Crystalline forms of pyrazolopyrimidine ester compounds and methods for preparing same

JP2025525738A5Pending Publication Date: 2026-06-15SHANGHAI MAIUS PHARM CO LTD
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Patent Information

Authority / Receiving Office
JP · JP
Patent Type
Applications
Current Assignee / Owner
SHANGHAI MAIUS PHARM CO LTD
Filing Date
2023-08-09
Publication Date
2026-06-15

AI Technical Summary

Technical Problem

The amorphous pyrazolopyrimidine ester compound used as a BTK inhibitor prodrug exhibits poor stability under normal storage conditions, decomposing significantly under heat and humidity, making it difficult to handle and store.

Method used

Development of a stable crystalline form (Form II) characterized by specific X-ray diffraction peaks and infrared absorption bands, allowing for long-term storage without special environmental controls.

Benefits of technology

The crystalline form II provides enhanced stability, enabling long-term storage and processing without temperature, light, or humidity concerns, with improved purity and reproducibility.

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Abstract

Formula (I): [Formula 1] A crystalline form of a pyrazolopyrimidine ester compound (Form II crystal) is provided, having the structure shown in TIFF2025525738000008.tif55145. This crystalline form is characterized by powder X-ray diffraction, differential scanning calorimetry, and infrared spectroscopy. A method for preparing the crystalline form of a pyrazolopyrimidine ester compound (Form II crystal) is also provided. This crystalline form can be stored for long periods of time without special requirements regarding temperature, light, humidity, or oxygen level characteristics, and has significant advantages in terms of stability. Furthermore, this preparation method has simple steps, good reproducibility, and excellent purity, and is expected to be widely applied.
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