Immune-stimulating antibody conjugate, preparation method therefor, and use thereof

Abstract

The invention provides an immunostimulatory antibody conjugate as well as a preparation method and application thereof. Specifically, the invention provides an immunostimulatory antibody conjugate as shown in a formula (I), a preparation method of the immunostimulatory antibody conjugate and application of the immunostimulatory antibody conjugate in preparation of drugs for treating and / or preventing cancers, and also provides a drug connector as shown in a formula (II), a compound as shown in a formula III-1, a formula III-2, a formula IV-1 or a formula IV-2, a preparation method of the immunostimulatory antibody conjugate and application of the immunostimulatory antibody conjugate in preparation of the immunostimulatory antibody conjugate.

Description

(19) State Intellectual Property Office (12) Invention Patent Application (10) Application Publication Number (43) Application Publication Date (21) Application Number 202480077225.9 (22) Application Date 2024.12.13 (66) Domestic Priority Data 202311788893.6 2023.12.22 CN (85) PCT International Application Entering National Phase Date 2026.06.05 (86) PCT International Application Application Data PCT / CN2024 / 139222 2024.12.13 (87) PCT International Application Publication Data WO2025 / 130780 ZH 2025.06.26 (71) Applicant Sichuan Kelun Biotech Co., Ltd. Address 611138 No. 666, Section 2, Xinhua Avenue, Cross-Strait Science and Technology Industrial Development Park, Wenjiang District, Chengdu, Sichuan Province (72) Inventors: Liu Jinming, Ren Yun, He Ting, Kang Xiwei, Yuan Xiaoxi, Han Zhu, Tian Qiang, Song Hongmei, Ge Junyou (74) Patent Agency: China Council for the Promotion of International Trade Patent & Trademark Office Co., Ltd. 11038 Patent Attorney: Du Xian (51) Int.Cl. C07K 16 / 28 (2006.01) A61K 47 / 68 (2006.01) A61K 45 / 00 (2006.01) A61P 35 / 00 (2006.01) (54) Invention Title: A Class of Immunostimulatory Antibody Conjugates, Their Preparation Method and Uses (57) Abstract: Provides a class of immunostimulatory antibody conjugates, their preparation method and uses. Specifically, this invention provides an immunostimulatory antibody conjugate of formula (I), a method for its preparation, and its use in the preparation of medicaments for the treatment and / or prevention of cancer. It also provides a drug linker of formula (II) and compounds of formulas III-1, III-2, IV-1, or IV-2, methods for their preparation, and their use in the preparation of immunostimulatory antibody conjugates. CN 122374335 A 2026.07.10 CN 1 22 37 43 35 A

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