Sunscreen composition containing human milk oligosaccharides

Abstract

The present invention relates to an emulsion containing at least one sunscreen activator and having improved sun protection index (SPF) properties, and to a method for improving sun protection index (SPF) properties.

Description

Detailed description of the invention

[0001] The present invention relates to a composition containing at least two different sunscreen activators and having improved sun protection index (SPF) properties, and to a method for improving sun protection index (SPF) properties.

[0002] The use of compositions containing sunscreen activators (also called sunscreens) is very common today. Sunscreen activators in such compositions protect keratinous substances, particularly the skin, from damage caused by UV radiation, including damage from both UVA and UVB rays, which are known to cause wrinkles and contribute to the development of skin diseases such as lupus erythematosus, as well as melanoma and non-melanoma skin cancer. Therefore, the need for sunscreens with high SPF (Sun Protection Factor) is increasing to achieve ultimate skin protection.

[0003] Inorganic sunscreen surfactants are common ingredients used in sunscreens to provide both good stability and excellent skin compatibility, resulting in safe and highly effective sun protection.

[0004] The standard measure for determining the amount of protection a composition containing sunscreen activators provides against UV radiation is the sun protection factor (SPF). However, given the limited number of sunscreen activators approved worldwide, increasing the SPF of compositions containing sunscreen activators can be challenging.

[0005] Therefore, there is still a need for preferably natural ingredients that can increase the SPF of the inorganic sunscreen active ingredients in the composition.

[0006] Surprisingly, it was found that human milk oligosaccharides can significantly increase the SPF of compositions containing at least two different inorganic UV filters selected from the group consisting of zinc oxide and titanium dioxide.

[0007] Accordingly, in a first embodiment, the present invention relates to a composition for keratinous substances (e.g., hair or skin) comprising at least two different inorganic UV filters selected from the group of zinc oxide and titanium dioxide, and at least one human milk oligosaccharide. Preferably, the composition is in the form of a water-in-oil emulsion (W / O emulsion).

[0008] The present invention also relates to a method for enhancing the sun protection index (SPF) properties of a composition comprising at least two different inorganic UV filters selected from the group consisting of zinc oxide and titanium dioxide, the method comprising adding at least one human milk oligosaccharide to the composition in an amount effective for enhancing the SPF properties of the composition.

[0009] The present invention also relates to the use of human milk oligosaccharides to enhance the sun protection index (SPF) of a composition comprising at least two different inorganic UV filters selected from the group consisting of zinc oxide and titanium dioxide.

[0010] The present invention also relates to a method for preparing a composition having improved sun protection index (SPF) properties, comprising adding at least two different inorganic UV filters selected from the group consisting of zinc oxide and titanium dioxide, and at least one human milk oligosaccharide to the composition during the preparation of the composition. It is understood that the improved properties are to be compared with a composition that does not contain human milk oligosaccharides having all the definitions and preferences given herein.

[0011] The present invention further relates to a method for producing a composition, comprising combining at least two different inorganic UV filters selected from the group consisting of zinc oxide and titanium dioxide, and at least one human milk oligosaccharide in the composition.

[0012] The use of the composition of the present invention as a sunscreen composition for protecting the skin from the effects of skin aging, particularly wrinkles (especially from UV-induced skin aging), and for sun protection, is also in accordance with the present invention.

[0013] Finally, the subject matter of the present invention is a method for the cosmetic treatment of keratinous substances, particularly skin, where compositions as defined herein are applied particularly to the keratinous substances, particularly skin. This method is particularly suitable for protecting the skin from the harmful effects of ultraviolet radiation, such as sunburn and / or photoaging.

[0014] The term "keratinous material" means skin (body, face, eye contours, scalp), hair, eyelashes, eyebrows, body hair, nails, and / or lips. Preferably, in all embodiments, the keratinous material is skin.

[0015] The term "human milk oligosaccharides (HMOs)" refers to a family of unconjugated glycans that are very abundant in human breast milk and possess unique structural diversity. Originally, HMOs were found to promote the growth of Bifidobacterium species in the gut and are proposed to be prebiotic "bifidobacterial factors" or human milk glycans that are uniquely found in the stool of breastfed infants compared to infants fed formula.

[0016] The SPF according to the present invention is understood to be measured by the in vitro SPF method outlined in ISO 24443 (Determination of sunscreen UVA photoprotection in vitro, 01.06.2012) and illustrated in the examples.

[0017] HMOs generally consist of five monosaccharides: glucose (Glc), galactose (Gal), N-acetylglucosamine (GlcNAc), fucose (Fuc), and sialic acid (Sia), primarily along with N-acetylneuraminic acid (Neu5Ac) if not the sole form of sialic acid (Sia). To date, more than 200 different HMOs have been identified. The most important HMOs are 2'-fucosyllactose (2'FL), lacto-N-neotetraose (LNnT), 3-fucosyllactose (3FL), difucosyllactose (DFL), lacto-N-fucopentaose I (LNFP I), 3'-sialyllactose sodium salt (3'SL), 6'-sialyllactose sodium salt (6'SL), and lacto-N-tetraose (LNT).

[0018] HMOs can be isolated from breast milk or produced chemically or biochemically. HMOs are available from various manufacturers.

[0019] For the purposes of this invention, the source of the HMO is not important. It is clear that HMOs from various sources can be used.

[0020] Particularly preferred HMOs in all embodiments of the present invention are fucosylated HMOs, for example, α1-2 or α1-3 fucosylated HMOs; sialylated HMOs, for example, sialyl lactose; and neutral core HMOs, as well as any mixture thereof.

[0021] Particularly preferred fucosylated HMOs according to the present invention are 2'-fucosyllactose (2'FL; CAS number: 41263-94-9), 3-fucosyllactose (3FL; CAS number: 41312-47-4), difucosyllactose (DFL; also known as lactodifucotetraose; CAS number: 20768-11-0), and lacto-N-fucopentaose I (LNFP-I; CAS number: 7578-25-8).

[0022] Particularly preferred sialylated HMOs according to the present invention are sialyllactose and its salts (preferably sodium salts), for example, in particular 3′-sialyllactose (3′SL), 6′-sialyllactose (6′SL) and their respective sodium salts (CAS numbers: 35890-39-2 (3′-sialyllactose); 128596-80-5 (3′-sialyllactose sodium salt); 35890-39-2 (6′-sialyllactose); 157574-76-0 (6′-sialyllactose sodium salt)).

[0023] Particularly preferred neutral core HMOs are constructed from galactose, N-acetylglucosamine and glucose monosaccharide units, preferably linked to each other via β-(1-3) or β-(1-4) bonds. Preferably, in all embodiments herein, galactose is D-galactose and glucose is D-glucose.

[0024] In all embodiments of the present invention, particularly preferred neutral core HMOs are lacto-N-triose II, LNT, LNnT, LNH, LNnH, pLNH and pLNnH, and mixtures thereof are also used. The most preferred neutral core HMO in all embodiments of the present invention is lacto-N-(neo)tetraose, i.e., lacto-N-tetraose (CAS number: 14116-68-8) and / or lacto-N-neotetraose (CAS number: 13007-32-4).

[0025] The total amount of HMOs according to the present invention in the composition according to the present invention is preferably at least 0.01 wt%, more preferably at least 0.1 wt%, and even more preferably at least 0.2 wt%, for example at least 0.3 wt% or at least 0.5 wt%, based on the total weight of the composition. In particular, the total amount of at least one HMO according to the present invention in the composition according to the present invention is preferably selected in the range of 0.01 to 10 wt%, more preferably in the range of 0.1 to 7.5 wt%, and most preferably in the range of 0.2 to 5 wt%, based on the total weight of the composition. Further suitable ranges are 0.25 to 5 wt%, 0.5 to 4 wt%, 0.1 to 3 wt%, 0.25 to 3 wt%, and 0.3 to 3 wt%. Particularly preferred ranges according to the present invention are 0.1 to 5 wt%, more preferably 0.25 to 3 wt%, for example 0.25 to 1.5 wt%, 0.5 to 5 wt%, or 0.5 to 4 wt%.

[0026] Preferably, in all embodiments of the present invention, at least one HMO is selected from the group consisting of 2'-fucosyl lactose (2'FL), 3-fucosyl lactose (3FL), difucosyl lactose (DFL), lacto-N-fucopentaose I (LNFP-I), 3'-sialyl lactose sodium salt (3'SL), 6'-sialyl lactose sodium salt (6'SL), lacto-N-neotetraose (LNnT), lacto-N-tetraose (LNT), and mixtures thereof. More preferably, selected from 3'-sialyl lactose sodium salt (3'SL), 3-fucosyl lactose (3FL), 6'-sialyl lactose sodium salt (6'SL), lacto-N-neotetraose (LNnT), lacto-N-tetraose (LNT), difucosyl lactose (DFL), and mixtures thereof, most preferably selected from 2'-fucosyl lactose (2'FL) and 6'-sialyl lactose sodium salt (6'SL), with 2'FL being the most preferred.

[0027] It is well understood that the composition according to the invention may comprise one or more HMOs. However, preferably, the composition according to the invention comprises one or two, more preferably only one HMO, for example, most preferably selected from the group of 2’FL, 3’FL, 3’SL, 6’SL, LNT and / or LNnT. The most preferred HMO in all embodiments of the present invention is 2’FL because it brings about a particularly significant increase in SPF.

[0028] As used herein, the term "inorganic UV filter" refers to any metal oxide particles having the UV filter properties defined above and thus useful for incorporation into a composition as a UV filter. Such inorganic UV filters are well known to those skilled in the art and are often referred to as micronized or ultrafine UV filters, particularly micronized or ultrafine titanium dioxide or zinc oxide.

[0029] In a particularly preferred embodiment, the composition according to the invention comprises at least one titanium dioxide and at least one zinc oxide UV filter. In an even more preferred embodiment, the composition according to the invention comprises only inorganic UV filters as UV filters, particularly at least one titanium dioxide and at least one zinc oxide UV filter, most preferably one titanium dioxide and one zinc oxide UV filter.

[0030] The particle size of such inorganic UV filters is not particularly limited. Generally, a suitable (primary) particle size for efficient UV light absorption is selected in the range of 2 - 200 nm.

[0031] In all embodiments of the present invention, the (total) amount of the inorganic UV filter in the composition according to the invention is preferably selected from the range of 0.5 - 30% by weight, more preferably from the range of 1 - 30% by weight, most preferably from the range of 2 - 30% by weight, based on the total weight of the composition. Further suitable amounts are selected from the ranges of 1 - 25% by weight, 1 - 20% by weight, 1 - 15% by weight, 3.0 - 25% by weight, 4 - 25% by weight, 5 - 20% by weight or 10 - 25% by weight.

[0032] More advantageously, the (total) amount of inorganic titanium dioxide UV filter in the composition according to the present invention is selected from the range of 0.5 to 15% by weight, preferably 1 to 15% by weight, more preferably 2 to 10% by weight, and most preferably 2 to 6% by weight or 3 to 6% by weight, based on the total weight of the composition.

[0033] More advantageously, the (total) amount of inorganic zinc oxide UV filter in the composition according to the present invention is selected from the range of 0.5 to 25% by weight, preferably 1 to 20% by weight, more preferably 2 to 20% by weight, and most preferably 5 to 20% by weight or 7.5 to 20% by weight, based on the total weight of the composition.

[0034] Preferably, when present in the composition according to the present invention, the ratio (w / w) of titanium dioxide UV filter to zinc oxide UV filter is selected from the range of 1:5 to 5:1, preferably 1:2 to 2:1. More preferably, the amount of zinc oxide in the composition according to the present invention is greater than the amount of titanium dioxide, for example, in the range of 5:1 to 1.25:1, most preferably in the range of 2.5:1 to 1.25:1.

[0035] In a particular embodiment, the composition according to the present invention preferably comprises only inorganic UV filters, and in particular only zinc oxide and titanium dioxide UV filters having all the definitions and preferences given herein.

[0036] According to the present invention, it is advantageous for the inorganic UV filter to have a surface coating. The surface coating may include providing a thin hydrophilic or hydrophobic inorganic or organic layer on the metal oxide particles by a method known in itself. According to the present invention, various surface coatings may also include water. As a result of the surface treatment, hydrophilic, amphiphilic, or hydrophobic properties are imparted to the metal oxide.

[0037] Examples of inorganic surface coatings suitable for the purposes of the present invention include aluminum oxide (Al2O3), aluminum hydroxide Al(OH)3, aluminum oxide hydrate (also known as alumina, CAS number 1333-84-2), sodium hexametaphosphate (NaPO3)6, and sodium metaphosphate (NaPO3). n These include silicon dioxide (SiO2) (also known as silica, CAS number: 7631-86-9) and iron oxide (Fe2O3). These inorganic surface coatings may exist alone, in combination, and / or in particular in combination with organic coating materials as outlined below.

[0038] Examples of organic surface coatings suitable for use in the present invention include plant or animal aluminum stearate, fatty acids such as stearic acid and lauric acid, dimethylpolysiloxane (also known as dimethicone), methylpolysiloxane (methicone), simethicone, trimethoxycaprylylsilane, triethoxycaprylylsilane, octyltrimethoxysilane, and cetyl phosphate, such as potassium cetyl phosphate, and any mixture thereof. These organic surface coatings may exist alone, in combination, and / or in combination with inorganic coating materials.

[0039] The crystalline form of titanium dioxide can be any crystalline or amorphous form. For example, titanium dioxide can be any type of amorphous, rutile, anastase, brookite, or a mixture thereof. In all embodiments of the present invention, the crystalline form of titanium dioxide is preferably rutile.

[0040] Furthermore, it is preferable that the zinc oxide is a white powder consisting of zinc oxide existing as a wurtzite-type crystalline structure.

[0041] Titanium dioxide UV filters for use according to the present invention (including any pre-dispersions thereof) are available, for example, from DSM Nutritional Products Ltd. as PARSOL® TX (INCI: titanium dioxide, silica, dimethicone), from Tayca as Micro titanium dioxide MT-01, or from Ishihara Sangyo Co., Ltd. as TTO-55I. Double-coated titanium dioxide having an inner alumina coating and an outer simethicone coating (for example, commercially available from EMD Chemicals Inc / Rona as Eusolex T-2000) is also preferred.

[0042] Zinc oxide UV filters for use according to the present invention (including any predispersions thereof) are available, for example, from BASF as Z-Cote or Z-Cote HP1 (2% dimethicone coating), from Tayca as MZ-505S (5% methicone coating), or from DSM Nutritional Products Ltd as PARSOL® ZX (2-3.5% triethoxycaprylylsilane coating).

[0043] In certain embodiments, the composition according to the present invention comprises, as an inorganic UV filter, at least one double-coated titanium dioxide and at least one coated zinc oxide, most preferably without further ultrafine metal oxide particles (i.e., one double-coated titanium dioxide and one coated zinc oxide).

[0044] Most preferably, in all embodiments of the present invention, the titanium dioxide UV filter is a double-coated titanium dioxide, more preferably a double-coated titanium dioxide having an inner silica and an outer organic coating, or a silica-coated titanium dioxide.

[0045] The inner silica coating layer of the double-coated titanium dioxide preferably consists of at least 0.5% by weight of inorganic silica (based on titanium dioxide). More preferably, the inner coating layer consists of 0.5% to 50% by weight, most preferably 1% to 20% by weight of inorganic silica (based on titanium dioxide).

[0046] The outer coating of the double-coated titanium dioxide is preferably selected from a class of organic coatings, such as silicone oil (e.g., simethicone, methicone, dimethicone, polysilicone-15), alkylsilane (e.g., octyltrimethoxysilane), olefinic acid (e.g., stearic acid), or polyol (e.g., glycerol), and can be applied to the titanium dioxide particles by methods known to those skilled in the art, for example, the method described in FI57124. The outer coating is preferably selected from the group consisting of simethicone, methicone, dimethicone, polysilicone-15, stearic acid, and octyltrimethoxysilane. Most preferably, the outer coating is dimethicone. More preferably, the amount of the outer coating layer is at least 0.25% by weight based on titanium dioxide. The amount of the outer coating is preferably selected from the range of 0.5% to 50% by weight, most preferably from 0.5% to 10% by weight, based on titanium dioxide.

[0047] In all embodiments of the present invention, the double-coated titanium dioxide according to the present invention preferably has a titanium dioxide content selected from the range of 70 to 95% by weight and a silicon dioxide content selected from the range of 5 to 20% by weight, for example, a titanium dioxide content selected from the range of 80 to 90% by weight and a silicon dioxide content selected from the range of 10 to 15% by weight (provided that the total content of titanium dioxide and silicon dioxide is selected from the range of 90 to 100% by weight).

[0048] Preferably, the double-coated titanium dioxide has an average primary particle size in the range of 2 to 100 nm, more preferably in the range of 5 to 50 nm, and most preferably in the range of 10 to 25 nm, and a secondary particle size of 0.025 to 1 μm, for example, preferably 0.05 to 0.075 μm.

[0049] A particularly suitable double-coated titanium dioxide according to the present invention contains a rutile-type titanium dioxide (TiO2) core having a double coating of silica (inner coating) and dimethicone (outer coating), and has a titanium dioxide content in the range of at least 75% by weight, preferably 82-87% by weight, and a silicon dioxide content in the range of at least 10% by weight, preferably 10.5-14.5% by weight, and an average particle size distribution D of 25-100 nm, preferably 40-80 nm. n It has a molecular weight of 50 (analyzed by laser diffraction measurement using Malvern Mastersizer 2000), and this double-coated titanium dioxide is commercially available, for example, from DSM nutritional products Ltd as PARSOL® TX (INCI: titanium dioxide, silica, dimethicone).

[0050] In all embodiments of the present invention, zinc oxide is most preferably either uncoated or coated with triethoxycaprylylsilane. The zinc oxide is most preferably a white powder consisting of zinc oxide existing as a wurtzite-type crystalline structure coated with triethoxycaprylylsilane, with a zinc oxide content of 96-98% and a triethoxycaprylylsilane content of 2-3.5%, and an average particle size of 90-130 nm (analyzed by laser diffraction measurement with Malvern Mastersizer 2000), and is commercially available from DSM nutritional products Ltd as PARSOL® ZX.

[0051] Unless otherwise specified in this specification, all given parts and percentages are by weight, based on the total weight of the composition.

[0052] Preferably, the human milk oligosaccharide according to the present invention and the inorganic UV filter selected from the group consisting of zinc oxide and titanium dioxide are present in the composition and method of the present invention in a weight ratio of 1:50 to 1:1, preferably 1:40 to 1:7.5, more preferably 1:30 to 1:5, for example 1:25 to 1:15. Preferably, the inorganic UV filter selected from the group consisting of zinc oxide and titanium dioxide is present in greater quantities than the HMO on a weight basis.

[0053] Since the compositions according to the present invention are intended for topical application, it is well understood that they include physiologically acceptable media, i.e., media compatible with skin, mucous membranes, and keratinous materials such as keratin fibers. In particular, physiologically acceptable media are cosmetically acceptable carriers.

[0054] As used herein, the term “cosmetically acceptable carrier” refers to all carriers and / or excipients and / or diluents conventionally used in topical cosmetic compositions, particularly skincare formulations.

[0055] The exact amount of the support will depend on the actual amounts of the UV filter and all other optional components (e.g., other active ingredients) that a person skilled in the art would classify as different from the support.

[0056] In a favorable embodiment, the composition according to the present invention comprises, based on the total weight of the composition, 50% to 99%, preferably 60% to 98%, more preferably 70% to 98%, for example, particularly 80% to 95% of the carrier.

[0057] In particularly advantageous embodiments, the carrier in all embodiments of the present invention is further composed of at least 30% by weight, more preferably at least 40% by weight, and most preferably at least 45% by weight of water, for example, particularly 50-90% by weight, 50-80% by weight, 50-75% by weight, or 50-60% by weight of water.

[0058] In particular, the compositions according to the present invention are cosmetic or pharmaceutical compositions, preferably cosmetic (non-therapeutic) compositions.

[0059] In one embodiment, the composition according to the present invention is applied to the keratinized tissue of mammals, for example, particularly human skin or human scalp and hair.

[0060] The term "cosmetic composition" as used in this application is defined in Roempp Lexikon Chemie, 10 th Cosmetic compositions as defined in the 1997 edition, Georg Thieme Verlag Stuttgart, New York, under the title "Kosmetika," and A. Domsch, "Cosmetic Compositions," Verlag fuer chemische Industrie (ed. H. Ziolkowsky), 4 th This refers to cosmetic compositions such as those disclosed in edition, 1992.

[0061] Preferred compositions according to the present invention include skincare formulations, decorative formulations, and functional formulations.

[0062] Examples of skincare formulations include, in particular, photoprotective formulations, anti-aging formulations, formulations for the treatment of photoaging, body oils, body lotions, body gels, treatment creams, skin protective ointments, skin powders, moisturizing gels, moisturizing sprays, moisturizers for the face and / or body, skin tanning formulations (i.e., compositions for artificial / sunless tanning and / or browning of human skin), such as self-tanning creams and skin whitening formulations.

[0063] Examples of decorative formulations include, in particular, lipsticks, eyeshadows, mascaras, dry and moist makeup formulations, blushes and / or powders.

[0064] Examples of functional formulations include, but are not limited to, cosmetics or pharmaceutical compositions containing active ingredients such as hormone preparations, vitamin preparations, plant extract preparations, anti-aging preparations, and / or antimicrobial (antibacterial or antifungal) preparations.

[0065] In certain embodiments, the compositions according to the present invention are photoprotective formulations (sun care products, sunscreens) such as sunscreen lotions, sunscreen creams, sunscreen oils, sunscreen blockers, or day care creams having an SPF. Sunscreen creams, sunscreen lotions, and sunscreen lotions are of particular interest.

[0066] The compositions of the present invention (including carriers) may contain conventional auxiliaries and additives such as preservatives / antioxidants, fatty substances / oils, organic solvents, silicones, thickeners, softeners, emulsifiers, defoamers, aesthetic components such as fragrances, surfactants, fillers, anionic, cationic, nonionic or amphoteric polymers or mixtures thereof, propellants, acidifying or basicizing agents, dyes, colorants / colorants, abrasives, absorbents, chelating agents and / or metal ion sequestering agents, essential oils, skin coolants, astringents, pigments, or any other components commonly incorporated into such compositions.

[0067] According to the present invention, the composition according to the present invention may contain further components such as skin whitening; sun protection; treatment of hyperpigmentation; components for preventing or reducing acne, wrinkles, fine lines, atrophy and / or inflammation; chelating agents and / or metal ion sequestering agents; anti-lipidation and slimming agents (e.g., phytanic acid); firming agents; moisturizing and activating agents; self-tanning agents; analgesics; and agents for improving elasticity and skin barrier properties; and carriers and / or excipients or diluents that have been conventionally used in compositions.

[0068] Unless otherwise specified, the excipients, additives, diluents, etc. described below are suitable for the compositions according to the present invention. The required amounts of cosmetics, dermatological adjuvants, and additives can be easily determined by those skilled in the art based on the desired product.

[0069] Additional components may be added to the oil phase, the aqueous phase, or individually, as deemed appropriate. The method of addition can be readily adapted by those skilled in the art.

[0070] Examples of cosmetic excipients, diluents, auxiliaries, additives, and active ingredients commonly used in the skincare industry and suitable for use in the cosmetic compositions of the present invention are, for example, but are not limited to, those listed in the International Cosmetic Ingredient Dictionary & Handbook by the Personal Care Product Council.

[0071] The cosmetic active ingredients useful in this specification may, in some cases, provide two or more benefits or function through two or more mechanisms of action.

[0072] Naturally, those skilled in the art will select the above-mentioned optional additional components, auxiliaries, diluents, and additives, and / or their amounts, with care, such that the favorable properties inherently associated with the combination according to the present invention are not adversely affected or substantially affected by the intended additions.

[0073] Suitable W / O or W / Si emulsifiers according to the present invention include polyglyceryl-2-dipolyhydroxystearic acid, PEG-30 dipolyhydroxystearic acid, cetyl dimethicone copolyol, polyglyceryl-3 diisostearate polyglycerol ester of oleic acid / isostearate, polyglyceryl-6 hexalicinoleate, polyglyceryl-4 oleate, PEG-8 propylene glycol oleic acid / coconut oil fatty acid, magnesium stearate, sodium stearate, potassium laurate, potassium ricinoleate, sodium coconut fatty acid, sodium talusate, potassium castrate, sodium oleate, and mixtures thereof. Further preferred W / Si emulsifiers are lauryl polyglyceryl-3 polydimethylsiloxyethyl dimethicone and / or PEG-9 polydimethylsiloxyethyl dimethicone and / or cetyl PEG / PPG-10 / 1 dimethicone and / or PEG-12 dimethicone crosspolymer and / or PEG / PPG-18 / 18 dimethicone. At least one W / O emulsifier is used in an amount of preferably about 0.001 to 10% by weight, more preferably 0.2 to 7% by weight, based on the total weight of the composition.

[0074] Further suitable W / O emulsifiers that can be used according to the present invention include: polyglyceryl-2 sesquiisostearate, polyglyceryl-2 oleate, polyglyceryl-3 triolivate, polyglyceryl-3 diisostearate, polyglyceryl-4 isostearate, polycastearate / hemp seedate polyglyceryl-4, polyglyceryl-4 isostearate, polyglyceryl-6 polyricinoleate, and polyglyceryl-10. Decaoleic acid, polyglyceryl-10 pentaoleate, polyglyceryl-3 pentaoleate, polyglyceryl-10 pentahydroxystearate, polyglyceryl-10 heptahydroxystearate, polyglyceryl-10 pentaoleate, PEG-5 hydrogenated castor oil, PEG-7 hydrogenated castor oil, PEG-30 dipolyhydroxystearate, PEG-40 sorbitan peroleate, PEG-2 stearate, PEG-2 oleate, PEG-80 sorbitan oleate, PEG-10 dimethicone, cetyl PEG / PPG-10 / 1 dimethicone, lauryl PEG-8 dimethicone, cetyl PEG / PPG-7 / 3 dimethicone, lauryl PEG-9 polydimethylsiloxyethyl dimethicone These are ceteth-2, sorbeth-20, sorbitan olive, sorbitan isostearate, sorbitan oleate, sorbitan laurate, sorbitan monostearate, sorbitan trioleate, lanolin alcohol, lecithin, glyceryl stearate, propylene glycol hydroxystearate, stearalkonium bentonite, quaternium-90 bentonite, polyoxyethylene lauryl ethylene caprylate, stearyl alcohol ether / fatty glycerides, methyl glucose sesquiisostearate, isostearyl diglyceryl succinate, methyl glucose dioleate, methyl glucose sesquistearate, and oleyl hydroxyethyl imidazoline.

[0075] Particularly suitable W / O emulsifier mixtures used in accordance with the present invention include polyglyceryl-2 sesquiisostearate (and) beeswax (Cera Alba) (and) microcrystalline wax (and) mineral oil (and) magnesium stearate (and) aluminum tristearate (Hostacelin WO), glyceryl oleate (and) polyglyceryl-3 polyricinoleate (and) oleo-European oil unsaponifiables (Plantasens® emulsifier CP5), polyglyceryl-3 polyricinoleate (and) sorbitan oleate (Plantasens® natural emulsifier CP40), and C13-15A Lucan (and) disteardimonium hectorite (and) polyglyceryl-3 polyricinoleate (BENTONE® LUXEXO), caprylic / capric triglyceride (and) stearalkonium hectorite (and) polyglyceryl-3 diisostearate (and) polyglyceryl-3 polyricinoleate (BENTONE® LUXEWN), polyglyceryl-4 diisostearate / polyhydroxystearate / sebacate (and) caprylic / capric triglyceride (and (b) Polyglyceryl-3 Oleate (and) Polyglyceryl-3 Dimer Diisostearoyl Dilinoleate (ISOLAN® 17MB); Polyglyceryl-4 Isostearate (and) Cetyl PEG / PPG-10 / 1 Dimethicone (and) Hexyl Laurate (Silube® PCH); Polyglyceryl-4 Oleate (and) PEG-8 Propylene Glycol Cocoate; Dicocoyl Pentaerythrityl Distearyl Citrate (and) Sorbitan Sesquioleate (and) Cera Alba (and (b) Aluminum stearate (DEHYMULS® E); Cyclopentasiloxane (and) PEG-10 dimethicone (and) disteardimionium hectorite (and) silica dimethylsilylate (iEmulWO); Cetyl PEG / PPG-10 / 1 dimethicone (and) bis-PEG / PPG-14 / 14 dimethicone (and) cyclopentasiloxane (SanCosP2); Cyclopentasiloxane (and) PEG / PPG-19 / 19 dimethicone (DOWSIL® BY11-030);This includes sorbitan oleate (and) hydrogenated castor oil (and) synthetic beeswax (and) stearic acid (and) palmitic acid (ERCAMULSLF81V); polyglyceryl-6 polyhydroxystearate (and) polyglyceryl-6 polyricinoleate (and) polyglyceryl-6 (Emulium® Illustro); ceteareth-6 (and) stearyl alcohol (Feligel 319); and polyglyceryl-2 oleate, polyhydroxystearic acid, and polyglyceryl-2 stearate (PolyAquol® OS2).

[0076] Suitable W / SI emulsifiers for use in accordance with the present invention include, for example, lauryl PEG-9 polydimethylsiloxyethyl dimethicone, PEG-8 dimethicone, lauryl PEG-10 tris(trimethylsiloxy)silylethyl dimethicone, cetyl diglyceryl tris(trimethylsiloxy)silylethyl dimethicone, lauryl PEG-9 polydimethylsiloxyethyl dimethicone, PEG-9 dimethicone, PEG-10 dimethicone, lauryl PEG-9 polydimethylsiloxyethyl dimethicone, and lauryl polyglyceryl-3 polydimethylsiloxyethyl dimethicone.

[0077] Suitable W / Si emulsion mixtures include cyclopentasiloxane (and) PEG-10 dimethicone (and) disteardimonium hectorite (BENTONE® LUXE WS); cyclopentasiloxane (and) dimethicone / PEG-10 / 15 crosspolymer (Andisil® CP2050); cyclopentasiloxane (and) dimethicone (and) PEG / PPG-10 / 15 dimethicone (and) dimethicone / vinyl dimethicone crosspolymer (Cosmethicone® SF-6210); and cyclopentasiloxane (and) PEG / PPG-20 / 15 dimethicone (SF1528).

[0078] Further emulsifiers suitable for use according to the present invention include glyceryl hydroxystearate; polyglyceryl-6 distearate; behenyl behenate; stearyl behenate; stearyl stearate; sorbitan oleate; sorbitan laurate; polysorbate 81; hydrogenated lecithin; polysorbate 28; sorbitan oleate; sorbitan monopalmitate; sorbitan monooleate; sorbitan stearate; sorbitan isostearate; sorbitan palmitate; sorbitan sesquioleate Rubitan; Laureth-9; PEG-20 Methyl Glucose Sesquistearate; PEG-200 Dilaurate; PEG-200 Dioleate; PEG-200 Distearate; PEG-200 Monolaurate; PEG-200 Monooleate; PEG-3 C12-18 Alcohol; Steareth-2 PEG-2 Stearyl Ether; Calcium Stearoyl Lactate; C12-C18 Diglycerides; Sucrose Stearate (and) Sucrose Distearate (NATPURE® SF).

[0079] The amount of oil phase (i.e., the phase containing all oils and fats) present in the composition according to the present invention is preferably at least 10% by weight, for example, in the range of 10 to 70% by weight, preferably in the range of 15 to 60% by weight, and most preferably in the range of 20 to 50% by weight, based on the total weight of the composition.

[0080] In a more preferred embodiment, the compositions of the present invention outlined herein are W / O emulsions comprising an aqueous phase dispersed in an oily phase in the presence of at least one emulsifier from the group consisting of lauryl PEG-10 tris(trimethylsiloxy)silylethyl dimethicone and / or propylene glycol dicaprylate / dicaplate; stearalkonium hectorite; propylene carbonate (MIGLYOL®-Gel 840 B) and / or polyhydroxystearic acid. The preparation of such W / O emulsions is well known to those skilled in the art and is illustrated in the examples.

[0081] Particularly preferred W / O emulsifiers used in accordance with the present invention are polyglyceryl-2 dipolyhydroxystearate, polyglyceryl-3 diisostearate, cetyl PEG / PPG-10 / 1 dimethicone, PEG / PPG-18 / 18 dimethicone, and mixtures thereof.

[0082] The compositions according to the present invention more advantageously contain at least one surfactant, such as one selected from the group consisting of monoglycerides, diglycerides, and / or fatty alcohols. The surfactant is generally used in an amount selected from a range such as 0.1 to 10% by weight, particularly 0.5 to 7% by weight, and most specifically 1 to 5% by weight, based on the total weight of the composition.

[0083] Particularly suitable surfactants are selected from the list of alkyl alcohols such as cetyl alcohol (Lorol C16, Lanette 16), cetearyl alcohol (Lanette O), stearyl alcohol (Lanette 18), behenyl alcohol (Lanette 22), polyhydroxystearic acid, glyceryl stearate, glyceryl myristate (Estol 3650), hydrogenated cocoglyceride (Lipocire Na10), glyceryl caprate, glyceryl dilaurate, glyceryl oleate, glyceryl stearate, glyceryl monostearate, sorbitan oleate, apricot kernel oil polyglyceryl-4 ester, and stearalkonium hectorite.

[0084] In all embodiments of the present invention, it is particularly advantageous that the composition according to the present invention also contains glyceryl caprate, glyceryl dilaurate, glyceryl oleate, glyceryl stearate, glyceryl monostearate, sorbitan oleate and / or stearalkonium hectorite, most preferably glyceryl caprate and / or stearalkonium hectorite.

[0085] As an advantageous embodiment of the composition of the present invention, the composition contains one or more oils selected from di(caprylic acid / capric acid) butylene glycol, phenethyl benzoate, alkyl benzoate (C 12 ~C 15 ), dibutyl adipate, diisopropyl sebacate, dicaprylyl carbonate, dialkyl tartrate (C 12 ~ 13 ), butyl octyl salicylate, diethylhexyl malonate silicylene, hydrogenated castor oil dimer acid, triheptanoin, alkyl lactate (C 12 ~ 13 ), alkyl benzoate (C 16~17 ), propyl heptyl caprylate, tri(caprylic acid / capric acid) glyceride, diethylhexyl 2,6-naphthalenedicarboxylate, octyldodecanol, ethylhexyl coconut oil fatty acid, phenethyl alcohol, propylene carbonate, ethylhexyl coconut oil fatty acid, C15-19 alkane, dimethicone, caprylyl methicone, cyclopentasiloxane, hydrogenated castor oil, mineral oil, isoparaffin, isohexadecane, triisostearin. Preferably, the composition according to the present invention contains, as oils, propylene carbonate, ethylhexyl coconut oil fatty acid, C15-19 alkane, and mixtures thereof.

[0086] In a more advantageous embodiment of the present invention, the composition of the present invention preferably further comprises a preservative and / or preservative booster, selected from the group consisting of ethanol, phenoxyethanol, sodium benzoate, potassium sorbate, phenethyl alcohol, hydroxyactofenone, ethylhexylglycerin, hexylglycerin, glyceryl caprylate, 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-octanediol (caprylyl glycol), 1,2-decanediol and 2-methyl-1,3-propanediol and mixtures thereof, and most preferably selected from the group consisting of phenoxyethanol and ethylhexylglycerin and mixtures thereof. Where present, the preservative and / or preservative booster are used in an amount of preferably 0.01 to 5% by weight, more preferably 0.05 to 4% by weight, and most preferably 0.1 to 3.0% by weight, based on the total weight of the composition.

[0087] According to the present invention, it is advantageous if the composition according to the present invention further comprises one or more alkanediols from the group consisting of 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-octanediol, 1,2-decanediol, and 2-methyl-1,3-propanediol. If one or more alkanediols are present, they are used in an amount of preferably 0.1 to 7% by weight, more preferably 0.5 to 7% by weight, and most preferably 1.0 to 5.0% by weight, based on the total weight of the composition.

[0088] According to the present invention, it is even more advantageous when the composition of the present invention comprises phenoxyethanol, ethylhexylglycerin, glyceryl caprylate and / or phenethyl alcohol, preferably phenoxyethanol and / or ethylhexylglycerin or glyceryl caprylate and / or phenethyl alcohol, most preferably phenoxyethanol and ethylhexylglycerin or glyceryl caprylate and phenethyl alcohol.

[0089] In another advantageous embodiment, the compositions according to the present invention do not contain any parabens, benzethonium chloride, piroctone olamine, lauroyl alginate, methylisothiazolinone, chloromethylisothiazolinone, bronopol, benzalkonium chloride, formaldehyde-releasing compounds, salicylic acid, triclosan, DMDM ​​hydantoin, chlorphenesin, or IPBC (iodopropynyl butylcarbamate).

[0090] The composition according to the present invention may further contain one or more emollients that soothe and soften the skin. Examples of emollients include silicones (dimethicone, cyclomethicone), vegetable oils (grape seed oil, sesame seed oil, jojoba oil, etc.), butters (cocoa butter, shea butter), and petrolatum derivatives (petrolatum, mineral oil).

[0091] In another embodiment, the composition of the present invention includes limonene, citral, linalool, alpha-isomethyl ionone, geraniol, citronellol, 2-isobutyl-4-hydroxy-4-methyltetrahydropyran, 2-tert-pentylcyclohexyl acetate, 3-methyl-5-phenyl-1-pentanol, 7-acetyl-1,1,3,4,4,6-hexamethyltetraline, adipic acid diester, cinnamal, amyl salicylate, alpha-amyl cinnamaldehyde, alpha-methyl ionone, butylphenyl methylpropional, cinnamal, amyl cinnamyl alcohol, anise alcohol, benzoin, benzyl alcohol, benzyl benzoate, benzyl cinnamate, salicylic acid It may contain one or more fragrances selected from benzyl tate, bergamot oil, bitter orange oil, butylphenyl methylpropional, cardamom oil, cedrol, cinnamal, cinnamyl alcohol, citronellyl methylcrotate, citrus oil, coumarin, diethyl succinate, ethyl linalool, eugenol, Ebernia furfrasea extract, hornwort extract, farnesol, guaiawood oil, hexyl cinnamal, hexyl salicylate, hydroxycitronellal, lavender oil, lemon oil, linalyl acetate, mandarin oil, menthyl PCA, methylhexadecane, nutmeg oil, rosemary oil, sweet orange oil, terpineol, tonka bean oil, triethyl citrate, and vanillin.

[0092] The compositions of the present invention may, advantageously, include humectants. Humectants are compounds or mixtures of compounds that, after the cosmetic composition is applied to or spread on the skin surface, impart to the cosmetic composition a quality that reduces water loss from the stratum corneum (also known as transepidermal water loss (TEWL)) and / or has a favorable effect on the hydration of the stratum corneum.

[0093] Non-limiting examples of humectants advantageous for use in the compositions of the present invention include glycerol, lactic acid and / or lactates, particularly sodium lactate, butylene glycol, propylene glycol, 1,3-propanediol, biosaccharide gum-1, wild soybean, ethylhexyloxyglycerol, pyrrolidone carboxylic acid, isomerized sugar, panthenol, and urea. Particularly advantageous is the use of high molecular weight humectants from the group of polysaccharides that are water-soluble and / or water-swellable and / or can be gelled by the power of water. Particularly advantageous are, for example, hyaluronic acid, chitosan, and / or fucose-rich polysaccharides, the fucose-rich polysaccharides which are registered in Chemical Abstracts under registration number 178463-23-5 and are available, for example, from SOLABIA SA under the name Fucogel® 1000. Humidifiers can also be advantageously used, for example, as active anti-wrinkle ingredients to protect against the types of skin changes that occur with skin aging.

[0094] Particularly advantageous humectants used in the compositions according to the present invention are glycerin, sodium hyaluronate, isomerized sugar and / or 1,3-propanediol, in a total amount selected from a range of 0.1 to 5% by weight, more preferably 0.1 to 3% by weight, and even more preferably 0.5 to 3% by weight, based on the total weight of the composition.

[0095] While not essential, advantageously, the compositions of the present invention may further include fillers that, for example, further improve the sensory and cosmetic properties of the formulation and have the effect of evoking or emphasizing a skin feel such as velvet or silk. Advantageous fillers in the sense of the present invention include starch and starch derivatives (e.g., tapioca starch, cross-linked starch phosphate, aluminum starch octenyl succinate, sodium starch octenyl succinate, etc.), Valvance pigments that essentially do not exhibit UV filtering or coloring effects (e.g., Valvance Touch 210 or Valvance Touch 250), and / or Aerosils® (CAS No. 7631-86-9), and / or talc, and / or polyethylene, nylon, and dimethylsilylated silica.

[0096] The aqueous phase of the composition of the present invention may, advantageously, include commonly used cosmetic additives, for example, individually or in combination in each case, alcohols, particularly those with a low number of carbon atoms, preferably ethanol and / or isopropanol or polyols with a low number of carbon atoms, in addition to their ethers, preferably propylene glycol, glycerol, electrolytes, self-tanning agents, and also one or more thickeners, advantageously silicon dioxide, aluminum silicate, polysaccharides and / or derivatives thereof, thickeners that can be selected from the group of hyaluronic acid, xanthan gum, hydroxypropyl methylcellulose, particularly advantageously polyacrylates, preferably thickeners from the group of polyacrylates referred to as Carbopol (examples include 980, 981, 1382, 2984 and 5984 type carbopols). Further advantageous thickeners according to the present invention include those with the INCI name (acrylate / C10-30 alkyl acrylate crosspolymer) (e.g., Pemulen TR 1, Pemulen TR 2, Carbopol 1328 from Lubrizol), as well as Aristoflex AVC (INCI: (ammonium acryloyldimethyltaurate / VP) copolymer) and Simugel NS (INCI: (hydroxyethyl acrylate / sodium acryloyldimethyltaurate) copolymer (and) squalane (and) polysorbate 60).

[0097] According to the present invention, it is particularly preferable when the composition contains a thickening agent. Suitable thickening agents used in accordance with the present invention include xanthan gum, crosslinked acrylate / C10-C30 alkyl acrylate polymers, hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymers, and / or vinylpyrrolidone / hexadecane copolymers, preferably xanthan gum and / or hydroxyethyl acrylate / sodium acryloyldimethyl taurate, most preferably xanthan gum.

[0098] The amount of xanthan gum, if present, is preferably selected in the range of 0.1 to 1% by weight, more preferably in the range of 0.15 to 0.75% by weight, and most preferably in the range of 0.2 to 0.4% by weight, based on the total weight of the composition.

[0099] The oil phase of the composition of the present invention may also advantageously contain commonly used cosmetic auxiliaries, such as dextrin palmitate (Rheopearl KL2, Chiba Flour Milling), dextrin palmitate and C15-19 alkanes (TILAMAR FITS, DSM), polyurethane-79 and caprylic / caprylic triglyceride (Oilkemia 5S, Lubrizol), ethylene / propylene / styrene copolymer and butylene / ethylene / styrene copolymer and pentaerythrityltetra-di-t-butylhydroxyhydrocinnamate and squalane (Veggi Gel, Aiglon), dibutyl lauroyl glutamide and dibutyl ethylhexanoyl glutamide and octyldodecanol (AJK-OD246, Ajinomoto).

[0100] The amount of the thickener (e.g., active thickening polymer), if present, is preferably selected in the range of 0.1 to 15% by weight, more preferably in the range of 0.5 to 10% by weight, and most preferably in the range of 1.0 to 8.0% by weight, based on the total weight of the composition.

[0101] In all embodiments of the present invention, the composition according to the present invention is more preferably to include one or more organic UV filters selected from the group consisting of homosalate, ethylhexyl salicylate, polysilicone-15, ethylhexyl methoxycinnamate, octocrylene, phenylbenzimidazole sulfonic acid or a salt thereof, bisethylhexyloxyphenol methoxyphenyl triazine, ethylhexyl triazone, diethylhexyl butamide triazone, methylene bisbenzotriazolyltetramethylbutylphenol, trisbiphenyl triazine, butyl methoxydibenzoylmethane, and diethylamino hydroxybenzoylhexyl benzoate.

[0102] In another embodiment, the composition may have an SPF of at least 15, preferably at least 20, and most preferably at least 30.

[0103] According to the present invention, it is advantageous when the composition of the present invention includes a film-forming agent. A film-forming agent in the sense of the present invention is a substance having various compositions and is characterized by having the following properties. When the film-forming agent is dissolved in water or another suitable solvent and this solution is then applied to the skin, the film-forming agent forms a film after the solvent evaporates, and this film essentially fixes the UV filter to the skin and enhances the water resistance of the product.

[0104] It is particularly advantageous to select a film-forming agent from the group of polymers based on polyvinylpyrrolidone (PVP).

[0105] For example, vinylpyrrolidone copolymers are particularly preferred, such as PVP hexadecane copolymer and PVP eicosene copolymer, which are available from Ashland under trade names Antaron V216 and Antaron V220.

[0106] Similarly, further polymeric film-forming agents such as sodium polystyrene sulfonate (available from National Starch and Chemical Corp. under the trade name Flexan 130) and / or polyisobutene (available from Rewo under the trade name Rewopal PIB1000) are also advantageous. Further examples of suitable polymers include polyacrylamide (Sepigel 305), polyvinyl alcohol, PVP, (PVP / VA) copolymer, polyglycol, and (acrylate / octylacrylamide) copolymer (Dermacryl 79). It is equally advantageous to use hydrogenated castor oil dimer dilinoleate (CAS 646054-62-8, INCI hydrogenated castor oil dimer dilinoleate) (available from Higher Alcohol Industries Co., Ltd. under the name Risocast DA-H) or PPG-3 benzyl ether myristate (CAS 403517-45-3) (available from Croda Chemicals under the trade name Crodamol STS).

[0107] The amount of composition applied to the skin is not definitive and can be easily adjusted by those skilled in the art. Preferably, the amount is 0.1 to 3 mg / cm³. 2 In the area of ​​skin, for example, preferably 0.1 to 2 mg / cm³ 2 In the area of ​​skin, the most preferred concentration is 0.5 to 2 mg / cm³. 2 It is selected within the area of ​​the skin.

[0108] The following examples are provided to further illustrate the compositions and effects of the present invention. These examples are illustrative and are not intended to limit the scope of the present invention.

[0109] [Examples] [Brief explanation] The 3FL and 6'SL of HMOs were evaluated for their SPF boosting effects. For this purpose, various sunscreens were prepared according to standard methods in the art, as outlined in Tables 1a and 2a.

[0110] [In vitro SPF measurement] In vitro SPF tests were performed on PMMA plates (Helioscreen HD6 plates, 5cm x 5cm, Sa roughness 6μm). Each formulation was administered at a dose of 32.5 mg (i.e., 1.3 mg / cm³). 2 The mixture was evenly applied onto a PMMA plate and allowed to dry for 15 minutes.

[0111] In vitro SPF was measured using a Labsphere 2000 UV Transmittance Analyzer. Each PMMA plate was measured nine times at different points on the plate, yielding 27 data points. The results were calculated as the average of these 27 data points.

[0112] [Table 1]

[0113] [Table 2]

[0114] As shown in Table 1b, 3FL and 6'SL HMOs boost in vitro SPF by 15% to 38% in W / O emulsions.

[0115] [Table 3]

[0116] [Table 4]

[0117] As shown in Table 2b, 3FL and 6'SL HMOs boost in vitro SPF by 24% to 36% in O / W emulsions.

[0118] [Comparison data]

[0119] [Table 5]

[0120] [Table 6]

[0121] [Table 7]

[0122] [Table 8]

[0123] As shown in Tables 3b-I to 3b-III, no significant increase in SPF was observed when using only one type of inorganic or organic pigment.

Claims

1. A composition comprising at least two different inorganic UV filters selected from the group consisting of zinc oxide and titanium dioxide, and at least one human milk oligosaccharide.

2. The composition according to claim 1, wherein the at least one human milk oligosaccharide is present in an amount effective in increasing the SPF of the composition.

3. The composition according to claim 1 or 2, wherein the amount of the at least one human milk oligosaccharide is selected in the range of 0.2 to 5% by weight based on the total weight of the composition.

4. The composition according to claim 1 or 2, wherein the at least one human milk oligosaccharide is selected from the group consisting of 2'-fucosyl lactose, 3-fucosyl lactose, difucosyl lactose, lacto-N-fucopentaose I, 3'-sialyl lactose sodium salt, 6'-sialyl lactose sodium salt, lacto-N-neotetraose, lacto-N-tetraose, and mixtures thereof.

5. The composition according to claim 1 or 2, wherein the total amount of the inorganic UV filter in the composition is selected in the range of 0.5 to 30% by weight based on the total weight of the composition.

6. The composition according to claim 1 or 2, wherein the composition comprises at least one titanium dioxide and at least one zinc oxide UV filter.

7. The inorganic UV filter is surface-coated, according to claim 1 or 2.

8. The composition according to claim 1 or 2, wherein the inorganic UV filter is selected from the group consisting of double-coated titanium dioxide having an inner silica and optionally an outer organic coating, silica-coated titanium dioxide, uncoated zinc oxide, and zinc oxide coated with triethoxycaprylylsilane.

9. The composition according to claim 1 or 2, comprising a carrier consisting of at least 30% by weight of water.

10. The composition according to claim 1 or 2, wherein the composition is an emulsion.

11. The composition according to claim 1 or 2, wherein the composition comprises at least one further UV filter selected from the group consisting of homosalate, ethylhexyl salicylate, polysilicone-15, ethylhexyl methoxycinnamate, octocrylene, phenylbenzimidazole sulfonic acid or a salt thereof, bisethylhexyloxyphenol methoxyphenyl triazine, ethylhexyl triazone, diethylhexyl butamide triazone, methylene bisbenzotriazolyltetramethylbutylphenol, trisbiphenyl triazine, butyl methoxydibenzoylmethane, diethylamino hydroxybenzoylhexyl benzoate, and any mixture thereof.

12. Use of the composition according to claim 1 or 2 for protecting the skin from the effects of skin aging and as a sunscreen composition.

13. A method for enhancing the sun protection factor (SPF) of a composition comprising at least two different inorganic UV filters selected from the group consisting of zinc oxide and titanium dioxide, the method comprising adding at least one human milk oligosaccharide to the composition in an amount effective for enhancing the SPF of the composition.

14. A method for preparing a composition, comprising adding at least two different inorganic UV filters selected from the group consisting of zinc oxide and titanium dioxide, and at least one human milk oligosaccharide to the composition during the preparation of the composition.

15. Use of at least one human milk oligosaccharide to increase the SPF of a composition comprising at least two different inorganic UV filters selected from the group consisting of zinc oxide and titanium dioxide.