Highly efficient and low-toxic cationic lipid compounds for extrahepatic targeting and compositions thereof
Novel cationic lipid compounds like YK-407, YK-401, YK-402, YK-403, and YK-422 address the limitations of existing lipid compositions by providing enhanced delivery efficiency, reduced toxicity, and targeted organ delivery, improving the safety and efficacy of nucleic acid delivery.
JP2025536412AActive Publication Date: 2025-11-05BEIJING YUEKANGKECHUANG PHARM TECH CO LTD
Patent Information
- Application Number
- JP2025524753
- Authority / Receiving Office
- JP · JP
- Patent Type
- Applications
- Current Assignee / Owner
- Priority Date
- 2023-02-08
- Filing Date
- 2023-04-10
- Publication Date
- 2025-11-05
- Estimated Expiration
- 2043-04-10
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Figure 2025536412000001_ABST
Abstract
The present disclosure provides a compound of formula (I), or an N-oxide, solvate, pharmaceutically acceptable salt, or stereoisomer thereof, which is a highly efficient and low-toxicity cationic lipid compound with extrahepatic targeting. Compositions comprising the aforementioned compounds and their use in delivering therapeutic or prophylactic agents are also provided. JPEG2025536412000103.jpg3940
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Citation Information
Patent Citations
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