Phenacylamine derivatives
Patent Information
- Application Number
- IL89066
- Authority / Receiving Office
- IL · IL
- Patent Type
- Applications
- Current Assignee / Owner
- Priority Date
- 1985-09-10
- Filing Date
- 1985-09-10
- Publication Date
- 1989-08-15
- Estimated Expiration
- Not applicable · inactive patent
AI Technical Summary
Current methods for preparing 4-phenylpyrrole derivatives, which are used as fungicides, face inefficiencies in the production process and require multiple steps with low thermal stability of starting materials, necessitating the development of novel intermediates and processes for improved yield and purity.
A novel process involving phenacylamine derivatives, specifically 2,3-dichlorophenacylamine, is used to produce 4-phenylpyrrole compounds through direct reaction with acrylonitrile in the presence of a base, allowing for cyclization in a single reaction vessel without intermediate isolation, utilizing acid addition salts and suitable solvents to achieve high yield and purity.
This process enhances the production efficiency of fungicidally active 4-phenylpyrrole compounds by simplifying the synthesis steps, improving thermal stability, and achieving high purity and yield, making the compounds suitable for use as effective fungicides.