopped being applied to all electrode units 12 in the column where the temperature detection signal exceeds a preset temperature threshold.

[0175] When AC signals are stopped being applied to the electrode unit 12 in the column where the temperature detection signal exceeds a preset temperature threshold, AC signals are still applied to the electrode units 12 in the column where the temperature detection signal does not exceed the preset temperature threshold.

[0176] When AC signals are stopped being applied to all electrode units 12 in the column where the temperature detection signal exceeds a preset temperature threshold, AC signals are still applied to all electrode units 12 in the column where the temperature detection signal does not exceed the preset temperature threshold and are in a different column from the electrode units 12 where the temperature detection signal exceeds the preset temperature threshold.

[0177] The process of continuing to apply an AC signal to the electrode plate 10 in step 261 is as follows:

[0178] Step 263: When the temperature detection signal is much lower than the preset temperature threshold, continue to apply an AC signal to each electrode unit 12 of the electrode plate 10 by increasing the voltage or current amplitude of the AC signal applied to each electrode unit 12 of the electrode plate 10, or continue to apply an AC signal to each electrode unit 12 of the electrode plate 10 by keeping the voltage or current amplitude of the AC signal applied to each electrode unit 12 of the electrode plate 10 unchanged; or

[0179] Step 264: When the temperature detection signal is close to the preset temperature threshold, continue to apply an AC signal to each electrode unit 12 of the electrode plate 10 by keeping the voltage or current amplitude of the AC signal applied to each electrode unit 12 of the electrode plate 10 unchanged, or continue to apply an AC signal to each electrode unit 12 of the electrode plate 10 by decreasing the voltage or current amplitude of the AC signal applied to each electrode unit 12 of the electrode plate 10.

[0180] Referring to FIG14, this application also provides a signal control method for tumor electric field therapy, used for the above-mentioned electrode sheet 10. The method includes:

[0181] Step 310: Combining control of a set of grounding switches 25 and a set of bidirectional switching switches 26 electrically connected to the corresponding electrode sheet 10 to apply AC signals to each electrode unit 12 of the electrode sheet 10 and executing step 320;

[0182] Step 320: Combining control of a set of grounding switches 25 and a set of bidirectional switching switches 26 electrically connected to the electrode sheet 10 to collect temperature detection signals of each electrode unit of the electrode sheet 10 in a row and executing step 330;

[0183] Step 330: Determining the combination control mode of the set of grounding switches 25 and the set of bidirectional switching switches 26 electrically connected to the electrode sheet 10 according to the collected temperature detection signals and executing step 340;

[0184] Step 340: Control the working state of each electrode unit 12 of the electrode sheet 10 according to the determined combination control method of grounding switch 25 and bidirectional switching switch 26.

[0185] The working state of each electrode unit 12 of the electrode sheet 10 mentioned in step 340 includes one of the following: stopping the application of AC signal and continuing to collect temperature detection signal, and stopping the collection of temperature detection signal and continuing to apply AC signal. Continuing to apply AC signal includes continuing to apply AC signal by increasing the voltage or current amplitude of the currently applied AC signal, continuing to apply AC signal by keeping the voltage or current amplitude of the currently applied AC signal unchanged, and continuing to apply AC signal by decreasing the voltage or current amplitude of the currently applied AC signal.

[0186] The working state of each electrode unit 12 of the electrode sheet 10 is determined by the temperature detection signal it collects. Each electrode unit 12 of the electrode sheet 10 is divided into different regions, and each electrode unit 12 in each region can be cyclically switched between applying AC signal and collecting temperature detection signal by the combination control of grounding switch 25 and bidirectional switching switch 26.

[0187] This application embodiment provides another method for detecting the temperature of an electrode sheet in a tumor electric field therapy system. Referring to FIG15, taking electrode sheet 10 as an example, the temperature detection method includes:

[0188] Step 510: Disconnect the input of AC power signal to electrode sheet 10, perform combined control of multiple grounding switches 25 and multiple bidirectional switching switches 26, and acquire the temperature detection signal of temperature sensor 14 of electrode sheet 10 corresponding to each combination;

[0189] Step 520: Sample and convert the temperature detection signal detected by each temperature sensor 14 in electrode sheet 10 to obtain a digital temperature signal;

[0190] Step 530: Transmit the digital temperature signal to the electric field generator 30 of tumor electric field therapy system 100 so that the electric field generator 30 can determine the temperature at the corresponding electrode unit 12 according to the digital temperature signal. Instruction manual, pages 32 / 34, CN 120983810 A

[0191] In step 510, “combined control of multiple grounding switches 25 and multiple bidirectional switching switches 26” specifically includes:

[0192] Step 511: all bidirectional switching switches 26 are placed at sampling end 1 to conduct the electrical connection between the signal terminals 14-2 of each temperature sensor 14 of all electrode units 12 and the corresponding analog-to-digital converter 23;

[0193] Step 512: one of the multiple grounding switches 25 is closed sequentially and time-divisionally to collect the temperature detection signal detected by the temperature sensor 14 of each electrode unit 12 in the corresponding row group.

[0194] In step 512, closing one of the multiple grounding switches 25 sequentially and time-divisionally can make the detection channel of the analog-to-digital converter 23 electrically connected to each temperature sensor 14 in the row group corresponding to the closed grounding switch 25 conduct.

[0195] Thus, the temperature detection signals of each temperature sensor 14 in each row group can be obtained sequentially, and then processed by the adapter 20 or the electric field generator 30 to obtain the temperature corresponding to all electrode units 12 on the electrode sheet 10; thereby making the temperature detection of the patient's body surface more comprehensive and accurate.

[0196] For the tumor electric field therapy system 100 of this application embodiment, temperature detection can also be performed on individual electrode units 12 as needed. The specific process of temperature detection for a certain electrode unit 12 of the electrode sheet 10 is as follows: disconnect the input of the AC signal, place the bidirectional switching switch 26 corresponding to the column group where the electrode unit 12 that needs to be measured individually is located at the sampling end 1, and place the remaining bidirectional switching switches 26 at the input end 2; at the same time, turn on and ground the grounding switch 25 corresponding to the row group where the electrode unit 12 that needs to be measured individually is located, and turn off all the remaining grounding switches 25. Thus, the temperature detection signals of the temperature sensor 14 in the electrode unit 12 that needs to be measured individually can be sampled to obtain the temperature of the electrode unit 12. For example, the electrode unit 12 that needs to be measured separately is electrode unit 12-1. In this case, the first bidirectional switching switch 26-1 corresponding to electrode unit 12-1 is placed at the sampling end 1, and the remaining bidirectional switching switches (second bidirectional switching switch 26-2, second bidirectional switching switch 26-3, third bidirectional switching switch 26-3 and fourth bidirectional switching switch 26-4) are all placed at the input end 2; at the same time, the first grounding switch 25-1 corresponding to electrode unit 12-1 is closed and grounded, and the remaining grounding switches (second grounding switch 25-2, third grounding switch 25-3 and fourth grounding switch 25-4) are all opened. Thus, the temperature of electrode unit 12-1 can be detected.

[0197] This application embodiment also provides another method for applying an alternating current signal for tumor electric field therapy, applied to the above-mentioned tumor electric field therapy system, and the tumor electric field therapy system 100 in FIG1 is used as an example for description. Referring to Figure 16, the AC signal application method includes:

[0198] Step 610: Determine the area where the electrode unit 12 to which the AC signal needs to be applied is located in the electrode plate 10;

[0199] Step 611: Combine and control multiple grounding switches 25 and multiple bidirectional switching switches 26 electrically connected to the electrode plate 10 to apply the AC signal.

[0200] Step 611, "combining and controlling multiple grounding switches 25 and multiple bidirectional switching switches 26 electrically connected to the electrode plate 10", specifically includes:

[0201] Step 612: Disconnect all grounding switches 25 electrically connected to the electrode plate 10;

[0202] Step 613: Determine the column group where the electrode unit 12 to which the AC signal needs to be applied is located, based on the area where the electrode unit 12 to which the AC signal needs to be applied is located;

[0203] Step 614: Determine the bidirectional switching switch 26 electrically connected to the electrode unit 12 in the column group where the electrode unit 12 that needs to be applied AC signal is located;

[0204] In step 610: Divide each of the four adjacent electrode units 12 in the electrode sheet 10 into a region, and the four electrode units 12 in each region correspond to a column group, connected to a dual-purpose signal line 19 corresponding to the same bidirectional switching switch 26. In other embodiments, the electrode units 12 have other division methods, which will not be described here. Specification 33 / 34 pages 36 CN 120983810 A

[0205] Step 615: Control the bidirectional switching switch 26 electrically connected to the electrode unit 12 that needs to be applied AC signal to electrically connect the electrode unit 12 that needs to be applied AC signal to the AC signal line 28 to apply AC signal; at the same time, control the remaining bidirectional switching switches 26 to disconnect the electrical connection between each electrode unit 12 in the region that does not need to be applied AC signal and the AC signal line 28 to stop applying AC signal.

[0206] In step 615, “connecting the electrode unit that needs to be applied with an AC signal to the AC signal line 28 to apply the AC signal and disconnecting the electrical connection between the electrode unit 12 in the area where no AC signal needs to be applied and the AC signal line 28 to stop applying the AC signal” is achieved by placing the bidirectional switching switch 26, which is electrically connected to the electrode unit 12 in the column group corresponding to the area in the electrode sheet 10 where the AC signal needs to be applied, at its input terminal 2, and placing all the bidirectional switching switches 26, which are electrically connected to the electrode unit 12 in the remaining column groups, at the sampling terminal 1.

[0207] When the above methods are applied to electrode plates 10D, 10E, 10F, and 10H in other embodiments, since there are grounding switches 25 and / or bidirectional switching switches 26 in an idle and disconnected state on the adapter 20 that are not electrically connected to the corresponding electrode plates 10D, 10E, 10F, and 10H, the corresponding grounding switches 25 and / or bidirectional switching switches 26 in an idle and disconnected state do not need to be controlled.

[0208] Although the various operations are depicted in the drawings in a specific order, this should not be construed as requiring that these operations must be performed in the specific order shown or in a sequential order, nor should it be construed as requiring that all the operations shown must be performed to obtain the desired result.

[0209] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of this application, and not to limit them; although this application has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some or all of the technical features; and these modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the technology of the embodiments of this application.The scope of the solutions should be covered by the claims and description of this application. In particular, as long as there is no structural conflict, the technical features mentioned in the various embodiments can be combined in any way. This application is not limited to the specific embodiments disclosed herein, but includes all technical solutions falling within the scope of the claims. Instruction manual page 34 / 34, page 37, CN 120983810 A, Figure 1; Instruction manual figure 1 / 13, page 38, CN 120983810 A, Figure 2; Instruction manual figure 2 / 13, page 39, CN 120983810 A, Figure 3; Instruction manual figure 3 / 13, page 40, CN 120983810 A, Figure 4; Instruction manual figure 4 / 13, page 41, CN 120983810 A, Figure 5; Instruction manual figure 5 / 13, page 42, CN 120983810 A, Figure 6; Instruction manual figure 6 / 13, page 43, CN 120983810 A, Figure 7; Instruction manual figure 7 / 13, page 44, CN 120983810 A, Figure 8; Instruction manual figure 8 / 13, page 45, CN 120983810 A, Figure 9; Figure 10; Instruction manual figure 9 / 13, page 46, CN 120983810 A, Figure 11. Figures 10 / 13, page 47, CN 120983810 A, Figures 12 and 13; Figures 11 / 13, page 48, CN 120983810 A, Figures 14 and 15; Figures 12 / 13, page 49, CN 120983810 A, Figure 16; Figures 13 / 13, page 50, CN 120983810 A. Abstract: The present invention provides an adapter and a tumor electric field therapy, the tumor electric field therapy comprising an electrode array, the electrode array is provided with a flexible circuit board, a plurality of electrode units and a handshake chip used for handshake communications, and the electrode unit comprises a...dielectric element and a temperature sensor with a signal end and a grounding end. The flexible circuit board is provided with multiple paths of grounding wires connected to the grounding ends and multiple paths of dual-purpose signal wires connected to the signal ends, and the dielectric element of the electrode unit is in short circuit with the signal end of the electrode unit. The adapter is provided with a plurality of grounding switches and a plurality of bidirectional switching switches, each grounding wire is grounded through a corresponding grounding switch, and each dual-purpose signal wire is electrically connected with a corresponding bidirectional switching switch. The number of the bidirectional switching switches is greater than or equal to the number of the dual-purpose signal wires, and / or the number of the grounding switches is greater than or equal to the number of the grounding wires. The bidirectional switching switch connects the dual-purpose signal wire to an ACsignal wire for transmitting an AC electrical signal or to a detection channel of an analog-to-digital converter for transmitting temperature signals of the temperature sensors. {JSHL-26017-HKSPT / 02490517v1}

Claims

1. An adapter for use in a tumor electric field therapy system including electrode pads, characterized in that, The electrode sheet is provided with a flexible circuit board and a plurality of electrode units arranged on the flexible circuit board, the electrode unit comprises a dielectric element and a temperature sensor with a signal end and a ground end, wherein the dielectric element is short-circuited with the signal end of the temperature sensor; a plurality of electrode units are arranged in multiple rows and multiple columns in the circuit, the flexible circuit board is provided with a plurality of ground lines and a plurality of dual-purpose signal lines, the ground end of each temperature sensor in the same row group is connected to the same ground line, the ground end of each temperature sensor in different row groups is connected in parallel through different ground lines, the signal end of each temperature sensor in the same column group is connected to the same dual-purpose signal line, and the signal end of each temperature sensor in different column groups is connected in parallel through different dual-purpose signal lines; the adapter corresponds to the electrode sheet and is provided with a plurality of ground switches and a plurality of bidirectional switching switches, wherein the number of bidirectional switching switches is greater than or equal to the number of dual-purpose signal lines and / or the number of ground switches is greater than or equal to the number of ground lines, at least part of the ground switches are respectively connected to each ground line of the electrode sheet, at least part of the bidirectional switches are respectively connected to each dual-purpose signal line of the electrode sheet, the bidirectional switching switch has an input end for connecting alternating current signal and a sampling end for connecting direct current signal for temperature collection, and is configured to transmit alternating current signal to the dielectric element of the corresponding electrode unit through the dual-purpose signal line electrically connected thereto when the input end is connected to alternating current signal, or transmit direct current signal to the signal end of the corresponding temperature sensor through the dual-purpose signal line electrically connected thereto when the sampling end is connected to direct current signal; when the input end of at least part of the bidirectional switching switches electrically connected to each dual-purpose signal line is connected to alternating current signal, all the ground switches are disconnected; when the input end of each bidirectional switching switch is disconnected and the sampling end of at least part of the bidirectional switching switches is connected to direct current signal, at least part of the ground switches are turned on one by one.

2. The adapter of claim 1, wherein, The adapter corresponds to the electrode sheet and is provided with five bidirectional switching switches and four ground switches.

3. The adapter of claim 2, wherein, The bidirectional switching switch not connected to the dual-purpose signal line is in an idle and disconnected state.

4. The adapter of claim 2, wherein, The ground switch not connected to the ground line is in an idle and disconnected state.

5. The adapter of claim 1, wherein, The electrode sheet is provided with a handshake chip, the adapter sends a handshake signal to the handshake chip and receives a feedback signal of the handshake chip to determine whether it is normally connected to the electrode sheet, and after being normally connected to the electrode sheet, the adapter makes the electrode sheet connect to alternating current signal for tumor treatment or direct current signal for temperature collection by configuring the state of each ground switch and each bidirectional switching switch.

6. The adapter of claim 5, wherein, The adapter is provided with a first controller, which controls the conduction and disconnection of each ground switch and the conduction of the input end or the sampling end of each switching switch.

7. The adapter of claim 6, wherein, The adapter receives temperature signals detected by the temperature sensors and converts the signals into digital signals.

8. The adapter of claim 7, wherein, The first controller determines whether the electrode sheet has a temperature abnormality based on the digital signals.

9. A tumor electric field treatment system, comprising: It comprises: an electric field generator providing an alternating current signal; an electrode sheet provided with a flexible circuit board and a plurality of electrode units on the flexible circuit board, each electrode unit comprising a dielectric element and a temperature sensor having a signal terminal and a ground terminal, wherein the dielectric element is short-circuited with the signal terminal of the temperature sensor; the electrode units are arranged in multiple rows and columns in an electric circuit, the flexible circuit board is provided with a plurality of ground lines and a plurality of dual-purpose signal lines, the ground terminals of the temperature sensors in the same row group are connected to the same ground line, the ground terminals of the temperature sensors in different row groups are connected in parallel through different ground lines, the signal terminals of the temperature sensors in the same column group are connected to the same dual-purpose signal line, and the signal terminals of the temperature sensors in different column groups are connected in parallel through different dual-purpose signal lines; and an adapter electrically connected to the electrode sheet and the electric field generator, the adapter corresponding to the electrode sheet is provided with a plurality of ground switches and a plurality of bidirectional switches, wherein the number of bidirectional switches is greater than or equal to the number of dual-purpose signal lines and / or the number of ground switches is greater than or equal to the number of ground lines; at least part of the ground switches are respectively connected to the ground lines of the electrode sheet one by one, at least part of the bidirectional switches are respectively electrically connected to the dual-purpose signal lines of the electrode sheet one by one, the bidirectional switches have an input terminal for connecting an alternating current signal and a sampling terminal for connecting a direct current signal for temperature acquisition, and are configured to transmit an alternating current signal to the dielectric elements of the corresponding electrode units through the dual-purpose signal lines electrically connected thereto when the input terminal is connected to an alternating current signal, or transmit a direct current signal to the signal terminals of the corresponding temperature sensors through the dual-purpose signal lines electrically connected thereto when the sampling terminal is connected to a direct current signal; when the input terminals of at least part of the bidirectional switches are connected to an alternating current signal, all the ground switches are disconnected; when the input terminals of all the bidirectional switches are disconnected and the sampling terminals of at least part of the bidirectional switches are connected to a direct current signal, at least part of the ground switches are turned on one by one.

10. The tumor electric field treatment system of claim 9, wherein, The bidirectional switches not connected to the dual-purpose signal lines are in an idle and disconnected state, and / or the ground switches not connected to the ground lines are in an idle and disconnected state.

11. A tumor electric field treatment system according to claim 9 or 10, characterized in that, The adapter corresponding to the electrode sheet is provided with four ground switches and five bidirectional switches.

12. The tumor electric field treatment system of claim 9 or 10, wherein, The electrode piece is provided with a handshake chip, the adapter is configured to send a handshake signal to the handshake chip and receive a feedback signal of the handshake chip to determine whether it is normally connected with the electrode piece, and after it is normally connected with the electrode piece, the electrode piece is enabled to enter an alternating current signal for tumor treatment or access a direct current signal for temperature collection by configuring the state of each ground switch and each bidirectional switch.

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