Aromatic heterocyclic compound, and preparation method therefor and use thereof

IL330289A0Pending Publication Date: 2026-08-01SHANGHAI INNOVSTONE THERAPEUTICS CO LTD
View PDF 0 Cites 0 Cited by

Patent Information

Application Number
IL330289
Authority / Receiving Office
IL · IL
Patent Type
Applications
Current Assignee / Owner
Priority Date
2024-06-28
Filing Date
2024-12-20
Publication Date
2026-08-01

AI Technical Summary

Technical Problem

After long-term use of existing antihypertensive drugs, they can easily lead to a rebound in aldosterone levels, limiting their efficacy, and adverse reactions to some drugs such as renal function damage and hyperkalemia are unfavorable to patients with renal injury and have limited clinical application.

Method used

A class of novel structurally aromatic heterocyclic compounds have been developed as inhibitors of aldosterone synthetase (CYP11B2) to reduce their levels in circulating plasma by blocking the biosynthesis of aldosterone.

Benefits of technology

These compounds showed strong CYP11B2 inhibitory effect, had good selectivity, and showed good oral absorption performance in monkeys, with potential effects on the treatment of diseases related to refractory hypertension and aldosterone.

✦ Generated by Eureka AI based on patent content.
Patent Text Reader

Abstract

Provided are a compound represented by formula (I), and a stereoisomer, tautomer or pharmaceutically acceptable salt thereof. The compound represented by formula (I) serves as a CYP11B2 inhibitor. The compound and a pharmaceutical composition containing same are useful for the preparation of a drug for treating and / or preventing CYP11B2-mediated diseases.
Need to check novelty before this filing date? Find Prior Art