Amorphous form and crystal of dioxopiperidine compound or pharmaceutically acceptable salt thereof, preparation method, and use

Improved preparation methods for amorphous and crystalline dioxopiperidine compounds and salts address stability and efficacy issues, enabling their effective use in pharmaceuticals.

HK40135799APending Publication Date: 2026-07-31JIANGSU HENGRUI MEDICINE CO LTD +1
View PDF 0 Cites 0 Cited by

Patent Information

Application Number
HK62026124997
Authority / Receiving Office
HK · HK
Patent Type
Applications
Current Assignee / Owner
Priority Date
2023-05-24
Filing Date
2026-06-18
Publication Date
2026-07-31

AI Technical Summary

Technical Problem

Existing amorphous and crystalline forms of dioxopiperidine compounds and their pharmaceutical salts lack favorable physicochemical properties, which affect their stability and efficacy in pharmaceutical applications.

Method used

Development of amorphous and crystalline forms of dioxopiperidine compounds and their pharmaceutical salts with improved physicochemical properties through specific preparation methods.

Benefits of technology

Enhances the stability and efficacy of dioxopiperidine compounds and their salts, making them suitable for pharmaceutical use.

✦ Generated by Eureka AI based on patent content.

Smart Images

  • Figure 00000029_0000
    Figure 00000029_0000
  • Figure 00000029_0001
    Figure 00000029_0001
  • Figure 00000030_0000
    Figure 00000030_0000
Patent Text Reader

Abstract

The invention relates to an amorphous substance, a crystal, a preparation method and application of a dioxopiperidine compound or a pharmaceutically acceptable salt thereof. Specifically, the invention relates to an amorphous substance and a crystal of a compound as shown in a formula I or a pharmaceutically acceptable salt thereof, and the amorphous substance and the crystal have good physicochemical properties.
Need to check novelty before this filing date? Find Prior Art

Description

(19) State Intellectual Property Office (12) Invention Patent Application (10) Application Publication Number (43) Application Publication Date (21) Application Number 202480029679.9 (22) Application Date 2024.05.24 (66) Domestic Priority Data 202310592195.2 2023.05.24 CN (85) PCT International Application Entering National Phase Date 2025.10.31 (86) PCT International Application Application Data PCT / CN2024 / 095156 2024.05.24 (87) PCT International Application Publication Data WO2024 / 240246 ZH 2024.11.28 (71) Applicant Jiangsu Hengrui Medicine Co., Ltd. Address 222047 No. 7 Kunlunshan Road, Economic and Technological Development Zone, Lianyungang City, Jiangsu Province Applicant: Shanghai Hengrui Pharmaceutical Co., Ltd. (72) Inventors: Zhou Xianqiang, Shang Tingting, Wang Lin, Du Zhenxing, Yang Junran (74) Patent Agency: Shanghai Bixing Law Firm 31283 Patent Attorneys: Gao Xiaoli, Wang Weibin (51) Int.Cl. C07D 471 / 10 (2006.01) A61K 31 / 497 (2006.01) A61P 13 / 08 (2006.01) A61P 35 / 00 (2006.01) (54) Invention Title: Amorphous, Crystallized, Preparation Method and Use of Dioxopiperidine Compound or Pharmaceutical Salt thereof (57) Abstract: This disclosure relates to amorphous, crystallized, preparation method and use of dioxopiperidine compound or pharmaceutical salt thereof. Specifically, this disclosure relates to the amorphous and crystalline forms of the compound shown in Formula I or its pharmaceutically acceptable salts, possessing favorable physicochemical properties. CN 121175309 A 2025.12.19 CN 1 21 17 53 09 A