Composition for stabilizing isothiocyanates

A sulforaphane-fatty acid composition stabilizes sulforaphane for long-term use in various products by using fatty acids, addressing stability issues and enabling high-concentration applications without complex encapsulation or extreme temperatures.

JP7880820B2Active Publication Date: 2026-06-26VIO CHEM AG
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Patent Information

Application Number
JP2022564555
Authority / Receiving Office
JP · JP
Patent Type
Patents
Current Assignee / Owner
Priority Date
2020-06-30
Filing Date
2021-04-21
Publication Date
2026-06-26
Estimated Expiration
2041-04-21

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Abstract

The present invention relates to a stable composition containing an isothiocyanate. The present invention also relates to a method for stabilizing an isothiocyanate. According to the present invention, sulforaphane is stabilized in the presence of a fatty acid. A composition prepared by mixing sulforaphane with a certain amount of a fatty acid or a mixture of fatty acids exhibits a stabilizing effect on residual sulforaphane. It has been found that such a composition can more effectively maintain, i.e., stabilize, sulforaphane, expressed as a weight percent, under certain storage conditions compared to neat sulforaphane. This facilitates the distribution of sulforaphane as an ingredient for industrial use, for example, in the preparation of various products, nutraceuticals, food additives, pharmaceuticals, dietary supplements, cosmetics, etc., for easier and more efficient long-term storage. Complex stabilization techniques, such as encapsulation or complexation, and extremely low temperatures are not required.
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Citation Information

Patent Citations

  • Sulforaphane sunscreen

    CN110585049A

  • Stabilization of sulforaphane

    JP2013531052A

  • Stabilized sulforaphane

    JP2018027956A

  • Protecting a bioactive and / or precursor thereof

    WO2019148250A1