Imidazopyrimidines and triazolopyrimidines as a2a / a2b inhibitors

Abstract

This application relates to compounds of Formula (I) or pharmaceutically acceptable salts or stereoisomers thereof, which modulate the activity of adenosine receptors, such as subtypes A2A and A2B receptors, and are useful in the treatment of diseases related to the activity of adenosine receptors including, for example, cancer, inflammatory diseases, cardiovascular diseases, and neurodegenerative diseases.

Description

IMID AZOPYRIMIDINES AND TRIAZOLOPYRIMIDINES AS A2A / A2BThe present invention provides imidazopyrimidine and triazolopyrimidine compounds that modulate the activity of adenosine receptors, such as subtypes A2A and A2B, and are useful in the treatment of diseases related to the activity of adenosine receptors including, for example, cancer, inflammatory' diseases, cardiovascular diseases, and neurode generative diseases.Adenosine is an extracellular signaling molecule that can modulate immune responses through many immune cell types. Adenosine was first recognized as a physiologic regulator of coronary vascular tone by Drury and Szent-Gyorgyu (Sachdeva, S. and Gupta, M. Saudi Pharmaceutical Journal, 2013, 21, 245-253), however it was not until 1970 that Sattin and Rail showed that adenosine regulates cell function via occupancy of specific receptors on the cell surface (Sattin, A., and Rail, T.W., 1970. Mol. Pharmacol. 6, 13-23; Hasko', G., at al, 2007, Pharmacol. Ther. 113, 264-275).Adenosine pla s a vital role in various other ph siological functions. It is involved in the synthesis of nucleic acids, when linked to three phosphate groups; it forms ATP, the integral component of the cellular energy system. Adenosine can be generated by the enzy matic breakdown of extracellular ATP, or can be also released from injured neurons and glial cells by passing the damaged plasma membrane (Tautenhahn, M. et al.Neuropharmacology, 2012, 62, 1756-1766). Adenosine produces various pharmacological effects, both in periphery and in the central nervous system, through an action on specific receptors localized on cell membranes (Matsumoto, T. et al. Pharmacol. Res., 2012, 65, 81- 90). Alternative pathways for extracellular adenosine generation have been described. These pathways include the production of adenosine from nicotinamide dinucleotide (NAD) instead of ATP by the concerted action of CD38, CD203a and CD73. CD73 -independent produc tion of adenosine can also occur by other phosphates such as alkaline phosphatase or prostate- specific phosphatase.There are four known subtypes of adenosine receptor in humans including Al, A2A, A2B, and A3 receptors. Al and A2A are high affinity receptors, whereas A2B and A3 are low affinity receptors. Adenosine and its agonists can act via one or more of these receptors andcan modulate the activity of adenylate cyclase, the enzyme responsible for increasing cyclic AMP (cAMP). The different receptors have differential stimulatory and inhibitory effects on this enzyme. Increased intracellular concentrations of cAMP can suppress the activity' of immune and inflammatory cells (Livingston, M. et al., In fiamm. Res., 2004, 53, 171-178).The A2A adenosine receptor can signal in the periphery and the CNS, with agonists explored as anti-inflammatory' drugs and antagonists explored for neurodegenerative diseases (Carlsson, I. et al., J. Med. Chem., 2010, 53, 3748-3755). In most cell types the A2A subtype inhibits intracellular calcium levels whereas the A2B potentiates them. The A2A receptor generally appears to inhibit inflammatory response from immune cells (Borrmann, T. et al., J. Med. Chem., 2009, 52(13), 3994-4006).A2B receptors are highly expressed in the gastrointestinal tract, bladder, lung and on mast cells (Antonioli, L et ah, Nature Reviews Cancer, 2013, 13, 842-857). The A2B receptor, although structurally closely related to the A2A receptor and able to activate aden late cyclase is functionally different. It has been postulated that this subtype may utilize signal transduction systems other than adenylate cyclase (Livingston, M. et ah, Inflamm. Res., 2004, 53, 171-178). Among all the adenosine receptors, the A2B adenosine receptor is a low affinity receptor that is thought to remain silent under physiological conditions and to be activated in consequence of increased extracellular adenosine levels (Ryzhov, S. et al.Neoplasia, 2008, 10, 987-995). Activation of A2B adenosine receptor can stimulate adenylate cyclase and phospholipase C through activation of Gs and Gq proteins, respectively. Coupling to mitogen activated protein kinases has also been described (Borrmann, T. et al., J. Med. Chem., 2009, 52(13), 3994-4006).In the immune s stem, engagement of adenosine signalin can be a critical regulatory mechanism that protects tissues against excessive immune reactions. Adenosine can negatively modulate immune responses through many immune cell types, including T -cells, natural-killer cells, macrophages, dendritic ceils, mast cells and myeloid-derived suppressor cells (Allard, B. et al. Current Opinion m Pharmacology, 2016, 29, 7-16).In tumors, this pathway is hijacked by tumor micro-environments and sabotages the antitumor capacity of immune s stem, promoting cancer progression. In the tumor microenvironment, adenosine was mainly generated from extracellular ATP by CD39 and CD73. Multiple cell types can generate adenosine by expressing CD39 and CD73. This is the case for tumor cells, T-effector cells, T-regulatory cells, tumor associated macrophages, myeloid derived suppressive cells (MDSCs), endothelial cells, cancer- associated fibroblast (CAFs) and mesenchymal stromal / stem cells (MSCs). Hypoxia, inflammation and other immune- zsuppressive signaling in tumor micro-environment can induce expression of CD39, CD73 and subsequent adenosine production. As a result, adenosine level in solid tumors is unusually high compared to normal physiological conditions.A2A are mostly expressed on l mphoid -derived cells, including T-effecior cells, T regulatory cells and nature killing cells. Blocking A2A receptor can prevent downstream immunosuppressive signals that temporarily inactivate T ceils. A2B receptors are mainly expressed on monocyte-derived cells including dendritic cells, tumor-associatedmacrophages, myeloid derived suppressive ceils (MDSCs), and mesenchymal stromal / stem cells (MSCs). Blocking A2B receptor in preclinical models can suppress tumor growth, block metastasis, and increase the presentation of tumor antigens.In terms of safety profile of ADORA2A / ADORA2B (A2A / A2B) blockage, the A2A and A2B receptor knockout mice are all viable, showing no growth abnormalities and are fertile (Allard, B. et ai. Current Opinion in Pharmacology, 2016, 29, 7-16). A2A KQ mice displayed increased levels of pro-inflammatory cytokines only upon challenge with LPS and no evidence of inflammation at baseline (Antonioli, L. et al.. Nature Reviews Cancer, 2013, 13, 842-857). A2B KG mice exhibited normal platelet, red blood, and white cell counts but increased inflammation at baseline (TNF-alpha, IL-6) in naive A2B KO mice (Antonioli, L. et al., Nature Reviews Cancer, 2013, 13, 842-857). Exaggerated production of TNF-alpha and IL-6 was detected following LPS treatment. A2B KO mice also exhibited increased vascular adhesion molecules that mediate inflammation as well leukocyte adhesion / rolling; enhanced mast-cell activation; increased sensitivity to IgE -mediated anaphylaxis and increased vascular leakage and neutrophil influx under hypoxia (Antonioli, L. et al., Nature Reviews Cancer, 2013, 13, 842-857).In summary, there is a need to develop new adenosine receptor selective ligands, such as for subtypes A2A and A2B, for the treatment of diseases such as cancer, inflammatory diseases, cardiovascular diseases and neurode generative diseases. This application is directed to this need and others.SUMMARYThe present invention relates to, inter alia, compounds of Formula (I):or pharmaceutically acceptable salts thereof, wherein constituent members are defined herein.The present invention further provides pharmaceutical compositions comprising a compound of Formula (I), or a pharmaceutically acceptable salt thereof, and apharmaceutically acceptable carrier.The present invention further provides methods of inhibiting an activity of an adenosine receptor, comprising contacting the receptor with a compound of Formula (I), or a pharmaceutically acceptable salt thereof.The present invention further provides methods of treating a disease or a disorder associated with abnormal expression of adenosine receptors, comprising administering to said patient a therapeutically effective amount of a compound of Formula (I), or apharmaceutically acceptable salt thereof.The present invention further provides a compound of Formula (I), or apharmaceutically acceptable salt thereof for use in any of the methods described herein.The present invention further provides use of a compound of Formula (I), or a pharmaceutically acceptable salt thereof, for the preparation of a medicament for use in any of the methods described herein.DETAILED DESCRIPTIONCompoundsThe present invention relates to, inter alia, compounds of Formula (i):or pharmaceutically acceptable salts thereof; wherein:X is N or CR :R1is selected from H, C -6alkyl, Ci-6haloalkyl, C2-6 alkenyl, C2-6 alkynyl,€6- aryl, C3 -14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-w ar l-Cw alkyl-, C3-14 cycloalkyl-Ci-6 alkyl-, (5-14 membered heteroaiy 1)-C 1-6 alkyl-, (4-14 membered heterocy cloa!ky 1) -C 1-5 alkyl-, ORai, C(0)Rbi, C(0)NRclRdl, C(0)0Rai, C(=NRel)Rbl,C(=NRe!)NR“ 'Rd l, S(0)Rbl, S(0)NRc lRdl, S(0)2Rb l, and S(0)2NRclRdl, wherein the Ci-6alkyl, C2-6alkenyl, C2-6alkynyl, C&-34 aryl, C3-Mcycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, CS-Mar l-Cw alkyl-, C3-14 cycloalkyl-Ci-e alkyl-, (5-14 membered heteroaryl)-C ^ alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6alkyl- of R1are each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected Rdsubstituents;R2is selected from H, D, halo, C -6alkyl, C -6haloalkyl, C2-6alkenyl, C2-6 alkynyl, CV 14 aryl, Cs-w cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, CS-Maryl-Ci-6alkyl-, Cs-u cycloalky l-Ci-6alkyl-, (5-14 membered heteroaryl)-Ci-6alkyl-, (4-14 membered heterocycloalkyl)-Ci-6alkyl-, CN, N02, ORa2, SRa2, NHORai, C(0)Rb2,C(0)NRc2Rd2, C(0)NRe2(0Ra2), C(0)0Ra2, 0C(0)Rb2, 0C(0)NRc2Rd2, NRc2Rd\NRc2NRc2Rd2, NRc2C(0)Rb2, NRc2C(0)0Ra2, NRc2C(0)NRc2Rd2, C(=NRe2)Rb2,C(=NRs2)XRc2Rd2, NRc2C(=NRe2)NRc2Rd2, NRc2C(=NRe2)Rb2, NRc2S(0)NRc2Rd2,NRc2S(0)Rb2, N R SiOi RK'. NRc2S(0)(=NRe2)Rb2, NRc2S(0)2NRc2Rd2, S(0)Rb2,S(0)XRc2Rd2, S(0)2Rb2, S(0)2NRc2Rd2, 0S(0)(=NKe2)Rb2, 0S(0)2Rb2, Si·',. P(0)Ri2Rg2, 0P(0)(0Rh2)(0Rl2), P(0)(0Rb2j(0Rl2), and BRj2Rk2, wherein the Ci Aalkyl, ('·,·. alkenyl,alkynyl, Ci.-n aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 memberedheterocycloalkyl, Ce-w aryl-Ci-6 alkyl-, C3..14 cycloalkyl-Ci-6 alkyl-, (5-14 membered heteroaryl)-Ci-6alkyl-, and (4-14 membered heterocycloalky l)-Ci-6alkyl- of R·are each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected substituents;R3is selected from H, D, halo, Ci-s alkyl, Ci-s haloalkyl, C2-6alkenyl,alkynyl, de¬n ary!, C3-34 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heierocycloalkyl, C * aryl-Ci-6alkyl-, CVw cycloalkyl-Ci-e alkyl-, (5-14 membered heteroaryl)~Ci-6alkyl-, (4-14 membered heterocycloalky l)-Ci-5alkyl-, CN, N02, OK‘k SRJ‘. M)OR::. C(0)Rb3,C(0)NRc3Rd3, C(0)NRc3(0Ra3), C(0)0Ra3, 0C(0)Rb3, 0C(0)XRc3Rd3, NRc3Rd3,NRc3NRc3Rd3, NRc3C(0)Rb3, NRc3C(0)0Ra3, NRc3C(0)NRc3Rd3, C(=NRe3)Rh3,C(=NRe3)NRc3Rd3, NRc3C(=NRe3) Rc3Rd3, NRc3C(-NRe3)Rb3, NRc3S(0) Rc3Rd3,NRc3S(0)Rb3, NRc3S(0) Rb3, NRc3S(0)(=NRe3)Rb3, NRc3S(0)2NRc3Rd3, S(0)Rb3,SiOjN R· Rd. S((); Rh. S(0)2NRc3Rd3, OSiOH Mb iRh. 0S(0)2Rb3, SF5, PiOsR R". OPtOXOR^XQR13), P(0)(0Rh3)(0RL'), and BRjJRk3, wherein the Ci-6alkyl, C2-e alkenyl, C2-6alkynyl, Ce-w aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 memberedheterocycloalkyl, CM* aryl-C -6 alkyl-, C3-14cycloalkyl-C -e alkyl-, (5-14 membered heteroaryl)-Ci-6alkyl-, and (4-14 membered heterocycloalkyl)~C1-6alkyl- of R3are each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R^ substituents;Cy1is Cfs-M aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, or 4-14 membered heterocycloalkyl, wherein the CS-Maryl, Cs-ncycloalkyl, 5-14 membered heteroaryl, or 4-14 membered heterocycloalkyl is optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R11substituents;provided that when X is N and Cy1is 4-14 membered heterocycloalkyl, then the 4-14 membered heterocycloalkyl of Cy1is other than unsubstituted morpholiny!;provided that Cy1is not pyridin-4-yl optionally substituted with i, 2, 3, or 4 independently selected R^ substituents;provided that Cy1is not pyrimidin-4-yl optionally substituted with 1, 2, or 3, independently selected R substituents;provided that Cy1is not quinolin-4-yl optionally substituted with 1 , 2, 3, 4, 5, or 6 independently selected Rbsubstituents;Cy is C&-34aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, or 4-14 membered heierocycloalkyl, wherein the Ce-u aryl, C3-Hcycloalky 1, 5-14 membered heteroaryl, or 4-14 membered heterocycloalkyl is optionally substituted with l, 2, 3, 4, 5, 6, 7, or 8 independently selected Rbsubstituents;each Ra!, Rc l, Rds, Ra2, Rc2, Rd2, Ra3, Rc3, and Rd3is independently selected from H, Ci.6alkyl, C -6haloalkyl,alkenyl, C2-6alkynyl, CX-Haryl, C3U4cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heierocycloalkyl, Ce-n aryl-C3-5alkyl-, Cs-i+cycloalkyl-Ci-e alkyl-, (5-14 membered heteroaryl)-Ci-6alkyl-, and (4- 14 membered heterocycloalkyl)-Ci-6alkyl-,wherein the Cj-e alkyl, C2-6 alkenyl, C2-6 alkynyi, Ce-u aryl,€3-5+ cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C6-Maryl-Ci-6 alkyl-,€3-14 cycloalkyd-C 1-6 alkyl-, (5-14 membered heteroaryl)-C i-e alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6alkyl- of Ral, Rcl, Rdl, Ra2, Rc2, Rd2, Ra5, RcJ, and RdJare each optionally substituted with L 2, 3, 4, 5, 6, 7, or 8 independently selected RGsubstituents;or, any Rciand Ralattached to the same N atom, together with the N atom to which they are attached, form a 5- or 6-membered heteroaryl or a 4-14 membered heterocycloalkyl group, wherein the 5- or 6-membered heteroary l or 4-14 membered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected R° substituents;or any Rc2and Rd2attached to the same N atom, together with the N atom to which they are attached, form a 5- or 6-membered heteroaryl or a 4-14 membered heterocycloalkyl group, wherein the 5- or 6-membered heteroaryl or 4-14 membered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected R° substituents;or any Rc3and Rd3attached to the same N atom, together with the N atom to which they are attached, form a 5- or 6-membered heteroaryl or a 4-14 membered heterocycloalkyl group, wherein the 5- or 6-membered heteroaryl or 4-14 membered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected R&substituents;each Rbl, Rh3, and Rb3is independently selected from H, Ci-6alkyl, Ci-6haloalkyl, C2-6 alkenyl, C2-6 alkynyi, C&.14 aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-i4 aryl-Cs-6alkyl-, Cs-w cycloalkyl-Ci-e alkyl-, (5-14 membered heteroaryl)-Ci.6 alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6 alkyl-, wherein the Ci-6 alkyl, C2-6 alkenyl, C2-6 alkynyi, Ce-w aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-u aryl-Ci-6alkyl-, C3-14 cycloalky l-Ci^ alkyl-, (5-14 membered heteroaryl)-Ci-6 alkyl-, and (4-14 membered heterocycloalkyl)-C½alk l- of Rbl, Rbi, and Rb3are each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R° substituents;each Rei, R5, and Re3is independently selected from H, OH, CN, Ci-6alkyl, Ci-6alkoxy, Cj-6haloalkyl, Ci-ehaloalkoxy, C2-6 alkenyl, C2-6 alkynyi, C6-i4 aryl, C3-Mcycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-w aiyl-Cj-6 alkyl-, G3-Hcycloalkyl-Ci-6alkyl-, (5-14 membered heteroaryl)-C]-6alkyl-, and (4-14 membered heterocy cloalky 1)-C 1.5 alky 1-;each Rg, Rg2, RiJ, and Rg3is independently selected from H, Cj-6alkyl, C]-6aikoxjr, Ci-6haloalkyl, Cj-e haloalkoxy, C2-6 alkenyl, C2-6 alkynyi,€5-54 aryl, 63-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, CM* aryl-Ci-6 alkyl-, C3-14 cycloalkyl-Ci-6 alkyl-, (5-14 membered heteroai l)-Ci-6alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6alkyl-;each R112, Rl2, R!l3, and R1Jis independently selected from H, C -&alkyl, C -&haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C&.14 aryl, C3-1 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, e- aryl-C *-6alkyl-, C3-Kcycioalkyl-C -6 alkyl-, (5-14 membered heteroaryl)-Ci-6alkyl-, and (4-14 membered heterocycloalkyl)~C 1-6 alkyl-;each Rj, Rki, RJC and Rk3is independently selected from OH, C -e alkoxy, and Ci-6haloaikoxy;or any Rj2and Rk2attached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from Ci-6alkyl and C 1-6 haloalkyl;or any RJJand RkJattached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-membered heterocycloalky 1 group optionally substituted with 1, 2, 3, or 4 substituents independently selected from Ci-e alkyl and Ci-6haloalkyl;each Rb, Rc, Rd, Re, Rf, and R° is independently selected from D, halo, oxo, Cj-&alkyl, Ci-6 haloalkyl, C2-e alkenyl, C2-6 alkynyl, C&-14 aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-u ary l-C -6 alkyl-, C3-14 cycloalk l-Cw alkyl- (5-14 membered heteroaryi)-Ci-6 alkyl-, (4-14 membered heterocycloalkyi)-Ci-6 alkyl-, CN, NO2, ORa4, SRa4, NHOR84, C(0)RM, C(0)NRc4Rd4, C(0)NRc4(0Ra4), C(0)0R34. GC(0)Rb4, 0C(0)NRcV , NRc4Rd+, NRc4NRc4Rd4NRc4C(0)RM, NRc4C(0)0Ra4, NRc4C(0)NRc4Rd4,Ci C(=NRe4)NRe4Rd4, NRc4C(===NRe4)NRc4Rd4, N lCCi NRe4S(0)Rb4,NRc4S(0)NRc4Rd4, NRc4S(0)2Rb4, NRc4S(0)(-NRe4)Rb4, NRc4S(0)2NRc4Rd4, S(0)Rb4, S(0)NRc+Rd+, S(0)2Rb+, S(0)2NRc4Rd4, 0S(0)(=NRe4)Rb4, 0S(0)2Rb4, SFs, P(0)Rf4Rg4, 0P(0)(0Rh4)(0R14), P(0)(0Rh4)(0R4), and BR.JRk :. wherein the CMalkyl, C2.6alkenyl, C2..6alkynyl, Ce- aryl, Ch-w cyeloalkyl, 5-14 membered heteroaryl, 4-14 memberedheterocycloalkyl, Ce-u aryl-C 1.5 alkyl-, C3-14 cycloalk I-C1-6 alkyl-, (5-14 membered heteroaryl)-Ci-6alkyl-, and (4-14 membered heterocycloalkyl)-C ue alkyl- of RB, Rc, RD, RE, RF, and R° are each optionally substituted with 1 , 2, 3, 4, 5, 6, 7, or 8 independently selectedRrisubstituents;each Ra4, Rc+, and Rd4is independently selected from H, C i-s alkyl, C i-s haloalkyl, C2-6 alkenyl, C2-6 alkynyl, Ce-u aryd, C3..14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocy cloalkyl, Ce-u aryl-C i-e alkyl-, C3-i cycloalkyl-C -6alkyl-, (5-14 membered heteroaryl)-Ci-6alkyl-, and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-, wherein the Ci-s alkyl, C2-6 alkenyl, C2-6 alkynyl, Cf.- aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14membered heterocycloalkyl, Ce-u aryl-Ci-e alkyl-, Ci-u cycloalkyl-Cj-6 alky' 1-, (5-14 membered heteroaryl)-C]-6 alkyl-, and (4-14 membered heterocycloa3kyl)-Ci-6 alkyl- of Ra\ Rc4, and Rd4are each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected Rrisubstituents;or, any Rc4and Rd4attached to the same N atom, together with the N atom to which they are attached, optionally form a 5- or 6-membered heteroaryl or a 4-14 membered heterocycloalkyl group, wherein the 5- or 6-membered heteroaryl or 4-14 membered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected Rrisubstituents;each Rfc4is independently selected from H, Cne alkyl, Cne haloalkyl, C2-6 alkenyl, C2-6 alkynyl, Ce- aryd, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 memberedheterocycloalkyl, CM* aryl-C [-6 alkyl-, C3-14 cycloalkyl-Cj-e alkyl-, (5-14 membered heteroaryl)-Ci-6alkyl-, and (4-14 membered heterocycloalkyl)~C 1-6 alkyl-, wherein the Ci-s alkyl€2-5 alkenyl, C2-S alkynyl, C&-14 aryd, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl,M* aryl-C i-b alkyl-, C3-Kcycloalkyl-Cj-6 alkyl-, (5-14 membered heteroaryl)-Ci-6alkyl-, and (4-14 membered heterocycloalky l)-Ci-6alkyl- of R°4are each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected RHsubstituents; each R84is independently selected from H, OH, CN, Ci-e alky l, Cj-e alkoxy, Ci-e haloalkyl, Ci-ehaloalkoxy, C2-6 alkenyl, C2-6 alkynyl, Ce-i4 aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-w aryt-Cj-6alkyl-, Cs-w eycloalkyi- Ci-6alkyl-, (5-14 membered heteroaryl) -C1-6 alkyl-, and (4-14 membered heterocycloalky 1)-Ci.6alkyl-;each Rf4and Rg4is independently selected from H, C --6alkyl, Ci-e alkoxy, Ci-6haloalkyl, Ci-ghaloalkoxy, C2-6 alkenyl,€2-5 alkynyl,aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-u aryl-C i-b alkyl-, C3-14 cycloalkyl- Ci-dalkyl-, (5-14 membered heteroaiyl)-Ci-6alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6alkyl-;each RMand R14is independently selected from H, Ci-s alkyl, Ci^ haloalkyl, C2-6 alkenyl,€2-6 alkynyl, Ce-w aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-i4 aryl-Cj-e alkyd-, Cs-w cycloalkyi-Ci-e alkyl-, (5-14 membered heteroaiyl)-Ci-6alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6alkyl-;each Rj4and RK4is independently selected from OH, Cj-saikoxy, and Ci-ehaloalkoxy;or, any Rj4and Rk+attached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from Cne alkyl and Cj-6haloalkyl; each RHis independently selected from D, halo, oxo, Ci-6alkyl, Ci-6haloalkyl, C2-6alkenyl, C2-&alkynyl, Ce-u aryl, CB-Hcycloalkyl, 5-14 tnembered heteroaryd, 4-14 membered heterocycloalkyl, Ce-n aiyl-Ci-6 alkyl-, Cs-Hcycloalkyi-Ci-e alkyl-, (5-14 membered heteroaryl)-Ci-6 alkyl-, (4-14 membered heterocycloalkyl)-Ci-6 alkyl-, CN, NO2, OR35, SR3",OP(0)(OR:,li)(OR15), P(0)(0R!l5)(0Rl5), and BR5Rk5, wherein the CMalkyl, C2-6alkenyl, C2-6alkynyl, CG-Maryl, CB-Hcycloalky 1, 5-14 membered heteroaryl, 4-14 memberedheterocycloalkyl, Ce-u aryl-C i-e alkyl-, CB-i4 cycloalkyl-Ci-6 alkyl-, (5-14 membered heteroaryl)-Ci-6alkyl-, and (4-14 membered heterocycloalky l)-Ci-6alkyl- of R1 !are each optionally substituted with 1, 2, 3, or 4 independently selected R1substituents;each Ra\ Rc5, and Rd>is independently selected from H, Cj-b alkyl, Cj-b haloalkyl, C2-6 alkenyl, C2-e alkynyl,€5-14 aryl, CB-H cycloalkyl, 5-14 membered heteroaryd, 4-14 membered heterocycloalkyl, Ce-n aryl-C 1 -5 alkyd-, CB-H cycloalkyl-Ci-6 alkyl-, (5-14 membered heteroaryl)-Ci-6alkyl-, and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-, wherein the Ci-e alkyl, C2-&alkenyl, C2-&alkynyl, Ce-w aryl, CB-Mcycloalkyl, 5-14 membered heteroaryd, 4-14 membered heterocycloalkyl, Ce-u aryl-Cj-e alkyl-, CB-Mcycloalky l-Ci^ alkyl-, (5-14 membered heteroaryl)-Ci.6 alkyl-, and (4-14 membered heterocycloalkyl)-C 1-6 alkyl- of R3>, Rc5, and Rd5are each optionally substituted with 1 , 2, 3, or 4 independently selected R1substituents; or any Rcaand Rd5attached to the same N atom, together with the N atom to which they are attached, form a 5- or 6-membered heteroaryd or a 4-14 membered heterocycloalkyl group, wherein the 5- or 6-membered heteroaryd or 4-14 membered heterocycloalkyl group is optionally substituted with 1 , 2, 3, or 4 independently selected R1substituents;each Rb5is independently selected from H, Cue alkyd, Cue haloalkyl, C2-6alkenyl, C2-&alkynyl, C&-14 aryl, CB-Hcycloalk l, 5-14 membered heteroaryl, 4-14 memberedheterocycloalkyl, Ce-u aryd-C i-e alkyl-, C3-i4 cycloalkyd-Ci-6 alkyl-, (5-14 membered heteroaryi)-Ci-6alkyl-, and (4-14 membered heterocycloalkyi)~C 1-6 alkyl-, wherein the Ci-6alkyl, C2-e alkenyl, C2-6alkynyl, C&-J4 aryl, CB-H cycloalkyl, 5-14 membered heteroaryd, 4-14membered heterocycloalkyl, Ce-u aryl-Ci-e alkyl-, Ci-u cycloalkyl-C -6 alky' 1-, (5-14 membered heteroaryl)-C]-6 alkyl-, and (4-14 membered heterocycloa3kyl)-Ci-6 alkyl- of R03are each optionally substituted with 1, 2, 3, or 4 independently selected R1substituents;each Re5is independently selected from H, OH, CN, CMalkyl, Ci-e alkoxy, Ci-6haloalkyl, Ci-ehaloalkoxy, C2-6 alkenyl, C2-6 alkynyl, Ca-u aryl, C;-w cycloalkyi, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-u aiyl-Ci-6alkyl-, Cs-u cycloalkyi- CMalkyl-, (5-14 membered heteroaryl) -C -6alkyl-, and (4-14 membered heterocycioalkyl)-C -6alkyl-;each R6and Rpis independently selected from H, Cm, alkyl, Ci« alkoxy, Ci-6haloalkyl, Ci-6haloalkoxy, C>;-s alkenyl, C2-6 alkynyl, CKaryl, C3-S4 cycloalkyl, 5-14 membered heteroary l, 4-14 membered heterocycloalkyl, CM4 ary l-Ci-6alkyl-, C3-14 cycloalky 1- C [-6alkyl-, (5-14 membered heteroaiyl)-Ci-6alkyl-, and (4-14 membered heteroeycloalkyli-Ci-6alkyl-;each RtDand R15is independently selected from H, C alkyl, CMhaloalkyl, C2-6 alkenyl, C2-6 alkynyl, Ce-w aryl, Cj-w cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce- aryl-C 1.5 alkyl-, C3-14 cycloalky 1-CMalkyl-, (5-14 membered heteroaryl)-Ci-6 alkyl-, and (4-14 membered heterocycloalkyl)-C alkyl-;each Rj5and Rk5is independently selected from OH, Ci-e alkoxy, and C -ehaloalkoxy; or, any R|5and Rtoattached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-mem bered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from CM alkyl and Ci-6haloalkyl;each R!is independently selected from D, halo, oxo, C , alkyl, C , haloalkyl, C2-6 alkenyl, C2-6alkynyl, Ce-u aryl, Cs-u cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-w ary 1-CMalkyl-, C3-14 cycloalkyl-Ci-e alkyl-, (5-14 membered heteroaryl)-C]-6alkyl-, and (4-14 membered heterocycioalkyl)-Ci-6alkyl-, CN, N(¾, ORab, SR®6, NHGRa5, C(0)Rb6, C(0)NRc6Rd6, C(0)NRc6(0Ra6). C(0)GRaf>, GC(G)Rb6,0C(0)NRc6Rd6, NRc6Rdb, NRc6NRc6Rd6, NRc6C(0)Rb6, NRc6C(0)0Ra6, NRc6C(0)NRc5Rd6, C(=NRe6)Rb6, C(=NRe6)NRc6Rd6, NRc6C(=NRe6)NRc6Rd6, NRc6C(=NRe6)Rb6, NRc6S(0)Rb6, NRc6S(G)NRc6Rd6, NRc6S(0)2Rb6, NRc5S(0)(=NRc5)Rb6, NRc6S(0)2NRc5Rd6, S(0)Rb6, S(0)NRc6Rd6, S(0)2Rb6, S(0)2NRc5Rd6, 0S(0)(=NRe6)Rb6, 0S(0)2Kb6, SFs, P(0)Rf6Rg6, OPi OiiOR "ji OR:i. P(G)(ORb6)(OR6), and BR,6Rk6, wherein the CMalkyl, C2-6alkenyl, C2-6 alkynyl, Ca-u aryl, Cfr-w cycloalkyl, 5-14 membered heteroaryl, 4-14 memberedheterocycloalkyl, Ce-i aiyl-Ci-6 alkyl-, Cs-u cycloalkyi-Ci-e alkyl-, (5-14 memberedheteroaryl)-C]-6 alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6 alkyl- of Rlare each optionally substituted with 1 , 2, 3, or 4 independently selected RJsubstituents;each Ra5, Rc6, and Rd6is independently selected from H, C i-s alkyl, C i-s haloalkyl, CMalkenyl, CM alkynyl, C&-14 aryl, C3..14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-u aryd-CMalkyl-, C3-i4 cycloalkyl-Ci-6 alkyl-, (5-14 membered heteroaryl)-Ci-6alkyl-, and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-, wherein the CMalkyl, C2-6alkenyl, C2-6 alkynyl, Ci.-u aryl, CJ-Mcycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-u aryl-Ci-e alkyl-, Ch-Mcycioalkyl-CMalkyl-, (5-14 membered heteroaryi)-Ci-6alkyl-, and (4-14 membered heterocycloalky i)-Ci-6alkyl- of Ra5, RCR, and RdRare each optionally substituted with 1, 2, 3, or 4 independently selected RJsubstituents;or any R06and RdRattached to the same N atom, together with the N atom to winch they are attached, form a 5- or 6-membered heteroary l or a 4-14 membered heterocycloalkyl group, wiierein the 5- or 6-membered heteroaryl or 4-14 membered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected RJsubstituents;each Rb6is independently selected from H, CM alkyl, CM haloalkyl, C2-s alkenyl, C2-6 alkynyl, C&.14 aryl, C3-14 cycloalkyl, 5-14 membered heteroaryi, 4-14 memberedheterocycloalkyl, Ce-w ary I-C1-& alkyl-, C3-14cycloalkyl-Cw alkyl-, (5-14 membered heteroaryl)-C]-6 alkyl-, and (4-14 membered heterocycloalkyi)-Ci-6 alkyl-, wiierein the C alkyl, C2-6 alkenyl, C2-6 alkynyl, C&.14 aryl, C3-14cycloalkyl, 5-14 membered heteroaryi, 4-14 membered heterocycloalkyl, Cs-w aryi-CMalkyl-, CVw cycloalkyl-CMalkyl-, (5-14 membered heteroaryl)-Ci-6alkyl-, and (4-14 membered heterocycloalkyl)-C½alkyl- of Rb6are each optionally substituted with 1 , 2, 3, or 4 independently selected R:' substituents;each R®6is independently selected from H, OH, CN, Ci-e alkyl, Cue lkoxy, Ci-e haloalkyl, Ci-ghaloalkoxy, C2-6 alkenyl, C2« alkynyl, Ce-n aryl, C3-14cycloalkyl, 5-14 membered heteroaryi, 4-14 membered heterocycloalkyl, Ce-u axyl-Ci-e alkyl-, C3-14 cycloalkyl- Ci-dalkyl-, (5-14 membered heteroaryl)-Ci-6alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6alky 1-;each R®and Rs° is independently selected from H, Ci-e alkyl, Ci-e alkoxy, Ci-e haloalkyl, Cwehaloalkoxy, C2-6 alkenyl, C2-f,alkynyl, Ce-w aryl, C3-W cycloalkyl, 5-14 membered heteroaryi, 4-14 membered heterocycloalkyl, Ce-i4 aryl-Cj-6alkyl-, Cs-w cycloalkyi- Ci-6alkyl-, (5-14 membered heteroaryi) -Ci-6alkyl-, and (4-14 membered heterocycloalky 1)-Ci.&alkyi-;each Rh6and R16is independently selected from H, Cj-e alkyl, Cj-b haloalkyl, CMalkenyl, C2-6alkynyl, C&-J4 aryl, C3-14cycloalkyl, 5-14 membered heteroaryi, 4-14 memberedheterocycloalkyl, Ce-w ary l-Ci-6alkyl-, C -i+ cycloalkyl-C -e alkyl-, (5-14 membered heteroaryl)-C]-6 alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6 alkyl-;each Rj6and Rk6is independently selected from OH, C -s alkoxy, and C i-ehaloalkoxy; or, any Rj6and Rk6attached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from Ci-e alkyl and Ci-6haloalkyl; each R:1is independently selected from D, halo, oxo, C -6alkyl, C -6haloalkyl, C2-6 alkenyl, C2-6 alkynyl, Ce-u aryl, Caur cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce- aryl-C1.5alkyl-, C3-14cycloalky I-C1-6alkyl-, (5-14 membered heteroarv'l)-C 1-6 alkyl-, and (4-14 membered heteroeycloalkyl)-C [-s alkyl-, CN, NO2, ORa7,0P(0)(0Rh7)(0R17), P(0)(0Rb7)(0R17), and BRj7Rt7, wherein the Ci-5alkyl, C2.salkenyl, C2.salkynyl, Ct,-u aryl, C3-14cycloalkyl, 5-14 membered heteroaryl, 4- 14 memberedheterocycloalkyl, Ce-w ary' l-Ci-6alkyl-, C -i+ cycloalkyl-C -e alkyl-, (5-14 membered heteroaryl)-Ci-6alkyl-, and (4-14 membered heterocycloalky l)-Ci-6alkyl- of RJare each optionally substituted with 1, 2, 3, or 4 independently selected RKsubstituents;each Ra / , Rc', and Rd' is independently selected from H, Ci-6alkyl, Ci-6haloalkyl, C2-6 alkenyl,€2-6 alkynyl, Ce-w aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C6-i4 aiyl-Ci-6alkyl-, Cs-u cycloalkyi-Ci-e alkyl-, (5-14 membered heteroaiyl)-Ci-6 alkyl-, and (4-14 membered heterocycloalkyl)-C½alkyl- wherein the Ci-6alkyl, C2-6alkenyl, C2-6 alkymyl, Ce-i+ aryl, Ci-n cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-u ary l-Ci-e alkyl-, C3-14 cycloalkyl-Ci^ alkyl-, (5-14 membered heteroaiy'l)-Ci-6alkyl-, and (4-14 membered heterocycloalkyl)-C½alkyl- of R3', Rc, and Rd / are each optionally substituted with 1, 2, 3, or 4 independently selected R substituents; or any Rc' and Rd / attached to the same N atom, together with the N atom to which they are attached, form a 5- or 6-membered heteroaryl or a 4-14 membered heterocycloalkyl group, wherein the 5- or 6-membered heteroaryl or 4-14 membered heterocycloalkyl group is optionally substituted with 1 , 2, 3, or 4 independently selected R substituents;each Rb?is independently selected from H, Ci-b alkyl, Cue haloalkyl, C2-6 alkenyl, C2-e alkynyl, C&-J4 aryl, Cs-u cycloalkyl, 5-14 membered heteroaryl, 4- 14 memberedheterocycloalkyl, Ce-w aryl-Ci-e alkyl-, Cj-i+cycloalkyl-Cj-e alkyl-, (5-14 memhered heteroaryl)-Cj-6alkyl-, and (4-14 membered heterocycloa3kyl)-Ci-6alkyl-, wherein the Cj-6alkyl, C2-6 alkenyl, C2-6 alkyny!, C&-Karyl, Cs-Mcyeloalkyi, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, CS-Mar l-Cw alkyl-, C3-14 cycloalkyl-Ci-e alkyl-, (5-14 membered heteroaryl)-Ci-6alkyi-, and (4-14 membered heterocycioalkyl)-Ci-6alkyl- of Rfc7are each optionally substituted with 1, 2, 3, or 4 independently selected RKsubstituents;each Rc / is independently selected from H, OH, CN, Ci-e alkyl, C2-6 alkenyl, C3-6 alkoxy, Ci-6haloalkyl, Ci-ehaloalkoxy, C2-6 alkynyl, Ce-ir aryl, C3-34 cycloalkyl, 5-14 membered heteroaryl, and 4-14 membered heterocycloalkyl;each R17and Rs?is independently selected from H, Ci-6alkyl, Cj-5 alkoxy, CM;haloalkyl, Ci-ehaloalkoxy, C2-6 alkenyl, C2-6 alkynyl, Ce-w aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-i4 aiyl-Ci-e alkyl-, C3-14 cycloalkyl- Ci-6alkyl-, (5-14 membered heteroaiyll-Ci-g alkyl-, and (4-14 membered heterocycloalkyl)-Ci- s alkyl-;each Rh / and R" is independently selected from H, Ci-s alkyl, CMhaloalkyl, C2-6 alkenyl, C2-6 alkynyl, C&.34 aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, CMar I-C1-&alkyl-, C3-14 cycloalkyl-Ci-e alkyl-, (5-14 membered heteroaryl)-C]-6alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6alkyl-;each RJ / and R*' is independently selected from OH, C 3-6 alkoxy, and Ci-ehaloalkoxy ; or, any RJ' and Rk / attached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from C3-6 alkyl and C [-6haloalkyl;each RKis independently selected from H, D, OH, halo, oxo, CN, C(Q)OH, NH2,NO2, SF5, Cj-dalkyl, C·.5 alkoxy, Ci^haloalkoxy, C- .5 haloalkyl, C2-6 alkenyl,€2-5 alkynyl, C&- 14 aryl, C3-i4cycloalkyl, 5-14 membered heteroaryl, 4-14 inembered heterocycloalkyl, CS-Maiyl-Cj-6alkyl-, C3-14 cycloalky l-Ci-6alkyl-, (5-14 membered heteroaryl)-Ci-6alkyl-, and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-; andwherein any heteroaryl group of any of the above-recited substituents optionally comprises an N-oxide on any ring-forming nitrogenin some embodiments,X is N or CR ;R1is selected from H, Cj-6alkyl, C2-6alkenyl, C2-6alkynyl, and CMhaloalkyl;R2is selected from H, D, halo, C 3 -6 alkyl, C3 -6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, Ce- 1 aryl, C3-34 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-i4aryi-C -6 alkyl-, C3-Mcycloalkyl-Ci-6 alkyl-, (5-14 membered heteroaiyl)-C -6 alky 1-, (4-14 membered heterocycloalkyl)-CMalkyl-, CN, NO?, OR32, SR32, NHQR32, C(0)Rb2,CiOiNR· R:. C(0)NRc2(0Ra2), C(G)ORa2, 0C(0)Rb2, 0C(0)NRc2Rd2, X R R12.N R· X R-' 1 '. NRc2C(0)Rb2, NRc2C(Q)GR32, NRc2C(0)NRc2Rd2, C< X R-'iR1".C(=NRe2)NRc2Rd2, NRc2C(=NRe2)NRc2Rd2, NRc2C(=NRe2)Rb\ NRc2S(0)NRc2Rd2,NRc2S(0)Rb2, NRc2S(0)2Rb2, NRc2S(0)(=NRe2)Rb2, NRc2S(0)2NRc2Rd2, S(0)Rb2,S(0)NRc2Rd2, S(0)3Rb2, S(0)2NRc2Rd2, 0S(0)(=NRe2)Rb2, 0S(0)2Rb2, SF5, P(0)RfiRg2, 0P(0)(0RM)(0R12), R(0)(0K:,ί2)(0K12), and BRj2Rk2, wherein the Ci-6alkyl CMalkenyl CMalkynyl, C&.14aryl, C3-14cycloalkyl, 5-14 membered heteroaryl, 4-14 memberedheterocycloalkyl, CX-w aryl-Cs-6 alkyl-, C3-i4cycloalkyl-Ci-6 alkyl-, (5-14 membered heteroaryl)-C]-6alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6alkyl- of R2are each optionally substituted with 1 , 2, 3, 4, 5, 6, 7, or 8 independently selected Rcsubstituents;R3is selected from H, D, halo, CMalkyl, CMhaloalkyi, CMalkenyl, CMalkynyl, Ce- 14 and, C3.14 cycloalkyl 5-14 membered heteroaryl, 4-14 membered heterocycloalk l, Ce-14 aryd-C -6 alkyl-, C3-14 cycloalkyl-Ci-6 alkyl-, (5-14 membered heteroaryl)-Ci-6 alkyl-, (4-14 membered heterocycloalkyl)-Ci..6alkyl-, CN, NG2, ORa3, SR33, NHGRa3, C(0)Rw,CiOiNR· R;. C(0)NRc3(QRa3), C(0)0Ra3, 0C(0)Rb3, 0C(0)NRc3Rd3, N RdC.NRc3NRc3Rd3, NRc3C(0)Rb3, NRc3C(0)GRa3, NRc3C(0)NRc3Rd3, C(=NRe3)Rb3,C(=NRe3)NRc3Rd3, NRc3C(==NRe3)NRc3Rd3, NRc3C(===NRe3)Rb3, NRc3S(0)NRc3Rd3,NRc3S(G)Rb3, NRc3S(0)2Rb3, NRc3S(0)(=NRe3)Rb3, NRc3S(0)2NRc3Rd3, S(G)Rb3,S(0)NRe3Rd3, S(0)2b3, SiOi -N R- Rd :. 0S(0)(=NRe3)Rb3, OSiOi Rb ;. SF5, P(Q)RaRg3, 0P(0)(0Rh3)(0Ri3), P(0)(0Rh3)(0Ri3), and BRJ3Rk3, wherein the C alkyl, C2-6 alkenyl, C2-6 alkynyl, Ce-u aryl, C3-i4 cycloalkyl, 5-14 membered heteroaiyl, 4-14 memberedheterocycloalkyl, Ce-w ary 1-CM alkyl-, C3-14 cycloalkyl-C alkyl-, (5-14 membered heteroaryl)-Ci-6alkyl-, and (4-14 membered heterocycloalkyl)-CMalkyl- of R3are each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R!)substituents;Cy1is CM4 aryl, CJ-Mcycloalky 3, 5-14 membered heteroaryl, or 4-14 membered heterocycloalkyl, wherein the Ce-u aryl C3-i4cycloalkyl, 5-14 membered heteroaiyl, or 4-14 membered heterocycloalkyl is optionally substituted with l, 2, 3, 4, 5, 6, 7, or 8 independently selected REsubstituents;provided that when X is N and Cy1is 4-14 membered heterocycloalkyl, then the 4-14 membered heterocycloalkyl of Cy!is other than unsubstituted morpholinyl;Cy2is Ce-Haryl, C3-i4 cycloalkyl, 5-14 membered heteroaiyl, or 4-14 membered heterocycloalkyl, wherein the Ce-i4aryl, C3-14 cycloalky 1, 5-14 membered heteroaryl, or 4-14membered heterocycloalkyl is optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected Rbsubstituents;each Ra6 R°2, Rd2, Ra3, Rc3, and Rd3is independently selected from H, Ci-6alkyl, Ci-6haloalkyl, C2-6 alkenyl, C2-6 alkynyl, Ce-u aryl, C3 -14 cycloalkyl, 5-14 membered heteroaryl, 4- 14 membered heterocycloalkyl, C&-Karyl -Ci-s alkyl-, C3-i4cycloalkyl-Ci-6 alkyl-, (5-14 membered heteroaryl)-Ci^ alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6alkyl-, wherein the Cj-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, CM* aryl, C3-W cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C&.J4 ary l-Ci-s alkyl-, C3-i4cycloalkjd-Ci^ alkyl-, (5-14 membered heteroaryl)-Ci-6alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6alkyl- of Ra2, Rc2, Rd2, Ra3, Rc3, and Rd3are each optionally substituted with 1 , 2, 3, 4, 5, 6, 7, or 8 independently selected R<Jsubstituents;or any Rc2and Rd2attached to the same N atom, together with the N atom to which they are attached, form a 5- or 6-membered heteroaryl or a 4-14 membered heterocycloalkyl group, wherein the 5- or 6-membered heteroaryl or 4-14 membered heterocycloalkyl group is optionally substituted with 1 , 2, 3, or 4 independently selected R11substituents;or any RcJand Rd3attached to the same N atom, together with the N atom to which they are attached, form a 5- or 6-membered heteroaryl or a 4-14 membered heterocycloalkyl group, wherein the 5- or 6-membered heteroaryl or 4-14 membered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected R° substituents;each Rb2, and RbJis independently selected from H, Cs-6alkyl, Cs-6haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C&-14 aryl, C3..14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, CM* aiyl-C i-b alkyl-, C3-14 cycloalkyl-Cj-e alkyl-, (5-14 membered heteroaryi)-Ci-6alkyl-, and (4-14 membered heterocycloalkyi)~C 1-6 alkyl-, wherein the Ci-s alkyl,€2-5 alkenyl, C2-Salkynyl, C&-14 aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl,M* aryl-Ci-e alkyl-, C3-i4 cycloalkyl-C] -6 alkyl-, (5-14 membered heteroaryi)-Ci-6alkyl-, and (4-14 membered heterocycloalky 1)-C 1.6 alkyl- of R°2and Rb5are each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R° substituents; each R” and ReJis independently selected from H, OH, CN, CMalkyl, Ci^alkoxy,C [-6 haloalkyl, C;i-f!haloa3koxy, C2-6 alkenyl, C2-6 alkynyl. CM* aiyl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-i4 aryl-Cj-6alkyl-, C3-icycloalkyl- Ci-6alkyl-, (5-14 membered heteroaryl) -Ci-6alkyl-, and (4-14 membered heterocycloalky 1)-Ci.&alkyd-;each Rf2, Rs3, Rf3, and Rs3is independently selected from H, Ci-6alkyl, Ci-e alkoxyy Ci haloalkyl, Cj-ehaloalkoxy, C2-6 alkenyl, C2-6 alkynyi, C&-J4 aryl, C3-u cycloalkyl, 5-14membered heteroaryl, 4-14 membered heterocycloalkyl, CM4 ary l-Ci-6 alkyl-, C3-14 cycloalky 1- C [-6 alkyl-, (5-14 membered heteroaiyl)-Ci-6 alkyl-, and (4-14 membered heterocycloalkyl)-Ci- 6 alkyl-;each Rh, R , Ra3, and R'3is independently selected from H, Ci.&alkyl, Ci.&haloalkyl, C2-6 alkenyl, C2-6 alkynyi, Ce-u aryl, C3-14 eycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-u aryl-Ci-e alkyl-, Cs-u cycloalky l-Ci-6 alkyl-, (5-14 membered heteroaryd)-Ci-6 alkyl-, and (4-14 membered heterocycloalkyl)-C i-e alkyl-;each Rj2, Rk2, R3, and R*3is independently selected from OH, Cwalkoxy, and Ci-e haloalkoxy;or any Rj2and RKattached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from Ci-6alkyl and C 1-6 haloalkyl;or any Rj3and R^3attached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1 , 2, 3, or 4 substituents independently selected from Ci-e alkyl and C ue haloalkyl;each Rc, RD, Rb, Rf, and R° is independently selected from D, halo, oxo, Ci« alkyl, Ci-6haloalkyl, C2-6 alkenyl, C2-6 alkynyi, Ce-u aryl, C3-14 eycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-u ary l-Ci-6alkyl-, Cs-u cycloalkyl-Ci-e alkyl-, (5-14 membered heteroaryl)-Ci-6alkyl-, (4-14 membered heterocycloalky l)-Ci-6alkyl-, CN, N02, OR34, SRa4, NΊ iORnC(0)Rm, C(0)NRc4Rd4, C(0)NRc4(0Ra4), C(0)0Ra4, 0C(0)Rb4, 0C(0)NRc+Rd+, NRc4Rd4, NRc4NRc4Rd4NRc4C(0)RM, NRc4C(0)GR34, NRc4C(0)NRc4Rd4,('·; X R ' i R'i C(=NRe4)NRc4Rd4, NRc4C(=NRe4)NRc4Rd4, NRc4C(=NRe4)Rb4, NRc4S(0)Rb4, NRC4S(0)NRC4R14, NRc4S(0)2Rb4, NRc4S(0)(=NRe4)Rb4, NRc4S(0)2NRc+Rd4, S(0)Rw, S(0)NRe4Rd4, S(0)2Rb4, S(0)2NRc+Rd4, 0S(0)(-NRe4)Rb4, 0S(0)2RM, SF5, P(0)Rf4Rg4, 0P(0)(0RM)(0R4), P(0)(0R“4)(0Ri4), and BR4Rk4, wherein the CM alkyl, C2-6 alkenyl, C2-6 alkynyi, Ce-u aryl, C3-14 eycloalkyl, 5-14 membered heteroaryl, 4-14 memberedheterocycloalkyl, Ce-u ary 1-Ci-e, alkyl-, C3-14 cycloalkyl-Ci-e alkyl-, (5-14 membered heteroaryl)-C]-6 alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6 alkyl- of Rc, RD, R11, Rb, and R'Jare each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected Rhsubstituents;each R34, Rc4, and Rd4is independently selected from H, Ci-6alkyl, Ci-6haloalkyl, C -&alkenyl, C2-&alkynyi, CVu aryl, Cj-u eycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-u aryl-Ci-6alkyl-, Cs-u cycloalkyi-Ci-e alkyl-, (5-14 membered heteroaryl)-Ci^ alkyl-, and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-, wherein the Ci-6alkyl, C2-6 alkenyl, C2-6 a!kynyl, Ce-i+aiyl, C3-14 cycloalkyl, 5-14 membered heteroaiyl, 4-14 membered heterocycloalkyl, C -u aryl-Ci-e alkyl-, C3-Mcycloalky 1-Ci-e alkyl-, (5-14 membered heteroatyl)-C 1-6 alkyl-, and (4-14 membered heteroeyeloalkyl)-Ci-s alkyl- of Ra4, Rc4, and Rd4are each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected Rhsubstituents;or, any Rc4and Ra4attached to the same N atom, together with the N atom to which they are attached, optionally form a 5- or 6-membered heteroaryl or a 4-14 membered heterocycloalkyl group, wherein the 5- or 6-membered heteroaryl or 4-14 membered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected RMsubstituents;each Rwis independently selected from H, Ci-6alky l, Ci-e haloalkyi, C2-6 alkenyl, C2-0 alkynyl, Ce-w aryl, C3-H cycloalkyl, 5-14 membered heteroaiyl, 4-14 memberedheterocycloalkyl, Cg-ir aiyl-Ci-6 alkyl-, Cs-u cycloalkyl-Ci-e alkyl-, (5-14 membered heteroaryl)-Ci.6 alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6 alkyl-, wherein the Ci-e alkyl, C2-6 alkenyl, C2-6 alkynyl, CMaryl, Ci-Kcycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Cs-w aryi-Cj-g alkyl-, C3-14 cycloalky l-Ci-6 alkyl-, (5-14 membered heteroaryl)-Ci-6 alkyl-, and (4-14 membered heterocycloalkyl)-C i-e alkyl- ofR04are each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected RHsubstituents; each Re4is independently selected from H, OH, CN, Ci..g alkyl, Ci..g alkoxy , Ci-g haloalkyi, Cj-ghaloalkoxy, C2-6 alkenyl, C2-6 alkynyl, Cg-k aryl, Cs-ir cycloalkyl, 5-14 membered heteroaiyl, 4-14 membered heterocycloalkyl, Cg-14 ary l-Ci-6alkyl-, C3..14 cycloalky 1- C [-6alkyl-, (5-14 membered heteroaryfi-Ci- alkyl-, and (4-14 membered heteroeycloalkyli-Ci-6alkyl-;each Rf4and R84is independently selected from H, Ci-e alkyl, Ci-6alkoxy, Ci^ haloalkyi, Ci-ehaloalkoxj , C2-6 alkenyl, C2-6 alkynyl, Ca-u aryl, C3-i4 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C&-u aryd-Ci-e alkyl-, C3-1 cycloalky 1- Ci-f,alkyl-, (5-14 membered heteroaryl) -Cj-6alkyl-, and (4-14 membered heterocyc!oalkyl)-Cj-6alkyl-;each Rh4and R14is independently selected from H, Ci-6alkyl, C1-6 haloalkyi, C2-6 alkenyl, C2-6alkynyl, C&-14 aryl, C-t-u cycloalkyl, 5-14 membered heteroaiyl, 4-14 membered heterocycloalkyl, Ce-w ary l-Ci-6 alkyl-, C3-14 cycloalkyl-Cw alkyl-, (5-14 membered heteroaryl)-Ci-6alkyl-, and (4-14 membered heterocycioalkyi)-Cs-6alkyl-;each R·'4and Rk4is independently selected from OH, Cj-g alkoxy, and Ci-ghaloalkoxy;or, any Rj4and Rk+attached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from Cj-6alkyl and Cj-6haloalkyl; each RHis independently selected from D, halo, oxo, Ci-6alkyl, Ci-6haloalkyl, C2-6alkenyl, C2-6alkynyl, Ce-w aryl, Cj-w cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-ir aiyl-Ci-6 alkyl-, Cs-u cycloalkyi-Ci-e alkyl-, (5-14 membered heteroaryl)-Ci-6 alkyl-, (4-14 membered keterocycloalkyl)-Ci-6 alkyl-, CN, NO2, OR35, SR3", NHORa5, C(0)Rb5, (';())>. R"'R;i". C(0)NRc5(0Ra5), C(0)0Ra5, 0C(0)Rb5, 0C(0)NRc5Rd5, NRc5Rd5, NRc5NRc5Rd5,NRc5C(0)Rb5, NRc5C(0)GRa5, NRc5C(0)NRc5Rd5, C(===NRe5)Rb5, C(=NRsi)NRc5Rd5, NRc5C(=NRe5)NRc5Rd5, NRc5C(=NRe5)Rb5, NRc5S(0)Rbi,NRc5S(0)NRc5Rd5, NRc5S(0)2Rb5, NRc5S(0)(=NRe5)Rb5, NRc5S(0)2NRc5Rd5, S(0)Rb5,SiOiN R'R!\ S(0)2Rb5, S(0)2NRc5Rd5, 0S(0)(=NRe5)Rb5, 0S(0)2Rb5, SFs, P(0)Rf5Rg5, 0P(0)(0R:,li)(0R15), P(0)(0R!l5)(0Rl5), and BR5Rk5, wherein the CMalkyl, C2-6alkenyl, C2-6alkynyl, C&-1 aryl, C3-14 cycloalky 1, 5-14 membered heteroaryl, 4-14 memberedheterocycloalkyl, Ce-u aryl-C i-e alkyl-, C3-i4 cycloalkyl-Ci-6 alkyl-, (5-14 membered heteroaryl)-Ci-6alkyl-, and (4-14 membered heterocycloalky l)-Ci-6alkyl- of R1 !are each optionally substituted with 1, 2, 3, or 4 independently selected R1substituents;each R85, Rc5, and Rd>is independently selected from H, Ci-e alkyl, Ci-e haloalkyl, C2-6 alkenyl, C2-e alkynyl, C<5-i4 aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-i4 aryl-Cj-e alkyd-, Cs-w cycloalkyi-Ci-e alkyl-, (5-14 membered heteroaryl)-Ci.6 alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6 alkyl-, wherein the Ci-e alkyl, C2-6alkenyl, C2-&alkynyl, Ce-w aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-u aryl-Cj-e alkyl-, C3-14 cycloalky 1-Cw alkyl-, (5-14 membered heteroaryl)-Ci-6alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6alkyl- of R3>, Rc5, and Rd5are each optionally substituted with 1 , 2, 3, or 4 independently selected R1substituents; or any Rcaand Rd5attached to the same N atom, together with the N atom to which they are attached, form a 5- or 6-membered heteroaryl or a 4-14 membered heterocycloalkyl group, wherein the 5- or 6-membered heteroaryl or 4-14 membered heterocycloalkyl group is optionally substituted with 1 , 2, 3, or 4 independently selected R1substituents;each Rb5is independently selected from H, Cue alkyl. Cue haloalkyl, C2-6alkenyl, C2-6alkynyl, C&-14 aryl,€3-14 cycloalky 1, 5-14 membered heteroaryl, 4-14 memberedheterocycloalkyl, Ce-u aryd-C i-e alkyl-, C3-.4 cycloalkyl-C] -6 alkyl-, (5-14 membered heteroaryl)-Ci-6alkyl-, and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-, wherein the Ci-6alkyl, C2-e alkenyl, C2-e alkynyl, C&-J4 aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14membered heterocycloalkyl, Ce-u aryl-Ci-e alkyl-, Ci-u cycloalkyl-C -6 alky' 1-, (5-14 membered heteroaryl)-C]-6 alkyl-, and (4-14 membered heterocycloa3kyl)-Ci-6 alkyl- of R03are each optionally substituted with 1, 2, 3, or 4 independently selected R1substituents;each Re5is independently selected from H, OH, CN, CM alkyl, Ci-e alkoxy, Ci-6haloalkyl, Ci-ehaloalkoxy, C2-6 alkenyl, C2-6 alkynyl, Ca-u aryl, C;-w cycloalkyi, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-u aiyl-Ci-6alkyl-, Cs-u cycloalkyi- CM, alkyl-, (5-14 membered heteroaryl) -C -6alkyl-, and (4-14 membered heterocycioalkyl)-C -6alkyl-;each R6and Rpis independently selected from H, Cm, alkyl, Ci«alkoxy, Ci-6haloalkyl, Ci-6haloalkoxy, C>;-s alkenyl, C2-6 alkynyl, CKaryl, C3-Hcycloalkyl, 5-14 membered heteroary l, 4-14 membered heterocycloalkyl, CM4 ary l-Ci-6alkyl-, C3-14cycloalky 1- C [-6alkyl-, (5-14 membered he teroaryli-Ci-f, alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6alkyl-;each RtDand R15is independently selected from H, C alkyl, CMhaloalkyl, C2-6 alkenyl, C2-6 alkynyl, Ce-w aryl, Cj-w cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce- aryi-C 1.5 alkyl-, C3-1 cycloalky l-Ci-6 alkyl-, (5-14 memberedheteroaryl)-Ci-6 alkyl-, and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;each Rj5and Rk5is independently selected from OH, Ci-salkoxy, and C -ehaloalkoxy; or, any R|5and Rtoattached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-mem bered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from CM alkyl and Ci-6haloalkyl;each R!is independently selected from D, halo, oxo, C , alkyl, C , haloalkyl, C2-6 alkenyl, C2-6alkynyl, Ce-u aryl, Cs-ucycloalkyi, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-w ary 1-CMalkyl-, C3-14 eyeloalkyl-Ci-e alkyl-, (5-14 membered heteroaryl)-Ci-6alkyl-, and (4-14 membered heterocycloalkyl)-C]-6alkyl-, CN, N(¾, ORab, SR®6, NHORa5, C(0)Rb6, C(0)NRc6Rd6, C(G)NRc6(ORa6). C(0)ORaf>, OC(0)Rb6,0C(0)NRc6Rd6, NRc6Rdb, NRc6NRc6Rd6, NRc6C(0)Rb6, NRc6C(0)0Ra6, NRc6C(0)NRc5Rd6, C(=NRe6)Rb6, C(=NRe6)NRc6Rd6, NRc6C(=NRe6)NRc6Rd6, NRc6C(=NRe6)Rb6, NRc6S(0)Rb6, NRc6S(0)NRc6Rd6, NRc6S(0)2Rb6, NRc5S(0)(=NRc5)Rb6, NRc6S(0)2NRc5Rd6, S(0)Rb6, S(0)NRc6Rd6, S(0)2Rb6, S(0)2NRc6Rd6, 0S(0)(=NRe6)Rb6, 0S(0)2Kb6, SFs, P(0)Rf6Rs6, 0P(0)(0Rh6)(0Rl6), P(0)(0Rb6)(0R6), and BR,6Rk6, wherein the CMalkyl, C2-6alkenyl, C2-6 alkynyl, Ca-u aryl, Cfr-w cycloalkyi, 5-14 membered heteroaryl, 4-14 memberedheterocycloalkyl, Ce-ir aiyl-Ci-6 alkyl-, Cs-u cycloalkyi-Ci-e alkyl-, (5-14 memberedheteroaryl)-C]-6 alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6 alkyl- of Rlare each optionally substituted with 1 , 2, 3, or 4 independently selected RJsubstituents;each Ra5, Rc6, and Rd6is independently selected from H, C i-s alkyl, C i-s haloalkyl, C2-6alkenyl, C2-s alkynyl, C&-14 aryl, C3..14cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-u aryd-C i-e alkyl-, C3-i4eyeloalkyl-Cj-6alkyl-, (5-14 membered heteroaryl)-Ci-6alkyl-, and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-, wherein the Ci-s alkyl, C2-6alkenyl, C2-6 alkynyl, Ci.-u aryl, CJ-Mcycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-u aryl-Ci-e alkyl-, Cs-u cycloalkyl-Cj-e alkyl-, (5-14 membered heteroaryi)-Ci-6alkyl-, and (4-14 membered heterocycloalky i)-Ci-6alkyl- of Ra5, RCR, and RdRare each optionally substituted with 1, 2, 3, or 4 independently selected RJsubstituents;or any R06and RdRattached to the same N atom, together with the N atom to winch they are attached, form a 5- or 6-membered heteroary l or a 4-14 membered heterocycloalkyl group, wiierein the 5- or 6-membered heteroaryl or 4-14 membered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected RJsubstituents;each Rb6is independently selected from H, Cj-6alkyl, Cj-6haloalkyl, C2-s alkenyl, C2-6 alkynyl, C&.14 aryl, C3-14 cycloalkyl, 5-14 membered heteroaryi, 4-14 memberedheterocycloalkyl, Ce-w ary I-C1-& alkyl-, C3-14 cycloalkyl-Ci-e alkyl-, (5-14 membered heteroaryl)-C]-6 alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6 alkyl-, wiierein the Cj-e alkyl, C2-6 alkenyl, C2-6 alkynyl, C&.14 aryl, C3-14 cycloalkyl, 5-14 membered heteroaryi, 4-14 membered heterocycloalkyl, Cs-w aryi-Cj-6alkyl-, CVw cycloalkyl-C i-e alkyl-, (5-14 membered heteroaryl)-Ci-6alkyl-, and (4-14 membered heterocycloalkyl)-C½alkyl- of Rb6are each optionally substituted with 1 , 2, 3, or 4 independently selected R:' substituents;each R®6is independently selected from H, OH, CN, Ci-e alkyl, Cue lkoxy, Ci-e haloalkyl, Ci-ghaloalkoxy, C2-6 alkenyl, C2« alkynyl, Ce-n aryl, C3-14cycloalkyl, 5-14 membered heteroaryi, 4-14 membered heterocycloalkyl, Ce-u axyl-Ci-e alkyl-, C3-14 cycloalkyl- Ci-dalkyl-, (5-14 membered heteroaryl)-Ci-6 alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6alky 1-;each R®and Rs° is independently selected from H, Ci-e alkyl, Ci-e alkoxy, Ci-e haloalkyl, Cwehaloalkoxy, C2-6 alkenyl, C2-f,alkynyl, Ce-w aryl, C3-W cycloalkyl, 5-14 membered heteroaryi, 4-14 membered heterocycloalkyl, Ce- 14 aryl-Cj-6alkyl-, Cs-w cycloalkyi- Ci-6alkyl-, (5-14 membered heteroaryi) -Ci-6alkyl-, and (4-14 membered heterocycloalky 1)-Ci.&alkyi-;each Rh6and R16is independently selected from H, Cj-e alkyl, Cj-e haloalkyl, C2_6 alkenyl, C2-e alkynyl, C&-J4 aryl, C3-14 cycloalkyl, 5-14 membered heteroary i, 4-14 memberedheterocycloalkyl, Ce-w ary l-Ci^ alkyl-, Cs-i+ cycloalkyl-C -e alkyl-, (5-14 membered heteroaryl)-C]-6 alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6 alkyl-;each Rj6and Rk6is independently selected from OH, C -s alkoxy, and C i-ehaloalkoxy; or, any Rj6and Rk6attached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from C -e alkyl and Ci-6haloalkyl; each R:1is independently selected from D, halo, oxo, C -6alkyl, C -6haloalkyl, C2-6 alkenyl, C2-6 alkynyl, Ce-u aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce- aryl-C 1.5 alkyl-, C3-1 cycloalky I-C1-6 alkyl-, (5-14 membered heteroaryl)-C 1-6 alkyl-, and (4-14 membered heteroeyeloalkyl)-C i-s alkyl-, CN, NC¾, OR37,SR37, NHOR37, C(0)Rb7, C(0)NRc7Rd7, C(0)NRc7(0Ra7), C(0)0Ra7, 0C(0)Rb7,OC (0)NRc7Rd7, NRc7Rd7, NRc7NRc7Rd7,NRc7C(0)Rb7, NRc7C(0)0Ra7, NRc7C(0)NRc7Rd7, C(=NRe7)Rb7, C(=NRe7)NRc7Rd7, NRc7C(=NRe7)NRc7Rd7, NRc7C(=NRe7)Rb7, NRc7S(0)Rb7, NRc7S(0)NRc7Rd7, NRc7S(0)2Rb7, NRc7S(0)(=NRe7)Rb7, NRc7S(0)2NRc7Rd7, S(0)Rb?, S(())N R R!. S(()) .RbS(0)2NRc7Rd7, 0S(0)(=NRe7)Rb7, 0S(0)2Rb7, Si·,. P(0)Ri7Rg7, 0P(0)(0Rh7)(0R17), P(0)(0Rb7)(0R17), and BRj7Rt7, wherein the Ci-5alkyl, C2-& alkenyl, C2.salkynyl, Ct,-u aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4- 14 memberedheterocycloalkyl, Ce-w ary 1-C 1-6 alkyl-, C -ir cycloalkyl-C -e alkyl-, (5-14 membered heteroaryl)-Ci-6alkyl-, and (4-14 membered heterocycloalky l)-Ci-6alkyl- of RJare each optionally substituted with 1, 2, 3, or 4 independently selected RKsubstituents;each Ra / , Rc', and Rd' is independently selected from H, Ci-6alkyl, Ci-e haloalkyl, C2-6 alkenyl,€2-6 alkynyl, Ce-w aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-ir aryl-Ci-6 alkyl-, Cs-u cycloalkyi-Ci-e alkyl-, (5-14 membered heteroatyl)-Ci-6alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6alkyl- wherein the Ci-6alkyl, C2-6 alkenyl, C2-6 alkynyl, C6-i4 aryl, Ci-Hcycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-u ary l-Ci-e alkyl-, C3-14 cycloalkyl-Ci-e alkyl-, (5-14 membered heteroaryd)-Ci-6 alkyl-, and (4-14 membered heterocycloalkyl)-C i-e alkyl- of R3', Rc, and Rd / are each optionally substituted with 1, 2, 3, or 4 independently selected R*substituents; or any Rc' and Rd / attached to the same N atom, together with the N atom to which they are attached, form a 5- or 6-membered heteroaryl or a 4-14 membered heterocycloalkyl group, wherein the 5- or 6-membered heteroaryl or 4-14 membered heterocycloalkyl group is optionally substituted with 1 , 2, 3, or 4 independently selected R substituents;each Rb?is independently selected from H, Ci-6alkyl, Ci-6haloalkyl, C2-6 alkenyl, C2-6 alkynyl, Ci.-n aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4- 14 memberedheterocycloalkyl, Ce-u ary l-Ci-6 alkyl-, C -i+cycloalkyl-C -e alkyl-, (5-14 membered heteroaryl)-C]^ alkyl-, and (4-14 membered heterocycloa3kyl)-Ci-6alkyl-, wherein the Cj-6 alkyl, C?_-6alkenyl, C2-6 aikynyl, C&-Karyl,€3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, CS-Mar l-Cw alkyl-, C3-14 cycloalkyl-Cs-e alkyl-, (5-14 membered heteroaryl)-Ci-6 aikyl-, and (4-14 membered heterocycloalkyl)-C]-6alkyl- of Rfc7are each optionally substituted with 1, 2, 3, or 4 independently selected RKsubstituents;each Rc / is independently selected from H, OH, CN, C3-6 alkyl, C2-6 alkenyl, C3-6 alkoxy, Ci^haloalkyi, Ci-ehaloalkoxy, C2-6aikynyl, C6-i4aryl, C3-34 cycloalkyl, 5-14 membered heteroaryl, and 4-14 membered heterocycloalkyl;each R17and Rs?is independently selected from H, Ci-6alkyl, Cs-6alkoxy, CM>haloalkyl, Ci-ehaloalkoxy, C2-6 alkenyl, C2-6 aikynyl, Ce- aryl, C3-i4 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, CM 4aiyl-Ci-e alkyl-, C3-34cycloalkyl- Ci-6alkyl-, (5-14 membered heteroaiyll-Ci-g alkyl-, and (4-14 membered heterocycloalkyl)-C].s alkyl-;each Rh / and R1' is independently selected from H, Ci-s alkyl, Ci-b haloalkyl, C2-6 alkenyl, C2-6 aikynyl, C&.24aryl, C3-14cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-w ar I-C1-& alkyl-, C3-14cycloalkyl-Cr-e alkyl-, (5-14 memberedheteroaryl)-C]-6alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6alkyl-;each RJ / and R*' is independently selected from OH, C 3-6 alkoxy, and Ci-ehaloalkoxy ; or, any RJ' and Rk / attached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from C -6 alkyl and C -6haloalkyl;each RKis independently selected from H, D, OH, halo, oxo, CN, C(0)0H, NH2,NO2, SF5, C -dalkyl, C·.5 alkoxy, Ci^haloalkoxy, C- .5 haloalkyl, C2-6 alkenyl,€2-5 aikynyl, C&- 14 aryl, C3U4 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, CS-Maiyl-C -6 alkyl-, C3-i4 cycloalky l-Ci-6alkyl-, (5-14 membered heteroaryl)-Ci-6 alkyl-, and (4-14 membered heterocycloalkyl)-C -6 alkyl-; andwherein any heteroaryl group of any of the above-recited substituents optionally comprises an N-oxide on any ring-forming nitrogen.In some embodiments,X is CR :R1is selected from H, C -6alkyl, C -6haloalkyl, C2-6 alkenyl, C2-6 aikynyl,€6- aryl, Cb-4cycloalkyl, 5-14 membered heteroaryd, 4-14 membered heterocycloalkyl, Ce-ir aryi-C -e alkyl-, C3-34cycloalkyl-Cs-e alkyl-, (5-14 membered heteroaryl)-C 3-6 alkyl-, (4-14 memberedheterocycloalkyl)-Ci-6alkyl-, ORai, C(0)Rbl, C(0)NRclRdl, C(0)0Ral, C(=NRel)Rbl, C(=NRe!)NR“ 'Rd l, S(0)Rbl, S(0)NRc lRdl, S(0)2Rb l, and S;()i \R' :R:I ;. wherein the Ci-6aikyi, C‘ alkenyl, C2-6 alkynyl, C&-Kaxyl, CB-Mcycloalkyl, 5-14 mem bered heteroaryl, 4-14 membered heterocycloalkyl, CS-Mar l-Cw alkyl-, C3-14 cycloalkyl-Ci-e alkyl-, (5-14 membered heteroaryl)-Ci-6aikyl-, and (4-14 membered heterocycloalkyl)-C]-6aikyi- of R1are each optionally substituted with i, 2, 3, 4, 5, 6, 7, or 8 independently selected Rdsubstituents;R2is selected from H, D, halo, C -6alkyl, C -6haloalkyl, C2-6alkenyl, C2-6 alkynyl, C i4 aryl, Cs- cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, CS-Maryl-Ci4s alkyl-, Cs-u cycloalky l-Ci-6alkyl-, (5-14 membered heteroaryl)-Ci-6alkyl-, (4-14 membered heterocycloalkyl)-C!-e alkyl-, CN, N<¾, OR82, SR32, NHOR32, C(0)Rb2,C(0)NRc2Rd2, C(0)NRe2(0Ra2), C(0)0Ra2, 0C(0)Rb2, 0C(0)NRc2Rd2, NRc2Rd2,NRc2NRc2Rd2, NRc2C(0)Rb2, NRc2C(0)0Ra2, NRc2C(0)NRc2Rd2, C(=NRe2)Rb2,C(=NRe2)NRc2Rd2, NRc2C(=NRe2)NRc2Rd2, NRc2C(=NRe2)Rb2, NRc2S(0)NRc2Rd2,NRc2S(0)Rb2, N R S;()i RK'. NRc2S(0)(=NRe2)Rb2, NRc2S(0)2NRc2Rd2, S(G)Rb2,S(0)NRc2Rd2, S(0)2Rb2, S(0)2NRc2Rd2, 0S(0)(=NRe2)Rb2, 0S(0)2Rb2, Si·',. P(0)Ri2Rg2, 0P(0)(0Rh2)(0Rl2), P(0)(0Rb2)(0R12), and BRj2Rk2, wherein the C;,·. alkyl, ('·,·, alkenyl, ('·,·. alkynyl, C&-J4 aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 memberedheterocycloalkyl, Ce-w ary i-C 1-6 alkyl-, Ca-i+cycloalkyl-C -e alkyl-, (5-14 membered heteroaryl)-Ci-6alkyl-, and (4-14 membered heterocycloalky l)-C 1.6 alkyl- of R·are each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R substituents;R;iis selected from H, D, halo, Ci.&alkyl, Ci.&haloalkyl, C2..e alkenyl, C2-6 alkynyl, Ce- i4 aryl, C3-34cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, CM* aryl-C -6alkyl-, Cs-Hcycloaikyl-C 1-6 alkyl-, (5-14 membered heteroaryi)~Ci-6alkyl-, (4-14 membered heterocycloalky l)-Ci-5alkyl-, CN, NO...ORa3, SR fr M )OR::. C(0)Rb3,C(0)NRc3Rd3, C(0)NRc3(0Ra3), C(0)0Ra3, 0C(0)Rb3, 0C(0)NRc3Rd3. NRc3Rd3,NRc3NRc3Rd3, NRc3C(0)Rb3, NRc3C(0)GRa3, NRc3C(G)NRc3Rd3, C(===NRe3)Rh3,C(=NRe3)NRc3Rd3, NRc3C(=NRe3)NRc3Rd3, NRc3C(=NRe3)Rb3, NRc3S(0)NRc3Rd3,NRc3S(0)Rb3, NRc3S(0)2Rb3, NRc3S(0)(-NRe3)Rb3, NRc3S(0)2NRc3Rd3, S(0)Rb3,SiOiN R· R;i. Si()) RhS(0)2NRc3Rd3, 0S(0)(=NRe3)Rb3, 0S(0)2Rb3, SF5, Pi())R"R"\ 0P(0)(0Rn3)(0Rl3), P(0)(0Rb3)(0RL''), and BRjJRk3, wherein the Ci-6 alkyl, C2-5 alkenyl, C2-6alkynyl, C&-14 aryl,€3-14 cycloalky 1, 5-14 membered heteroaryl, 4-14 memberedheterocycloalkyl, Ce-u aryl-C i-b alkyl-, C3-i4cycloalkyl-C -6alkyl-, (5-14 membered heteroaryi)-Ci-6alkyl-, and (4-14 membered heterocycloalkyi)~C 1-6 alkyl- of RJare each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R17substituents;Cy!is Ce-w aiyl, Ca-u cycloalkyl, 5-14 membered heteroaryi, or 4-14 membered heterocycloalkyl, wherein the C5-14aryl, C3-!4cycloalkyl, 5- 14 membered heteroaryl, or 4-14 membered heterocycloalkyl is optionally substituted with 1 2, 3, 4, 5, 6 7, or 8 independently selected R substituents;provided that Cy1is not pyridin-4-yl optionally substituted with 1, 2, 3, or 4 independently selected R' substituents;provided that Cy!is not pyrimidm-4-yl optionally substituted with 1, 2, or 3, independently selected RKsubstituents;provided that Cy1is not quinolin-4-yl optionally substituted with 1, 2, 3, 4, 5, or 6 independently selected REsubstituents;Cy2is Cb-14 aryl, C -w cycloalkyl, 5-14 membered heteroaryi, or 4-14 membered heterocycloalkyl, wherein the C5-14aryl, C3-Mcycloalkyl, 5- 14 membered heteroaryi, or 4-14 membered heterocycloalkyl is optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R"substituents;each R31, Rci, Rd!, R82, Rc2, Rd2, R33, R03, and R®is independently selected from H, Gi¬ftalkyl, Ci-6haloalkyl, C2-6 alkenyl, C2-6 alkynyl, Ce-u aryl, C3-i4cycloalkyl, 5-14 membered heteroaryi, 4-14 membered heterocycloalkyl, Ce-w ary l-C -6 alkyl-, C3-14cycloalky I-C1-6alkyl-, (5-14 membered heteroaryl)-Ci-6 alkyl-, and (4-14 membered heterocycloalkylj-Ci-e alkyl-, wherein the Ci-e alkyl, C2-6 alkenyl, C2-6 alkynyl, Gs-14aryl, C3-14cycloalkyl, 5-14 membered heteroaryi, 4-14 membered heterocycloalkyl, Ce-w aryl-Ci alkyl-, C3-H cycloalkyl-Ci-e alkyl-, (5-14 membered heteroaryi)-Ci-s alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6alkyl- of Ra!, Rcl, R®, R3, Rc2, Rd2, R83, R", and Rd’ are each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R° substituents;or, any Rciand Rdlattached to the same N atom, together with the N atom to which they are attached, form a 5- or 6-membered heteroaryi or a 4-14 membered heterocycloalkyl group, wherein the 5- or 6-membered heteroaryi or 4-14 membered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected R&substituents;or any Rc2and Rd2attached to the same N atom, together with the N atom to winch they are attached, form a 5- or 6-membered heteroaryi or a 4-14 membered heterocycloalkyl group, wherein the 5- or 6-membered heteroaryi or 4-14 membered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected R° substituents;or any Rc3and Rd3attached to the same N atom, together with the N atom to which they are attached, form a 5- or 6-membered heteroaryi or a 4-14 membered heterocycloalkylgroup, wherein the 5- or 6-membered heteroary l or 4-14 membered heterocycloalkyl group is optionally substituted with 1 , 2, 3, or 4 independently selected R° substituents;each Rbl, Rb2, and Rb3is independently selected from H, C alkyl, CMhaloalkyl, C2-6 alkenyl, C2-6 alkynyl, C&-14 aryl, C3..14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-u aryl-CMalkyl-, Ci-Hcycloalkyl-CMalkyl-, (5-14 membered heteroaryi)-Ci-6alkyl-, and (4-14 membered heterocycloalkyi)~C 1-6 alkyl-, wherein the C alkyl, C2-6 alkenyl, C2-6 alkynyl, Ci.-u aryd, C3-14 cycloalky 1, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Cs-ir aryl-Ci-e alkyl-, Ch-Mcycioalkyl-CMalkyl-, (5-14 membered heteroaryi)-Ci-6alkyl-, and (4-14 membered heterocycloalky i)-Ci-6alkyl- of RBi, Rb2, and Rb’ are each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R° substituents;each Rel, Re2, and Reis independently selected from H, OH, CN, C1-6 alkyl. CMalkoxy, CMhaloalkyl, Cj-ehaioalkoxy, C2-6 alkenyl, C2-6 alkynyl, Cs-ir aryl, C3-i4cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalk l, Ce-u aryl-CMlkyl-, C3 -14 cycloalkyl-Ci-6alkyl-, (5-14 membered heteroaryl)-Ci-6alkyl-, and (4-14 membered heterocycloalkyl)-Ci.6 alkyl-;each Rg, Rg, Rfi, and Rg3is independently selected from H, CM alkyl. CM alkoxy, C haloalkyl, Ci-ehaloalkoxy, C2-6 alkenyl, C2-6 alkynyl, Ce-u aryd, C3-i4 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-u aryl-C alkyl-, C3. Hcycloalky 1- Cj-e alkyd-, (5-14 membered heteroaryl)-C]-6alkyl-, and (4-14 membered heterocycloalkyl)-Ci- s alkyl-;each RllZ, Rl2, R03, and R1is independently selected from H, CMalkyl. CMhaloalkyl, C2-6 alkeny l, CMalkynyl, Ce-u aryd, C3-i4 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalky 1, Cs-o aryl-CMalkyl-, C3-14 cycloalkyl-CMalkyl-, (5-14 membered heteroaryl)-Ci-6alkyi-, and (4-14 membered heterocycioalkyl)-Ci-6alkyl-;each R·'3, Rk2, RjJ, and Rkis independently selected front OH, CMalkoxy, and CMhaloalkoxy;or any Rj2and RKattached to the same B atom, together wdth the B atom to which they are attached, form a 5- or 6-membered heterocycloalkyl group optionally substituted wdth 1, 2, 3, or 4 substituents independently selected from CMalkyl and CMhaloalkyl;or any RJJand Rb’ attached to the same B atom, together with the B atom to wdtich they are attached, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selec ted from CMalky l and CMhaloalkyl;each Rb, Rc, Rd, Rb, Rf, and R° is independently selected from D, halo, oxo, Ci-e alkyl, Ci-&haloalkyl, C2-6alkenyl, C2-6 alkysiyl, CHaryl, C3-Hcyeloalkyl, 5-14 membered heteroatyl, 4-14 membered heteroeyeloaikyl, Ce-w aiyl-Ci-6 alkyl-, C3-Hcycloalkyl-Ci-e alkyl-, (5-14 membered heteroaryi)-Ci-6 alkyl-, (4-14 membered heterocycloalkyl)-Ci-6 alkyl-, CN, N02, ORa4, SRa4, NHOR34, C(0)Rb4, C(0)NRc4Rd4, C(0)NRc4(0Ra4), C(0)0Ra4, 0C(0)Rb4, 0C(0)NRc4Rd4, NRc4Rd+, \ R; iN k' :Rd :NRc4C(0)Rw, Rc4C(0)0Ra4, NRc4C(0)NRe4Rd4, C(=NRe4)RM, C (=NRe4)NRc4Rd4, NRc4C(=NRe4)NRc4Rd4, NRc4C(=NRe4)Rb4, NRe4S(0)RM, NRc4S(0)NRc4Rd4, NRc4S(0)2Rb4, NRc4S(0)(=NRe4)Rb4, NRc4S(0)2NRcRd4, S(0)Rb4, S(0)NRc4Rd4, S(()j Rh l. S(0)2NRc4Rd4, 0S(0)(===NRe4)Rb4. 0S(0)2Rb4, SF5, P(0)Rf4R84, 0P(0)(0Rn4)(0RI+), P(0)(0RM)(0R14), and BRjRk4, wherein the Ci-6 alkyl, C2-6alkenyl, C2-e alkynyl, Ce- aryl, C3-i4 cyeloalkyl, 5-14 membered heteroaryl, 4-14 memberedheteroeyeloaikyl, CM* aiyrl-C i-b alkyl-, C3-14 cycloalkyl-Cj-e alkyl-, (5- 14 membered heteroaryl)-Ci-6alkyl-, and (4-14 membered heterocycloalkyl)~C 1-6 alkyl- of RB, Rc, RD, R\R\ and R° are each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected RHsubstituents;each Ra4, Rc+, and Rd4is independently selected from H, Ci-&alkyl, Ci-&haloalkyl, C2..e alkenyl, C2-6alkynyl, Ci.-u aryl, C -u cyeloalkyl, 5-14 membered heteroaryl, 4-14 membered heteroeyeloaikyl, Ce-w ary 1-C 1-6 alkyl-, C3-i4 cycloalkyl-Ci-6 alkyl-, (5-14 membered heteroaryl)-Ci-6alkyl-, and (4-14 membered heterocycloalky l)-Ci-6alkyl-, wherein the Ci.&alkyl, C2-e alkenyl, C2-e alkynyl, C6-i4 aryl, C3-i4 cyeloalkyl, 5-14 membered heteroaryd, 4-14 membered heteroeyeloaikyl, CS-Maryl-Cw alkyl-, C3.14 cycloalkyl-Ci-e alkyl-, (5-14 membered heteroaryl)-Ci-6 alkyl-, and (4-14 membered heterocycloalky 1)-Cw alkyl- of Ra4, Rc4, and Rd4are each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R11substituents;or, any Rc4and Rd4attached to the same N atom, together with the N atom to which they are attached, optionally form a 5- or 6-membered heteroaryd or a 4-14 membered heteroeyeloaikyl group, wherein the 5- or 6-membered heteroaryd or 4-14 membered heteroeyeloaikyl group is optionally substituted with 1, 2, 3, or 4 independently selected Rdsubstituents;each Rb4is independently selected from H, Cue alkyl. Cue haloalkyl, C2-6alkenyl, C2-&alkynyl, C&-14 aryl,€3-14 cyeloalkyl, 5-14 membered heteroaryl, 4-14 memberedheteroeyeloaikyl, CM* aryl-C i-b alkyl-, C3-i4 cycloalkyl-Ci-6 alkyl-, (5-14 membered heteroaryl)-Ci-6alkyl-, and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-, wherein the Ci-s alkyl, C2-6alkenyl, C2-6 alkyny l, Ci.-u aryl, C -u cyeloalkyl, 5-14 membered heteroaryd, 4-14membered heterocycloalkyl, Cs-ir aiyl-Cw alkyl-, Ci-u cycloalkyl-Cw alky' 1-, (5-14 membered heteroaryl)-C]-6 alkyl-, and (4-14 membered heterocycloa3kyl)-Ci-6 alkyl- of RB4are each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected Rrisubstituents; each Re4is independently selected from H, OH, CN, Cw alkyl, Cw alkoxy, Ci-6haloalkyl, Cwhaloalkoxy, C2-6 alkenyl, C2-6 alkynyl, Ca-u aryl, C3-i4 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-ir aiyl-Ci-6alkyl-, Cs-u cycloalkyi- Cw alkyl-, (5-14 membered heteroaryl) -C -6alkyl-, and (4-14 membered heterocycioalkyl)-C -6alkyl-;each Rf4and R8* is independently selected from H, Cm, alkyl, Cwalkoxy, Ci-6haloalkyl, Cwhaloalkoxy, C2-6 alkenyl, C2-6 alkynyl, CKaryl, C3-i4 cycloalkyl, 5-14 membered heteroary l, 4-14 membered heterocycloalkyl, CM4 ary' i-C 1-6 alkyl-, C3-i4 cycloalky 1- C -6alkyl-, (5-14 membered heteroaryli-Ci-f, alkyl-, and (4-14 membered heterocycloaikyli-Ci-6alkyl-;each Rh4and Rl4is independently selected from H, Ci.&alkyl, Ci.&haloalkyl, C2-6 alkenyl, C2-6 alkynyl, Ce-w aryl, Cj-w cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce- aryl-C 1.5 alkyl-, Cs-u cycloa kyl-Ci-e alkyl-, (5-14 membered heteroaryl)-Ci-6 alkyl-, and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;each Rj4and R“4is independently selected from OH, Cwalkoxy, and Cwhaloalkoxy; or, any R|4and Rk4attached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-mem bered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from Cw alkyl and Ci-6haloalkyl;each RHis independently selected from D, halo, oxo, Cw alkyl, Cw haloalkyl, C2-6 alkenyl, C2-6 alkynyl, Ce-u aryl, C3-u cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-w ary l-Cw alkyl-, C3-14cycloalkyl-Cw alkyl-, (5-14 membered heteroaryl)-Cw alkyl-, (4-14 membered heterocy oalky -Cw alkyl-, CN, NO2, OR35, SRa5, NHORa5, C(0)Rb5, C(0)NRc5Rd5, C(0)NRc5(0Ra5), C(0)0R35, 0C(0)Rbs, 0C(0)NRc5Rd5. NRc5Rd5, NRc5NRc5Rd5,NRc5C(0)Rbs, NRc5C(0)0R35, NRc5C(0)NRc5Rd5, C(=NReS)Rb5, C(=NRe5)NRc5Rd5, NRc5C(=NRe5)NRc5Rd5, NRc5C(=NRe5)Rb5, NRc5S(0)Rb5,NRc5S(0)NRc5Rd5, N R-'SiOyR1". NRc5S(0)(-NRc5)Rb5, NRc5S(0)2NRc5Rd5, S(0)Rb5, S(0)NRc5Rd5, S(0) .R!"'. S(0)2NRc5Rd5, 0S(0)(=NRe5)Rb5, 0S(0)2Rbs, SFs, P(0)RfiRgi, 0P(0)(0Rh5)(0Rl5), P(0)(0Ra5)(0R5), and BRj5Rk:, wherein the Cw alkyl, C2-6alkenyl, C2-6 alkynyl, Ca-u aryl, C3-i4 cycloalkyl, 5-14 membered heteroaryl, 4-14 memberedheterocycloalkyl, Ce-ir aiyl-Ci-6 alkyl-, Cs-u cycloalkyi-Ci-e alkyl-, (5-14 memberedheteroaryl)-C]-6 alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6alkyl- of Rflare each optionally substituted with 1 , 2, 3, or 4 independently selected R* substituents;each Ra5, Rc5, and Rd5is independently selected from H, C i-s alkyl, Ci-s haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C&-14 aryl, C3..14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-u aryd-C i-e alkyl-, C3-i4 cycloalkyl-Ci-6 alkyl-, (5-14 membered heteroaryl)-Ci-6alkyl-, and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-, wherein the Ci-s alkyl, C2-6alkenyl, C2-6alkynyl, Ci.-u aryl, CJ-Mcycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-u aryl-Ci-e alkyl-,€3-54 cycloalkyl-Cj-6 alky' 1-, (5-14 membered heteroaryi)-Ci-6alkyl-, and (4-14 membered heterocycloalky i)-C 1.6 alkyl- of Ra5, Rc>, and Rdsare each optionally substituted with 1, 2, 3, or 4 independently selected R1substituents;or any R05and Rdaattached to the same N atom, together with the N atom to winch they are attached, form a 5- or 6-membered heteroary l or a 4-14 membered heterocycloalkyl group, wirerein the 5- or 6-membered heteroaryl or 4-14 membered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected R!substituents;each Rtois independently selected from H, Cj-6alkyl, Cj-6haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C&.14 aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 memberedheterocycloalkyl, C w ary I-C1-&alkyl-, C3-14 cycloalkyl-Ci-e alkyl-, (5-14 membered heteroaryl)-C]-6alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6 alkyl-, wirerein the Cj-e alkyl, C2-6 alkenyl, C2-6 alkynyl, C&.14 aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Cs-w aryl-Ci-e alkyl-, CVw cycloalkyl-Ci-e alkyl-, (5-14 membered heteroaryl)-Ci-6alkyl-, and (4-14 membered heterocycloalkyl)-C½alkyl- of Rb5are each optionally substituted with 1 , 2, 3, or 4 independently selected R1substituents;each Re5is independently selected from H, OH, CN, Ci-e alkyl, Ci-e alkoxy, Ci-e haloalkyl, Ci-ehaioalkoxy, C2-6 alkenyl,€2-5 alkynyl, CG-Maryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-u axyl-Ci-e alkyl-, Cj-w cycloalkyl- Ci-dalkyl-, (5-14 membered heteroaryi)-Ci-6 alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6alky 1-;each Rf5and R85is independently selected from H, Ci-e alkyl Ci-ealkoxy, Ci-e haloalkyl, Ci-ehaloalkoxy, C2-6 alkeny l, Ci-t, alkynyl, Ce-w aiyl, C3-Wcycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ob- aryl-Cj-6alkyl-, Cs-w cycloalkyi- Ci-6alkyl-, (5-14 membered heteroaryl) -Ci-6alkyl-, and (4-14 membered heterocycloaikyl)-Ci-&alkyi-;each R115and R15is independently selected from H, Cj-e alkyl, Cj-b haloalkyl, C2-6 alkenyl, C2-6alkynyl, C&-J4 aryl, C3-14cycloalkyl, 5-14 membered heteroaryl, 4-14 memberedheterocycloalkyl, Ce-w ary i-Ci-6 alkyl-, C -i+cycloalkyl-C -e alkyl-, (5-14 membered heteroaryl)-C]^ alkyl-, and (4-14 membered heterocycloa3kyl)-Ci-6 alkyl-;each RJiand R’° is independently selected from OH, C -salkoxy, and Ci-ehaloalkoxy; or, any Rjdand Rk5attached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from Ci-e alky l and Ci-6haloalkyl;each Rlis independently selected from D, halo, oxo, Ci-e alkyl, Ci-e haloalkyl, C2-6 alkenyl, C2-6 a!kynyl, Ce-u aryl, Caur cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce- aryl-C 1-5 alkyl-, Cs-u cycloalkyl-Ci-e alkyl-, (5-14 memberedheteroaryl)-C 1-6 alkyl-, and (4-14 membered heteroeyeloalkyi)-Ci-s alkyl-, CN, N02, OKa5, SR36, NHORa6, C(0)Rb6, C(0)NRc6Rd6, C(0)NRc6(0Ra6), C(0)ORa6, OC(0)Rb6,OC (Q)NRc6Rd6, \ R:R!:\ NRc6NRc6Rd6, NRc6C(0)Rb6, NRc6C(0)0Ra6, NRc6C(0)NRc5Rd6, C(=NRe6)Rb6, C(=NRe6)NRc6Rd6, NRc6C(=NRe6)NRc6Rd6, NRc6C(=NRe6)Rb6, NRc6S(0)Rb6, NRc6S(G)NRc6Rd6, NRc6S(0)2Rb5, NRc6S(0)(===NRi:6)Rb6, NRc6S(0)2NRc6Rd6, S(0)Rb6,S(0)NRc6Rd6, S(0)2Rb6, S(0)2NRc6Rd6, 0S(0)(=NRe6)Rb6, 0S(0)2Rb6, St·,. P(0)Ri6Rg6, 0P(0)(0Rh5)(0Rl6), P(0)(0Rb6)(0R16), and BRj6Rt6, wherein the C;,·. alkyl, ('·,·. alkenyl, C2.5alkynyl, Ci.-n aryl, CB-Mcycloalkyl, 5-14 membered heteroaryl, 4-14 memberedheterocycloalkyl, Ce-w ary i-Ci-6alkyl-, Ca-i+cycloalkyl-C -e alkyl-, (5-14 memberedheteroaryi)-Ci-6alkyl-, and (4-14 membered heterocycloalky i)-C 1.6 alkyl- of R1are each optionally substituted with 1, 2, 3, or 4 independently selected RJsubstituents;each Ra6, Rcf>, and Rd6is independently selected from H, Ci-6alkyl, Ci-6haloalkyl, C2.6alkenyl, C2-&alkynyl, Ce-w aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-ir aryl-Ci-6 alkyl-, Cs-u cycloalkyl-Ci-e alkyl-, (5-14 memberedheteroaryl)-Ci-6alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6alkyl-, wherein the Che alkyl, C2-&alkenyl, C2-&alkynyl, CMaryl, Ci-Kcycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Cs-w aryl-Ci^ alkyl-, C3-14 cycloalky l-Ci-6 alkyl-, (5-14 membered heteroaryl)-Ci^ alkyl-, and (4-14 membered heterocycloalkyl)-C ue alkyl- of Rao, Rc6, and Rd6are each optionally substituted with 1, 2, 3, or 4 independently selected RJsubstituents; or any RCRand Rd6attached to the same N atom, together with the N atom to which they are attached, form a 5- or 6-membered heteroaryl or a 4-14 membered heterocycloalkyl group, wherein the 5- or 6-membered heteroaryl or 4-14 membered heterocycloalkyl group is optionally substituted with 1 , 2, 3, or 4 independently selected R1substituents;each Rb6is independently selected from H, Ci-6alkyl, Cue haloalkyl, C2-6alkenyl, C2-6 alkynyl, C&-J4 aryl, CB-Mcycloalkyl, 5-14 membered heteroaryl, 4-14 memberedheterocycloalkyl, 65-14ary 1-6 i-e alkyl-, C -i+cycloalkyl-C -e alkyl-, (5-14 membered heteroaryl)-C]^ alkyl-, and (4-14 membered heterocycloa3kyl)-Ci-6alkyl-, wherein the C -6aikyi, alkenyl, C2-6alkyny!,5-14aryl,€3-14cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, 65-14ar l-Cw alkyl-, C3-14cycloalkyl-Ci-e alkyl-, (5-14 membered heteroaryl)-Ci-6aikyl-, and (4-14 membered heterocycloalkyl)-C]-6aikyi- of Rb6are each optionally substituted with 1, 2, 3, or 4 independently selected RJsubstituents;each Re6is independently selected from H, OH, CN, Ci-e alkyl, Ci-e alkoxy, Ci-&haloalkyl, Ci-ehaioalkoxy', 62-5alkenyl, C2-6alkynyl, 65-14aryl, C3-14cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, 65-14aryl-61-5aikyi-, C3-14cycloalky 1- 61-5 alkyl-, (5-14 membered heteroaryl)-C]-6 alkyl-, and (4-14 membered heterocycloalkyl)-C]-6alkyl-;each Rf6and Rg6is independently selected from H, Ci-e alkyl, Ci-e alkoxy, Ci-&haloalkyl, C -ehaloalkoxy, C2-6alkenyl, 62-5alkynyl, 65-14aryi, 63-14cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, 65-14ary l-Ci-6alkyl-, C3..14cycloalky 1- C i-6 alkyl-, (5-14 membered heteroaryl)-6i-s alkyl-, and (4-14 membered heterocycloalkyl)-C i-6alkyl-;each Rh6and Rl6is independently selected from H, C -6alkyl, 61-5haloalkyl, C2-6alkenyl, C2-6alkynyl, 65-14aryl, 63-14cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, 5-1aryl-61.5alkyl-, C3-14cycloalky l-Ci-6 alkyl-, (5-14 membered heteroarvd)-C1-6alkyl-, and (4-14 membered heteroeyeloalkyl)-Ci-s alkyl-;each RJf>and R*6is independently selected from OH, Ci-ealkoxy, and Ci-ehaloalkoxy; or, any Rj6and Rkbattached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-membered heterocycloalky 1 group optionally substituted with 1, 2, 3, or 4 substituents independently selected from 61-5alkyl and Ci-6haloalky l;each RJis independently selected from D, halo, oxo, Ci-6alkyl, 61-5haloalkyl, C2-6 alkenyl, C2-6 alkynyl, 65.14aryd, 63-1cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, 5-14 ar l-Cw alkyl-, C3-14 cycloalkyl-Ci-e alkyl-, (5-14 memberedheteroaryl)-6]-6 alkyl-, and (4-14 membered heterocycloalkyl)-6i-6 alkyl-, 6N, N(¾, ORa / , SRa?, NHOR87, 6(0)Rb7, C(0)NRc7Rd7, 6(0)NRc7(0Ra7), C(0)0R*7, 06(0)Rb7,0C(0)NRc7Rd7, NRc7Rd7, NRc7NRc7Rd7,NRc76(0)Rb7, NRc7C(0)0Ra7, NRc76(0)NRc7Rd7, C(=NRe7)Rb7, 6(=NRc7)NRc7Rd7, NRc76(===NRe7)NRc7Rd?, NRc76(===NRe7)Rb7, NRc7S(0)Rfc7, NRc7S(0)NRc7Rd7, NRc7S(0>2Rb7, NRc7S(0)(=NRe7)Rb7, NRc7S(0)2NRc7Rd7, S(0)Rb7, S(0)NRc7Rd7, S(0)2Rh7, S(0)2NRc7Rd?, 0S(0)(=NRe7)Rb7, 0S(0)2Rb75SFs, P(())K Rf . 0P(0)(0Rh7)(0Ri7), P(0)(0Rh7)(0R’7), and BR%k7, wherein the CMalkyl, 62,5alkenyl, 62,5alkynyl, Ce- aryl, C3-i4 cycloalkyl, 5-14 membered heteroaryl, 4-14 memberedheterocycloalkyl, CM* aiyl-Ci-e alkyl-, C3-14 cycloalkyl-Cj-e alkyl-, (5-14 membered heteroaryl)-C 1-6 alkyl-, and (4-14 membered heteroeycloalkyl)-Ci-s alkyl- of RJare each optionally substituted with 1, 2, 3, or 4 independently selected RKsubstituents;each Ra7, Rc7, and Rdis independently selected from H, Cj-6alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6alkynyl, Ce-u aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, CM* ar I-C1-& alkyl-, C3-14 cycloalkyl-Cw alkyl-, (5-14 membered heteroaryl)-C]-6 alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6 alkyl- wherein the C1-6 alkyl, C2-&alkenyl, C2« alkynyl, Ce-u aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C w ary l-Ch-s alkyl-, C3-i4 cycloatkyl-C] -6 alkyl-, (5-14 membered heteroaryl)-C]-6 alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6 alkyl- of Ra', Rc / , and Rd?are each optionally substituted with 1, 2, 3, or 4 independently selected R substituents; or any Rc / and Rd7attached to the same N atom, together with the N atom to which they are attached, form a 5- or 6-membered heteroaryl or a 4-14 membered heterocycloalkyl group, wherein the 5- or 6-membered heteroaryl or 4-14 membered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected RKsubstituents;each Rb7is independently selected from H, Ci-e alkyl, Ci-e haloalkyl, C2-6 alkenyl, C2-6alkynyl, Ce- aryd, C3-i4 cycloalkyl, 5-14 membered heteroaryl, 4-14 memberedheterocycloalkyl, Ce- aryl-C 1.5 alkyl-, C3-14 cycloalky l-Ci-6 alkyl-, (5-14 membered heteroaryd)-C 1-6 alkyl-, and (4-14 membered heterocycloalkylVC i-s alkyl-, wherein the Ci-s alkyl, C2- s alkenyl, C2-s alkynyl, C&-14 aryd, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Cg-w aryl-Ci-e alkyl-, C3-u cycloalk l-Ci-d alkyl-, (5-14 membered heteroaryl)-Ci-6alkyl-, and (4-14 membered heterocycloalkyl)-C 1-6 alkyl- of R0 / are each optionally substituted with 1, 2, 3, or 4 independently selected RKsubstituents;each Rs' is independently selected from H, OH, CN, Ci-e alkyl, C2-6 alkenyl, C 1-6 alkoxy, Ci.&haloalkyl, Cj-shaloalkoxy, C2-e alkynyl, Ce-ir aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, and 4-14 membered heterocycloalkyl;each Rf?and Rg / is independently selected from H, Ci-e alkyl, Cue alkoxy, Ci-e haloalkyl, C;i-f!haloalkoxy, C2-6alkeny l, C2-&alkynyl, Ce-w aiyl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl,€b- aryl-Cj-6alkyl-, Cs-w cycloalkji- Ci-6alkyl-, (5-14 membered heteroaryl) -C1-6 alkyl-, and (4-14 membered heterocycloalky 1)-Ci.&alkyd-;each Rh?and R1' is independently selected from H, Ci-g alkyl, Cj^ haloalkyl, C2-6alkenyl, C2-e alkynyl, C&-J4 aryd, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 memberedJ2heterocycloalkyl, Ce-w ary 1-C 1-6 alkyl-, Cj-i+cycloalkyl-Cj-e alkyl-, (5-14 membered heteroaryl)-C]-6 alkyl-, and (4-14 membered heterocycloalky 1)-Cw alkyl-;each Rj7and Rk' is independently selected from OH, Cj-salkoxy, and Ci-shaloalkoxy; or, any Rj' and Rk / attached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from Ci-e alkyl and Ci-e haloalkyl;each R is independently selected from H, D, OH, halo, oxo, CN, C(0)0H, NH2, NO2, SFs, Cj-6alkyl, Cj-e alkoxy, Ci-ehaloalkoxy, Cj-e haloalkyl, C2-6 alkenyl, C2-e alkynyl, Ce¬laryl, CB-Mcycloalkyl, 5-14 membered heteroaryi, 4-14 membered heterocycloalky 1, Ce-u aryl-Ci-6alkyl-, CVw cyctoalkyl-Ci-e alkyl-, (5-14 membered heteroaryi)-Ci-6alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6alkyl-; andwherein any heteroaryl group of any of the above-recited substituents optionally comprises an N-oxide on any ring-forming nitrogen.In some embodiments,X is CR3;R!is selected from H, Ci-b alkyl, C2-6 alkenyl, C2-6 alkynyl, and Ci-b haloalkyl;R2is selected from H, D, halo, Cj-6alkyl, Cj-6haloalkyl, C2.-6 alkenyl, C2-6 alkynyl, CV i4 aryl, Cs-w cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, CX-Maryl-Ci-6alkyl-, Cs-u cycloalky l-Ci-6alkyl-, (5-14 membered heteroaryl)-Ci-6alkyl-, (4-14 membered heterocycloalkyl)-C !-e alkyl-, CN, N<¾, OR82, SR32, NHOR32, C(0)Rb2,C(0)NRc2Rd2, C(0)NRc2(0Ra2), C(0)0Ra2, 0C(0)Rb2, 0C(0)NRc2Rd2, NRc2Rd2,NRc2NRc2Rd2, NRc2C(0)Rb2, NRc2C(0)0Ra2, NRc2C(0)NRc2Rd2, C(=NRe2)Rb2,C(=NRe3)NRc2Rd2, NRc3C(=NRe2)NRc2Rd2, NRc2C(=NRe2)Rb2, NRc2S(0)NRc2Rd2,NRc2S(0)Rb2, N R S;()i RK'. NRc2S(0)(=NRe2)Rb2, NRc2S(0)2NRc2Rd2, S(0)Rb2,S(0)NRc2Rd2, S(0)2Rb2, S(0)2NRc2Rd2, 0S(0)(=NRe2)Rb2, 0S(0)2Rb2, Si·',. P(0)Ri2Rg2, 0P(0)(0Ril2)(0R2), P(0)(0Rb2)(0Rl2), and BRj2Rk2, wherein the C;,·. alkyl, ('·,·. alkenyl, ('·,·. alkynyl, Ct,-u aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 memberedheterocycloalkyl, Ce-w aryl-Ci-6 alkyl-, Cj-i+cycloalkyl-Cj-e alkyl-, (5-14 membered heteroaryl)-C]-6 alkyl-, and (4-14 membered heterocycloalky 1)-Cw alkyl- of R·are each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R substituents;R3is selected from H, D, halo, Ci.&alkyl, Ci.&haloalkyl, C2-6 alkenyl, C2-6 alkynyl, Ce- i4aiyl,€3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, CV14 aryl-Ci-6alkyl-, CS-Hcycloalky l-C 1-6 alkyl-, (5-14 membered heteroaryl)~Ci-6alkyl-, (4-14 membered heterocy cloalkyl)-C 1-6 alkyl-, CN, N02,ORa3, SRa3, NHORa3, C(0)Rb3,0P(0)(0Rh3)(0Rl3), P(0)(0Rb3)(0Rl3), and BRj3Rk3. wherein the Ci-e alkyl, C2-6alkenyl, C2-6alkynyl, Ci.-n aryl, CB-Ucycloalkyl, 5-14 membered heteroaryl, 4-14 memberedheterocycloalkyl, Ce-w ary l-Ci-6alkyl-, C -i+cycloalkyl-C -e alkyl-, (5-14 membered heteroaryi)-Ci-6alkyl-, and (4-14 membered heterocycloalky i)-Ci-6alkyl- of R3are each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R13substituents;Cy!is Ce-w aryl, C -u cycloalkyl, 5-14 membered heteroaryl, or 4-14 membered heterocycloalkyl, wherein the C5-14aryl, C3-! 4cycloalkyl, 5-14 membered heteroaryl, or 4-14 membered heterocycloalkyl is optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R or RMsubstituents;Cy2is Ce-w aryl, CB-Mcycloalkyl, 5-14 membered heteroaryl, or 4-14 membered heterocycloalkyl, wherein the Ce-w aryl, C3-i4cycloalkyl, 5-14 membered heteroaryl, or 4-14 membered heterocycloalkyl is optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected Rrsubstituents;each R3i, Rc\ Rd2, RaJ, Rc3, and Rd3is independently selected from H, C .6alkyl, C .6haloalkyl, C2-6 alkenyl, C2-6alkynyl, Cs-n aryl, Cs-wcycloalkyl, 5-14 membered heteroaryl, 4- 14 membered heterocycloalkyl, C<5-i4ary l-Ci-6 alkyl-, C3-14cycloalky 1-Cw alkyl-, (5-14 membered he ternary l)-Ci-&alkyl-, and (4-14 membered heterocycloalkyl)-Cw alkyl-, wherein the C -6alkyl, C2-g alkenyl, C2-6alkynyl, Ce-u aryl, C3-i4cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C&.14ary l-Ci-6 alkyl-, C3-14cycloalky 1-Cw alkyl-, (5-14 membered heteroaryl) -Cs-6 alkyl-, and (4-14 membered heteroeyeloalkyi)~Cs-6 alkyl- of R®2, Rc2, Rd2, RaJ, R°3, and Rd3are each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R&substituents;or any Rc2and Rd2attached to the same N atom, together with the N atom to which they are attached, form a 5- or 6-membered heteroary l or a 4-14 membered heterocycloalkyl group, wherein the 5- or 6-membered heteroaryl or 4-14 membered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected R° substituents;or any Rc3and Rd3attached to the same N atom, together with the N atom to which they are attached, form a 5- or 6-membered heteroaryl or a 4-14 membered heterocycloalkylgroup, wherein the 5- or 6-membered heteroary l or 4-14 membered heterocycloalkyl group is optionally substituted with 1 , 2, 3, or 4 independently selected R° substituents;each Rfc2and Rb3is independently selected from H, Ci-e alkyl, Ci-e haloalkyl, C2-6alkenyl, C2-6 alkynyl, C&-14 aryl, C3..14 cycloalkyl, 5-14 membered heteroaryi, 4-14 membered heterocycloalkyl, Ce-u aryl-C i-e alkyl-, C3-i4cycloalkyl-Ci-6 alkyl-, (5-14 membered heteroaryi)-Ci-6alkyl-, and (4-14 membered heterocycloalkyi)~C 1-6 alkyl-, wherein the Ci-s alkyl, C2-6 alkenyl, C2-6 alkynyl, Ci.-u aryd, C3-14 cycloalky 1, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-u aryl-Ci-e alkyl-, Cs-u cycloalkyl-Cj-e alkyl-, (5-14 membered heteroaryi)-Ci-6alkyl-, and (4-14 membered heterocycloalky i)-C 1.6 alkyl- of RB2and Rb’ are each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R° substituents; each R” and ReJis independently selected from H, OH, CN, CMalkyl, Ci^alkoxy,C i-b haloalkyl, C;i-f!haloa3koxy, C2-6 alkeny l, C2-6 alkynyl, Ce-w aryl, C3-Mcycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-i4 aryl-Ci-6alkyl-, C3-14 cycloalky 1- Ci-6alkyl-, (5-14 membered heteroaryl) -C1-6 alkyl-, and (4-14 membered heterocycloalky 1)-Ci.&alkyd-;each Rf2, Rg3, Rf3, and Rg3is independently selected from H, Ci-b alkyl, Ci-e alkoxy, Ci-f.haloalkyl, Cj-ehaloalkoxy, C2-6 alkenyl, C2-6 alkynyl, C&-J4 aryl, Cs-u cycloalkyl, 5-14 membered heteroary l, 4-14 membered heterocycloalkyl, CM4 ary l-Ci-6alkyl-, C3-14 cycloalky 1- Ci-dalkyl-, (5-14 membered heteroaiyi)-Ci-6alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6alkyl-;each Rh2, R12, R“3, and Rl3is independently selected from H, Ci.&alkyl, Ci-ehaloalkyl, C2-6 alkenyl, C2-6 alkynyl, C&-J4 aryd, C3-14 cycloalkyl, 5-14 membered heteroary l, 4-14 membered heterocycloalkyl, Ce-u aryl-Cj-e alkyl-, C3-14 cycloalky 1-Cw alkyl-, (5-14 membered heteroaryl)-Ci.6 alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6 alkyl-;each Rj2, Rk2, R , and RK3is independently selected from OH, Ci-e alkoxy, and Ci-6haloalkoxy;or any R|2and RKattached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from Ci-e alkyl and Ci-eha!oalky!;or any Rj3and R^3attached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1 , 2, 3, or 4 substituents independently selected from C -.-e alkyd and Ci-shaloalkyl;each Rc, RD, Rb, RM, Rf', and R° is independently selected from D, halo, oxo, C1-6 alkyl, Ci-e haloalkyl, C3-6 alkenyl, C2-6 alkynyl, CM* aryl, C3-14 cycloalky 1, 5-14 memberedheteroaryl, 4-14 membered heterocycloalkyl, C&.J4ary l-Ci-6 alkyl-, Cs-ir cycloalkyl-Ci-e alkyl-, (5-14 membered heteroaryl) -Ci ..6alkyl-, (4-14 membered heterocycloalkyl)-Ci^, alkyl-, CN,0P(0)(0RM)(0R14), P(0)(0RM)(0Ri4), and BR¾k4, wherein the Ci-6alkyl C2-6alkenyl C2-6alkynyl, C&.14aryl, C3-14cycloalkyl, 5-14 membered heteroaryl, 4-14 memberedheterocycloalkyl, Ce-i4 aryl-C -6 alkyl-, Cs-w eyeloalkyi-Ci-e alkyl-, (5-14 membered heteroaryl)-C]-6 alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6alkyl- of Rc, RD, R“, RM, Rr, and R° are each optionally substituted with 1 , 2, 3, 4, 5, 6, 7, or 8 independently selected Rrisubstituents;each Ra4, Rc4, and Rd4is independently selected from H, Ci-6alkyl, Ci-6haloalkyl, C2.6alkenyl, C2-6alkynyl, Ce-u aryl, Cj-w cycloalkyl 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-u aryl-C 1.5 alkyl-, C3-14 cycloalky l-Ci-6 alkyl-, (5-14 membered heteroaryd)-Ci-6 alky!-, and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-, wherein the Ci-6 alkyl, C2-6alkenyl, C2-6alkynyl, Ce-u aiyi, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-u aryl-Ci-6alkyl-, C3-14 cycloalky l-Ci-6 alkyl-, (5-14 membered heteroaryl)-C 1-6 alkyl-, and (4-14 membered heteroeyeloalkyl)-C i-s alkyl- of Ra4, Rc4, and Rd4are each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R;tlsubstituents;or, any Rc4and Ra4attached to the same N atom, together with the N atom to which they are attached, optionally form a 5- or 6-membered heteroaryl or a 4-14 membered heterocycloalkyl group, -wherein the 5- or 6-membered heteroaryl or 4-14 membered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected RHsubstituents;each Rwis independently selected from H, Ci-6 alkyl, Ci-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, Ce-u aryl, C3-Wcycloalkyl, 5-14 membered heteroaryl 4-14 memberedheterocycloalkyl, C6-i4 aryl-C -6alkyl-, Cs-w cycloalkyi-Ci-e alkyl-, (5-14 membered heteroaryl)-Ci-6alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6alkyl-, -wherein the Ci-6alkyl, C2-&alkenyl, C2-&alkynyl, C u aryl, Ci-u cycloalkyl, 5-14 membered heteroaryl 4-14 membered heterocycloalkyl, Ce-u aryl-Ci-e alkyl-, Cs-u cycloalky l-Ci-6 alkyl-, (5-14 memberedheteroaryl)-C]-6 alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6 alkyl- of Rb4are each optionally substituted with 1 , 2, 3, 4, 5, 6, 7, or 8 independently selected Rrisubstituents; each Re4is independently selected from H, OH, CN, Ci-6 alkyl, Ci-e alkoxy, Cs-6 haloalkyl, Ci-ehaloalkoxy, C2-6 alkenyl,€2-5 alkynyl, C&-1 aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-u axyl-Ci-e alkyl-, C3-14 cycloalkyl- Ci-6alkyl-, (5-14 membered heteroaiyll-Ci-g alkyl-, and (4-14 membered heterocycloalkyl)-Cs-6alkyl-;each Rf4and Rg4is independently selected from H, Ci-e alkyl Ci-e alkoxy, Ci-e haloalkyl, Ci-ehaloalkoxy, C2-6 alkenyl, C2-6alkynyl, Cl-ir aiyl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-i4 aryl-Cj-6alkyl-, Cs-sr cyeloalkyi- C 1-6 alkyl-, (5-14 membered heteroaiy l)-Ci-6alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6alkyl-;each Rh4and Rl4is independently selected from H, Cj-e alkyl, Cs-g haloalkyl, C2-6 alkenyl, Cz-s alkynyl, C&-14 aryl, C3..14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-u aryl-C i-e alkyl-, Cl-Hcyeloalkyl-Cs-e alkyl-, (5-14 membered heteroaryl)-Ci-6alkyl-, and (4-14 membered heterocycloalky l)-C 1.6 alkyl-;each RJ4and R“4is independently selected from OH, Cj-ealkoxy, and Ci-ehaloalkoxy; or, any Rj4and Rk+attached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-membered heterocycloalky 1 group optionally substituted with 1, 2, 3, or 4 substituents independently selected from Cs-6alkyl and Cs-6haloalkyl;each RHis independently selected from D, halo, oxo, Ci-6alkyl, Ci-6haloalkyl, C2-6 alkenyl,€2-6 alkynyl, Ce-w aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-ir aryl-Ci-g alkyl-, Cs-u cycloalkyi-Ci-e alkyl-, (5-14 membered heteroaiyl)-Ci-6 alkyl-, (4-14 membered heterocycloalkyl)-Ci-6 alkyl-, CN, NO2, OR85, SR3', NHOR35. C(0)Rb5, C(0)NRc:~’Rd5, C(0)NRc5(0Ra5), C(0)0Ra5, 0C(0)Rb5, 0C(0)NRc5Rd5, NRc5Rd5, NRc5NRc5Rd5,NRc5C(0)Rb5, NRc5C(0)0R3?', NRc5C(G)NRc5Rd5, C(===NRe5)Rh5, C(=NRe5)NRc5Rd5, NRc5C(=NRe5)NRc5Rd5, NRcSC(=NReS)Rbs, NRc5S(0)RM,NRc5S(0)NRc5Rd5, NRc5S(0)2Rh5, NRc5S(0)(=NRe5)Rb5, NRc5S(0)2NRc5Rd5, S(0)Rb5,SiOiN R R4 '. S(0)2Rb5, S(0)2NRc5Rd5, 0S(0)(=NRe5)Rb5, 0S(0)2Rb5, SFs, P(0)RcR85, OP QXOR^XQR15), P(0)(0R!r!)(0Ri:), and BRj5Rk5, wherein the Ci-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, Cg-u aryl,€3-14 cycloalky 1, 5-14 membered heteroaryl, 4-14 memberedheterocycloalkyl, Ce-u aryl-C i-e alkyl-,€3-14 cycloalkyl-Ci-6 alkyl-, (5-14 membered heteroaryl)-Ci-6alkyl-, and (4-14 membered heterocycloalkyl)-C 1-6 alkyl- of R1 !are each optionally substituted with 1, 2, 3, or 4 independently selected R!substituents;each Ra\ Rc5, and Rd>is independently selected from H, Ci-e alkyl, Ci-e haloalkyi, C2-6 alkenyl, C2-6 alkynyl, Ce-w aryl, C3-14 cycloalkyl, 5-14 membered heteroaryi, 4-14 membered heterocycloalkyl, Ce-i4 aryt-C -6 alkyl-, Cs-Mcyeloalkyl-Ci-e alkyl-, (5-14 membered heteroaryl)-Ci.6alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6alkyl-, wherein the Ci-e alkyl, C2-6 alkenyl, C2-6 alkynyl, CV14 aryl, C3-i4 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-u aryi-C -e alkyl-, CS-Mcycloalky l-Ci-6 alkyl-, (5-14 membered heteroaryl)-Ci-6alkyl-, and (4-14 membered heterocycloalkyl)-C ue alkyl- of R3>, Rc5, and Rd5are each optionally substituted with 1, 2, 3, or 4 independently selected R1substituents;or any RcSand Rd5attached to the same N atom, together with the N atom to which they are attached, form a 5- or 6-membered heteroaryl or a 4-14 membered heterocycloalkyl group, wherein the 5- or 6-membered heteroaryi or 4-14 membered heterocycloalkyl group is optionally substituted with 1 , 2, 3, or 4 independently selected R1substituents;each Rb5is independently selected from H, Ci-e alkyl, Cue haloalkyi, C2-6 alkenyl, C2-6 alkynyl, C&-14 aryl, C3-14 cycloalky 1, 5-14 membered heteroaryl, 4-14 memberedheterocycloalkyl, Ce-u aryl-Ci-e alkyl-, C3-i4eyeloalkyl-C -6alkyl-, (5-14 membered heteroaryl)-Ci-6alkyl-, and (4-14 membered heterocycloalky 1)-C 1.6 alkyl-, wherein the Ci.&alkyl, C2-6 alkenyl, C2-6 alkynyl, Ci.-u aryl, CJ-Mcycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-u aryl-Ci-e alkyl-,€3-54 cycloalkyl-C -6 alky' 1-, (5-14 membered heteroaryl)-Ci-6alkyl-, and (4-14 membered heterocycloalky 1)-C 1.6 alkyl- of R”3are each optionally substituted with 1, 2, 3, or 4 independently selected R1substituents;each Rs5is independently selected from H, OH, CN, C.-s alkyl, C.-s alkoxy, Ci-6haloalkyi, Ci-ehaloalkoxy, C2-6 alkeny l, C2-6 alkynyl, Ce-w aiyl, C3-Hcycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-ir aiyl-Ci-6alkyl-, C3-14 cycloalkyl- Ci-6alkyl-, (5-14 membered heteroaryl) -C1-6 alkyl-, and (4-14 membered heterocycloalky 1)-Ci.&alkyd-;each Rband Rg5is independently selected from H, Cm, alkyl, Ci«alkoxy, Ci-e haloalkyi, C -ehaloalkoxy, C2-6 alkenyl, C2-6 alkynyl, Ci.-n aryl, C3-14 cycloalky 1, 5-14 membered heteroaryi, 4-14 membered heterocycloalkyl, CM4 ary l-Ci-6alkyl-, C3-14 cycloalky 1- C [-6alkyl-, (5-14 membered heteroaryi) -Ci-g alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6alkyl-;each RtDand R15is independently selected from H, Ci.&alkyl, Ci.&haloalkyi, C2-6 alkenyl, C2-6 alkynyl, Ce-w aryl,€3-14 cycloalkyl, 5-14 membered heteroaryi, 4-14 membered heterocycloalkyl, Ce-i aiyi-Ci-6 alkyl-, Cs-u cycloalkyl-Ci-e alkyl-, (5-14 membered heteroaryl)-Ci-6 alkyl-, and (4-14 membered heterocycloalkyl)-C ue alkyl-;each RJdand Rk5is independently selected from OH, Ci-e alkoxy, and Cj-ehaloalkoxy; or, any R'5and Rtoattached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-mem bered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from Cue alkyl and Ci-6haloalkyl; each R!is independently selected from 13, halo, oxo, Cj-6alkyl, Cj-6ha!oaikyl, C2-s alkenyl, C2-6alkynyl, Ce-u aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C w ar I-C1-& alkyl-, C3-14 cycloalkyl-Ci-e alkyl-, (5-14 membered heteroaryl)-C]-6 alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6 alkyl-, CN, NO2, ORab, SRa6, NHORa5, C(0)Rm, C(0)NRC6R··6, C(0)NRc6(0Ra6). C(0)0Ra6, GC(0)Rb6,()('(()).\ R:'RI:'. NRc6Rd6, NRc6NRcbRdb, NRc6C(0)Rb6, NRc6C(0)0Ra6, NRc6C(0)NRc5Rd6, C(=NRe6)Rb6, C(=NRe6)NRc6Rd6, NRc6C(=NRe6)NRc6Rd6, NRc6C(=NRe6)Rb6, NRc6S(0)Rb6, NRc6S(0)NRc6Rd6, N R 'S 3) R!NRc6S(0)(=NRe6)Rb6, NRc6S(0)2NRc6Rd6, S(0)Rb6, S(0)NRc6Rd6, S(0)2Rb6, S(0)2NRc6Rd6, 0S(0)(=NRe6)Rb6, 0S(0)2Rb6, SFs, P(0)Rf6Rg6, 0P(0)(0Rh6)(0Ri6), P(0)(0R“)(0Ris), and BR6Rk6, wherein the CMalkyl, C2.&alkenyl, CMalkynyl, Ca-u aryl, C3-i4cycloalkyl, 5-14 membered heteroaryd, 4-14 memberedheterocycloalkyl, Ce- aryl-C 1 -5 alkyl-, C3-14 cycloalky l-Ci-6 alkyl-, (5-14 membered heteroarvd)-Ci-6alkyl-, and (4-14 membered heterocycloalkyl)-C [-6alkyl- of R1are each optionally substituted with 1 , 2, 3, or 4 independently selected RJsubstituents;each Ra6, Rc6, and Rd5is independently selected from H, Ci-&alkyl, Ci-&haloalkyl, C2..e alkenyl, C2-e alkynyl, C&-14 aryl,€3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-i4 ar l-Ci-6 alkyl-, C3-14 cycloalkyl-Ci-e alkyl-, (5-14 membered heteroaryl)-C]^ alkyl-, and (4-14 membered heterocycloalky 1)-Cw alkyl-, wherein the Cj-6alkyl, C2-&alkenyl, C2-6alkynyl, Ce-u aryl, C3-14 cycloalky l, 5-14 membered heteroaryd, 4-14 membered heterocycloalkyl, CS-Mary l-Ci-6alkyl-, C3-14 cycloalkyl-Ci-e alkyl-, (5-14 membered heteroaryl)-C]-6alkyl-, and (4-14 membered heterocycioalkyl)-Ci-6alkyl- of Ra6, Rc6, and Rd6are each optionally substituted with 1, 2, 3, or 4 independently selected RJsubstituents; or any Rc6and R* attached to the same N atom, together with the N atom to which they are attached, form a 5- or 6-membered heteroaryl or a 4-14 membered heterocycloalkyl group, wherein the 5- or 6-membered heteroaryl or 4-14 membered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected RJsubstituents;each Rb6is independently selected from H, Cj-6alkyl, Cj-6haloalk l, C2.&alken l, C2-&alkynyl, Ca-u aryl, C3-i4cycloalkyl, 5-14 membered heteroaryd, 4-14 memberedheterocycloalkyl, Ce-i aryd-Ci-e alkyl-, Cs-u cycloalkyl-Ci-e alkyl-, (5-14 membered heteroaryl)-Ci-6 alkyl-, and (4-14 membered heterocycloalkyl)-C i-6 alkyl-, wherein the Ci-galkyl, C2-6alkenyl, C2-6alkynyl, Ce-u arvd, C3-i4 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, CM* aryl-Ci-e alkyl-, C3-Mcycloalky 1-Ci-e alkyl-, (5-14 membered heteroaryl)-C 1-6 alkyl-, and (4-14 membered heteroeycloalkyl)-C i-s alkyl- of RDbare each optionally substituted with 1, 2, 3, or 4 independently selected RJsubstituents;each Rabis independently selected from H, OH, CN, Cj-6alkyl, Ci-e alkoxy, C M haloalkyl, Cj-ehaloalkoxy, C2-6 alkenyl, C2-6alkynyl, Ce-u aryl, 63-14 cycloalkyl, 5-14 membered heteroaiyl, 4-14 membered heterocycloalkyl, C&-14 ary l-Ci-6 alkyl-, C3-14 cycloalkyl- C 1-6 alkyl-, (5-14 membered heteroaiy l)-Ci-6alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6alkyl-;each Rfband Rg5is independently selected from H, Ci-6alkyl, Cj-e alkoxy, C i-6haloalkyl, Ci-ehaioalkoxy, C2-s alkenyl, C2-6alkynyl, Ce-w aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl,aryl-C w, alkyl-, C3-14 cycloalkyl- Ci-6alkyl-, (5-14 membered heteroaiyll-Ci-g alkyl-, and (4-14 membered heterocycloalkyll-C]- s alkyl-;each Rhband Rlbis independently selected from H, C ue alkyl, C i-b haloalkyl, C2-6 alkenyl, C2-6alkynyl,€5-14 aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C w ary l-Cw alkyl-, C3-14 cycloalkyl-Ci-e alkyl-, (5-14 membered heteroaiy l)-C]-6 alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6 alkyl-;each RJband R*° is independently selected from OH, Ci^alkoxy, and Ci-ehaloalkoxy ; or, any RJband Rkbattached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from C i-e alkyl and Chr, haloalkyl;each RJis independently selected from D, halo, oxo, Che alkyl, Ci-6haloalkyl, C2-6alkenyl, C2-6 alkynyl, C&-14 aryl, C3..14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-u aryl-C i-e alkyl-, C3-i4cycloalkyl-Ci-6 alkyl-, (5-14 membered heteroaryl)-Ci-6alkyl-, and (4-14 membered heterocycloalky l)-Ci-6alkyl-, CN, NO2, ORa?,SR!!. NHORa7, C(0)Rfc7, C(0)NRc7Rd7, C(0)NRc7(0Ra7), C(0)0Ra7, 0C(0)Rb7,0C(0)NRc7Rd7, NRc7Rd7, NRc7NRc7Rd7,NRc7C(0)Rb7, NRc7C(0)0Ra7, NRc7C(0)NRc7Rd7, C(=NRe7)Rb?, C(=NRe7)NRc7Rd7, NRc7C(=NRe7)NRc7Rd7, NRc7C(=NRe7)Rb7, NRc7S(0)Rb7,NRc7S(0)NRc7Rd7, NRc7S(0)2Rb7, NRc7S(0)(=NRe7)Rb7, NRc7S(0)2NRc7Rd7, S(0)Rb7, S(0)NRc7Rd7, ScOi -R1'. S(0)2NRc7Rd7. 0S(0)(=NRe7)Rb7, 0S(0)2Rb7, SF5, P(0)Rf;Rg7, OP(0)(ORh,)(OR! / ), P(0)(0R“7)(0Rl7), and BRj7Rk / , wherein the C M alkyl, C2-6 alkenyl, C2-6 alkynyl, Ce-u aryl, C3-Hcycloalkyl, 5-14 membered heteroaiyl, 4-14 memberedheterocycloalkyl, C w ary l-Cw alkyl-, C3-14 cycloalkyl-Ci-e alkyl-, (5-14 memberedheteroaryl)-C]-6alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6alkyl- of RJare each optionally substituted with 1 , 2, 3, or 4 independently selected R substituents;each Ra / , Rc', and Rd7is independently selected from H, C i-s alkyl, Ci-s haloalkyl, C2-6alkenyl, C2-s alkynyl, C&-14 aryl, C3..14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-u aryd-C i-e alkyl-, C3-i4 cycloalkyl-Ci-6 alkyl-, (5-14 membered heteroaryl)-Ci-6alkyl-, and (4-14 membered heterocycloalkyl)-C 1-6 alkyl- wherein the Ci-e alkyl, C2-6alkenyl, C2-f,alkynyl, Ce-w aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-u aryl-Cj-e alkyl-, CS-Mcycloalky l-Ci-6 alkyl-, (5-14 membered heteroaryi)-Ci-6alkyl-, and (4-14 membered heterocycloalky i)-Ci-6alkyl- of Ra / , Rc', and Rd' are each optionally substituted with 1, 2, 3, or 4 independently selected RKsubstituents; or any R0?and Rd / attached to the same N atom, together with the N atom to which they are attached, form a 5- or 6-membered heteroary l or a 4-14 membered heterocycloalkyl group, wherein the 5- or 6-membered heteroaryl or 4-14 membered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected RKsubstituents;each Rb / is independently selected from H, Ci-6alkyl, Cj-6haloalkyl, C2-s alkenyl, C2-6 alkynyl, C&.14 aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 memberedheterocycloalkyl, Ce-w ary I-C1-&alkyl-, C3-14 cycloalkyl-Ci-e alkyl-, (5-14 membered heteroaryl)-C]-6alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6 alkyl-, wherein the Cj-e alkyl, C2-6 alkenyl, C2-6 alkynyl, C&.14 aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Cs-w aryl-Ci-e alkyl-, CVw cycloalkyl-Ci-e alkyl-, (5-14 membered heteroaryl)-Ci.6 alkyl-, and (4-14 membered heterocycloalkyl)-C½alkyl- of Rb?are each optionally substituted with 1 , 2, 3, or 4 independently selected R substituents;each Re' is independently selected from H, OH, CN, Ci-e alkyl, C2-6 alkenyl, C5-6 alkoxy, Ci-b haloalkyl, Cwhaloalkoxy, C2-6 alkynyl, Ce-w aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, and 4-14 membered heterocycloalkyl;each Rf / and Rg?is independently selected from H, C .-s alkyl, Ci« alkoxy, Ci-e haloalkyl, Ci-ehaloalkoxy, C2-6 alkenyl, C2-e alkynyl, C&-J4 aryl,cycloalkyl, 5-14 membered heteroary l, 4-14 membered heterocycloalkyl, Ce-u ary l-Ci-6alkyl-, C3-14 cycloalky 1- C [-6alkyl-, (5-14 membered he teroarydi-Ci-f, alkyl-, and (4-14 membered heteroeycioalkyli-Ci-6alkyl-;each Rh / and R1' is independently selected from H, Ci-6 alkyl, Ci-6 haloalkyl, C2.6 alkenyl, C alkynyl, Ce-w aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-i aiyl-Ci-6 alkyl-, Cs-u cycloalkyi-Ci-e alkyl-, (5-14 membered heteroaryd)-Ci-6alkyl-, and (4-14 membered heterocycloalkyl)-C i-6alkyl-;each RJ' and RK / is independently selected from OH, Ci-ealkoxy, and C -ehaloalkoxy; or, any RJ / and Rk' attached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-mem bered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from Ci-e alkyl and Ci-6haloalkyl;each RKis independently selected from H, D, OH, halo, oxo, CN, C(0)QH, NH2,NO?, SFS, CWalkyl, Ci-ealkoxy, Ci-ehaloalkoxy, Ci-e haloalkyl, C2-e alkenyl, C2-&alkynyl, C<s- i4aryl, C3-34cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-u aryl-Ci-6alkyl-, CX-Kcycloalkyl-Ci-g alkyl-, (5-14 membered heteroaiyl)-Ci-6 alkyl-, and (4-14 membered heterocycloalky 1)-Ci..6 alkyl-; andwherein any heteroaryl group of any of the above-recited substituents optionally comprises an N -oxide on any ring-forming nitrogen.In some embodiments:X is N;RJis selected from H, C1-6 alkyl, C1.6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, Ce-u and, C3-14 cycloalky I, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-uaryl-Cw alkyl-, C3-14 cycloalkyl-Ci-e alkyl-, (5-14 membered heteroaryl)-Ci..6 alkyl-, (4-14 membered heterocy c!oalky!)-C w, alkyl-, ORal, C(0)Rbl, C(0)NRciRdi, C(0)0Ral, C(=NRel)Rbl, C(=NRel)NRclRdl, S(0)Rbl, S(O)NR0lRdl, S(0)2Rbl, and S(0)2NRo!Rd!, wherein the Ci-6alkyl, C2-&alkenyl, C2-&alkynyl, Ce-i4 aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, CX-Maryl-Ci-6alkyl-, CVw cycloalkyl-Ci-e alkyl-, (5-14 membered heteroaiyl)-Ci-6alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6alkyl- of R]are each optionally substituted with 1 , 2, 3, 4, 5, 6, 7, or 8 independently selected RBsubstituents;R2is selected from H, D, halo, C -6 alkyl, C -6 haloalky l, C2-6alkenyl, C2-e alkynyl, Ce- 14 aryl, C3-14 cycloalky l, 5-14 membered heteroaryl, 4-14 membered heierocycloalkyl,€5-1 aryd-C -6 alkyl-, Cn-i Cycloalkyl-Ci-e alkyl-, (5-14 membered heteroaryl)-Ci-6 alkyl-, (4-14 membered heterocycloalkyl)-Cw alkyl-, CN, N02, ORa3, SRa2, NHGRai, C(0)Rb2,('iO)NR R;. C (0)NRc2(0Ra2), C(0)0R32, 0C(0)Rb2, 0C(0)NRc2Rd2, N R- Rd.NRc2NRc2Rd2, NRc2C(0)Rb2, NRc2C(0)0Ra2, NRc2C(0)NRc2Rd2, C(=NRe2)Rb2,C (=NRe2)NRc2Rd2, NRc2C (=NRc2)NRc2Rd2, NRc2C(=NRe2)Rb2, NRc2S(0)NRc2Rd2,NRc2S(0)Rb2, NRC2S(0)2Rm, NRc2S(0)(=NRe2)Rb2, NRc2S(0)2NRc2Rd2, S(0)Rb2,S(0)NRc2Rd2, S(0)2Rb2, S(0)2NRc2Rd2, 0S(0)(=NRe2)Rb2, 0S(0)2Rb2, SF5, P(0)Rf2Rg2, 0P(0)(0Rh2)(0Ri2), P(0)(0R!l2)(0Rl2), and BRj2Rk2, wherein the CMalkyl, C2-6 alkenyl, C2-6 alkynyl, Ce-u aryl, C3-14cycloalkyl, 5-14 membered heteroaiyl, 4-14 memberedheterocycloalkyl, C w aryl-Ci-6 alkyl-, C3-14 cycloalkyl-Ci-e alkyl-, (5-14 memberedheteroaryl)-C -6 alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6alkyl- of R3are each optionally substituted with 1 , 2, 3, 4, 5, 6, 7, or 8 independently selected Rcsubstituents;Cy!is C&-14 aryl,€3-14 cycloalkyl, 5-14 membered heteroaryl, or 4-14 membered heterocycloalkyl, wherein the Ce-u aryl, C3 -14 cycloalky 1, 5-14 membered heteroaryl, or 4-14 membered heterocycloalkyl is optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R&substituents;provided that when Cy!is 4-14 membered heterocycloalkyl, then the 4-14 membered heterocycloalkyl of Cy1is other than unsubstituted morpholinyl;Cyzis Ce-14 aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, or 4-14 membered heterocycloalkyl, wherein thearyl, C3-14 cycloalky 1, 5-14 membered heteroaryl, or 4-14 membered heterocycloalkyl is optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R" substituents;each Ral, Rci, Rdl, Ra2, R°2, and Rd2is independently selected from H, C -e alkyl, Cue haloalkyl, C2-6 alkenyl, C2-6 alkynyl, Ce-w aryl, C3.14 cycloalkyl, 5-14 membered heteroaryl, 4- 14 membered heterocycloalkyl, CKaryl -Ci-s alkyl-, C;-i4eyeloalkyi-C 1-6 alkyl-, (5-14 membered heteroaryl)-Ci-6 alkyl-, and (4-14 membered heterocycloalkyl)-Ci..6 alkyl-, wherein the C -6 alkyl, C2-6 alkenyl, C2-6 alkynyl, Ce-w aiyl, C3-Mcycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C&.J4 ary l-Ci-s alkyl-, Cs-ircycloalkyl-C -e alkyl-, (5-14 membered heteroaryi)-Ci-6alkyl-, and (4-14 membered heterocycloalky l)-Ci-6alkyl- of Ral, Rcl, Rdl, Ra2, Rc2, and Rd2are each optionally substituted with 1 , 2, 3, 4, 5, 6, 7, or 8 independently selected R<Jsubstituents;or, any Rcland Rdlattached to the same N atom, together with the N atom to which they are attached, form a 5- or 6-membered heteroaryl or a 4-14 membered heterocycloalkyl group, wherein the 5- or 6-membered heteroaryl or 4-14 membered heterocycloalkyl group is optionally substituted with 1 , 2, 3, or 4 independently selected ' substituents;or any Rc2and Rd2attached to the same N atom, together with the N atom to which they are attached, form a 5- or 6-membered heteroaryl or a 4-14 membered heterocycloalkyl group, wherein the 5- or 6-membered heteroary l or 4-14 membered heterocycloalkyl group is optionally substituted with 1 , 2, 3, or 4 independently selected R° substituents;each Rbland Rb2is independently selected from H, Ci-s alkyl, Ci-e haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C&-14 aryl, C3..14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-u aryl-C i-b alkyl-, C3-i4 cycloalkyl-Ci-6 alkyl-, (5-14 membered heteroaryl)-Ci-6alkyl-, and (4-14 membered heterocycloalky 1)~CR>alkyl-, wherein the CMalkyl, C2-6 alkenyl, C2-6 alkynyl, C&-J4 aryl, CJ-Mcycloalkyl, 5-14 membered heteroaryl, 4-14membered heterocycloalkyl, Ce-u aryl-C -e alkyl-, Ci-u cycloalkyl-C -6 alky' 1-, (5-14 membered heteroaryl)-C]-6 alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6 alkyl- of RBi, Rb2, and Rb’ are each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R° substituents;each RBland Re2is independently selected from H, OH, CN, C i-s aikyl, C i-s alkoxy, Ci-6haloalkyl, C -e haloalkoxy, C2-6 alkenyl, C2-6 alkynyl, Ce-u aryi, Cs-u cycloalkyi, 5-14 membered heteroaryl, 4-14 membered heierocycloalkyl, CM* ary l-Ci-6 alkyl-, C3-14 cycloalkyl- C 1.6 alkyl-, (5-14 membered heteroaryi)~Ci-6 alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6alkyl-;eachGand Rg2is independently selected from H, Ci-6alkyl, C -e alkoxy, CM>haloalkyl, Ci-ehaloalkoxy, C2-6 alkenyl, C2-6 alkynyl, Ce- aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-u aryl-C i-e alkyl-, C3-14 cycloallcyl- Ci-6alkyl-, (5-14 membered heteroaiyll-Ci-g alkyl-, and (4-14 membered heterocycloalkyl)-C]- s alkyl-;each RMand Rl2is independently selected from H, C i-s alkyl C i-b haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C&.14 aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, CMary I-C1-& alkyl-, C3-14 cycloalkyl-Ci-e alkyl-, (5-14 membered heteroaryl)-C]-6 alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6 alkyl-;each Rj2and R*“ is independently selected from OH, Ci-ealkoxy, and Ci-ehaloalkoxy ; or any Rj2and RKattached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from C i-6alkyl and C -6haloalkyl;each Rb, Rc, R , Rb, and RGis independently selected from D, halo, oxo, Ci-6alkyl, Ci-6 haloalkyl, C2-6 alkenyl, C2-e alkynyl,aryl, C3.14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-14 aryl-C i-s alky!-, Ci-w cyeloalkyl-C 1.5 alkyl-, (5-14 membered heteroaryl)-Ci-6 alkyl-, (4-14 membered heterocycloalkyl)-Ci-6 alkyl-, CN, NO?., ORa4, SRa4, N S i()R! lC(0)Rb4, C(0)NRc4Rd4, C(0)NRc4(0Ra4), C(0)0Ra4, 0C(0)RM, 0C(0)NRc+Rd+, NRc4Rd4, NRc4NRc4Rd4NRe4C(0)RM, NRc4C(0)0R34, NRc4C(0)NRc4Rd4, C(=NRe4)Rb4, C (=NRe4)N Rc4Rd4, NRc4C(=NRe4)NRc4Rd4, NRc4C(=NRe4)RM, NRc4S(0)Rb4, NRc4S(0)NRc4Rd4, NRc4S(0)2Rb4, NRc4S(0)(=NRe4)RM, NRc4S(0)2NRc4Rd4, S(0)Rb4, S(0)NRe4Rd4, S(0)2Rb4, S(0)2NRc4Rd4, 0S(0)(-NRe4)Rb4, 0S(0)2RM, SF5, P(0)Rf4Rg4, 0P(0)(0Rh4)(0Rl4), P(0)(0R“4)(0Rl4), and BRj+Rk4, wherein the Cw alkyl, C2-6 alkenyl, C2-6 alkynyl, Ce-u aryi, C3-Mcycloalkyi, 5-14 membered heteroaiyi, 4-14 memberedheterocycloalkyl, CVM aryl-Ci^, alkyl-, C3-14 cycloalkyl-Ci-e alkyl-, (5-14 memberedheteroaryl)-C -6 alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6alkyl- of Rb, Rc, Rb, R1', and R'Jare each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected Rhsubstituents;each Ra4, Rc4, and Rd4is independently selected from H, Ci-6alkyl, Ci-6haloalkyl, C2-6 alkenyl, C2-6 alkynyl, Ce-u aryl, Cj-w cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-ir aiyl-Ci-6 alkyl-, Cs-u cycloalkyi-Ci-e alkyl-, (5-14 membered heteroaryl)-Ci-6 alkyl-, and (4-14 membered heterocycloalkyl)-C i-e alkyl-, wherein the Ci-6alkyl, C2-6 alkenyl, C2-6 alkynyl, Ce-i+aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Cs-w aryl-C -6alkyl-, C3-14 cycloalk l-Ci-6alkyl-, (5-14 membered heteroaryd)-C 1-6 alkyl-, and (4-14 membered beteroeycloaikyi)-Ci-6alkyl- of Ra4, Rc4, and Rd4are each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected Rflsubstituents;or, any Rc4and Ra4attached to the same N atom, together with the N atom to -which they are attached, optionally form a 5- or 6-membered heteroaryl or a 4-14 membered heterocycloalkyl group, -wherein tire 5- or 6-membered heteroaryl or 4-14 membered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected RHsubstituents;each Rwis independently selected from H, Ci-6alkyl, Ci-6haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C&.14 aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 memberedheterocycloalkyl, Ce-i4 ar t-C -6 alkyl-, Cs-w cycloalkyl-Ci-e alkyl-, (5-14 membered heteroaryl)-Ci-6alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6alkyl-, wherein the Ci-6alkyl, C2-6 alkenyl, C2-6 alkynyl, Ce-w aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-u aryl-C -6 alkyl-, Cs-u cycloalky l-Ci-e alkyl-, (5-14 membered heteroaryl)-Ci.6alkyl-, and (4-14 membered heterocycioalkyl)-Ci-6alkyl- of Rs4are each optionally substituted with 1 , 2, 3, 4, 5, 6, 7, or 8 independently selected RHsubstituents; each Re4is independently selected from H, OH, CN, Ci-e alkyl, Ci-e alkoxy , Ci-6haloalkyl, C -ehaloalkoxy, C2-6 alkenyl, C2-6 alkynyl, C&-J4 aryl, Cs-u cycloalky 1, 5-14 membered heteroary l, 4-14 membered heterocycloalkyl, Ce-u ary l-Ci-6alkyl-, C3-14 cycloalky 1- C [-6 alkyl-, (5-14 membered he teroarydi-Ci-f, alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6alkyl-;each Rf4and R84is independently selected from H, Ci-6alkyl, Ci-6alkoxy, Ci^ haloalkyl, Ci-ehaloalkoxy, C2-6 alkenyl, C2-6 alkynyl, Ce-w aryl, Ch-w cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-ir aiyd-Ci-6alkyl-, Cs-u cycloalkyi-C 1-6 alkyl-, (5-14 membered heteroaryl) ~Ci-6 alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6alkyl-;each Rh+and Rl4is independently selected from H, Ci-6alkyl, Ci-6haloalkyl, C2-6alkenyl, C2-s alkynyl, C aryl, C3..14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, CM* aryl-C i-e alkyl-, C3-i4 cycloalkyl-Ci-6 alkyl-, (5-14 membered heteroaryl)-Ci-6alkyl-, and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;each Rj4and Rk4is independently selected from OH, Cj-ealkoxy, and Ci-ehaloalkoxy; or, any Rjand Rk+attached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-membered heterocycloalky 1 group optionally substituted -with 1, 2, 3, or 4 substituents independently selected from Cj-6alkyl and Cs-6haloalkyl;each RHis independently selected from D, halo, oxo, Cue alkyl, CR>haloalkyl, C2-6 alkenyl, C2-f,alkynyl, Ce-w aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C6-i4 aiyl-Ci-6 alkyl-, Cs-u cycloalkyl-Ci-e alkyl-, (5-14 membered heteroaiyl)-Ci-6 alkyl-, (4-14 membered heterocycloalkyl)-Ci-6 alkyl-, CN, N02, OR85, SR3", NHORa5, C(0)Rb5, C(0)NRc5Rd5, C(0)NRc5(0Ra5), C(0)0Ra5, 0C(0)Rbs, 0C(0)NRc5Rd5, NRc5Rd5, NRc5NRc5Rd5,NRe5C(0)Rb5, NRc5C(0)0R3?', NRc5C(G)NRc5Rd5, C(===NRe5)Rh5, C(=NRe5)NRc5Rd5, NRc5C(=NRe5)NRc5Rd5, NRcSC(=NReS)Rbs, NRc5S(0)RM,NRc5S(0)NRc5Rd5, NRc5S(0)2Rh5, NRc5S(0)(=NRe5)Rb5, NRc5S(0)2NRc5Rd5, S(0)Rb5,SiOjN R- R4 '. S(Oj Rh '. S(0)2NRc5Rd5, 0S(0)(=NRe5)Rb5, GS(0)2Rb5, SF5, P(0)R¾85, OP OXOR^XQR15), P(0)(0R!r!)(0Ri:), and BRj5Rk5, wherein the Ci-6alkyl, C2-&alkenyl, C2-6 alkynyl, C&-14 aryl,€3-14 cycloalky 1, 5-14 membered heteroaryl, 4-14 memberedheterocycloalkyl, CM* aiyl-C [-6 alkyl-, C3-14 cycloalkyl-Cj-e alkyl-, (5-14 membered heteroaryl)-Ci-6alkyl-, and (4-14 membered heterocycloalky 1)-CR>alkyl- of RHare each optionally substituted with 1, 2, 3, or 4 independently selected R!substituents;each R35, Rc5, and Rd" is independently selected from H, Ci-e alkyl, Ci-6haloalkyl, C2-6 alkenyl, C2-6 alkynyl,€5-14 aryl, C3-1 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, CM* ar I-C -&alkyl-, C3-14 cycloalkyl-Ci-e alkyl-, (5-14 memberedheteroaryl)-C]-6alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6alkyl-, wherein the C -e alkyl, C2-&alkenyl, C2-&alkynyl, CM* aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, CX-w aryi-Cj-6alkyl-, CVw cyctoalkyl-Ci-e alkyl-, (5-14 membered heteroaryl)-Ci.6alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6alkyl- of R3>, Rc5, and Rd5are each optionally substituted with 1 , 2, 3, or 4 independently selected R1substituents;or any Rcand Rd5attached to the same N atom, together with the N atom to which they are attached, form a 5- or 6-membered heteroaryl or a 4-14 membered heterocycloalkylgroup, wherein the 5- or 6-membered heteroary l or 4-14 membered heterocycloalkyl group is optionally substituted with 1 , 2, 3, or 4 independently selected R1substituents;each Rb5is independently selected from H, Cue alkyl. Cue haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C&-1 aryl, C3-14 cycloalky 1, 5-14 membered heteroaryl, 4-14 memberedheterocycloalkyl, Ce-u aryl-CMalkyl-, ifr-n eyeloalkyl-C alkyl-, (5-14 membered heteroaryl)-Ci-6alkyl-, and (4-14 membered heterocycloalky 1)-C R>alkyl-, wherein the CM alkyl, C?_-f>alkenyl, C2-6 alkynyl, Ci.-u aryl, CJ-Mcycloalky 1, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Cs-ir aryl-Ci-e alkyl-, Ch-u cycloalkyl-Cj-e alkyl-, (5-14 membered heteroaryl)-Ci-6alkyl-, and (4-14 membered heterocycloalky 1)-C 1.6 alkyl- of R”3are each optionally substituted with 1, 2, 3, or 4 independently selected R1substituents;each Rs?'is independently selected from H, OH, CN, CMalky l, Ci-e alkoxy, C haloalkyl, C;i-f!haloalkoxy, C2-6 alkenyl, C2-6 alkynyl, Ce-w aiyl, C3-Mcycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C6-i4 aiyl-Ci-6alkyl-, C3-14cycloalky!- Ci-6alkyl-, (5-14 membered heteroaryl) -C1-6 alkyl-, and (4-14 membered heterocycloalkyl)-Ci-&alkyl-;each Rband Rg5is independently selected from H, CMalkyl, Ci« alkoxy, Ci-6haloalkyl, Cj-ehaloalkoxy, C2-6 alkenyl, C2-6 alkynyl, (M-Maryl, C3-14cycloalky 1, 5-14 membered heteroaryi, 4-14 membered heterocycloalkyl, Ce-u ary' i-C 1-6 alkyl-, C3-i4 cyc!oalky 1- CM alk l-, (5-14 membered heteroaiyl)-Ci-6alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6alkyl-;each Rtoand R15is independently selected from H, CM alkyl, C haloalkyl, C2-6 alkenyl,€2-6 alkynyl, Ce-w aryl, C3-14 cycloalkyl, 5-14 membered heteroaryi, 4-14 membered heterocycloalkyl, Ce-w aiyl-Ci-6 alkyl-, Cs-u cycloalkyi-Ci-e alkyl-, (5-14 membered heteroaryl)-Ci.6 alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6 alkyl-;each Rpand R*5is independently selected from OH, Cj-s aikoxy, and Ci-shaloalkoxy; or, any Rj5and R*5attached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from C alkyl and C 1-6 haloalkyl;each R1is independently selected from D, halo, oxo, C , alkyl, C , haloalkyl, C2-6 alkenyl, C2-6 alkynyl, Ce-u aryl, C3-14 cycloalkyl, 5-14 membered heteroaryi, 4-14 membered heterocycloalkyl, Ce-w ary 1-CMalkyl-, C3-14 eyeloalkyl-Ci-e alkyl-, (5-14 membered heteroaryl)-Ci-6aikyl-, and (4-14 membered heterocycioalkyi)-Ci-6alkyl-, CN, N(¾, ORa6,C(=NRe6)Rb6, C(=NRe6)NRc6Rd6, NRc6C(=NRe6)NRc6Rd6, NRc6C(=NRe6)Rb6, NRc6S(0)Rb6, NRc5S(0)NRc5Rd5, N RC SiOi -R1". NRc5S(0)(=NRc5)Rb6, NRc6S(0)2NRc5Rd6, S(0)Rb6, S(0)NRc6Rd6, S(0)2Rb6, S(0)2NRc5Rd6, 0S(0)(=NRe6)Rb6, 0S(0)2Rb6, SF , P(0)Rf6Rg6, 0P(0)(0Rh6)(0Ri6), P(0)(0Rh6)(0R6), and BR-,6Rk6, wherein the CMalkyl, C2.&alkenyl, CMalkynyl, Ca-u aryl, Ch-w eyeloalkyi, 5-14 membered heteroaryl, 4-14 memberedheterocycloalkyl, Ce-ir aiyl-Ci-6 alkyl-, Cs-u cycloalkyl-Ci-e alkyl-, (5-14 membered heteroaryl)-Ci-6 alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6 alkyl- of R!are each optionally substituted with 1 , 2, 3, or 4 independently selected RJsubstituents;each R36, Rc6, and Rd5is independently selected from H, Ci-&alkyl, Ci-&haloalkyl, C2..e alkenyl, C2-e alkymyl, C&-Karyl, C-t-u cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-w ary l-Ci-6 alkyl-, Ca-i+cycloalkyl-C -e alkyl-, (5-14 membered heteroaryl)-C]^ alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6alkyl-, wherein the C -6alkyl, C2-&alkenyl, C2-6alkynyl, Ce-u aryl, Cs-u cycloalkyi, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, CS-Maryl-Cw alkyl-, C3-14 cycloalkyl-Ci-e alkyl-, (5-14 membered heteroaryl)-Ci-6 alkyl-, and (4-14 membered heterocycloalky l)-C]-6 alkyl- of Ra6, Rc6, and Rd6are each optionally substituted with 1, 2, 3, or 4 independently selected RJsubstituents;or any Rc6and R* attached to the same N atom, together with the N atom to which they are attached, form a 5- or 6-membered heteroaryl or a 4-14 membered heterocycloalkyl group, wherein the 5- or 6-membered heteroaryl or 4-14 membered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected RJsubstituents;each Rbois independently selected from H, CM alkyl, CM haloalk l, C2.6alkenyl, C2-&alkynyl, Ce-w aryl, C3-Hcycloalkyl, 5-14 membered heteroaryl, 4-14 memberedheterocycloalkyl, Ce-ir aiyl-Ci-6 alkyl-, Cs-u cycloalkyi-Ci-e alkyl-, (5-14 membered heteroaryl)-Ci.6 alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6 alkyl-, wherein the CMalkyl, C2-&alkenyl, C2-&alkynyl, CV aryl, Ci-Kcycloalkyl, 5-14 membered heteroaryd, 4-14 membered heterocycloalkyl, Cs-w aryl-Ci-6alkyl-, C3-14 cycloalky l-Ci-6alkyl-, (5-14 membered heteroaryl)-Ci-6 alkyl-, and (4-14 membered heterocycloalkyl)-C ue alkyl- of Rb6are each optionally substituted with 1 , 2, 3, or 4 independently selected RJsubstituents;each Re6is independently selected from H, OH, CN, C , alkyl, Ci-6alkoxy, Ci-6 haloalkyl, C]-6haloalkoxy, C2-s alkenyl, C2-e alkynyl, CKaryl,€3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-i ary l-Ci-6 alkyl-, C3..14 cycloalky 1- C i-6 alkyl-, (5-14 membered heteroaryi)-Ci-s alkyl-, and (4-14 membered heterocycloalkyl)-Ci- 6 alkyl-;each R®and Rs° is independently selected from H, Ci-e alkyl Ci-e alkoxy, Ci-e haloalkyl, C;i-f!haloa3koxy, C2-6 alkenyl, C2-6 alkynyl, Ce-w aiyl, C3-Hcycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Gs-w aryl-C -6alkyl-, Cs-Mcycloalkyl- Ci-6alkyl-, (5-14 membered heteroaryl) -C1-6 alkyl-, and (4-14 membered heterocycloalky 1)-Ci.&alkyl-;each Rh6and R'6is independently selected from H, C -6 alkyl, C -e haloalkyl, C2-6 alkenyl, C2-6 alkynyl, Ci.-u aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, CN-Maryl-Ci-e alkyl-, C -i+ cycloalkyl-C -e alkyl-, (5-14 membered heteroaryl)-Ci-6alkyl-, and (4-14 membered heterocycloalky l)-Ci-6alkyl-;each R'6and Rk6is independently selected from OH, C -s alkoxy, and C i-ehaloalkoxy; or, any Rjf>and Rkbattached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from Ci-e alky l and Ci-e haloalkyl;each R1is independently selected from D, halo, oxo, Ci-b alkyl, Ci-b haloalkyl, C2.6 alkenyl, C2-6 alkynyl, CMaryl, C3-i4 cycloalkyl, 5-14 membered heteroaryd, 4-14 membered heterocycloalkyl, Ce- aryi-C 1.5 alkyl-, C3-1 cycloalky I-C1-6 alkyl-, (5-14 membered heteroaryl)-Ci-6 alkyl-, and (4-14 membered heterocycloalkyl)-C [-6 alkyl-, CN, NO2, ORa7,0P(0)(0Rh7)(0Rl7), P(0)(0Rb7)(0Rl7), and BR· R‘ . wherein the Ci-e alkyl, C2-6alkenyl, C2-6alkynyl, Ce-u aryl,€3-14 cycloalky 1, 5-14 membered heteroaryl, 4-14 memberedheterocycloalkyl, Ce-u aryl-C i-e alkyl-, C3-i4cycloalkyl-C -6alkyl-, (5-14 membered heteroaryl)-Ci-6alkyl-, and (4-14 membered heterocycloalky l)-Ci-6alkyl- of R!are each optionally substituted with 1, 2, 3, or 4 independently selected RKsubstituents;each Ra / , Rc, and Rd' is independently selected from H, Cj-b alkyl, Ci-e haloalkyl, C2-6 alkenyl,€2-6 alkynyl, Ce-w aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-i4 aryl-C -6 alkyl-, Cs-w cycloalkyi-Ci-e alkyl-, (5-14 membered heteroaryl)-Ci.6 alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6 alkyl- wherein the Ci-6 alkyl, C2-6 alkenyl, C2-6 alkymyl, C6-i4 aryl, Ci-Hcycloalkyl, 5-14 membered heteroaryd, 4-14 membered heterocycloalkyl, C6-i4aryl-Ci-e alkyl-, CN- cycloalkyl-Ci-e alkyl-, (5-14 memberedheteroaryl)-C]-6 alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6 alkyl- of Ra', Rc / , and Rd?are each optionally substituted with 1, 2, 3, or 4 independently selected RKsubstituents; or any Rc / and Rd7attached to the same N atom, together with the N atom to which they are attached, form a 5- or 6-membered heteroaryl or a 4-14 membered heterocycloalkyl group, wherein the 5- or 6-membered heteroaryl or 4-14 membered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected RKsubstituents;each Rb;is independently selected from H, Ci-e alkyl, Ci-e haloalkyl, C2-6alkenyl, C2-6 alkynyl, Ce- aryd, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 memberedheterocycloalkyl, Cg-w aryl-C 1.5 alkyl-, C3-14 cycloalky 1-Ci- alkyl-, (5-14 membered heteroaryl)-C 1-6 alkyl-, and (4-14 membered heterocycloaikyi)-Ci-6 alkyl-, wherein the Ci-s alkyl, C2-6 alkenyl, C2-6 alkynyl, C -u aryd, C3-i4 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Cg-u aryl-Ci-e alkyl-, C3-34 cycloalk l-Ci^ alkyl-, (5-14 membered heteroaryl)-Ci-6alkyl-, and (4-14 membered heterocycloaikyi)~Ci-g alkyl- of RB?are each optionally substituted with 1, 2, 3, or 4 independently selected RKsubstituents;each R57is independently selected from H, OH, CN, Ci-g alkyl, C2-6 alkenyl, Ci-g alkoxy, Ci-g haloalkyl, Ci-ghaloalkoxy, C2-6 alkynyl, Cg-ir aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, and 4- 14 membered heterocycloalkyl;each Rf?and Rg / is independently selected from H, Ci-e alkyl, C 1-6 alkoxy, Ci-e haloalkyl, Ci-ghaloalkoxy, C2-6 alkenyl, C2.6 alkynyl, Cgur aryd, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-w aryt-Cj-g alkyl-, Cs-ir eyeloalkyi- Ci-6alkyl-, (5-14 membered heteroaryl) -Ci-g alkyl-, and (4-14 membered heterocycloalky 1)-Ci.6alkyl-;each Rh?and R1' is independently selected from H, Ci-6alkyl, Cj-g haloalkyl, C2-6 alkenyl, C2-6 alkynyl, Cg.u aryd, C3..14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Cg-u aryl-Ci-g alkyl-, Ch-n cycloalkyl-Cj-g alkyl-, (5-14 membered heteroaryl)-Ci-6alkyl-, and (4-14 membered heterocycloalky 1)-C 1.6 alkyl-;each RJ' and RKis independently selected from OH, Cj-g alkoxy, and Ci-ghaloalkoxy; or, any R" and Rk / attached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from Cj-g alkyl and Cs-g haloalkyl;each RKis independently selected from H, D, OH, halo, oxo, CN, C(0)OH, NH2,NO2, SFs, Cj-g alkyl, Cj-g alkoxy, Ci-ghaloalkoxy, Ci-e haloalkyl, CN-g alkenyl, (N-g alkynyl, Cg. 14 a ryl,€3-14 cycloalkyl, 5-14 membered heteroaryi, 4-14 membered heterocycloalkyl, Ce-i4aryl-C M alkyl-, C3-Mcycloalkyl-Ci-6 alkyl-, (5-14 membered heteroaryl)-CM alkyl-, and (4-14 membered heterocycloalky3)-C -6alkyl-; andwherein any heteroaryl group of any of the above-recited substituents optionally comprises an N-oxide on any ring-forming nitrogen.In some embodiments;X is N;R1is selected from H, CMalkyl, C2-6 alkenyl, CMalkynyl, and CMhaloalkyl;R2is selected from H, D, halo, CMalkyl, CMhaloalkyl, C2-6 alkenyl, C2-6 alkynyl, Ce- 14 and, C3.14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-u aryl-Ci-6 alkyl-, CVw cyctoalkyl-CMalkyl-, (5-14 membered heteroaryl)~Ci-6 alkyl-, (4-14 membered heterocycloalky 1)-CMalkyl-, CN, N(¾, GR32, SR32, NHORa2, C(0)Rb3,C(0)NRc2Rd2, C(0)NRc2(0R32), C(0)0Ra2, 0C(0)Rb2, 0C(0)NRc2Rd2, NRc2Rd2,NRc2NRc2Rd2, NRc2C(0)Rb2, NRc2C(0)0R32, NRc2C(0)NRc2Rd2, C(=NRe2)Rb2,C(=NRe2)NRc2Rd2, NRc2C(=NRe2)NRc2Rd2, NR^Ci-NR62)!^2, NRc2S(0)NRc2Rd\NRc2S(0)Rb2, NRc2S(0)2Rb2, NRc2S(0)(=NRe2)Rb2, NRc2S(0)2NRc2Rd2, S(0)Rb2,S(0)NRc2Rd2, SiOi. R1'. S(0)2NRe2Rd2, 0S(0)(=NRe2)Rb2, 0S(0)2Rb2, SF5, P(0)Rf2Re·2, Oih OiiOR ' ii OR d. PCOICOR^COR12), and BRj2Rk2, wherein the CMalkyl, CMalkenyl, C2-6alkynyl, Ce- and, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 memberedheterocycloalkyl, Ce- aryl-C alkyl-, C3-1 cycloalky l-Ci-6 alkyl-, (5-14 membered heteroaryl)-C alkyl-, and (4-14 membered heteroeyeloaikyi)-C[-s alkyl- of R2are each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected Rcsubstituents;Cy1is Ce aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, or 4-14 membered heterocycloalkyl, wherein the Cs-u aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, or 4-14 membered heterocycloalkyl is optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R7 or RMsubstituents;Cy2is Ce-14 aryl, C3.14 cycloalkyl, 5-14 membered heteroaryl, or 4-14 membered heterocycloalkyl, wherein the C -u and, C3-14 cyeloalkyl, 5-14 membered heteroaryl, or 4-14 membered heteroc cloalkyl is optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected Rbsubstituents;each R32, Rc2, and Rd2is independently selected from H, C alkyl, C haloalkyl, CMalkenyl, C2-s alkynyl, C&-14 aryl,€3-1+cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-u aryl-CMalkyl-, Ci-Hcycloalkyl-CMalkyl-, (5-14 membered heteroaryi)-Ci-6alky 1-, and (4-14 membered heterocycloalky 1)~C alkyl-, wherein the CMalkyl. CMalkenyl, CMalkyny l, C&-J4 aryl, C3-i4 cycloalkyl, 5-14 membered heteroaryl, 4-14membered heterocycloalkyl, Ce-u aryl-Ci-e alkyl-, Ci-u cycloalkyl-C -6 alky' 1-, (5-14 membered heteroaryl)-C]-6 alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6 alkyl- of Ra2, Rc, and Rdiare each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected RGsubstituents;or any Rc2and Rd2attached to the same N atom, together with the N atom to which they are attached, form a 5- or 6-membered heteroaryl or a 4-14 membered heterocycloalkyl group, wherein the 5- or 6-membered heteroaryl or 4-14 membered heterocycloalkyl group is optionally substituted with 1 , 2, 3, or 4 independently selected Rusubstituents;each Rb2is independently selected from H, C.-s alkyl, C.-s haloalkyl, C2-6 alkenyl, C2.6 alkynyl, CM* aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 memberedheterocycloalkyl, Ce-w aryl-Ci-e alkyl-, C -i+cycloalkyl-C -e alkyl-, (5-14 membered heteroaryl)-C]-6 alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6 alkyl-, wherein the C -6 alkyl, C2-6 alkenyl, C2-6 alkynyl, Ce-u aryl, Cs-u cycloalkyi, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl,aryl-Cw alkyl-, C3-14 cycloalkyl-Ci-e alkyl-, (5-14 membered heteroaryl)-Ci-6 alkyl-, and (4-14 membered heterocycloalky l)-C]-6alkyl- of Rfc2are each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R<Jsubstituents; each Re2is independently selected from H, OH, CN, Ci-e alkyl, C 1-5 alkoxy, Ci-& haloalkyl, Ci-ehaloalkoxy, C2-6 alkenyl, C2-6 alkynyl, Ce- aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalky 1, CM* aryd-C 1-5 alkyl-, C3-14 cycloalky 1- C -6 alkyl-, (5-14 membered heteroaryl)-C]-6 alkyl-, and (4-14 membered heterocycloalkyl)-C].s alkyl-;each RGand Rg2is independently selected from H, Ci-e alkyl, Ci-b haloalkyl, C -6alkoxy, C 1-6 haloalkyl, Ci-ehaloalkoxy, C2-6 alkenyl, C2-6 alkynyl, Cs-u aryl, C3-i4cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Cs-u aryl-Ci-e alkyl-, C3 -14 cycloalkyl-Ci-6 alkyl-, (5-14 membered heteroaryl)-Ci-6 alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6 alkyl-;each Rh2and Rl2is independently selected from H, C -6alkyl, C -6haloalkyl, C2-6 alkenyl, C2-6 alkynyl, Ce-u aryd, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, CM* aryd-C [-6 alkyl-, C3-Hcycloalkyl-C]^ alkyl-, (5-14 membered heteroaryl)-C 1-6 alkyl-, and (4-14 membered heterocyeloalkyd)-Ci-6 alkyl-;each RJand Rk2is independently selected from OH, Ci-&alkoxy, and Ci-ehaloalkoxy; or any R2and Rk2attached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-membered heterocycloalky 1 group optionally substituted with 1, 2, 3, or 4 substituents independently selected from CMalkyl and C 1-5 haloalkyl;each Rc, RE, RM, Rf, and R° is independently selected from D, halo, oxo, Ci-e alkyl, C [-6haloalkyl, C2.galkenyl, C2-6 alkynyl, Cg-u and, C3-14cycloalkyl, 5- 14 membered heteroatyl, 4-14 membered heterocycloalky 1, Ce-u aryl-Ci alkyl-, C3-Hcycloalkyl-Ci-e alkyl-, (5-14 membered heteroaryl)-Ci-g alkyl-, (4-14 membered heterocycloalkyl)-Ci-g alkyl-, CN,0P(0)(0Rn4)(0RI+), P(0)(0RM)(0R14), and BRjRk+, wherein the C -g alkyl, C2-galkenyl, C2-6 alkynyl, Ce- aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 memberedheterocycloalkyl, CM* aiyl-C i-g alkyl-, C3-14cycloalkyl-Cj-e alkyl-, (5- 14 membered heteroaryl)-Ci-6alkyl-, and (4-14 membered heterocycloalkyi)~Ci-g alkyl- of Rc, RE, RM, RF, and RGare each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected RHsubstituents;each Ra4, Rc+, and Rd4is independently selected from H, Ci-g alkyl, Ci-g haloalkyl, C2..galkenyl, C2-galkynyl, Cg-u aryl, C -u cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Cg-i4ary 1-Ci-g alkyl-, C -i+ cycloalkyl-C -g alkyl-, (5-14 membered heteroaryl)-Ci-6alkyl-, and (4-14 membered heterocycloalky l)-Ci-6alkyl-, wherein the Ci-g alkyl, C2-galkenyl, C2-galkynyl, Cg-n aryl, C3-i4 cycloalkyl, 5-14 membered heteroaryd, 4-14 membered heterocycloalkyl, C -n ar l-Cw alkyl-, C3-14cycloalkyl-Ci-e alkyl-, (5-14 membered heteroaryl)-C -g alkyl-, and (4-14 membered heterocycloalky 1)-Cw alkyl- of Ra4, Rc4, and Rd4are each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R11substituents;or, any Rc4and Rd4attached to the same N atom, together with the N atom to which they are attached, optionally form a 5- or 6-membered heteroaryd or a 4-14 membered heterocycloalkyl group, wherein the 5- or 6-membered heteroaryl or 4-14 membered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected R11substituents;each Rb4is independently selected from H, Ci-e alkyl, Ci- haloalkyl, C2-galkenyl, C2-galkynyl, Cg-u aryl,€3-14 cycloalky 1, 5-14 membered heteroaryl, 4-14 memberedheterocycloalkyl, Cg-u aryl-C i-g alkyl-,€3-14 cycloalkyl-Ci-6 alkyl-, (5-14 membered heteroaryl)-Ci-g alkyl-, and (4-14 membered heterocycloalky 1)-C R>alkyl-, wherein the CM alkyl, C2-g alkenyl, C2-g alkynyl, Cg-u aryl, CJ-Mcycloalkyl, 5-14 membered heteroaryl, 4-14membered heterocycloalkyl, Ce-u aryl-Ci-e alkyl-, Ci-u cycloalkyl-C -6 alky' 1-, (5-14 membered heteroaryl)-C]-6 alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6 alkyl- of RB4are each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected Rrisubstituents; each Re4is independently selected from H, OH, CN, C.-s alkyl, C.-s alkoxy, Ci-6haloalkyl, Ci-ehaloalkoxy, C2-6 alkenyl, C2-6 alkynyl, Ca-u aryl, C3-i4 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C6-i4 aiyl-Ci-6alkyl-, C3-14 cycloalky 1- Ci-f,alkyl-, (5-14 membered heteroar l) -C -6alkyl-, and (4-14 membered heterocycloalkyl)-C -6alkyl-;each Rf4and R8* is independently selected from H, C.-s alkyl, Ci«alkoxy, Ci-6haloalkyl, Ci-6haloalkoxy, C2-6 alkenyl, C2-6 alkynyl, CKaryl, C3U4 cycloalkyl, 5-14 membered heteroary l, 4-14 membered heterocycloalkyl, Ce-u ary l-Ci-6alkyl-, C3-14 cycloalky 1- C [-6 alkyl-, (5-14 membered he teroaryl)-Ci-6alkyl-, and (4-14 membered heierocyeloalkyli-Ci-6alkyl-;each Rh4and Rl4is independently selected from H, Ci.&alkyl, Ci.&haloalkyl, C2-6 alkenyl, C2-6 alkynyl, Ce-w aryl, Cj-w cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce- aryl-C 1.5 alkyl-, C3-14 cycloalky l-Ci-b alkyl-, (5-14 membered heteroaiyd)-Ci-6alkyl-, and (4-14 membered keterocycloalkyl)-C i-e alkyl-;each Rj4and R“4is independently selected from OH, Ci-ealkoxy, and C -ehaloalkoxy; or, any R|4and Rk4attached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-mem bered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from Ci-e alkyl and Ci-6haloalkyl;each RHis independently selected from D, halo, oxo, C [-6alkyl, C [-6haloalkyl, C2-6 alkenyl, C2-6 alkynyl, Ce-u aryl, Cs-ucycloalkyi, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-w ary l-Ci-6 alkyl-, C3-14 cycloalkyl-Ci-e alkyl-, (5-14 membered heteroaryl)-Ci-6 alkyl-, (4-14 membered heterocycloalkyl)-Ci-6 alkyl-, CN, NO2, OR35, SRa5, NI-IOR35, C(0)Rb5, C(0)NRc5Rd5, C(0)NRc5(0Ra5), C(0)0R35, 0C(0)Rbs, 0C(0)NRc5Rd5. NRc5Rd5, NRc5NRc5Rd5,NRc5C(0)Rbs, NRc5C(0)0R35, NRc5C(0)NRc5Rd5, C(=NReS)Rb5, C(=NRe5)NRc5Rd5, NRc5C(=NRe5)NRc5Rd5, NRc5C(=NRe5)Rb5, NRc5S(0)Rb5,NRc5S(0)NRc5Rd5, N R'SiOnR1". NRc5S(0)(-NRc5)Rb5, NRc5S(0)2NRc5Rd5, S(0)Rb5, S(0)NRc5Rci5, SiOj lC". S(0)2NRc5Rd5, 0S(0)(=NRe5)Rb5, 0S(0)2Rbs, SFs, P(0)RfiRgi, 0P(0)(0Rh5)(0Rl5), P(0)(0Ra5)(0R5), and BRj5Rk:, wherein the CMalkyl, C2-6alkenyl, C2-6 alkynyl, Ca-u aryl, C3-i4 cycloalkyl, 5-14 membered heteroaryl, 4-14 memberedheterocycloalkyl, C6-i4 aiyl-Ci-6alkyl-, Cs-u cycloalkyl-Ci-e alkyl-, (5-14 memberedheteroaryl)-C -6 alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6alkyl- of Rflare each optionally substituted with 1 , 2, 3, or 4 independently selected R1substituents;each Ra5, R°5, and Rdiis independently selected from H, C i-s alkyl, Ci-s haloalkyl, C2-6alkenyl, C2-Galkynyl, CG-Maryl, C3..14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, CG-Maryl-C i-e alkyl-, C3-i4 cycloalkyl-Ci-6 alkyl-, (5-14 membered heteroaryl)-Ci-6alkyl-, and (4-14 membered heterocycloalky 1)-CR>alkyl-, wherein the CMalkyl, C2-e alkenyl, C2-6alkynyl, CG-M aryd, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, CG-M aryl-C -6 alkyl-, C3- cycloalkyl-C -e alky' 1-, (5-14 membered heteroaryi)-Ci-6alkyl-, and (4-14 membered heterocycloalkyi)-C 1.6 alkyl- of Ra5, Rc>, and Rdsare each optionally substituted with 1, 2, 3, or 4 independently selected R1substituents;or any R05and Rdaattached to the same N atom, together with the N atom to winch they are attached, form a 5- or 6-membered heteroary l or a 4-14 membered heterocycloalkyl group, wirerein the 5- or 6-membered heteroaryl or 4-14 membered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected R!substituents;each Rtois independently selected from H, CJ-Galkyl, C2-6 alkenyl, C2-0 alky nyl, C6-i4 aryl, C3 -14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, CG-Maryl- Ci-f,alkyl-, C3-14 cycloalkyl-Ci-Galkyl-, (5-14 membered heteroary!)-Ci-e, alkyl-, and (4-14 membered heterocycloalky l)-Ci-6alkyl-, wirerein the Ci-e alkyl, C2-6alkenyl, C2-6 alkynyl, CG- 1 aryi, C3-1+cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloaikyi, CG-Maryi-Ci-e alkyl-, Cs-w cycloaikyl-Ci-Galkyl-, (5-14 membered heteroaryi)-Ci-s alkyl-, and (4-14 membered heterocycloalkyi)-CMGalkyl- of Rb5are each optionally substituted with 1, 2, 3, or 4 independently selected R1substituents;each Re5is independently selected from H, OH, CN, CI-G alkyl, Ci-e alkoxy, Ci-e haloalkyl, Ci-ehaloalkoxy, C2-Galkenyl, C2« alkynyl, CG-Maryl, C3-14cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloaikyi, Cs-14aryi-Ci-e alkyl-, C3-14 cycloalkyl- Ci-5 alkyl-, (5-14 membered heteroaryl)-Ci-6 alkyl-, and (4-14 membered heterocycloalkyl)-Ci- 6 alky 1-;each Rf5and R85is independently selected from H, Ci-e alkyl Ci-e alkoxy, C1-6 haloalkyl, Cwehaloalkoxy, C2-Galkeny l, C2-Galkynyl, CG-Maryl, C3-Mcycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloaikyi, CG- Mar l-C -6 alkyl-, Cs-Mcycloalkyi- Ci-6 alkyl-, (5-14 membered heteroaryl) -CI-Galkyl-, and (4-14 membered heterocycloalky 1)-Ci. 6 alkyi-;each R115and R15is independently selected from H, Ci-s alkyl, Ci-s haloalkyl, C2-e alkenyl, C2-6alkynyl, C&-J4 aryi, C3-cycloalkyl, 5-14 membered heteroary l, 4-14 memberedheterocycloalkyl, Ce-u ary i-Ci-6 alkyl-, C -i+ cycloalkyl-C -e alkyl-, (5-14 membered heteroaryl)-C]^ alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6 alkyl-;each RJiand R’° is independently selected from OH, C -s alkoxy, and C i-ehaloalkoxy; or, any Rjdand Rk5attached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from Ci-e alky l and Ci-6haloalkyl; each Rlis independently selected from D, halo, oxo, Ci-e alkyl, Ci-e haloalkyl, C2-6 alkenyl, C2-6 a!kynyl, Ce-u aryl, C -ir cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce- aryl-C i-dalkyl-, C3-1 cycloalky I-C1-6 alkyl-, (5-14 membered heteroarvd)-C 1-6 alkyl-, and (4-14 membered heteroeyeloaikyi)-C [-s alkyl-, CN, N02, ORa5,0P(0)(0Rh5)(0Rl6), P(0)(0Rb6)(0R16), and BRj6Rt6, wherein the C;,·. alkyl, ('·,·. alkenyl, ('·,·. alkynyl, Ci.-n aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4- 14 memberedheterocycloalkyl, Ce-14 ary i-Ci-6alkyl-, Ca-i+ cycloalkyl-C -e alkyl-, (5-14 membered heteroaryi)-Ci-6alkyl-, and (4-14 membered heterocycloalkyi)-C 1.6 alkyl- of R1are each optionally substituted with 1, 2, 3, or 4 independently selected RJsubstituents;each Ra6, Rcf>, and Rd6is independently selected from H, Ci-6alkyl, Ci-6haloalkyl, C2.6alkenyl, C2-&alkynyl, Ce-w aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-ir aiyl-Ci-6 alkyl-, Cs-u cycloalkyi-Ci-e alkyl-, (5-14 membered heteroaryl)-Ci.6alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6alkyl-, wherein the Che alkyl, C2-&alkenyl, C2-&alkynyl, CMaryl, Ci-Kcycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Cs-w aryl-Ci-6alkyl-, C3-14 cycloalky l-Ci-6 alkyl-, (5-14 membered heteroaryl)-Ci-6 alkyl-, and (4-14 membered heterocycloalkyl)-C ue alkyl- of Rao, Rc6, and Rd6are each optionally substituted with 1, 2, 3, or 4 independently selected RJsubstituents; or any RCRand Rd6attached to the same N atom, together with the N atom to which they are attached, form a 5- or 6-membered heteroaryl or a 4-14 membered heterocycloalkyl group, wherein the 5- or 6-membered heteroaryl or 4-14 membered heterocycloalkyl group is optionally substituted with 1 , 2, 3, or 4 independently selected R1substituents;each Rb6is independently selected from H, Ci-6alkyl, Cue haloalkyl, C2-6 alkenyl, C2-6 alkynyl, Ci.-n aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4- 14 memberedheterocycloalkyl, 65-14 ary 1-6 i-e alkyl-, C -i+ cycloalkyl-C -e alkyl-, (5-14 membered heteroaryl)-C]^ alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6 alkyl-, wherein the C -6 aikyi, C‘ alkenyl, C2-6 alkyny!, 65-14 aryl,€3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, 65-14 ar l-Cw alkyl-, C3-14 cycloalkyl-Ci-e alkyl-, (5-14 membered heteroaryl)-C]-6 alkyl-, and (4-14 membered heterocycloalky l)-C]-6 alkyl- of Rfc6are each optionally substituted with 1, 2, 3, or 4 independently selected RJsubstituents;each Re6is independently selected from H, OH, CN, Ci-e alkyl, Ci-e alkoxy, Ci-&haloalkyl, Ci-ehaloalkoxj', 62-5alkenyl, C2-6alkynyl, 65-14aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, 65-1aryl-6 i-s alkyl-, C3-14cycloalky 1- Ci-6alkyl-, (5-14 membered heteroaryl)-C]-6alkyl-, and (4-14 membered heterocycioalkyi)-Oi-6alkyl-;each Rf6and Rg6is independently selected from H, Ci-e alkyl, Ci-e alkoxy, Ci-&haloalkyl, Oi-ehaloalkoxy, C2-6 alkenyl, 62-5 alkynyl, 65-14 aryl, 63-14 cycloalkyl, 5-14 membered heteroaiyl, 4-14 membered heterocycloalkyl, 65-14 ary l-Ci-6alkyl-, C3..14 cycloalky 1- C i-6 alkyl-, (5-14 membered heteroaryi)-C i-s alkyl-, and (4-14 membered heterocycloalkyl)-6 i-6alkyl-;each Rh6and Rl6is independently selected from H, C -6alkyl,haloalkyl, C2-6 alkenyl, C2-6 alkynyl, 65-14 aryl, 63-14 cycloalkyl, 5-14 membered heteroaryi, 4-14 membered heterocycloalkyl, 65-1 aryl-61.5 alkyl-, C3-14 cycloalky l-Ci-6 alkyl-, (5-14 membered heteroaryl)-C 1-6 alkyl-, and (4-14 membered heteroeyeloalkyi)-O i-s alkyl-;each RJf>and R*6is independently selected from OH, Ci-ealkoxy, and Ci-ehaloalkoxy; or, any Rj6and Rkbattached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-membered heterocycloalky 1 group optionally substituted with 1, 2, 3, or 4 substituents independently selected from 61-5 alkyl and Ci-6 haloalkyl;each RJis independently selected from 13, halo, oxo, Ci-6 alkyl, 61-5 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, 65.14 aryl, 63-1 cycloalkyl, 5-14 membered heteroaryi, 4-14 membered heterocycloalkyl, 65-14 ar I-C1-& alkyl-, 63-14 cycloalkyl-Ci-6 alkyl-, (5-14 membered heteroaryl)-6]-6 alkyl-, and (4-14 membered heterocycloalkyl)-6i-6 alkyl-, 6N, NO2, ORa / , SRa?, NHOR87, 6(0)Rb7, 6(0)NRc7Rd7, 6(0)NRc7(QRa7), C(0)0R*7, 06(0)Rb7,0C(0)NRc7Rd7, NRc7Rd7, NRc7NRc7Rd7,NRc76(0)Rb7, NRc7C(0)0Ra7, NRc76(0)NRc7Rd7, C(=NRe7)Rb7, 6(=NRc7)NRc7Rd7, NRc76(===NRe7)NRc7Rd?, NRc76(===NRe7)Rb7, NRc7S(0)Rfc7, NRc7S(0)NRc7Rd7, NRc7S(0>2Rb7, NRc7S(0)(=NRe7)Rb7, NRc7S(0)2NRc7Rd7, S(0)Rb7, S(0)NRc7Rd7, S(0)2Rh7, S(0)2NRc7Rd?, 0S(0)(=NRe7)Rb7, 0S(0)2Rb75SFs, P(0)Ri7'Rg7, OPi OiiOR · is OR j. P(0)(0Rh7)(0R’7), and BR7Rk7, wherein the CM alkyl, 62,5 alkenyl, 62,5alkynyl, Ce- aryl, C3-i4 cycloalkyl, 5-14 membered heteroaryl, 4-14 memberedheterocycloalkyl, CM* aiyl-C [-6 alkyl-, C3-14 cycloalkyl-Cj-e alkyl-, (5-14 membered heteroaryd)-C 1-6 alkyl-, and (4-14 membered heteroeyeloaikyi)-C[-s alkyl- of RJare each optionally substituted with 1, 2, 3, or 4 independently selected RKsubstituents;each Ra7, Rc7, and Rdis independently selected from H, Cj-6alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6alkynyl, Ce-u aryl, C3-14cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, CM* ar I-C1-&alkyl-, C3-14cycloalkyl-Ci-e alkyl-, (5-14 membered heteroaryl)-C]-6alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6alkyl- wherein the C1-6 alkyl, C2-6alkenyl, C2« alkynyl, Ce-u aryl, C3-14cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl,€5-14 atyl-Ci-s alkyl-, C3-i4 cycloalkyl-C] -6 alkyl-, (5-14 membered heleroaryl)-C]-6 alkyl-, and (4-14 membered heterocy cloalkyl)-Ci-6 alkyl- of Ra', Rc / , and Rd?are each optionally substituted with 1, 2, 3, or 4 independently selected R substituents; or any Rc / and Rd7attached to the same N atom, together with the N atom to which they are attached, form a 5- or 6-membered heteroaryl or a 4-14 membered heterocycloalkyl group, wherein the 5- or 6-membered heteroaryl or 4-14 membered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected RKsubstituents;each Rb7is independently selected from H, Ci-e alkyl, Ci-e haloalkyl, C2-6 alkenyl, C2-6alkynyl, Ce- aryl, C3-14cycloalkyl, 5-14 membered heteroaryl, 4-14 memberedheterocycloalkyl, Ce- aryl-C1.5alkyl-, C3-14cycloalky I-C1-6 alkyl-, (5-14 membered heteroaryl)-C 1-6 alkyl-, and (4-14 membered heterocy cloaikyi)-Ci-6 alkyl-, wherein the Ci-s alkyl,€2-5 alkenyl, C2-s alkynyl, C&-14 aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C * aryl-Ci-e alkyl-, C3-34 cycloalkyl-Ci-s alkyl-, (5-14 membered heteroaryl)-Ci-6alkyl-, and (4-14 membered heterocycloaikyi)~C[-6alkyl- of R0 / are each optionally substituted with 1, 2, 3, or 4 independently selected RKsubstituents;each Rs' is independently selected from H, OH, CN, Ci-e alkyl, C2-6alkenyl, C1-6alkoxy, Ci.&haloalkyl, Cj-shaloalkoxy, C2-6 alkynyl, Ce-i aryl, C3-1cycloalkyl, 5-14 membered heteroaryl, and 4- 14 membered heterocycloalkyl;each Rf?and Rg / is independently selected from H, Ci-e alkyl, Cue alkoxy, Ci-e haloalkyl, C;i-f!haloalkoxy, C2-6 alkenyl, C2-6alkynyl, Ce-w aryl, C3-14cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-w aryl-Cj-6alkyl-, Cs-w cycloalkji- Ci-6alkyl-, (5-14 membered heteroaryl) -C1-6alkyl-, and (4-14 membered heterocycloalky 1)-Ci.&alkyd-;each Rh?and R1' is independently selected from H, Ci-6alkyl, Cj^ haloalkyl, C2-6 alkenyl, C2-f, alkynyl, GM4 aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 memberedheterocycloalkyl, Ce-u ary l-Ci-6 alkyl-, C -i+cycloalkyl-C -e alkyl-, (5-14 membered heteroaryl)-C]^ alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6 alkyl-;each Rj7and Rk' is independently selected from OH, C -salkoxy, and Ci-ehaloalkoxy; or, any Rj' and Rk / attached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from Ci-e alky l and Ci-b haloalkyl;each R is independently selected from H, D, OH, halo, oxo, CN, C(0)0H, NH2, NO2, SFs, C -6alkyl, C -e alkoxy, Ci-ehaloalkoxy, C--6haloalkyl, C2-6 alkenyl, C2-6 alkynyl, Ce¬l and, C3.14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloaikyi, Ce-ir aryl-Ci-6alkyl-, CVw cycloalkyl-Ci-e alkyl-, (5-14 membered heteroaryl)-Ci-6alkyl-, and (4-14 membered heterocycloalky l)-Ci-6alkyl-; andwherein any heteroaryl group of any of the above-recited substituents optionally comprises an N-oxide on any ring-forming nitrogen.In some embodiments,each RJis independently selected from 13, halo, oxo, Ci-6alkyl, Ci-6haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C&.14 aryl, C3-1cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloaikyi, CMar I-C1-&alkyl-, C3-14 cycloalkyl-Ci-e alkyl-, (5-14 memberedheteroaryl)-C]-6alkyl-, and (4-14 membered heterocydoalkyl)-Ci-6 alkyl-, CN, NO2, ORa / , SRa7, N i !OlC . C(0)Rb7, C(0)NRc7Rd7, C(0)NRc7(0Ra7). C(0)0R*7, 0C(0)Rb7,0C(0)NRc7Rd7, NRc7Rd7, NRc7NRc7Rd7,NRc7C(0)Rb7, NIC ( (0)010 NRc7C(0)NRc7Rd7, C(==NRe7)Rb7, C(=NRe7)NRc7Rd7, NRc7C(===NRe7)NRc7Rd7, NRc7C(=NRe7)Rb7, NRc7S(0)Rb7, NRc7S(0)NRc7Rd7, N R SiOi -R' . NRc7S(0)(-NRe7)Rb7, NRc7S(0)2NRc7Rd7, S(0)Rb7,S(0)NRc7Rd7, S(0)2Rb7, S(0)2NRc7Rd?, 0S(0)(=NRe7)Rb7, 0S(0)2Rb7, SFs, P(0)Ri7Rg7, OPi OxOR1:M OR i. P(0)(0Rh?)(0R7), and HR- Rk;each Ra', Rc', and Rd' is independently selected from H,€1-5 alkyl, C -6haloalkyl, C2-6 alkenyl, C2-6alkynyl, C&.14aryl, C3-1cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloaikyi, CMaryl-Ci^, alkyl-, C3-14cycloalkyl-Ci-e alkyl-, (5-14 memberedheteroaryl)-C]-6alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6 alkyl-;or any Rc' and Rd / attached to the same N atom, together with the N atom to which they are attached, form a 5- or 6-membered heteroaryl or a 4-14-membered heterocycloaikyi group; andeach Rb / is independently selected from H, Cj-6 alkyl, Cj-6 haloalkyl, C2-6alkenyl, C2-6alkynyl, Ce-u aryl, 6(3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 memberedheterocycloalkyl, Ce-w ary i-Ci-6 alkyl-, C -i+ cycloalkyl-C -e alkyl-, (5-14 membered heteroaryl)-C]^ alkyl-, and (4-14 membered heterocycloa3kyl)-Ci-6 alkyl-.In some embodiments,each R1is independently selected from D, halo, oxo, C .-s alkyl, C .-s haloaikyl, C2.6alkenyl, C2-6 alkynyl, Ce-w aryl, Cj-w cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyi, Ce-ir aiyl-Ci-6 alkyl-, Cs-u cycloalkyl-Ci-e alkyl-, (5-14 membered heteroaryl)-Ci-6alkyl-, and (4-14 membered heterocycloalkyl)-C [-6alkyl-, CN, NO2, ORa6, SRa6, NHORa6, C(0)Rb6, C(0)NRc6Rd6, C(0)NRc6(0Ra6), C(0)ORa6, OC(0)Rb6,GC(0)NRc6Rd6, NRc5Rd6, NRc6NRc6Rd6, NRc6C(0)Rfc6, NRc6C(0)ORaf>, NRc6C(0)NRc5Rd6, C(=NRe6)Rb6, C(=NRe6)NRc6Rd6, NRc6C(=NRe6)NRc6Rd6, NRc6C(=NRe6)Rb6, NRc6S(0)Rb6, NRc6S(0)NRc6Rd6, NRc6S(0)2Rb5, NRc6S(0)(=NRe6)Rb6, NRc6S(0)2NRc6Rd6, S(0)Rb6, S(0)NRc6Rd6, S(0)2Rb6, S(0)2NRc6Rd6, 0S(0)(=NRe6)Rb6, 0S(0)2Rb6, SF5, P(0)Rf6Rg6, 0P(0)(0Rh6)(0Rl5), P(0)(0Rh6)(0Rl6), and BRj6Rk6;each Ra6, Rc6, and R'fois independently selected from H, Ci-e alkyl, Ci-e haloaikyl, C2-6alkenyl, C2-6alkynyl, Ce-w aryl, Cj-w cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyi, Ce- aryl-C1.5alkyl-, C3-14cycloalky I-C1-6alkyl-, (5-14 membered heteroaryl)-Ci^ alkyl-, and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-;or any R06and Rdoattached to the same N atom, together with the N atom to which they are attached, form a 5- or 6-membered heteroaryl or a 4-14-membered heterocycloalkyi group; andeach Rbois independently selected from H, C -6alkyl, C -6haloaikyl, C2.&alkenyl, C2-&alkynyl, Ce-w aryl, C3-14cycloalkyl, 5-14 membered heteroaryl, 4-14 memberedheterocycloalkyi, Ce-ir aiyl-Ci-6 alkyl-, Cs-u cycloalkyi-Ci-e alkyl-, (5-14 membered heteroaryl)-Ci.6 alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6 alkyl-.In some embodiments, each Rhis independently selected from D, halo, oxo, C -6alkyl, Ci-6 haloaikyl, C2-e alkenyl, C2-6 alkynyl, CN, Ci.& alkoxy, Ci-b haloalkoxy, amino, Ci-6 alkylamino, di-Ci -s alkylamino, Cw, alkylsulfonyl, aminosulfonyl, C -6aikyiaminosulfonyi, di-Ci-6alkylaminosulfonyl, and C -6alkylsulfonylamino; wherein said Cl -6 alkyl is optionally substituted by 1, 2, 3, 4, 5, 6, 7, or 8 independently selected halogens.In some embodiments, each R35, R°, and Rd:’ is independently selected from H, Ci-6alkyl, Ci« haloaikyl, C2-6 alkenyl, C« alkynyl, phenyl, C3-7 cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyi, phenyl-Ci-e alkyl-, Crw- cyeloalkyi-Ci-e alkyl-, (5-6 membered heteroaryi)-C i-6alkyl-, and (4-7 membered heterocycloalkyl)-C]-6alkyl-, wherein the Ci-6alkyl, C2-6alkenyl, C2-&alkynyl, phenyl, C3-?cycloalkyl, 5-6 membered heteroaryl, 4-7membered heterocycloalkyl, phenyl-Ci-e alkyl-, C3-7 cycloalky l-Ci-e alkyl-, (5-6 membered heteroaryi)-C -6 alkyl-, and (4-7 membered heterocycloalky 1)-CMalk l- of RaS, Rc5, and R®are each optionally substituted with 1, 2, 3, or 4 independently selected R1substituents;each Rtois independently selected from H, C alkyl, C haloalkyl, C2-6 alkenyl, C2-6 alkynyl, phenyl, C3-7 cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C i-6alkyl-, C3-7cycloalkyl-Ci-e alkyl-, (5-6 membered heteroaryl)-Ci-6alkyl-, and (4-7 membered heterocycloalky 1)-CMalkyl-, wherein the Ci-e alkyl, C2-6 alkenyl, C2-6 alkynyl, phenyl, C3-7 cycloalkyl, 5-6 membered heteroaryi, 4-7 membered heterocycloalkyl, phenyl-Ci-6alkyl-, Cfr cycloalkyl-CMalkyl-, (5-6 membered heteroaryl)-Ci-6alkyl-, and (4-7 membered heterocycloalkyl)-C i-6alkyl- of RB:’ are each optionally substituted with 1, 2, 3, or 4 independently selected R!substituents;each R5is independently selected from H, OH, CN, C , alkyl, CM, alkoxy, CM, haloalkyl, and CMhaioalkoxy;each Rftand R83is independently selected from H, CMalkyl, CMhaloalkyl, C2-6 alkenyl, C2-6 alkynyl, phenyl, C3-7cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-Ci-6 alkyl-, C3-7 cycloalky I-CMalkyl-, (5-6 membered heteroaryl)-Ci- 6 alkyl-, and (4-7 membered heterocycloalkyi)-CMalkyl-;each Rtoand R15is independently selected from H, CMhaloalkyl, C alkyl, C2-6alkenyl, C2-6 alkynyl, phenyl, C3-7cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C -6 alkyl-, C3-7 cycloalky 1-C alkyl-, (5-6 membered heteroaryl)-Cj- 6 alkyl-, and (4-7 membered heterocycloalky 1)-OMalkyl-;each Rj5and R*5is independently selected from OH, CMalkoxy, and Ci^haloalkoxy; andeach R1is D, halo, oxo, CMalkyl. CMhaloalkyl, CS-s alkenyl, C2-Salkynyl, CN, CMalkoxy, Ci-6haioalkoxy, amino, CMalkylamino, di-CMalkylamino, C -6alkylsulfonyl, aminosulfonyl. CMalkylaminosulfonyl, di-CMalkylaminosulfonyl, and CMa!ky!su!i:bny!amino.In some embodiments, each R!and R3is independently selected from D, halo, oxo, CMalkyl, CMhaloalkyl, C2-6 alkenyl, C2-6 alkynyl, CN, CMalkoxy. C , haioalkoxy, amino, Ci-6 alkylamino, di-CMalkylamino, CMalkylsulfonyl, aminosulfonyl. CMalkylaminosulfonyl, di-CMalkylaminosulfonyl, and CMalkylsulfonylamino; andeach RKis independently selected from H, D, OH, halo, oxo, CN, C(0)GH, NH2,NO2, SFs, CM alkyl CMalkoxy, CMhaioalkoxy, CMhaloalkyl, C2-6 alkenyl, and C2-6 alkynyl.In some embodiments:X is N;R1is selected from H, Ci-6alkyl, C i-s haloalkyl, C2-6 alkenyl, C2-6alkynyl, Ce-u axyl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-u aryl-Cns alkyl-, C3- .4 cycloalkyl-C 1-6 alkyl-, (5-14 membered heteroaryi)~Cj-6alkyl-, (4-14 membered heterocycloalkyl)-C i-6alkyl-, GR3i, C(0)Rbl, C(0)NRclRdl, C(0)0Ral, C(=NReI)Rbl, C(=NRel)NRclRdl, S(0)Rw, S(0)NRciRd, Si O) Rh i. and S(0)2NRclRdl, wlierein the C]-5alkyl, C2-6 alkenyl, C2-6 alkynyl, Ce-w aryl, Cj-w cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Cs-w aryl-Ci-6alkyl-, C3-14 cycloalk l-Ci-6 alkyl-, (5-14 membered heteroarv4)-C 1-6 alkyl-, and (4-14 membered heteroeyeloalkyl)-C [-s alkyl- of R1are each optionally substituted with 1 , 2, 3, 4, 5, 6, 7, or 8 independently selected Rasubstituents;R2is selected from H, D, halo, Ci-6alkyl, Ci-6haloalkyl, C2-6 alkenyl, C2-6 alkynyl, Ce- 14 a d,€3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-ir aryi-Ci-6 alkyl-, C3 -14 cycloalkyl-C 1-6 alkyl-, (5-14 membered heieroaryl)-Ci-6alkyl-, (4-14 membered heterocycloalkyl)~Ci-6 alkyl-, CN, N02, OR32, SR32, NHOR32, C(0)Rb2,C(0)NRe2Rd2, C(0)NRc2(0Ra2), C(0)QR32, 0C(0)Rb2, 0C(0)NRc2Rd2. NRe¾d2,NRc2NRc2Rd2, NRc2C(0)Rb2, NRc2C(0)0R32, NRc2C(0)NRc2Rd2, C(=NRe2)Rb2,C(=NRe2)NRc2Rd2, NRc2C(=NRe2)NRc2Rd2, NRc2C(=NRe2)Rb2, NRc2S(0)NRc2Rd2,\ R'2S;OiRh. N R2S{0)!7 N R Si ()}{ N R'"iRh. NRc2S(Q)2NRc2Rd2, S(G)Rb2,S(0)NRc2Rd2, S(0)2Rb2, S(0)2NRc2Rd2, 0S(0)(=NRe2)Rb2, 0S(0)2Rb2, SFs, P^R*2, 0P(0)(0Rb2)(0Rl2), P(0)(0Rh2)(0Rl2), and HR- R1'2. wherein the CMalkyl, C2.6alkenyl, C2.„ alkynyl, Ce-w aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 memberedheterocycloalkyl, Ce-i aiyl-Ci-6 alkyl-, Cs-u cycloalkyl-Ci-e alkyl-, (5-14 membered heteroaryl)-Ci-6 alkyl-, and (4-14 membered heterocycioalkyl)-C½alkyl- of R2are each optionally substituted with 1 , 2, 3, 4, 5, 6, 7, or 8 independently selected Rcsubstituents;Cy1is C-6-14 aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, or 4-14 membered heterocycloalkyl, wherein the Cg-w aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, or 4-14 membered heterocycloalkyl is optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected Rhsubstituents;provided that when Cy1is 4-14 membered heterocycloalkyl, then the 4-14 membered heterocycloalkyl of Cy1is other than unsubstituted morpholinyl;provided that Cy1is not pyridin-4-yl optionally substituted with 1, 2, 3, or 4 independently selected R' substituents;provided that Cy1is not pyrimidin-4-yl optionally substituted with 1, 2, or 3, independently selected Rfcsubstituents;provided that Cy1is not quinolin-4-yl optionally substituted with 1, 2, 3, 4, 5, or 6 independently selected R substituents;Cy2is Ce-Maryl, CB-Mcycloalkyl, 5-14 mem bered heteroaryl, or 4-14 membered heterocycloalkyl, wherein the Ce-u aryl, C3-14cycloalkyl, 5-14 membered heteroaryl, or 4-14 membered heterocycloalkyl is optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R1'substituents;each Ral, Rcl, Rd!, Ra2, Rc2, and Rd2is independently selected from H, Cw alkyl, Cw haloalkyl, C2-6 alkenyl, C2-6 alkynyl, CM4 aryl, Cs-wcycloalkyl, 5-14 membered heteroaryl, 4- 14 membered heterocycloalkyl, C 4 aryl-Ci-6 alkyl-, C3-14 cycloalkyl-Ci-e alkyl-, (5-14 membered he ternary l)-Ci-&alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6alkyl-, wherein the C]-6alkyl, C2-6 alkenyl, C2-6 alkynyl, Ce-u aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C&.14 aryl-Ci-6 alkyl-, C3-14 cycloalky 1-Cw alkyl-, (5-14 membered heteroaryl) -Cs-6 alkyl-, and (4-14 membered heterocycloalkyl)-C]-6 alkyl- of Rai, Rcl, Rd], Raz, R°2, and Rd2are each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R&substituents;or, any Rcland Rdiattached to the same N atom, together with the N atom to which they are attached, form a 5- or 6-membered heteroaryl or a 4-14 membered heterocycloalkyl group, wherein the 5- or 6-membered heteroaryl or 4-14 membered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected R<Jsubstituents;or any Rc2and Rd2attached to the same N atom, together with the N atom to which they are attached, form a 5- or 6-membered heteroaryl or a 4-14 membered heterocycloalkyl group, wherein the 5- or 6-membered heteroaryl or 4-14 membered heterocycloalkyl group is optionally substituted with 1 , 2, 3, or 4 independently selected R ' substituents;each Rbiand Rb2is independently selected from H, C.-s alkyl, C.-s haloalkyl, C2-6 alkenyl, C2-6 alkynyl, CM4 aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-w ary i-C 1-6 alkyl-, Cj-Hcycloalkyl-Cj-e alkyl-, (5-14 membered heteroaryl)-C]-6 alkyl-, and (4-14 membered heterocycloa3kyl)-Ci-6 alkyl-, wherein the Cj-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C&-34 aryl,€3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 4 aryl-Cw alkyl-, C3-14 cycloalkyl-Ci-e alkyl-, (5-14 membered heteroaryl)-C]-6alkyl-, and (4-14 membered heterocycloalky l)-Ci-6alkyl- of Rfci, Rb2, and Rb3are each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected Rusubstituents;each Rsland Re2is independently selected from H, OH, CN, CM alkyl, Ci-s alkoxy,C i-b haloalkyl, Ci-ehaloalkoxy, C2-6 alkenyl, C2-6 alkynyl, Ce-w aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl,€6- aryl-Cj-6alkyl-, Cs-u eyeloalkyi- Ci-6alkyl-, (5-14 membered heteroaryl) -C1-6 alkyl-, and (4-14 membered heterocycloalky 1)-Ci.&alkyl-;each Rcand Rg2is independently selected from H, C --6alkyl, Ci-e alkoxy, Ci-6haloalkyl, Ci-ehaloalkoxy, C2-6 alkenyl, C2-6 alkynyl, Ci.-n aryl, C3-14 cycloalky 1, 5-14 membered heteroary l, 4-14 membered heterocycloalkyl, CM4 ary l-Ci-6alkyl-, C3-14 cycloalky 1- Ci-dalkyl-, (5-14 membered heteroaryl)-Ci-6 alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6alkyl-;each Rh2and Rl3is independently selected from H, Ci-s alkyl, Ci^ haloalkyl, C2-6 alkenyl,€2-6 alkynyl, Ce-w aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-i aiyl-Ci-6 alkyl-, Cs-u cycloalkyi-Ci-e alkyl-, (5-14 membered heteroaiyl)-Ci-6alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6alkyl-;each Rj2and R*2is independently selected from OH, Cj-s alkoxy, and Ci-ehaloalkoxy; or any Rj2and Rk2attached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from Ci-e alkyl and C 1-6 haloalkyl;each Rb, Rc, Rr. RF, and RGis independently selected from D, halo, oxo, Ci-b alkyl, Ci-6haloalkyl, C2-6 alkenyl, C2-6 alkynyl,€6- ·4 aryl, C3-1 cycloalkyd, 5-14 membered heteroaryl, 4-14 membered heterocycloalky 1, C&.14 ary l-Ci-6 alkyl-, C3-14 cycloalky 1-Cw alkyl-, (5-14 membered heteroaryl)-Ci-f,alkyl-, (4-14 membered heterocycloalkyi)-Ci-f,alkyl-, CN,0P(0)(0Rb4)(0R14), P(0)(0RM)(0Ri4), and BRj+Rk4, wherein the Ci-6alkyl, C2-6 alkenyl, C2-6alkynyl, Ce-w aryl, C3-Mcycloalkyl, 5-14 membered heteroaryd, 4-14 memberedheterocycloalkyl, Ce-i4 aryl-Cs-6alkyl-, Cs-Meycloalkyi-Ci-e alkyl-, (5-14 membered heteroaryl)-Ci.6alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6alkyl- of RB, Rc, RE, RF, and R&are each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected RHsubstituents;each Ra+, Rc4, and Rd4is independently selected from H, Ci-e alkyl, Ci-e haloalkyl, C2-6 alkenyl, C2-6 alkynyl, Ce-w aryl, C3-14 cycloalkyl, 5-14 membered heieroaryl, 4-14 membered heterocycloalkyl, Ce-w aryl-C -6 alkyl-, Cs-w eyeloalkyi-Ci-e alkyl-, (5-14 membered heteroaryl)-Ci.6alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6alkyl-, wherein the Ci-e alkyl, C2-6 alkenyl, C2-6 alkynyl, CVw aryl,€3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-u aryi-C -e alkyl-, Cs-w cycloalky l-Ci-6 alkyl-, (5-14 membered heteroaryl)-Ci-6 alkyl-, and (4-14 membered heterocycloalkyl)-C i-e alkyl- ofR84, Rc4, and Rd4are each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected Rhsubstituents;or, any Kc+and Ra4attached to the same N atom, together with the N atom to which they are attached, optionally form a 5- or 6-membered heteroaryl or a 4-14 membered heterocycloalkyl group, wherein the 5- or 6-membered heieroaryl or 4-14 membered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected RHsubstituents;each RMis independently selected from H, Ci-e alkyl, Ci-e haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C&-14 aryl, C3-14 cycloalkyl, 5-14 membered heieroaryl, 4-14 memberedheterocycloalkyl, Ce-n ary I-C1-&alkyl-, C3-14 cycloalkyl-Ci-e alkyl-, (5-14 membered heteroaryl)-C]-6alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6 alkyl-, wherein the C -e alkyl, C2-6 alkenyl, C2-6 alkynyl, C&.14 aryl, C3-14 cycloalkyl, 5-14 membered heieroaryl, 4-14 membered heterocycloalkyl, Cs-w aryl-Ci-e alkyl-, CVw cycloalkyl-Ci-e alkyl-, (5-14 membered heteroaryl)-Ci.6alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6alkyl- of Rb4are each optionally substituted with 1 , 2, 3, 4, 5, 6, 7, or 8 independently selected RHsubstituents; each Re4is independently selected from H, OH, CN, Ci-e alkyl, Ci^ alkoxy, Ci-e haloalkyl, Ci-ghaloalkoxy, C2-6 alkenyl,€2-5 alkynyl, CG-Maryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-u axyl-Ci-e alkyl-, C3-14 cycloalkyl- Ci-dalkyl-, (5-14 membered heteroaryrl)-Ci-6 alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6alky 1-;each Rf4and Rs‘!is independently selected from H, Ci-e alkyl, Ci-ealkoxy, Ci-e haloalkyl, Ci-ehaloalkoxy, C2-6 alkeny l, C2-6 alkynyl, Ce-w aiyl, C3-Wcycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-w ary!-Cs-e alkyl-, Cs-w cycloalkyi- Ci-6alkyl-, (5-14 membered heteroaryl)-Ci-6alkyl-, and (4-14 membered heterocycloalky 1)-Ci.&alkyd-;each Rh4and R'4is independently selected from H, C -b alkyl, C -b haloalkyl, C2-6 alkenyl, C2-6 alkynyl, Cf.-u aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 memberedheterocycloalkyl, Ce-w aryi-Ci-e alkyl-, C -i+ cycloalkyl-C -e alkyl-, (5-14 membered heteroaryl)-C]-6 alkyl-, and (4-14 membered heterocycloaikyl)-Ci-6 alkyl-;each RJdand Rk4is independently selected from OH, C -s alkoxy, and C i-ehaloalkoxy; or, any Rj4and Rk4attached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from Ci-e alkyl and Ci-6haloalkyl; each RHis independently selected from D, halo, oxo, Ci-6alkyl, Cw haloalkyl, C2-6alkenyl, C2-6 alkynyi, Ce-u aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-u aryl-Ci-e alkyl-, C3-1cycloalky l-Ci-b alkyl-, (5-14 membered heteroaryl)-C 1-6 alkyl-, (4-14 membered heterocycloalky l)-Ci-6 alkyl-, CN, NO2, OR35, SR35,0P(0)(0Rh5)(0Rl5), P(0)(0Rbi)(0R15), and BRj5Rk5, wherein the C;,·. alkyl, ('·,·. alkenyl, ('·,·. alkynyi, C&-J4 aryl, CB-Ucycloalkyl, 5-14 membered heteroaryl, 4- 14 memberedheterocycloalkyl, Ce-w aryl-Ci-6alkyl-, C3-i4 cycloalkyl-Ci-6 alkyl-, (5-14 membered heteroaryl)-Ci-6alkyl-, and (4-14 membered heterocycloalky 1)-C 1.6 alkyl- of RHare each optionally substituted with 1, 2, 3, or 4 independently selected R:substituents;each Ra\ Rc5, and Rdbis independently selected from H, Ci-6alkyl, Ci-6haloalkyl, C2-6alkenyl, C2-f,alkynyi, Ce-w aryl, C3-14cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-i aiyl-Ci-6 alkyl-, Cs-Hcycloalkyi-Ci-e alkyl-, (5-14 membered heteroatyl)-Ci-6alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6alkyl-, wherein the C1.6 alkyl, C2-6alkenyl, C2-6 alkynyi, Ce-w aryl, Ci-Kcycloalkyl, 5-14 membered heteroaryd, 4-14 membered heterocycloalkyl, Cs-w aryl-Ci^ alkyl-, C3-14cycloalky l-Ci-6 alkyl-, (5-14 membered heteroaryl)-Ci-6 alkyl-, and (4-14 membered heterocycloalkyl)-C ½ alkyl- of R35, Rc5, and R*35are each optionally substituted with 1, 2, 3, or 4 independently selected R!substituents; or any RcSand Rd5attached to the same N atom, together with the N atom to which they are attached, form a 5- or 6-membered heteroaryl or a 4-14 membered heterocycloalkyl group, wherein the 5- or 6-membered heteroaryl or 4-14 membered heterocycloalkyl group is optionally substituted with 1 , 2, 3, or 4 independently selected R1substituents;each Rb5is independently selected from H, C -6alkyl, Cue haloalkyl, C2-6alkenyl, C2-6 alkynyi, C&-J4 aryl, CB-Ucycloalkyl, 5-14 membered heteroaryl, 4- 14 memberedheterocycloalkyl, Ce-u aryl-Ci^ alkyl-, Cs-ir cycloalkyl-C -e alkyl-, (5-14 membered heteroaryl)-C]-6 alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6 alkyl-, wherein the CM alkyl, C2-6 alkenyl, C2-6alkymyl, C&-14aryl,€3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-u aryl-Cw alkyl-, C3-14cycloalkyl-Ci-e alkyl-, (5-14 membered heteroaryl)-Ci-6 alkyl-, and (4-14 membered heterocycloalky 1)-CM alkyl- of Rb5are each optionally substituted with 1, 2, 3, or 4 independently selected R1substituents;each Re5is independently selected from H, OH, CN, CM alkyl, Ci-s alkoxy, Ci-&haloalkyl, Ci-ehaioalkoxy, C2-6 alkenyl, C2-6 alkynyl, Ce- aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-u aryl-Ci-e alkyl-, C3-1 cycloalky 1- C -e alkyl-, (5-14 membered heteroaryl)-C]-6alkyl-, and (4-14 membered heterocycloalkyi)-C -6alkyl-;each Reand R is independently selected from H, Cue alkyl, Ci-e alkoxy, Ci-&haloalkyl, C -ehaloalkoxy, C2-6 alkenyl, C2-6 alkynyl, Ce-u aryi, C3-Mcycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-u ary l-Ci-6alkyl-, C3..14 cycloalky 1- C i-6 alkyl-, (5-14 membered heteroaryl)-C i-s alkyl-, and (4-14 membered heterocycloalkyl)-C i-6alkyl-;each Rh5and Rl5is independently selected from H, C -6alkyl,haloalkyl, C2-6 alkenyl, C2-6 alkynyl, Ce-u aryd, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-u aryl-C 1.5 alkyl-, C3-1 cycloalky l-Ci-b alkyl-, (5-14 membered heteroaryl)-C 1-6 alkyl-, and (4-14 membered heterocyeloaikyi)-C i-6 alkyl-;each RJdand Rk5is independently selected from OH, Ci-e alkoxy, and Ci-ehaloalkoxy; or, any Rj5and R^ attached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-membered heterocycloalky 1 group optionally substituted with 1, 2, 3, or 4 substituents independently selected from CM alkyl and Ci-6haloalkyl;each R1is independently selected from 13, halo, oxo, CM alkyl, CM haloalkyl, C2-6alkenyl, C2-6alkynyl, C&.14aryl, C3-14cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-u ary I-C1-& alkyl-, C3-14cycloalkyl-Cw alkyl-, (5-14 membered heteroaryl)-C]-6 alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6 alkyl-, CN, NO2, ORao, SRa6, NHOR85, C(0)Rb6, C(0)NRc6Rd6, C(0)NRc6(QRafr), C(0)0R36, OC(Q)Rb6,(X (O)N R- R!:\ NRc6Rd6, NRc6NRc6Rd6, NRc6C(0)Rb6, NRc6C(0)0Ra6, NRc6C(0)NRc5Rd6, C(===NRe6)Rb6, C(==NRe6)NRc6Rd6, NRc6C(===NRe6)NRc6Rdf>, NRc6C(===NRe6)Rb6, NRc6S(0)Rb6,NRc6S(0)NRc6Rd6, NRc6S(0)2Rb6, NRc6S(0)(=NRe6)Rb6, NRc6S(0)2NRc6Rd6, S(0)Rb6, S(0)NRc6Rd6, S(0)2Rb6, S(0)2NRe6Rd6, 0S(0)(=NRe6)Rb6, 0S(0)2Rb6, SFs, P(0)Rf5Rg5,0P(0)(0Rh6)(0Rl6), P(0)(0Rn6)(0R6), and BR,6Rk6, wherein the CM, alkyl, C?,6alkeny l, C2-6alkynyl, Ce- aryl, C3-i4 cycloalkyl, 5-14 membered heteroaryl, 4-14 memberedheterocycloalkyl, CM* aiyl-C -6 alkyl-, C3-14 cycloalkyl-Cj-e alkyl-, (5-14 membered heteroaryd)-C 1-6 alkyl-, and (4-14 membered heteroeyeloaikyl)-C -s alkyl- of R1are each optionally substituted with 1, 2, 3, or 4 independently selected RJsubstituents;each R3b, Rc6, and Rd6is independently selected from H, C -6alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6alkynyl, Ce-u aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, CM* ar I-C1-&alkyl-, C3-14 cycloalkyl-Ci-e alkyl-, (5-14 membered heteroaryl)-C]-6alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6alkyl-, wherein the C -e alkyl, C2-6 alkenyl, C2-6 alkynyl, C&.34 aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Cs-w aryi-C -e alkyl-, CVw cyctoalkyl-Ci-e alkyl-, (5-14 membered heleroaryl)-C -6 alkyl-, and (4-14 membered heterocy cloalkyl)-Ci-6 alkyl- of R36, Rc5, and Rd6are each optionally substituted with 1, 2, 3, or 4 independently selected RJsubstituents;or any Rc6and Rdf>attached to the same N atom, together with the N atom to which they are attached, form a 5- or 6-membered heteroaryl or a 4-14 membered heterocycloalkyl group, wherein the 5- or 6-membered heteroaryl or 4-14 membered heterocycloalkyl group is optionally substituted with i, 2, 3, or 4 independently selected RJsubstituents;each Rb6is independently selected from H, Ci-e alkyl, Ci-e haloalkyl, C2-6 alkenyl, C2-6 alkynyl, Ce- aryd, C3-i4 cycloalkyl, 5-14 membered heteroaryl, 4-14 memberedheterocycloalkyl, Ce- aryl-C 1.5 alkyl-, C3-14 cycloalky I-C1-6 alkyl-, (5-14 membered heteroaryl)-C 1-6 alkyl-, and (4-14 membered heterocyeloalkyl)-Ci-s alkyl-, wherein the Ci-s alkyl,€2-5 alkenyl, C2« alkynyl, C&-14 aryd, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C * aryl-Ci-e alkyl-, C3-u cycioalkyl-Ci-s alkyl-, (5-14 membered heteroaryi)-Ci-6alkyl-, and (4-14 membered heterocycloaikyi)~C[-6alkyl- of R00are each optionally substituted with 1, 2, 3, or 4 independently selected RJsubstituents;each R86is independently selected from H, OH, CN, Cj-6alkyl, Ci-e alkoxy, Cw haloalkyl, Ci-ehaloalkoxy, C2.6alkenyl, C2-6alkynyl, Ce-w aryl, C3-14 cycloalkyl, 5-14 membered heteroasyl, 4-14 membered heterocycloalkyl, CM* ary l-Ci-6 alkyl-, C3-i4 cycloalky 1- Ci-6alkyl-, (5-14 membered heteroaryl)-Ci-6alkyl-, and (4-14 membered heterocycloaiky{)~Ci-6alkyl-;each Rfband Rg5is independently selected from H, Ci-6alkyl, C -e alkoxy, Ci-e haloalkyl, Ci-ghaloalkoxy, C2-6alkenyl, C2« alkynyl, Ce-n aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-u aryl-Ci-e alkyl-, C3-14 cycloalkyl- Ci-6alkyl-, (5-14 membered heteroaiyli-Ci-g alkyl-, and (4-14 membered heterocycloalkyil-C -6alkyl-;each Rhoand Rl5is independently selected from H, C aikyi, C haloalkyl, C2-6 alkenyl, C2-6 alkynyl, Ce-w aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, (M-Maryl-CMalkyl-, Cs-Mcycloa kyi-CMalkyl-, (5-14 membered heteroaryl)-Ci.6 alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6 alkyl-;each Rj6and RK6is independently selected from OH, C -salkoxy, and Ci-shaloalkoxy; or, any Rj6and Rkf>attached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from C alkyl and CMhaloalkyl;each RJis independently selected from D, halo, oxo, CMalkyl, CMhaloalkyl, CMalkenyl, CMalkynyl, C&-Karyl, C-t-u cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-w aryl-CMalkyl-, C - cycloalkyl-C -e alkyl-, (5-14 memberedheteroaryl)-C]-6 alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6 alkyl-, CN, NO2, OR3', SRa7, NHORa7, C(0)Rb7, C(0)NRc7Rd7, C(0)NRc7(0Ra7), C(0)0Ra7, 0C(0)Rb7,0C(0)NRc7Rd7, NRc7Rd7, NRc7NRc7Rd7,NRc7C(0)Rb7, NRc7C(0)QRa7, NRc7C(G)NRc7Rd7, C(=NRe7)Rb7, C(=NRe7)NRc7Rd7, NRc7C(=NRe7VNRc7Rd7, NRc7C(=NRe7)Rb7, NRc7S(0)Rb7, NRe7S (0)NRc?Rd?, N R'SiOi -R1'. NRc7S(0)(=NRe7)Rb7, NRc7S(0)2NRc7Rd7, S(0)Rb7,S(0)NRc7Rd7, SsOi -R· . S(0)2NRc7Rd7, 0S(0)(=NRe7)Rb7, 0S(0)2Rb7, SF5, P;OiR'Rf . OlhOHOR · )(OR !. P(0)(0Rh7)(0Rl7), and HR Rk. wherein the CMalkyl, CMalkenyl, C2-6 alkynyl, C&.14 aryl, C3-14 cycloalkyl, 5-14 membered heteroaryd, 4-14 memberedheterocycloalkyl, Ce-i4 aryl-Cj-e alkyd-, CN-Meycloalkyi-Ci-e alkyl-, (5-14 memberedheteroaiyl)-Ci-6alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6alkyl- of RJare each optionally substituted with 1 , 2, 3, or 4 independently selected R substituents;each Ra', Rc / , and Rd / is independently selected from H, CMalkyl, CMhaloalkyl, CMalkenyl, C2-s alkynyl, C&-14 aryd, C3..14cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-u aryl-CMalkyl-,€3-14 cycloalkyl-CMalkyl-, (5-14 memberedheteroaryl)-Ci-6 alkyl-, and (4-14 membered heterocycloalky 1)-CMalkyl- wherein the CMalkyl, C2-6 alkenyl, C2-6 alkynyl, Ce-w aryl, C -u cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-u aryl-C -e alkyl-, CS-Mcycloalky 1-CMalkyl-, (5-14 membered heteroaryi)-CMalkyl-, and (4-14 membered heterocycloalkyl)-Ci-6alkyl- of Ra / , Rc', and Rd' are each optionally substituted with 1, 2, 3, or 4 independently selected RKsubstituents; or any Rc / and Rd' attached to the same N atom, together with the N atom to which they are attached, form a 5- or 6-membered heteroaryl or a 4-14 membered heterocycloalkyl group, wherein the 5- or 6-membered heteroaryl or 4-14 membered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected RKsubstituents;each Rb / is independently selected from H, Ci-6alky l, Ci-6haloalkyl, C2-6 alkenyl, C2-6 alkynyl, Ce-w aryl, C3-Hcycloalkyl, 5-14 membered heteroaryi, 4-14 memberedheterocycloalkyl, CX-w aryl-Cs-6alkyl-, Cs-w eyeloalkyi-Ci-e alkyl-, (5-14 membered heteroaiyl)-Ci-6alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6alkyl-, wherein the C1.6 alkyl, C2-6 alkenyl, C2-6 alkynyl, CV14aryl, Ci-Kcycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-u aryl-C -e alkyl-, CS-Mcycloalky l-Ci-6 alkyl-, (5-14 membered heteroaryl)-Ci-6alkyl-, and (4-14 membered heierocycloalkyl)-C ue alkyl- of Rs?are each optionally substituted with 1 , 2, 3, or 4 independently selected R substituents;each Re' is independently selected from H, OH, CN, Cue alkyl, C2-6 alkenyl, Ci-e alkoxy, Ci^ haloalkyl, Cwhaloalkoxy, C2-6 alkynyl, CM* aryl, Cs-wcycloalkyl, 5-14 membered heteroaryi, and 4-14 membered heterocycloalkyl;each R^ and Rs' is independently selected from H, Ci-e alkyl, C [-6 alkoxy, Ci-&haloalkyl, C -ehaloalkoxy, C2-6 alkenyl, C2-6 alkynyl, Ce-u aryi, C3-Hcycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-i4 ar l-Ci-6 alkyl-, C3..14 cycloalky 1- C i-6 alkyl-, (5-14 membered heteroaryl)-Ci-s alkyl-, and (4-14 membered heterocycloalkyl)-Ci- 6 alkyl-;each Rh7and R1' is independently selected from H, C -6alkyl,haloalkyl, C2-6 alkenyl, C2-6 alkynyl, Ce-u aryd, C3-14 cycloalkyl, 5-14 membered heteroaryi, 4-14 membered heterocycloalkyl, Ce- aryl-C 1 -5 alkyl-, C3-14 cycloalky l-Ci-6 alkyl-, (5-14 membered heteroaryl)-C 1-6 alkyl-, and (4-14 membered heterocycloalkyi)-Ci-s alkyl-;each RJ' and RK / is independently selected from OH, Ci-&alkoxy, and Ci-ehaloalkoxy; or, any Rj7and Rk' attached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-membered heterocycloalky 1 group optionally substituted with 1, 2, 3, or 4 substituents independently selected from Ci-e alkyl and C 1.6 haloalkyl;each RKis independently selected from H, D, OH, halo, oxo, CN, C(0)OH, NH2,NO2, SF5, CI-6 alkyl, Ci-6 alkoxy, Ci-ehaloalkoxy, Ci-e haloalkyl, C2-6 alkenyl, C2.6 alkynyl, Ce- 14 aryl, C3-34 cycloalkyl, 5-14 membered heteroaryi, 4-14 membered heterocycloalky 1, Ce-i4 aryl-Ci-6alkyl-, C3-14 cycloalkyl-Ci-6alkyl-, (5-14 membered heteroaiyl)-Ci_6 alkyl-, and (4-14 membered heterocycloalky3)-Ci-6alkyl-; andwherein any heteroaryi group of any of the above-recited substituents optionally comprises an N-oxide on any ring-forming nitrogenin some embodiments;X is N;R1is selected from H, CVe alkyl, C2-6 alkenyl, C2-6 alkynyl, and Cw haloalkyl;R2is selected from H, D, halo, Ci-s alkyl, Ci-s haloalkyl, C2-6 alkenyl, C2-6 alkynyl, Ce- i4 aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, CC-Maryl-Ci-6 alkyl-, CVw cyctoalkyl-Ci-e alkyl-, (5-14 membered heteroaryi)~Ci-6 alkyl-, (4-14 membered heterocycloalky 1)-Ci.5alkyl-, CN, N02, OK"'. SR w M IOR" . C(0)Rb2,C(0)NRc2Rd2, C(0)NRc2(0Ra2), C(0)0Ra2, 0C(0)Rb2, 0C(0)NRc2Rd2, NRc2Rd2,NRe2NRc2Rd2, NRc2C(0)Rb2, NRc2C(0)0Ra\ NRc2C(0)NRc2Rd2, C(=NRe2)Rb2,C(=NRe2)NRc2Rd2, NRc2C(=NRe2)NRc2Rd2, NRc2C(=NRe2)Rb2, NRc2S(0)NRc2Rd2,NRc2S(0)Rb2, NRc2S(0)2Rb2, NRc2S(0)(=NRe2)Rb2, NRc2S(0)2NRc2Rd2, S(0)Rb2,SiOjN R· R;i. S(0)2Rb2, S(0)2NRc2Rd2, 0S(0)(=NRe2)Rb2, 0S(0)2Rb2, SF5, P(0)RfiR82, OP OXOR^XQR12), P(0)(0R!I2)(0R12), and BRj3Rk2, wherein the C -e alkyl, C2-6 alkenyl, C2-6 alkynyl, Ce- aryl, C3-i4 cycloalkyl, 5-14 membered heteroaryl, 4-14 memberedheterocycloalky 1, CM* aiyri-C i-b alkyl-, C3-14 cycloalkyl-Cj-e alkyl-, (5-14 membered heteroaryl)-Ci-6alkyl-, and (4-14 membered heterocycloalkyl)-C 1-6 alkyl- of R2are each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected Rcsubstituents;Cy1is CW4 aryl, CJ-Mcycloalkyl, 5-14 membered heteroaryl, or 4-14 membered heterocycloalkyl, wherein the CS-Maryl, C3-i4cycloalkyl, 5-14 membered heteroaryl, or 4-14 membered heterocycloalkyl is optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R11or RMsubstituents;provided that when Cy1is 4-14 membered heterocycloalkyl, then the 4-14 membered heterocycloalkyl of Cy1is other than unsubstituted morpholinyl;Cy2is C&-14 aryl, C3-i4cycloalkyl, 5-14 membered heteroaryl, or 4-14 membered heterocycloalky 1, wherein the C5-14 aryl, C3-] 4cycloalkyl, 5-14 membered heteroaryl, or 4-14 membered heterocycloalkyl is optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected Rrsubstituents;each R32, Rc2, and Rd2is independently selected from H, Ci-b alkyl, Ci-b haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C&.14 aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, CM* ary I-C1-&alkyl-, C3-14 cycloalkyl-Ci-e alkyl-, (5-14 membered heteroaryl)-C]-6alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6alkyl-, wherein the C -e alkyl, C2-6 alkenyl, C2-&alkynyl, Ce-w aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, CX-w aryl-Ci-e alkyl-, CVw cyctoalkyl-Ci-e alkyl-, (5-14 membered heteroaryl)-Ci.6alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6alkyl- of R3, Rc2, and Rd2are each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R&substituents;or any Rc2and Rd2attached to the same N atom, together with the N atom to which they are attached, form a 5- or 6-membered heteroaryl or a 4-14 membered heterocycloalkyl group, wherein the 5- or 6-membered heteroaryl or 4-14 membered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected R° substituents;each Rb2is independently selected from H, Cue alkyl. Cue haloalky!, C2-6 alkenyl, C2-6 aikynyl, Ce-u aryl, C3-Hcycioalkyi, 5-14 membered heteroaryl, 4-14 memberedheterocycloalkyl, C w ar I-C1-&alkyl-, C3-14 cycloalkyl-Cw alkyl-, (5-14 membered heteroaryl)-C]-6alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6 alkyl-, wherein the Cj-e alkyl, C2-6 alkenyl, C2-6 aikynyl, C&.34 aryl, C3-1 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C6-Haryl-Ci-e alkyl-, CVw cyctoalkyl-Ci-e alkyl-, (5-14 membered heteroaryl)-C]-6alkyl-, and (4-14 membered heterocy cloalkyl)-Ci-6alkyl- of Rb2are each optionally substituted with 1 , 2, 3, 4, 5, 6, 7, or 8 independently selected R&substituents; each Reis independently selected from H, OH, CN, Ci-e alkyl, Cue alkoxy, Ci-e haloalkyl, Ci-ehaloalkoxy, C2-6 alkenyl,€2-5 aikynyl, Ce-ir aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, CM4 axyl-Ci-e alkyl-, C5-14 cycloalkyl- Ci-dalkyl-, (5-14 membered heteroaryl)-Ci-6 alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6alkyl-;each R12and Rg2is independently selected from H, Ci-e alkyl, Cue haloalkyl, Ci-e alkoxy, Ci.&haloalkyl, Cj-shaloalkoxy, C2-6 alkenyl, C2-6 aikynyl, Cs-ir aryl, Csur cycloalkyl, 5-14 membered heteroaiyl, 4-14 membered heterocycloalkyl, CS-Haryl-C 1-6 alkyl-, C3- 14 cycloalkyl-C 1-6 alk l-, (5-14 membered heteroaryl)-Ci-6alkyl-, and (4-14 membered heterocycloalky l)-Ci-6alkyl-;each R12and Ri ;is independently selected from H, Cj-e alkyl, Cj-e haloalkyl, C2-6 alkenyl, C2-6 aikynyl, C&-14 aryd, C3..14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-u aryl-C i-e alkyl-, C3-i4cycloalkyl-Cj-6alkyl-, (5-14 membered heteroaryl)-Ci-6alkyl-, and (4-14 membered heterocycloalky l)-Ci-6alkyl-;each RJand RKis independently selected from OH, C3-6 alkoxy, and Ci-ghaloalkoxy; or any R'2and RKattached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from Cj-6alkyl and Cj-6haloalkyl;each Rc, RE, RM, R\ and R° is independently selected from D, halo, oxo, C--6alkyl, Ci-e haloalkyl, C2-6 alkenyl, C2-6 aikynyl, CS-Maryd, C3- 14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-n ar l-C] -6alkyl-, Cs-ircycioalkyl-Ci-e alkyl-, (5-14 membered heteroaryl)-C i-6alkyl-, (4-14 membered heterocy cloalkyl)-C [-6alkyl-, CN,0P(0)(0RM)(0Ri4), P(0)(0Rb4)(0R14), and BRj4Rt4, wherein the Ci Aalkyl, ('·,·. alkenyl, ('.,·. alkynyl, C&-J4 aryl, CB-Ucycloalkyl, 3-14 membered heteroaryl, 4- 14 memberedheierocycloalkyi, Ce-w ary' l-Ci-6alkyl-, Ca-i+ cycloalkyl-Cj-e alkyl-, (5-14 membered heteroaryl)-Ci-6 alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6 alkyl- of Rc, RE, RM, R", and R° are each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected Rhsubstituents;each Ra+, Rc4, and Rd4is independently selected from H, Cj-6alkyl, Cj-6haloalkyl, C2-6alkenyl, C2-6alkynyl, C&-14 aryl, C3-u cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-w ar l-Ci-6 alkyl-, C3-14 cycloalkyl-Ci-e alkyl-, (5-14 membered heteroaryl)-Ci-6alkyl-, and (4-14 membered heterocycloalkyi)-Cs-6alkyl-, wherein the Cj-6alkyl, C2-6 alkenyl, C2-6 alkynyl,€5-14 aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C -r ary 1-Cw alkyl-, C3-Mcycloalky l-Ci-6 alkyl-, (5-14 membered heteroaryl)-Cj-6 alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6 alkyl- of Ra4, Rc4, and Rd4are each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R'1substituents;or, any Rc4and Rd4attached to the same N atom, together with the N atom to which they are attached, optionally form a 5- or 6-membered heteroaryl or a 4-14 membered heterocycloalkyl group, wherein the 5- or 6-membered heteroaryl or 4-14 membered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected Rrisubstituents;each Rb4is independently selected from H, Ci-e alkyl, Ci-e haloalkyl, C2-6 alkenyl, C2« alkynyl, C&-J4 aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4- 14 memberedheierocycloalkyi, Ce-14 ary' 1-C 1-6 alkyl-, Ca-i+ cycloalkyl-Cj-e alkyl-, (5-14 membered heteroary l)-Cj-6alkyl-, and (4-14 membered heterocycloalky l)-Ci-6alkyl-, w'herein the Cj-6alkyl, C2-6alkenyl, C2-6alkynyl, C&-14 aryl, Cs-i+ cyeloalkyi, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, CS-Mar l-Cw alkyl-, C3-14 cycloalky 1-C 1-6 alkyl-, (5-14 membered heteroaryl)-Cj-6 alkyl-, and (4-14 membered heterocycloalkyl)-Cj-6 alkyl- of Rb4are each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R11substituents;each R84is independently selected from H, OH, CN, CM alky l, C -e alkoxy, CM haloalkyl, C;i-f!haloa3koxy, C2-6 alkenyl, C2-6 alkynyl, Ce-w aiyl, C3-Wcycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl,€6- aryl-C -6alkyl-, Cs-u eyeloalkyi- Ci-6alkyl-, (5-14 membered heteroaryl) -C1-6 alkyl-, and (4-14 membered heterocycloalky 1)-Ci.&alkyl-;each Rf4and Rg4is independently selected from H, CM alkyl, Ci-e alkoxy, C haloalkyl, C -ehaloalkoxy, C2-6 alkenyl, C2-6 alkynyl, (M-M aryl, C3-14cycloalky 1, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, CM 4 ary l-Ci-6alkyl-, C3-14cycloalky 1- CM alkyl-, (5-14 membered heteroaryl)-C alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6alkyl-;each RMand R14is independently selected from H, CM alkyl, CM haloalkyl, C2-6 alkenyl, C2-6 alkynyl, Ce-w aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-ir aiyl-Ci-6 alkyl-, Cs-u cycloalkyl-Ci-e alkyl-, (5-14 membered heteroaryl)-Ci.6 alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6 alkyl-;each Rj4and RK4is independently selected from OH, C -s alkoxy, and Ci-shaloalkoxy; or, any RJ+and Rk4attached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from Ci-e alkyl and C M haloalkyl;each RHis independently selected from D, halo, oxo, CM alkyl, CM haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C&-K aryl, C-t-u cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-w ary l-Ci-6 alkyl-, C3-14 eyeloalkyl-Cw alkyl-, (5-14 membered heteroaryl)-C].s alkyl-, (4-14 membered heterocycloalky l)-Ci-6 alky!-, CN, NO2, OR3, SR®5,0P(0)(0Rbi)(0Rl5), P(0)(0Rh5)(0Rl5), and H - R1'". wherein the CM alkyl, CM alkenyl, C2-6 alkynyl, Ce-w aryl, C3-Hcycloalkyl, 5-14 membered heteroaryl, 4-14 memberedheterocycloalkyl, C6-i4 aryl-CMalkyl-, C3-i4 cycloalkyl-Ci-6 alkyl-, (5-14 membered heteroaiyl)-Ci-6 alkyl-, and (4-14 membered heterocycloalkyl)-C½alkyl- of Rhare each optionally substituted with 1 , 2, 3, or 4 independently selected R1substituents;each R35, R°5, and Rd5is independently selected from H, CM alkyl, CM haloalkyl, C2-6 alkenyl, C2-6 alkynyl, Ci.-u aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 memberedheterocycloalkyl, Ce-w ary i-Ci-e alkyl-, Cj-i+cycloalkyl-Cj-e alkyl-, (5-14 membered heteroaryl)-C]^ alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6 alkyl-, wherein the Cj-6 aikyi, C‘ alkenyl, C2-6 alkyny!, C&-Karyl,€3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Cg-n ar l-Cw alkyl-, C3-14 cycloalkyl-Ci-e alkyl-, (5-14 membered heteroaryl)-C]-6alkyl-, and (4-14 membered heterocycloalky l)-C -6alkyl- of Ra5, Rc\ and Rd5are each optionally substituted with 1, 2, 3, or 4 independently selected R!substituents;or any Rc5and Rdsattached to the same N atom, together with the N atom to which they are attached, form a 5- or 6-membered heteroaryl or a 4-14 membered heterocycloalkyl group, wherein the 5- or 6-membered heteroaryl or 4-14 membered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected R:substituents;each Rtois independently selected from H, Cj-g alky l, C2-6 alkenyl, C2-6 alkynyl, Cg- 14 aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Cg-w aryl- Ci-6alkyl-, Cs-u cycloalkyl-Ci-g alkyl-, (5-14 membered heteroaryl)-Ci-6alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6alkyl-, wherein the Ci-g alkyl,€2-5 alkenyl, C2-6 alkynyl, Cg. 14 aryd, Cs-w cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, CS-Maryl-Ci-6 alkyl-, C3.14 cycloalky -Ci-g alkyl-, (5-14 membered heteroaryl)-Ci-6 alkyl-, and (4-14 membered heterocycloalkyl)-C 1-6 alkyl- of Rtoare each optionally substituted with 1, 2, 3, or 4 independently selected R!substituents;each Reis independently selected from H, OH, CN, Ci-e alkyl, Ci-e alkoxy , Ci-g haloalkyl, Cj-ghaloalkoxy, C2-6 alkenyl, C2-6 alkynyl, Cg-u aryl, Ca-s cycloalkyl, 5-14 membered heteroaiyl, 4-14 membered heterocycloalkyl, Cg-14 aryl-Ci-6alkyl-, C3..14 cycloalky 1- C [-6 alkyl-, (5-14 membered he teroaiyl)-Ci-6alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6alkyl-;each Rftand R83is independently selected from H, Ci-g alkyl, Ci-6alkoxy, Ci-g haloalkyl, Ci-ghaloalkoxy, C2-6 alkenyl, C2-6 alkynyl, Ca-u aryd, C3-i4 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalky 1, Cg.44 aryl-Ci-g alkyl-, C3-14 cycloalky 1- Ci-f,alkyl-, (5-14 membered heteroaryl) -Ci-g alkyl-, and (4-14 membered heterocycloalkyl)-Cj-6alkyl-;each Rtoand R'5is independently selected from H, Ci-6alkyl, Ci-6haloalky l, C2-6 alkenyl, C2-6alkynyl, Cg-k aryl, C-t-u cycloalkyl, 5-14 membered heteroaiyl, 4-14 membered heterocycloalkyl, Ce-w ary l-Ci-6 alkyl-, C3-14 cycloalkyl-Cw alkyl-, (5-14 membered heteroaryl)-C]-6alkyl-, and (4-14 membered heterocycloalkyl)-C]-6alkyl-;each R·'5and Rkiis independently selected from OH, Cj-g alkoxy, and Ci-ghaloalkoxy;or, any Rj5and Rk?' attached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from C -6alkyl and C -6haloalkyl; each R1is independently selected from D, halo, oxo, C .-s alkyl, C .-s haloalkyl, C2-6 alkenyl, C2-6 alkynyl, Ce-w aryl, CB-Hcycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-ir aiyl-Ci-6 alkyl-, Cs-u cycloalkyi-Ci-e alkyl-, (5-14 membered heteroarvd)-Ci-6 alkyl-, and (4-14 membered heterocycloalkyl)-C -6 alkyl-, CN, NO2, ORa6,0P(0)(0Rh6)(0Rl6), P(0)(0Rh6)(0R16), and BR¾k6, wherein the CMalkyl, C2-6alkenyl, C2.6alkynyl, C&-14 aryl, C3-1+ cycloalk l, 5-14 membered heteroaryl, 4-14 memberedheterocycloalkyl, Ce-u aryl-C i-e alkyl-, CB-i4cycloalkyl-Ci-6 alkyl-, (5-14 membered heteroaryl)-Ci-6alkyl-, and (4-14 membered heterocycloalky 1)-C 1.6 alkyl- of R1are each optionally substituted with 1, 2, 3, or 4 independently selected RJsubstituents;each R86, Rcf>, and Rd6is independently selected from H, C -b alkyl, C -b haloalkyl, C2-6 alkenyl, C2-e alkynyl, C<5-i4aryl, C3-1 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-i4 aryl-C -e alkyd-, Cs-w cycloalkyi-Ci-e alkyl-, (5-14 membered heteroaryl)-Ci-6alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6alkyl-, wherein the Ci-e alkyl, C2-&alkenyl, C2-&alkynyl, Ce-w aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-u aryl-C -e alkyl-, CS-Mcycloalky l-Ci^ alkyl-, (5-14 membered heteroaryl)-Ci-6alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6alkyl- of R3R, Rc5, and Rd6are each optionally substituted with 1 , 2, 3, or 4 independently selected R1substituents; or any Rcoand Rd6attached to the same N atom, together with the N atom to which they are attached, form a 5- or 6-membered heteroaryl or a 4-14 membered heterocycloalkyl group, wherein the 5- or 6-membered heteroary l or 4-14 membered heterocycloalkyl group is optionally substituted with 1 , 2, 3, or 4 independently selected RJsubstituents;each Rfc5is independently selected from H, Cue alkyl. Cue haloalkyl, C2-6alkenyl, C2-&alkynyl, C&-14aryl,€3-14cycloalky 1, 5-14 membered heteroaryl, 4-14 memberedheterocycloalkyl, Ce-u aryl-Ci-e alkyl-,€3-14cycloalkyl-Ci-6alkyl-, (5-14 membered heteroaryl)-Ci-6 alkyl-, and (4-14 membered heterocycloalky 1)-C R, alkyl-, wherein the CM alkyl, C2-e alkenyl, C2-e alkynyl, C&-J4 aryl, CJ-Mcycloalky 3, 5-14 membered heteroaryl, 4-14membered heterocycloalkyl, Ce-u aryl-C -e alkyl-, C3-i4 cycloalkyl-CMalkyl-, (5-14 membered heteroaryl)-C]^ alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6alkyl- of Rb6are each optionally substituted with 1, 2, 3, or 4 independently selected RJsubstituents;each Re6is independently selected from H, OH, CN, CMalkyl, C .-s alkoxy, Ci-6haloalkyl, CMhaloalkoxy, C2-6 alkenyl, C2-&alkynyl, Ce-u aryl, C3-i4 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-i4 aiyl-Ci-6alkyl-, C3-i4 cycloalkyl- Ci-f,alkyl-, (5-14 membered heteroaryl)-C]-6alkyl-, and (4-14 membered heterocycloalkyl)-C -6alkyl-;each R®and Rg6is independently selected from H, Cm, alkyl, Ci-ealkoxy, Ci-6haloalkyl, Ci-6haloalkoxy, C2-6 alkenyl, C2-6alkynyl, CKaryl, C3-i4 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, CM4 aryl-C alkyl-, C3-i4 cycloalky 1- C -6 alkyl-, (5-14 membered heteroaryl)-C alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6alkyl-;each Rh6and R5is independently selected from H, C alkyl, CMhaloalkyl, C2.6alkenyl, CMalkynyl, Ce-w aryl, Cj-w cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-u aryl-C1-5 alkyl-, C3-14cycloalky l-Ci-6 alkyl-, (5-14 membered heteroar l)-Ci-6 alkyl-, and (4-14 membered keterocycloalkyl)-C M alkyl-;each RJf>and Rk5is independently selected from OH, Ci-e alkoxy, and C -ehaloalkoxy; or, any R|6and Rk6attached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-mem bered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from CMalkyl and Ci-6haloalkyl;each RJis independently selected from D, halo, oxo. CM alkyl. CM haloalkyl, CM alkenyl, CMalkynyl, Ce-u aryl, C3-u cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-w ary 1-CMalkyl-, C3-14 eyeloalkyl-CMalkyl-, (5-14 membered heteroaryl)-CMalkyl-, and (4-14 membered heterocycloalkyi)-Cs-6 alkyl-, CN, N02, ORa7, SR' . NHORa7, C(0)Rb7, C(0)NRc7Rd7, C(0)NRc7(0Ra7). ( (OiOR . 0C(0)Rb7,0C(0)NRc7Rd7, NRc7Rd7, NRc7NRc7Rd7,NRc7C(0)Rb7, NRc7C(0)0Ra7, NRc7C(0)NRc7Rd7,('; N R;)Rb. C(=NRe7)NRc7Rd7, NRc7C(=NRe7)NRc7Rd7, N R'C( \ R;)Rh. NRc7S(0)Rb7, NRc7S(0)NRc7Rd?, N R Si Oi -R1'. NRc7S(0)(=NRe7)Rb?, NRc7S(0)2NRc7Rd7, S(0)Rb7, S(0)NRc7Rd7, S(0) .R!'. S(0)2NRc7Rd70S(0)(=NRe7)Rb7, 0S(0)2Rb7, SFs, P;OiR'R / . OP(0)(ORb,)(OR! / ), P(0)(ORh / )(ORi 7), and BRJ / Rk / , wherein the CMalkyl, CMalkenyl, CMalkynyl, Ce-u atyl, C3-i4 cycloalkyl, 5-14 membered heteroaryd, 4-14 memberedheterocycloalkyl, Ce-ir aryl-Ci-6alkyl-, CN-u cycloalkyi-Ci-e alkyl-, (5-14 memberedheteroaryl)-C]-6 alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6alkyl- of RJare each optionally substituted with 1 , 2, 3, or 4 independently selected R substituents;each Ra / , R0', and Rd7is independently selected from H, C i-s alkyl, C i-s haloalkyl, C2-6alkenyl, C2-6alkynyl, C&-14 aryl, C3..14cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-u aryl-C i-e alkyl-, C3-i4cycloalkyl-Ci-6 alkyl-, (5-14 membered heteroaryl)-Ci-6alkyl-, and (4-14 membered heterocy cloalky 1)-CR>alkyl- wherein the Ci-e alkyl, C2-6alkenyl, C2-f,alkynyl, Ce-w aryl, C3-i4 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-u aryl-Cj-e alkyl-, C3-i4 cycloalky l-Ci-6 alkyl-, (5-14 membered heteroaryi)-Ci-6alkyl-, and (4-14 membered heterocy cloalky i)-Ci-6alkyl- of Ra / , Rc', and Rd' are each optionally substituted with 1, 2, 3, or 4 independently selected RKsubstituents; or any R0?and Rd / attached to the same N atom, together with the N atom to which they are attached, form a 5- or 6-membered heteroary l or a 4-14 membered heterocycloalkyl group, wherein the 5- or 6-membered heteroaryl or 4-14 membered heterocy cloalky! group is optionally substituted with 1, 2, 3, or 4 independently selected RKsubstituents;each Rb / is independently selected from H, Cj-6alkyl, Cj-6haloalkyl, C2-s alkenyl, C2-6 alkynyl, C&.14aryl, C3-14cycloalkyl, 5-14 membered heteroaryl, 4-14 memberedheterocycloalkyl, CMary I-C1-&alkyl-, C3-14cycloalkyl-Ci-e alkyl-, (5-14 membered heteroaryl)-C]-6alkyl-, and (4-14 membered heterocy cloalkyl)-Ci-6 alkyl-, wherein the Cj-e alkyl, C2-6 alkenyl, C2-6 alkynyl, C&.14aryl, C3-14cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Cs-w aryi-Cj-6alkyl-, CVw cy cloalky 1-C i-s alkyl-, (5-14 membered heteroaryl)-Ci-6alkyl-, and (4-14 membered heterocycloalkyl)-C 1.6 alkyl- of Rb?are each optionally substituted with 1 , 2, 3, or 4 independently selected R substituents;each Re' is independently selected from H, OH, CN, Ci-e alkyl, C2_6 alkenyl, C5-6 alkoxy, Ci-b haloalkyl, Cwhaloalkoxy, C2-6 alkynyl, Ce-w aryl, C3-14cycloalkyl, 5-14 membered heteroaryl, and 4-14 membered heterocycloalkyl;each Rf / and Rg?is independently selected from H, C .-s alkyl, Ci« alkoxy, Ci-e haloalkyl, Cj-ehaloalkoxy, C2-6 alkenyl, C2-e alkynyl, C&-J4 aryl, Cji-u cy cloalkyi, 5-14 membered heteroary l, 4-14 membered heterocycloalkyl, CM4 ary' i-C 1-6 alkyl-, C3-i4 cyc!oalky 1- C i-6alkyl-, (5-14 membered he teroarydi-Ci-f, alky!-, and (4-14 membered heterocycloalkyl)-Ci-6alkyl-;each Rh / and R1' is independently selected from H, Ci-6 alkyl, Ci-6 haloalkyl, C2.6 alkenyl, C2-6 alkynyl, Ce-w aryl,€3-14 ey cloalkyi, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-ir aiyl-Ci-6 alkyl-, Cs-u cycloalky!-Ci-e alkyl-, (5-14 membered heteroaryd)-Ci-6 alkyl-, and (4-14 membered heterocycloalkyl)-C i-6 alkyl-;each RJ' and RK / is independently selected from OH, Ci-ealkoxy, and Ci^haloalkoxy; or, any RJ / and Rk' attached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-mem bered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from Cue alkyl and Ci-ehaloalkyl;each RKis independently selected from H, D, OH, halo, oxo, CN, C(0)QH, NH2,NO?, SFS, CWalkyl, Ci-ealkoxy, Ci-ehaloalkoxy, Ci-ehaloalkyl, C2-e alkenyl, C2-&alkynyl, C<s- i4aryl, C3-34 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-u aryl-Ci-6alkyl-, Cs-Kcycloalkyl-Ci-g alkyl-, (5-14 membered heteroarylVC -e alkyl-, and (4-14 membered heterocycloalkyl)-Ci..6 alkyl-; andwherein any heteroaryl group of any of the above-recited substituents optionally comprises an N -oxide on any ring-forming nitrogen.In some embodiments:X is N;R1is selected from H, Ci-b alkyl, C2-6 alkenyl,€2-6 alkynyl, and Ci-6haloalkyl;R2is selected from H, 13, halo, Ci-s alkyl, Ci-s haloalkyl, C2-e alkenyl, C2-6 alkynyl, Cs- 14 and, C3.14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-r aryl-Ci-6alkyl-, C3-14 cycloalkyl-C ue alkyl-, (5-14 membered heteroaiyl)-Ci-6 alkyl-, (4-14 membered heterocycloalky l)-C -6 alkyl-, CN, N02, ORaz, SR32, NHORa2, C(0)Rb3,C(0)NRc2Rd2, C(0)NRC2(0R32), C(0)0R32, 0C(0)Rb2, 0C(0)NRc2Rd2. NRc2Rd2,NRc2NRc2Rd2, NRc2C(0)Rb2, NRC2C(0)0R32, NRc2C(0)NRc2Rd2, C(=NRe2)Rb2,C(=NRe2)NRc2Rd\ NRc2C(=NRe2)NRc2Rd2, NRc2C(=NRe2)Rb2, NRc2S(0)NRc2Rd2,NRc2S(0)Rb2, NRc2S(0)2Rb2, NRc2S(0)(=NRe2)Rb2, NRc2S(0)2NRc2Rd2, S(0)Rb2,S(0)NRc2Rd2, S(0)2Rh2, S(0)2NRe2Rd2, 0S(0)(=NRe2)Rb2, 0S(0)2RM, SFs, P(0)RfiRg2, 0P(0)(0Rh2)(0Rl2), P(0)(0R“)(0Ri2), and BR2Rk2, wherein the CMalkyl, C2.6alkenyl, CMalkynyl, Ca-u aryl, Cb-w cyeloalkyl, 5-14 membered heteroaryl, 4-14 memberedheterocycloalkyl, Ce- aryd-C 1.5 alkyl-, C3-14 cycloalky l-Ci-e alkyl-, (5-14 membered heteroaryd)-Ci-6alkyl-, and (4-14 membered heterocycloalkyl)-C ue alkyl- of R2are each optionally substituted with 1 , 2, 3, 4, 5, 6, 7, or 8 independently selected Rcsubstituents;Cy1is Ce-14aryl, C3-14 cycloalkyl, or 5-14 membered heteroaryl, wherein the CC-Maryl, C3-14 cycloalkyl, or 5-14 membered heteroaryd is optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R or RMsubstituents;Cy2is CM* aryl, C3-14 cycloalkyl, 5-14 membered heteroaryd, or 4-14 membered heterocycloalkyl, wherein the Ce-u aryl, C3-14 cycloalkyl, 5-14 membered heteroaryd, or 4-14membered heterocycloalkyl is optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected Rbsubstituents;each R“, R°2, and Rtl2is independently selected from H, C i-s alkyl, C i-s haloalkyl, C2-6alkenyl, C2-s alkynyl, C&-14 aryd, C3..14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-u aryl-C i-e alkyl-, C3-i4cycloalkyl-Cj-6alkyl-, (5-14 membered heteroaryl)-Ci-6alkyl-, and (4-14 membered heterocycloalky 1)-CR, alkyl-, wherein the CMalkyl, C2-6 alkenyl, C2-6alkynyl, Ci.-u aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyi, Cs-u aryl-Ci-e alkyl-,€3-54 cycloalkyl-Ci-g alky' 1-, (5-14 membered heteroaryl)-Ci-6alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6alkyl- of Ra2, Rc, and Rdiare each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R° substituents;or any Rc2and Rd2attached to the same N atom, together with the N atom to which they are attached, form a 5- or 6-membered heteroaryl or a 4-14 membered heterocycloalkyi group, wherein the 5- or 6-membered heteroaryl or 4-14 membered heterocycloalkyi group is optionally substituted with 1 , 2, 3, or 4 independently selected R^1substituents;each Rb2is independently selected from H, Cj-6alkyl, Cj-6haloalkyl, C2.&alkenyl, C2-&alkynyl, Ci.-n aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 memberedheterocycloalkyi, Ce-w ary' l-Ci-6 alkyl-, Cs-i+cycloalkyl-Cj-e alkyl-, (5-14 membered heteroaryl)-Ci-6alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6alkyl-, wherein the Ci.&alkyl, C2-6alkenyl, C2-e alkynyl, C&-Karyl, Cs-Mcyeloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyi, Cs-ir ary l-Ci-6alkyl-, C3-14 cycloalkyl-Ci-e alkyl-, (5-14 membered heteroaryl)-Cj-6alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6alkyl- of R°2are each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R<Jsubstituents; each R is independently selected from H, OH, CN, C.-s alkyl, C.-s alkoxy, Ci-6haloalkyl, Cj-ehaloalkoxy, C2-6 alkenyl, C2-&alkynyl, Ca-u aryd, Ch-w eyeloalkyi, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyi, Ce-u aryl-C i-b alkyl-, C3-14 cycloalky 1- Ci-f,alkyl-, (5-14 membered heteroar l) -Cj-6alkyl-, and (4-14 membered heterocycloalkyl)-Cj-6alkyl-;each Rcand Rg2is independently selected from H, Ci-e alkyl, Cw, haloalkyl, Cj-6alkoxy, Ci^ aloalkyl, Cj-ehaloalkoxy, C2-6 alkenyl, C2-6alkynyl, CS-Maryd, Cs-wcycloalkyl, 5-14 membered heteroary l, 4-14 membered heterocycloalkyi, CM* aryl-C 1-6 alkyl-, C3 -14 eycloalkyd-C]-6alkyl-, (5-14 membered heteroaryd)-Ci-6alkyl-, and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-:each Rh2and Rl3is independently selected from H, Ci-s aikyi, Ci-6haloalkyl, C2-6 alkenyl, C2-6 alkynyl, Ce-w aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C6-i4 aryt-C -6alkyl-, Cs-w eyeloalkyi-Ci-e alkyl-, (5-14 membered heteroaiyl)-Ci.6 alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6 alkyl-;each Rj2and R*2is independently selected from OH, C -s alkoxy, and Ci-shaloalkoxy; or any Rj2and Rk2attached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from Ci-6alkyl and C 1-6 haloalkyl; each Rc, RE, RM, Rr, and R° is independently selected from D, halo, oxo, Ci-e alkyl, Ci-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C6- Haryl, C3-14 cyctoalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C&04 ary l-Ci-s alkyl-, Cs-ir cycloalkyi-Ci-e alkyl-, (5-14 membered heteroaryl) -Ci ..6alkyl-, (4-14 membered heterocycloalkyl)-Ci^, alkyl-, CN,0P(0)(0Rh4)(0Ri4), P(0)(0RM)(0Ri4), and BRJ+Rk4, wherein the Ci-6alkyl, C2-6 alkenyl, C2-6alkynyl, C&.14 aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 memberedheterocycloalkyl, Ce-i4 aryl-Cs-6alkyl-, Cs-w eyeloalkyi-Ci-e alkyl-, (5-14 membered heteroaryl)-Ci.6 alkyl-, and (4-14 membered heterocycloalkyl)-C½ alkyl- of Rc, Rb, RM, Rr, and Ruare each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected RHsubstituents;each Ra4, Rc4, and Rd4is independently selected from H, Ci-e alkyl, Ci-6haloalkyl, C2-6alkenyl, C2-6 alkynyl, Ce-w aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce- aryl-C 1.5 alkyl-, C3-14 cycloalky I-C1-6 alkyl-, (5-14 membered heteroaryl)-Ci-6alkyl-, and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-, wherein the Ci-6 alkyl, C2-6alkenyl, C2-6alkynyl, Ce-u aryi, Cs-u cycloalkyi, 5-14 membered heteroaiyd, 4-14 membered heterocycloalkyl, C -u aryl-Ci-e alkyl-, C3-Hcycloalky l-C -6alkyl-, (5-14 membered heteroaryl)-C 1-6 alkyl-, and (4-14 membered heteroeycloaikyi)-C i-6 alkyl- of Ra4, Rc4, and Rd4are each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected Rhsubstituents;or, any Rc4and Ra4attached to the same N atom, together with the N atom to which they are attached, optionally form a 5- or 6-membered heteroaryl or a 4-14 memberedheterocycloalkyl group, wherein the 5- or 6-membered heteroaryl or 4-14 memberedheterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected RHsubstituents;each Rb4is independently selected from H, C alkyl, CMhaloaikyl, C2-6 alken l, C2.6 alkynyl, Ca-u aryl, C3-i4 cycloalkyl, 5-14 membered heteroaryl, 4-14 memberedheterocycloalkyl, Ce-ir aryd-Ci-e alkyl-, Cs-u cycloalkyl-Ci-e alkyl-, (5-14 membered heteroaryd)-Ci-6alkyl-, and (4-14 membered heterocycloalkyl)-C alkyl-, wherein the CMalkyl, C2-6 alkenyl, C2-6 alkynyl, Ce-u aryl, C3-i4 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Cs-w ary 1-CMalkyl-, C3-14 cycloalky l-Ci-6 alkyl-, (5-14 membered heteroaryl)-C 1-6 alkyl-, and (4-14 membered heterocycloaikyi)-Ci-6 alkyl- of RD4are each optionally substituted with 1 , 2, 3, 4, 5, 6, 7, or 8 independently selected RHsubstituents; each R®4is independently selected from H, OH, CN, CM, alkyl, CM, alkoxy, C haloaikyl, Cj-ehaloalkoxy, C2-6 alkenyl, C2-6 alkynyl, Ce-u aryl, C3-i4 cycloalkyl, 5-14 membered heteroaiyl, 4-14 membered heterocycloalkyl, Ce-n ary l-Ci-6alkyl-, C3..14 cycloalky 1- C i-6alkyl-, (5-14 membered heteroaryl)-CMalkyl-, and (4-14 membered heterocycloalkyl)-Ci-6alkyl-;each Rf4and R*4is independently selected from H, CM, alkyl, CMalkoxy, Ci-6 haloaikyl, Ci-ehaloalkoxj', C2-6 alkenyl, C2-6 alkynyl, Ce- aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalky 1, Ce-i4 aryd-CMalkyl-, C3-14 cycloalky 1- Cs-6 alkyl-, (5-14 membered heteroaiyl) -C 1-5 alkyl-, and (4-14 membered heterocycloalkyl)-C]- 6 alkyl-;each R1*4and Rl4is independently selected from H, Ci-g alkyl. C , haloaikyl, C2-6 alkenyl, C2-6 alkynyl, Ce-u aryl, C3-14 cycloalkyl, 5-14 membered heteroaiyi, 4-14 membered heterocycloalkyl, Ce-w ary l-Ci-6 alkyl-, C3-14 cycloalkyl-Cw alkyl-, (5-14 membered heteroaryl)-Ci-6 alkyi-, and (4-14 membered heterocycioalkyi)-Cs-6 alkyl-;each R·'4and Rk4is independently selected from OH, Ci-ealkoxy, and Ci-ehaloalkoxy ; or, any Rj+and Rk4attached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from CMalkyl and CMhaloaikyl;each RHis independently selected from D, halo, oxo, CMalkyl, CMhaloaikyl, C2-6 alkenyl, C2-6 alkynyl, C&-14 aryl, C3..1+ cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-u aryd-C 1-6 alkyl-, C3-i4 cycloalkyl-Ci-6 alkyl-, (5-14 membered heteroaryl)-Ci-6alkyl-, (4-14 membered heterocycloalky 1)-CMalkyl-, CN, NO2, OR85, SR85, NHQRa5, C(0)Rb5, C(0)NRc5Rd5, C(0)NRc5(0Ra5), C(0)0Ra5, 0C(0)Rb5, 0C(0)NRc5Rd5,NRc?'Rd5, NRc5NRc5Rd5_ NRc5C(0)Rb5, N R'X iOlOR ". NRc5C(0)NRc5Rd5, C(=NRe5)Rb5,C (=NRe5)NRc5R<15, NRc5C(=NRc5)NRc5Rd5, NRc5C(=NRe5)Rb5, NRc5S(0)Rb\NR-'SiOsXR-'R1'. NRc5S(0)2Rb5, NRcSS(0)(=NReS)Rb5, NRc5S(0)2NRc5Rd5, S(0)Rb5, S(0)NRc5Rd5, S(0)2Rb5, S(0)2NRc5Rd5. 08(0c M K \ OSiO! -R1". SF5, PiOiR 'K". OPiOXOR^XOR15), P(0)(0R!LS)(0Ri5), and BRPR*5, wherein the CMalkyl, C2-6alkenyl, C2-6 alkynyl, 65-14 aryl, 63-14 cycloalkyl, 5-14 membered heteroaiyl, 4-14 memberedheterocycloalkyl, CMAary 1-Ci-e, alkyl-, C3-14 cycloalkyl-Ci-e alkyl-, (5-14 membered heteroaryl)-C]-6alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6alkyl- of Rhare each optionally substituted with 1, 2, 3, or 4 independently selected R1substituents;each Ra5, R°5, and Rdiis independently selected from H, C i-s alkyl, 61-5haloalkyl, C2-6 alkenyl, 62-5 alkynyl, 65-11 a d, 63-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C * aryl-6 -6 alkyl-, C3-14 cycloalkyl-Ci-e alkyl-, (5-14 membered heteroaryl)-6i-6 alkyl-, and (4-14 membered heterocycloalky 1)~6R>alkyl-, wherein the 61-6 alkyl 62-s alkenyl, 62 « alkynyl, 65-14aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, 65-114 aryl-61-6 alkyl-, 63-1 cycioalkyl-Oi-6 alkyl-, (5-14 membered heteroaryi)-Ci-5 alkyl-, and (4-14 membered heterocycloalkyi)-C 1.5 alkyl- of R35, Rcd, and Rdaare each optionally substituted with 1, 2, 3, or 4 independently selected R!substituents;or any R05and Rdaattached to the same N atom, together with the N atom to which they are attached, form a 5- or 6-membered heteroaryl or a 4-14 membered heterocycloalkyl group, wherein the 5- or 6-membered heteroaryl or 4-14 membered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected R!substituents;each Rtois independently selected from H, 61-5 alkyl, 62-6alkenyl, 62-f!alkynyl, Ce-w ary l, 63-14 cycloalkyl, 5-14 membered heteroaiyl, 4-14 membered heterocycloalkyl, 65-14 aryl- Ci-6 alkyl-, C3-14 eyeloalkyl-Ci-e alkyl-, (5-14 membered heteroaryl)-6i-5 alkyl-, and (4-14 membered heterocycloalkyl)-6i-6 alkyl- wherein the 1-5 alkyl, C2-&alkenyl, C2-6 alkynyl, Ce¬ltand, 63.14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloaikyl, 5-1 aryl-61-6 alkyl-, C3-14 cycloalkyl-6 ue alkyl-, (5-14 membered heteroar d)-Ci-6 alkyl-, and (4-14 membered heterocycloalky 1)-6I-6alkyl- of Rb5are each optionally substituted with 1, 2, 3, or 4 independently selected R1substituents;each Re5is independently selected from H, OH, 6N, 64-5 alkyl, Ci-ealkoxy, 61 -5 haloalkyl, 6i-6haioalkoxy, 62-5 alkenyl, 62-5 alkynyl, 65-14 aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloaikyl, 65-14 aryl-6 i-e alkyl-, 63-14 cycloalkyl- 61-5 alkyl-, (5-14 membered heteroaiyll-Oi-g alkyl-, and (4-14 membered heterocycloalkyl)-6i- 5 alkyl-;each Rf5and RS3is independently selected from H, Ci-e alkyl Ci-e alkoxy, Ci-e haloalkyl, C;i-f!haloa3koxy, C2-6 alkenyl, C2-6 alkynyl, Ce-w aiyl, C3-Hcycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl,€b- aryl-C -6alkyl-, Cs-i cydoalkyi- Ci-6alkyl-, (5-14 membered heteroaryl) -C1-6 alkyl-, and (4-14 membered heterocycloalky 1)-Ci.&alkyl-;each R115and R1'is independently selected from H, C -g alkyl, C -g haloalkyl, C2-6 alkenyl, C2-6 alkynyl, Cg-u aryl, C -u cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-w aryl-Ci-g alkyl-, C -i+ cycloalkyl-C -e alkyl-, (5-14 membered heteroaryl)-Ci-6alkyl-, and (4-14 membered heterocycloalky 1)-C 1.6 alkyl-;each RJiand R’° is independently selected from OH, C .g alkoxy, and C i-ghaloalkoxy; or, any Rj5and Rk?' attached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from Ci-e alky l and C -g haloalkyl;each R1is independently selected from D, halo, oxo, C .-g alkyl, C .-g haloalkyl, C2-6 alkenyl, C2-6 alkynyl, Ce-w aryl, Cj-w cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Cg-u aryl-C 1.5 alkyl-, C3-1 cycloalky I-C1-6 alkyl-, (5-14 membered heteroaryl)-Ci-6 alkyl-, and (4-14 membered heterocycloalkyl)-C [-6 alkyl-, CN, NO2, ORa6,0P(0)(0Rh6)(0Rl6), P(0)(0Rb6)(0R16), and BRJ6R“, wherein the C -6alkyl, C2-g alkenyl, C2-g alkynyl, Cg-u aryl,€3-14 cycloalky 1, 5-14 membered heteroaryl, 4-14 memberedheterocycloalkyl, Cg-u aryl-C i-g alkyl-, C3-i4cycloalkyl-C -6alkyl-, (5-14 membered heteroaryl)-Ci-6alkyl-, and (4-14 membered heterocycloalky l)-C 1.6 alkyl- of R1are each optionally substituted with 1, 2, 3, or 4 independently selected RJsubstituents;each R86, Rcf>, and Rd6is independently selected from H, Cj-b alkyl, Ci-e haloalkyl, C2-6 alkenyl,€2-6 alkynyl, Ce-w aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C6-i4 aryl-C -g alkyl-, C3-Mcycloalky l-C -6 alkyl-, (5-14 membered heteroaryl)-Ci.6alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6alkyl-, wherein the C .g alkyl, C2-6 alkenyl, C2-6 alkynyl, Cg-w aryl, Ci-Kcycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Cg-u aryl-C -6alkyl-, CS-Mcycloalky l-C -6alkyl-, (5-14 memberedheteroaryl)-C -6 alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6alkyl- of Ra6, Rc5, and Rd6are each optionally substituted with 1, 2, 3, or 4 independently selected R' substituents;or any Rc6and Rd6attached to the same N atom, together with the N atom to which they are attached, form a 5- or 6-membered heteroaryl or a 4-14 membered heterocycloalkyl group, wherein the 5- or 6-membered heteroaryl or 4-14 membered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected RJsubstituents;each Rb6is independently selected from H, Ci-e alkyl, Ci-e haloalkyl, C2-6 alkenyl, C2-6 alkynyl, Ce- aryd, C3-14cycloalkyl, 5-14 membered heteroaryl, 4-14 memberedheterocycloalkyl, Cg-w aryl-C1.5alkyl-, C3-14cycloalky l-Ci-g alkyl-, (5-14 membered heteroaryiVC i-g alky 1-, and (4-14 membered heterocyeloaikyi)-C[-s alkyl-, wherein the Ci-s alkyl, C2-6 alkenyl, C2-6 alkynyl, Ce-u aryd, C3-i4cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Cg-u aryl-Ci-g alkyl-, C3-Mcycloalk l-C -g alkyl-, (5-14 membered heteroaryl)-Ci-6alky 1-, and (4-14 membered heterocycloaikyi)~Ci-g alkyl- of RBbare each optionally substituted with 1, 2, 3, or 4 independently selected RJsubstituents;each R66is independently selected from H, OH, CN, Cj-g alkyl, Cfr-g alkoxy, Cw haloalkyl, Ci-ghaloalkoxy, C2-6 alkenyl, C2.6 alkynyl, Cg-ir aryl, C3-14cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C&-14ar l-Ci-6alkyl-, C3-14cycloalkyl- Ci-6alkyl-, (5-14 membered heteroaryl)-Ci-6alkyl-, and (4-14 membered heterocycloaikyl)~Ci-6alkyl-;each Rfband Rg5is independently selected from H, Cfr-g alkyl, Cs-g alkoxy, Ci-g haloalkyl, Ci-ghaloalkoxy, C2-6 alkenyl,€2-5 alkynyl, Cg-n aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalky 1, Cg-u and -Ci-g alkyl-, C3-14cycloallcyl- Ci-g alkyl-, (5-14 membered heteroaiyll-Ci- alkyl-, and (4-14 membered heterocycloalkyl)-C].g alkyl-;each Rhband R16is independently selected from H, Ci-g aikyd, Ci-g haloalkyl, C2-6 alkenyl, C2-6 alkynyl, Cg-j4aryd, C3-14cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-w ary I-C1-& alkyl-, C3-14cycloalkyl-Cw alkyl-, (5-14 membered heteroaryl)-C]-6alkyl-, and (4-14 membered heterocycioalkyl)-Ci-g alkyl-;each Rj5and Rteis independently selected from OH, Ci-galkoxy, and C -ghaloalkoxy ; or, any Rj6and Rk5attached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1 , 2, 3, or 4 substituents independently selected from Cb-g aikyd and Ci-g haloalkyl;each R3is independently selected from D, halo, oxo, C _g alkyl, C _g haloalkyl, Cb-g alkenyl, C?_-g alkynyl, Cg-u aryd, C3-14cycloalkyl, 5-14 membered heteroaryl, 4-14 memberedheterocycloalkyl, Ce-w ary l-Ci-6 alkyl-, Cj-i+ cycloalkyl-Cj-e alkyl-, (5-14 membered heteroaryl)-C]^ alkyl-, and (4-14 membered heterocycloa3kyl)-Ci-6 alkyl-, CN, NO2, ORa?, SRa7, NHORa7, C(0)Rb7, C(0)NRc7Rd7, C(0)NRc7(0Ra7), C(0)0Ra7, 0C(0)Rb7,0C(0)NRc7Rd7, NRc7Rd7, NRc7NRc7Rd7,NRe7C(0)Rb7, NRc7C(0)GRa7, NRc7C(G)NRc7Rd7, C(=NRe7)Rb7, C(=NRe7)NRc7Rd7, NRc7C(=NRe7VNRc7Rd7, NRc7C(=NRe7)Rb7, NRc7S(0)Rb7, NRc 7S(0)NRc?Rd?, NRc7S(0)2Rb7, NRc7S(0)(=NRe7)Rb7, NRc7S(0)2NRc7Rd7, S(0)Rb7, S(0)NRc7Rd7, SsOi -R1'. S(0)2NRc7Rd7, 0S(0)(=NRe7)Rb7, 0S(0)2Rb7, SF5, P(0)Rf¾g7, 0P(0)(0Rh7)(0Ri7), P(0)(0Rh7)(0Rl7), and BRi7Rk7, wherein the Ci-6alkyl C2-6 alkenyl C2-6alkynyl C&.14 aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl 4-14 memberedheterocycloalkyl, Ce-i4 aryl-Cj-6 alkyl-, Cs-u cycloalkyl-Ci-e alkyl-, (5-14 membered heteroaryl)-C]-6 alkyl-, and (4-14 membered heterocy cloalkyi)-Ci-6 alkyl- of RJare each optionally substituted with 1 , 2, 3, or 4 independently selected R substituents;each Ra / , Rc7, and Rd7is independently selected from H, Ci-6alkyl Ci-6haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C&-1 aryl, C3..14 cycloalky 1, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-u aryd-C i-e alkyl-, C3-i cycloalkyl-Ci-6 alkyl-, (5-14 membered heteroaryl)-Ci-6alkyl-, and (4-14 membered heterocycloalky 1)-C 1.6 alkyl- wherein the Ci-e alkyl, C2-6 alkenyl, C2-6 alkynyl Ce-w aryl, C3-14 cycloalky 1, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-u aryl-Ci-e alkyl-, C3-14 cycloalky l-Ci-6 alkyl-, (5-14 membered heteroaryl)-Ci-6alkyl-, and (4-14 membered heterocycloalky 1)-C 1.6 alkyl- of Ra / , Rc', and Rd' are each optionally substituted with 1, 2, 3, or 4 independently selected RKsubstituents; or any R0?and Rd / attached to the same N atom, together with the N atom to which they are attached, form a 5- or 6-membered heteroary l or a 4-14 membered heterocycloalkyl group, wherein the 5- or 6-membered heteroaryl or 4-14 membered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected RKsubstituents;each Rb7is independently selected from H, Cj-6alkyl, Cj-6haloalkyl C2-6 alkenyl, C2-6 alkynyl, C&-14 aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl 4-14 memberedheterocycloalkyl, Ce-w ary I-C1-& alkyl-, C3-14 cycloalkyl-Ci-e alkyl-, (5-14 membered heteroaryl)-C]-6 alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6 alkyl-, wherein the Cj-e alkyl, C2-&alkenyl, C2-&alkynyl, Ce-w aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C6-H aryl-Ci-e alkyl-, CVw cycloalkyl-C i-e alkyl-, (5-14 membered heteroaryl)-Ci-6 alkyl-, and (4-14 membered heterocycloalkyl)-C½alkyl- of Rb7are each optionally substituted with 1 , 2, 3, or 4 independently selected R substituents;each R8 / is independently selected from H, OH, CN, Ci-e alkyl, C2-6 alkenyl, Ci-e alkoxy, Ci-s haloalkyl, Ci-ehaloalkoxy, C2-6 alkynyl, C -n aryl, C3-34 cycloalkyl, 5-14 membered heteroaryl, and 4-14 membered heterocycloalkyl;each Rnand Rg / is independently selected from H, Ci-e alkyl, CMalkoxy, C haloalkyl, C -ghaloalkoxy, C2-6 alkenyl, C2-6 alkynyl, Ca-u aryl, C;-w eyeloalkyi, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Cg-i4aryl-Ci-g alkyl-, C3-14 cycloalkyl- CMalkyl-, (5-14 membered heteroaryl) -CMalkyl-, and (4-14 membered heterocycloalkyI)-C -6alkyl-;each Rh?and R" is independently selected from H, CMalkyl, C haloalkyl, C2-6 alkenyl, C2-6alkynyl, Cg-k aryl, C-t-u cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Cg-w ary 1-CMalkyl-, C -i+cycloalkyl-C -e alkyl-, (5-14 membered heteroaryl)-C ^ alkyl-, and (4-14 membered heterocycloalkyi)-Ci-6 alkyl-;each Rj7and Rk' is independently selected from OH, CMalkoxy, and Ci-ghaloalkoxy; or, any Rj' and Rk / attached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from CMalkyl and Ci-g haloalkyl;each RKis independently selected from H, D, OH, halo, oxo, CN, C(0)0H, NH2,NO2, SFs, C -g alkyl, C alkoxy, Ci-ghaloaikoxy, CM haloalkyl, Ch-g alkenyl, CC-g alkynyl, Cg. 1 and, C3.14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Cg-i4aryl-Ci-6alkyl-, CVw cycloalkyl-Ci-e alkyl-, (5-14 membered heteroard)-Ci-g alkyl-, and (4-14 membered heterocycloalky 1)-CMalkyl-; andwherein any heteroaryl group of any of the above-recited substituents optionally comprises an N-oxide on any ring-forming nitrogen.In some embodiments, the compound of Formula (I) is a compound of Formula (II):or a pharmaceutically acceptable salt thereof.In some embodiments, the compound of Formula (I) is a compound of Formula (III):or a pharmaceutically acceptable salt thereof.In some embodiments, Cy1is CS-M aryl, wherein the CM4 aryl is optionally substituted with 1, 2, 3, or 4 independently selected REsubstituents.In some embodiments, Cy1is C3-14 cycloalkyl, wherein the C3-14 cycloalkyl is optionally substituted with I, 2, 3, or 4 independently selected REsubstituents.In some embodiments, CyJis 5-14 membered heteroaryl, wherein the 5-14 membered heteroaryl is optionally substituted with 1 , 2, 3, or 4 independently selected REsubstituents.In some embodiments, C!is 4-14 membered heterocycloalkyl, wherein the 4-14 membered heterocycloalkyl is optionally substituted with 1, 2, 3, or 4 independently selected REsubstituents.In some embodiments, Cy1is C -10 aryl, wherein the Ce-io aryl is optionally substituted with 1, 2, 3, or 4 independently selected REsubstituents.In some embodiments, Cy1is C3..7 cycloalkyl, wherein the C3-7 cycloalkyl is optionally substituted with 1, 2, 3, or 4 independently selected REsubstituents.In some embodiments, C!is 5-10 membered heteroaryl, wherein the 5-10 membered heteroaryl is optionally substituted with 1, 2, 3, or 4 independently selected R:substituents.In some embodiments, Cy1is 4-10 membered heterocycloalkyl, wherein the 4-10 membered heterocycloalkyl is optionally substituted with 1, 2, 3, or 4 independently selected REsubstituents.In some embodiments, Cy1is phenyl or 5-10 membered heteroaryl, wherein the phenyl or 5-10 membered heteroaryl is optionally substituted with l, 2, 3, or 4 independently selected REsubstituents.In some embodiments, CyJis phenyl, optionally substituted with 1, 2, 3, or 4 independently selected RMsubstituents, or C7-14 aryl or 5-14 membered heteroaryl wherein the Cj-uaryl and 5-14 membered heteroaryl are optionally substituted with I, 2, 3, or 4 independently selected Rrsubstituents, andwberein each RMis independently selected from D, halo, oxo, C -6alkyl, C -6haloalkyl, Ci-e alkoxy, C2-6 alkenyl, C2-6 alkynyl, C4aryl, C3-14 cycloalkyl, 5-14 memberedheteroaryl, 4-14 membered heterocycloalkyi, 2-CN, 3-CN, N02, OR84, SRa4, NHORa4,NRc4S(0)Rb4, N R- 'SiOi Rb!. and NRc4S(0)2NRc4Rd4, wherein the Ci alkyl, Ci.5alkoxy , C2.salkenyl, C2-6alkynyl, Ce-uaiyl, C3-14cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyi of RMare each optionally substituted with 1, 2, 3, or 4 independently selected R'1substituents.In some embodiments, Cy1is selected from phenyl, pyridinyl, furanyl, benzofuranyl, and pyrazolyl, each of which is optionally substituted with 1, 2, or 3 substituents selected from C -3alkyl, halo, CN, and C1-3alkoxy.In some embodiments, the optionally substituted Cy1is selected from cyanophenyl, cyanofluorophenyl, 2, 3-dihydro- l f-pyrrolo[2, 3, -6]pyridine, phenyl, methoxyphenyl, fluorophenyl, pyridinyl, methylfuranyi, benzofuranyl, and methyl-l / Z-pyrazolyl.In some embodiments, the optionally substituted Cy!is selected from cyanophenyl, 2,3-dihydro-l / / -pyrrolo[2,3,-h]pyridine, phenyl, methoxyphenyl, fluorophenyl, pyridinyl, methylfuranyi, benzofuranyl, and methyl- l / / -pyrazolyl.In some embodiments, Cy1is selected from 2-cyanophenyl, 3 -cyanophenyl, 3-cyano-2 -fluorophenyl, 2,3-dihydro-I / / -pyrrolo[2,3,-djpyridine, phenyl, 3 -methoxyphenyl, 2- fluorophenyl, pyridine-4-yl, 2-methylfuran-3-yl, benzofuran-2-yl, and 1 -methyl- l / / -pyrazol- 4-yl.In some embodiments, the optionally substituted Cy1is selected from 2-cyanophenyl,3 -cyanophenyl, 2,3-dihydro- l / i-pyrro!o[2, 3, - ?]pyridine, phenyl, 3-methoxyphenyl, 2- fluorophenyl, pyridine-4-yl, 2-methylfuran-3-yl, benzofuran-2-yl, and 1 -meth l- 1 / 7-pyrazol-4-yl.In some embodiments, the optionally substituted Cy!is selected from 3-cyanophenyl and phenyl.In some embodiments, Cy1is 3-cyanophenyl.In some embodiments, Cy2is Cg-ir aryl, Cs-Mcycloalkyi, 5-14 membered heteroaryl or 4-14 membered heterocycloalkyi wherein the CV-r arcl, C4-14cycloalkyl, 5-14 membered heteroaryl and 4-14 membered heterocycloalkyi are optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected Rbsubstituents.In some embodiments, Cy2is CS-Haryl, wherein the Ce-n aryl is optionally substituted with 1, 2, 3, or 4 independently selected Rhsubstituents.In some embodiments, Cy2is C -u cycloalkyl, wherein the C3-14 cycloalkyl is optionally substituted with 1 , 2, 3, or 4 independently selected R"substituents.In some embodiments, Cy2is 5-14 membered heteroaryl, wherein the 5-14 membered heteroaiyl is optionally substituted with 1, 2, 3, or 4 independently selected Rrsubstituents.In some embodiments, Cy2is 4-14 membered heterocycloalkyl, wherein the 4-14 membered heterocycloalkyl is optionally substituted with 1, 2, 3, or 4 independently selected RFsubstituents.In some embodiments, Cy2is Cg-io aryl, wherein the Ce-io aryl is optionally substituted with I, 2, 3, or 4 independently selected RFsubstituents.In some embodiments, Cy2is C3-7 cycloaikyi, wherein the C3-7 cycloalkyl is optionally substituted with 1, 2, 3, or 4 independently selected Rfsubstituents.In some embodiments, Cy2is 5-10 membered heteroaryl, wherein the 5-10 membered heteroaryl is optionally substituted with 1, 2, 3, or 4 independently selected RFsubstituents.In some embodiments, Cy2is 4-10 membered heterocycloalkyl, wherein the 4-10 membered heterocycloalkyl is optionally substituted with 1, 2, 3, or 4 independently selected Rrsubstituents.In some embodiments, Cy2is selected from C cycloalkyl, phenyl, 5-10 membered heteroaryl, and 5-10 membered heterocycloalkyl;wherein the 5-10 membered heteroaiyl and 5-10 membered heterocycloalkyl each comprise one, two, or three nitrogen atoms as ring-forming heteroatoms, wherein one of the one or two nitrogen atoms is optionally an N-oxide, and wherein a ring-forming carbon atom is optionally substituted by oxo; andwherein the C3-6 cycloaikyi, phenyl, 5-10 membered heteroaryl, and 5-10 membered heterocycloalkyl are each optionally substituted with I, 2, or 3 substituents selected from C 1..3 alkyl, Ci alkyi-OH, halo, CM, CK;alkoxy, and C(0)NH2In some embodiments, Cy2is selected from C cycloaikyi, phenyl, 5-10 membered heteroaiyl, and 5-10 membered heterocycloalkyl;wherein the 5-10 membered heteroaryl and 5-10 membered heterocycloalkyl each comprise one or two nitrogen atoms as ring-forming heteroatoms, where in one of the one or two nitrogen atoms is optionally an N-oxide, and wirerein a ring-forming carbon atom is optionally substituted by oxo; and-wherein the C cycloaikyi, Ce-aryi, 5-10 membered heteroaiyl, and 5-10 membered heterocycloalkyl are each optionally substituted with 1, 2, or 3 substituents selected from C 1-3 alkyl, halo, CN, C 1-3 alkoxy, and C(0)NH>; .In some embodiments, Cy2is selected from pyridinyl, tetrahydropyridinyl, piperidinyl, pvridine-N-oxide, oxo-dihydropyridinyl, phenyl, pyrazolo[l,5-a]pyridin-3-yl, pyrazolo[l,5-b]pyridazinyl, pyrazolyl, pyrimidinyl, quinolinyl, oxazolyl, 2,3-dihydro- [l,4]dioxino[2,3-b]pyridin-8-yl, and triazolyl each of which is optionally substituted with I,2, or 3 substituents selected from C1-3 alkyl, Ci-3 alkyl-OH, halo, CN, Ci-3 alkoxy, and ( (O)N I SIn some embodiments, Cy2is selected from pyridinyl, tetrah dropyridinyl, piperidinyl, pyridine-N-oxide, oxo-dihydropyridinyl, phenyl, pyrazolo[l,5-a]pyridin-3-yl, pyrazolo[l,5-b]pyridazinyl, pyrazolyl, pyrimidinyl, quinolinyl, oxazolyl, and 2,3-dihydro- [l,4]dioxino[2,3-b]pyridin-8-yl, each of which is optionally substituted with 1, 2, or 3 substituents selected from Ci-3alkyl, halo, CN, Ci-3alkoxy, and C(0)NH2.In some embodiments, Cy2is selected from pyridinyl, tetrahydropyridinyl, piperidinyl, pyridine-N-oxide, oxo-dihydropyridinyl, phenyl, pyrazolo| l,5-a]pyridin-3-yl, pyrazolyl, pyrimidinyl, and 2,3-dihydro-[l,4]dioxino[2,3-b]pyridin-8-yl, each of which is optionally substituted with 1 , 2, or 3 substituents selected from Ci-3 alkyl, halo, CN, C1-3 alkoxy, and C(0)NH2.In some embodiments, Cy2is cyclopropyl optionally substituted with 1, 2, or 3 substituents selected from Cu alkyl, halo, CN, C1-3 alkoxy, and C(0)NH2.In some embodiments, the optionally substituted Cy2is selected from 2,6- dimethy!pyridin-4-yl, pyridin-4-yl, 2-methylpyridin-4-yl, 1 -carbamoy 1-1, 2,3,6- tetrahydropyridin-4-yl, 1 -carbamoy lpiperidin-4-yl, 2-methoxypyridin-4-yl, 2-methoxy-6- methylpyridin-4-yl, 2,6-dimethylpyridin-4-yl-l-oxide, l-ethyl-6-oxo- l,6-dihydropyridin-3-yl, 3-methyipyridin-4~yi, 3-fluoropyridin~4-yl, 3-chloropyridin-4-yl, 3-methoxypyridin-4-yl, 3- cyanopyridin-4-yl, 4-carbamoylphenyl, pyrazolo[l,5-a]pyridin-3-yl, pyrazolo[l,5- bJpyridazin-3-yl, 5 -methyl- lH-pyrazol-4-yl, l-etbyl-lH-pyrazol-5-yl, 1 -isopropyl- 1H- pyrazol-5 -y 1, 1 -propyl- 1 H-py razol-5 -y 1, py rirnidin-4-y 1, 2,3 -dihy dro- [1,4] dioxino [2,3 - b]py ridin-8-yl, quinolin-5-yl, 5-fluoropyrimidin-4-yl, oxazol-5-yl, 4-methyloxazol-5-yl, 4- ethyloxazol-5-yl, 4-(liydroxymethyl)-2-methyloxazol-5-yl, 4-(methoxymethyl)~2- methy loxazol-5 -y 1, 4-(hy droxymethy l)-2-methy loxazol-5-y 1, 1 -ethyl- 1 H- 1 ,2,3 -triazol-5 -y 1, and cyclopropylIn some embodiments, the optionally substituted Cy2is selected from 2,6- dimethylpyridin-4-yl, pyridin-4-yl, 2-methylpyridin-4-yl, 1 -carbamoy 1-1 , 2,3,6- tetrahydropyridin-4-yl, 1 -carbamoy lpiperidin-4-yl, 2-methoxypyridin-4-yl, 2-methoxy -6- methylpyridin-4-yl, 2,6-dimethylpyridin-4-yl-l -oxide, l-ethyl-6-oxo-l,6-dihydropyridin-3-yl,3-methylpyridin-4-yl, 3-f]uoropyridin-4-yl, 3-chloropyridin-4-yl, 3-methoxypyridin-4-yl, 3- cyanopyridin-4-yl, 4-carbamoylphenyl, pyrazolo[ l,5-£i]pyridin-3-yl, pyrazolo[l,5- b]pyridazin-3-yl, 5-methyl-l H-pyrazol-4-yl, l-ethyl-lH-pyrazol-5-yl, 1 -isopropyl -1H- pyrazol-5-yl, 1 -propyl- lH-pyrazol-5 -y 1, p rimidin-4-y 1, 2,3 -dihydro- [ 1 ,4]dioxino [2,3 - bjpyridin-8-yl, quinolm-5-yl, 5-fluoropyrimidin-4-yl, 4-methyloxazoi-5-yl, 4- (hy droxymethy l)-2-methy ioxazoi-5 -y 1, 4-(methoxymethy 3)-2-methy loxazoi-5 -y 1, and cyclopropyl.In some embodiments, the optionally substituted Cy2is selected from 2,6- dimethy lpyridin-4-y 1, p ridin-4-y 1, 2-methylpyridin-4-y 1, 1 -carbamoyl- 1, 2,3,6- tetrahydropyridin-4-yl, l-carbamoylpiperidin-4-yl, 2-methoxypyridin-4-yl, 2,6- dimethy lpyridin-4-y 1- 1 -oxide, 1 -ethy 1-6-oxo- 1 ,6-dihydropyridin-3 -y 1, 3 -methy lpyridin-4-y 1, 3-fluoropyriditi-4-yl, 3-chloropyriditi-4-yl, 3-methoxypyridin-4-yl, 3-cyanopyridin-4-yl, 4- carbamoy lpheny 1, pyrazolo [ 1 ,5 -a jpy ridin-3 -y 1, 5 -methyl- 1 H-pyrazol-4-y 1, 1 -ethy 1- 1 H- pyrazol-5-yl, l-isopropyl-lH-pyrazol-5-yl, l-propyl-lH-pyrazol-5-yl, pyrimidin-4-yl, 2,3- dihydro-[l,4]dioxino[2,3-b]pyridin-8-yl, and cyclopropyl.In some embodiments, R!is selected from H, D, Ci-b alkyl, Ci-6haloalkyl, C2.6alkenyl, C2-6alkynyl, Cf.- r aryl, C3-14cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-w aryl-Ci-e alkyl-, Cs-u cycloalkyl-Ci-e alkyl-, (5-14 membered heteroaryl)-Ci-6 alkyl-, (4-14 membered heterocycloalky l)-Ci-6 alkyl-, ORai, C(0)Rb!, C(0)NRclRdl, C(0)0RaI, C(=NRel)Rbl, C(=NRel)NRclRdl, S(0)Rbl, S(0)NRc!Rd!, S(0)2Rb!and S(0)2NRclRdl, wherein the C2-6alkenyl,€2-5alkynyl, Ce-ir aryl, C3-14cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, CM 4ar I-C1-&alkyl-,€3-14cycloalkyl- Ci-6alkyl-, (5-14 membered heteroaiydt-Ci-g alkyl-, and (4-14 membered heterocycloalkyl)-C].dalkyl- of R1are each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected RBsubstituents.In some embodiments, R!is selected from H, D, Ci-b alkyl, Cue haloalkyl, C2-6alkenyl, C2-6alkynyl, Cf.- + aryl, C3-14cycloalkyl, 5-8 membered heteroaryl, 4- 14 membered heterocycloalkyl, Ce-w aiyd-Ci-e alkyl-, Cs-u cycloalkyl-Ci-e alkyl-, (5-8 membered heteroaryl)- C -6 alkyl-, (4-14 membered heterocycioalkyl)-Ci-6 lkyl-, ORai, C(0)Rb l, C(0)NRc!Rai, C(0)0Rai, C(=NRel)Rbl, C(=NReI)NRclRdl, S(0)Rbl, S(0)NRciRdi. S(0)2RbiandS(0)2NRciRdi, wherein the C2-6 alkenyl, C2-6alkynyl, Cs-ir atyl, C3-14cycloalkyl, 5-8 membered heteroaryl, 4-14 membered heterocycloalkyl, CM4aryl-Ci^ alkyl-, C3-14cycloalkyl- Ci-6alkyl-, (5-8 membered heteroary'l)-C -6alky 3-, and (4-14 membered heterocycloalky l)-Ci-6alkyl- of R1are each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected RBsubstituents.In some embodiments, R1is selected from H, Ch-s alkyl, and 5-8 membered heteroaryl, wherein the 5-8 membered heteroaryl is optionally subsituted by 1 or 2 independently selected KBsubstituents.In some embodiments, R!is H, Cj-e alkyl, or a 5-8 membered heteroarylIn some embodiments,1is H or Ci-e alkyl.In some embodiments, R!is H or C 1-3 alkyl.In some embodiments, R!is H, ethyl, or nicotinonitrile.In some embodiments, R1is H or ethyl.In some embodiments, R1is H.In some embodiments, R!is 5-8 membered heteroary l which is optionally subsituted by 1 or 2 independently selected RBsubstituents.In some embodiments, R1is 5-8 membered heteroaryl.In some embodiments, R1is pyridyl which is optionally substituted by 1 or 2 RBsubstituents.In some embodiments, R1is pyridyl which is optionally substituted by cyano.In some embodiments, R1is nicotinonitrile.In some embodiments, R!is 3-cyanopyridyl.In some embodiments, R2is selected from halo, Cs-6alkyl, Cj-5 haloalkyl, C2-0 alkenyl, C2-6 alkynyl, C&-14 aryl, C3..14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalky 1, CM* aiyl-C w, alkyl-, C3-14 cycloalkyl-Cj-e alkyl-, (5- 14 membered heteroaryl)-Ci-6 alkyl-, (4-14 membered heterocycloalk l)-Ci-6 alkyl-, CN, NO2, OR32, SR82,0P(0)(0Rh2)(0R’2), P(0)(0Rh2)(0Rl2), and BR R' '. wherein the C1-6alkyl, C2-6alkenyl, C2-6alkynyl, CM* aryl, Cs-sr cycloalkyi, 5-14 membered heteroaryl, 4-14 memberedheterocycloalkyl, Ce-w ary l-Ci-6 alkyl-, C3-14 cycloalkyl-Cw alkyl-, (5-14 membered heteroaryl)-C]-6 alkyl-, and (4-14 membered heterocycIoalkyl)-C]-6 alkyl- are each optionally substituted with I, 2, 3, 4, 5, 6, 7, or 8 independently selected Rcsubstituents; andwherein the C -e alkyl is substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected Rcsubstituents.In some embodiments, R2is selected from Cs-6alkyl, CM4 aryl, C?,-u cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-i4 ary l-Ci-6 alkyl-, C3..14 cycloalky 1- C i-6 alkyl-, (5-14 membered heteroary l)-Ci-s alkyl-, (4-14 membered heterocycloalkyl)-Ci-6 alkyl-, C(0)Rb2, C(0)NRe2Rd2, C(0)0Ra2, and NRc2Rd2, wherein the CM4aryl, C3-i4cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Cw4 aryl-Ci-6alkyl-, C3-14 cycloalky 1-C alkyl-, (5-14 membered heteroaryl)-Ci-6 alkyl-, and (4-14 membered heterocycloalkyi)-Ci-6alkyl- are each optionally substituted with 1, 2, 3, 4, or 5 independently selected Rcsubstituents; and-wherein the C -e alkyl is substituted with 1, 2, 3, 4, or 5 independently selected RLsubstituents.In some embodiments, R2is selected from CS-Maryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C 4 aryl-Ci-6 alkyl-, C3-14 cycloalky 1-Cw alkyl-, (5-14 membered heteroaryl) -Cs-6alkyl-, (4-14 membered heterocycloalkyl)-C]-6alkyl-, C(0)Rb3, C(0)NRc2Rd2, C(0)QRa2, and \ R- R!. wherein the C6.i4 aryl, C3.14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C ary l-Ci-6 alkyl-, C3.14 cycloalkyl- Ci-6alkyl-, (5-14 membered heteroary l)-Ci-6alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6alkyl- are each optionally substituted with 1, 2, 3, 4, or 5 independently selected Rcsubstituents.In some embodiments, R2is selected from Ce-u and, C3-i4cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloaikyl, C6-Maryl-Ci-6alkyl-, C3-Wcycloalky 1-C 1-6 alkyl-, (5-14 membered heteroary 1)-C 1-6 alkyl-, and (4-14 membered heterocycloalkyll-Ci-e alkyl-, wherein the Ce-u aryl, C3-14 cycloalkyl, 5-14 membered heteroaiyl, 4-14 membered heterocycloaikyl, Ce-u aryl-C 1-6 alkyl-, C3-i4cycloalkyl-C -6alkyl-, (5-14 membered heteroary l)-Ci-6alkyl-, and (4-14 membered heterocycloalky 1)-C 1.6 alkyl- are each optionally substituted with 1, 2, 3, 4, or 5 independently selectedsubstituents.In some embodiments, R2is selected from H, Ci-e alky l, C3-14 cycloalkyl, C 4aryl, 5- 14 membered heteroary!, 4-14 membered heterocycloalky 1, CHaryl-Ci-6alkyl-, C3-14 cycloalky 1-C 1-6 alkyl-, (5-14 membered heteroary l)-C]-6alkyl-, (4-14 memberedheterocycloalkyl)-Ci-6alkyi-, NRc2Rd2, C(0)RB2, C(0)NRc2Rd2, and C(0)0Ra2, wherein the Cj.6alkyl, C3-i4 cycloalkyl, C6-i4 aryl, 5-14 membered heteroaryl, 4-14 memberedheterocycloaikyl, C6-i4 aiyd-Ci-6alkyl-, Cs-u cycloalkyl-Ci-e alkyl-, (5-14 memberedheteroaryl)-C]-6 alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6 alkyl- are each optionally substituted with 1 , 2, or 3 independently selected Rcsubstituents.In some embodiments, R2is selected from H, Ci-e alkyl, Ce-Maryi, C3-14cycloalkyl, 5- 14 membered heteroaryl, 4-14 membered heterocycloalkyl, CG-Maiyl-Ci-e alkyl-, CS-Mcycloalkyl-Ci-6 alkyl-, (5-14 membered heteroaryl)-Ci-6 alkyl-, (4-14 memberedheterocycloalkyi)-C i-6alkyl-, OR32, NRc2Rd2, C(0)Rb2, C(0)NRc2Rd2, and C(0)0Ra2, wherein the C -6alkyl, CG-Maryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-Mary 1-CI-G alkyl-, C -i+ cycloalkyl-C -e alkyl-, (5-14 membered heteroary l)-Ci-6 alkyl-, and (4-14 membered heterocycloalky l)-Ci-6 alkyl-, are each optionally substituted with 1, 2, or 3 independently selected Rcsubstituents.In some embodiments, R2is selected from H, C --6alky l, Ce-Maryl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C6-Maryl-Ci-6alky!-, (5-14 membered heteroary l)-Ci-6alkyl-, (4-14 membered heterocycloalky l)-Ci-6alkyl-, NRc2Rd2, C(0)Rb2, C(0)NRc2Ra2, and C(G)ORa2, wherein the Ci-e alkyl, Ce-n aryl, 5-14 membered heieroaryd, 4- 14 membered heterocycloalkyl, CG-Maryl -CI-Galkyl-, (5-14 membered heteroaryl)-Ci-6alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6alkyl- are each optionally substituted with 1, 2, or 3 independently selectedsubstituents.In some embodiments, R2is selected from H, C - -6 alky l, Ce-Maryl,€3-54 cycloalkyl, 5- 14 membered heteroaryl, 4-14 membered heterocycloalkyl,aryl-C 1-6 alkyl-, C3.14 cycloalkyl-Ci-Galkyl-, (5-14 membered heteroary l)-C]-6alkyl-, (4-14 memberedheterocy cloalky 1)-C 1 -s alley 1-, ORa2, NRc2Rd2, C(0)Rb2, C(0)NRc2Rd2, and C(0)0Ra2, wherein the Ci -6 alkyl, CG-Maryl, C3 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, CG-I4aiyl-Ci-e alkyl-, Cs-u cycloalkyi-Ci-G alkyl-, (5-14 membered heteroatyl)-Ci-6 alkyl-, and (4-14 membered heterocy cloalky 1)-CI.G alkyl-, are each substituted with 1 , 2, or 3 independently selected RLsubstituentsIn some embodiments, R2is selected from H, CJ..Galkyl, CG-Maryl, C3-14 cycloalkyl, 5- 14 membered heteroaryl, 4-14 membered heterocycloalkyl, CG-Maryl-C -6alkyl-, C3-M cycloalkyl-Ci-6alkyl-, (5-14 membered heteroary l)-Ci-6alkyl-, (4-14 memberedheterocycloalkyl)-Ci-6alkyl-, NRciRd2, C(0)R02, C(0)NRc2Rd2, and C(0)0Rai, wherein the Ci-6alkyd, Cs-ir aryd, CS-Mcycloalkyl, 5-14 membered heteroary !, 4-14 memberedheterocycloalkyl, Ce- ary 1-CI-G alkyl-, C3- cycloalkyl-Cw alkyl-, (5-14 membered heteroary l)-C]-6alkyl-, and (4-14 membered heterocycioalkyi)-Cs-6alkyl- are each substituted with 1, 2, or 3 independently selected R'-substituents.In some embodiments, R' is selected from H, Ce-uaryl, 5-14 membered heteroaryl, C(0)Rb2, C(0)NRc2R®, and C(0)0Ra2, wherein the Co-u aryl and 5-14 membered heteroaryl are each optionally substituted wdth 1, 2, or 3 independently selected Rcsubstituents.In some embodiments, R;is selected from H, C.-s alkyl, phenyl, 5-6 membered heteroaryl, 4-10 membered heterocydoalkyi, Ce-io aryl-Ci-s alkyl-, (5-10 membered heteroaryl)-Ci-6alkyl-, (4-10 membered heterocycloalk I)-Cw alkyl-, NRc2Rd2, C(0)Rb2, C(0)NRc2Ra2, and C(0)ORa2, wherein the C -6alkyl, phenyl, 5-6 membered heteroaryl, 4-10 membered heterocydoalkyi, Ce-io aryl-C -e alkyl-, (5-10 membered heteroaryl)-Ci-6alkyl-, and (4-10 membered heterocycloalkyl)-Ci..6alkyl- are each optionally substituted with 1 or 2 independently selected Rcsubstituents. In some embodiments, R2is selected from H, phenyl, 5-6 membered heteroaryl, C(0)Rb / , C(0)NRc2Ra2, and C(Q)ORa2, wherein the phenyl and 5-6 membered heteroaryl are each optionally substituted with 1 or 2 independently selected Rcsubstituents.In some embodiments, R;is selected from H, C(0)OEt, CONH2, and C(0)NHEt.In some embodiments, R2selected from phenyl and 5-6 membered heteroaryl, each of which is optionally substituted with C(0)OMe.In some embodiments, the optionally substituted R is selected from pyridinyhnethyl, hydroxy(phenyl)meth I, hydroxyethylamino(phenyl)ethyi, cyclohexyhnethyl, fluorobenzyl, hydroxy (fluoropheny Ijmethy 1, (me thy lpy ridiny Ijmethy L (fluoropy ridiny l)methy 1,(ti itluoromethylpyridinyl)methyl, ((hydrox}rmethyi)pyridinyl)methyi,(methoxypy ridiny l)me thy 1, (methylpyrazolyl)benzyl, (melhylpyrazolyl)methyl,benzoisoxazolylmethyl, (methylindazolyl)methyl, (hydro xyazetidinyl)methyl, benzoyl, phenylcyclopropyi, (cyano(phenyl)meihyl)amino, tetxahydrofiuanyl,pheny l(py ridiny loxy)methy 1, Iluoro ((lluorohy droxypyrrolidiny l)methy l)benzy 1,((earboxypiperidinyl)methyl)fluorobenzyi, fluoro((N- methylmeihylstdfonamido)methyl)benzyl, ((dioxoimidazolidinyl)methyl)fluorobenzyl, (difluorophenyl)(hydroxy)methyl, (pyridinyl-lH-tetrazolyl)methyL (pyrazolyl- lH- tetrazolyl)methyl, (thiazolyl-lH-tetrazolyl)methyl, (methyltrifluoromethylpyrazolyl)methyl, ((Ll-dioxidoisothiazolidinyl)meihyl)iluorobenzyl, ((methyl-2, 5- dioxoimidazolidinyl)methyl)benzyl, and (cyanophenoxy)methyl.In some embodiments, the optionally substituted Rzis selected from pyridinyhnethyl, hydroxy (pheny l)methyl, hydroxy ethylamino(phenyl)ethyl, cyclohexyhnethyl, fluorobenzyl, hydroxy (fluoropheny l)m ethyl, (methylpyridinyi)methyl, (fluoropyridinyl)methyi,(methoxypyridinyl)methyl, (methylpyrazolyl)benzyl, benzoisoxazolylmethyl,(methylindazolyl)methyl, (hydroxyazetidinyi)methyl, benzoyl, phenylcyclopropyl,(cyano(phenyl)methyl)amino, tetrahydrofurasiyl, phenyl(pyridinyloxy)methyl, fluoro ((fluorohydroxypyrrolidinyl)metliyl)benzyl, ((carboxypiperidmyl)methyl)fluorobenzjd, fluoro((N -me thy ime thy lsulfonamido)methy l)benzy 1,((dioxoimidazolidmyl)methyl)fluorobenzyl, and (difluorophenyl)(hydroxy)methyl.In some embodiments, R2is selected from pyridinyimethyl, hydroxy(phenyi)methyl, hydroxy ethylami:no(phe:nyl)ethyl, eyclohexyimethyl, fluorobenzyl,hydroxy (fluorophenyl)methyi, (methylpyridinyl)methyi, (fluoropyridinyl)methyl,(meihoxypyridinyl)methyl, (meth lpyrazolyl)benzyl, benzoisoxazoly ime thyi,(methyiindazolyi)methyl, (hydroxyazetidinyl)methyl, benzoyl, phenylcyclopropyl,(cyano(phenyl)methyl)amino, tetrahydrofuranyl, and phenyl(pyridinyloxy)methyl.In some embodiments,In some embodiments, R2is selected from pyridin-2-ylmethyl,hydroxy (phenyl)methyl, (2-hydroxyethylammo)(phenyl)methyl, eyclohexyimethyl, 2- fluorobenzy 1, (2-fluorophenyl)(hy droxy)methy 1, (6-methy lpyridin-2-yl)methyl, (3 - fluoropyridin-2-yl)methyl, (3-methoxypyridin-2-yl)methyl, 2-(l -methyl- lH-pyrazol-4- yllbenzyl, benzo[d]isoxazol-3-ylmethyl, (l-methyl-lH-indazol-3-yl)methyi, (3- hydroxyazetidin-l-y!)m ethyl, benzoyl, 1 -phenylcyclopropyl, (cyano(phenyl)methyl)amino, tetrahydrofuran-3-yl, phenyl(pyridm-2-yloxy)methyl, 2-fluoro-6-(((3R,4R)-3-fluoro-4- hydroxy py rrolidin- 1 -yl)me thy l)benzy 1, 2-((4-carboxypiperidin- 1 -y l)methy l)-6-lluorobenzyi, 2-fluoro-6-((N-methylmethylsulfonamido)methyl)benzyl, 2-((2,5-dioxoimidazolidin-l- yI)methyl)-6-fiuorobenzyl, (2,6-difluorophenyl)(hydroxy)methyl, (5-(pyridin-2-yl)-lH- tetrazol- 3 -y l)methy 1, (5 -(1 H-pyrazol- 3 -y l)-l H-tetrazol- 1 -yl)me thyi, (5 -(thiazol-4-y 1)- 1 H- tetrazol-l-yl)methyl, (5-methyl-3-(trifluoromethyl)-lH-pyrazol-l -yl)methyl (3- methy lpy ridin-2-y l)methy 1, 2-(( 1 , 1 -dioxidoiso thiazolidin-2-y i)methy 1) -6-fluorobenzy 1, 2- fluoro-6-((3-methyl-2,5-dioxoimidazolidm-l-yl)methyl)benzyl, (6-(trifluoromethyl)pyridin-2- yltmethyl, (3-(hydroxymethyl)pyridin-2-yl)methyl, (l-methyl-lH-pyrazol-3-yl)methyi, and (2-cyanophenoxy)methyl,(3-methylpyridiii-2-yl)methoxy, (6-methy lpyridin-2-yl)methoxy, and ((3-methyipyridm-2-yi)methyl)ammo.In some embodiments, R2is selected from pyridin-2-ylmethyl,hydroxy (phenyl)metliyl, (2-hydroxyethylamino)(phenyl)methyl, eyclohexyimethyl, 2- fluorobenzyl, (2-fluoropheny i)(hy droxy)methy 1, (6-methy lpyridin-2-yl)methy 1, (3 -fluoropyridin-2-yl)methyl, (3-methoxypyridin-2-yl)methyl, 2-(l-methyl-lH-pyrazol-4- yl)benzyl, benzo[d]isoxazol-3-ylmethyl, (l-methyl-lH-indazol-3-yl)methyl, (3- hydroxyazetidin-l-yl)methyl, benzoyl, 1-phenylcyclopropyl, (eyano(phenyi)methyl)amino, tetrahydrofuran-3-yl, phenyi(pyridin-2-yloxy)methyl, 2-fluoro-6-(((3R,4R)-3-fluoro-4- hydroxypyrrolidin-l-yl)methyl)benzyl, 2-((4-carboxypiperidin-1 -yl)methyl)-6-fluorobenzyl, 2-fluoro-6-((N-methylmeihylsulfonamido)methyl)beiizyl, 2-((2,5-dioxoimidazolidin-l- yl)methyl)-6-fluorobenzyl, and (2,6-difluorophenyl)(hydroxy)methyl.In some embodiments, R2is selected from pyridin-2-ylmethyl,hydroxy (phenyl)inethyl, 2-hydroxy ethylamino)(phenyl)methyl, cyclohexylmethyl, 2- fluorobenzyl, 2-fluorophenyl)(hydroxy)methyl, 6-methylpyridin-2-yl)methyl, 3- fluoropyridin-2-yl)methyl, 3-methoxypyridin-2-yl)methyl, 2-(l-methyl-IH-pyrazol-4- ylibenzyl, benzo[d]isoxazol-3-ylmethyl, l-meihyl-lH-mdazol-3-yi)methyl, 3- hydroxyazetidin-l~yi)methyl, benzoyl, 1-phenylcyclopropyl, (cyano(phenyl)methyl)amino, tetrahydrofuran-3-y 1, and phenyl(py ridin-2-y ioxy)methy 1.In some embodiments, R32is selected from H and Ci-s alkyl, wherein the C -5 alkyl is optionally substituted 1, 2, or 3 independently selected R11substituents.In some embodiments, Rb2is selected from H, Ci-6alkyl, Ce-w asyl, and 4- 14 membered heterocycloalkyl, wherein the C -e alkyl, Ce-u ary l, and 4-14 membered heterocycloalkyl are each optionally substituted with 1, 2, or 3 independently selected R° substituents.In some embodiments, Rc2and Rd2are each independently selected from H, Ci-b alkyl, 5-14 membered heteroaryl, and Ce-u ary l-C -6alkyl-, wherein the C -e alkyl, 5- 14 membered heteroaryl, and Ce-u ary l-Ci-6alkyl- are each optionally substituted with 1, 2, or 3 independently selected R° substituents.In some embodiments, each R° is indepedently selected from CN, ORa4, and Ci-s alkyl, wherein the Ci-6alkyl is optionally substituted I, 2, or 3 independently selected Rflsubstituents.In some embodiments, each Rcis independently selected from halo, Ci-b alkyl, Ce-u aryl, 5-14 membered heteroaryd, (4-14 membered keterocycloalkyl)-Ci-6alkyl-, OR34, C(0)0Ra+, and NRc4Rd4, wherein the Ci-6alkyl, 5-14 membered heteroaryl, and (4-14 membered heterocycloalkyl)-Ci-6 alkyl- are optionally substituted with I, 2, or 3independently selected RHsubstituents.In some embodiments, each R'-is independently selected from halo, Ci-e alkyl, C6-i4 aryl, 5-14 membered heteroaryl, (4-14 membered heterocycloalkyl)-Ci-6alkyl-, OR34,C(0)0Ra4, and NRc4Rd4, wherein the CMalkyl, 5-14 membered heteroaryl, and (4-14 membered heterocycloalky3)-Ci-6alkyl- are substituted with 1, 2, or 3 independently selected Rrisubstituents.In some embodiments, R*4is selected from H, CMalkyl, Ce-w aryl, and 5-14 membered heteroaryi.In some embodiments, each Rc4and Rd4are independently selected from H and CMalkyl, wherein the CM, alkyl is optionally substituted by I , 2, or 3 independently selected R'1substituents.In some embodiments, each R'1is independently selected from halo, oxo, CMalkyl, Cs-6 haloalkyi, OR85, C(0)GRa5, and NRc5S(0)2Rb5.In some embodiments, each Ra', and Rc5is selected from H and CMalkyl.In some embodiments, Rtois selected from H and CMalkyl.In some embodiments, R3is selected from H, D, halo, oxo, CMalkyl, CMhaloalkyi, C2-6 alkenyl, C2-6 alkynyl, C&.14 aryl, C3-14 cycloalkyl, 5-14 membered heteroaryi, 4-14 membered heterocycloalkyl, Cs-w ar i-C alkyl-, CVw cycloalkyl-CMalkyl-, (5-14 membered heteroaryl)-Ci-6 alkyl-, (4-14 membered heterocycloalky l)-Ci-6 alkyl-, CN, NO2, GRaJ, SR83,P(0)(0RB)(0Rs3), B(OR“)2and S(0)2NRc3Rd3, wherein the CMalkyl, CMalkenyl, C2.6alkynyl, Ce-n aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 memberedheterocycloalkyl, Ce-i4 aryd-CMalkyl-, C3-1 cycloalky 1-C alkyl-, (5-14 membered heteroaryl)-Ci-6 alkyl-, and (4-14 membered heterocycloalky 1)-CMalkyl- of R3are each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R!)substituents.In some embodiments, R is selected from H, halo, CMalkyl, CMhaloalkyi, C&-J4 aryl, 5-14 membered heteroaryi, CN, and GRa;i, wherein the CMalkyl, Ce-uaryl, and 5-14 membered heteroaryi are each optionally substituted with 1, 2, or 3 independently selectedsubstituents.In some embodiments, R’ is selected from H, CMalkyl, halo, CN, morpholinomethyl, 4-ethoxyphenyi, 2-hydroxyethoxy, and pyridinyl.In some embodiments, RJis selected from H, methyl, bromo, CN, morpholinomethyl, 4- ethoxyphenyl, 2 -hydroxy ethoxy, and pyridinyl.In some embodiments, X is CR3; and R!is H or Cj-e alkyl.In some embodiments, X is CR3; and R!is H or Ci-3alkyl.In some embodiments,X is CR3;R1is selected from H and Ci-e alkyl;R2is selected from H, D, Ce-u aiyl, 5-14 membered heteroaryi, C(0)Rb2,C(0)NRc2Rd2, and C(0)QRa2, wherein the Ce-u ryl and 5-14 membered heteroaryl of R2are each optionally substituted with 1, 2, 3, or 4 independently selected RLsubstituents;R3is selected from H, D, halo, Ci-b alkyl, Ci-b haloalkyl, Ce-u aryl, 5-14 membered heteroaryl, CN, and ORa3, wherein the Ci-6alkyl, Ce-n aryl, and 5-14 membered heteroaryl of R5are each optionally substituted with 1, 2, 3, or 4 independently selected R° substituents;Cy1is phenyl optionally substituted with 1 , 2, 3, or 4 independently selected RMsubstituents, or Cio-i4 aryl or 5-14 membered heteroaryi, wherein the Cio-u aryl and 5-14 membered heteroaryi of Cy1is optionally substituted with I, 2, 3, or 4 independently selected REsubstituents;Cy2is C&.14 aryl, C3-14 cycloalkyl, 5-14 membered heteroaryi or 4-14 membered heterocycloalkyl, wherein the Cg-w aryl, Cso 4 cycloalkyl, 5- 14 membered heteroaryi and 4-14 membered heterocycloalkyl of Cy2are each optionally substituted with 1, 2, 3, or 4 independently selected R" substituents;each R32, Rc2, Rd2, and Ra3is independently selected from H, Ci-6alkyl, C1 -6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C&.i4aryl, C3-14 cycloalkyl, 5-14 membered heteroaryi, and 4-14 membered heterocycloalkyl, wherein the Cj-6alkyl, C2-6 alkenyl, C2-6 alkynyl, Cg-w aryl, C3-14 cycloalky l, 5-14 membered heteroaryi, and 4-14 membered heterocycloalkyl of Ra2, Rc2, Rd2, and Ra3are each optionally substituted with 1, 2, 3, or 4 independently selected R° substituents;each Rb2is independently selected from Ci-6alkyl, Ci-6haloalkyl, C2-6 alkenyl, C2-6 alkynyl, Ci.-n aryl, C3-14 cycloalkyl, 5-14 membered heteroaryi, and 4-14 membered heterocycloalkyl, wherein the Cj-e alkyl, C2-6 alkenyl, C2-6 alkynyl, Gs-rr aryl, Cs-n cycloaikyd, 5-14 membered heteroaryi, and 4-14 membered heterocycloalkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R° substituents;each Rc, R[), RE, R", and RGis independently selected from D, halo, oxo, Ci-6alk l, C i-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, Ce-w aryl, C3-i4cycloalkyl, 5-14 membered heteroaryi, 4-14 membered heterocycloaikyi, CN, NO2, OR34, SR®4, NHORa4, C(0)Rb4, C(0)NRc4Rd4, C(0)ORa4, OC(0)Rb4, 0C(0)NRc4Rd4, \ R!R; !. NRc4C(0)Rfc4, NRc4C(0)0Ra4,NRc+C(0)NRc4Rd4, C(=NRe4)Rb4, C(=NRe4)NRo4Rd45NRc4C(=NRe4)NRc4Rd+, NRe4S(0)RM, NRc4S(0)2Rb4, and NRc4S(0)2NRc4Rd4, wherein the Ci-6alkyl, C2-6alkenyl, C2-6alkynyl, CHaryl, C3-Mcycloalkyl, 5-14 membered heteroaryl, and 4-14 membered heterocycloalkyl of Rc, R4', Re, R4, and R° are each optionally substituted with 1, 2, 3, or 4 independently selected Rrisubstituents;each RMIS independently selected from D, halo, oxo, Ci-6alkyl, Cm haloalkyl, C2-6 alkenyl, C2-6alkynyl, Cf.-j+ aryl, C3-14cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, 2-CN, 3-CN, NO2, ORa4, SRa4, NHORa4, C(0)Rb4, C(0)NRc4Rd4, C(0)ORa4, OC(0)Rm, OC(G)NRc4Rd4, NRc4Rd4, NRc4C(0)Rb4, NRc4C(0)0Ra4, NRc4C(0)NRc4Rd4, C(=NRe4)RM, C(=NRe4)NRc4Rd4, NRc4C(=NRe4)NRc4Rd4, NRc4S(0)RM, NRc4S(0)2Rb4, and NRc4S(0)2NRc4Rd4, wherein the Cm alkyl, C2-6 alkenyl, C2-0alkynyl, Ce-Karyl, C3-14cycloalkyl, 5-14 membered heteroaryl, and 4-14 membered heterocycloalkyl of RMare each optionally substituted with 1, 2, 3, or 4 independently selected RHsubstituents;each Ra4, Rc4, and Rd4is independently selected from H, Ci-6alkyl, Ci-6haloalkyl, C2-6 alkenyl, C2-6 alkynyl, CVw aryl, C-t-u cycloalkyl, 5-14 membered heteroaryl, and 4-14 membered heterocycloalkyl, wherein the Cm alkyl, C2-6 alkenyl, C2-6 alkynyl, Cs-w aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, and 4-14 membered heterocycloalkyl of Ra4, Rc4, and Rd4are each optionally substituted with 1, 2, 3, or 4 independently selected RHsubstituents; each Rb4is independently selected from Ci-6alkyl, Ci-6haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C&-14 aryl,€3-14 cycloalkyl, 5-14 membered heteroaryl, and 4-14 membered heterocycloalkyl, wherein the Ci-e alkyl, C2-6 alkenyl, C2-6 alkynyl, Ce-ir aryl, Cs-r+ cycloalkyl, 5-14 membered heteroaryl, and 4-14 membered heterocycloalkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R1 !substituents;each Re4is independently selected from H, OH, CN, C .-s alkyl, C .-s alkoxy, Ci-6haloalkyl, and C i-shaloalkoxyyeach RHis independently selected from D, halo, oxo, Ci-6alkyl, Ci-b haloalk l, C2-6 alkenyl, C2-6 alkynyl, C&-J4 aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, CN, N02,OC(0)Rb5, 0C(0)NRc5Rd5,C(=NRe5)Rb5, C(=NRe5)NRcNRc5S(G)2NRc5Rd5, wherein the Ci-6 alkyl, C2.6 alkenyl, C2.6 alkynyl, Ce-i4 aryl, C3-14 cycloalkyl, 5-14 membered heteroaryd, 4-14 membered heterocycloalkyl, of RHare each optionally substituted with 1, 2, 3, or 4 independently selected R1substituents;each R3'5, Rc5, and Rd>is independently selected from H, Cj-b alkyl, Ci-e haloalkyl, C2-6 alkenyl, C2-6 alkynyl, Ce-w aryl, C -u cycloalkyl, 5-14 membered heteroaryl, and 4-14 membered heterocycloalkyl, wherein the C i-s alkyl, C2-6 alkenyl, C2-6 alkynyl, Cs-w ary!, C3-w cycloalkyl, 5-14 membered heteroaryl, and 4-14 membered heterocycloalkyl of Ra4, Rc4, and Rd4are each optionally substituted with 1, 2, 3, or 4 independently selected R!substituents; each Rb5is independently selected from Ci-e alkyl, Ci-e haloalkyl, C2-6 alkenyl, C2-6 alkynyl, Ci.-w aryl, C3-i cycloalkyl, 5-14 membered heteroaryl, and 4-14 membered heterocycloalkyl, -wherein the C -e alkyl, C2-6alkenyl, C2-6 alkynyl, C b-u aryl, C3-w cycloalkyl, 5-14 membered heteroaryl, and 4-14 membered heterocycloalkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R1substituents;each R85is independently selected from H, OH, CN, Ci-e alkyl, Ci-e alkoxy, Ci-e haloalkyl, and Ci-ehaloalkoxy;each R1is independently selected from D, halo, oxo, Ci-e alkyl, Cue haloalkyl, C2-6 alkenyl, C2-6 alkynyl, 0&-Maryl, C3..14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, CN, N02, OR36, SR*6, NHOR*6, C(0)Rbf>, C(0)NRc6Rd6, C(0)0Raf>, OC(0)Rb6, 0C(0)NRc6Rd6, NRc6Rd6, NRc6C(0)Rb6, NRc6C(0)0Ra6, NRc6C(G)NRc6Rd6, C(=NRe6)Rb6, C(=NRe6)NRc6Rd6, NRc6C(=NRe6)NRc6Rd6, NRc6S(0)Rb6, NRc6S(0)3Rb6, and NRc6S(0)2NRc6Rd6, wherein the Ci-6 alkyl, C2-6 alkenyl,€2-6 alkynyl, C&-u aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalky 1, of Rhare each optionally substituted with 1, 2, 3, or 4 independently selected RJsubstituents;each R36, Rcf>, and Rd6is independently selected from H, Ci-6alkyl, Ci-6haloalkyl, C2-6 alkenyl,€2-6 alkynyl, Ce-w aryl, CJ-Mcycloalkyl, 5-14 membered heteroaryl, and 4-14 membered heterocycloalkyl, wherein the CM alkyl, C2-6 alkenyl, C2-6 alkynyl, Ce-w aryl, C3-w cycloalkyl, 5-14 membered heteroaryl, and 4-14 membered heterocycloalkyl of Ra6, RCR, and Rd6are each optionally substituted with 1, 2, 3, or 4 independently selected RJsubstituents; each Rb6is independently selected from Ci« alkyl, Ci« haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C&-J4 aryl, C3-icycloalkyl, 5-14 membered heteroaryl, and 4-14 membered heterocycloalkyl, wdierein the C -e alkyl, C2-6 alkenyl, C2-6 alkynyl, C b-u aryl, C3-w cycloalkyl, 5-14 membered heteroaryl, and 4-14 membered heterocycloalkyl are each optionally substituted with 1, 2, 3, or 4 independently selected RJsubstituents;each Re6is independently selected from H, OH, CN, C .-s alkyl, C .-s alkoxy, Ci-6haloalkyl, and C i-ehaloalkoxy;each R3is independently selected from D, halo, oxo, C -e alkyl, C -e haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C w aryl, C3- cycloalkyl, 5-14 membered heteroaryl, 4-14 memberedheterocycloalkyl, CN, N02, OR37, SR37, NHORa?, C(0)Rb7, C(0)NRc7Rd7, C(0)ORa7,NRC / S(0)2NRC / Rd / , wherein the Ci-6 alkyl, C2.6 alkenyl, C2.6 alkynyi,€5-14 aryl, C3-14 cycloalkyl, 5-14 membered heteroaryd, 4-14 membered heterocycloalkyl, of RHare each optionally substituted with 1, 2, 3, or 4 independently selected RKsubstituents;each Ra / , Re', and Rd' is independently selected from H, Ci-6alkyl, Ci-6haloalkyl, C2-6 alkenyl, C2-6 alkynyi, Ce-i+aiyl, C3-14 cycloalkyl, 5-14 membered heteroaryd, and 4-14 membered heterocycloalkyl, wherein the Ci.&alkyl, C2-6 alkenyl, C2-6 alkynyi, Cs-waryl, C3-14 cycloalkyl, 5-14 membered heteroaiyi, and 4-14 membered heterocycloalkyl of Ra / , Rc7, and Rd' are each optionally substituted with 1, 2, 3, or 4 independently selected RKsubstituents; each Rb' is independently selected from Ci-e alkyl, Ci-e haloalkyl, C2-6 alkenyl, C2-6 alkynyi, Ce-u aryl, fb-ir cycloalkyl, 5-14 membered heteroaiyi, and 4-14 membered heterocycloalkyl, wherein the Ci-e alkyl, C2-6 alkenyl, C2-6 alkynyi, Gs-14 aryl, C3-14cycloalkyl, 5-14 membered heteroary l, and 4-14 membered heterocycloalkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R substituents;each Re7is independently selected from H, OH, CN, Ci-e alkyl, Ci-e alkoxy, Ci-&haloalkyl, and Ci-shaloalkoxy;each RKis independently selected from H, D, OH, halo, oxo, CN, C(0)0H, NH2, NO2, SF5, CI-6alkyl, Ci-e alkoxy, C -ehaloalkoxy, C *-6haloalkyl, tb-s alkenyl, C2-6alkynyi, C&.14 aryl, C3-14 cycloalkyl, 5-14 membered heteroaiyi, 4-14 membered heterocycloalkyl; and wherein any heteroaryl group of any of the above-recited substituents optionally comprises an N-oxide on any ring-forming nitrogen.In some embodiments,X is CR3;R!is selected from H and Ci-6alkyl;R2is selected from H, D, Cf,-i4 ryl, 5-14 membered heteroaryl, C(0)Rbi,C(0)NRc2Ra2, and C(0)ORa2, wherein the Ce-uaxyl and 5-14 membered heteroaryd of R2are each optionally substituted with 1, 2, 3, or 4 independently selected Rcsubstituents;R3is selected from H, D, halo, C -&alkyl, Ce-u aryl, 5-14 membered heteroaryd, CN, and OR33, wherein the Ci-e alkyl, Ce-w ar l, and 5-14 membered heteroaryd of R3are each optionally substituted with 1 , 2, 3, or 4 independently selected RDsubstituents;Cy1is pheny l, optionally substituted with 1, 2, 3, or 4 independently selected RMsubstituents; or Cy1is Cio-u and or 5-14 membered heteroaryd, wherein the CIO-Hand and 5-14 membered heteroaryl of Cy1are each optionally substituted with 1, 2, 3, or 4independently selected Rfcsubstituents;Cyzis Ce-u aryl, CB-Mcycloalkyl, 5-14 membered heteroaryl or 4-14 membered heterocycloalkyl, wherein the Ce-u aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl and 4-14 membered heterocycloalkyl of Cy2are each optionally substituted with 1, 2, 3, or 4 independently selected R' substituents;each R32, R“, Rdi, and Ra3is independently selected from H, Ci-6alkyl, C2-6 alkenyl, C2-6 alkynyl, Ce-n aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, and 4-14 membered heterocycloalkyl, wherein the CMalkyl, C2-6 alkenyl, C2-6 alkynyl, Ce-war l, C3-14 cycloalkyl, 5-14 membered heteroaryl, and 4-14 membered heterocycloalkyl of R32, Rc2, Rd2, and R33are each optionally substituted with 1, 2, 3, or 4 independently selected R substituents;each Rb2is independently selected from C alkyl, C2-6 alkenyl, C2-6 alkynyl, CM·» ary l, C3-!4 cycloalkyl, 5-14 membered heteroaryl, and 4-14 membered heterocycloalkyl, wherein the Ci-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C&.14 aryd, C3.14cycloalkyl, 5-14 membered heteroaryl, and 4-14 membered heterocycloalkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R° substituents;each Rc, RD, RE, Rr, and R° is independently selected from D, halo, oxo, CMalkyl, C2-6 alkenyl CMalkynyl, Ce-u aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, CN, N02, OR3, SR34, NHOR34, C(0)Rb4, C(Q)NRc4Rd4,NRc4S(0)2.Rb4, and NRc4S(0)2NRc4Rd4, wherein the Cw, alkyl, C2-6 alkenyl, C2-6 alkynyl, CMary l, C3-!4 cycloalkyl, 5-14 membered heteroaryl, and 4-14 membered heterocycloalkyl of Rc, R4', Re, R4, and R° are each optionally substituted with 1, 2, 3, or 4 independently selected Rrisubstituents;each RMis independently selected from D, halo, oxo, Ci-6alk l, C2.6 alkenyl, C2-6 alkynyl, Cw4ai l, C3-Wcycloalkyl, 5-14 membered heteroaryl, 4-14 memberedheterocycloalkyl, 2-CN, 3-CN, N02, OR34, SR34, NHOR34, C(0)Rb4, C(0)NRc4Rd4, C(0)0R34,NRc4S(0)2NRc4Rd4, wherein the Ci-6alkyl, C2-6 alkenyl, C2-6 alkynyl,€5-14 aryi, C3..14 cycloalkyl, 5-14 membered heteroaryl, and 4-14 membered heterocycloalkyl of RMare each optionally substituted with 1, 2, 3, or 4 independently selected RHsubstituents;each Ra+, Rc4, and Rd4is independently selected from H, Ci-e alkyl, C2-6 alkenyl, C2-6 alkynyl, Ce-i+aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, and 4-14 membered heterocycloalkyl, wherein the Ci-b alkyl, C2-6 alkenyl, C2-6 alkynyl, Ce-n aryl, Cs-w cycloalky 1, 5-14 membered heteroaryl, and 4-14 membered heterocycloalkyl of Ra4, Rc4, and Rd4are each optionally substituted with 1 , 2, 3, or 4 independently selected RHsubstituents;each RMis independently selected from C 1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl,aryl, C3-! 4 cycloalkyl, 5-14 membered heteroaryl, and 4-14 membered heterocycloalkyl, wherein the C -e alky l, C2-6 alkenyl, C2-6 alky nyl, Ce-u aryl,€3-5+cycloalkyl, 5-14 membered heteroaryl, and 4-14 membered heterocycloalk l are each optionally substituted with 1, 2, 3, or 4 independently selected RHsubstituents;each Rs+is independently selected from H, OH, CN, C--6alky l, C -e alkoxy, C1-6 haloalkyl, and Ci-ehaloalkoxy;each RHis independently selected from D, halo, oxo, Ci-e alkyl, CN, NO2, OR®5, SR33,each Ra5, R®3, and Rdsis independently selected from H, and Ci-b alkyl;each Rb3is independently selected from Ci-e alkyl, C2-e alkeny l, C2-6 alkynyl, Ce-n aryl, C3 -14 cycloalkyl, 5-14 membered heteroaryd, and 4-14 membered heterocycloalkyl; and each Re5is independently selected from H and C -6alkyl.In some embodiments,X is CR3;R!is selected from H and C -e alky l;R2is selected from H, D, Ce-io aryl, 5-10 membered heteroaryl, C(G)Rb2,C(0)NRc2Ra2, and C(0)ORa2, wherein the Ce-ioaryl and 5-10 membered heteroaryl of R2are each optionally substituted with 1, 2, 3, or 4 independently selected Rcsubstituents;R3is selected from H, D, halo, C -6alkyl, Cwo aiyl, 5-10 membered heteroaryl, CN, and OR83, wherein the Ci-b alkyl, Ce-ic. aryl, and 5-10 membered heteroaryl of R3are each optionally substituted with 1 , 2, 3, or 4 independently selected4' substituents;Cy!is pheny l, optionally substituted with 1 , 2, 3, or 4 independently selected RMsubstituents; or Cy1is C10 aryl, 4-10 membered heterocycloalkyl, or 5-10 membered heteroaryl, wherein the C10 aryl, 4-10 membered heterocycloalkyl, and 5-10 membered heteroaryl of Cy3are each optionally substituted with 1, 2, 3, or 4 independently selected R substituents;Cy2is Cb-io aiyl, C3-7 cycloalkyl, 5-10 membered heteroaryl or 4-10 membered heterocycloalkyl, wherein the Cb-io aryl, C3-7 cycloalkyl, 5-10 membered heteroaryl and 4-10 membered heteroeyeloalkyl of Cy2are each optionally substituted with 1, 2, 3, or 4 independently selected Rrsubstituents;each R32, Rci, Rd2, and R33is independently selected from H, Ci-s alkyl, C2-s alkenyl, C2-6 alkynyl, Ce-io ary l, C3-7 cycloalkyl, 5-10 membered heteroaryi, and 4-10 membered heteroeyeloalkyl, wherein the C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, Ce-io aryl, C3-7 cycloalkyl, 5-10 membered heteroaryl, and 4-10 membered heteroeyeloalkyl of Ra2, Rc2, Rd2, and R3Jare each optionally substituted with 1, 2, 3, or 4 independently selected RGsubstituents;each Rb2is independently selected from Cw alkyl, C2-6 alkenyl, C2-6 alkynyl, CS-JOaryl,€3-7 cycloalkyl, 5-10 membered heteroaryl, and 4-10 membered heteroeyeloalkyl, wherein the C , alkyl, C2-6 alkenyl, C2-6 alkynyl, Ce-io aryl, C3-7 cycloalkyl, 5-10 membered heteroaryi, and 4-10 membered heteroeyeloalkyl are each optionally substituted with 1 , 2, 3, or 4 independently selected R° substituents;each Rc, RD, RE, R" , and RGis independently selected from D, halo, oxo, Cw alkyl, €2-5 alkenyl, C2-Salkynyl, Cb-io aryl, C3-7 cycloalkyl, 5-10 membered heteroaryi, 4-10 membered heteroeyeloalkyl, CN, N02, OR!, i. SR34, NHORa4, C(0)Rb4, C(0)NRc4Rd4,NRC4S(0)2Rm, and NRc4S(0)2NRc4Rd4, wherein the Cj-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, Gs-so aryl, C3.7 cycloalkyl, 5-10 membered heteroaryi, and 4-10 membered heteroeyeloalkyl of R(\ Rd, Re, Rr, and RGare each optionally substituted with 1, 2, 3, or 4 independently selected RHsubstituents;each RMis independently selected from D, halo, oxo, Ci-s alkyl,€2-5 alkenyl, C2-Salkynyl, Ce-io aryl, C3-7 cycloaikyl, 5-10 membered heteroaryi, 4-10 memberedheteroeyeloalkyl, 2-CN, 3-CN. NO2, OR34, SRa4, M i OR'1. C(0)Rb4, C(0)NRc4Rd4, C(G)ORa4, OC(0)Rb4, OC (0)NRc4Rd4, NRc4Rd4, NRc4C(0)Rb4, NRc4C(0)0Ra4, NRc4C(0) Rc4Rd4, C(=NRe4)Rw, C(=NRe4)NRc4Rd4, NRc4C(=NRe4)NRo4Rd4, NRc4S(0)Rb4, NRc4S(0)2RM, and NRe4S(0)2NRc4Rd4, wherein the Ci-b alkyl, C2-f, alkenyl, C2-6 alkynyl, C6-]o ryl, C3-7 cycloalkyl, 5-10 membered heteroaryi, and 4-10 membered heteroeyeloalkyl of RMare each optionally substituted with 1, 2, 3, or 4 independently selected Rrisubstituents;each R34, Rc4, and Rd4is independently selected from H, CMalkyl, C2-6 alkenyl, C2-6 alkynyl, Ce-ioatyi, C3-7cycloalkyl, 5-10 membered heteroaiyl, and 4-10 membered heteroeyeloalkyl, wherein the CMalkyl, C2-6alkenyl, C2-6alkynyl, Ce- aryl, CVCyclQalky!,5-10 membered heteroaiyl, and 4-10 membered heterocycloalkyl of Ra4, Rc4, and Rd+are each optionally substituted with 1 , 2, 3, or 4 independently selected RMsubstituents;each Rfc+is independently selected from Cw alkyl, C2-e alkenyl, C2-6 alkynyl, CS-JOaryl, C3.7 cycloalkyl, 5-10 membered heteroaryl, and 4-10 membered heterocycloalkyl, wherein the Cj-6alkyl, C2-6 alkenyl, C2-6 alkynyl, Cs-io aryl, C3-7 cycloalkyl, 5-10 membered heteroaiyl, and 4-10 membered heterocycloalkyl are each optionally substituted with 1, 2, 3, or 4 independently selected Rrisubstituents;each R84is independently selected from H, OH, CN, Ci-e alky l, Ci-e alkoxy, Ci-e haloalkyl, and Ci-ehaloalkoxy;each RHis independently selected from D, halo, oxo, C -6alkyl, CN, NO2, OR35, SRa', NHOR35, C(0)Rb5, C(0)NRc5Rd5, C(0)ORa5, OC(0)Rb5, 0C(0)NRc5Rd5, NRc5Rd5,NRc5C(0)Rb5, NRc5C(0)0Ra5, NRc5C(0)NRc5Rd5, C(=NRe5)Rbs, C(=NRe5)NRc5Rd5,NRc5C(=NRe5)NRc5Rd5, NRc5S(0)Rb5, NRc5S(0)2Rb5, and NRc5S(0)2NRc5Rd5; andeach Ra\ Rcy and Rdsis independently selected from H, and Ci-b alkyl;each Rtois independently selected from Cs-6alkyl, C2-&alkenyl, C2-6 alkynyl, C 10 aryl, C3 -10 cycloalkyl, 5-10 membered heteroaryl, and 4-10 membered heterocycloalkyl; and each Re5is independently selected from H and C -6alkyl.In some embodiments,X is N;R1is selected from H, C -6alkyl, and a 5-14 membered heteroaryl, wherein the Ci-e alkyl and a 5-14 membered heteroaryl are each optionally substituted with 1, 2, or 3 independently selected RBsubstituents;R2is selected from H, D, Ci-6alkyl, Ce-uaryl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Cs-ir ary l-Ci-e alkyl-, (5-14 membered heteroaryi)-Ci-6 alkyl-, ( - 14 membered heterocycloalkyl)-C]< alkyl-, NR^R^.CCOiR02, C(0)NRc2Rd2, and C(0)ORa2, wherein the Ci-e alkyl, Ce- aryl, 5-14 membered heteroaryl, 4-14 memberedheterocycloalkyl, CMar I-C1-&alkyl-, (5-14 membered heteroar l) -C -6 alkyl-, (4-14 membered heterocycloalkyi)-Ci-6alkyl- of R2are each optionally substituted with 1, 2, 3, or 4 independently selected Rcsubstituents;Cy!is pheny l, optionally substituted with 1, 2, 3, or 4 independently selected RMsubstituents, or Cio-u aryl or 5-14 membered heteroaryl, wherein the CIO-Maryl and 5-14 membered heteroaryi of Cy!is optionally substituted with 1, 2, 3, or 4 independently selected R substituents;Cy2is Ce-i+ aiyl, C3-14 cycloalkyl, 5-14 membered heteroaryi or 4-14 membered heterocycloalkyl, wherein the CVi aiyi, C3-14 cycloalkyl, 5-14 membered heteroaryl and 4-14 membered heterocycloalkyl of Cy2are each optionally substituted with 1, 2, 3, or 4 independently selected Rrsubstituents;each R32, Rci, and Rd2is independently selected from H, C 1-5 alkyl, C2-6 alkenyl, C2-6 alkynyl, Ce-n aryl, Ce-ir aryl-C -.e alkyl-, CS-Mcycloalkyl, 5-14 membered heteroaryi, and 4-14 membered heterocy cloalkyl, wherein the Ci-6alkyl, C2-6 alkenyl, C2-6 alkynyl, Ce-i+aiyl, CMaryl-Ci-6 alkyl-, C3-Mcycloalkyl, 5-14 membered heteroaryi, and 4-14 memberedheterocycloalkyl of R32, Rci, and R02are each optionally substituted with 1, 2, 3, or 4 independently selected R° substituents;each Rb2is independently selected from C1-6 alkyl, C2-6 alkeny l, C2-6 alkynyl, Ce-n aryl, C3-14 cycloalkyl, 5-14 membered heteroaryi, and 4-14 membered heterocycloalkyl, wherein the Ci-e alkyl, C2-6 alkenyl, C2-6alkynyl, CS-Maryl, C3-14 cycloalkyl, 5-14 membered heteroaryi, and 4-14 membered heterocycloalkyl are each optionally substituted with 1, 2, 3, or 4 independently selected Rusubstituents;each Rb, Rc, R , Rb, and RGis independently selected from D, halo, oxo, C1.6 alkyl, C2-6 alkenyl, C2-6alkynyl, Ce-w aryl, C3-14 cycloalkyl, 5-14 membered heteroaryi, 4-14 membered heterocycloalkyl, CN, N02, OR34, SR®4, NHOR®4, C(0)RM, C(0)NRc4Rd4,NRC+S(0)2Rm, and NRo4S(0)2NRc4Rd4, wherein the Cwalley 1, C2.6alkenyl, C2.6alkynyl, Ce-u aryl, C3-14 cycloalkyl, 5-14 membered heteroaryi, and 4-14 membered heterocycloalkyl of RB, Rl, Rk, Rr, and R° are each optionally substituted with 1, 2, 3, or 4 independently selected RHsubstituents;each RMis independently selected from D, halo, oxo, Cs-6alkyl, C2-6alkenyl, C2-6 alkynyl, Ck-i+ aryl, C3-14 cycloalky 1, 5-14 membered heteroaryi, 4-14 memberedheterocycloalkyl, 2-CN, 3-CN, NO2, OR34, SR34, NHOR34, C(0)Rb4, C(0)NRc4Rd4, C(0)0R34,NRcS(0)2NRcRd4, wherein the Cs-6alkyl, C2-6 alkenyl, C2-6alkynyl, CVw axyl, C3-Mcycloalkyl, 5-14 membered heteroaryi, and 4-14 membered heterocycloalky 1 of RMare each optionally substituted with 1 , 2, 3, or 4 independently selected RHsubstituents;each R34, Rc+, and Rd4is independently selected from H, Ci-6alkyl, C2-6alkenyl, C2-6 alkynyl, Cf,- 4 aiyl, C3-i4cycioalkyl, 5-14 membered heteroaryd, and 4-14 memberedheterocycloalkyl, wherein the Ci-e alkyl, C2-6 alkenyl, C2-6 alkynyl, Ce-waxyl,€3-14 cycloalkyl, 5-14 membered heteroaryl, and 4-14 membered heterocycloalkyl of R34, R64, and Rd4are each optionally substituted with 1, 2, 3, or 4 independently selected RHsubstituents;each RMis independently selected from Ci« alkyl, C2« alkenyl, C2-6 alkynyl, Ce-14 a d, Cs- 14 cycloalkyl 5-14 membered heteroaryl, and 4-14 membered heterocycloalkyl, wherein the C -6 alkyl, C2-6 alkenyl, C2-6 alkynyl, CS-Maryl, Cs- cycloalkyl, 5-14 membered heteroaryl, and 4-14 membered heterocycloalkyl are each optionally substituted with 1 , 2, 3, or 4 independently selected Rrisubstituents;each Re4is independently selected from H, OH, CN, Cue alkyl, Ci-e alkoxy , Ci-e haloalkyl, and Ci-ehaloalkoxy;each RMis independently selected from D, halo, oxo, Cue alkyl, CN, NO2, ORa>, SR35, NHORa5, C(0)Rb5, C(0)NRc5Rd5, C(0)ORa5, OC(0)Rb5, 0C(0)NRc¾d5, NRc5Rd5,NRc5C(0)Rb5, NRc5C(0)0Ra5, NRc5C(0)NRc5Rd5, C(=NRe5)Rb5, C(=NRe5)NRc5Rd5,NRc5C(=NRe5)NRc5Rd5, NRc5S(0)Rbs, NRc5S(0)2Rb5, and NRc5S(0)2NRc5Rd5; andeach R3, Rc5, and Rd5is independently selected from H, and Cs-6alkyl;each Rb5is independently selected from Ci-6alkyl, C2-6 alkenyl, C2-6 alkynyl, CS-Maryl, C3-! 4 cycloalky 1, 5-14 membered heteroaryl, and 4-14 membered heterocycloalkyl; and each Re5is independently selected from H and Ci-6alkyl.In some embodiments,X is N;R1is H or a 5-14 membered heteroaryl optionally substituted with 1, 2, or 3 independently selected RBsubstituents;R2is selected Ci-6alkyl, 4-14 membered heterocycloalkyl, Cfr.34 ary I-C1-6 alkyl-, (5-14 membered heteroaryl)-Ci-6 alkyl-, (4-14 membered heterocycloalkyl)-C 1-5 alkyl-, and NRc2Rd2, wherein the C -6alkyl, 4-14 membered heterocycloalkyl, Ce-ir aryd-C i-b alkyl-, (5-14 membered heteroaryl)-Ci-6 alkyl-, and (4-14 membered heterocycloalkyl)-Ci..6 alkyl- of R2are each optionally substituted with 1, 2, or 3 independently selected Rcsubstituents;Cy!is phenyl optionally substituted with 1, 2, or 3 independently selected R' substituents; andCy2is 5-14 membered heteroaryl optionally substituted with 1 , 2, or 3 independently selected Rrsubstituents.in some embodiments,X is N;R!IS H or a 5-14 membered heteroaryl optionally substituted with 1, 2, or 3 independently selected RHsubstituents;each RBis independently selected from D, halo, oxo, C -6alkyl, C -6haloalkyi, C2-6 alkenyl, CN, NO2 and OH;R2is selected C i-s alkyl, 4-14 membered heterocycloalkyl, Ce-u ary l-Ci-6alkyl-, (5-14 membered heteroaryl)-Ci^ alkyl-, (4-14 membered heterocycloalky 1)-C i-b alkyl-, and NR“Rd / ·, wherein the Ci-e alkyl, 4-14 membered heterocycloalkyl, Ce-i4 ary 1-Ci-e, alkyl-, (5-14 membered heteroaryl)-Ci-6alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6alkyl- of R2are each optionally substituted with 1, 2, or 3 independently selected Rcsubstituents;each Rc2and Rd2are independently selected from H, C i-s alkyl, Ce-w aiyl-Ci-6alkyl-, wherein the C -e alky l and Ce-u ary I-C1-6 alkyl- of Rc2and Rd2are each optionally substituted with 1, 2, or 3 independently selected Rusubstituents;each Rcis independently selected from D, halo, oxo, C -6alkyl, C6-i4 aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heteroc cloalk l, OR34, C(0)NRc4Rd4and NRc4Rd4, wherein the Ci-e alkyl, C6-w aryl,€3-14 cycloalkyl, 5-14 membered heteroaryl, and 4-14 membered heterocycloalkyl, of Rcis optionally substituted with 1, 2, or 3 independently selected RHsubstituents;each R84, Rc4, and Rd4is independently selected from H, Ci-b alkyl, Cj-6haloalkyi, C2-6 alkenyl, and 5-14 membered heteroaryl, wherein the Ci-b alkyl, C2-6 alkenyl, and 5-14 membered heteroaryl, of R®4, R0*, and Rdare each optionally substituted with 1 , 2, or 3 independently selected Rdsubstituents;each RGis independently selected from D, halo, oxo, Ci-e alkyl, CN, NO2, and OH;Cy1is phenyl optionally substituted with 1, 2, or 3 independently selected R substituents;each REis independently selected from D, halo, oxo, Ci-e alkyl, CN, O2 and OH;Cy2is 5-14 membered heteroaryl optionally substituted with 1, 2, or 3 independently selected Rrsubstituents;each R* is independently selected from D, halo, oxo, Ci-6alkyl, C2-6 alkenyl, CN,NO2, and OR34, wherein the C -6alkyl and C2-6 alkenyl of Rfare each optionally substituted with 1, 2, or 3 independently selected Rrisubstituents;each R34is independently selected from H, Ci-6alkyl and Ci-b alkoxy; and each RHis independently selected from D, halo, oxo, CVe alkyl, CN, NO and OH.In some embodiments,X is N;R!IS H or a 5-10 membered heteroaryl optionally substituted with 1, 2, or 3 independently selected RHsubstituents;each RBis independently selected from D, halo, oxo, C -6alkyl, C -6haloalkyi, C2-6 alkenyl, CN, NO2 and OH;R2is selected Ci-s alkyl, 4-10 membered heterocycloalkyl, Cs-io ary l-Ci-6alkyl-, (5-10 membered heteroaryl)-Ci^ alkyl-, (4-10 membered heterocycloalkyl)-Ci-6 alkyl-, and NR“Rd / ·, wherein the Ci-e alkyl, 4-10 membered heterocycloalkyl, Ce-io ary 1-Ci-e, alkyl-, (5-10 membered heteroaryl)-Ci-6alkyl-, and (4-10 membered heterocycloalkyl)-Ci-6alkyl- of R2are each optionally substituted with 1, 2, or 3 independently selected Rcsubstituents;each Rc2and Rd2are independently selected from H, Ci-s alkyl, CV10 asyl-Ci-6alkyl-, wherein the C -e alkyl and Ce-io ary l-Ci-6alkyl- of Rc2and Rd2are each optionally substituted with 1, 2, or 3 independently selected Rusubstituents;each Rcis independently selected from D, halo, oxo, C -6alkyl, C6-io aryl, C3-7cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heteroc cloalk l, OR34, C(0)NRc4Rd4and NRc4Rd4, wherein the Ci-e alkyl, C6-io aryl, C3-?cycloalkyl, 5-10 membered heteroaryl, and 4-10 membered heterocycloalkyl, of Rcis optionally substituted with 1, 2, or 3 independently selected Rrfsubstituents;each R84, Rc4, and Rd4is independently selected from H, Cj-b alkyl, Ci-e haloalkyi, C2-6 alkenyl, and 5-10 membered heteroaryl, wherein the Ci-b alkyl, C2-6 alkenyl, and 5-10 membered heteroaryl, of R®4, R0*, and Rd4are each optionally substituted with 1, 2, or 3 independently selected Rdsubstituents;each RGis independently selected from D, halo, oxo, Ci-e alkyl, CN, NO2, and OH;Cy1is phenyl optionally substituted with 1, 2, or 3 independently selected R substituents;each REis independently selected from D, halo, oxo, Ci-e alkyl, CN, O2 and OH;Cy2is 5-10 membered heteroaryl optionally substituted with 1, 2, or 3 independently selected Rrsubstituents;each R* is independently selected from D, halo, oxo, Ci-6alkyl, C2-6 alkenyl, CN,NO2, and OR34, wherein the C -6alkyl and C2-6 alkenyl of Rfare each optionally substituted with 1, 2, or 3 independently selected Rrisubstituents;each R34is independently selected from H, Ci-6alkyl and Ci-b alkoxy; and each RHis independently selected from D, halo, oxo, CVe alkyl, CN, NO and OH.In some embodiments,X is N;R!is H or nicotinonitriie;R2is pyridinylmethyl, hydroxy(phenyl)methyl, hydroxyetiiylamino(phenyl)ethyl, cyelohexyimethyi, fluorobenzyl, hydroxy (fluorophenyl)methyl, methylpyridinylmetliyl, fluoropyridinylmethyl, melhoxypyridinylmethyl, methylpyrazolylbenzyl- benzoisoxazolylmethyl, methylindazoly!methyl, hydroxyazetidinylmethyl, benzoyl, phenyicyclopropyl, cyano(phenyl)methylamino, tetrahydrofuranyl, or phenyl(pyridin-2- yloxy)methy5;Cy!is cyanophenyl; andCy2is pyrimidinyl, eth lpyrazolyl propylpyrazol l, quinolinyl, iluoropyrimidinyl, pyridinyl, methylpyridinyl, methoxy-methylpyridinyl, pyrazolopyridazinyl, methyloxazolyl, hydroxymethyl-methyloxazolyl, or methoxymethyl-methyloxazolyl.In some embodiments,X is N;R* is H;R2is selected from pyridin-2-ylmethyl, hydroxy(phenyl)methyl, (2~hydroxyethylamino)(phenyl)methyl, cyelohex imethyi, 2-fluorobenzyl, (2- fluorophenyl)(hydrox:y)methyl, (6-methylpyridin-2-yl)methyl, (3-fluoropyridin-2-yl)methyl, (3-methoxypyridin-2-yl)methyl, 2-(l-methyl-lH-pyrazol-4-yl)benzjd, benzo[d]isoxazol-3- ylmethyl, (1 -methyl- lH-indazol-3-yl)methyl, (3-hydroxyazetidin-l-yl)methyl, benzoyl, 1- phenylcyclopropyl, (cyano(phenyl)methyl)amino, tetrahydrofuran-3-yl, phenyl(pyridin-2- yloxy)methyl, 2-fluoro-6-(((3R,4R)-3-fluoro-4-hydroxypyrrolidin-l-yl)methyl)benzyl, 2-((4- carboxypiperidin- 1 -y l)methy l)-6-fluorobenzy 1, 2-fluoro-6-((N - meihyimethy3sulfonamido)methyl)benzyl, 2-((2,5-dioxoimidazolidin-l-yl)methyl)-6- fluorobenzyl, (2,6-difluorophenyl)(hydroxy)methyl, (5-(pyridin-2-yl)-lH-tetrazol-l- yl)methy3, (5-(lH-pyrazol-l-yl)-lH-tetrazol-l-yl)methyl, (5-(thiazo3~4-yl)-lH-tefrazol-l- yllmethyl, (5-methyl-3-(trifluoromethyl)-lH-pyrazol-l-yl)methyl, (3-methylpyridin-2- yl)met3iyl, 2-((l,l-dioxidoisothiazolidin-2-yl)methyl)-6-fluorobenzyl, 2-fluoro-6-((3-methyl- 2,5-dioxoimidazolidin~l-yl)methyi)benzy3, (6-(trifluoromethyl)pyridin-2-yl)methyl, (3- (hydroxymethyl)pyridin-2-yl)methyl, (l-metliyl-lH-pyrazol-3-yl)methyl, and (2- cyanophenoxy)methyl,(3-methyipyridin-2-yi)methoxyr, (6-methylpyridin-2-yl)methoxy, and ((3 -methy lpy ridin-2-y Ijmethy l)amino ;Cy1is cyanophenyl; andCy2is selected from 2,6-dimethylpyridin-4-yl, pyridin-4-yl, 2-methylpyridin-4-yl, 1- carbamoyl- 1 ,2,3,6-tetrahydrop ridin-4-yl, l-carbamoylpiperidin-4-yl, 2-methoxypyridin-4-yl,2-meihoxy-6~methylpyridin-4-yl, 2,6~dimethyipyridin-4~yT~l-oxide, l-ethyl-6-oxo-l,6- dihydropyridin-3-yl, 3-methylpyridin-4-yl, 3-fluoropyridin-4-yl, 3-chloropyridin-4-yl, 3- methoxypyridin-4-y 1, 3 -cyanopyridin -4-yl, 4-carbamoy lpheny 1 , pyrazolo[ 1,5 -a\ pyridin -3 -yl, pyrazolo [ 1 ,5 -b]pyridazin-3 -y 1, 5-methy 1- lH-pyrazol-4-y 1, 1 -ethyl- 1 H-pyrazol-5-y 1, 1- isopropyl-lH-pyrazol-5-yl, 1 -propyl-lH-pyrazol-5-yl, pyrimidin-4-yl, 2,3-dihydro- [l,4]dioxinof2,3-b]pyridin-8-yl, quinolin-5-yl, 5-fluoropyrimidm-4-yl, oxazol-5-yl, 4- methy loxazol-5 -y 1, 4-ethy loxazo!-5 -yl , 4-(hydroxy methy l)-2-methy loxazol-5 -y 3, 4- (methoxymethyl)-2~methy loxazol-5 -yl, 4~(hydroxymeihyl)-2-meihyloxazol~5-yl, 1-ethyl-lH- l,2,3-triazol-5-yl, and cyclopropyl.In some embodiments, the compound is the (S) -enantiomer of one of the preceding compounds, or a pharmaceutically acceptable salt thereof. In some embodiments, the compound is the (R) -enantiomer of one of the preceding compounds, or a pharmaceutically acceptable salt thereof.It is further appreciated that certain features of the invention, which are, for clarity, described in the context of separate embodiments, can also be provided in combination in a single embodiment. Conversely, various features of the invention which are, for brevity, described in the context of a single embodiment, can also be provided separately or in any suitable subcombination.At various places in the present specification, divalent linking substituents are described. It is specifically intended that each divalent linking substituent include both the forward and backward forms of the linking substituent. For example, -NR(CR’R”)n- includes both -NR(CR’R”)n- and -(CR’R”)nNR-. Where the structure clearly requires a linking group, the Markush variables listed for that group are understood to be linking groups.The term“n-membered” where n is an integer typically describes the number of ring forming atoms in a moiety where the number of ring-forming atoms is n. For example, piperidinyl is an example of a 6-membered heterocycloalkyl ring, pyrazolyl is an example of a 5-membered heteroaryl ring, pyridyl is an example of a 6-membered heteroaiyl ring, and 1,2,3,4-tetrahydro-naphthalene is an example of a 10-membered cycloalkyl group.As used herein, the phrase“optionally substituted" means unsubstituted or substituted. The substituents are independently selected, and substitution may be at any chemically accessible position. As used herein, the term“substituted" means that a hydrogen atom is removed and replaced by a substituent. A single divalent substituent, e.g., oxo, can replace two hydrogen atoms. It is to be understood that substitution at a given atom is limited by valency.As used herein, the phrase "each‘variable’ is independently selected from” means substantially the same as wherein“at each occurence‘ variable’ is selected from.”Throughout the definitions, the term "Cn-m” indicates a range which includes the endpoints, wherein n and m are integers and indicate the number of carbons. Examples include C;, Ci-4, Ci-s, and the like.As used herein, the term“Cn-malkyl”, employed alone or in combination with other terms, refers to a saturated hydrocarbon group that may be straight-chain or branched, having n to m carbons. Examples of alkyl moieties include, but are not limited to, chemical groups such as methyl (Me), ethyl (Et), «-propyl (w-Pr), isopropyl (iPr), «-butyl, fe / 7-butyl, isobutyl, sec-butyl; higher homologs such as 2-methyl-l-butyl, «-pentyl, 3-pentyl, «-hexyl, 1 ,2,2- trimethylpropyl, and the like. In some embodiments, the alkyl group contains from 1 to 6 carbon atoms, from 1 to 4 carbon atoms, from 1 to 3 carbon atoms, or 1 to 2 carbon atoms.As used herein, "Cn-malkenyl” refers to an alkyl group having one or more double carbon-carbon bonds and having n to m carbons. Example alkenyl groups include, but are not limited to, ethenyl, «-propeny!, isopropenyt, «-butenyl, sec-butenyl, and the like. In some embodiments, the alkenyl moiety contains 2 to 6, 2 to 4, or 2 to 3 carbon atoms.As used herein,“Cn-malkyn 1” refers to an alkyl group having one or more triple carbon-carbon bonds and having n to m carbons. Example alkyny 1 groups include, but are not limited to, ethynyl, propyn-l-yl, propyn-2-yl, and the like. In some embodiments, the alkynyi motet}'contains 2 to 6, 2 to 4, or 2 to 3 carbon atoms.As used herein, the term“Cn-malkoxy”, employed alone or in combination with other terms, refers to a group of formula-G-alkyl, wherein the alkyl group has n to m carbons. Example alkoxy groups include, but are not limited to, methoxy, ethoxy, propoxy (e.g., «- propoxy and isopropoxy), butoxy (e.g., «-butoxy and tert- butoxy), and the like. In some embodiments, the alkyl group has 1 to 6, 1 to 4, or 1 to 3 carbon atoms.As used herein, the term“amino” refers to a group of formula -NEE.As used herein, the term“aryl”, employed alone or in combination with other terms, refers to an aromatic hydrocarbon group, which may be monocyclic or polycyclic (e.g., having 2, 3, or 4 fused rings). The term“Cn-m aryl” refers to an aryl group having from n to m ring carbon atoms. Aryl groups include, e.g., phenyl, naphthyl, anthracenyl, phenanthrenyl, indanyl, indenyl, and the like. In some embodiments, aryl groups have from 5 to 14 carbon atoms. In some embodiments, the aryl group has from 5 to 10 carbon atoms in some embodiments, the aryl group is phenyl or naphthyl. In some embodiments, the aryl group is phenyl.As used herein,“halo"refers to F, Cl, Br, or I. In some embodiments, a halo is F, Cl, or Br In some embodiments, a halo is F or Cl. In some embodiments, a lialo is F In some embodiments, a halo is Cl.As used herein,“Cn-mhaIoalkoxy” refers to a group of formula -O-haloalkyl having n to m carbon atoms. Example haloalkoxy groups include OCF3and OCF). An example haloalkoxy group is OCHIA. In some embodiments, the haloalkoxy group is fluorinated only. In some embodiments, the alkyl group has 1 to 6, 1 to 4, or l to 3 carbon atoms.As used herein, the term“Cn-n, haloalkyl”, employed alone or in combination with other terms, refers to an alkyl group having from one halogen atom to 2s+l halogen atoms which may be the same or different, where“s” is tire number of carbon atoms in the alkyl group, wherein the alkyl group has n to m carbon atoms. In some embodiments, the haloalkyl group is fluorinated only. In some embodiments, the alkyl group has 1 to 6, 1 to 4, or 1 to 3 carbon atoms. Example haloalkyl groups include CF), C2F5, CHF2, CC13, CHCI2, C2CI3and the like.As used herein, the term“thio” refers to a group of formuIa-SH.As used herein, the term“carbamyl” to a group of formula -C(0)NH2.As used herein, the term“carbonyl”, employed alone or in combination with other terms, refers to a -C(0)- group.As used herein,“cycloalky 1” refers to non-aromatic cyclic hydrocarbons including cyclized alkyl and alkenyl groups. Cycloalkyl groups can include mono- or polycyclic (e.g., having 2, 3, or 4 fused rings) groups, spirocycles, and bridged rings (e.g., a bridged bicycloalkyl group). Ring-forming carbon atoms of a cycloalkyl group can be optionally substituted by oxo or sulfido (e.g., C(O) or C(S)). Also included in the definition of cycloalkyl are moieties that have one or more aromatic rings fused (i.e., having a bond in common with) to the cycloalkyl ring, for example, benzo or thieny l derivatives of cyclopentane, cyclohexane, and the like. A cycloalkyl group containing a fused aromatic ring can be attached through any ring-forming atom including a ring-forming atom of the fused aromatic ring. Cycloalkyl groups can have 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, or 14 ring-forming carbons (i.e., C3-W). hi some embodiments, the cycloalkyl is a C3-14monocyclic or bicyclic cycloalkyl. In some embodiments, the cycloalkyl is a€3-7 monocyclic cycloalkyl. In some embodiments, the cycloalkyl is a C4..7monocyclic cycloalkyl. In some embodiments, the cycloalkyl is a Cwo spirocycle or bridged cycloalkyl (e.g., a bridged bicycloalkyl group). Example cycloalkyl groups include cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclohepty!, cyc!opentenyl, cyclohexenyl, cyclohexadienyl, cycloheptatrienyl, norbomyl,norpinyl, norcamyl, cubane, adamantane, bicyclojd. l. l]pentyl, bicyclo[2. l . l]hexyl, bicyclo[2.2.1 ]heptanyl, bicyclop l. ljheptanyl, bicyclo[2.2.2]octanyl, spiro[3.3]heptanyl, and the like. In some embodiments, cycloalkyl is cyclopropyl, cyclobutyl, cyclopentyl or cyclohexyl.As used herein,“heteroaryl” refers to a monocyclic or polycyclic (e.g., having 2, 3, or 4 fused rings) aromatic heterocycle having at least one heteroatom ring member selected from N, O, S, and B. In some embodiments, the heteroaryl ring has 1 , 2, 3, or 4 heteroatom ring members independently selected from N, O, S and B. In some embodiments, any ring- forming N in a heteroaryl moiety can be an N-oxide. In some embodiments, the heteroaryl is a 5-10 membered monocyclic or bicyclic heteroaryl having 1, 2, 3, or 4 heteroatom ring members independently selected from N, O, S, and B. In some embodiments, the heteroaryl is a 5-6 monocyclic heteroaryl having 1, 2, or 3 heteroatom ring members independently selected from N, O, S, and B. In some embodiments, the heteroaryl is a five -membered or six- membereted heteroaryl ring. A five -membered heteroaryl ring is a heteroaryl with a ring having five ring atoms wherein one or more (e.g., I, 2, or 3) ring atoms are independently selected from N, O, S, and B. In some embodiments, the heteroaryl group contains 3 to 14, 4 to 14, 3 to 7, or 5 to 6 ring-forming atoms. In some embodiments, the heteroaryl group has 1 to 4 ring-forming heteroatoms, I to 3 ring-forming heteroatoms, 1 to 2 ring-forming heteroatoms or 1 ring-forming heteroatom. When the heteroaryl group contains more than one heteroatom ring member, the heteroatoms may be the same or different. Example heteroaryl groups include, but are not limited to, pyridine, pyrimidine, pyrazine, pyridazine, pyrrole, pyrazole, azolyl, oxazole, isoxazole, thiazole, isothiazole, imidazole, furan, thiophene, triazole, tetrazole, thiadiazole, quinoline, isoquinoline, indole, henzothiophene, benzofuran, benzisoxazole, imidazojl, 2-b]thiazole, purine, iriazine, thieno[3,2-b]pyridine, imidazo[l,2- ajpyridine, 1 ,5-naphthyridme, lH-pyrazolo[4,3-b]pyridine, and the like.A five-rnembered heteroaryl is a heteroaryl group having five ring-forming atoms wherein one or more (e.g., 1, 2, or 3) of the ring-forming atoms are independently selected from N, O, B, and S. Exemplary' five-membered ring heteroaryls are thienyl, fuiyl, pyrrolyi, imidazolyl, thiazolyl, oxazolyl, pyrazo!yl, isothiazolyl, isoxazolyl, 1,2,3 -triazolyl, tetrazolyl,1.2.3-thiadiazolyl, 1,2,3-oxadiazolyl, 1,2,4-triazolyl, 1 ,2,4-thiadiazolyl, 1,2,4-oxadiazolyl,1.3.4-triazoiyl, 1,3,4-thiadiazolyl, 1,3,4-oxadiazolyl and l,2-dihydro-i,2-azaborine.A six-membered heteroaryl ring is a heteroaryl with a ring having six ring-forming atoms wherein one or more (e.g., 1, 2, or 3) ring atoms are independently selected from N, O,S, and B. Exemplar}' six-membered ring heteroaiyls are pyridyl, pyrazinyl, pyrimidinyl, triaziny! and pyridazinyl.As used herein,“heterocycloaikyl” refers to monocyclic or polycyclic heterocycles having at least one non-aromatic ring (saturated or partially satur...

Claims

What is claimed is:

1. A compound of Formula (1):or a pharmaceutically acceptable salt thereof; wherein:X is CR3;R* is selected from H, CMalkyl, C2-6 alkenyl, C2-6alkynyl, and CMhaloalkyl;R2is selected from H, D, halo, CMalkyl, CMhaloalkyl, C2-6alkenyl, C2-6 alkynyl, Ce- i4 aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalky 1, C6-! arj'l-C -6 alkyl-, C3- 14 cycloalkyl -CMalkyl-, (5-14 membered heteroaryl)-Ci-6 alkyl-, (4-14 membered heterocycloalky 1)-Ci.5alkyl-, CN, N02, ORa2, SRC NHORa2, C(0)Rb2,C(0)NRc2Rd2, C(0)NRc2(0Ra2), C(0)0Ra2, 0C(0)Rb2, 0C(0)NRc2Rd2, NRc2Rd2,NR' N R'R'i2. NRc2C(0)Rb2, NRc2C(0)0Ra\ NRc2C(0)NRc2Rd2, C(=NRe2)Rb\C(=NRe2)NRc2Rd2, NRc2C(=NRe2)NRc2Rd2, NRc2C(=NRe2)Rb2, NRc2S(0)NRc2Rd2,NRc2S(0)Rb2, NRo2S(0)2Rb2, NRc2S(0)(=NRe2)Rb2, NRo2S(0)2lSlRc2Rd2, S(0)Rb2,SiOjN R· Rd. S(0)2Rb2, S(0)2NRc2Rd2, 0S(0)(=NRe2)Rb2, 0S(0)2Rb2, SF5, P(G)Rf2R8\ 0P(0)(0R!,2)(0R12), R(0)(OK:2)(OR!2), and BRJ2Rk2, wherein the CMalkyl, C2-6alkenyl, CMalkynyl, Ce- aryl, C3-i4cycloalkyl, 5-14 membered heteroaryl, 4-14 memberedheterocycloalkyl, CM* and -C -6 alkyl-, C3-14 cycloalkyl-CMalkyl-, (5-14 membered heteroaryl)-Ci-6alkyl-, and (4-14 membered heterocycloalkyl)-C 1-6 alkyl- of R2are each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected Rcsubstituents;R3is selected from H, 13, halo. C alkyd. C haloalkyl, C alkenyl, C alkynyl, Cs- 14 aryl, CS-Mcycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl,aryl-Ci-6alkyl-, C3-14 cycloalkyl-CMalkyl-, (5-14 membered heteroaryli-CMalkyl-, (4-14 membered heterocycloalkyl)-C -6 alkyl-, CN, NQ2, ORa3, SRa3, NHORa3, C(0)Rb3,C(0)NRc3Rd3, C(0)NRc3(0Ra3), C(0)0Ra3, 0C(0)Rb3, 0C(0)NRc3Rd3, NRc3Rd3,NRc3NRc3Rd3, NRc3C(0)Rb3, NRc3C(0)0Ra3, NRc3C(0)NRc3Rd3, C(=NRe3)Rb3,C(=NRe3)NRc3Rd\ NRc3C(=NRe3)NRc3Rd3, NRc3C(=NRe3)Rb3, NRc3S(0)NRc3Rd3,NRc3S(0)Rb3, NRc3S(0)2Rb3, NR SiO!S NR )RbNRc3S(0)2NRc3Rd3, S(0)Rb3,S(0)NRc3Rd3, S(0)2Rb3, S(0)2NRc3Rd3, 0S(0)(=NRe3)Rb3, 0S(0)2Rb3, SF\, P(0)Rf3Rg3,0P(0)(0Rb3)(0R13), P(0)(0RM)(0Ri3), and BRj3Rk3, wherein the CMalkyl CMalkenyl CMaikynyl Ce-w aryl, C3-Heyeloalkyl, 5-14 membered heteroaryl, 4-14 memberedheierocycloalkyl, Ce-i4 aryl-Cs-6 alkyl-, Cs-w eyeloalkyi-CMalkyl-, (5-14 membered heteroaiyl)-Ci-6 alkyl-, and (4-14 membered heterocycloalkyl)-C alk l- of R3are each optionally substituted with 1 , 2, 3, 4, 5, 6, 7, or 8 independently selected RDsubstituents;Cy1is Ce-Haryl, C3-14eyeloalkyl, 5-14 membered heteroaryl, or 4-14 membered heterocycloalkyl, wherein the Ce-w aryl, C3-14 eyeloalkyl, 5-14 membered heteroaryl or 4-14 membered heteroc cloalkyl is optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected Rhor RMsubstituents;Cy3is C&-34 aryl,€3-14 cycloalkyl, 5-14 membered heteroaryl, or 4-14 membered heierocycloalkyl, wherein the Cg-i aryl,€3-34 eyeloalkyl, 5-14 membered heteroaryl, or 4-14 membered heierocycloalkyl is optionally substituted with l, 2, 3, 4, 5, 6, 7, or 8 independently selected Rpsubstituents;each R32, R“, Rdi, Ra5, R*3, and Rd3is independently selected from H, CMalkyl, CMhaloalkyl, C2-6 alkenyl, C2-6 aikynyl, C6-i4aryl,€3-3eyeloalkyl, 5-14 membered heteroaryl, 4- 14 membered heierocycloalkyl, C&-14 aryl-CMalkyl-, C3-i4cycloalkyl-CMalkyl-, (5-14 membered heteroaryl)-Ci-6alkyl-, and (4-14 membered heterocycloalkyl)-CMalkyl-, wherein the CMalk l, C2-6 alkenyl, CMaikynyl, Ce-u aryl, C3-Meyeloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-i aryl-CMalkyl-, C3-i4cycloalkyl-CMalkyl-, (5-14 membered heteroaryl)-Ci-6alkyl-, and (4-14 membered heierocycloalkyl)-Ci-6alkyl- of Ra2, Rc2, Rd2, R33, Rc3, and Rd3are each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected Rusubstituents;or any Rc2and Rd2attached to the same N atom, together with the N atom to which they are attached, form a 5- or 6-membered heteroaryl or a 4-14 membered heterocycloalkyl group, wherein the 5- or 6-membered heteroaryl or 4-14 membered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected R° substituents;or any R" and Rd3attached to the same N atom, together with the N atom to which they are attached, form a 5- or 6-membered heteroaryl or a 4-14 membered heierocycloalkyl group, wherein the 5- or 6-membered heteroaryl or 4-14 membered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected RGsubstituents;each Rb2and Rb3is independently selected from H, CMalkyl, CMhaloalkyl, C2.&alkenyl, C2-&aikynyl, Ce-w aryl,€3-3 eyeloalkyl, 5-14 membered heteroaryl 4-14 membered heterocycloalkyl Ce-14 aiyl-Ci-6 alkyl-, Cs-u cycloalkyi-Ci-e alkyl-, (5-14 membered heteroaryl)-Ci-6 alkyl-, and (4-14 membered heterocycloalkyl)-CMalkyl-, wherein the CMalkyl, C2-6 alkenyl, C2-6 alkynyi, Ce-u aryl, C3-i4 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C -u aiyl-Ci-6 alkyl-, C3-Hcycloalky 1-Ci-e alkyl-, (5-14 membered heteroaryl)-C 1-6 alkyl-, and (4-14 membered heterocyeloalkyi)-C i-s alkyl- of RD2and Rb3are each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected RGsubstituents; each R52and Re3is independently selected from H, OH, CN, C i-s alkyl, C i-s alkoxy, Ci-e haloalkyl, Cj-e haloalkoxy, C2-6 alkenyl, C2-6 alkynyi, Ce-u aryl, C3-i4 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-u ar l-Ci-6alkyl-, C3-14 cycloalkyl- C 1-6 alkyl-, (5-14 membered heteroai l)-Ci-6alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6alkyl-;each Rg, Rg2, Rfi, and Rg3is independently selected from H, Cj-6alkyl, Ci-6haloalkyl, Ci-ealkoxy, Cj-6 haloalkyl, Ci^haloalkoxy, C2-6 alkenyl, C2-6 alkynyi, Ce-u aiyl, C3-14cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C&.Mary 1-C -e alkyl-, C3-]4cycloalkyl-Ci-6 alkyl-, (5-14 membered heteroaiyll-Cj-e alkyl-, and (4-14 membered heterocy cloalky 1)-C 1.5 alky 1-;each Rl12, Ri2, R!l3, and Rl3is independently selected from H, C i-s alkyl, Ci-6 haloalkyl, €2-5 alkenyl, C2-S alkynyi, C&-14 aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C5-14 aryl-Ci-e, alkyl-, C3-i4 cy cloalky l-Ci-6 alkyl-, (5-14 membered heteroaryl)-C] -6 alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6 alkyl-;each Rj2, Rk2, R , and R*·’ is independently selected from OH, Ci^ alkoxy, and C1-6 haloalkoxy;or any Rj2and RKattached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from Ci-e alky l and Ci-g haloalkyl;or any RJJand R^’ attached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from Ci-6alkyl and Ci-ehaloalkyl;each Rc, R°, RE, RM, RF, and R° is independently selected from D, halo, oxo, Ci-s alkyl, Ci-6haloalkyl, C2-6 alkenyl, C2-6 alkynyi, C6-i4 aryl, C3-j4 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C6-Maryl-Ci-6 alkyl-, C3-i4 cy cloalky 1-C 1-6 alkyl-, (5-14 membered heteroarylVC i-e alkyl-, (4-14 membered heterocycloalkyd)-C i-e alkyl-, CN,S(0)NRc4Rd4, S(0)2Rm, S(0)2NRc+Rd4, 0S(0)(=NRe4)Rb4, 0S(0)2RM, SF5, P(0)Rf4Rg4, 0P(0)(0Rh4)(0R’4), P(0)(0Rtl4)(0Ri4), and BR iC i wherein the CMalkyl, CMalkenyl, CMalkynyl, CKaryl, CB-sr cycloalkyl, 5-14 membered heteroaryl, 4-14 menrheredheterocycloalkyl, Ce-w ar l-Ci-6 alkyl-, C3-14 cycloalkyl-Cw alkyl-, (5-14 membered heteroaryl)-C]-6alkyl-, and (4-14 membered heterocycloalkyl)-CMalkyl- of Rc, RD, RC RM, Rr, and R° are each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected RHsubstituents;each R3+, Rc4, and Rd4is independently selected from H, CM alkyl, CM haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C&.14 aryl, C3-1 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, (M-Maryl-CMalkyl-, Cs-w cycloalkyl-Ci-e alkyl-, (5-14 membered heteroaryl)-C]-6alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6alkyl-, wherein the CM alkyl, CM,alkenyl, CM,alkynyl, Ce-w aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-u aryl-CMalkyl-, CS-Mcycloalky 1-CMalkyl-, (5-14 membered heteroaryl)-Ci.6 alkyl-, and (4-14 membered heterocycloalkyl)-C½ alkyl- of R84, Rc4, and Rd4are each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected Rhsubstituents;or, any R®4and R04attached to the same N atom, together with the N atom to which they are attached, optionally form a 5- or 6-membered heteroaryl or a 4-14 membered heterocycloalkyl group, wherein the 5- or 6-membered heteroaryl or 4-14 membered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected RHsubstituents;each Rb4is independently selected from H, C , alkyl, C , haloalkyl. CM, alkenyl, CM, alkynyl, Ce-u aryl, C3-Mcycloalkyi, 5-14 membered heteroaryl, 4-14 memberedheterocycloalkyl, Ce-w ary 1-CMalkyl-, C3-14 eyeloalkyl-Ci-e alkyl-, (5-14 membered heteroaryl)-C]-6alkyl-, and (4-14 membered heterocycioalkyi)-Cs-6alkyl-, wherein the CMalkyl, CMalkenyl, CMalkynyl, C&.14 aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C5-14 aryl-CM, alkyl-, C3-Mcycloalkyl-CMalk l-, (5-14 membered heteroaryl)-C]-6alkyl-, and (4-14 membered heterocycloalkyi)-Ci-6 alkyl- of Rb4are each optionally substituted with 1 , 2, 3, 4, 5, 6, 7, or 8 independently selected Rrisubstituents; each Re4is independently selected from H, OH, CN, CMalkyl, Cs-ealkoxy, CMhaloalkyl, Ci-ehaloalkoxy, CM alkenyl, C alkynyl, C&-1 aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-u aryl-CMalkyl-, C3-14 cycloalkyl- CMalkyl-, (5-14 membered heteroaiylt-Ci-g alkyl-, and (4-14 membered heterocycloalkyl)-C].6 alkyl-;each Rf4and Rs‘!is independently selected from H, Ci-e alkyl Ci-ealkoxy, Ci-e haloalkyl C;i-f!haloa3koxy, C2-6 alkenyl, C2-6 alkynyl, Ce-w aryl, C3-14 cycloalkyl 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-w aryl-C -6alkyl-, Cs-i cycloalkyi- Ci-6alkyl-, (5-14 membered heteroaryl) -C1-6 alkyl-, and (4-14 membered heterocycloalky 1)-Ci.&alkyl-;each Rh4and R'4is independently selected from H, C -g alkyl, C -g haloalkyl C2-6 alkenyl, C2-6alkynyl, Cg-u aryl, C -u cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-w aryl-Ci-g alkyl-, C -i+cycloalkyl-C -e alkyl-, (5-14 membered heteroaryl)-Ci-6alkyl-, and (4-14 membered heterocycloalky l)-Ci-6alkyl-;each R'4and Rk4is independently selected from OH, C -galkoxy, and Ci-ghaloalkoxy; or, any Rj4and Rk+attached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from Ci-e alky l and C -g haloalkyl;each RHis independently selected from D, halo, oxo, Ci-6alkyl, Ci-6haloalkyl, C2-6alkenyl, C2-6alkynyl, Ce-w aryl, Cj-w cycloalkyl, 5-14 membered heteroaryl 4-14 membered heterocycloalkyl, Cg-u aryl-C1.5alkyl-, C3-1cycloalky I-C1-6alkyl-, (5-14 membered heteroaryl)-Ci-6 alkyl-, (4-14 membered keterocycloalkyl)-Ci-6 alkyl-, CN, NO2, OR®5, SR85,0P(0)(0Rh5)(0Rl5), P(0)(0Rbi)(0Rl5), and BR-'R’ l wherein the Ci-6alkyl, C2-g alkenyl, C2-g alkynyl, Cg-u aryl,€3-14 cycloalky 1, 5-14 membered heteroaryl, 4-14 memberedheterocy cloalkyl, Cg-u aryl-C i-g alkyl-, C3-i4 cycloalkyl-C -6 alkyl-, (5-14 membered heteroaryl)-Ci-6 alkyl-, and (4-14 membered heterocycloalky l)-Ci-6 alkyl- of R1 !are each optionally substituted with 1, 2, 3, or 4 independently selected R1substituents;each R85, Rc5, and Rd5is independently selected from H, Cj-b alkyl, Ci-e haloalkyl, C2-6alkenyl,€2-6alkynyl, Ce-w aryl, C3-14cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C6-i4 aryl-Cs-6alkyl-, Cs-i cycloalkyi-C -g alkyl-, (5-14 membered heteroaryl)-Ci.6alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6alkyl-, wherein the C .g alkyl, C2-6 alkenyl, C2-6 alkynyl, Cg-w aryl, Ci-Kcycloalkyl, 5-14 membered heteroaryd, 4-14 membered heterocycloalkyl, Cg-u aryl-C -6 alkyl-, C3-14cycloalky l-C -6 alkyl-, (5-14 memberedheteroaryl)-C]-6 alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6alkyl- of Ra\ Rc\ and Rd5are each optionally substituted with 1, 2, 3, or 4 independently selected R‘ substituents;or any R05and Rd5attached to the same N atom, together with the N atom to which they are attached, form a 5- or 6-membered heteroaryl or a 4-14 membered heterocycloalkyl group, wherein the 5- or 6-membered heteroaryl or 4-14 membered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected R:substituents;each Rtois independently selected from H, Ci-6alkyl, C2-6 alkenyl, C2-6 alkynyl, CM* aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-u aryi- C 1.6 alkyl-, C3-14cycloalky l-Ci-e alkyl-, (5-14 membered heteroaiyl)-C -6 alkyl-, and (4-14 membered heteroeycloalkyl)-C 1.5 alkyl-, wherein the Cw alkyl, C2-6 alkenyl, C2-6 alkynyl, Ce- i4 aryl, Cs-w cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, CS-M aryl-Ci-6 alkyl-, C3-Mcycloalky 1-Cw alkyl-, (5-14 membered heteroaryl)-C -6 alkyl-, and (4-14 membered heterocycloalky l)-Ci-6alkyl- of Rtoare each optionally substituted with 1, 2, 3, or 4 independently selected R!substituents;each Re- is independently selected from H, OH, CN, Cj-6alkyl, Ci-e alkoxy, Cw haloalkyl, Ci-ehaloalkoxy, C2-6 alkenyl, C2.6 alkynyl, Ce-i4aryl, C3-14cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, CM* ary I-C1-6 alkyl-, C3-14cycloalkyl- C 1-6 alkyl-, (5-14 membered heteroaryl) -Ci-s alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6alkyl-;each Rf:’ and R®5is independently selected from H, Ci-6alkyl, Cj-e alkoxy, CM>haloalkyl, Ci-ehaloalkoxy, C2-6 alkenyl,€2-5 alkynyl, Ce-u aryl, C3-14 cycloalkyl, 5-14 membered heteroary l, 4-14 membered heterocycloalky 1, Ce-u aiyd-Ci-e alkyl-, C3-Htycloalkyl- Ci-6alkyl-, (5-14 membered heteroaiyli-Ci-g alkyl-, and (4-14 membered heterocycioalkyl)-Ci- s alkyl-;each Rtoand R15is independently selected from H, Ci-s alkyl, Ci-b haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C<5-i4aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C w ary 1-Ci-e, alkyl-, C3-14 cycloalkyl-Cw alkyl-, (5-14 memberedheteroaryl)-C]-6alkyl-, and (4-14 membered heterocycioaikyi)-Ci-6 alkyl-;each Rj5and R1* is independently selected from OH, Ci-galkoxy, and C -ehaloalkoxy ; or, any Rj5and RKattached to the same B atom, together with the B atom to wirich they are attached, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1 , 2, 3, or 4 substituents independently selected from C -.-e alkyl and Cue haloalkyl;each REis independently selected from D, halo, oxo, Ci-6 alkyl, Cue haloalkyl, C2-6 alkenyl, C2-6alkynyl, C&-J4 aryl, C3-14cycloalkyl, 5-14 membered heteroaryl, 4-14 memberedheterocycloalkyl, Ce-w aryl-Ci-e alkyl-, Cj-i+ cycloalkyl-Cj-e alkyl-, (5-14 memhered heteroaryl)-Cj-6alkyl-, and (4-14 membered heterocycloa3kyl)-Ci-6alkyl-, CN, NO2, ORa6, SR36, NHORa6, C(0)Rb6, C(0)NRc6Rd6, CfO)NRc6(ORa6), C(0)0Rai>, 0C(0)Rb6,0C(0)NRc6Rd6, NRc6Rd6, NRc5NRc6Rd6, NRc6C(0)Rfc6, NRc6C(0)0Ra6, NRc5C(0)NRc5Rd6, C(=NRe6)Rb6, C(=NRe6)NRc6Rd6, NRc6C(=NRe6)NRc6Rd6, NRc6C(=NRe6)Rb6, NRc6S(0)Rb6, NRe6S(0)NRc6Rd6, NRc6S(0)2Rb6, NRo6S(0)(=NRe6)Rb6, NRc6S(0)2NRc6Rd6, S(0)Rb6, S(0)NRc5Rd5, SsOi -R1". S(0)2NRc5Rd6, 0S(0)(=NRe6)Rb6>0S(0)2Rb6, SF5, P(0)RffiRs6, QP(0)(0Rb6)(0Rl6), P(0)(0R“6)(0R15), and BR'6Rk6, wherein the Ci-6alkyl C2-6alkenyl C2-6alkynyl, C&.14 aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 memberedheterocycloalkyl, Ce-i4 aryt-Cj-6 alkyl-, Cs-u cycloalkyl-Ci-e alkyl-, (5-14 membered heteroaryl)-C]-6 alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6 alkyl- of Rlare each optionally substituted with 1 , 2, 3, or 4 independently selected R / ' substituents;each R36, R06, and Rd6is independently selected from H, C1-6 alkyl C1-6 haloalkyl C2-6alkenyl, C2-6alkynyl, C&-14 aryl, C3..14 cycloalky 1, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-u aryl-C i-e alkyl-, C3-i4cycloalkyl-Ci-6 alkyl-, (5-14 membered heteroaryl)-Ci-6alkyl-, and (4-14 membered heterocycloalky 1)-C 1.6 alkyl-, wherein the Ci.&alkyl, C2-6 alkenyl, C2-6 alkynyl, C&-J4 aryl, CJ-Mcycloalky 1, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-u aryl-Ci-e alkyl-, Cs-u cycloalkyl-Cj-e alkyl-, (5-14 membered heteroaryl)-Ci-6alkyl-, and (4-14 membered heterocycloalky 1)-C 1.6 alkyl- of Ra5, RCR, and RdRare each optionally substituted with 1, 2, 3, or 4 independently selected RJsubstituents; or any Rc6and Rdoattached to the same N atom, together with the N atom to which they are attached, form a 5- or 6-membered heteroary l or a 4-14 membered heterocycloalkyl group, wherein the 5- or 6-membered heteroaryl or 4-14 membered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected RJsubstituents;each Rbbis independently selected from H, Cj-6alkyl, Cj-6haloalkyl C2-s alkenyl, C2-6 alkynyl, C&.14 aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 memberedheterocycloalkyl, CMary I-C1-& alkyl-, C3-14 cycloalkyl-Ci-e alkyl-, (5-14 membered heteroaryl)-C]-6 alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6 alkyl-, wherein the Cj-e alkyl, C2-&alkenyl, C2-f,alkynyl, Ce-w aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C6-Haryl-Ci-e alkyl-, CVw cycloalkyl-C i-e alkyl-, (5-14 membered heteroaryl)-Ci.6 alkyl-, and (4-14 membered heterocycloalkyl)-C½alkyl- of R66are each optionally substituted with 1 , 2, 3, or 4 independently selected R1substituents;each R®6is independently selected from H, OH, CN, Ci-e alkyl, Ci-e alkoxy, Ci-e haloalkyl, Cj-ehaloalkoxy, C2-6 alkenyl, C2-e alkynyl, C&-J4 aryl, C3-14 cycloalky 1, 5-14membered heteroaryl, 4-14 membered heterocycloalkyl, CM4 ary l-Ci-6alkyl-, C3-i4cycloalkyl- C -6alkyl-, (5-14 membered heteroaryli-Ci-f, alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6alkyl-;each Rf6and R86is independently selected from H, Ci-6alkyl, Ci^ alkoxy, Ci-e haloalkyl, Ci-ehaloalkoxy, C2-6 alkenyl, C2-6 alkynyl, Ca-u aryl, C3-i4cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-ir aiyl-Ci-6alkyl-, C3-14 cycloalkyl- Ci-f,alkyl-, (5-14 membered heteroaryl) -C -6alkyl-, and (4-14 membered heterocycioalkyl)-C -6alkyl-;each Rh6and R” is independently selected from H, C1.6 alkyl, Ci-b haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C&-Karyl, C-t-u cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-w aryl-Ci-6 alkyl-, C -i+cycloalkyl-C -e alkyl-, (5-14 memberedheteroaryl)-C]-6 alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6 alkyl-;each Rj6and Rk6is independently selected from OH, C -galkoxy, and Ci-shaloalkoxy; or, any Rj6and Rk6attached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from C 1.5 alkyl and Che haloalkyl;each RJis independently selected from D, halo, oxo, C -6 alkyl, C -6 haloalkyl, C2-f,alkenyl, C2-6 alkynyl, Ce-u aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce- aryl-C 1 -5 alkyl-, C3-14 cycloalky I-C1-6 alkyl-, (5-14 memberedheteroaryl)-C 1-6 alkyl-, and (4-14 membered heteroeyeloalky4)-Ci-6 alkyl-, CN, N02, ORa7, SRa7, NHORa7, C(0)Rb7, C(G)NRc7Rd7, C(0)NRc7(0Ra7), C(0)0Ra7, 0C(0)Rb7,GCsOiX R-'Rd. NRc7Rd7, NRc7NRc7Rd7NRc7C(0)Rb7, NRc7C(0)0Ra7, NRc7C(0)NRc7Rd7, C(=NRe7)Rb7, C(=NRe7)NRc7Rd7, NRc7C(=NRe7)NRc7Rd7, NRc7C(=NRe7)Rb7, NRc7S(0)Rb7, NRc7S(0)NRc7Rd7, NRc7S(0)2Rb7, NRc7S(0)(=NRe7)Rb7, NRc7S(0)2NRc7Rd7, S(0)Rb?, SiOiNR R1S(0)2Rb7, S(0)2NRc7Rd7, 0S(0)(=NRe7)Rb7, 0S(0)2Rb7, Si·',. P(0)Ri7Rg7, 0P(0)(0Rh7)(0R17), P(0)(0Rb7)(0R17), and BRj7Rt7, wherein the Ci-5alkyl, C2.5alkenyl, C2.5alkynyl, Ct,-u aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 memberedheterocycloalkyl, Ce-w aryl-C 1-6 alkyl-, Cs-i+cycloalkyl-C -e alkyl-, (5-14 memberedheteroaryl)-C].6alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6 alkyl- of RJare each optionally substituted with 1, 2, 3, or 4 independently selected RKsubstituents;each Ra / , Rc', and Rd' is independently selected from H, Ci-6alkyl, Ci-6haloalkyl, C2.6alkenyl, C2-&alkynyl. CM* aryl, Cj-w cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-ir aiyl-Ci-6 alkyl-, Cs-u cycloalkyl-Ci-e alkyl-, (5-14 memberedheteroaryl)-Ci-6alkyl-, and (4-14 membered heterocycloalkyl)-C i-e alkyl- wherein the Ci-&alkyl,€2-6 alkenyl, C2-6alkynyl, Cg-u aiyd, C3-i4 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Cgwi ary 1-Ci-g alkyl-, C3-Mcycloalkyl-Ci-6alkyl-, (5-14 membered heteroaryl)-C 1-6 alkyl-, and (4-14 membered heterocyeloalkyl)-Ci-s alkyl- of Ra7, Rc', and Rd' are each optionally substituted with 1, 2, 3, or 4 independently selected RKsubstituents; or any Rc7and Rd / attached to the same N atom, together with the N atom to which they are attached, form a 5- or 6-membered heteroaryl or a 4-14 membered heterocycloalkyl group, wherein the 5- or 6-membered heteroaryl or 4-14 membered heterocycloalkyl group is optionally substituted with 1 , 2, 3, or 4 independently selected R substituents;each Rb?is independently selected from H, Ci-e alkyl, Ci-e haloalkyl, Cb-g alkenyl,€2-5 alkynyl, Cg-w aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 memberedheterocycloalkyl, Cb-w aryl-Cb-g alkyl-, C -i+cycloalkyl-Ch-g alkyl-, (5-14 membered heteroaryl)-C] -6 alkyl-, and (4-14 membered heterocycloalkyl)-Ci-g alkyl-, wherein the (b-g alkyl, C2-6 alkenyl, C2-6 alkynyl, Cg-u aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C .14 ar l-Ci-6 alkyl-, C3.14 cycloalkyl-Ci-g alkyl-, (5-14 membered heteroaryl)-Ci-g alkyl-, and (4-14 membered heterocycloalkyl)-Ci-g alkyl- of Rfc7are each optionally substituted with 1, 2, 3, or 4 independently selected RKsubstituents;each Re7is independently selected from H, OH, CN, Ci-g alkyl, C2-6 alkenyl, Cb-g alkoxy, Cb-g haloalkyl, Ci-ghaloalkoxy, C2-6 alkynyl, Cg-14 aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, and 4-14 membered heterocycloalkyl;each R17and Rs?is independently selected from H, Ci-g alkyl, (b-g alkoxy, Ci-g haloalkyl, Ci-ghaloalkoxy, C2-6 alkenyl, C2- alkynyl, Cg-w aryl, C3-i4cycloalkyl, 5-14 membered heteroary l, 4-14 membered heterocycloalkyl, C -u aryl-Cb-g alkyl-, Cb-u cycloalkyl- Ci-g alkyl-, (5-14 membered heteroaryl)-C]-g alkyl-, and (4-14 membered heterocydoalkyl)-(b- g alkyl-;each Rh7and Rl7is independently selected from H, Ci-g alkyd, Ci-g haloalkyl, Cb-g alkenyl, C2-6 alkynyl, Cg-j4aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-w ary 1-Ci-g alkyl-, C -i+cycloalkyl-Ci-g alkyl-, (5-14 membered heteroaryl)-C]-g alkyl-, and (4-14 membered heterocycloalkyi)-Ci-g alkyl-;each RJ / and R*' is independently selected from OH, Ci-g alkoxy, and C -ghaloalkoxy ; or, any RJ' and Rk / attached to the same B atom, together with the B atom to -which they are attached, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1 , 2, 3, or 4 substituents independently selected from Cb-g alkyd and Ci-g haloalkyl;each RKis independently selected from H, D, OH, halo, oxo, CN, C(Q)OH, NH2,NO2, SF5, C -g alkyl, Ci-g alkoxy, Ci-ghaloalkoxy, Ci-g haloalkyl, Cb-g alkenyl, Cb.-g alkynyl, Cg-14 aryl, Cs-w cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, CS-Maryl-Ci-6 alkyl-, C3-Mcycloalkyl-Cw alkyl-, (5-14 membered heteroaryl)-Cj-6 alkyl-, and (4-14 membered heterocycloalkyl)-C 1-6 alkyl-; andwherein any heteroaryl group of any of the above-recited substituents optionally comprises an N -oxide on any ring-forming nitrogen.or a pharmaceutically acceptable salt thereof; wherein:X is N;R' is selected from H, Cj-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and Cw haloalkyl;R2is selected from H, D, halo, C1 -6 alkyl, C1 -6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, Ce- 14 aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl,€5-1 aryl-Ci-6 alkyl-, C3-14 cycloalky 1-Cw alkyl-, (5-14 membered heteroaryl)-Ci-6 alkyl-, (4-14 membered heterocycloalkylVCi-e alky l-, CN, NO2, ORa2, SRaz, NHOR3, C(0)Rbz,C(0) Rc2Rd2, C (0)NRc2(0Ra2), C(0)0Ra2, 0C(0)Rb2, 0C(0)NRc2Rd2, NRc2Rd2,NRc2NRc2Rd2, NRc2C(0)Rb2, NRc2C(0)0Ra2, NRc2C(0)NRc2Rd2, C(=NRe2)Rb2,C(=NRe2)NRc2Rd2, NRc2C(=NRc2)NRc2Rd2, N R C( \ R'"iRh. NRc2S(0)NRc2Rd2,XRc2S(0)Rb2, XRc2S(0)2Rb2, NRc2S(0)(=NRe2)Rb2, NRc2S(0)2NRc2Rd2, S(0)Rb2,S(0)NRc2Rd2:, S(0)2Rb2, S(0)2NRc2Rd2, 0S(0)(=NRe2)Rb2, 0S(0)2Rb2, SFs, P(0)R&:Rg2, 0R(0)((1M)((M!2), P(0)(0Ri,2)(0R12), and BRJ2Rk2, wherein the Ci-e alkyl, C2-6 alkenyl, C2-6alkynyl, CKaryl,€3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 memberedheterocycloalkyl, Ce-w ary l-Ci-6 alkyl-, C3-14cycloalkyl-Ci-e alkyl-, (5-14 membered heteroaryl)-Ci-6 alkyl-, and (4-14 membered heterocycloalky l)-Ci-6alkyl- of R2are each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected RLsubstituents;Cy1is C&-34 aryl, C -u cycloalkyl, or 5-14 membered heteroaryl, wherein the Ce-n aryl, C3-i4 cycloalkyl, or 5-14 membered heteroaryl is optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected Rbor RMsubstituents;Cy2is C&-34 aryl,€3-14 cycloalkyl, 5-14 membered heteroaryl, or 4-14 membered heterocycloalkyl, wherein the Ce-u aryl, C3-14cycloalkyl, 5-14 membered heteroaryl, or 4-14membered heterocycloalkyl is optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected Rbsubstituents;each R“, R°2, and Rd2is independently selected from H, C i-s alkyl, Ci-s haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C&-14 aryd, C3..14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-u aryl-C i-e alkyl-, C3-i4 cycloalkyl-Cj-6 alkyl-, (5-14 membered heteroaryl)-Ci-6 alkyl-, and (4-14 membered heterocycloalky 1)-C R> alkyl-, wherein the CM alkyl, C2-6 alkenyl, C2-6 alkynyl, Ci.-u aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-u aryl-Ci-e alkyl-,€3-54 cycloalkyl-C -6 alky' 1-, (5-14 membered heteroaryl)-Ci-6 alkyl-, and (4-14 membered heterocycloalky l)-Ci-6 alkyl- of Ra2, Rc, and Rdiare each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R° substituents;or any Rc2and Rd2attached to the same N atom, together with the N atom to which they are attached, form a 5- or 6-membered heteroaryl or a 4-14 membered heterocycloalkyl group, wherein the 5- or 6-membered heteroaryl or 4-14 membered heterocycloalkyl group is optionally substituted with 1 , 2, 3, or 4 independently selected R^1substituents;each Rb2is independently selected from H, C.-s alkyl, C.-s haloalkyl, C2.&alkenyl, C2-&alkynyl, Ci.-n aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 memberedheterocycloalkyl, Ce-w ary i-C 1-6 alkyl-, Cs-ir cycloalkyl-Cj-e alkyl-, (5-14 memberedheteroaryl)-Ci-6alkyl-, and (4-14 membered heterocycloalky 1)-C 1.6 alkyl-, wherein the Ci.&alkyl, C2-e alkenyl, C2-e alkynyl, C&-Karyl,€3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Cs-ir aryl-Cw alkyl-, C3-14 cycloalkyl-Ci-e alkyl-, (5-14 membered heteroaryl)-C ^ alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6 alkyl- of R°2are each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R<Jsubstituents; each R is independently selected from H, OH, CN, C.-s alkyl, C.-s alkoxy, Ci-6 haloalkyl, Ci-ehaloalkoxy, C2-6 alkenyl, C2-&alkynyl, Ca-u aryl, CB-Mcycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalky 1, Ce-u aryl-C i-b alkyl-, C3-14 cycloalky 1- Ci-f,alkyl-, (5-14 membered heteroar l) -Cj-6 alkyl-, and (4-14 membered heterocycloalkyl)-Cj- 6 alkyl-;each Rcand Rg2is independently selected from H, Ci-e alkyl, Ci-b haloalkyl, Cj-6alkoxy, Ci^ aloalkyl, Ci-ehaloalkoxy, C2-6 alkenyl, C2-6alkynyl, CS-Maryd, Cs-wcycloalkyl, 5-14 membered heteroary l, 4-14 membered heterocycloalkyl, CM* aryl-C 1-6 alkyl-, C3 -14 cycloalkyl-Ci-6alkyl-, (5-14 membered heteroaryl)-Ci-6alkyl-, and (4-14 membered heterocyc!oalkyl)-C 1-6 alkyl-:each Rh2and Rl3is independently selected from H, Ci-s alkyl, Ci-6haloalkyl, C2-6alkenyl, C2-6 alky nyl, Ce-w aryl, C3-14cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, (h-w aryt-C -6alkyl-, Cs-w eyeloalkyi-Ci-e alkyl-, (5-14 membered heteroaiyl)-Ci-6alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6alkyl-;each Rj2and R2is independently selected from OH, C -s alkoxy, and Ci-shaloalkoxy; or any Rj2and Rk2attached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from Ci-6alkyl and C 1-6 haloalkyl; each Rc, RE, RM, Rr, and R° is independently selected from D, halo, oxo, Ci-e alkyl, Ci-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, Ch-w aryl, C3-14 cyctoalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C&04 ary l-Ci-s alkyl-, Cs-ir cycloalkyl-Ci-e alkyl-, (5-14 membered heteroaryl)-Ci^, alkyl-, (4-14 membered heterocycloalkyl)-Ci^, alkyl-, CN,0P(0)(0Rh4)(0Ri4), P(0)(0RM)(0Ri4), and BRj+Rk4, wherein the Ci-6alkyl, C2-6 alkenyl, C2-6alkynyl, C&.14aryl, C3-14cycloalkyl, 5-14 membered heteroaryl, 4-14 memberedheterocycloalkyl, (h-w aryl-Cs-6alkyl-, Cs-w eyeloalkyi-Ci-e alkyl-, (5-14 membered heteroaryl)-Ci.6 alkyl-, and (4-14 membered heterocycloalkyl)-C½ alkyl- of Rc, Rb, RM, Rr, and Ruare each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected RHsubstituents;each Ra4, Rc4, and Rd4is independently selected from H, Ci-e alkyl, Ci-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, Ce-w aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce- aryl-C 1.5 alkyl-, C3-14 cycloalky I-C1-6 alkyl-, (5-14 membered heteroaryl)-Ci-6 alkyl-, and (4-14 membered keterocycloalkyl)-C i-e alkyl-, wherein the Ci-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, Ce-i+ aryl, Cs-u cycloalkyi, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-w aryl-Ci-e alkyl-, C3-34 cycloalky l-Ci-s alkyl-, (5-14 membered heteroaryl)-C 1-6 alkyl-, and (4-14 membered heteroeycloaikyi)-C i-6 alkyl- of Ra4, Rc4, and Rd4are each optionally substituted with 1, 2, 3, 4, 5, 6, 7, or 8 independently selected Rhsubstituents;or, any Rc4and Ra4attached to the same N atom, together with the N atom to which they are attached, optionally form a 5- or 6-membered heteroaryl or a 4-14 memberedheterocycloalkyl group, wherein the 5- or 6-membered heteroaryl or 4-14 membered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected RMsubstituents;each Rb4is independently selected from H, CMalkyl, C haloaikyl, C2-6 alken l, C2.6 alkynyl, Ca-u aryl, C3-i4 cycloalkyl, 5-14 membered heteroaryl, 4-14 memberedheterocycloalkyl, C6-14 aryl-Ci-6alkyl-, Cs-u cycloalkyl-Ci-e alkyl-, (5-14 membered heteroaryl)-Ci-6 alkyl-, and (4-14 membered heterocycloalkyl)-CMalkyl-, wherein the CM alkyl, C2-6 alkenyl, C2-6 alkynyl, Ce-u aryl, C3-i4 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Cs-w ary 1-CMalkyl-, C3-14 cycloalky l-Ci-6 alkyl-, (5-14 membered heteroaryl)-C alkyl-, and (4-14 membered heterocyeloalkyl)-C[-s alkyl- of RD4are each optionally substituted with 1 , 2, 3, 4, 5, 6, 7, or 8 independently selected RHsubstituents; each R®4is independently selected from H, OH, CN, CM, alkyl, CM, alkoxy, CMhaloaikyl, Cj-ehaloalkoxy, C2-6 alkenyl, C2-6 alkynyl, Ce-u aryl, C3-i4 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-i4 aryl-Ci-6alkyl-, C3..14 cycloalky 1- C i-6alkyl-, (5-14 membered heteroaryl)-C alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6alkyl-;each Rf4and R*4is independently selected from H, CM, alkyl, CM alkoxy, Ci-6haloaikyl, Ci-ehaloalkoxj', C2-6 alkenyl, C2-6 alkynyl, Ce- aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalky 1, Ce-i4 aryd-Ci-e alkyl-, C3-14 cycloalky 1- CM alkyl-, (5-14 membered heteroaryl)-C]-6alkyl-, and (4-14 membered heterocycloalkyl)-Ci- 6 alkyl-;each R1*4and Rl4is independently selected from H,alkyl.haloaikyl, C2-6 alkenyl, C2-6alkynyl, Ce-u aryl, C3-14 cycloalkyl, 5-14 membered heteroaryi, 4-14 membered heterocycloalkyl, Ce-w ary l-Cw alkyl-, C3-14 cycloalkyl-CMalkyl-, (5-14 membered heteroaryl)-Ci-6alkyi-, and (4-14 membered heterocycloalkyi)-Cs-6alkyl-;each R·'4and Rk4is independently selected from OH, Ci-ealkoxy, and Ci-ehaloalkoxy ; or, any Rj+and Rk4attached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from CMalkyl and C haloaikyl;each RHis independently selected from D, halo, oxo, CMalkyl, CMhaloaikyl, C2-6 alkenyl, C2-6 alkynyl, C&-14 aryl, C3..1+ cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-u aryl-C alkyl-, C3-i4 cycloalkyl-Ci-6 alkyl-, (5-14 membered heteroaryl)-Ci-6alkyl-, (4-14 membered heterocycloalky 1)-CMalkyl-, CN, NO2, OR85, SR85, NHQRa5, C(0)Rb5, C(0)NRc5Rd5, C(0)NRc5(0Ra5), C(0)0Ra5, 0C(0)Rb5, 0C(0)NRc5Rd5,NRc?'Rd5, NRc5NRc5Rd5_ NRc5C(0)Rb5, N R'XiOiOR ". NRc5C(0)NRc5Rd5, C(=NRe5)Rb5,C (=NRe5)NRc5R<15, NRc5C(=NRc5)NRc5Rd5, NRc5C(=NRe5)Rb5, NRc5S(0)Rb\NRc5S(0)NRc5Rd5, NRc5S(0)2Rb5, NRcSS(0)(=NReS)Rb5, NRc5S(0)2NRc5Rd5, S(0)Rb5, S(0)NRc5Rd5, S(0)2Rb5, S(0)2NRc5Rd5. OSiOx M K \ OSiO! -R1". SF5, PiOiR 'K". OPIOXOR^XOR15), P(0)(0R!LS)(0Ri5), and BR R*5, wherein the CMalkyl, C2-6 alkenyl, C2-6 alkynyl, 65-14 aryl, 63-14 cycloalkyl, 5-14 membered heteroaiyl, 4-14 memberedheterocycloalkyl, CMAary 1-Ci-e, alkyl-, C3-14 cycloalkyl-Ci-e alkyl-, (5-14 membered heteroaryl)-C]-6alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6alkyl- of Rhare each optionally substituted with 1, 2, 3, or 4 independently selected R1substituents;each Ra5, R°5, and Rd5is independently selected from H, C i-s alkyl, 6 1-5 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, 65-14 aiyd, 63-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, CM* aryl-6 [-6 alkyl-, 63-1 cycloalkyl-Ci-e alkyl-, (5-14 membered heteroaryl)-6i-6 alkyl-, and (4-14 membered heterocycloalky 1)~6R>alkyl-, wherein the 61-6 alkyl 62-s alkenyl, 62-s alkynyl, 65-14 aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, 65-114 aryl-61-6 alkyl-, 63-14 cycioalkyl-Oi-6 alkyl-, (5-14 membered heteroaryl)-Ci-5 alkyl-, and (4-14 membered heterocycloalky 1)-C 1.5 alkyl- of R35, Rcd, and Rdaare each optionally substituted with 1, 2, 3, or 4 independently selected R!substituents;or any R05and Rdaattached to the same N atom, together with the N atom to winch they are attached, form a 5- or 6-membered heteroaryl or a 4-14 membered heterocycloalkyl group, wherein the 5- or 6-membered heteroaryl or 4-14 membered heterocy cloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected R!substituents;each Rtois independently selected from H, 61 -5 alkyl, 62-6alkenyl, 62-f!alkynyl, Ce-w ary l, 63-14cycloalky 1, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, 65-14axyl- Ci-6 alkyl-, C3-14eyeloalkyl-Ci-e alkyl-, (5-14 membered heteroaryl)-6i-5 alkyl-, and (4-14 membered heterocycloalkyl)-6i-6alkyl-, wherein the Cs-6alkyl, C2-&alkenyl, C2-6 alkynyl, Ce¬ltand, 63.14cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl,5-1aryl-61-6 alkyl-, C3-14cycloalkyl-C1-5 alkyl-, (5-14 membered keteroaryl)-Ci-6 alkyl-, and (4-14 membered heterocycloalky 1)-6I-6alkyl- of Rb5are each optionally substituted with 1, 2, 3, or 4 independently selected R1substituents;each Re5is independently selected from H, OH, 6N, 64-5alkyl, Cs-ealkoxy, 61-5haloalkyl, 6i^haloalkoxy, 62-5alkenyl, 62-5alkyny l, 65-14aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, 65-14aryd-Ci-e alkyl-, 63-14cycloalkyl- 61-6 alkyl-, (5-14 membered heteroaiydt-Ci-g alkyl-, and (4-14 membered heterocycloalkyl)-6i- 5 alkyl-;each Rf5and RS3is independently selected from H, Ci-e alkyl Ci-e alkoxy, Ci-e haloalkyl C;i-f!haloa3koxy, C2-6 alkenyl, C2-6 alkynyl, Ce-w aiyl, C3-14 cycloalkyl 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl,€6- aryl-C -6alkyl-, Cs-i cycloalkyi- Ci-6alkyl-, (5-14 membered heteroaryl) -C1-6 alkyl-, and (4-14 membered heterocycloalky 1)-Ci.&alkyl-;each R115and R1'is independently selected from H, C -g alkyl, C -g haloalkyl C2-6 alkenyl, C2-6 alkynyl, Cg-u aryl, C -u cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-w aryl-Ci-g alkyl-, C -i+ cycloalkyl-C -e alkyl-, (5-14 membered heteroaryl)-Ci-6alkyl-, and (4-14 membered heterocycloalky l)-Ci-6alkyl-;each RJiand R’° is independently selected from OH, C -g alkoxy, and C i-ghaloalkoxy; or, any Rj5and Rk?' attached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from Ci-e alky l and C -g haloalkyl;each R1is independently selected from D, halo, oxo, C .-g alkyl, C .-g haloalkyl, C2-6 alkenyl, C2-6 alkynyl, Ce-w aryl, Cj-w cycloalkyl, 5-14 membered heteroaryl 4-14 membered heterocycloalkyl, Cg-u aryi-C 1.5 alkyl-, C3-1 cycloalky I-C1-6 alkyl-, (5-14 membered heteroaryl)-Ci-6 alkyl-, and (4-14 membered heterocycloalkyl)-C [-6 alkyl-, CN, NO2, ORa6,0P(0)(0Rh6)(0Rl6), P(0)(0Rb6)(0R16), and BRJ6R“, wherein the C -6alkyl, C2-g alkenyl, C2-g alkynyl, Cg-u aryl,€3-14 cycloalky 1, 5-14 membered heteroaryl, 4-14 memberedheterocycloalkyl, Cg-u aryl-C i-g alkyl-, C3-i4cycloalkyl-C -6 alkyl-, (5-14 membered heteroaryl)-Ci-6alkyl-, and (4-14 membered heterocycloalky l)-Ci-6alkyl- of R1are each optionally substituted with 1, 2, 3, or 4 independently selected RJsubstituents;each R86, Rcf>, and Rd6is independently selected from H, Cj-b alkyl, Ci-e haloalkyl, C2-6 alkenyl,€2-6 alkynyl, Ce-w aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl C6-i4 aryl-Cs-6alkyl-, Cs-i cycloalkyi-C -g alkyl-, (5-14 membered heteroaryl)-Ci.6alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6alkyl-, wherein the C .g alkyl, C2-6 alkenyl, C2-6 alkynyl, Cg-w aryl, CJ-M cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Cg-u aryl-C -6 alkyl-, C3-14 cycloalky l-Ci^ alkyl-, (5-14 memberedheteroaryl)-C -6 alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6alkyl- of Ra6, Rc5, and Rd6are each optionally substituted with 1, 2, 3, or 4 independently selected R' substituents;or any Rc6and Rd6attached to the same N atom, together with the N atom to which they are attached, form a 5- or 6-membered heteroaryl or a 4-14 membered heterocycloalkyl group, wherein the 5- or 6-membered heteroaryl or 4-14 membered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected RJsubstituents;each Rb6is independently selected from H, Ci-e alkyl, Ci-e haloalkyl, C2-6 alkenyl, C2-6 alkynyl, Ce- ar d, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 memberedheterocycloalkyl, Cg-w aryl-C 1.5 alkyl-, C3-14 cycloalky l-Ci-g alkyl-, (5-14 membered heteroaryl)-C 1-6 alkyl-, and (4-14 membered heterocycloaikyi)-Ci-6 alkyl-, wherein the Ci-s alkyl, C2-6 alkenyl, C2-6 alkynyl, Ce-u aryd, C3-i4 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Cg-u aryl-Ci-g alkyl-, C3-Mcycloalky 1-Cj-e alkyl-, (5-14 membered heteroaryl)-Ci-6alky 1-, and (4-14 membered heterocycloaikyi)~Ci-g alkyl- of RBbare each optionally substituted with 1, 2, 3, or 4 independently selected RJsubstituents;each R66is independently selected from H, OH, CN, Cj-g alkyl, Cfr-g alkoxy, Cw haloalkyl, Ci-ghaloalkoxy, C2-6 alkenyl, C2.6 alkynyl, Ce-i4 aiyl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C&-14 ar l-Ci-6 alkyl-, C3-14 cycloalkyl- Ci-g alkyl-, (5-14 membered heteroaiyd)-Ci-g alkyl-, and (4-14 membered heterocycloalkyl)-Ci- g alkyl-;each Rfband Rg5is independently selected from H, Cfr-g alkyl, Cs-g alkoxy, Ci-g haloalkyl, Ci-ghaloalkoxy, Cb-g alkenyl, C245 alkynyl, Cg-u aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Cg-u aryl-Cb-g alkyl-, C3-14 cycloallcyl- Ci-6alkyl-, (5-14 membered heteroaiyll-Ci- alkyl-, and (4-14 membered heterocycloalkyl)-C].g alkyl-;each Rhband R16is independently selected from H, Ci-g aikyd, Ci-g haloalkyl, C2-6 alkenyl, C2-6 alkynyl, Cg-j4aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, C -w ary I-C1-& alkyl-, C3-14 cycloalkyl-Cw alkyl-, (5-14 membered heteroaryl)-C]-6alkyl-, and (4-14 membered heterocycioalkyl)-Ci-g alkyl-;each Rj5and Rteis independently selected from OH, Ci-galkoxy, and Cj-ghaloa!koxy ; or, any Rj6and Rk5attached to the same B atom, together with the B atom to wiiich they are attached, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1 , 2, 3, or 4 substituents independently selected from Cb-g aikyd and Ci-g haloalkyl;each R3is independently selected from D, halo, oxo, Cj_g alkyl, Cj_g haloalkyl, Cb-g alkenyl, C?_-g alkynyl, Cg-u aryd, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 memberedheterocycloalkyl, Ce-w aryl-Ci-e alkyl-, C -i+ cycloalkyl-C -e alkyl-, (5-14 memhered heteroaryl)-C -6alkyl-, and (4-14 membered heterocycloalkyl)-Ci-6alkyl-, CN, NO2, ORa7, SKa7, NHORa7, C(0)Rb7, C(0)NRc7Rd7, C(0)NRc7(0Ra7), C(0)0Ra7, 0C(0)Rb7,0C(0)NRc7Rd7, NRc7Rd7, NRc7NRc7Rd7NRc7C(0)Rb7, NRc7C(0)GRa7, NRc7C(G)NRc7Rd7, C(=NRe7)Rb7, C(=NRe7)NRc7Rd7, NRc7C(=NRe7)MRc7Rd7, NRc7C(=NRe7)Rb7, NRc7S(0)Rb7, NRc 7S(0)NRc?Rd?, NRc7S(0)2Rb7, NRc7S(0)(=NRe7)Rb7, NRc7S(0)2NRc7Rd7, S(0)Rb7, S(0)NRc7Rd7, SsOi -R1'. S(0)2NRc7Rd7, 0S(0)(=NRe7)Rb7, 0S(0)2Rb7, SF5, P(0)Rf¾g7, 0P(0)(0Rh7)(0Ri7), P(0)(0Rh7)(0R17), and BR’7Rk7, wherein the Ci-6alkyl CMalkenyl C2-6alkynyl, C&.14aryl, C3-14cycloalkyl, 5-14 membered heieroaryl, 4-14 memberedheterocycloalkyl, Ce-i4 aryl-C -6 alkyl-, Cs-u cycloalkyl-Ci-e alkyl-, (5-14 membered heteroaryl)-C]-6 alkyl-, and (4-14 membered heterocy cloalkyi)-Ci-6 alkyl- of RJare each optionally substituted with 1 , 2, 3, or 4 independently selected R substituents;each Ra / , Rc7, and Rd7is independently selected from H, Ci-6 alkyl Ci-6 haloalkyl C2-6 alkenyl, C2-5alkynyl, C&-14 aryl, C3..14cycloalky 1, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-u aryl-C i-e alkyl-, C3-i4cycloalkyl-C -6alkyl-, (5-14 membered heteroaryl)-Ci-6alkyl-, and (4-14 membered heterocycloalky l)-C 1.6 alkyl- wherein the Ci-e alkyl, C2-6 alkenyl, C2-f,alkynyl Ce-w aryl, C3-Mcycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-u aryl-C -e alkyl-, CS-Mcycloalky l-Ci^ alkyl-, (5-14 membered heteroaryl)-Ci-6alkyl-, and (4-14 membered heterocycloalky 1)-C 1.6 alkyl- of Ra / , Rc', and Rd' are each optionally substituted with 1, 2, 3, or 4 independently selected RKsubstituents; or any R0?and Rd / attached to the same N atom, together with the N atom to which they are attached, form a 5- or 6-membered heteroary l or a 4-14 membered heterocycloalkyl group, wherein the 5- or 6-membered heteroaryl or 4-14 membered heterocycloalkyl group is optionally substituted with 1, 2, 3, or 4 independently selected RKsubstituents;each Rb7is independently selected from H, Cj-6alkyl, Cj-6haloalkyl C2-s alkenyl, C2-6 alkynyl, C&.14aryl, C3-14cycloalkyl, 5-14 membered heieroaryl, 4-14 memberedheterocycloalkyl CMary I-C1-& alkyl-, C3-14cycloalkyl-Ci-e alkyl-, (5-14 membered heteroaryl)-C]-6 alkyl-, and (4-14 membered heterocycloalkyi)-Ci-6 alkyl-, wherein the C -e alkyl, C2-&alkenyl, C2-&alkynyl, Ce-w aryl, C3-14cycloalkyl, 5-14 membered heieroaryl, 4-14 membered heterocycloalkyl, C6-Haryi-C -6alkyl-, Cs-w cycloalkyl-C i-e alkyl-, (5-14 membered heteroaryl)-Ci.6 alkyl-, and (4-14 membered heterocycloalkyl)-C½alkyl- of Rb?are each optionally substituted with 1 , 2, 3, or 4 independently selected R substituents;each R8 / is independently selected from H, OH, CN, Ci-e alky l, C2-6 alkenyl, Ci-e alkoxy, Ci-s haloalkyl, Ci-ghaloalkoxy, C2-6 alkynyl, Ce-w aryl, C3-34 cycloalkyl, 5-14 membered heteroaryl, and 4-14 membered heterocycloalkyl;each Rnand Rg / is independently selected from IT, Ci-g alkyl, CM alkoxy, C haloalkyl, Ci-ghaloalkoxy, C2-6 alkenyl, C2-6 alkynyl, Ca-u aryl, Cg-w eyeloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Cg-14 aryl-Ci-g alkyl-, Cs-u cycloalkyl- Ci-f,alkyl-, (5-14 membered heteroaryl) -C -6alkyl-, and (4-14 membered heterocycioalkyl)-C -6alkyl-;each Rh?and R" is independently selected from H, CM alkyl, CM haloalkyl, C2-6 alkenyl, C2-6 alkynyl, Cg-k aryl,€3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Cg-14 ary 1-C alkyl-, C -i+ cycloalkyl-C -e alkyl-, (5-14 membered heteroaryl)-C]-6 alkyl-, and (4-14 membered heterocycloalkyi)-Ci-6 alkyl-;each Ri7and Rkiis independently selected from OH, C alkoxy, and Ci-ghaloalkoxy; or, any Rj' and Rk / attached to the same B atom, together with the B atom to which they are attached, form a 5- or 6-membered heterocycloalkyl group optionally substituted with 1, 2, 3, or 4 substituents independently selected from C alkyl and CM haloalkyl:each RKis independently selected from H, D, OH, halo, oxo, CN, C(0)0H, NH2,NO2, SFs, C -g alkyl, CM alkoxy, Ci-ghaloalkoxy, C haloalkyl, C2-g alkenyl, C2-g alkynyl, Cg. 1 and, C3.14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Cg-i4aryi-Ci-g alkyl-, CVw cyctoalkyl-C alkyl-, (5-14 membered heteroaryi)-C;i-g alkyl-, and (4-14 membered heterocycloalky 1)-CM alkyl-; andwherein any heteroaryl group of any of the above-recited substituents optionally comprises an N-oxide on any ring-forming nitrogen.

3. The compound of claim 1 or 2, or a pharmaceutically acceptable salt thereof;wherein:each RJis independently selected from D, halo, oxo, Ci-g alkyl, Ci-g haloalkyl, C2-6 alkenyl, CM alkynyl, Cg-i4aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, CM* aiyT-C i-e alkyl-, Cg-Hcycloalkyl-C -g alkyl-, (5- 14 membered heteroaryl)-C i-6 alkyl-, and (4-14 membered heterocyeloalkyl)-tT-s alkyl-, CN, N02, ORa7,each Ra / , Rc', and Rd7is independently selected from H, C i-s alkyl, Ci-s haloalkyl, C2-6 alkenyl, C2-6alkynyl, C&-14 aryl, C3..14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, CM* aryl-C i-e alkyl-, C3-i4 cycloalkyl-Ci-6 alkyl-, (5-14 membered heteroaryi)-Ci-6alkyl-, and (4-14 membered heterocycloalkyi)~C 1-6 alkyl-;or any Rc / and Rd / attached to the same N atom, together with the N atom to which they are attached, form a 5- or 6-membered heteroaryl or a 4-14-membered heterocycloalkyl group; andeach Rb7is independently selected from H, Ci-e alkyl, C2-6 alkenyl, C2-6 alkynyl, CM* aryl C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-u aryl- C [-6alkyl-, C3-i4 cycloalkyl-Ci-6 alkyl-, (5-14 membered heteroaryl)-C 1-6 alkyl-, and (4- 14 membered heterocycloalkylVCi-e alkyl-.

4. The compound of any one of claims 1 -3, or a pharmaceutically acceptable salt thereof; wdrerein:each R1is independently selected from D, halo, oxo, Ci-e alkyl, Ci-e haloalkyl, C2-6 alkenyl, C2-6 alkynyl, Ce-u aryd, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce- aryd-C 1.5 alkyl-, C3-14 cycloalky l-Ci-6 alkyl-, (5-14 memberedheteroaryl)-C 1-6 alkyl-, and (4-14 membered heterocycloalkyd)-C i-s alkyl-, CN, N02, ORa5,each Ra6, Rcf>, and Rdois independently selected from H, Ci-s alkyl, C1-6 haloalkyl, C2-6alkenyl, C2-6 alkynyl, Ce-u aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, CM* ary 1-C [-6 alkyl-, C3-14 cycloalkyl-C]^ alkyl-, (5-14 memberedheteroaryl)-C i-s alkyl-, and (4-14 membered heterocycloalkyd)-Ci-6 alkyl-;or any Rc6and RdRattached to the same N atom, together with the N atom to which they are attached, form a 5- or 6-membered heteroaryl or a 4-14-membered heterocycloalkyl group; andeach Rbois independently selected from H, Ci-e alky l, Ci-e haloalkyl, C2-6 alkenyl, C2-0 alkynyl, Ce-w aryl, C3-Hcycloalkyl, 5-14 membered heteroaiyl, 4-14 memberedheterocyeloalkyl, C6-i4 aryi-Cs-6alkyl-, Cs-w eyeloalkyi-Ci-e alkyl-, (5-14 membered heteroaryl)-Ci.6 alkyl-, and (4-14 membered heterocycioalkyl)-Ci.6 alkyl-.

5. The compound of any one of claims 1-4, or a pharmaceutically acceptable salt thereof, wherein Cy!is CM4 aryl, wherein the Cw4 aryl is optionally substituted with 1, 2, 3, or 4 independently selected RKsubstituents.6 The compound of any one of claims 1-4, or a pharmaceutically acceptable salt thereof, wherein Cy!is Cs-u cycloalkyl, wherein the CT-i Cycloalkyl is optionally substituted with 1, 2, 3, or 4 independently selected Rbsubstituents.

7. The compound of any one of claims 1-4, or a pharmaceutically acceptable salt thereof, wherein Cy1is 5-14 membered heteroary l, wherein the 5-14 membered heteroasyl is optionally substituted with 1, 2, 3, or 4 independently selected Rbsubstituents.

8. The compound of any one of claims 1 -4, or a pharmaceutically acceptable salt thereof, wherein Cy1is 4-14 membered heterocyeloalkyl, wherein the 4-14 membered heterocyeloalkyl is optionally substituted whh 1, 2, 3, or 4 independently selected REsubstituents.

9. The compound of any one of claims 1-4, or a pharmaceutically acceptable salt thereof, wherein Cy!is phenyl or 5-10 membered heteroaryl, wherein the phenyl or 5-10 membered heteroarji is optionally substituted with 1, 2, 3, or 4 independently selected Rbsubstituents.

10. The compound of any one of claims 1 -4, or a pharmaceutically acceptable salt thereof, wherein Cy1is selected from phenyl, pyridinyl, furanyl, benzofuranyl, and pyrazolyl, each of wdiieh is optionally substituted with 1 , 2, or 3 substituents selected from C 1-3 alkyl, halo, CN, and C 1..3 alkoxy.

11. The compound of any one of claims 1-4, or a pharmaceutically acceptable salt thereof, wherein the optionally substituted Cy!is selected from eyanophenyl,cyanofluorophenyl, 2,3-dihydro-l / / ~pyrrolo[2,3,-b]pyridine, phenyl, methoxyphenyi, fluorophenyl, pyridinyl, methyifuranyl, benzofuranyl, and methyl- li / -pyrazoiy 3.

12. The compound of any one of claims 1-4, or a pharmaceutically acceptable salt thereof, wherein the optionally substituted Cy1is selected from 2-cyanophenyl, 3- cyanophenyl, 3-cyano-2 -fluorophenyl, 2,3-dihydro-l / / -pyrrolo|2,3,~b]pyridine, phenyl, 3- metliox phenyl, 2 -fluorophenyl, pyridine-4-yL 2-methy!:furan-3-yL benzofuran-2-yl, and 1- methy!-! / / -pyrazol-4-yi.

13. The compound of any one of claims 1-4, or a pharmaceutically acceptable salt thereof, wherein the optionally substituted Cy!is selected from 3-cy anophenyl and phenyl.

14. The compound of any one of claims 1-13, or a pharmaceutically acceptable salt thereof, wherein Cy2is Ce-u aryl, wherein the CG-Maryl is optionally substituted with 1, 2, 3, or 4 independently selected K" substituents.

15. The compound of any one of claims 1-13, or a pharmaceutically acceptable salt thereof, wherein Cy2is Cs-u cycloalkyl, wTierein the CT-o cycioalkyl is optionally substituted with 1, 2, 3, or 4 independently selected R"substituents.

16. The compound of any one of claims 1-13, or a pharmaceutically acceptable salt thereof, wherein Cy is 5-14 membered heteroaryl, wherein the 5-14 membered heteroaryl is optionally substituted with 1, 2, 3, or 4 independently selected R' substituents.

17. The compound of any one of claims 1 -13, or a pharmaceutically acceptable salt thereof, wherein Cyzis 4-14 membered heterocycloalkyl, wherein the 4-14 membered heterocycloalkyl is optionally substituted with 1, 2, 3, or 4 independently selected Rrsubstituents.

18. The compound of any one of claims 1-13, or a pharmaceutically acceptable salt thereof, wherein Cy2is selected from CT-scycloalkyT, phenyl, 5-10 membered heteroaryl, and 5-10 membered heterocycloalkyl;wherein the 5-10 membered heteroaryi and 5-10 membered heterocycloalkyl each comprise one, two, or three nitrogen atoms as ring-forming heteroatoms, wherein one of theone or two nitrogen atoms is optionally an N-oxide, and wherein a ring-forming carbon atom is optionally substituted by oxo; andwherein the C3-6 cycloalkyl, phenyl, 5-10 memhered heteroaryl, and 5-10 membered heterocycloalkyl are each optionally substituted with 1, 2, or 3 substituents selected from C1..3 alkyl, Ci-3 alkyl-OH, halo, CM,€ alkoxy, and C(0)NH2,19. The compound of any one of claims 1-13, or a pharmaceutically acceptable salt thereof, wherein Cy2is selected from pyridmyl, tetrahydropyridinyl, piperidinyl, pyridine-N- oxide, oxo-dihydropyridinyl, phenyl, pyrazolo[l,5-a]pyridin-3-yl, pyrazolo[l,5-b]pyridazinyl, pyrazolyl, pyrimidinyl, quinolinyl, oxazolyl, 2,3-dihydro-[l ,4]dioxino[2,3-bJpyridin-8-yl, and triazolyl each of which is optionally substituted with 1, 2, or 3 subs ti tuents selected from C1-3 alkyl, Ci-3alkyl-OH, halo, CN, C 1-3 alkoxy, and C(C))NH>;.

20. The compound of any one of claims 1-13, or a pharmaceutically acceptable salt thereof, wherein Cy2is cyclopropyl optionally substituted with 1 , 2, or 3 substituents selected from Ci-3 alkyl, halo, CN, C 1.3 alkoxy, and C(0)NH2.

21. The compound of any one of claims 1 -13, or a pharmaceutically acceptable salt thereof, wherein the optionally substituted Cy2is selected from 2,6-dimethylpyridin-4-yl, pyridin-4-yl, 2~methy!pyridin-4-yl, l-carbamoyl-l,2,3,6-tetrahydropyridin-4-yl, 1- carbamoylpiperidin-4-yl, 2-methoxypyridin-4-yl, 2-methoxy -6-methy lpyridin-4-y 1, 2,6- dimethylpyridin-4-yl-l -oxide, l-ethyl-6-oxo-l ,6-dihydropyridin-3-yl, 3-methylpyridin-4-yl, 3-fluoropyridin-4-yl, 3-chloropyridin-4-yl, 3-methoxypyridin-4-yl, 3-cyanopyridm-4-yl, 4- carbamoy lpheny 1, py razolo [1,5 -a]pyridin-3 -y 1, pyrazolo[ 1 ,5 -b]py ridazin-3 -y 1, 5 -methy 1- 1 H- pyrazol-4-yl, l-ethyl-lH-pyrazol-5-yl, 1 -isopropyl-1 H-pyrazol-5-yl, 1 -propyl-1 H-pyrazol-5- yl, pyrimidin-4-yl, 2,3-dihydro-[l,4]dioxino[2,3-b]pyridin-8-yl, quinolin-5-yl, 5- fluoropyrimidin-4-yl, oxazol-5-yl, 4-methyloxazol-5-yl, 4-ethy!oxazol-5-yl, 4-(hydroxy methy l)-2-methyloxazol-5-yl, 4-(metiioxymethyl)-2 -methy loxazol-5-yl, 4- (hy droxymethy l)-2-methyloxazol-5-yl, 1-ethyl-lH-l ,2,3-triazol-5-yl, and cyclopropyl.

22. The compound of any one of claims 1-21, or a pharmaceutically acceptable salt thereof, wherein R1is selected from H and Ch-s alkyl.

23. The compound of any one of claims 1 -21, or a pharmaceutically acceptable salt thereof, wherein R!is H or Ci-3alkyl.

24. The compound of any one of claims 1-21, or a pharmaceutically acceptable salt thereof, wherein R1is H or ethyl.

25. The compound of any one of claims 1-21, or a pharmaceutically acceptable salt thereof, wherein R1is H.

26. The compound of any one of claims 1-25, or a pharmaceutically acceptable salt thereof, wherein R2is selected from H, Ci-e alkyl, Cs-i+aryl, C3-i4 cycloalky 1, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyi, C6-Maryl-Ci-6alkyl-, C3-14 cycloalky 1-C 1-6 alkyl-, (5-14 membered heteroaryl)-C 1-6 alkyl-, (4-14 membered heterocy cloalkyl)-C 1-6 alkyl-, ORa2, NRC2R··2. C(0)Rb\ C(0)NRc2Rd2, and C(0)GRa2. wherein the Cwalkyl, Ce-uaiyl, C3-14 cycloalkyl, 5-14 membered heteroaryd, 4-14 membered heterocycloalkyi, Ce-u asyl-Ci-6alkyl-, C3 -14 cycloalkyl-Ci4>alky 1-, (5-14 membered heteroaryd)-Ci-6alkyl-, and (4-14 membered heterocy cloalkyl)-C i-b alkyl-, are each optionally substituted with 1, 2, or 3 independently selected R'-substituents.

27. The compound of any one of claims 1-25, or a pharmaceutically acceptable salt thereof, wherein R2is selected from H, Ci-e alkyl, Ce-waryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyi, C6-Maryl-Ci-6alkyl-, C3-i4 cycloalky 1-C 1-6 alkyl-, (5-14 membered heteroaryl)-C 1-6 alkyl-, (4-14 membered heterocy cloalkyl)-C 1-6 alkyl-, ORaz, NRC2R··2. C(0)Rb2, C(0)NRc2Rd2, and C(0)0Ra2. wherein the Cwalkyl, Ce-uaiyl, C3-14 cycloalkyl, 5-14 membered heteroaryd, 4-14 membered heterocycloalkyi, Ce-u asyl-Ci-6alkyl-, C3.14 cy cloalky 1-C 1-6 alkyl-, (5-14 membered heteroaryl)-Ci.-6 alkyl-, and (4-14 membered heterocy c!oalky!)-Ch-6alkyl-, are each substituted with 1, 2, or 3 independently selected Rcsubstituents.

28. The compound of any one of claims 1-25, or a pharmaceutically acceptable salt thereof, wherein R2is selected from H, phenyl, 5-6 membered heteroaryd, C(0)Rbi,C(0)NRc2Ra2, and C(0)0Ra2, wherein the phenyl and 5-6 membered heteroaryd are each optionally substituted with 1 or 2 independently selected RLsubstituents.

29. The compound of any one of claims 1 -25, or a pharmaceutically acceptable salt thereof, wherein R2is selected from H, C(0)0Ft, CONH , and C(0)NHEt.

30. The compound of any one of claims 1-25, or a pharmaceutically acceptable salt thereof, wherein R2selected from phenyl and 5-6 membered heteroaryl, each of which is optionally substituted with C(0)0Me.

31. The compound of any one of claims 1 -25, or a pharmaceutically acceptable saltthereof, wherein32. The compound of any one of claims 1-25, or a pharmaceutically acceptable salt thereof, wherein the optionally substituted R2is selected from pyridinylmethyl,hydroxy (phenyl)methyl, hydroxyethylamino(phenyl)ethyl, eyclohexyhnethyl, fluorobenzyl, hydroxy(fluorophenyl)methyl, (methylpyridinyl)methyl, (fluoropyridinyl)methyl,(triiluoroinethylpyridinyl)methyl, ((hydroxymethyl)pyridinyl)methyl,(meihoxypyridinyi)methyl, (methylpyrazolyl)benzyl, (methylpyrazolyl)methyl,benzoisoxazolylmethyl, (methylindazolyl)methyl, (hydroxyazetidinyl)methyl, benzoyl, phenylcyclopropyl, (cyano(phenyl)methyl)amino, tetrahydrofuranyl,phenyl(pyridinyloxy)methyl, fluoro ((fluorohydroxypyrrolidinyl)methyl)benzyl,((carboxy piperidiny Ijmethy l)fluorobenzy 1, fluoro((N - methyhnethylsulfonamido)methyl)benz>d, ((dioxoimidazolidinyl)methyl)fluorobenzjT, (difluorophenyi)(hydroxy)methyl, (pyridinyi-lH-tetrazolyl)methyl, (pyrazolyl-lH- tetrazolyl)methyl, (thiazoiyl-lH-teirazoly3)methyl, (methyltrifluoromethylpyrazoiyl)methyl, ((l,l~dioxidoisothiazolidinyl)methyi)fluorobenzyl, ((methyl -2,5- dioxoiinidazolidinyl)methyi)benzyl, and (cyanophenoxy)methyl.

33. The compound of any one of claims 1-25, or a pharmaceutically acceptable salt thereof, wherein the optionally substituted R2is selected from pyridin-2-ylmethyl, hydroxy (phenyl)methyl, (2-hydroxy ethylamino)(phenyl)methyl, eyclohexyhnethyl, 2- fluorobenzyl, (2-fluorophenyl)(hydroxy)methyl, (6-methylpyridin-2-yl)methyl, (3- fluoropyridin-2-yl)methyl, (3-methoxypyridin-2-yl)methyl, 2-(l~methyl-lH-pyrazol~4- yl)benzyi, benzo[d]isoxazol-3-yhnethyl, (l-metiiyl-lH-indazol-3-yl)methyl, (3-hydroxyazetidin-l-yl)methyl, benzoyl, 1 -phenylcyclopropyl, (cyano(phenyl)methyl)amino, tetrahydrofuran-3-yl, phenyl(pyridin-2-yloxy)methyl, 2-fluoro-6-(((3R,4R)-3-fluoro-4- hydroxypyrrolidin-l -yl)methyl)benzyl, 2-((4-carboxypiperidin-l-yl)methyl)-6-fluorobenzyl, 2-fluoro-6-((N-methylmethylsulfonamido)methyl)benzyl, 2-((2,5-dioxoimidazolidin-l- yi)methyl)-6-fluorobenzyl, (2,6-difluorophenyl)(hydroxy)methyl, (5-(pyridin-2~yi)-lH~ tetrazol-l-yl)methyi, (5-(lH-pyrazol-l-yl)-lH-tetrazol-l-yl)methyl, (5-(thiazol-4-yl)-lH- tetrazol-l-yl)methyl, (5-methyl-3-(trifluoromethyl)-lH-pyrazol-l -yl)methyl, (3- methyipyridm-2-yi)methyi, 2-((l,l-dioxidoisothiazolidin-2-yl)methyl)-6-fluorobenzy'l, 2- fluoro-6-((3 -methyl-2, 5-dioxoimidazolidin- 1 -y l)methy l)benzy 1, (6-(trilluoromethy l)pyridin-2- yl)methyl, (3-(hydroxymethyl)pyridin-2-yl)methyl, (l-methyl-lH-pyrazol-3-yl)methyl, and (2-cyanophenoxy)metliyl, (3-methylpyridin-2-yl)methoxy, (6-methylpyridin-2-yl)methoxy, and ((3 -methy Spy ridin-2-yf)methy 3)amino .

34. The compound of any one of claims 1-28, or a pharmaceutically acceptable salt thereof, wherein each Rcis independently selected from halo, Ci-6alkyl, C&-Karyl, 5-14 membered heteroaryl, (4-14 membered heterocycloalky l)-Ci-6 alkyl-, OR34, C(0)0Ra4, and NRc4Rd4, wherein the Ci-f,alkyl, 5-14 membered heteroary l, and (4-14 membered heterocycloalky l)-Ci-6alkyl- are optionally substituted with 1, 2, or 3 independently selected Rrisubstituents.

35. The compound of any one of claims 1-28 and 34, or a pharmaceutically acceptable salt thereof, wherein each Rhis independenty selected from halo, oxo, Cw, alkyl, Cw, haloalkyl, OR35, C(0)0R35, and NRc5S(0)2Rb5.

36. The compound of any one of claims 1 and 3-35, or a pharmaceutically acceptable salt thereof, wherein R3is selected from H, halo, Ci-b alkyl, Cs-u aryl, 5-14 membered heteroaryl, CN, and ORa3, wherein the GT-g alkyl, Ce-waryl, and 5-14 membered heteroary l are each optionally substituted with 1 , 2, or 3 independently selected RiJsubstituents.

37. The compound of any one of claims 1 and 3-35, or a pharmaceutically acceptable salt thereof, wherein R3is selected from H, C1-3 alkyl, halo, CN, morpholinomethyl, 4- ethoxyphenyl, 2-hydroxyethoxy, and pyridinyl.

38. The compound of any one of claims I and 3-35, or a pharmaceutically acceptable salt thereof, wherein R3is selected from H, methyl, bromo, CN, morpholinomethyl, 4- ethoxyphenyl, 2-hydroxyethoxy, and pyridinyl39. The compound of claim 1, or a pharmaceutically acceptable salt thereof; wherein:R!is selected from H and C--6alky l;R2is selected from H, D, Cf,-]4 aryl, 5-14 membered heteroaryl, C(0)Rb2,C(0)NRc2Ra2, and C(Q)ORa2, wherein the Cs-uaryi and 5-14 membered heteroaryl of R2are each optionally substituted with 1, 2, 3, or 4 independently selected Rcsubstituents;R3is selected from H, D, halo, Ci-6alkyl, Ci-&haloalkyi, Ce-i+aryl, 5-14 membered heteroaryl, CN, and OR33, wherein the CMalkyl, Ce-waryl, and 5-14 membered heteroary l of R3are each optionally substituted with 1, 2, 3, or 4 independently selected RDsubstituents;Cy!is phenyl optionally substituted with 1, 2, 3, or 4 independently selected RMsubstituents, or CIO-Maryl or 5-14 membered heteroaryl, wherein the CIO-Maryl and5-14 membered heteroaryl of Cy!is optionally substituted with 1, 2, 3, or 4 independently selected R substitxtents;Cy2is Cf,- 4 aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl or 4-14 membered heterocycloalkyl, wherein the Cg-i aryl, CS-Hcycloalkyl, 5-14 membered heteroaryl and 4-14 membered heterocycloalkyl of Cy2are each optionally substituted with 1, 2, 3, or 4 independently selected Rbsubstituents;each R32, RC2, Rd2, and R33is independently selected from H, Ci-&alkyl, Ci.&haloalkyi, C2-6 alkenyl, C2-6alkynyl, Cf,- 4 aryl, C3-14cycloalkyl, 5-14 membered heteroaryl, and 4-14 membered heterocycloalkyl, wherein the CMalkyl, C2-6 alkenyl, C2-6 alkynyl, Ce-uatyl, C3-14 cycloalkyl, 5-14 membered heteroar l, and 4-14 membered heterocycloalky 1 of R32, Rci, Rd2, and R33are each optionally substituted with 1, 2, 3, or 4 independently selected RGsubstituents;each Rb2is independently selected from Cue alkyl, Ci-e haloalkyi, C2-6 alkenyl, C2-6alkynyl, Ce-u aryl, C3-Mcycloalkyl, 5-14 membered heteroaryl, and 4-14 membered heterocycloalkyl, wherein the C -6alkyl, C2-6 alkenyl, C2-6 alkynyl, Ce-w arvd, C3-14cycloalkyl, 5-14 membered heteroaryl, and 4-14 membered heterocycloalkyl are each optionally substituted with 1, 2, 3, or 4 independently selected RGsubstituents;each Rc, KD, RE, Rr, and RGis independently selected from D, halo, oxo, CM alkyl, Ci-6haloalkyi, C2-6alkenyl, C2-6alkynyl, Cg-i aryl, C3-14cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, CN, NO2, OR34, SR34, NHOR34, C(0)RM,NRC4S(0)2Rm, and NRc4S(0)2NRc4Rd4, wherein the C -6 alkyl, C2-6 alkenyl, C2-6 alkynyl, CM4aryl, Cs-ir cycloalkyl, 5-14 membered heteroaryl, and 4-14 membered heterocycloalk l of Rc, RD, RE, RF, and Ruare each optionally substituted with 1 , 2, 3, or 4 independently selected RHsubstituents;each RMis independently selected from D, halo, oxo, Cw, alkyl, Cw, haloalkyl, C2-6 alkenyl, C2-6 alkynyl, Ce-i+aiyl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, 2-CN, 3-CN. NO2, OR34, SRa4, NHORa4, C(0)RM, C(0)NRc4Rd4, C(G)ORa4, 0C(0)Rm, 0C(0)NRc4Rd4, NRc4Rd4, NRc4C(0)RM, NRcC(0)0Ra4, NRc4C(0)NRc4Rd4, C(=NRe4)Rb4, C(=NRe4)NRc4Rd4, NRc4C(=NRe4)NRo4Rd4, NRc4S(0)Rb4, NRc4S(0)2RM, and NRc4S(0)2NRc4Rd4, wherein the Cue alkyl, C2-6alkenyl, C2-e alkynyl, Cc-+aryl, C3-14cycloalky l, 5-14 membered heteroaryl, and 4-14 membered heterocycloalkyl of RMare each optionally substituted with 1, 2, 3, or 4 independently selected Rrisubstituents;each R3+, Rc4, and Rd4is independently selected from H, C -6alkyl, C -6haloalkyl, C2-6alkenyl, C2-6alkynyl, Ce-ir aryl, C3-14cycloalkyl, 5-14 membered heteroaryl, and 4-14 membered heterocycloalkyl, wherein the Ci-6alkyl, C2-6 alkenyl, C2-6 alkynyl, C6-i4ai l, C3-Wcycloalkyl, 5-14 membered heteroaryl, and 4-14 membered heterocycloalkyl of Ra4, Rc4, and Rd4are each optionally substituted with 1, 2, 3, or 4 independently selected Rrisubstituents; each Rfc4is independently selected from CM;alkyl, Ci-e haloalkyl, C2-6alkenyl, C2-6alkynyl, C&-14aryl,€3-14cycloalky 1, 5-14 membered heteroaryl, and 4-14 membered heterocycloalkyl, wherein the C -6 alkyl, C2-6alkenyl, C2-6 alkynyl, Ce-ir aryl, C3-14eycloalkyl, 5-14 membered heteroaryl, and 4-14 membered heterocycloalkyl are each optionally substituted with 1, 2, 3, or 4 independently selected Rhsubstituents;each R84is independently selected from H, OH, CN, Cj-6alkyl, Ci-ealkoxy, Cw haloalkyl, and Ci-ehaloalkoxy;each RHis independently selected from D, halo, oxo, C1-6 alkyl, C1-6 haloalkyl, C2-6alkenyl, C2-6alkynyl, Ce-u aryd, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, CN, NQ2, OR35, SRC NHORa5, C(0)Rb5, C(0)NRc5Rd5, C(0)0Ra5,NRc''S(0)2NRc''Rd, wherein the Cw alkyl, C2-e alkenyl, C2-e alkynyl, Ce-i4 aryl, C3-14 cycloalky l, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, of Rflare each optionally substituted with 1, 2, 3, or 4 independently selected R!substituents;each R35, Rc5, and Rd>is independently selected from H, Ci-e alkyl, Ci-e haloalkyl, C2-6 alkenyl, C2-6 alkynyl, Ce-w aryl, C -u cycloalkyl, 5-14 membered heteroaryl, and 4-14 membered heterocycloalkyl, wherein the C i-s alkyl, C2-6 alkenyl, C2-6 alkynyl, Cs-n aryl, C3-w cycloalkyl, 5-14 membered heteroaryl, and 4-14 membered heterocycloalkyl of R34, Rc4, and Rd4are each optionally substituted with 1, 2, 3, or 4 independently selected R!substituents; each Rb5is independently selected from Ci-e alkyl, Ci-e haloalky 1, C2-6 alkenyl, C2-6 alkynyl, Ci.-w aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, and 4-14 membered heterocycloalkyl, -wherein the Cj-e alkyl, C2-6 alkenyl, C2-6 alkynyl, C b-u aryl, C3.14 cycloalkyl, 5-14 membered heteroaryl, and 4-14 membered heterocycloalkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R1substituents;each R85is independently selected from H, OH, CN, Ci-e alkyl, Ci-e alkoxy, Ci-e haloalky!, and Ci-ehaloalkoxy;each R1is independently selected from D, halo, oxo, Ci-e alkyl, Cue haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C&-14 aryl, C3..14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, CN, N02, OR36, SR*6, NHOR*6, C(0)Rbf>, C(0)NRc6Rd6, C(0)0Raf>, 0C(0)Rb6, 0C(0)NRc6Rd6, NRc6Rd6, NRc6C(0)Rb6, NRc6C(0)0R36, NRc6C(G)NRc6Rd6, C(=NRe6)Rb6, C(=NRe6)NRc6Rd6, NRc6C(=NRe6)NRc6Rd6, NRc6S(0)Rb6, NRc6S(0)3Rb6, and NRc6S(0)2NRc6Rd6, wherein the Ci-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, Ce-14 aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, of Rhare each optionally substituted with 1, 2, 3, or 4 independently selected RJsubstituents;each Ra6, Rcf>, and Rd6is independently selected from H, Ci-6alkyl, Ci-6haloalkyl, C2-6 alkenyl, C2-6 alkynyl, Ce-w aryl, C3- cycloalkyl, 5-14 membered heteroaryl, and 4-14 membered heterocycloalkyl, wherein the Ci-6alkyl, C2-6 alkenyl, C2-6 alkynyl, Cg-w aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, and 4-14 membered heterocycloalkyl of R36, RCR, and Rd6are each optionally substituted with 1, 2, 3, or 4 independently selected RJsubstituents; each Rb6is independently selected from Ci-b alkyl, Ci^ haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C&-J4 aryl, Cs-w cycloalky 1, 5-14 membered heteroaryl, and 4-14 membered heterocycloalkyl, wdierein the Cj-e alkyl, C2-6 alkenyl, C2-6 alkynyl, C b-u aryl, C3-w cycloalkyl, 5-14 membered heteroaryl, and 4-14 membered heterocycloalkyl are each optionally substituted with 1, 2, 3, or 4 independently selected RJsubstituents;each Re6is independently selected from H, OH, CN, C .-s alkyl, C .-s alkoxy, Ci-6haloalkyl, and C i-ehaloalkoxy;each R3is independently selected from D, halo, oxo, C]_6alkyl, Cj-e haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C&-J4 aryl, C3- cycloalkyl, 5-14 membered heteroaryl, 4-14 memberedheterocycloalkyl, CN, N02, OR37, SR37, NHOR37, C(0)Rb7, C(0)NRc7Rd7, C(0)0Ra7,NRC / S(0)2NRC / Rd / , wherein the Ci-6 alkyl, C2.6 alkenyl, C2.6 alkynyl,€5-14 aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, of RHare each optionally substituted with 1, 2, 3, or 4 independently selected RKsubstituents;each Ra / , Re', and Rd' is independently selected from H, Ci-6alkyl, Ci-6haloalkyl, C2-6 alkenyl, C2-6 a!kynyl, Ce-i+aiyl, C3-14 cycloalkyl, 5-14 membered heteroaiyi, and 4-14 membered heterocycloalkyl, wherein the Ci.&alkyl, C2-6 alkenyl, C2-6 alk nyl, CCi+aryl, C3-14 cycloalkyl, 5-14 membered heteroaiyi, and 4-14 membered heterocycloalkyl of Ra / , Rc7, and Rd' are each optionally substituted with 1, 2, 3, or 4 independently selected RKsubstituents; each Rb' is independently selected from Ci-e alkyl, Ci-e haloalkyl, C2-6 alkenyl, C2-6 alkynyl, Ce-u aryl, Cs-ir cycloalkyi, 5-14 membered heteroaiyi, and 4-14 membered heterocycloalkyl, wherein the Ci-e alkyl, C2-6 alkenyl, C2-6 alkynyl, Gs-14 aryl, Csu+c cloalkyl, 5-14 membered heteroary l, and 4-14 membered heterocycloalkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R substituents;each Re7is independently selected from H, OH, CN, Ci-e alkyl, Ci-s alkoxy, Ci-&haloalkyl, and Ci-shaloalkoxy;each RKis independently selected from H, D, OH, halo, oxo, CN, C(0)0H, NH2, NO2, SF5, C i -6alkyl, Ci-e alkoxy, C -ehaloalkoxy, Cb-s haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C&.14 aryl, C3-14 cycloalkyl, 5-14 membered heteroaiyi, 4-14 membered heterocycloalkyl; and wherein any heteroaryl group of any of the above-recited substituents optionally comprises an N-oxide on any ring-forming nitrogen.

40. The compound of claim 1, or a pharmaceutically acceptable salt thereof; wherein:R!is selected from H and Ci-6alkyl;R2is selected from H, D, Cf,-i4 ryl, 5-14 membered heteroaryl, C(0)Rb2,C(0)NRc2Ra2, and C(Q)ORa2, wherein the Ce-uaxyl and 5-14 membered heteroaiyi of Rzare each optionally substituted with 1, 2, 3, or 4 independently selected Rcsubstituents;R3is selected from H, D, halo, C]-6alkyl, Ce-u aryl, 5-14 membered heteroaryl, CN, and OR33, wherein the Ci-e alkyl, Ce-i+ar l, and 5-14 membered heteroaryl of R3are each optionally substituted with 1 , 2, 3, or 4 independently selected KDsubstituents;Cy1is phenyl optionally substituted with 1, 2, 3, or 4 independently selected RMsubstituents, or C 10-14 aryl or 5-14 membered heteroaryl, wherein the Cio-14aryl and 5-14membered heteroaryl of Cy1is optionally substituted with 1, 2, 3, or 4 independently selected R substituents;Cy2is Ce-u aryl, CB-Mcycloalkyl, 5-14 membered heteroaryl or 4-14 membered heterocycloalkyl, wherein the Ce-u aryi, C3-14 cycloalkyl, 5-14 membered heteroaryl and 4-14 membered heterocycloalkyl of Cy2are each optionally substituted with 1 , 2, 3, or 4 independently selected Rbsubstituents;each R32, R“, Rdi, and Ra3is independently selected from H, Ci-6alkyl, C2-6 alkenyl, C2-6 alkynyl, Ce-n aryl, C3-14 cycloalkyl, 5-14 membered heteroaryl, and 4-14 membered heterocycloalkyl, wherein the Ci-e alkyl, C2-6alkenyl, C2-6 alkynyl, Ce-w ar l, C3-14cycloalkyl, 5-14 membered heteroaryl, and 4-14 membered heterocycloalkyl of R32, Rc2, Rd2, and R33are each optionally substituted with 1, 2, 3, or 4 independently selected R substituents;each Rb2is independently selected from Ci-&alkyl, C2-6 alkenyl, C2-6alkynyl, Ce-n ary l, C3-] 4 cycloalkyl, 5-14 membered heteroaryl, and 4-14 membered heterocycloalkyl, wherein the Ci-6 alkyl, C2-6 alkenyl, C2-6alkynyl, C&.14aryl, C3.14 cycloalkyl, 5-14 membered heteroaryl, and 4-14 membered heterocycloalkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R° substituents;each Rc, RD, RE, Rr, and R° is independently selected from D, halo, oxo, Ci-f,alkyl, C2-6 alkenyl C2-6 alkynyl, Ce-u aiyl, CB-Hcycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, CN. N02, OR84, SR34, NHORa4, C(0)RM, C(0)NRc4Rd4,NRc4S(0)2.Rb4, and NRc4S(0)2NRc4Rd4, wherein the C1-6alkyl, C2-6alkenyl, C2-6alkynyl, Ce-w ary l, C3-]4 cycloalkyl, 5-14 membered heteroar d, and 4-14 membered heterocycloalkyl of Rc, R4', Re, R", and R° are each optionally substituted wifli 1, 2, 3, or 4 independently selected Rrisubstituents;each RMis independently selected from D, halo, oxo, Ci-6alkyl, C2.6 alkenyl, C2.6 alkynyl, Cw4aiyl, C3-Wcycloalkyl, 5-14 membered here roaryd, 4-14 memberedheterocycloalkyl, 2-CN, 3-CN, NO2, OR34, SR34, NHOR34, C(0)RM, C(0)NRc4Rd4, C(0)0R34,NRc4S(0)2NRc4Rd4, wherein the Ci-6alkyl, C2-6alkenyl, C2-6alkynyl,€5-14 aryl,€3-14 cycloalkyl, 5-14 membered heteroaryl, and 4-14 membered heterocycloalkyl of RMare each optionally substituted with 1, 2, 3, or 4 independently selected RHsubstituents;each Ra+, Rc4, and Rd4is independently selected from H, C -6alkyl, C2-6alkenyl, C2-6 alkynyl, Ce-i+aryl, C3-14cycloalkyl, 5-14 membered heteroaryl, and 4-14 membered heterocycloalkyl, wherein the Ci-b alkyl, C2-6 alkenyl, C2-6 alkynyl, Ce-i+aiyl, Cs-w cycloalky 1, 5-14 membered heteroaryl, and 4-14 membered heterocycloalkyl of R34, Rc4, and Rd4are each optionally substituted with 1 , 2, 3, or 4 independently selected RHsubstituents;each RMis independently selected from C1-6 alkyl€2-6 alkenyl, C2-6 alkynyl, CS-JIaryl, C3-! 4 cycloalky 1, 5-14 membered heteroaryl, and 4-14 membered heterocycloaikyi, wherein the C -e alkyl, C2-6 alkenyl, C2-6 alky nyl, Ce-u and,€3-5+cycloalkyl, 5-14 membered heteroaryl, and 4-14 membered heterocycloaikyi are each optionally substituted with 1, 2, 3, or 4 independently selected RHsubstituents;each R84is independently selected from H, OH, CN, Ci-e alkyl, Ci-e alkoxy, Ci-e haloalkyl, and Ci-ehaloalkoxy;each RHis independently selected from D, halo, oxo, Ci-e alkyl, CN, NO2, OR35, SRa',each Ra5, Rc, and Rd5is independently selected from H, and Cw, alkyl;each Rh5is independently selected from Ci-e alkyl, C2-e alkenyl, C2-6 alkynyl, Ce-14 aryl, C3-14cycloalkyl, 5-14 membered heteroaryl, and 4-14 membered heterocycloaikyi; and each Re5is independently selected from H and C -6alkyl.

41. The compound of claim 2, or a pharmaceutically acceptable salt thereof;wherein:RJis selected from H, Ci-b alkyl, and a 5-14 membered heteroaryl, wherein the Ci-e alkyl and a 5-14 membered heteroaryl are each optionally substituted with 1, 2, or 3 independently selected RBsubstituents;R2is selected from H, D, C -6alkyl, Cf.-+aryl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, Ce-u aryl-Ci-e alkyl-, (5-14 membered heteroaryi)-Ci-6alkyl-, (4- 14 membered heterocycloalky 1)-C]^ alkyl-, NRc2Rd2,C(0)Rb2, C(0) Rc-Raf and C(0)QR32, -wherein the Ci-e alkyl, Ce-w aiyl, 5-14 membered heteroaryl, 4-14 memberedheterocycloalkyl, Ce-w ary l-Ci-6alkyl-, (5-14 membered heteroaryl) -Ci-6alkyl-, (4-14 membered heterocycloalkyl)-Ci-6alkyl- of R2are each optionally substituted with 1, 2, 3, or 4 independently selected Rcsubstituents;Cy!is phenyl, optionally substituted with 1, 2, 3, or 4 independently selected RMsubstituents, or Clo-u aryl or 5-14 membered heteroaryl, wherein the C IO-M aryl and 5-14 membered heteroaryl of Cy!is optionally substituted with 1 , 2, 3, or 4 independently selected Rbsubstituents;Cy2is CVw aryl,€3-14 cycloalkyl, 5-14 membered heteroaryl or 4-14 membered heterocycloalkyl, wherein the Ce-w axyl, C3-Hcycloalkyl, 5-14 membered heteroaryl and 4-14 membered heterocycloalkyl of Cyzare each optionally substituted with 1, 2, 3, or 4 independently selected R!‘substituents;each R3Z, Rc2, and Rd2is independently selected from H, Ci-&alkyl, C2-6 alkenyl, C2-6 alkynyl, Cs-u aryl, Ce-i4aryl-Ci-6 alkyl-, Cs-wcycloalkyl, 5-14 membered heteroaryl, and 4-14 membered heterocycloalkyl, wherein the Cj-6alkyl, C2-6 alkenyl, C2-6 alkynyl, Cs-u aryi, C e-u aryl-Ci-6 alkyl-, C3-Mcycloalkyl, 5- 14 membered heteroaryl, and 4- 14 memberedheterocycloalkyl of Ra2, Rc2, and R32are each optionally substituted with 1, 2, 3, or 4 independently selected R° substituents;each Rb2is independently selected from Cj-6alkyl, C2-6 alkenyl, C2-6 alkynyl, Ce-w aryl, C3 -14 cycloalkyl, 5-14 membered heteroaryl, and 4-14 membered heterocycloalkyl, wherein the Ci-e alkyl, C2-6 alkenyl, C2-6 alkynyl, CC-M aryl, C3- 14 cycloalkyl, 5-14 membered heteroaryl, and 4-14 membered heterocycloalkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R° substituents;each Rb, Rl, Rk, R*, and RGis independently selected from D, halo, oxo, C1 -6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C&.i4aryl, C3-1+ cycloalkyl, 5-14 membered heteroaryl, 4-14 membered heterocycloalkyl, CN, N02, OR84, SRah NHOR34, C(0)RM, C(0)NRc4Rd4,NRC+S(0)2Rm, and NRc4S(0)2NRc+Rd4, wherein the Cj-6alkyl, C2-6 alkenyl, C2-6 alkynyl, C6-w aryl, C3 -14 cycloalkyl, 5-14 membered heteroaryl, and 4-14 membered heterocycloalkyl of RB, R4, Rr. R" , and R° are each optionally substituted with 1, 2, 3, or 4 independently selected RHsubstituents;each RMis independently selected from D, halo, oxo, Ci-f,alkyl, C2-6 alkenyl, C2.-6 alkynyl, Ce-u aryl, Ch-w cycloalkyd, 5-14 membered heteroaryd, 4-14 memberedheterocycloalkyl, 2-CN, 3-CN, NO2, ORa4, SRa4, NHOR84, C(0)RM, C(G)NRc4Rd4, C(0)0Ra4, 0C(0)Rm, 0C(0)NRc4Rd4, NRc4R34, NRC4C(0)R'd4, NRc+C(0)0Ra4, NRc4C(0)NRc4Rd4, C(=NRe4)Rb4, C(=NRe4)NRc4Rd4, Rc4C(-NRe4)NRc4Rd4, NRc4S(0)Rw, NRc4S(0)2Rb4, and NRc4S(0)2NRc4Rd4, wherein the Ci^, alkyl, C2-6 alkenyl, C2.-6 alkynyl, Ce-u aryl, CJ-Mcycloalkyl, 5-14 membered heteroaryl, and 4-14 membered heterocycloalkyl of RMare each optionally substituted with 1, 2, 3, or 4 independently selected RHsubstituents;each Ra, Rc+, and Rd4is independently selected from H, C i-s alkyl, C>;-s alkenyl, C s alkynyl, Ce-u aiyl, C3-14 cycloalkyl, 5-14 membered heteroaryl, and 4-14 membered heterocycloalkyl, wherein the C -6alkyl, C2-6 alkenyl, C2-6 alkynyl, Gs-s+aryi, C3-14 cycloalkyl, 5-14 membered heteroaryl, and 4-14 membered heterocycloalkyl of Ra4, Rc4, and Rd4are each optionally substituted with 1, 2, 3, or 4 independently selected Rrisubstituents;each RMis independently selected from Ci-e alkyl, C2-6 alkenyl, C2-6 alkynyl, Ce-14 aryl, C3 -14 cycloalkyl, 5-14 membered heteroaryl, and 4-14 membered heterocycloalkyl, wherein the Cne alkyl, C2-6 alkenyl, C2-6 alkynyl,€5-14 a yl, C?,-u cycloalky l, 5-14 membered heteroaryl, and 4-14 membered heterocycloalkyl are each optionally substituted with I, 2, 3, or 4 independently selected RHsubstituents;each Re4is independently selected from H, OH, CN, Ci-e alkyl, Ci^ alkoxy, Ci-e haloalkyl, and Ci-shaloalkoxy ;each RHis independently selected from D, halo, oxo. Cue alkyl, CN, NO2, ORa5, SR85,each R3, Rc5, and Rd5is independently selected from H, and Ci-6alkyl;each Rb5is independently selected frotn Cw alkyl, C2-6 alkenyl, C2-6 alkynyl, CM4 aryl, C3U4 cycloalkyl, 5-14 membered heteroaryl, and 4-14 membered heterocycloalkyl; and each R5is independently selected from H and C1-6 alkyl.

42. The compound of claim 1, selected from:3-(5-Amino-8-(2,6-dimethylpyridin-4-yl)iinidazo[l,2-c]pyrimidin-7-yl)benzomtrile;7-(2,3-Dihydro-l / / -pyrrolo[2,3- / >]pyridin-5-yl)-8-(2,6-dimethylpyridin-4- yl)imidazo[l,2-c]pyrimidin-5-amine;8-(2,6-Dimethylpyridin-4-yl)-3-(morpholinomethyl)-7-phenylimidazo[l,2- c]pyrimidin-5-amine;7-(3-Methoxyphenyl)-8-(pyridin-4-yl)imidazo[l ,2-c]pyrimidin-5-amine;7,8-Di(pyridin-4-yl)imidazo[l,2-c]pyrimidin-5-amine;7-(2-Methylfuran-3-yl)-8-(pyridin-4-yl)imidazo| l ,2-c]pyrimidin-5-amine;7-(2-Fluorophenyl)-8-(pyridin-4-yl)imidazo[l,2-c]pyrimidm-5-ainine;7-(Benzofuran-2-yl)-8-(pyridin-4-yl)itnidazo[l,2-c]pyrimidin-5-amine;7-(l-Methyl-] / / -pyrazol-4-yl)-8-(2-methylpyridin-4-yl)imidazo[l,2-c]pyrimidin-5- amine;8-(2-Methylpyridm-4-yl)-2,7-diphenylimidazo| l ,2-c]pyrimidin-5-amine;Ethyl 5-amino-8-(2-methylpyridin-4-yl)-7-phenylimidazo[L2-c]pyrimidine-2- earboxylate;Methyl 5-(5-amino-7-phenyl-8-(pyridin-4-yl)imidazo[l,2-c]pyrimidin-2-yl)isoxazole-3-carboxylate;3-(4-Ethoxyp]ienyl)-8-(2-methyipyridin-4-yl)-7-phenylimidazo[l,2-;,jpyrimidin-5- amine;5~Amino-8-(2-methylpyridin-4-yi)-7-phenylimidazo[ l,2~c]pyrimidine-2~ carboxamide;5-Amino-8-(l-carbamoyl-l,2,3,6-tetraliydropyridin-4-yl)-N-ethyl-7- phenylimidazo[l,2-c]pyrimidine-2-carboxamide;5 -Amino-8-(l -carbamoy lpiperidin-4-y i)- / V-ethy 1-7-pheny limidazo[ 1 ,2-c jpyrimidine- 2-carboxamide;5-Amino-7-(3-cyanophenyl)- / V-elhyl-3-(2-hydroxyethoxy)-8-(2-methoxypyridin-4- yl)imidazo[l,2-c]pyrimidine-2 -carboxamide;5-Ammo-7-(3-cyanophenyl)-Ar-ethyl-8-(2-metiioxypyridin-4-yl)-3- methylimidazo[l,2-i;]pyrimidine-2 -carboxamide;5~Amino-7-(3-cyanoplienyl)-Ai-ethyl-8-(2-methoxypyridin-4-yl)~3-(pyridin-2~ y l)imidazo [ L2-c]pyrimidine-2 -carboxamide;5-Amino-3-bromo-8-(2,6-dimethylpyridin-4-yl)-N-etbyl-7-phenylimidazo[l,2- c]pyrimidine-2 -carboxamide;5-Amino-3-cyano-8-(2,6-dimethylpyridin-4-yl)-lV-ethyl-7-phenylimidazo[l,2- c]pyrimidine-2 -carboxamide;8-(2,6-Dimethylpyridin-4-yl)- / V-ethyl-5-(ethylamino)-7-phenylimidazo[l,2- cjpyrimidine-2 -carboxamide;4-(5-Amino-2-(ethylcarbamoyl)-7-phenylimidazo[l,2-c,]pyrimidin-8-yl)-2,6- dimethylpyridine 1 -oxide;3-(5-Ammo-8-(l-ethyl-6-oxo-l,6-dihydropyridin-3-yl)-2-(3-hydroxyazetidme-l- carbony l)imidazo [ 1 ,2-c]py rimidin-7-y l)benzonitriie;5-Amino-7-(3-cyanophenyl)-8-(l-ethyl-6-oxo-l,6-dihydropyridin-3-yl)- / V-(l -(2- hydroxyethyl)-l / / -pyrazol-4-yl)imidazo[l,2-c]pyrimidine-2-carboxamide;5-Amino-7-(3-cyanophenyl)-Ar-ethyl-8-(pyridin-4-yl)iinidazofl,2-c]pyrimidine-2- carboxamide;5-Amino-7-(3-cyanophenyl)-Af-ethyl-8-(3-methylpyridin-4-yl)imidazo[l,2- c]pyrimidine-2 -carboxamide;5-Amino-7-(3~ey anopheny it-A-eiShyi-H-n-fiuorapyridin- -yi^midazol 1 ,2- e]pyrimidine-2 -carboxamide;5-AmmO 7-(3-cyasiophenyI) V-ethyl 8-(3-chloropyridin-4-yi)imidazo[I ,2- cjpyrimidine-2 -carboxamide;5-Amino-7-(3-cy anopheny l)- / V-ethyl-8-(3-methoxypyridin-4-yl)imidazo[l, 2- cJpyrimidine-2 -carboxamide;5-Amim 7-(3-cyanopheny{)~V-ethy!~8-(3-cyaiiopyridin~4-yl)imidazo[l,2~ c]pyrimidine-2 -carboxamide;5-Amino-8-(4-carbamoylphenyl)-7-(3-cy anopheny l)-N-etiiylimidazo[l, 2- c]pyrimidine-2-carboxamide;5-Amino-7-(3-cyanophenyl)-N-ethyl-8-(pyrazolo[l,5-a]pyridin-3-yl)imidazo[l ,2- c]pyrimidine-2-carboxamide;5-Amino-7-(3-cyanophenyl)-N-ethyl-8-(5-methyl-lH-pyrazol-4-yl)imidazo[l,2- c]pyrimidine-2-carboxamide;5 -Amino-7-(3 -cy anopheny l)-N-ethy l-8-( 1 -ethy 1- 1 H-py razol-5 -y l)imidazo [1,2- cJpyrimidine-2-carboxamide;5 -Amino-7-(3 -cy anopheny l)-Ar-ethy l-8-( 1 -isopropyl- l / / -py razol-5 -y liimidazo [1,2- c]pyrimidine-2 -carboxamide;5-Amino-7-(3-cyanophenyl)-A-etiiyl-8-(l-propyl-l / / -pyrazol-5-yl)imidazo[l,2- c]pyrimidine-2 -carboxamide;5-Amino-7-(3 -cy anopheny l)-N-ethyl-8-(pyrimidin-4-yl)imidazo[l,2-c]pyrimidme-2- carboxamide;5-Amino-7-(3 -cy anopheny l)-8-(2, 3 -dihydro-[l, 4]dioxino[2, 3-b]pyridin-8-y l)-N- ethyiimidazo[l,2-c]pyrimidine-2-carboxamide; and5-Amino-7-(3-cyanophenyl)-8-cyclopropyl-N-ethylimidazo[l,2-cjpyrimidine-2- carboxamide;or a pharmaceutically acceptable salt thereof.

43. The compound of claim 2, selected from:3 -(5-Amino-2-(pyridin-2-ylmethyl)-8-(pyrimidin-4 -yl)-[l,2,4]triazolo[l , 5 - c]pyrimidin-7-yl)benzomtrile;3-(5-Ammo-8-(l-ethyl-l / / -pyrazol-5-yl)-2-(pyridin-2-ylmethyl)-[l,2,4]triazolo[l,5- c]pyrimidin-7-yl)benzonitrile;3-(5-Amino-8-(l-propyl-li / -pyrazol-5-yl)-2-(pyridm-2-ylmethyl)-[l,2,4]triazolo[l,5- c j py rims din -7-y l)benzonitrile ;3-(5-Amino-2-(pyridin-2-ylmetiiyl)-8-(qimiolm-5-yl)-[l,2,4]triazolo[l,5-c|pyrimidm-7-y l)benzonitriie ;3-(5-Amino-8-(5-fluoropyrimidin-4-y l)-2 -(hydroxy (phenyl)methyl)- [ 1 ,2,4]triazolo[ 1 ,5-cjpy rimidin-7-y l)benzonitrile;3-(5-Amino-8-(5-fluoropyrimidin-4-yl)-2-(pyridin-2-ylmethyl)-[l,2,4]triazolo[l,5- c']pyrimidin~7-yl)benzomtrile;3-(5-Amino-2-((2 -hydroxy elhylamino)(phenyl)methyl)-8-(pyridin-4-yl)-[l ,2,4]triazolo[l,5-c]pyrimidin-7-yl)benzonitrile;3-(5-Amino-2-(cyclohexyhnethyl)-8-(l-ethyl-l / / -pyrazol-5-yl)-[l,2,4]triazolo[l,5- c j py rims din -7-y l)benzonitrile ;3-(5-Amino-2-(2-fluorobenzyl)-8-(pyrimidin-4-yl)-[l,2,4]triazolo[l,5-c]pyrimidm-7- ylibenzonitrile;3-(5-Ammo-2-((2-fluorophenyl)(hydroxy)methyl)-8-(pyrimidm-4-yl)-[l,2,4]triazolo[l,5-c]pyrimidin-7-yl)benzonitrile;3-(5-Amino-2-((6-methylpyrid -2-yl)methyl)-8-(pyrimidm-4-yl)-[l,2,4jtriazolo[l,5- c']pyrimidin~7-yl)benzomtrile;3-(5-Amino-8-(l-ethyl-l / / -pyrazol-5-yl)-2-((3-fluoropyridin-2-yl)methyl)-[l ,2,4]triazolo[l,5-c]pyrimidin-7-yl)benzonitrile;3-(5-Amino-8-(l-ethyl-l / / -pyrazol-5-yl)-2-((3-methoxypyridin-2-yl)methyl)- il,2,4]triazolo[T,5-c]pyrimidin-7-yl)benzonitrile;3 -(5- Amino-2-(2-(l -methy i- IH -pyrazol-4-y l)benzy l)-8-(pyrimidm-4-yl)- [l ,2,4jtriazolo[l,5-cjpyrimidin-7-yl)benzonitrile;3-(5-Amino-2-(benzo|d isoxazol-3-ylmetliyl)-8-(l-ethyl-l / / -pyrazol-5-yl)- [ 1 ,2,4]triazolo [ 1 ,5 -c]py rimidin-7-y Ijbenzoniirile;3-(5-Amino-8-(l-ethyl-l / / -pyrazol-5-yl)-2-((l-methyl-l / / -indazol-3-yl)methyl)-[l,2,4]triazolo[l,5-c]pyrimidin-7-yl)benzonitrile;3-(5-Amino-2-((3-hydroxyazetidm-l-yl)methyl)-8-(pyrimidin-4-yl)-[1.2.4]triazolo[l,5-c]pyrirnidin-7-yl)benzonitrile;3-(5-Ammo-8-(3-methylpyridin-4-yl)-2-(pyridm-2-ylmethyl)-[l ,2,4]triazolo[ l,5- c]pyrimidin-7-yT)benzonitrile;3-(5-Ammo-8-(2-methoxy-6-methylpyridm-4-yl)-2-(pyridin-2-ylm ethyl)-[1.2.4]triazolo[l,5-c]pyrimidin-7-yl)benzonitrile;3-(5-Ammo-8-(pyrazolo[l ,5- / >]pyridazin-3-yl)-2-(pyridm-2-ylmethyl)-[1.2.4]triazolo[l,5-c]pyrimidin-7-yl)benzonitrile;3-(5-Amino-8-(4-methyloxazol-5-yl)-2-(pyridin-2-ylmethyl)-[l,2,4]triazolo[l,5- c]pyrimidm-7-yl)benzonitrile;3-(5-Amino-8-(4-(hydroxymeihyl)-2-methyloxazol-5-yl)-2-(pyridin-2-ylinethyl)-[1.2.4]triazolo[l,5-c]pyrimidin-7-yl)benzonitrile;3-(5-Amino-8-(4-(methoxymethyl)-2-methyloxazol-5-yl)-2-(pyridin-2-ylmethyl)-[1.2.4]triazolo[l,5-c]pyrimidin-7-yl)benzonitrile;(S)-3-(5-ammo-2-(hydroxy(phenyl)methyl)-8-(pyrimidin-4-yl)-[l,2,4]triazolo[l,5- c]pyrimidin-7-yl)benzonitrile;(i?)-3-(5-amino-2-(hydroxy(plienyl)methyl)-8-(pyrimidin-4-yl)-[l,2,4]triazolo[l,5- c] py rim idin-7 -y 1) benzonitrile ;3-(5-Amino-2 -benzoyl-8-(pyrimidin-4-yl)-[ 1,2,4] triazolo[l, 5-c]pyrimidin-7- yl)benzonitrile;3-(5-Amino-8-(l-ethyl-l / / -pyrazol-5-yl)-2-(l-phenylcyclopropyl)-[l,2,4]triazolo[l,5- c]pyrimidin-7-yl)benzonitrile;3-(5-Amino-2-((cyano(phenyl)methyl)amino)-8-(pyrimidin-4-yl)-[l,2,4]triazolo[l,5- c]pyrimidin-7-yl)benzonitrile;3-(5-Ammo-8-(pyridin-4-yl)-2-(tetrahydrofuran-3-yl)-[l ,2,4]triazolo[l,5-c]pyrimidin- 7-yl)benzonilrile; and3-(5-Ammo-2-(phenyl(pyridm-2-yloxy)methyl)-8-(pyrimidin-4-yl)- [ 1 ,2,4]triazolo[ 1 ,5-cjpy rimidin-7-y ljbenzonitrile;or a pharmaceutically acceptable salt thereof.

44. The compound of claim 2, selected from:3-(5-Amino-2-(2-fluoro-6-(((37i,4 / ?)-3-fluoro-4-hydroxypyrrolidin-l- yl)methyl)benzyl)-8-(pyrimidm-4-y l)-[l, 2,4]triazolo[l,5-c]pyrimidin-7-yl)benzonitrile;l-(2-((5-Amino-7-(3-cyanoplienyl)-8-(pyrimidin-4-yl)-[l,2,4]triazolo[l,5- c]pyrimidin-2-y3)methy!)-3-fliiorobenzy!)piperidine-4-carboxylic acid;Ar-(2~((5-Amino~7-(3-cyariophenyi)~8-ipyrirnidin-4-yl)-[l,2,4]triazolo[l ,5- c]py rimidin-2-y l)me thy l)-3 -fluorobenzy 1) -V-me thy lme thane sulfonamide ;3-(5-Amino-2-(2-((2,5-dioxoimidazolidin-l-yl)methyl)-6-f]uorobenzyl)-8-(pyrimidin-4-yl)-[l,2,4]triazolo[l,5-clpyrimidin-7-yl)benzonitrile; and3-(5-Ammo-2-((2,6-difluorophenyl)(hydroxy)methyl)-8-(pyrimidin-4-yl)- [ 1 ,2,4]triazolo[ 1 ,5-cjpy rimidin-7-y IJbenzonitrile;or a pharmaceutically acceptable salt thereof.

45. The compound of claim 2, selected from:3-(5-Amino-2-((5-(pyridm-2-yl)-lH-tetrazol-l-yl)methyl)-8-(pyrimidm-4-yl)-[l,2,4]triazolo[l,5-c]pyrimidin-7-yl)benzonitrile;3 -(2-((5 -( lH-Pyrazol- 1 -y 1)- lH-tetrazol- 1 -y l)methy l)-5 -amino-8-(pyrimidin-4-y 1)-[l ,2,4]triazolo[l,5-c]pyrimidin-7-yl)benzonitrile;3-(5-Amino-8-(pyrmtidin-4-yl)-2-((5-(thiazol-4-yl)-lH-tetrazol-l-yl)methyl)-[1.2.4]triazolo[l,5-c]pyrimidin-7-yl)benzonitrile;3 -(5-Amino-2-((5 -methy 1-3 -(trif!uoromethy 1)- 1 H-pyrazol- 1 -y l)methyl)-8-(pyrimidin-4-yl)-[l,2,4]triazolo[ l,5-c]pyrimidin-7-yl)benzonitrile;3-(5-Amino-8-(4-etbyloxazol-5-yl)-2-(pyridin-2-ylmethyl)-[l,2,4]triazolo[l,5- c] py rimidin- 7 -y l)benzonitr ile ;3 -(5- Amino-8-( 1 -ethyl- 1 H- 1,2,3 -triazol-5-y l)-2-(pyridin-2-y lmethyl)-[1.2.4]triazolofl,5-c]pyrimidin-7-yl)benzonitrile;3-(5-Amino-8-(4-methyloxazol-5-yl)-2-((3-methylpyridin-2-yl)methyl)-[1.2.4]triazolo[l,5-c]pyrimidin-7-yl)benzonitrile;3-(5-Amino-2-((3-fluoropyridin-2-yl)methyl)-8-(4-(hydroxymethyl)-2-methyloxazol-5-yl)-[l,2,4]triazolo[l,5-c]pyrimidin-7-yl)benzomtrile;3-(5-Amino-2~(2~((l,l-dioxidoisothiazo3idin~2-yi)methyl)~0-fluorohenzyi)-8~(pyrimidin-4-yl)-[l,2,4]triazolo[l ,5-c]pyrmiidin-7-yl)benzonitrile;3-(5-Amino-2-(2-fluoro-6-((3-methyl-2,5-dioxoimidazolidin-l -yl)methyl)benz>d)-8- (pyrimidin-4-y3)-[ 1 ,2,4]triazolo [1,5 -c]py rimidin-7-y l)benzonitriie;3-(5-Ammo-2-((3-fluoropyridin-2-yl)methyl)-8-(pyrimidiii-4-yl)-[l ,2,4]triazolo[ l,5- c]pyrimidin-7-yl)benzonitrile;3 -(5 -Amino-8-(4-methy loxazol-5 -y l)-2-((6-(trifluoromethy l)pyridin~2-y l)methy 1)~[l ,2,4]triazolo[l,5-c]pyrimidin-7-yl)benzonitrile;3-(5-Amino-8-(4-methyloxazol-5-yl)-2-(pyridin-2-ylmethyl)-[ l,2,4]triazolo[l,5- c]pyrimidin-7-yl)-2-fluorobenzonitrile;3-(5-Amino-2-((3-(hydroxymethyl)pyridin-2-yl)methyl)-8-(4-methyloxazol-5-yl)-[l,2,4]triazolo[l,5-c]pyrimidin-7-yl)benzonitrile;3-(5-Amino-2-((l-methyl-lH-pyrazol-3-yl)methyl)-8-(4-methyloxazol-5-yl)- [ 1 ,2,4]triazolo[ 1 ,5-c jpy rimidin-7-y Ijbenzonitrile;3 -(5-Amino-2-(( 1 -methy 1- 1 H-py razol-3 -y l)methy l)-8-(oxazol-5 -y 1)- [ 1 , 2,4] triazolo [1,5 -c Jpy rimidin -7 -y l)be nzonitrile ;3-(5-Amino-2-((3-methylpyridm-2-yl)methoxy)-8-(pyrimidin-4-yl)-[l ,2,4]triazolo[l,5-c]pyrimidin-7-yl)benzonitrile;3-(5-Amino-2-((6-methylpyridin-2-yl)methoxy)-8-(pyrimidin-4-yl)-[l,2,4]triazolo[l,5-c]pyrimidin-7-yl)benzonitrile;2-((5-Amino-7-(3-cyanophenyl)-8-(pyrimidin-4-yl)-[l,2,4]triazolo[l,5-c]pyrimidin-2- y l)me thoxy )benzonitrile ; and3-(5-Amino-2-(((3-methylpyridin-2-yl)methyl)amino)-8-(pyrimidin-4-yl)- [ 1 ,2,4]triazolo[ 1 ,5-c jpy rimidin-7-y Ijbenzonitrile;or a pharmaceutically acceptable salt thereof.

46. A pharmaceutical composition comprising a compound of any one of claims 1-45, or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable excipient or carrier.

47. A method of inhibiting an activity of an adenosine receptor, comprising contacting the receptor with a compound of any one of claims 1-45, or a pharmaceutically acceptable salt thereof.

48. A method of treating a disease or disorder in a patient, wherein the disease or disorder is associated with abnormal expression of A2A or A2B receptors, comprising administering to said patient a therapeutically effective amount of a compound of any one of claims 1-45, or a pharmaceutically acceptable salt thereof.

49. The method of claim 48, wherein the disease or disorder is cancer, an inflammatory disease, a cardiovascular disease, or a neurodegenerative disease.

50. The method of claim 49, wherein the cancer is bladder cancer, lung cancer, melanoma, breast cancer, cervical cancer, ovarian cancer, colorectal cancer, pancreatic cancer, esophageal cancer, prostate cancer, kidney cancer, skin cancer, thyroid cancer, liver cancer, uterine cancer, or renal cell carcinoma.

51. The method of claim 49, wherein the inflammatory disease is pulmonary' inflammation.

52. The method of claim 51 , wherein the pulmonary inflammation is bleomycin-induced pulmonary fibrosis.

53. The method of claim 49, wherein the inflammatory disease is an adenosine receptor dependent allergic reaction or adenosine receptor immune reaction.

54. The method of claim 53, wherein the adenosine receptor dependent allergic reaction is A2B receptor dependent.

55. The method of claim 49, wherein the inflammatory disease is a respiratory' disorder, sepsis, reperfusion injury, or thrombosis.

56. The method of claim 49, wherein the cardiovascular disease is coronary artery- disease, cerebrovascular disease, peripheral artery' disease, aortic atherosclerosis, or aneurysm.

57. The method of claim 56, wherein the coronary artery' disease is myocardial infarction, angina pectoris, or heart failure.

58. The method of claim 56, wherein the cerebrovascular disease is stroke or transient ischemic attack.

59. The method of claim 49, wherein the neurode generative disease is Parkinson’s disease.

60. The method of claim 48, wherein the disease or disorder is diabetes or insulin resistance.

61. A method of treating or pre venting atherosclerotic plaque formation in a patient in need thereof, comprising administering to said patient a therapeutically effective amount of a compound of any one of claims 1-45, or a pharmaceutically acceptable salt thereof.