Process for the preparation of n-[(1s,2e)-1-cyclopropyl-3-(methanesulfonyl)prop-2-en-1-yl]-2-(1,1-difluoroethyl)-4-phenoxypyrimidine-5-carboxamide
IL330454A0Pending Publication Date: 2026-08-01VIVIDION THERAPEUTICS INC
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Patent Information
- Application Number
- IL330454
- Authority / Receiving Office
- IL · IL
- Patent Type
- Applications
- Current Assignee / Owner
- Priority Date
- 2024-05-08
- Filing Date
- 2025-01-09
- Publication Date
- 2026-08-01
AI Technical Summary
Technical Problem
There is a need for improved processes to prepare -[(iS,2E)-i-cyclopropyl-3-(methanesulfonyl)prop-2-en-i-yl]-2-(i,i-difluoroethyl)-4-phenoxypyrimidine-5-carboxamide that are efficient for large-scale synthesis, avoid complex and low-yielding chemical steps, and minimize temperature sensitivity and racemization.
Method used
The process involves a series of chemical reactions, including the formation of intermediates using flow chemistry and telescoped reactions, coupled with recrystallization in specific solvent systems, to achieve high yield and purity of the final compound.
Benefits of technology
The described process enables high-quality production of the compound with improved control over impurities, ensuring high yield and selectivity, suitable for large-scale synthesis.
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Abstract
The present invention relates to a process for the preparation of compound (I), or a pharmaceutically acceptable salt thereof, which is useful for the treatment of medical disorders and diseases, most especially by WRN inhibition.
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