Treatment planning for delivering tumor treatment sites using patient data

Abstract

A method for a treatment plan for delivering a tumor treatment site to a subject, the method comprising: acquiring a plurality of treatment locations for delivering a tumor treatment site to a subject, each treatment location comprising a plurality of transducer locations for delivering a tumor treatment site to a subject; delivering a tumor treatment site to a subject using transducers placed on the subject, recording data obtained from delivering the tumor treatment site to the subject; removing the plurality of transducers from the subject; and selecting at least one of the treatment locations for further delivering a tumor treatment site to the subject.

Description

Technical Field

[0001] [Cross - Reference to Related Applications] This application claims the benefit of priority from U.S. Patent Application No. 18 / 746,363, filed on Jun. 18, 2024, and U.S. Provisional Application No. 63 / 524,534, filed on Jun. 30, 2023, the entire contents of which are incorporated herein by reference.

Background Art

[0002] A Tumor Treating Field (TT - field) is a low - intensity alternating electric field within an intermediate frequency range (e.g., 50 kHz to 1 MHz) and may be used for the treatment of tumors as described in U.S. Patent No. 7,565,205. The TT - field is non - invasively induced in a target area by applying an alternating voltage between transducers placed on a patient's body. Conventionally, transducers used to generate a TT - field include a plurality of electrode elements including ceramic disks. One side of each ceramic disk is placed in contact with the patient's skin, and the other side of each disk has a conductive backing. Electrical signals are applied to this conductive backing, and these signals are capacitively coupled into the patient's body through the ceramic disks. Conventional transducer designs include arrays of ceramic disks attached to a subject's body through a conductive skin - contact layer such as a hydrogel. At time intervals, an AC voltage is applied between a pair of transducers, generating an electric field with electric field lines running generally in the anterior - posterior direction. Next, an AC voltage is applied at a different time interval at the same frequency between at least another pair of transducers, generating an electric field with electric field lines running generally in the left - right direction. The system repeats this two - step sequence over the course of treatment.

Summary of the Invention

Means for Solving the Problems

[0003] A computer - implemented method for a treatment plan for delivering a Tumor Treating Field to a subject, the method comprising: [[ID=2^5]] Acquiring multiple therapeutic locations for delivering a tumor treatment site to a subject, wherein each therapeutic location includes multiple transducer locations for delivering the tumor treatment site to the subject. For each treatment location, The tumor treatment area is delivered to the subject using a transducer placed on the subject, To record data obtained from delivering the tumor treatment site to the subject, The method includes selecting at least one of the treatment locations to further deliver the tumor treatment site to the subject, based on the data recorded from delivering the tumor treatment site to the subject.

[0004] A device for a treatment plan for delivering a tumor treatment site to a subject, wherein the device is A voltage generator that generates a voltage for delivering the tumor treatment field to the subject via a transducer placed on the subject, One or more sensors that measure at least one parameter related to delivering the tumor treatment site to the subject, An input device for receiving feedback from the subject regarding the delivery of the tumor treatment site to the subject, A controller comprising one or more processors and a memory accessible by the one or more processors, the memory storing, when executed by the one or more processors, instructions to operate the controller to instruct the voltage generator to generate a signal for the tumor treatment field until the current measured from the delivery of the tumor treatment field to the subject reaches a steady state over a predetermined period of time, The memory stores log files for recording information from one or more sensors and the input device. [Brief explanation of the drawing]

[0005] [Figure 1]This describes an exemplary method for a treatment plan to deliver the TT field to a subject. [Figure 2] This illustrates an exemplary system for delivering a TT field to a subject's body. [Figure 3A] A schematic diagram of an exemplary design for a transducer for applying an alternating electric field is shown. [Figure 3B] A schematic diagram of an exemplary design for a transducer for applying an alternating electric field is shown. [Figure 4] An example of transducer placement on the subject's head is shown. [Figure 5] An example of a computer device is shown. [Modes for carrying out the invention]

[0006] This application describes exemplary techniques for a treatment plan for delivering a TT field to a subject by evaluating various possible treatment locations for delivering the TT field to the subject.

[0007] Determining the therapeutic locations for delivering the TT field to a subject can be an extremely complex process involving vast amounts of data and advanced computational processing. Calculating the complex algorithms required to determine the therapeutic locations can be time-consuming. For example, determining the therapeutic locations for delivering the TT field to a subject may require acquiring multiple medical images of the subject, processing the images to determine the location of tumors within the subject, assigning conductivity to the subject's tissue type, generating a 3D model of the subject, simulating the application of the TT field to numerous transducer locations on the subject, calculating the dosage of the TT field for each simulated transducer location, and selecting one or more transducer locations to apply the TT field to the subject.

[0008] The inventors recognized the need for a lower-cost, less computationally intensive, and / or time-consuming process for developing treatment plans to deliver the TT field to subjects.

[0009] The technology of the present invention is particularly integrated into practical applications. An exemplary treatment plan for delivering the TT field is determined based on data obtained for various possible treatment locations by actually delivering the TT field to various possible treatment locations. Based on the information obtained about the subject, various possible treatment locations to be used for examination can be acquired. Data is obtained by using different treatment locations of the transducer on the subject to determine which treatment location(s) is optimal for the subject. For each treatment location, the TT field is delivered until at least a steady state is reached. Data is received from sensors and the subject for each treatment location. The data is processed and presented to select one or more treatment locations(s) for further application of the TT field to the subject. The ingenious technology described herein makes it possible to evaluate many transducer locations much faster than the prior art.

[0010] Figure 1 shows an exemplary method 100 for selecting one or more therapeutic sites for delivering a TT field to a subject. Embodiments of method 100 may be implemented by a computer, which includes one or more processors and memory accessible by one or more processors, the memory storing instructions that, when executed by one or more processors, cause the computer to perform certain steps of method 100. For example, steps S102, S108, S110, and S114 may be implemented by the computer. Modifications, additions, or omissions may be made to method 100. While the sequence of operations is shown in Figure 1 for illustrative purposes, the timing and sequence of such operations may be modified where appropriate without prejudice to the purpose and merits of the examples, which are described in detail throughout the remainder of this disclosure.

[0011] Method 100 includes, in step S102, acquiring a plurality of therapeutic locations for delivering a TT field to a subject, each of which comprises a plurality of transducer locations for delivering a TT field to the subject. For example, each of the plurality of therapeutic locations may comprise four transducer locations for delivering a tumor therapeutic field to the subject, and each of the plurality of transducer locations may comprise a first pair of transducer locations and a second pair of transducer locations for alternately applying an alternating electric field to the subject. The therapeutic locations may be located on a specific part of the subject (e.g., head, torso, abdomen, etc.) and direct the TT field toward a region of interest (may be multiple) (e.g., a tumor) within the subject.

[0012] In some embodiments, the specific positions of the transducers at each treatment location obtained in step S102 may differ in terms of at least one position for the transducer. For example, if there are four positions (1A, 1B, 1C, 1D) for placing the transducer on the subject at the first treatment location, it is not possible to set the same four positions at other treatment locations. Thus, other treatment locations may have zero, one, two, or three of the same locations as the first treatment location. In a further example, Figure 4 may be considered to show a treatment location having four treatment locations on the subject's head for placing four transducers 400A, 400B, 400C, and 400D. No other treatment location may have the same four positions as transducers 400A, 400B, 400C, and 400D. Other treatment locations may have zero, one, two, or three of the same locations as transducers 400A, 400B, 400C, and 400D.

[0013] In some embodiments, multiple treatment locations may be determined based on at least one medical image of the subject (e.g., an X-ray image, magnetic resonance imaging (MRI), computed tomography (CT) image, ultrasound image, or any image providing an internal view of the subject's body). For example, multiple treatment locations may be generated by a computer implementation method based on at least one medical image of the subject. In another example, multiple treatment locations may be selected from a database of treatment locations based on the subject's attributes. Specifically, the subject's attributes may include one or more of the following: sex, race, age, height, weight, medical history, daily activities, or occupation.

[0014] In step S104, method 100 may also include performing steps S106 to S112, which are further described below, for each of the multiple treatment locations obtained in step S102.

[0015] In step S106, method 100 may include placing a plurality of transducers on a subject, each of which transducers is positioned on the subject according to its individual transducer position for the treatment location obtained in step S102. Specifically, for each treatment location as the method loops from step S104 to step S106, the plurality of transducers may be positioned on the subject at predetermined positions for a particular treatment location. For example, as shown in Figure 4, four transducers may be positioned on the subject's head. In the next loop of the method, in step S106, the plurality of transducers may be positioned on the subject at predetermined positions for the next treatment location. As described above, the treatment locations differ in that there is at least one position for the transducers. In some embodiments, transducers may be positioned on the subject by fixing them to the subject or by placing them on or near the subject. In some embodiments, transducers may be placed near the subject without fixing the transducers to the subject. For example, the transducer may be positioned on the subject by using an adhesive on the side of the transducer facing the subject to secure the transducer to the subject. Alternatively, the transducer may be positioned on or near the subject using clothing worn and / or attached to the subject, with the transducer being incorporated into and / or attached to the clothing.

[0016] In step S108, method 100 may include delivering the TT field to the subject using a transducer placed on the subject. In some embodiments, the tumor treatment field may be delivered over a predetermined time period, and after the predetermined time period has elapsed, delivery of the tumor treatment field at that treatment site may be stopped. Since the method loops back from step S112 to step S104, the same time period may be used for each treatment site. For example, the tumor treatment field may be delivered for a time period sufficient for the subject to receive the entire dose of the tumor treatment field. The time period for the subject to receive the entire dose of the tumor treatment field may be determined based on the subject's size, shape, and / or physical characteristics. Because subjects differ in size, shape, and physical characteristics, the time period for the subject to receive the entire dose of the tumor treatment field may differ among subjects. In some embodiments, the time period may be the same for all subjects. For example, the TT field may be delivered for about 30 minutes to about 6 hours for each treatment site. As another example, the TT field may be delivered to each treatment site for at least approximately 30, 45, 60, 75, 90, 105, or 120 minutes.

[0017] In some embodiments, the tumor treatment field may be delivered based on a function of the tumor treatment field delivered to the subject, rather than on a predetermined time. Thus, since the method loops back from step S112 to step S104 for the subject, the tumor treatment field may be delivered at each treatment site with a different time allocation. For example, for each treatment site, the tumor treatment field may be delivered based on the fact that a measured parameter related to the tumor treatment field has reached a steady state. For example, for each treatment site, the tumor treatment field may be delivered until a predetermined time has elapsed after the delivery of the tumor treatment field has reached a steady state. For example, for each treatment site, the tumor treatment field may be delivered until the delivery of the tumor treatment field remains stable over a predetermined time period. For example, for each treatment site, the tumor treatment field may be delivered until at least one measured electrical parameter related to delivering the tumor treatment field to the subject reaches a steady state over a predetermined time period, where at least one measured electrical parameter is current or voltage. In some embodiments, a steady state for a measured electrical parameter is reached when the measured electrical parameter remains constant without substantial ringing over a predetermined time period.

[0018] For example, in some embodiments, the steady state for the measured electrical parameter is reached when the measured electrical parameter is within about 0.2% to about 2%, or about 0.5% to about 1%, or about 0.2% to about 0.5%, or about 0.3% to about 0.7% of a predetermined constant value over a predetermined time period. In some embodiments, the steady state for the measured electrical parameter is reached when the measured current is within about 0.2% to about 2%, or about 0.5% to about 1% of a constant value over a predetermined time period. In some embodiments, the steady state for the measured electrical parameter is reached when the measured current is within about 0.02 to about 0.2 amperes, or about 0.05 to about 0.1 amperes of a constant value over a predetermined time period. In some embodiments, the steady state for the measured electrical parameter is reached when the measured voltage is within 0.2% to about 2%, or about 0.5% to about 1% of a constant value over a predetermined time period. In some embodiments, the steady state for the measured electrical parameter is reached when the measured voltage is within about 0.02 to about 0.2 volts, or about 0.05 to about 0.1 volts of a predetermined constant value over a predetermined time period.

[0019] As an example, the predetermined time period for the steady state of the measured electrical parameter may be between about 1 minute and about 15 minutes. As an example, the predetermined time period may be between about 3 minutes and about 7 minutes.

[0020] In step S110, method 100 may include recording data from delivering the TT field to the subject. In some embodiments, data may be automatically recorded in a log file while the TT field is being delivered to the subject. In one example, for each treatment position, the data recorded from the delivery of the TT field to the subject may include any one or more of the measured voltage, measured current, measured temperature, data regarding the transducer's contact with the subject, and subjective data such as the subject's comfort information from the delivery of the TT field to the subject.

[0021] In some embodiments, subjective data may be obtained from the subject regarding the delivery of the tumor treatment site to the subject. Subjective data may be obtained for each treatment site before, during, and / or after delivery of the tumor treatment site to the subject. For example, subjective data may include one or more of the following: the subject's or caregiver's ability to attach the transducer to the subject, the subject's comfort while wearing the transducer, the subject's ability to move while wearing the transducer, or the subject's or caregiver's ability to remove the transducer from the subject. For example, subjective data may include the state of the transducer after it has been removed from the subject. For example, the recorded condition after the transducer has been removed from the subject may include whether each transducer is in the same condition as when it was attached to the subject, whether at least one transducer is in a different condition than when it was attached to the subject, the number of transducers in the same condition, the number of transducers in a degraded state, the number of transducers with torn or cracked substrates, the number of transducers with electrode elements at least partially detached from the substrate, the number of transducers with missing hydrogel, and the number of transducers with missing adhesive or reduced adhesion. In particular, subjective data may be recorded as numerical values ​​within a numerical range. For example, the numerical range of subjective data may include a first endpoint and a second endpoint, where the first endpoint of the numerical range may correspond to the most comfortable state for the subject, and the second endpoint of the numerical range may correspond to the most uncomfortable state for the subject.

[0022] In step S112, method 100 may include removing a plurality of transducers from the subject. As described above, method 100 may further include repeating steps S106-S112 for each of the plurality of treatment sites obtained in step S102. In some embodiments, the plurality of transducers removed from the subject may be applied to the next treatment site to deliver the TT field to the subject. In some embodiments, the transducers are not reused, and a new transducer is applied to each treatment site to deliver the TT field to the subject. Once steps S106-S110 have been performed for each of the plurality of treatment sites, the process proceeds to step S114.

[0023] In step S114, method 100 may include selecting at least one of the treatment sites as a desired location(s) for further delivery of the TT field to the subject. For example, at least one selected treatment site may be selected based on data recorded for each treatment site from step S110. More specifically, the selection may be based on processed data obtained by processing the data recorded for each treatment site from step S110. In some embodiments, the processed data may include at least one of the following: a measured current in a steady state for delivery of the tumor treatment field to the subject, a resistance value calculated from the measured current and measured voltage, an average measured temperature, or subjective data exceeding a predetermined threshold. In some embodiments, the processed data may be obtained by processing the data recorded for each treatment site and may be displayed simultaneously for each treatment site. Treatment sites may be ranked individually or in combination based on one or more of the processed data. For example, the treatment site with the highest steady current may be selected. In another example, the treatment site with the highest normalized score based on steady current and average measured temperature may be selected.

[0024] Exemplary device

[0025] Figure 2 shows an exemplary apparatus 200 for applying an alternating current field (e.g., a TT field) to a subject's body. This system may be used to treat a target area of ​​the subject's body with the alternating current field. In one example, the target area may be in the subject's brain, and the alternating current field may be delivered to the subject's body via two pairs of transducers positioned on the subject's head (e.g., four transducers 400A, 400B, 400C, and 400D in Figure 4). In another example, the target area may be in the subject's torso, and the alternating current field may be delivered to the subject's body via two pairs of transducers positioned on at least one of the subject's chest, abdomen, or one or both thighs. Other placements of transducers on the subject's body may also be possible.

[0026] Exemplary apparatus 200 illustrates an exemplary system having four transducers (or "transducers") 200A-D. Each transducer 200A-D may include substantially flat electrode elements 202A-D, disposed on substrates 204A-D and electrically and physically connected (e.g., via conductive wiring 206A-D). The substrates 204A-D may include, for example, cloth, foam, flexible plastic, and / or conductive medical gel. Two transducers (e.g., 200A and 200D) may be a first pair of transducers configured to apply an alternating electric field to a target area of ​​the subject's body. The other two transducers (e.g., 200B and 200C) may be a second pair of transducers similarly configured to apply an alternating electric field to a target area.

[0027] Transducers 200A-D may be coupled to an AC voltage generator 208, and the system may further include a controller 210 communicatively coupled to the AC voltage generator 208. The controller 210 may include a computer including one or more processors 212 and a memory 214 accessible by one or more processors. The memory 214 may store instructions, when executed by one or more processors, that cause the computer to control the AC voltage generator 208 to induce an alternating electric field between transducer pairs 200A-D according to one or more voltage waveforms, and / or to execute one or more methods disclosed herein. The controller 210 may monitor operations performed by the AC voltage generator 208 (e.g., via a processor 212). One or more sensors 216 may be coupled to the controller 210 to provide measurements or other information to the controller 210.

[0028] Electrode elements 202A-D may be capacitively coupled. In one example, electrode elements 202A-D are ceramic electrode elements coupled to each other via conductive wiring 206A-D. The ceramic electrode elements may be circular or non-circular when viewed from a direction perpendicular to their surface. In another embodiment, the array of electrode elements is not capacitively coupled, and there is no dielectric material (such as a ceramic or high-dielectric polymer layer) associated with the electrode elements.

[0029] The structure of transducers 200A-D can take various forms. The transducer may be fixed to the subject's body, or attached to or incorporated into clothing covering the subject's body. The transducer may include suitable materials for attaching it to the subject's body. For example, suitable materials may include cloth, foam, flexible plastic, and / or conductive medical gel. The transducer may be conductive or non-conductive.

[0030] A transducer may include any desired number of electrode elements (e.g., one or more electrode elements). For example, a transducer may include one, two, three, four, five, six, seven, eight, nine, ten, or more electrode elements (e.g., twenty electrode elements). Electrode elements may be of various shapes, sizes, and materials. Any structure for implementing a transducer (or electric field generator) used in conjunction with embodiments of the present invention may be used, insofar as they are capable of (a) delivering a TT electric field to the body of a subject and (b) being positioned at locations specified herein. In certain embodiments, at least one electrode element of the first, second, third, or fourth transducer may include at least one ceramic disc adapted to generate an alternating electric field. In non-limiting embodiments, at least one electrode element of the first, second, third, or fourth transducer may include a polymer film adapted to generate an alternating electric field.

[0031] Figure 3A shows a schematic diagram of an exemplary design of a transducer for applying an alternating electric field. The transducer 301 includes 20 electrode elements 302 arranged on a substrate 303, which are electrically and mechanically connected to one another by conductive wiring 304. In some embodiments, the electrode elements 302 may include ceramic disks.

[0032] Figure 3B shows a schematic diagram of an exemplary design of a transducer for applying an alternating electric field. Each transducer 305 may include substantially flat electrode elements 306. In some embodiments, the electrode elements 306 are a non-ceramic dielectric material arranged across a plurality of flat conductors. Examples of non-ceramic dielectric materials arranged across flat conductors may include polymer films arranged across pads on a printed circuit board or across flat metal pieces. In some embodiments, such polymer films have a high dielectric constant, for example, greater than 10. In non-limiting embodiments, the electrode elements 306 may have a variety of shapes. For example, the electrode elements may be triangular, rectangular, circular, oval, ovaloid, ovoid, or elliptical in shape, or substantially triangular, substantially rectangular, substantially circular, substantially oval, substantially ovaloid, substantially ovoid, or substantially elliptical in shape. In some embodiments, each of the electrode elements 306 may have the same shape, a similar shape, and / or a different shape.

[0033] Figure 5 shows an exemplary computer device for use in embodiments of this specification. For example, the device 500 may be a computer for implementing certain inventive techniques disclosed herein, such as selecting at least one transducer arrangement for delivering a TT field to a subject, as in Figure 1. For example, steps S102, S108, S110, and S114 in Figure 1 may be performed by a computer, such as the computer device 500. For example, the device 500 may be used as the controller 210 in Figure 2, or as a separate computer device located remotely from the controller 210. For example, steps S102, S108, S110, and S114 in Figure 1 may be performed by a controller, such as the controller 210. The device 500 may include one or more processors 502, memory 503, one or more input devices, and one or more output devices 505.

[0034] In one example, based on input 501, one or more processors 502 generate control signals for controlling a voltage generator. In one example, input 501 is a user input. In another example, input 501 may be from another computer communicating with the controller device 500. Memory 503 is accessible by one or more processors 502 (e.g., via link 504) so ​​that one or more processors 502 can read information from and write information to memory 503. Memory 503 may store instructions that, when executed by one or more processors 502, implement one or more methods of the present disclosure. Memory 503 is a non-temporary computer-readable medium (or non-temporary processor-readable medium) containing a set of instructions for a treatment plan to deliver a tumor treatment field to a subject, and when executed by a processor (such as one or more processors 502), the processor executes one or more methods described herein by the instructions. Input 501 may be received in combination with one or more input devices (not shown) of the device 500.

[0035] The apparatus 500 may be an apparatus for selecting at least one transducer arrangement for a treatment plan to deliver a tumor treatment site to a subject, the apparatus including one or more processors (such as one or more processors 502), and a memory accessible by one or more processors (such as memory 503) that, when executed by one or more processors, stores instructions causing the apparatus to perform one or more of the methods described herein.

[0036] One or more output devices 505 may provide information about the operation of the present invention, such as transducer placement selection, generated voltage, and other operational information. Output devices 505 may provide visualization data according to a particular embodiment of the present invention.

[0037] Exemplary Embodiments

[0038] The present invention includes other exemplary embodiments ("Embodiments") as follows:

[0039] Embodiment 1: A computer implementation method for a treatment plan for delivering a tumor treatment site to a subject, the method comprising: acquiring a plurality of treatment locations for delivering the tumor treatment site to a subject, each treatment location comprising a plurality of transducer locations for delivering the tumor treatment site to the subject; delivering the tumor treatment site to the subject using transducers placed on the subject for each treatment location; recording data obtained from delivering the tumor treatment site to the subject; and selecting at least one of the treatment locations for further delivering the tumor treatment site to the subject based on the data obtained from delivering the tumor treatment site to the subject.

[0040] Embodiment 1A: The method according to Embodiment 1, further comprising: arranging a plurality of transducers on the subject for each treatment site, wherein each transducer is positioned on the subject according to its respective transducer position corresponding to the treatment site; and delivering the tumor treatment site to the subject using the transducers positioned on the subject, and then removing the plurality of transducers from the subject.

[0041] Embodiment 2: The method according to Embodiment 1, wherein the plurality of treatment locations are generated by a computer implementation method based on at least one medical image of the subject.

[0042] Embodiment 3: The method according to Embodiment 1, wherein the plurality of treatment locations are generated based on at least one medical image of the subject.

[0043] Embodiment 4: The method according to Embodiment 1, wherein the at least one medical image of the subject includes a magnetic resonance imaging (MRI) medical image or a computed tomography (CT) medical image of the subject.

[0044] Embodiment 5: The method according to Embodiment 1, wherein the plurality of treatment locations are selected from a database of treatment locations based on the attributes of the subject.

[0045] Embodiment 6: The method according to Embodiment 5, wherein the attributes of the subject include one or more of the following: gender, race, age, height, weight, medical history, daily activities, or occupation.

[0046] Embodiment 7: The method according to Embodiment 1, wherein each of the plurality of treatment locations includes four transducer locations for delivering a tumor treatment field to a subject, and each of the four transducer locations includes a first pair of transducer locations and a second pair of transducer locations for alternately applying an alternating electric field to the subject.

[0047] Embodiment 8: The method according to Embodiment 1, wherein each transducer is fixed on the head of the subject at each treatment position.

[0048] Embodiment 9: The method according to Embodiment 1, wherein each transducer is fixed to the torso of the subject at each treatment position.

[0049] Embodiment 10: The method according to Embodiment 1, wherein the tumor treatment area is delivered to each treatment site in approximately 30 minutes to approximately 6 hours.

[0050] Embodiment 11: The method according to Embodiment 1, wherein for each treatment site, the tumor treatment site is delivered for at least about 30 minutes, 45 minutes, 60 minutes, 75 minutes, 90 minutes, 105 minutes, or 120 minutes.

[0051] Embodiment 12: The method according to Embodiment 1, wherein for each treatment site, the tumor treatment field is delivered until at least one measured electrical parameter related to delivering the tumor treatment field to the subject reaches a steady state over a predetermined time period, the at least one measured electrical parameter being current or voltage.

[0052] Embodiment 13: The method according to Embodiment 12, wherein the predetermined time period is approximately 1 minute to approximately 15 minutes.

[0053] Embodiment 14: The method according to Embodiment 12, wherein the predetermined time period is approximately 3 minutes to approximately 7 minutes.

[0054] Embodiment 15: The method according to Embodiment 12, wherein the steady state for the measured electrical parameters is reached when the measured electrical parameters remain constant without substantial ringing over a predetermined time period.

[0055] Embodiment 16: The method according to Embodiment 12, wherein the steady state for the measured electrical parameters is reached when the measured electrical parameters fall within approximately 1% of a certain value over the predetermined time period.

[0056] Embodiment 17: The method according to Embodiment 12, wherein the steady state for the measured electrical parameters is reached when at least one of the following occurs: the measured current falls within approximately 0.02 amperes to approximately 0.2 amperes from a constant value over the predetermined time period, or the measured voltage falls within approximately 0.02 volts to approximately 0.2 volts from a constant value over the predetermined time period.

[0057] Embodiment 17A: The method according to Embodiment 12, wherein the steady state for the measured electrical parameters is reached when the measured current falls within approximately 0.2% to approximately 2% of a constant value over the predetermined time period.

[0058] Embodiment 17B: The method according to Embodiment 12, wherein the steady state for the measured electrical parameters is reached when the measured current falls within a range of approximately 0.02 amperes to approximately 2 amperes from a constant value over the predetermined time period.

[0059] Embodiment 18: The method according to Embodiment 12, wherein the steady state for the measured electrical parameters is reached when the measured voltage falls within approximately 0.2% to approximately 2% of a constant value over the predetermined time period.

[0060] Embodiment 19: The method according to Embodiment 12, wherein the steady state for the measured electrical parameters is reached when the measured voltage falls within approximately 0.02 volts to approximately 0.2 volts from a constant value over the predetermined time period.

[0061] Embodiment 20: The method according to Embodiment 1, wherein for each treatment location, the data recorded from delivering the tumor treatment area to the subject includes measured voltage and measured current from delivering the tumor treatment area to the subject.

[0062] Embodiment 21: The method according to Embodiment 1, wherein for each treatment location, the data recorded from delivering the tumor treatment site to the subject includes the temperature measured from delivering the tumor treatment site to the subject.

[0063] Embodiment 22: The method according to Embodiment 1, wherein, for each treatment location, the data recorded from delivering the tumor treatment site to the subject includes subjective data obtained from the subject regarding the delivery of the tumor treatment site to the subject.

[0064] Embodiment 23: The method according to Embodiment 22, wherein the subjective data includes at least one of the following: the ability of the subject or caregiver to attach the transducer to the subject; the subject's comfort while wearing the transducer; the subject's ability to move while the transducer is fixed to the subject; or the ability of the subject or caregiver to remove the transducer from the subject.

[0065] Embodiment 24: The method according to Embodiment 22, wherein the subjective data is recorded as a numerical value within a numerical range, the first endpoint of the numerical range corresponds to the most comfortable state for the subject, and the second endpoint of the numerical range corresponds to the most uncomfortable state for the subject.

[0066] Embodiment 25: The method according to Embodiment 1, wherein, for each treatment location, the data recorded from delivering the tumor treatment area to the subject includes the subject's comfort information.

[0067] Embodiment 26: The method according to Embodiment 1, wherein, for each treatment site, the data recorded from delivering the tumor treatment site to the subject includes subjective data regarding the state of the transducer after it has been removed from the subject.

[0068] Embodiment 27: The method according to Embodiment 1, wherein, for each treatment site, the data is automatically recorded in a log file while the tumor treatment site is delivered to the subject.

[0069] Embodiment 28: The method according to Embodiment 1, further comprising processing the data recorded for each treatment site to obtain processed data, and selecting at least one of the treatment sites for further delivery of the tumor treatment site to the subject, which is done based on the processed data.

[0070] Embodiment 29: The method according to Embodiment 28, wherein the processed data includes at least one of the following: a current measured in a steady state for delivering the tumor treatment field to the subject, a resistance value calculated from the measured current and measured voltage, an average measured temperature, or subjective data exceeding a predetermined threshold.

[0071] Embodiment 30: The method according to Embodiment 1, further comprising obtaining processed data by processing the data recorded for each treatment location, and simultaneously displaying the processed data for each treatment location.

[0072] Embodiment 31: The method according to Embodiment 1, wherein the at least one treatment site selected to further deliver the tumor treatment site to the subject includes a primary treatment site and a secondary treatment site.

[0073] Embodiment 32: A method for a treatment plan for delivering a tumor treatment site to a subject, the method comprising: arranging a plurality of transducers on the subject for each of a plurality of treatment sites, each of which treatment sites includes a plurality of transducer positions for delivering the tumor treatment site to the subject, each transducer being positioned on the subject according to each transducer position for the treatment site; delivering the tumor treatment site to the subject using the transducers; recording data obtained from delivering the tumor treatment site to the subject; and selecting at least one of the treatment sites for further delivering the tumor treatment site to the subject based on the data obtained from delivering the tumor treatment site to the subject.

[0074] Embodiment 33: The method according to Embodiment 32, wherein arranging the plurality of transducers on the subject includes fixing the plurality of transducers to the subject.

[0075] Embodiment 34: The method according to Embodiment 32, wherein arranging the plurality of transducers on the subject includes arranging the plurality of transducers on the subject without fixing the plurality of transducers to the subject.

[0076] Embodiment 35: Apparatus for a treatment plan for delivering a tumor treatment field to a subject, the apparatus comprising: a voltage generator that generates a voltage for delivering the tumor treatment field to the subject via a transducer placed on the subject; one or more sensors that measure at least one parameter relating to delivering the tumor treatment field to the subject; an input device that receives feedback from the subject regarding delivering the tumor treatment field to the subject; a controller comprising one or more processors; a memory accessible to the one or more processors, the memory including a storage memory that, when executed by the one or more processors, causes the controller to operate to instruct the voltage generator to generate a signal for the tumor treatment field until a current measured from delivering the tumor treatment field to the subject reaches a steady state over a predetermined period of time, the memory storing log files for recording information from the one or more sensors and the input device.

[0077] Embodiments shown in any heading or portion of this disclosure may be combined with embodiments shown in the same or other headings or portions of this disclosure, unless otherwise stated herein or unless the context expressly contradicts the description. For example, an embodiment described in dependent claim form with respect to a given embodiment (e.g., a given embodiment described in independent claim form) may be combined with other embodiments (described in independent or dependent claim form).

[0078] Numerous modifications, alterations, and changes are possible to the embodiments described without departing from the scope of the invention as defined in the claims. The invention is not limited to the embodiments described and is intended to have the entire scope as defined by the following claims and their equivalents. [Explanation of symbols]

[0079] 100 ways 102 Step S 104 Step S 105 Step S 106 Step S 108 Step S 110 Step S 112 Step S 114 Step S 200 transducers 202 Electrode elements 204 circuit board 206 Conductive wiring 208 AC Voltage Generator 210 Controller 212 processors 214 memory 216 sensors (multiple sensors possible) 301 Transducer 302 Electrode elements 303 circuit board 304 Conductive wiring 305 Transducer 306 Electrode elements 400 transducers 500 computer devices 501 Input 502 Processors 503 memory 504 Link 505 Output Device

Claims

1. A computer implementation method for a treatment plan for delivering a tumor treatment site to a subject, wherein the method is: Acquiring multiple therapeutic locations for delivering a tumor treatment site to a subject, wherein each therapeutic location includes multiple transducer locations for delivering the tumor treatment site to the subject. For each treatment location, The tumor treatment area is delivered to the subject using a transducer placed on the subject, To record data obtained from delivering the tumor treatment site to the subject, Based on the data recorded from delivering the tumor treatment site to the subject, at least one of the treatment locations is selected to further deliver the tumor treatment site to the subject. A method that includes this.

2. The method according to claim 1, wherein the plurality of treatment locations are generated by a computer implementation method based on at least one medical image of the subject.

3. The method according to claim 1, wherein the plurality of treatment locations are selected from a database of treatment locations based on the attributes of the subject.

4. The method according to claim 1, wherein the tumor treatment area is delivered to each treatment site in approximately 30 minutes to approximately 6 hours.

5. For each treatment site, the tumor treatment field is delivered until at least one measured electrical parameter related to delivering the tumor treatment field to the subject reaches a steady state over a predetermined time period. The method according to claim 1, wherein the at least one measured electrical parameter is current or voltage.

6. The method according to claim 5, wherein the steady state for the measured electrical parameter is reached when the measured electrical parameter remains constant without substantial ringing over a predetermined time period.

7. The method according to claim 5, wherein the steady state for the measured electrical parameters is reached when the measured electrical parameters fall within approximately 0.2% to approximately 2% of a certain value over the predetermined time period.

8. The steady state for the measured electrical parameters is, The measured current stays within a range of approximately 0.02 amperes to approximately 0.2 amperes from a certain value over the predetermined time period, or The method according to claim 5, which is achieved when at least one of the following occurs: the measured voltage falls within approximately 0.02 volts to approximately 0.2 volts from a certain value over the predetermined time period.

9. The method according to claim 1, wherein for each treatment location, the data recorded from delivering the tumor treatment area to the subject includes measured voltage and measured current from delivering the tumor treatment area to the subject.

10. The method according to claim 1, wherein, for each treatment location, the data recorded from delivering the tumor treatment site to the subject includes subjective data obtained from the subject regarding the delivery of the tumor treatment site to the subject.

11. The method according to claim 1, wherein, for each treatment site, the data recorded from delivering the tumor treatment site to the subject includes subjective data relating to the state of the transducer after it has been removed from the subject.

12. The method according to claim 1, further comprising processing the data recorded for each treatment site to obtain processed data, and selecting at least one of the treatment sites for further delivery of the tumor treatment site to the subject, wherein the selection is made based on the processed data.

13. The method according to claim 1, wherein the tumor treatment site is further delivered to the subject over a period of time during which the total dose of the tumor treatment site is received.

14. A method for a treatment plan for delivering a tumor treatment site to a subject, the method being Each of the plurality of treatment locations for delivering the tumor treatment site to a subject, each treatment location includes a plurality of transducer locations for delivering the tumor treatment site to the subject, Placing multiple transducers on the subject, wherein each transducer is positioned on the subject according to its individual transducer position relative to the treatment location, The tumor treatment area is delivered to the subject using the transducer, To record data obtained from delivering the tumor treatment site to the subject, Based on the data obtained from delivering the tumor treatment site to the subject, select at least one of the treatment locations for further delivering the tumor treatment site to the subject. Methods that include...

15. A device for a treatment plan for delivering a tumor treatment site to a subject, wherein the device is A voltage generator that generates a voltage for delivering the tumor treatment field to the subject via a transducer placed on the subject, One or more sensors that measure at least one parameter related to delivering the tumor treatment site to the subject, An input device for receiving feedback from the subject regarding the delivery of the tumor treatment site to the subject, A controller comprising one or more processors and a memory accessible by the one or more processors, the memory storing instructions that, when executed by the one or more processors, cause the controller to operate to instruct the voltage generator to generate a signal for the tumor treatment field until the current measured from the delivery of the tumor treatment field to the subject reaches a steady state over a predetermined period of time. Includes, The memory is a device that stores log files for recording information from one or more sensors and the input device.

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