Cosmetics or topical skin preparations

Abstract

The objective is to provide a cosmetic or topical skin preparation that exhibits excellent properties in suppressing the precipitation of ascorbic acid, ensuring the long-term stability of ascorbic acid, smoothing and spreading the skin with continuous use, and further providing superior moisturizing and non-greasy properties. [Solution] The following components (A) to (D); (A) Ascorbic acid 1-10% by mass (B) Glycerin 25-65% by mass (C) Polyhydric alcohols (excluding component (B)) (D) Monohydric lower alcohol 10-30% by mass A cosmetic or topical skin preparation containing an ingredient, with a water content of 10% by mass or less, or containing no water.

Description

[Technical Field]

[0001] This invention relates to cosmetics or topical skin preparations. [Background technology]

[0002] Ascorbic acid has been used in cosmetics (e.g., whitening cosmetics, anti-wrinkle cosmetics, anti-aging cosmetics, etc.) as a whitening, anti-wrinkle, and anti-aging ingredient due to its melanin production inhibitory effect, collagen production promoting effect, and antioxidant effect. However, because ascorbic acid is easily oxidized and decomposed, various technologies are being investigated to ensure its stable incorporation into cosmetics.

[0003] To date, technologies for topical preparations containing ascorbic acid have been investigated. For example, a topical composition containing at least one selected from the group consisting of ascorbic acid and salts of ascorbic acid, at least one selected from the group consisting of 3-O-ethyl ascorbic acid and salts of 3-O-ethyl ascorbic acid, diethylene glycol monoethyl ether, and a fragrance, with a polyethylene glycol content of less than 5% by mass (see, for example, Patent Document 1), and a topical skin preparation containing ascorbic acid, an oily gelling agent, and a polyhydric alcohol, with an ascorbic acid content of 0.5% by mass or more relative to the total mass of the topical skin preparation (see, for example, Patent Document 2), have been proposed. [Prior art documents] [Patent Documents]

[0004] [Patent Document 1] Japanese Patent Publication No. 2021-004207 [Patent Document 2] Japanese Patent Publication No. 2021-116270 [Overview of the Initiative] [Problems that the invention aims to solve]

[0005] However, the technology described in Patent Document 1 was insufficient in terms of the long-term stability of ascorbic acid and the smoothness of the skin with continued use, and the technology described in Patent Document 2 was insufficient in terms of moisturizing effect, spreadability, and the smoothness of the skin with continued use. As described above, there were still challenges in developing a cosmetic that ensures the long-term stability of ascorbic acid while providing good usability and a noticeable effect with continued use.

[0006] Therefore, the present invention aims to provide a cosmetic or topical skin preparation that is excellent in suppressing the precipitation of ascorbic acid, maintaining the long-term stability (residual rate) of ascorbic acid, smoothing the skin with repeated use, and spreading easily, and further possesses excellent moisturizing properties and a non-sticky feel. [Means for solving the problem]

[0007] In view of these circumstances, the present inventors conducted diligent studies and found that the above problems can be solved in a cosmetic or topical skin preparation containing a specific amount of ascorbic acid, a specific amount of glycerin, a polyhydric alcohol other than glycerin, and a specific amount of monohydric lower alcohol, with a water content of 10% by mass or less, or without water, and thus completed the present invention.

[0008] In other words, the present invention is [1] The following components (A) to (D); (A) Ascorbic acid 1-10% by mass (B) Glycerin 25-65% by mass (C) Polyhydric alcohols (excluding component (B)) (D) Monohydric lower alcohol 10-30% by mass It is a cosmetic or topical skin preparation containing [a specific ingredient] and having a water content of 10% by mass or less, or containing no water. [2] Preferably, the cosmetic or topical skin preparation described in [1] has an IOB value of component (C) of 1.5 to 3.5. [3] Preferably, the cosmetic or external preparation for skin according to [1] or [2] is such that the content mass ratio (B) / {(C)+(D)} of the component (B) to the total amount of the component (C) and the component (D) is 0.3 to 3. [4] Preferably, further, the cosmetic or external preparation for skin according to [1] or [2] contains a water-soluble compound in which δh in the Hansen solubility parameter of the component (E) is δh≦8 MPa. 0.5 [5] Preferably, the cosmetic or external preparation for skin according to [4] is such that the component (E) is at least one selected from the group consisting of polyoxybutylene polyoxyethylene polyoxypropylene glyceryl ether, polyoxyalkylene alkyl glucoside, and dicarboxylic acid ester. [6] Preferably, the cosmetic or external preparation for skin according to [1] or [2] is such that the content mass ratio (B) / (D) of the component (B) to the component (D) exceeds 1.1. [7] Preferably, the cosmetic or external preparation for skin according to [1] or [2] is for skin care use. [8] Further, the present invention is a method for producing a cosmetic or external preparation for skin according to [1] or [2], which is characterized in that at least the components (A) to (C) are heated and mixed, and then at least the component (D) is added and mixed and stirred.

Effects of the Invention

[0009] The cosmetic or external preparation for skin of the present invention is excellent in suppressing precipitation of ascorbic acid, stability over time (residual rate) of ascorbic acid, smoothness of the skin by combined use, and elongation. Further, it is excellent in moisturizing effect and non-stickiness.

Modes for Carrying Out the Invention

[0010] ​Preferred embodiments for carrying out the present invention will be described below. The embodiments described below are merely examples of representative embodiments of the present invention and should not be interpreted as narrowing the scope of the invention. Furthermore, unless otherwise specified, percentages in this specification are expressed in mass. The upper limit (less than or equal to) and lower limit (greater than or equal to) of each numerical range (~) can be arbitrarily combined as desired. In this specification, "X~Y" indicating a range includes X and Y and means "X or greater and Y or less". One or more components and examples may be selected and used from each group.

[0011] In this invention, the "IOB value" is a value determined based on the Organic Concept Diagram (Takashi Fujita, Prediction of Organic Compounds and the Organic Concept Diagram, Chemistry Vol. 11, No. 10 (1957) 719-715). More specifically, in this Organic Concept Diagram, the degree of physical properties of a compound is defined and expressed as follows: the degree of properties due to van der Waals forces is called "organic," and the degree of properties due to electrical affinity is called "inorganic." The IOB value is an index that shows the balance between inorganic and organic properties, and is expressed as IOB value = inorganic value / organic value. Compounds with a larger IOB value are said to exhibit higher hydrophilicity and polarity.

[0012] The present invention relates to the following components (A) to (D); (A) Ascorbic acid 1-10% by mass (B) Glycerin 25-65% by mass (C) Polyhydric alcohols (excluding component (B)) (D) Monohydric lower alcohol 10-30% by mass A cosmetic or topical skin preparation can be provided that contains [a certain substance] and has a water content of 10% by mass or less, or does not contain water.

[0013] [Ingredient (A): Ascorbic acid]

[0014] The component (B) ascorbic acid used in the present invention may be the D-isomer, L-isomer, or DL-isomer, but the L-isomer (L-ascorbic acid) is preferred. Commercially available ascorbic acid can be used. Examples of commercially available ascorbic acid include ultrafine ascorbic acid powder (component name: L-ascorbic acid: manufactured by DSM).

[0015] The content of component (A) used in the present invention is, at a lower limit, 1% by mass (hereinafter simply abbreviated as "%)" or more, preferably 1.5% or more, and more preferably 2% or more, from the viewpoint of suitably exhibiting the effects of ascorbic acid such as skin smoothness with continuous use. At an upper limit, from the viewpoint of suppressing ascorbic acid precipitation, the long-term stability of ascorbic acid, skin smoothness with continuous use, and good spreadability, it is 10% or less, preferably 8% or less, and more preferably 6% or less. Furthermore, the content of component (A) is 1 to 10%, preferably 1 to 8%, more preferably 1.5 to 8%, even more preferably 2 to 8%, and even more preferably 2 to 6%. Within this range, it is more preferable because it is excellent in suppressing ascorbic acid precipitation, the long-term stability of ascorbic acid, skin smoothness with continuous use, and good spreadability. If the content of component (A) is less than 1%, satisfactory effects of ascorbic acid may not be obtained, and if it exceeds 10%, concerns may arise regarding the inhibition of ascorbic acid precipitation and the long-term stability of ascorbic acid, resulting in poor spreadability.

[0016] [Ingredient (B): Glycerin]

[0017] The component (B) glycerin used in the present invention is a type of trihydric alcohol, also known as glycerol (HO-CH2-CH(OH)-CH2-OH)), and may be a commercially available product or one produced by a known manufacturing method.

[0018] The lower limit of the content of component (B) used in the present invention is 25% or more, preferably 30% or more, more preferably 35% or more, and even more preferably 40% or more, from the viewpoint of suppressing the precipitation of ascorbic acid, the long-term stability of ascorbic acid, the smoothness of the skin with continuous use, and the moisturizing effect. The upper limit is 65% or less, preferably 60% or less, and even more preferably 55% or less, from the viewpoint of not being sticky and having good spreadability. Furthermore, the content of component (B) is 25-65%, preferably 30-65%, more preferably 35-60%, even more preferably 40-60%, and even more preferably 40-55%. Within this range, the effects of the present invention are suitably exhibited, and therefore it is more preferable.

[0019] [Ingredient (C): Polyhydric alcohol]

[0020] The polyhydric alcohol component (C) used in the present invention is obtained by substituting hydrogen atoms of a chain hydrocarbon with hydroxyl groups, and is an alcohol having two or more hydroxyl groups, excluding component (B). The chain hydrocarbon includes both straight-chain and branched hydrocarbons. Examples of component (C) include propylene glycol (1,2-propanediol), dipropylene glycol, 1,3-propanediol, diglycerin, polyglycerin-3, 1,3-butylene glycol, 1,2-pentanediol, isoprene glycol, PEG-8 (average molecular weight 400 (average molecular weight 380-420)), and one or more of these can be selected and used as needed. The average molecular weight of "PEG-8" is measured in accordance with the measurement method (titration method) described in the "Polyethylene Glycol 400" section of the "Standards for Quasi-Drug Raw Materials 2021" of the Pharmaceuticals and Medical Devices Agency (PMDA). Furthermore, PEG-8 is known by the INCI name "PEG-8" and the common chemical name "polyethylene glycol 400".

[0021] In the present invention, from the viewpoint of non-stickiness and good spreadability, the IOB value of component (C) is preferably 1.5 to 3.5, more preferably 1.5 to 3.3, and even more preferably 1.8 to 3.3. Specifically, examples include propylene glycol (1,2-propanediol) (IOB value = 3.3), dipropylene glycol (IOB value = 1.8), 1,3-propanediol (IOB value = 3.3), diglycerin (IOB value = 3.5), polyglycerin-3 (IOB value = 3.0), 1,3-butylene glycol (IOB value = 2.5), 1,2-pentanediol (IOB value = 2.0), isoprene glycol (IOB value = 2.2), and PEG-8 (average molecular weight 400) (IOB value = 2.3), and one or more of each can be selected and used as needed. In the present invention, from the viewpoint of non-stickiness and good spreadability, it is preferable that the material be a polyhydric alcohol other than a sugar alcohol, and more preferably one or more selected from dihydric glycols and polyethylene glycol that is liquid at 25°C. Specifically, at least one selected from propylene glycol (IOB value = 3.3), dipropylene glycol (IOB value = 1.8), 1,3-butylene glycol (IOB value = 2.5), isoprene glycol (IOB value = 2.2), and PEG-8 (average molecular weight 400) (IOB value = 2.3) is even more preferable. Here, polyethylene glycol that is liquid at 25°C refers to polyethylene glycol that exhibits fluidity at 25°C.

[0022] The content of component (C) used in the present invention is not particularly limited, but from the viewpoint of non-stickiness and good spreadability, a lower limit of 8% or more is preferred, 10% or more is more preferred, 12% or more is even more preferred, and 15% or more is even more preferred. From the viewpoint of skin smoothness and moisturizing feeling with continuous use, an upper limit of 50% or less is preferred, 40% or less is more preferred, 35% or less is even more preferred, and 30% or less is even more preferred. Furthermore, the content of component (C) is preferably 8-50%, more preferably 10-40%, even more preferably 10-35%, even more preferably 12-30%, and particularly preferably 15-30%. Within this range, the effects of the present invention are suitably exhibited, and therefore it is more preferred.

[0023] In the present invention, the mass ratio of the total amount of component (B) and component (C) to component (A) {(B)+(C)} / (A) is preferably 6 or more, more preferably 6.5 or more, even more preferably 7 or more, even more preferably 8 or more, and particularly preferably 10 or more, from the viewpoint of suppressing the precipitation of ascorbic acid, the long-term stability of ascorbic acid, skin smoothness with continuous use, and good spreadability. As an upper limit, from the viewpoint of the effects of ascorbic acid such as skin smoothness with continuous use, it is preferably 80 or less, more preferably 75 or less, even more preferably 70 or less, even more preferably 60 or less, even more preferably 50 or less, and particularly preferably 40 or less. Furthermore, the mass ratio of the total amount of component (B) and component (C) to component (A) is preferably 6 to 80, more preferably 6.5 to 75, even more preferably 7 to 70, even more preferably 8 to 60, even more preferably 10 to 50, and particularly preferably 10 to 40. Within this range, it is preferable because it offers superior inhibition of ascorbic acid precipitation, long-term stability of ascorbic acid, and smoothness and spreadability of the skin with continued use.

[0024] [Component (D): Monohydric lower alcohol]

[0025] The monohydric lower alcohol (D) used in the present invention is not particularly limited as long as it is commonly used in cosmetics or topical skin preparations, but is preferably a C1-C4 (preferably C1-C3) lower alcohol, for example, lower alcohols such as ethanol, and one or more selected from these can be used, but in the present invention, ethanol is preferred from the viewpoint of non-stickiness and good spreadability.

[0026] The lower limit of the content of component (D) used in the present invention is 10% or more, preferably 12% or more, and more preferably 15% or more, from the viewpoint of non-stickiness and good spreadability. The upper limit is 30% or less, preferably 28% or less, and more preferably 25% or less, from the viewpoint of suppressing the precipitation of ascorbic acid, the long-term stability of ascorbic acid, skin smoothness with continuous use, and moisturizing effect. Furthermore, the content of component (D) is 10-30%, preferably 12-28%, and more preferably 15-25%. Within this range, the effects of the present invention are suitably exhibited, and therefore it is more preferable.

[0027] In the present invention, the mass ratio (B) / (D) of component (B) to component (D) is preferably greater than 1.1, more preferably 1.2 or greater, even more preferably 1.3 or greater, and even more preferably 1.5 or greater, from the viewpoint of suppressing the precipitation of ascorbic acid, the long-term stability of ascorbic acid, the smoothness of the skin with continuous use, and the moisturizing effect. As an upper limit, it is preferably 7 or less, more preferably 6 or less, and even more preferably 5 or less, from the viewpoint of non-stickiness and good spreadability. Furthermore, the mass ratio (B) / (D) is preferably greater than 1.1 and 7 or less, more preferably 1.2 to 6, even more preferably 1.3 to 6, and even more preferably 1.5 to 5. Within this range, the effects of the present invention are suitably exhibited, and therefore it is more preferable.

[0028] In the present invention, the mass ratio (B) / {(C)+(D)} of component (B) to the total amount of component (C) and component (D) is preferably 0.3 or higher, more preferably 0.35 or higher, even more preferably 0.4 or higher, even more preferably 0.6 or higher, and particularly preferably 0.8 or higher, from the viewpoint of suppressing the precipitation of ascorbic acid, the long-term stability of ascorbic acid, the smoothness of the skin with continuous use, and the feeling of moisturizing effect. As an upper limit, it is preferably 3 or less, more preferably 2.5 or less, and even more preferably 2 or less, from the viewpoint of not being sticky and having good spreadability. Furthermore, the mass ratio (B) / {(C)+(D)} is preferably 0.3 to 3, more preferably 0.35 to 3, even more preferably 0.4 to 2.5, even more preferably 0.6 to 2, and particularly preferably 0.8 to 2. Within this range, the effects of the present invention are suitably exhibited, and therefore it is more preferable.

[0029] [Component (E) Hansen solubility parameter δh is δh ≤ 8 MPa] 0.5 [Water-soluble compounds]

[0030] In this invention, the component (E) Hansen solubility parameter δh is further defined as δh ≤ 8 MPa. 0.5 It is more preferable to contain a water-soluble compound. Among water-soluble compounds, it is more preferable to contain component (E), which is a compound with a certain degree of hydrophobicity, as it has good affinity with the present invention, which has a water content of 10% or less, and while it can suitably exhibit skin smoothness and moisturizing effect with continuous use, it can further improve non-stickiness and spreadability. The component (E) used in this invention has a Hansen solubility parameter δh such that δh ≤ 8 MPa 0.5 It is a water-soluble compound. The Hansen solubility parameter (HSP) is a value published by Charles M. Hansen in 1967 that is used to predict the solubility of a substance, and consists of the following three parameters (unit: MPa) 0.5 It is composed of ). δd: Energy due to intermolecular dispersion forces δp: Energy due to intermolecular dipole interaction δh: Energy due to intermolecular hydrogen bonds

[0031] These three parameters can be regarded as coordinates in three-dimensional space (Hansen space). When the HSPs of two substances are placed in Hansen space, the closer the distance between the two points, the easier they are to dissolve in each other, indicating that it can be used as an index of the affinity between substances. The HSP of each substance can be obtained by using software for personal computers such as "HSPiP: Hansen Solubility Parameters in Practice" (specifically, "HSPiP: Hansen Solubility Parameters in Practice Ver.5.4.05").

[0032] The distance Ra (unit: MPa 0.5 ) of the Hansen solubility parameter can be obtained by the following formula (Equation 1) when the coordinates of the HSP of component X are (δdX, δpX, δhX) and the coordinates of the HSP of component Y are (δdY, δpY, δhY). Ra can also be calculated by the Ra calculation function of HSPiP.

[0033]

Equation

[0034] Component (E) of the present invention is a water-soluble compound in which δh in the Hansen solubility parameter is δh ≦ 8 MPa 0.5 and preferably δh ≦ 7.5 MPa 0.5 and more preferably δh ≦ 7 MPa 0.5 .

[0035] Examples of the water-soluble compound in which δh in the Hansen solubility parameter of component (E) of the present invention is δh ≦ 8 MPa 0.5 include polyoxyalkylene monohydric alcohol ethers, polyoxyalkylene polyhydric alcohol ethers, dicarboxylic acid esters, etc. In the present invention, it is preferable to use polyoxyalkylene polyhydric alcohol ethers and dicarboxylic acid esters. Examples of polyoxyalkylene polyhydric alcohol ethers include polyoxyalkylene glycerin, polyoxyalkylene alkyl glucoside (such as polyoxypropylene alkyl glucoside and polyoxyethylene alkyl glucoside), polyoxyalkylene sorbitol, polyoxyalkylene erythritol ether, polyoxyalkylene pentaerythritol ether, polyoxyalkylene diglyceryl ether, polyoxyalkylene trimethylolpropane, polyoxypropylene glycol, polyoxyethylene polyoxypropylene glycol, polyoxybutylene polyoxyethylene polyoxypropylene glyceryl ether, polyoxyalkylene xylitol, and polyoxy Examples include polyoxyalkylene pentaerythritol, polyoxyalkylene inositol, polyoxyalkylene sucrose ether, polyoxyalkylene trehalose ether, and polyoxyalkylene maltitol ether. Preferably, it is one or more selected from the group consisting of polyoxyalkylene glycerin, polyoxyalkylene alkyl glucoside, polyoxyalkylene diglyceryl ether, and polyoxybutylene polyoxyethylene polyoxypropylene glyceryl ether. More preferably, it is one or more selected from the group consisting of polyoxybutylene polyoxyethylene polyoxypropylene glyceryl ether and polyoxyalkylene alkyl glucoside. Specifically, PEG / PPG / polybutylene glycol-8 / 5 / 3 glycerin (polyoxybutylene polyoxyethylene polyoxypropylene glyceryl ether) (δh=5.2MPa) 0.5 ), PPG-10 methyl glucose (polyoxyalkylene alkyl glucoside, polyoxypropylene alkyl glucoside) (δh=0.1MPa) 0.5 ), Methyl Gluceth-10 (Polyoxyalkylene alkyl glucoside, Polyoxyethylene alkyl glucoside) (δh=6.0MPa) 0.5 Examples include: Dicarboxylic acid esters are diesters formed by condensing a divalent carboxylic acid with a hydroxyl group such as a glycol, glycol ether, or alcohol, and can be used without particular limitations as long as they are commonly used in cosmetics. Specifically, cyclohexane-1,4-dicarboxylic acid bisethoxydiglycol (δh=6.6MPa) 0.5 Examples include:

[0036] Furthermore, a water-soluble compound is defined as a compound whose solubility in 100g of water at 20°C is 3g / 100g or higher.

[0037] Component (E) of the present invention further has a Hansen solubility parameter δp < 9 MPa 0.5 Preferably, the following conditions apply: δp ≤ 8.5 MPa 0.5 It is more preferable that δp ≤ 8MPa 0.5 It is even more preferable if it is such a compound. Examples of such water-soluble compounds include PEG / PPG / polybutylene glycol-8 / 5 / 3 glycerin (δp=7.9MPa). 0.5 ), PPG-10 methyl glucose (δp=7.8MPa) 0.5 ), Methyl Gluceth-10 (δp=8.1MPa) 0.5 ), cyclohexane-1,4-dicarboxylic acid bisethoxydiglycol (δp=5.1MPa) 0.5 Examples include:

[0038] Component (E) of the present invention further has a Hansen solubility parameter δd of 10 ≤ δd ≤ 20 MPa. 0.5 It is preferable that the compound be such. Examples of such water-soluble compounds include PEG / PPG / polybutylene glycol-8 / 5 / 3 glycerin (δd=15MPa). 0.5 ), PPG-10 methyl glucose (δd=16MPa) 0.5 ), Methyl Gluceth-10 (δd=15.5MPa) 0.5 ), cyclohexane-1,4-dicarboxylic acid bisethoxydiglycol (δd=16.5MPa) 0.5 Examples include:

[0039] The content of component (E) used in the present invention is not particularly limited, but as a lower limit, from the viewpoint of exhibiting suitable skin smoothness and moisturizing effect with continuous use, as well as being non-greasy and easy to spread, it is preferably 0.1% or more, more preferably 0.5% or more, even more preferably 1% or more, and even more preferably 3% or more. As an upper limit, from the viewpoint of suppressing the precipitation of ascorbic acid and the long-term stability of ascorbic acid, it is preferably 20% or less, more preferably 15% or less, even more preferably 10% or less, and even more preferably 8% or less. Furthermore, the content of component (E) is preferably 0.1 to 20%, more preferably 0.5 to 15%, even more preferably 1 to 10%, and even more preferably 3 to 8%. Within this range, it is more preferable because it is possible to further improve non-greasyness and easy spread while exhibiting suitable skin smoothness and moisturizing effect with continuous use, as well as suppressing the precipitation of ascorbic acid and the long-term stability of ascorbic acid.

[0040] The cosmetic or topical skin preparation of the present invention has a water content of 10% or less, or contains no water. Here, the water in the present invention is not particularly limited as long as it is water that is normally used in cosmetics, and examples include tap water, purified water, hot spring water, deep sea water, or steam distilled water derived from plants such as lavender water, rose water, orange blossom water, damask rose flower water, witch hazel water, and orange blossom water, and one or more of these may be used in combination as needed. Furthermore, the water may be one or more selected from tap water, purified water, hot spring water, and deep sea water, or it may be steam distilled water derived from plants alone, or it may be a combination of one or more selected from tap water, purified water, hot spring water, and deep sea water and steam distilled water derived from plants.

[0041] In the present invention, the water content is preferably 10% or less as an upper limit, more preferably 8% or less, more preferably 6% or less, and particularly preferably 5% or less, from the viewpoint of the long-term stability of ascorbic acid, skin smoothness with continuous use, and moisturizing effect. As a lower limit, it is preferably no water (0%), more preferably more than 0%, more preferably 1% or more, and even more preferably 3% or more, from the viewpoint of non-stickiness and good spreadability. Furthermore, the water content is 10% or less or no water, preferably more than 0% and 10% or less, more preferably 1-10%, even more preferably 1-8%, even more preferably 3-6%, and particularly preferably 3-5% or less. Within this range, the effects of the present invention are suitably exhibited, and therefore more preferable. When the water content exceeds 10%, there are concerns about the precipitation of ascorbic acid and a decrease in its remaining content, and the stability of ascorbic acid may be insufficient.

[0042] In addition to the essential components described above, the cosmetic or topical skin preparation of the present invention may contain, as necessary, components commonly used in ordinary cosmetics or topical skin preparations, within a quantitative and qualitative range that does not impair the effects of the present invention. For example, it may contain surfactants, water-soluble polymers, oil-soluble polymers, oils, powders, UV absorbers, antioxidants, fragrances, preservatives, pH adjusters, cooling agents, beauty ingredients, etc.

[0043] The cosmetic or topical skin preparation of the present invention is preferably substantially free of oils from the viewpoint of stability and spreadability as a formulation. The oils are not particularly limited as long as they are commonly used in cosmetics or topical skin preparations, and include higher alcohols, hydrocarbon oils, ester oils, fats and oils, and silicones. For example, higher alcohols such as lauryl alcohol, myristyl alcohol, palmityl alcohol, stearyl alcohol, behenyl alcohol, hexadecyl alcohol, oleyl alcohol, isostearyl alcohol, hexyldodecanol, octyldodecanol, cetostearyl alcohol, 2-decyltetradesinol, cholesterol, phytosterol, sitosterol, lanosterol, monostearyl glycerin ether (batyl alcohol) (for example, with a preferred lower limit of 6 or more carbon atoms or 12 or more carbon atoms, or a preferred upper limit of 30 or 22 carbon atoms);Ozokerite, squalane, squalene, ceresin, paraffin, paraffin wax, liquid paraffin, pristane, polyisobutylene, microcrystalline wax, petrolatum and other hydrocarbons, diisobutyl adipate, 2-hexyldecyl adipate, di-2-heptylundecyl adipate, N-alkyl glycol monoisostearate, isocetyl isostearate, trimethylolpropane triisostearate, ethylene glycol di-2-ethylhexanoate, cetyl 2-ethylhexanoate, trimethylolpropane tri-2-ethylhexanoate, pentaerythritol tetra-2-ethylhexanoate, cetyl octanoate, octyldodecyl gum ester, oleyl oleate, octyldodecyl oleate, decyl oleate, neopentyl dicaprate Ester oils such as glycol, triethyl citrate, 2-ethylhexyl succinate, isocetyl stearate, butyl stearate, diisopropyl sebacate, di-2-ethylhexyl sebacate, cetyl lactate, myristyl lactate, isopropyl palmitate, 2-ethylhexyl palmitate, 2-hexyldecyl palmitate, 2-heptylundecyl palmitate, cholesteryl 12-hydroxystearate, dipentaerythritol fatty acid ester, isopropyl myristate, octyldodecyl myristate, 2-hexyldecyl myristate, myristyl myristate, hexyldecyl dimethyloctanoate, ethyl laurate, hexyl laurate, and diisostearyl malate (e.g., organic acid esters, fatty acid esters, polyhydric alcohol esters, etc.);Waxes such as beeswax, carnauba wax, candelilla wax, and whale wax; vegetable oils such as palm oil, palm kernel oil, olive oil, safflower oil, soybean oil, and cottonseed oil; animal oils such as beef tallow, beef tallow, beef bone tallow, hardened beef tallow, hardened oil, turtle oil, pork fat, horse fat, mink oil, liver oil, and egg yolk oil; lanolin derivatives such as lanolin, liquid lanolin, reduced lanolin, lanolin alcohol, hard lanolin, lanolin acetate, and isopropyl lanolin fatty acid; low-molecular-weight dimethylpolysiloxane, high-molecular-weight dimethylpolysiloxane, methylphenylpolysiloxane, decameth Examples include cyclopentasiloxane, octamethylcyclotetrasiloxane, polyether-modified polysiloxane, polyoxyalkylene / alkylmethylpolysiloxane / methylpolysiloxane copolymer, alkoxy-modified polysiloxane, alkyl-modified polysiloxane, cross-linked organopolysiloxane, fluorine-modified polysiloxane, amino-modified polysiloxane, glycerin-modified polysiloxane, higher alkoxy-modified silicone, higher fatty acid-modified silicone, silicone resin, silicone rubber, silicone resin, and other silicone-based materials. Here, "substantially absent" means that the content is 2% or less, preferably 1% or less, more preferably 0.5% or less, and even more preferably 0.3% or less, but may also be 0.2% or less, 0.1% or less, or 0% (not present) as needed. Furthermore, "substantially absent" here means preferably not containing 2% or more, more preferably not containing 1% or more, even more preferably not containing 0.5% or more, and even more preferably not containing 0.3% or more.

[0044] Examples of surfactants include nonionic surfactants, anionic surfactants, cationic surfactants, and amphoteric surfactants. For example, these include glycerin fatty acid esters and their alkylene glycol adducts, polyglycerin fatty acid esters and their alkylene glycol adducts, sorbitan fatty acid esters and their alkylene glycol adducts, sucrose fatty acid esters, polyoxyethylene hydrogenated castor oil, polyoxyalkylene alkyl copolymerized organopolysiloxanes, polyether-modified organopolysiloxanes, phospholipids, etc., and one or more of these can be used.

[0045] The cosmetic or topical skin preparation of the present invention preferably contains substantially no cationic surfactants in order to obtain a non-greasy feel and a high level of effectiveness with continuous use. The cationic surfactant is not particularly limited as long as it is one that is normally used in cosmetics, etc. For example, monoammonium lauryltrimethylammonium chloride, lauryltrimethylammonium bromide, lauroxypropyltrimethylammonium chloride, myristyltrimethylammonium chloride, myristyltrimethylammonium bromide, myristylpropyltrimethylammonium chloride, palmityltrimethylammonium chloride, palmityltrimethylammonium bromide, palmitoylpropyltrimethylammonium chloride, stearyltrimethylammonium chloride, stearyltrimethylammonium bromide, stearoxypropyltrimethylammonium chloride, behenyltrimethylammonium chloride, behenyltrimethylammonium bromide, behenylpropyltrimethylammonium chloride, behenylPGtrimonium chloride, etc. Examples include dialkyldimethylammonium type surfactants such as quiltrimethylammonium type surfactants, dilauryldimethylammonium chloride, dilauryldimethylammonium bromide, dilauroxypropyldimethylammonium chloride, dimyristyldimethylammonium chloride, dimyristyldimethylammonium bromide, dipalmityldimethylammonium chloride, dipalmityldimethylammonium bromide, distearyldimethylammonium chloride, distearyldimethylammonium bromide, dibehenyldimethylammonium chloride, and dibehenyldimethylammonium bromide, as well as dicocoylethyl hydroxyethylmonium type surfactants such as dicocoylethyl hydroxyethylmonium chloride, dicocoylethyl hydroxyethylmonium methosulfate, and dicocoylethyl hydroxyethylmonium methophosphate. Here, "substantially absent" means that the content is 1% or less, preferably 0.5% or less, more preferably 0.3% or less, even more preferably 0.1% or less, and particularly preferably 0% (not present). Furthermore, "substantially absent" here means preferably 1% or more, more preferably 0.5% or more, even more preferably 0.3% or more, even more preferably 0.1% or more, and even more preferably 0%.

[0046] Examples of UV absorbers include benzophenone-based, para-aminobenzoic acid-based, cinnamic acid-based, salicylic acid-based, 4-tert-butyl-4'-methoxydibenzoylmethane, and oxybenzone.

[0047] Examples of antioxidants include α-tocopherol, dibutylhydroxytoluene, and butylhydroxyanisole.

[0048] Examples of preservatives include benzoic acid, salicylic acid, carbolic acid, sorbic acid, parahydroxybenzoic acid esters, benzalkonium chloride, chlorhexidine chloride, trichlorocarbanilide, photosensitizer, and phenoxyethanol.

[0049] The present invention may contain one or more of glycyrrhetinic acid, glycyrrhizic acid, or glycyrrhizinate (e.g., alkali metal salts such as potassium salts and sodium salts; ammonium salts, etc.), or a combination of two or more of these, but may not contain them substantially. Examples of glycyrrhizinate include dipotassium glycyrrhizinate, monoammonium glycyrrhizinate, disodium glycyrrhizinate, and trisodium glycyrrhizinate, and one of these (e.g., dipotassium glycyrrhizinate) may be appropriately selected to be substantially absent. Here, substantially absent means that the content is 1% or less, preferably 0.5% or less, more preferably 0.3% or 0.2% or less, even more preferably 0.1% or less, particularly preferably 0% (not present), preferably 1% or more absent, more preferably 0.5% or more absent, even more preferably 0.3% or 0.2% or more absent, even more preferably 0.1% or more absent, or preferably 0% absent.

[0050] The powder components are not particularly limited in terms of shape (spherical, plate-shaped, spindle-shaped, needle-shaped, etc.), particle size, particle structure (porous, non-porous, etc.), etc., and include inorganic powders, lustrous powders, organic powders, and composite powders. Specifically, inorganic powders such as titanium dioxide, zinc oxide, aluminum oxide, cerium oxide, magnesium oxide, zirconium oxide, magnesium carbonate, calcium carbonate, chromium oxide, chromium hydroxide, aluminum silicate, magnesium silicate, aluminum magnesium silicate, mica, synthetic mica, synthetic sericite, sericite, talc, kaolin, silicon carbide, barium sulfate, and boron nitride; bismuth oxychloride, titanium mica, anhydrous silica-coated titanium mica, titanium dioxide-coated glass powder, titanium dioxide / iron oxide-coated glass powder; and titanium dioxide / anhydrous silica-coated glass powder. Examples include glittering powders such as coated glass powder and aluminum powder, organic powders such as N-acyllysine and nylon, composite powders such as fine-particle titanium oxide-coated titanium mica, fine-particle zinc oxide-coated titanium mica, barium sulfate-coated titanium mica, titanium oxide-containing silicon dioxide, and zinc oxide-containing silicon dioxide, as well as polyethylene terephthalate-aluminum-epoxy laminated powder, polyethylene terephthalate-polyolefin laminated film powder, and polyethylene terephthalate-polymethyl methacrylate laminated film powder, and one or more of these can be used. Furthermore, these powders may be composites of one or more of these, and may be surface-treated by known methods using fluorine compounds, silicone-based oils, metal soaps, waxes, surfactants, oils and fats, hydrocarbons, etc.

[0051] The properties of the cosmetic or topical skin preparation of the present invention are not particularly limited, but include liquid, cream, semi-solid, mousse, etc. Among these, a liquid form is preferred from the viewpoint of ease of use and spreadability.

[0052] From the viewpoint of ease of spreadability and other factors, the viscosity of the cosmetic or topical skin preparation of the present invention is preferably 500 mPa·s or less, more preferably 400 mPa·s or less, and even more preferably 200 mPa·s or less, measured at 25°C using a B-type viscometer, rotor No. 2, 6 rpm, and an average value over 1 minute.

[0053] The cosmetic composition of the present invention is not particularly limited, but may be in any one or more forms selected from the following: hair cosmetics such as hair cosmetics, eyelash cosmetics, and eyebrow cosmetics; skincare cosmetics such as lotions, creams, toners, serums, packs, eye creams, balms, massage cosmetics, hand creams, body creams, all-in-one gels, sunscreens, and impregnating masks; makeup cosmetics such as makeup bases, BB creams, foundations, blushes, and lipsticks; topical skin preparations; dispersions, ointments, liquids, aerosols, patches, poultices, liniments, etc. Furthermore, the cosmetic composition of the present invention may be applied to topical skin preparations and compositions such as pharmaceuticals, quasi-drugs, skincare products, and skin protectants, or it may be either a cosmetic composition or a topical skin preparation. In addition, compositions containing at least ascorbic acid in the present invention may be applied for whitening, anti-wrinkle, or anti-aging purposes.

[0054] The cosmetic or topical skin preparation of the present invention is more preferably for skincare use, and even more preferably for leave-on skincare use, from the viewpoint of moisturizing effect, non-greasy feel, and smooth skin with continued use.

[0055] The method for producing the cosmetic or topical skin preparation of the present invention is not particularly limited and can be produced by known methods. For example, it can be obtained by mixing components (A) to (D) or components (A) to (E) and other components as appropriate (e.g., water), and then filling into a container. The mixing may be done under appropriate heating (e.g., 70 to 90°C). In the present invention, from the viewpoint of suppressing the precipitation of ascorbic acid, the long-term stability of ascorbic acid, non-stickiness, and good spreadability, it is more preferable to (1) heat and mix at least components (A) to (C), and (2) add and mix at least component (D) after cooling to room temperature. Component (E) may be in either (1) or (2), but it is preferable to incorporate it into (1) before heating. Water is not required to be included, but if water is included, it may be in either (1) or (2) or both, but it is preferable to mix when at least (A) to (C) or (A) to (C)(E) are included. Furthermore, the manufacturing method of the present invention preferably includes (i) heating and mixing at least the above components (A) to (C), and adding at least the above component (D) to these mixtures and mixing and stirring them.

[0056] The container for filling the cosmetic or topical skin preparation of the present invention is not particularly limited, but bottle containers, dispenser containers, etc. are preferred, and among these, pointed-cap bottle containers are more preferred because they have good spreadability, can be used partially, and are suitable for continuous use. Specifically, examples include pointed-cap containers (cap: product number 27mm pointed cap, manufactured by Takemoto Container Co., Ltd., bottle: product number AO-100, manufactured by Takemoto Container Co., Ltd.).

[0057] Furthermore, the present invention may also adopt the following configuration. Moreover, the present invention is not limited to the cosmetics or topical skin preparations and methods for producing the same as described above, but may also be an invention of another aspect or another embodiment derived from this entire specification. In the following configuration, explanations that are redundant with each technical feature, each configuration, each definition, each term, each method, etc. of the components (e.g., components (A) to (D), component (E), etc.) described above may be omitted as appropriate. Furthermore, each component, each technology, or each embodiment described above can be applied to any of them, and each technical feature, etc. can be appropriately adopted in each technology or each embodiment, etc. Also, in this specification, "comprise" may be changed to "consist essentially of" and "consist of" as needed.

[0058] <1> The following components (A) to (D); (A) Ascorbic acid 1-10% by mass (B) Glycerin 25-65% by mass (C) Polyhydric alcohols (excluding component (B)) (D) Monohydric lower alcohol 10-30% by mass It is a cosmetic or topical skin preparation containing [a specific ingredient] and having a water content of 10% by mass or less, or containing no water. <2> The cosmetic or topical skin preparation described in <1> has an IOB value of 1.5 to 3.5 for component (C). <3> The cosmetic or topical skin preparation described in <1> or <2> is wherein the mass ratio of component (B) to the total amount of component (C) and component (D) (B) / {(C)+(D)} is 0.3 to 3. <4> Furthermore, the δh value in the Hansen solubility parameter for component (E) is δh ≤ 8 MPa. 0.5 A cosmetic or topical skin preparation containing a water-soluble compound as described in any one of (1) to (3). <5> The cosmetic or topical skin preparation according to <4> is wherein component (E) is at least one selected from the group consisting of polyoxybutylene polyoxyethylene polyoxypropylene glyceryl ether, polyoxyalkylene alkyl glucoside, and dicarboxylic acid ester. <6> The cosmetic or topical skin preparation described in any one of <1> to <5> is wherein the mass ratio (B) / (D) of component (B) to component (D) is greater than 1.1. <7> The cosmetic or topical skin preparation described in <6> is wherein the mass ratio (B) / (D) of component (B) to component (D) is greater than 1.1 and 7 or less. <8> A cosmetic or topical skin preparation described in any one of (1) to (7), which substantially does not contain cationic surfactants. <9> A cosmetic or topical skin preparation described in any one of (1) to (8), which substantially does not contain oils. <10> A cosmetic or topical skin preparation described in any one of the following (1) to (9) for skincare purposes. <11> This is a cosmetic or topical skin preparation described in any one of (1) to (10), which is used by filling it into a pointed-cap bottle container. <12> (i) A method for producing a cosmetic or topical skin preparation according to any one of <1> to <11>, characterized by heating and mixing the components (A) to (C) or (ii) the components (A) to (C) and component (E), then adding component (D), and mixing and stirring.

[0059] <13> The present invention may also provide, from this whole specification, the following other aspects of the invention: (1) A method for inhibiting the precipitation of ascorbic acid and / or stabilizing ascorbic acid over time (e.g., improving or enhancing the residual rate) in a composition (preferably a cosmetic or topical skin preparation) containing at least the above component (A) by using components (B) to (C) or components (B) to (D). Such use may be by adding, blending, or including in the composition. Furthermore, by using at least a combination of components (B) to (C) or components (B) to (D), (1) can provide a composition that, in addition to inhibiting the precipitation of ascorbic acid and improving the stability of ascorbic acid over time (residual rate), provides excellent smoothness and spreadability of the skin with repeated use when applied to the skin, and also provides a composition that is excellent in moisturizing effect and non-stickiness. (2) In the manufacture of a composition containing component (A) (preferably a cosmetic or topical skin preparation), or for use in such manufacture, components (B) to (C) or components (B) to (D) or the same may be used. Furthermore, (2) may be in the manufacture of a cosmetic or topical skin preparation described in any one of (1) to (11), or for use in such manufacture, components (A) to (C) or components (A) to (D) or the same may be used. In addition, (2) may use any necessary components as appropriate. (3) In addition, components (B) to (C) or components (B) to (D) or their use may be used for the purpose of suppressing the precipitation of ascorbic acid in a composition containing component (A), or for the purpose of using such precipitation suppression, and / or for the purpose of stabilizing ascorbic acid in a composition containing component (A) over time (for example, improving or enhancing the residual rate), or for the purpose of using such improvement or enhancement.

[0060] <14> In the cases of <13>(1) to (3) above, the amounts of each component, the mass content ratio of each component combination, etc., are not particularly limited as long as the above-mentioned objectives (for example, at least "suppression of ascorbic acid precipitation and / or stabilization of ascorbic acid over time (for example, improvement or enhancement of the remaining rate, etc.)") can be achieved. For example, (A) the content of ascorbic acid is not particularly limited, but 1 to 10% by mass is preferred; (B) the content of glycerin is not particularly limited, but 25 to 65% by mass is preferred; (C) the content of polyhydric alcohol (except for component (B)) is not particularly limited; (D) the content of monohydric lower alcohol is not particularly limited, but 10 to 30% by mass is preferred; and the content of water is not particularly limited, but 10% by mass or less or no water is preferred. Furthermore, as preferred embodiments of the above <13>(1) to (3), each of the configurations or technical features (specific content, specific proportion, specific component, etc.) described in <2> to <11> above may be appropriately adopted. In addition, each of the permissible components and their content, as well as permissible combinations of specific components and permissible mass content ratios, etc., described throughout this specification, including components (A) to (E), and other components, may be appropriately adopted. Furthermore, it is preferable to adopt the preferred configurations or technical features (application of components, content, combinations, mass content ratios, etc.) described throughout this specification. [Examples]

[0061] The present invention will be described in detail below with reference to examples. However, these examples do not limit the present invention in any way.

[0062] <Examples 1-18 and Comparative Examples 1-7: Beauty Serums> Serums with the compositions shown in Tables 1 and 2 were prepared using the manufacturing method described below, and evaluated for the following items: "inhibition of ascorbic acid precipitation (50°C / 1M)", "stability of ascorbic acid over time (50°C / 1M)", "skin smoothness after repeated use", "moisturizing effect", "non-stickiness", and "spreadability", according to the evaluation method and criteria shown below. The results are also shown in Tables 1 and 2. Examples 1-18 and 19-22 had a viscosity of 200 mPa·s or less.

[0063] [Table 1]

[0064] [Table 2]

[0065] Note 1: Ascorbic acid ultrafine powder (manufactured by DSM Corporation) Note 2: PEG-400 (manufactured by Toho Chemical Industry Co., Ltd.) Note 3: NEOSOLUE AQULIO (manufactured by Nippon Seika Co., Ltd.) Note 4: Wilbride S-753D (manufactured by NOF Corporation) Furthermore, the "Hansen solubility parameter" for the compounds used in the [Examples] (corresponding to component (E) in Notes 3 and 4, etc.) is defined as follows: [The δh in the Hansen solubility parameter of component (E) is δh ≤ 8 MPa]. 0.5 The parameters were determined using the PC software "HSPiP: Hansen Solubility Parameters in Practice Ver. 5.4.05", formula (1), and unit "MPa^0.5", in accordance with the description of the water-soluble compound.

[0066] (Manufacturing method) A: Mix and dissolve components (1) to (7), (10), and (11) uniformly at 80°C. B: Cool A to room temperature, add components (8) and (9), and mix. A beauty serum was obtained by filling C:B into a pointed-cap bottle container (cap: part number 27mm pointed cap, manufactured by Takemoto Container Co., Ltd., bottle: part number AO-100, manufactured by Takemoto Container Co., Ltd.).

[0067] [Evaluation Method 1: Inhibition of Ascorbic Acid Precipitation (5℃ / 1M)] To suppress the precipitation of ascorbic acid (component (A)) (5°C / 1M), each sample was stored in a constant temperature bath at 5°C for one month (1M) while shielded from light with aluminum foil. After that, it was left to stand at room temperature for one day, and the presence or absence of precipitates was determined by visual inspection according to the following four-stage judgment criteria. [4-level evaluation criteria] (Judgment) :(Judgment criteria) A (Excellent): No precipitation observed at all. B (Good): Precipitation is present but very slight. C (Slightly unacceptable): Slight precipitation is observed. D (Not acceptable): Significant precipitation is observed.

[0068] [Evaluation Method 2: Stability over time of ascorbic acid (50°C / 1M)] The temporal stability (50°C / 1M) of ascorbic acid (component (A)) was assessed by storing each sample in a 50°C constant temperature bath for one month (1M) while shielded from light with aluminum foil. After standing at room temperature for one day, the ascorbic acid concentration in each sample was measured using high-performance liquid chromatography (HPLC). The stability was determined according to the following four-stage criteria based on the remaining percentage of ascorbic acid calculated using the following formula, with the concentration of ascorbic acid immediately after manufacturing set as 100%. Ascorbic acid retention rate (%) = (Concentration of ascorbic acid in the sample after 50°C and 1M) / (Concentration of ascorbic acid in the sample immediately after preparation) [4-level evaluation criteria] (Judgment) :(Judgment criteria) A (Excellent): Ascorbic acid retention rate is 90% or higher. B (Good): Ascorbic acid retention rate is 80% or more, but less than 90%. C (Somewhat unacceptable): Ascorbic acid retention rate is 70% or more, but less than 80%. D (Not acceptable): Ascorbic acid retention rate is less than 70%

[0069] [Evaluation Method 3: Skin smoothness, moisturizing effect, non-greasy feel, and spreadability after continuous use] To evaluate the smoothness, moisturizing effect, non-greasy feel, and spreadability of the skin after repeated use, a panel of 10 cosmetic evaluation specialists applied 0.5 ml of each sample to their entire face and evaluated it according to the evaluation criteria below, assigning scores. For each sample, the average score was calculated from the sum of the scores of all panel members and judged according to the following criteria. The smoothness and moisturizing effect of the skin after repeated use were judged on a 4-point scale, and the non-greasy feel and spreadability were judged on a 5-point scale. To assess skin smoothness after continuous use, each sample was used morning and evening for two weeks, and the smoothness of the skin upon touch at the end of the continuous use period was evaluated. Regarding moisturizing effect, we evaluated the feeling of moisture immediately after applying each sample. Regarding the lack of stickiness, we evaluated the degree of stickiness immediately after applying each sample. Regarding spreadability, we evaluated how well each sample spread when applied.

[0070] [5-point rating scale] [Rating]:[Evaluation Result] 5 points: very good 4 points: Fairly good 3 points: Neither one nor the other 2 points: Slightly poor 1 point: Very poor [4-level evaluation criteria] [Judgment]: [Average score of the ratings] A (excellent): 4.0 points or more B (Good): 3.5 points or higher, but less than 4.0 points C (Somewhat unacceptable): 2.5 points or higher, but less than 3.5 points. D (Not acceptable): Less than 2.5 points [5-point rating scale] [Judgment]: [Average score of the ratings] AA (Better): 4.5 points or higher A (Excellent): 4.0 points or higher, less than 4.5 points B (Good): 3.5 points or higher, but less than 4.0 points C (Somewhat unacceptable): 2.5 points or higher, but less than 3.5 points. D (Not acceptable): Less than 2.5 points

[0071] Examples 1-18 demonstrated excellent inhibition of ascorbic acid precipitation (50°C / 1M), long-term stability of ascorbic acid, skin smoothness with continuous use, moisturizing effect, non-stickiness, and spreadability. The cosmetic or topical skin preparation of the present invention is suitable for continuous use due to its excellent stability and feel of ascorbic acid, and furthermore, the effect of skin smoothness with continuous use can be felt. In contrast, in Comparative Example 1, where the content of ingredient (A) was less than 1% by mass, the smoothness of the skin after continuous use was not satisfactory. In Comparative Example 2, where the content of component (A) exceeded 10% by mass, precipitation of ascorbic acid and a decrease in its remaining rate were observed, and the smoothness and spreadability of the skin after continuous use were not satisfactory. In Comparative Example 3, where the content of component (B) was less than 25% by mass, precipitation of ascorbic acid and a decrease in the remaining rate were observed, and the smoothness and moisturizing effect on the skin after continuous use were not satisfactory. Comparative Example 4, in which the content of component (B) exceeded 65% by mass, and Comparative Example 5, in which the content of component (D) was less than 10% by mass, were not satisfactory in terms of non-stickiness and spreadability. In Comparative Example 6, where the content of component (D) exceeded 30% by mass, precipitation of ascorbic acid and a decrease in its remaining rate were observed, and the smoothness and moisturizing effect on the skin after continuous use were not satisfactory. In Comparative Example 7, where the water content exceeded 10% by mass, a decrease in the remaining ascorbic acid was observed, and the smoothness and moisturizing effect on the skin after continuous use were not satisfactory.

[0072] Example 19: Serum (component) (mass%) 1. Ascorbic acid (Component (A)) Note 1 5 2. Glycerin (Ingredient (B)) Remaining amount 3. Dipropylene glycol (Component (C)) 10 4.1,3-Butylene glycol (Component (C)) 5 5.PEG-8 (Component (C)) Note 2 5 6. Ethanol (Ingredient (D)) 20 7. PEG / PPG / Polybutylene Glycol-8 / 5 / 3 Glycerin (Component (E)) Note 4 5 8. Tocopherol 0.1 9. Astaxanthin 0.05 10. EDTA-2Na 0.05 11.Fragrance 0.1

[0073] (Manufacturing method) A: Dissolve components (1) to (5) and (7) to (10) uniformly at 80°C. B: Cool A to room temperature. Add components (6) and (11) to C:B and mix.

[0074] The serum of Example 19 demonstrated excellent properties in inhibiting the precipitation of ascorbic acid, maintaining the stability of ascorbic acid over time, smoothing the skin with continued use, providing a moisturizing effect, preventing stickiness, and ensuring good spreadability.

[0075] Example 20: Serum (component) (mass%) 1. Ascorbic acid (Component (A)) Note 1 10 2. Glycerin (Ingredient (B)) Remaining amount 3. Dipropylene glycol (Component (C)) 5 4. Propanediol (Component (C)) 5 5. Isoprene glycol (Component (C)) 5 6. Ethanol (Ingredient (D)) 25 7. Cyclohexane-1,4-dicarboxylic acid bisethoxydiglycol (Component (E)) Note 3 5 8.Purified water 5 9. Hydrogenated lecithin (Note 5) 0.1 10. Hydroxylated lecithin (Note 6) 0.1 11. EDTA-2Na 0.05 12. Phosphorylcholine glycol polyacrylate (Note 7) 1 13. Orange oil 0.1 Note 5: Nikko Resinol S-10EZ (manufactured by Nikko Chemicals Co., Ltd.) Note 6: NIKKOL Resinol WS-50 (manufactured by Nippon Surfactant Co., Ltd.) Note 7: LIPIDURE HM-600 (manufactured by NOF Corporation)

[0076] (Manufacturing method) A: Dissolve components (1) to (5) and (7) to (12) uniformly at 80°C. B: Cool A to room temperature. Add components (6) and (13) to C:B and mix.

[0077] The serum of Example 20 demonstrated excellent properties in inhibiting ascorbic acid precipitation, maintaining the stability of ascorbic acid over time, smoothing the skin with continued use, providing a moisturizing effect, preventing stickiness, and ensuring good spreadability.

[0078] Example 21: Serum (component) (mass%) 1. Ascorbic acid (Component (A)) Note 1 6 2. Glycerin (Ingredient (B)) Remaining amount 3. Dipropylene glycol (Component (C)) 5 4.1,3-Butylene glycol 5 5. Isoprene glycol (Component (C)) 10 6. Ethanol (Ingredient (D)) 15 7. PPG-24 Glycereth-24 Note 8 5 8.Purified water 2 9. PPG-6 Decyltetradeceth-20 Note 9 0.5 9. Tocopherol 0.1 10. Retinyl palmitate (Note 10) 0.05 11. EDTA-2Na 0.05 12. (Glyceryl methacrylate / stearyl methacrylate) copolymer 1 Note 8: PPG-24 Glycereth-24 (manufactured by NOF Corporation) Note 9: NIKKOL SG-DTD620 (manufactured by Nikko Chemicals Co., Ltd.) Note 10: Riken Palmitate 1000(E) (manufactured by Riken Vitamin Co., Ltd.)

[0079] (Manufacturing method) A: Dissolve components (1) to (5) and (7) to (12) uniformly at 80°C. B: Cool A to room temperature. Add ingredient (6) to C:B and mix.

[0080] The serum of Example 21 was excellent in inhibiting the precipitation of ascorbic acid, maintaining the stability of ascorbic acid over time, and providing smooth skin, moisturizing effect, non-stickiness, and good spreadability with continued use.

[0081] Example 22: Serum (component) (mass%) 1. Ascorbic acid (Component (A)) Note 1 6 2. Glycerin (Ingredient (B)) Remaining amount 3. Dipropylene glycol (Component (C)) 5 4.1,3-Butylene glycol 5 5. Isoprene glycol (Component (C)) 10 6. Ethanol (Ingredient (D)) 15 7. PPG-10 Methyl Glucose (δh = 0.1 MPa) 0.5 ) (Ingredient (E) 5 8. PPG-24 Glycereth-24 Note 8 5 9.Purified water 2 10. PPG-6 Decyltetradeceth-20 Note 9 0.5 11. Tocopherol 0.1 12. Retinyl palmitate (Note 10) 0.05 13. EDTA-2Na 0.05 14. (Glyceryl methacrylate / stearyl methacrylate) copolymer 1 Note 8: PPG-24 Glycereth-24 (manufactured by NOF Corporation) Note 9: NIKKOL SG-DTD620 (manufactured by Nikko Chemicals Co., Ltd.) Note 10: Riken Palmitate 1000(E) (manufactured by Riken Vitamin Co., Ltd.)

[0082] (Manufacturing method) A: Dissolve components (1) to (5) and (7) to (14) uniformly at 80°C. B: Cool A to room temperature. Add ingredient (6) to C:B and mix.

[0083] The serum of Example 22 demonstrated excellent properties in inhibiting ascorbic acid precipitation, maintaining the stability of ascorbic acid over time, smoothing the skin with continued use, providing a moisturizing effect, preventing stickiness, and ensuring good spreadability.

Claims

1. The following components (A) to (D): (A) Ascorbic acid 1-10% by mass (B) Glycerin 25-65% by mass (C) Polyhydric alcohols (excluding component (B)) (D) Monohydric lower alcohol 10-30% by mass A cosmetic or topical skin preparation containing an ingredient, with a water content of 10% by mass or less, or containing no water.

2. The cosmetic or topical skin preparation according to claim 1, wherein the IOB value of component (C) is 1.5 to 3.

5.

3. The cosmetic or topical skin preparation according to claim 1 or 2, wherein the mass ratio of component (B) to the total amount of component (C) and component (D) (B) / {(C)+(D)} is 0.3 to 3.

4. Furthermore, the δh in the Hansen solubility parameter of component (E) is δh ≤ 8 MPa. ０．５ A cosmetic or topical skin preparation according to claim 1 or 2, comprising a water-soluble compound.

5. The cosmetic or topical skin preparation according to claim 4, wherein the component (E) is at least one selected from the group consisting of polyoxybutylene polyoxyethylene polyoxypropylene glyceryl ether, polyoxyalkylene alkyl glucoside, and dicarboxylic acid ester.

6. The cosmetic or topical skin preparation according to claim 1 or 2, wherein the mass ratio of component (B) to component (D) (B) / (D) is greater than 1.

1.

7. A cosmetic or topical skin preparation according to claim 1 or 2, for skincare purposes.

8. A method for producing a cosmetic or topical skin preparation according to claim 1 or 2, characterized by heating and mixing at least the components (A) to (C), then adding at least the component (D), and mixing and stirring.

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