Artificial blood vessel, and method for manufacturing an artificial blood vessel

Abstract

The present invention provides an artificial blood vessel having an inner surface that appropriately acts on blood flow, and a method for manufacturing an artificial blood vessel having an inner surface that appropriately acts on blood flow. [Solution] The artificial blood vessel comprises a tubular sheet that defines the space through which blood flows. The tubular sheet includes an ion-implanted layer as an inner layer. The main component of the ion-implanted layer is polytetrafluoroethylene. The inner circumferential surface of the ion-implanted layer is composed of a roughened surface mainly made of polytetrafluoroethylene.

Claims

1. It is equipped with a tubular sheet that defines the space through which blood flows, The tubular sheet includes an ion implantation layer as an inner layer, The main component of the ion implantation layer is polytetrafluoroethylene. The inner surface of the ion implantation layer is composed of a roughened surface mainly composed of polytetrafluoroethylene. Artificial blood vessel.

2. The ion-implanted layer is composed of a single layer in which elements implanted by ion implantation are mixed with the polytetrafluoroethylene. The artificial blood vessel according to claim 1.

3. At least a portion of the roughened surface, which is mainly composed of polytetrafluoroethylene, is exposed to the space through which the blood flows. The artificial blood vessel according to claim 1.

4. The tubular sheet is seamless. The artificial blood vessel according to any one of claims 1 to 3.

5. At least a portion of the outer surface of the tubular sheet is a second roughened surface. The artificial blood vessel according to any one of claims 1 to 3.

6. At least a portion of the outer surface of the tubular sheet is a non-roughened surface. The artificial blood vessel according to claim 5.

7. The inner circumferential surface of the ion implantation layer is supported with a drug. The artificial blood vessel according to any one of claims 1 to 3.

8. The aforementioned drug includes an anticoagulant. The artificial blood vessel according to claim 7.

9. A process for preparing a tubular sheet containing polytetrafluoroethylene, The process involves irradiating the polytetrafluoroethylene with an ion beam so that an ion implantation layer is formed in the tubular sheet, It is equipped with, The tubular sheet includes the ion implantation layer as an inner layer, The main component of the ion implantation layer is the polytetrafluoroethylene, The inner surface of the ion implantation layer is composed of a roughened surface mainly composed of polytetrafluoroethylene. A method for manufacturing artificial blood vessels.

10. The angle between the direction parallel to the longitudinal direction of the tubular sheet and the direction in which the ion beam is incident on the polytetrafluoroethylene is 45 degrees or more. A method for manufacturing an artificial blood vessel according to claim 9.

11. The process includes a step of inverting the cylindrical sheet so that the outer surface of the cylindrical sheet becomes the inner surface, The step of irradiating the polytetrafluoroethylene with the ion beam includes irradiating the outer surface of the cylindrical sheet with the ion beam. By inverting the cylindrical sheet, the outer surface irradiated with the ion beam becomes the inner surface. A method for manufacturing an artificial blood vessel according to claim 9 or 10.

12. After the step of irradiating the polytetrafluoroethylene with the ion beam is performed, a layer containing a drug is added to the surface of the ion implantation layer. A method for manufacturing an artificial blood vessel according to claim 9 or 10.

13. The method comprises the step of irradiating the outer surface of the cylindrical sheet with an ion beam so that a second ion implantation layer is formed on the cylindrical sheet, After the step of irradiating the outer surface of the cylindrical sheet with the ion beam, at least one of a bioadhesive and a coating to prevent blood leakage is applied to the surface of the second ion implantation layer. A method for manufacturing an artificial blood vessel according to claim 9 or 10.

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