Syringe suitable for hydrogen peroxide solution and its kit

Abstract

A syringe that prevents hydrogen peroxide decomposition is provided. The object of the present invention is to provide a syringe comprising a part in contact with a hydrogen peroxide solution, wherein said part is made of a cycloolefin polymer (COP) or a cycloolefin copolymer (COC).

Description

Description Syringe suitable for hydrogen peroxide solution and its kit Technical background The present invention relates to a syringe, and more particularly to a syringe made of a material having a low amount of metal ion leaching in the presence of a hydrogen peroxide solution compared to glass. Background Hydrogen peroxide solution is used industrially as a bleaching agent, and as a disinfectant in the food industry. Hydrogen peroxide solution containing 2.5 to 3.5% (w / v) hydrogen peroxide (known as "oxidol" in the Japanese Pharmacopoeia) is used for pharmaceutical purposes as a disinfectant. This hydrogen peroxide solution can be used as a radiation sensitizer by mixing it with a solution of hyaluronic acid or a salt thereof such as sodium hyaluronate in a predetermined ratio, and then injecting the mixture into the tumor before the radiation therapy dose (Patent Document 1). Prior knowledge document Patent document Patent Document 1: WO2008 / 041514 Summary of the invention Problems to be solved by invention Because hydrogen peroxide decomposes rapidly when removed from the special storage container that protects it from light, when used as a radiation sensitizer as disclosed in Patent Document 1, it must be withdrawn in an appropriate volume and weight and then mixed with the sodium hyaluronate solution just before injection. This is a double burden for the medical personnel treating the patient. Either the hospital pharmacy must withdraw the hydrogen peroxide solution and mix it with the sodium hyaluronate, or a physician must do this in-patient. In the former case, the pharmacy personnel incur additional exposure and there is a risk of delay in transferring the injection mixture from the pharmacy to the patient. In the latter case, the medical personnel in-patient, who prepare the patient for radiography, incur additional burden. In both cases, the complexity of withdrawing and mixing solutions increases, increasing the risk of errors that may undermine drug therapy or endanger the patient. Additionally, if the hydrogen peroxide solution is prefilled using a syringe made of conventional glass (e.g., borosilicate glass), the glass syringe will expand during storage of the hydrogen peroxide solution and its gasket will be pushed back. This may interfere with long-term storage of the hydrogen peroxide solution in such a glass syringe. Problem-solving tools The object of the invention is to provide a syringe comprising a part in contact with a hydrogen peroxide solution, Where this part is made of cycloolefin polymer (COP) or cycloolefin copolymer (COC). By using this syringe, it is possible to limit the decomposition of hydrogen peroxide in the hydrogen peroxide solution. Therefore, by using prefilled syringes, the hydrogen peroxide solution can be stored for a long time. The syringe may be suitable for pre-filling with hydrogen peroxide solution. The syringe may additionally include a hydrogen peroxide solution in the syringe. The hydrogen peroxide solution may include hydrogen peroxide and water. The hydrogen peroxide solution may contain an additive. The syringe may additionally include a nozzle at the syringe needle mounting portion. Rapid administration is possible when the syringe is already equipped with a nozzle. The nozzle may include a nozzle portion and a converter portion connected to the syringe needle mounting portion. The nozzle part may be a needle or a spray nozzle. The needle may have a groove in an echogenic pattern on its outer surface. The syringe may additionally include a guard. The nozzle may be covered with a guard. The guard may include a support member, a nozzle guard portion connected to one end of the support member, and an engagement portion connected to the other end of the support member. The nozzle protection portion may include a space capable of accommodating the nozzle portion. The engagement portion may include a movable portion and may be movably connected via the movable portion to the other end of the support member. The space may be located along the inner surface of the side wall of the nozzle guard. The support member may include a primary arm, a secondary arm, a primary movable part, a secondary movable part, and a third movable part. One end of the primary arm may be movably connected to the nozzle guard via a primary movable portion. The other end of the primary arm may be movably connected to an end of the secondary arm via a second movable portion. The movable part may include a rail part connected to the nozzle protection part and a rail holding part connected to the engagement part. The rail holding portion may slideably hold the rail portion. The space may be located inside the nozzle guard. The nozzle protection part may have a hollow structure. The syringe may additionally include a syringe pump. The concentration of hydrogen peroxide in hydrogen peroxide solution may be 0.01 to 40% (w / v). Another object of the present invention is to provide a kit comprising a syringe and a nozzle. By using the kit, there is no need to select a nozzle for the stone. As a result, rapid administration can be facilitated. The kit may additionally include a protection to cover the nozzle part. Impact of the invention According to the present invention, it is possible to provide a prefilled syringe capable of storing a hydrogen peroxide solution for a long time until it is used as a radiation sensitizer. As a result, rapid administration can be performed. In addition, safe administration can be performed by equipping the nozzle with a guard. By using a needle as the nozzle, the hydrogen peroxide solution can be conveniently and safely administered. Alternatively, by using a spray nozzle as the nozzle, the hydrogen peroxide solution can be conveniently and safely administered by spraying. By using a syringe pump, the prefilled syringe can operate stably, and deliver the prefilled solution in a predetermined appropriate amount. Brief explanation of maps Figure 1 shows a schematic view of a prefilled syringe containing hydrogen peroxide solution according to the present example. Figure 2 shows a prefilled syringe with a needle according to the present example. Figure 3 shows a prefilled syringe with a spray nozzle according to the present example. Figure 4 shows a partially enlarged cross-sectional view of a spray nozzle according to the present example. Figure 5 shows a prefilled syringe with a shield according to the present example. Figure 6 shows a prefilled syringe with a movable shield in the protected position according to the present example. Figure 7 shows a prefilled syringe with a movable shield in the dispensing position according to the present example. Figure 8 shows a prefilled syringe with a lift-off guard in the guard position according to the present example. Figure 9 shows a prefilled syringe with a slide-type guard in the dispensing position according to the present example. Figure 10 shows a prefilled syringe equipped with a syringe pump according to the present example. Figure 11 is a schematic diagram showing the operation of a syringe pump according to the present example. Figure 12 is a graph showing the residual hydrogen peroxide values ​​of each syringe material in the example. Description of samples Definition For convenience, specific terms used in the context of the present disclosure are collected here. Unless otherwise defined, all technical and scientific terms used herein have the same meaning as would be commonly understood by a person of ordinary skill in the art to which the invention pertains. The singular terms "a", "an", "the Although the numerical and parameter ranges that describe the broad scope of the invention are approximate, the numerical values ​​stated in the specific examples are expressed as precisely as possible. However, no numerical value inherently contains specific errors resulting from deviations from the standard obtained in the relevant test measurements. Also, as used herein, the term "about" usually means 10%, 5%, 1%, or 0.5% of the given value or range. Alternatively, the term "about" means the average acceptable standard error when considered by a person of ordinary skill in the art. "Protection state" in the present description means a state in which the skin cannot access the tip of the nozzle portion by the guard, that is, a state in which administration cannot be performed. "Administration state" used in the description refers to a state in which the tip of the nozzle portion is not protected by the guard, that is, a state in which administration can be performed. Next, examples of the present invention will be described in detail. The following examples are merely illustrative and do not limit the scope of the present invention. In order to avoid repetition, descriptions will not be repeated for similar cases. Syringe A syringe according to the present example includes a portion that is in contact with the hydrogen peroxide solution, Where the said part is made of cycloolefin polymer (COP) or cycloolefin copolymer (COC). The syringe may be suitable for pre-filling with a hydrogen peroxide solution. The syringe may further comprise a hydrogen peroxide solution in the syringe. The hydrogen peroxide solution may comprise hydrogen peroxide and water. The hydrogen peroxide solution may comprise an additive. Figure 1 is a schematic diagram of a prefilled syringe (1) filled with a hydrogen peroxide solution (50) according to the present embodiment. In the present embodiment, the syringe (10), in particular the reservoir (20) of the syringe (10), is generally cylindrical in shape. In the present embodiment, the syringe (120) has a needle mounting portion (30) at one end from which the hydrogen peroxide solution (50) is discharged. In the present embodiment, the syringe (10) has a rod-insertion portion (80) at its other end for inserting a piston rod (70). In the present embodiment, the syringe (10) has a flange (90) provided around the rod-insertion portion (80). In order to seal the filled hydrogen peroxide solution (80), the prefilled syringe (1) shown in Figure 1 has a cap (40) provided at the needle mounting portion (30) and a piston rod (70) inserted from the rod insertion portion (80), the piston rod (70) having a gasket (60). In the present example, a syringe for a hydrogen peroxide solution means a syringe that has a low hydrogen peroxide decomposition capability in a hydrogen peroxide solution. In the present example, a hydrogen peroxide solution means a solution in which the solvent (e.g., water) comprises hydrogen peroxide and, if necessary, an additive (e.g., phosphoric acid and phenastin other than a gel carrier). In one example, the hydrogen peroxide solution is essentially free of a gel carrier (e.g., hyaluronic acid, hyaluronic acid salt, hydrogel and gelatin). "Substantially free" means (for example) that the concentration of the gel substrate in the solution is less than 0.1% by weight, less than 0.05% by weight, less than 0.01% by weight or less than 0.001% by weight or less than 0.1%(w / v), less than 0.05%(w / v), less than 0.01%(w / v), less than 0.005%(w / v) or less than 0.001%(w / v). In another embodiment, the hydrogen peroxide solution does not include a gel bed. In the present embodiment, the syringe may be made of a single material or may be made of multiple materials (including a multilayer structure such as a coating). In the case where the syringe is made of a single material, the entire syringe is made of a plastic such as COP or COC. In the case where the syringe is made of several materials, the part of the syringe that comes into direct contact with the hydrogen peroxide solution is made of plastic, the remaining part may be made of a material with high hydrogen peroxide decomposition ability, such as glass. In addition, all parts that come into contact with the hydrogen peroxide solution need to be made of plastic. Therefore, the main part, such as the inner surface of the syringe barrel, may be made of plastic. In other words, the parts that may come into contact with the hydrogen peroxide solution, such as the piston rod, luer lock, cap, and washer, need to be made of plastic. In addition, a lubricant, such as silicone oil, may be applied to the inner surface of the syringe barrel. The degradability of hydrogen peroxide can be determined as the ratio of the hydrogen peroxide concentration in the hydrogen peroxide solution after storage to the hydrogen peroxide concentration in the hydrogen peroxide solution before storage under specific temperature conditions (residual hydrogen peroxide content). Storage is carried out in a sealed state. The temperature conditions are not limited, but may be 35 °C, 37 °C, 40 °C, or 60 °C. The storage period is not limited, but may be one week, two weeks, three weeks, or four weeks, or four weeks or more. The hydrogen peroxide concentration in the hydrogen peroxide solution before storage may be any concentration, for example in the range of 0.01 to 40% (w / v). In one example, the degradability of hydrogen peroxide in plastic is lower than that in glass. The residual amount of hydrogen peroxide in the plastic may be 70% or more, preferably 75% or more, most preferably 78% or more, most preferably 80% or more under conditions where a solution containing 2.5 to 3.5% (w / v) hydrogen peroxide is stored sealed for 4 weeks at 60 °C.The amount of hydrogen peroxide in a hydrogen peroxide solution can be determined by titration with a potassium permanganate solution according to an oxidol determination method described in the Japanese Pharmacopoeia. In the present example, the plastic may include, but is not limited to, COP, COC, and polypropylene, as long as the plastic has a lower hydrogen peroxide degradation capability than glass. Nozzle Figure 2 shows a prefilled syringe (1) with a nozzle (100). The nozzle (100) is connected to the syringe mounting portion (30) of the prefilled syringe (1). The nozzle (100) may be preinstalled on the syringe mounting portion (30) of the prefilled syringe (1) or may be included in a kit containing the prefilled syringe (1). When the nozzle (100) is preinstalled on the needle mounting portion (30) of the prefilled syringe (1), the nozzle (100) (or the prefilled syringe (1)) preferably includes a blocking mechanism that prevents leakage of the hydrogen peroxide solution (50) until the prefilled syringe (1) is used. The nozzle (100) includes a nozzle portion (110) and a transducer portion connected to the nozzle portion (110). The transducer portion (120) is connected to the needle mounting portion (30) of the prefilled syringe (1). The interior of the nozzle portion (110) is in fluid communication with the interior of the transducer portion (120). The prefilled syringe 1 shown in Figure 2 includes a needle 111 as the nozzle portion 110. In another example, the prefilled syringe 1 includes a spray nozzle 112 as the nozzle portion 110 (Figure 3). The spray nozzle 112 shown in Figure 3 is integrally molded into the converter portion 120. In another example, the spray nozzle 112 is detachably connected to the converter portion 120. Figure 4 shows a partial enlarged cross-sectional view of the spray nozzle (112) shown in Figure 3. The cross-sectional view of Figure 4 shows a cross-section of the prefilled syringe (1) shown in Figure 3 taken through the central axis AA. The spray nozzle (112) includes an outlet (112A), an orifice (112B), and an inlet (112C). The inside diameter of the outlet (112A) decreases from the outside of the spray nozzle (112) toward the orifice (112B) in accordance with the present embodiment. The inside diameter of the inlet (112C) decreases from the inside of the spray nozzle (112) toward the orifice (112B) in accordance with the present embodiment. Depending on the desired particle size of the hydrogen peroxide solution (50), the inside diameter of the orifice (112B) can vary. The inner diameter of the outlet (112A) may be the same as the inner diameter of the orifice (112B), and the inner diameter of the inlet (112C) may be the same as the inner diameter of the orifice (112B). The inner diameter of the spray nozzle (112) may be fixed. The (111) needle may have a groove with an echogenic pattern on its outer surface. The echogenic pattern is not particularly limited as long as it is a groove pattern that improves the visibility of the (111) needle even in the ultrasonic image. Protector Figure 5 shows a prefilled syringe (1) equipped with a shield (200). The shield (200) can cover the nozzle (100). The shield (200) may be removably connected to the conversion portion (120) (or prefilled syringe (1)) of the nozzle (100) by a fitting or screw. The shield (200) may include a blocking mechanism that prevents leakage of the hydrogen peroxide solution (50) from the prefilled syringe (1). The blocking mechanism can prevent leakage of the hydrogen peroxide solution (50) from the prefilled syringe (1), for example, by contacting the inside edge of the shield (200) with the edge of the nozzle (100). Movable guard Figures 6 and 7 show a prefilled syringe 1 equipped with a movable guard (300). The movable guard (300) shown in Figure 6 protects the nozzle portion 110. The movable guard (300) shown in Figure 7 is for exposing the nozzle portion (110). The movable guard (300) includes a support member (320), a nozzle guard portion (310) connected to one end (321) of the support member (320), and an engagement portion (330) connected to the other end (322) of the support member (320). The engagement member (330) is connected to the other end (322) of the support member (320) via a movable portion (340). The engagement portion (330) is removably connected to the conversion portion (120). The nozzle guard (310) of the movable guard (300) has a space that can accommodate the nozzle portion (110) of the nozzle (100) in the nozzle guard (310). In the present example, the space is a groove (311). The groove (311) is formed in the side wall (314) of the nozzle guard (310). The front end (312) of the nozzle guard (310) is closed. The rear end (313) of the nozzle guard (310) is open. The movable guard (300) can remove the nozzle portion (110) of the nozzle (100) from the groove (311) of the nozzle guard portion (310) by rotating the movable guard (300) about the movable portion (340) as the axis of rotation, without physically separating the movable guard (300) from the conversion portion (120), and vice versa. The movable guard (300) may include a plurality of support members (320). When the movable guard (300) includes a plurality of support members (320), each of the support members (320) may be connected via a movable portion. The engagement portion (330) may engage with the conversion portion (120) of the nozzle (100) or the prefilled syringe (1). In the present example, the movable portion (340) is a pivot portion including, but not limited to, a shaft. The movable portion (340) may be a curved portion that can be bent. When the movable portion (340) is a curved portion, the support member (320) and the engagement portion (330) may be integrally formed. Sliding type guard Figures 8 and 9 show a prefilled syringe 1 equipped with a slide-type guard (400). The slide-type guard (400) shown in Figure 8 protects the nozzle portion (110). The slide-type guard (400) shown in Figure 9 is positioned to expose the nozzle portion (110). The slide-type guard (400) includes a support member (420), a nozzle guard portion (410) connected to one end of the support member (420), and an engagement member (430) connected to the other end of the support member (420). The holding portion (430) is detachably connected to the conversion portion (120). The support member (420) includes a primary arm (421), a secondary arm (422), a primary movable portion (441), a secondary movable portion (442), and a third movable portion (443). In the present embodiment, the nozzle guard portion (410) has a hollow structure, and has a space that can accommodate the front end of the nozzle portion (110) from the rear end (413) of the nozzle guard portion (410). When the slide-type guard (400) is in the guarding position, the front end of the nozzle portion (110) is located in the nozzle guard portion (410). When the slide-type guard (400) is in the dispensing position, the front end of the nozzle portion (110) protrudes from an opening (411) in the nozzle guard portion (410). In the present example, the opening (411) has a cross-shaped shape, but it may have another shape. One end (421A) of the primary arm (421) is movably connected to the nozzle guard portion (410) via a primary movable portion (441). The other end (421B) of the primary arm (421) is movably connected to one end (422A) of the second arm (422) via a second movable portion (442). The other end (422B) of the second arm (422) is movably connected to the engagement portion (430) via a third movable portion (443). By rotating each arm relative to the central axis of each movable part such that the second movable part (442) is positioned away from the nozzle (100), the nozzle guard (410) can be moved in the direction of the conversion part (120), which results in the nozzle part (110) of the nozzle (100) being able to be removed from the opening (411) of the nozzle guard (410) without physically separating the slide-type guard (400) from the conversion part (120), and vice versa. The number of arms and the number of moving parts can be changed if necessary. The length of the arm can be changed according to the length of the nozzle part (110). Another example In another embodiment, the slide-type guard (400) includes a rail portion, a nozzle guard portion (410) connected to one end of the rail portion, and a rail holding portion connected to the other end of the rail portion. The rail holding portion slidably holds the rail. The rail holding portion is detachably connected to the conversion portion (120). An opening (411) is provided at the front end of the nozzle guard portion (410). By sliding the nozzle guard portion (410) in the longitudinal direction of the prefilled syringe (1), the nozzle portion (110) can be inserted into or removed from the opening (441). Syringe pump Figure 10 shows a prefilled syringe (1) equipped with a syringe pump (500). The syringe pump (500) in the present example includes slots (510) into which a flange end (90) of the prefilled syringe (1) is inserted, a holder (520) that fixes the prefilled syringe (1), a movable wall (530) that pushes the piston rod (70) of the prefilled syringe (1), a monitor (540), switches (550), a processor (560), a memory (561), a pressure sensor (562), a battery (563), and an electric motor (564). The monitor (540) and switches (550) are provided on the primary surface (501A) of the syringe pump (500). The movable wall (530) is provided on the secondary surface (501B) of the syringe pump (500). The secondary surface (501B) of the syringe pump (500) is positioned at a lower position than the primary surface (501A) of the syringe pump (500). The primary surface (501A) of the syringe pump (500) is connected to the secondary surface (501B) of the syringe pump (500) through the primary wall (502A) of the syringe pump (500). The slots (510) are formed to pass through the primary surface (501A) and the primary wall (502A) of the syringe pump (500). The movable wall (530) is connected to two threaded rods (570A) and (570B) provided on the second surface (501B). When the threaded rods (570A) and (570B) are rotated, for example, by an electric motor (564), the movable wall (530) can move in a direction to push (or pull) the piston rod (70) of the prefilled syringe (1). The movable wall (530) of the syringe pump (500) is electrically operated but may be mechanically operated. When the syringe pump (500) is used, one flange end (90) of the prefilled syringe (1) is inserted into each of the slots (510). By inserting one flange end (90) of the prefilled syringe (1) into the slot (510), the prefilled syringe (1) is prevented from moving in the direction of movement of the movable wall (530). Depending on the length of the prefilled syringe (1), each of the slots (510) can be selected. The prefilled syringe (1) is further secured by a retainer (520). The retainer (520) is configured to press the prefilled syringe (1) against the primary wall (502A) and the secondary surface (501B). By securing the prefilled syringe (1) using the retainer (520), the prefilled syringe (1) is prevented from falling out of the syringe pump (500). The operation of the syringe pump (500) is explained with reference to FIG. 11. The syringe pump (500) is driven by battery power (563). The operation of the syringe pump (500) can be adjusted by operating the switches (550). Requests from the switches (550) are processed by the processor (560). The processor (560) can read necessary information (such as a program) from the memory (561) as soon as the request is made, and can store the necessary information in the memory (561). The processor (560) can display the processing result on the monitor (540). When the processor (560) receives a request to drive the syringe pump (500), the processor (560) processes the request so that the electric motor (564) rotates. Based on information from the pressure sensor (562) connected to the movable wall (530), the processor (560) can process the information so that the electric motor (564) stops. The syringe pump (500) can adjust a flow rate, administration time, an inner diameter of the syringe, a pressure threshold, and the like, thereby enabling stable administration. Kit In another example, a kit is provided including a syringe and nozzle. The kit includes a prefilled syringe (1) and a nozzle (100). The kit may include a set of prefilled syringes (1) and nozzles (100). The kit may include a shield (200), (300), or (400) that covers the nozzle (100). The kit may include additional elements (e.g., instructions or a dosing schedule) for treating tumors with an anticancer drug or radiation. In the present example, the concentration of hydrogen peroxide in the hydrogen peroxide solution in the prefilled syringe is, for example, 0.01, 0.02, 0.03, 0.04, 0.05, 0.06, 0.07, 0.08, 0.09, 0.1, 0.5, 1, 5, 10, 15, 20, 25, 30, 35 or 40%, or may be in the range between both numerical values ​​exemplified herein, for example, 0.01 to 40% (w / v), preferably, 0.05 to 30% (w / v). Materials The material of the nozzle part (110) can be changed according to the purpose and use situation of the present embodiment. When the nozzle part is the needle (11), the material of the nozzle part (110) (i.e., the needle (111)) may be a material such as stainless steel. The material of the conversion part (120) may be resin (for example, COP, COC, polypropylene, and polycarbonate), metal, rubber, or glass. When the nozzle part (110) is the spray nozzle (112), the material of the nozzle part (110) (i.e., the spray nozzle (112)) may be resin (for example, COP, COC, polypropylene, and polycarbonate), metal, rubber, or glass. When the spray nozzle (112) is integrally formed with the conversion part (120), the same material as the conversion part (120) is used. The material of the protector (200) may include (but is not limited to) resins (for example, COP, COC, polypropylene, and polycarbonate), metal, rubber, and glass. The material of the movable protector (300) and the sliding protector (400) may be the same as the material of the protector (200). The material of the movable parts of the movable protector (300) and the sliding protector (400) (the movable part (340), the primary movable part (411), the secondary movable part (442), and the tertiary movable part (443)) may be different from the material of the other parts of the movable protector (300) and the sliding protector (400) depending on the purpose and use situation of the present embodiment. The syringe pump housing (500) may be made of metal or resin (e.g., polycarbonate). The movable wall material (530) may be different from or the same as the syringe pump housing (500). The retainer (520) may be made of metal, rubber, or resin. Examples Hydrogen peroxide solution stability test The stability test of hydrogen peroxide solution was performed using a glass syringe, a COP syringe, and a COC syringe. 1 mL of hydrogen peroxide solution was added to each syringe, sealed, and then stored at 60 °C for 4 weeks. The residual hydrogen peroxide amounts in the hydrogen peroxide solutions after storage were measured. Oxidol "KENEI" (containing 2.5 to 3.5% (w / v) hydrogen peroxide, phosphoric acid, and phenacetin) manufactured by Kenei Pharmaceutical Co., Ltd. was used as the hydrogen peroxide solution. The amount of hydrogen peroxide in the hydrogen peroxide solution was determined by titration with a potassium permanganate solution according to the method for determining oxidol described in the Japanese Pharmacopoeia. The results are shown in Figure 12. In the case of glass, the residual amount of hydrogen peroxide was 70%, while the residual amount was 70% or more in the case of COP and COC. As a result, COP and COC syringes are able to prevent the decomposition of hydrogen peroxide more than glass syringes. Explanation of references 1 prefilled syringe 10 Syringes 20 tanks 30 Needle mounting parts 40 warheads 50 hydrogen peroxide solution 60 washers 70 piston rods 80 The part where the rod enters 90 flange 100 nozzles 110 nozzle parts 111 needles 112 spray nozzles 112A output 112B aperture 112C Input 120 conversion parts 200 protection 300 moving guards 310 Nozzle protection part 311 grooves 312 Front end of nozzle protection part 313 Rear end of nozzle protection part 314 Side wall of nozzle protection part 320 supporting members 321 One end of a support member 322 Other end of support member 330 episodes of conflict 340 moving parts 400 Slider Type Protection 410 Nozzle Protection Parts 411 pop-up 412 Front end of nozzle protection part 413 Rear end of nozzle protection part 420 supporting members 421 Primary Arm 421A One end of the primary arm 421B Other end of primary arm 422 Second arm 422A One end of the second arm 422B Other end of second arm 430 episodes of conflict 441 primary moving parts 442 Second animated episode 443 Third animated episode 500 Syringe Pump 501A Initial level of syringe pump 501B Level II Syringe Pump 502A Syringe Pump Primary Wall 510 slot 520 retainer 530 movable walls 540 monitors 550 switches 560 processors 561 Memory 562 Pressure sensor 563 batteries 564 electric motors 570A, 570B Threaded Rod

Claims

Claims Our claims are as follows:

1. A syringe comprising: a syringe portion in contact with a hydrogen peroxide solution and the hydrogen peroxide solution within the syringe, wherein said portion is made of a cycloolefin polymer (COP) or a cycloolefin copolymer (COC), the syringe is suitable for pre-filling with the hydrogen peroxide solution, and the hydrogen peroxide solution comprises hydrogen peroxide and water.

2. A syringe according to claim 1, further comprising an additive.

3. A syringe according to claim 1 or 2, further comprising a nozzle on the needle-mounting portion of the syringe.

4. The syringe of claim 3, wherein the nozzle comprises a nozzle portion and an adapter portion connected to the syringe mounting portion, and the nozzle portion is a needle or spray nozzle.

5. The syringe according to claim 4, wherein the needle has a groove with an echogenic pattern on its outer surface.

6. A syringe according to claim 4 or 5, further comprising a guard, wherein the nozzle portion is covered by the guard.

7. The syringe of claim 6, wherein the guard comprises a support member, a nozzle guard portion connected to one end of the support member, and an engaging portion connected to the other end of the support member, and the nozzle guard portion comprises a space that can accommodate the nozzle portion.

8. The syringe according to claim 7, wherein the engaging portion includes a movable portion and is movably connected to the other end of the support portion via the movable portion.

9. A syringe according to claim 7 or 8, wherein the space is located on a side wall of the nozzle guard portion.

10. The syringe of claim 7, wherein the support member comprises a first arm, a second arm, a first movable portion, a second movable portion, and a third movable portion, one end of the first arm being movably connected to the nozzle guard portion via the movable portion, the other end of the first arm being movably connected to one end of the second arm via the second movable portion, and one end of the second arm being movably connected to the engaging portion via the third movable portion.

11. The syringe of claim 8, wherein the movable portion includes a rail portion connected to the nozzle guard portion and a rail retaining portion connected to the engaging portion, the rail retaining portion slidably retaining the rail portion.

12. The syringe according to claim 10 or 11, wherein the space is placed within the nozzle guard portion, and the nozzle guard portion has a hollow structure.

13. The syringe according to any one of claims 1 to 12, further comprising a syringe pump.

14. The syringe according to any one of claims 1 to 13, wherein the concentration of hydrogen peroxide in the hydrogen peroxide solution is 0.01 to 40% (w / v).

15. A kit comprising: a syringe according to claim 1 and a nozzle.

16. The kit according to claim 15, further comprising a shield for covering the nozzle portion.

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