Compositions and methods for treating and preventing prekallikrein-associated conditions

IL330494APending Publication Date: 2026-09-01IONIS PHARMACEUTICALS INC
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Patent Information

Application Number
IL330494
Authority / Receiving Office
IL · IL
Patent Type
Applications
Current Assignee / Owner
Priority Date
2020-03-13
Filing Date
2021-03-12
Publication Date
2026-09-01

AI Technical Summary

Technical Problem

Current treatments for hereditary angioedema and macular edema are inadequate in effectively reducing prekallikrein (PKK) activity and associated symptoms, as existing therapies often provide limited relief and are not sufficient for all patients, particularly those with refractory cases.

Method used

Administration of the oligomeric compound ISIS 721744, which specifically targets PKK RNA and protein, reducing its activity and ameliorating symptoms such as swelling, nausea, and vision disturbances through various dosing regimens and formulations.

Benefits of technology

ISIS 721744 effectively reduces PKK activity and associated symptoms in patients with hereditary angioedema and macular edema, providing significant symptom relief and reducing the frequency and severity of attacks, even in refractory cases, with a range of dosing options to accommodate individual patient needs.

✦ Generated by Eureka AI based on patent content.

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Abstract

Provided herein are methods of administering ISIS 721744 for ameliorating edema, and methods of reducing prekallikrein (PKK) RNA, protein or activity in a human subject in need thereof. In certain instances, methods are useful for ameliorating at least one symptom of hereditary angioedema. Such symptoms of hereditary angioedema include, but are not limited to, nausea, vomiting, itching, headache, fatigue, abdominal pain, shortness of breath, rhinitis, anaphylaxis, bronchoconstriction, and swelling. In certain instances, methods are useful for ameliorating at least one symptom of macular edema. Such symptoms of macular edema include, but are not limited to, impaired vision and vision loss.
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