Method for producing 225Ac solution

The two-step solid-phase extraction process using compounds (A) and (B) addresses low purity and solvent inefficiencies in producing 225Ac, resulting in high-purity solutions suitable for radiopharmaceuticals.

JP7888459B2Active Publication Date: 2026-07-13NIHON MEDI PHYSICS CO LTD
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Patent Information

Application Number
JP2022536364
Authority / Receiving Office
JP · JP
Patent Type
Patents
Current Assignee / Owner
Priority Date
2020-07-17
Filing Date
2021-07-13
Publication Date
2026-07-13
Estimated Expiration
2041-07-13

AI Technical Summary

Technical Problem

Conventional methods for producing 225Ac solutions suffer from low purity due to the presence of significant amounts of 226Ra, require large amounts of solvent, and are inefficient in separating and purifying 225Ac, leading to challenges in solvent usage and Ra recovery.

Method used

A method involving two-step solid-phase extraction using specific compounds represented by formulas (A) and (B) to selectively retain and elute 225Ac ions, reducing solvent use while achieving high purity.

Benefits of technology

This method enables the production of high-purity 225Ac solutions with reduced solvent consumption, suitable for applications in radiopharmaceuticals by minimizing contamination from Ra and its daughter nuclides.

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Abstract

This method for producing a 225Ac solution comprises steps (I)-(III).　In step (I), a solution (1) containing 226Ra and 225Ac is passed through a solid-phase extractant (a) containing a compound represented by formula (A), and 225Ac is held in the solid-phase extractant (a). In step (II), a liquid, which contains an eluate (2) obtained by eluting the held 225Ac from the solid-phase extractant (a), is passed through a solid-phase extractant (b) containing a compound represented by formula (B), and 225Ac is held in the solid-phase extractant (b). In step (III), the held 225Ac is eluted from the solid-phase extractant (b) to obtain a 225Ac solution. (A) [m and n are each independently 0 or 1, and R1-R4 are each independently a C8-C12 alkyl group.] (B) [R5-R6 are each independently a C8 alkyl group or a C8 alkoxy group.]
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Citation Information

Patent Citations

  • Methods for Purifying 225ac from Irradiated 226ra Targets

    JP2009527731A

  • Separation of protactinum, actinium, and other radionuclides from proton irradiated thorium target

    US20150292061A1

  • METHOD FOR PURIFYING 226Ra-CONTAINING SOLUTION, METHOD FOR PRODUCING 226Ra TARGET AND METHOD FOR PRODUCING 225Ac

    WO2021002275A1