Biomarkers and methods for predicting premature birth
A biomarker panel using specific proteins and peptides in biological samples accurately predicts preterm birth, allowing for timely clinical interventions and reducing complications.
JP7888772B2Active Publication Date: 2026-07-13SERA PROGNOSTICS INC
Patent Information
- Application Number
- JP2025011253
- Authority / Receiving Office
- JP · JP
- Patent Type
- Patents
- Current Assignee / Owner
- Priority Date
- 2013-12-20
- Filing Date
- 2025-01-27
- Publication Date
- 2026-07-13
- Estimated Expiration
- 2034-03-14
AI Technical Summary
Technical Problem
Current strategies for identifying women at risk of preterm birth are inadequate, only identifying a small percentage of women who may deliver prematurely, necessitating a more reliable method for early risk assessment and management.
Method used
A panel of biomarkers, including specific proteins and peptides, is used to detect measurable features in biological samples to predict the probability of preterm birth, employing methods such as mass spectrometry and predictive models to calculate a risk score.
Benefits of technology
The biomarker panel provides high sensitivity and specificity in predicting preterm birth, enabling timely clinical management and reducing complications through early identification of at-risk pregnant women.
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Smart Images
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Abstract
To provide biomarker panels, methods and kits for determining the probability for preterm birth in a pregnant female.SOLUTION: The present disclosure is based, in part, on the discovery that certain proteins and peptides in biological samples obtained from a pregnant female are differentially expressed in pregnant females that have an increased risk of developing preterm birth in the future or presently suffering from preterm birth relative to matched controls. The present disclosure is further based, in part, on the unexpected discovery that panels combining one or more of these proteins and peptides can be utilized in methods of determining the probability for preterm birth in a pregnant female with relatively high sensitivity and specificity.SELECTED DRAWING: None
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Citation Information
Patent Citations
Identification and quantification of biomarkers to assess the risk of premature birth.
JP2010534341A
Biomarkers and parameters for hypertensive disorders of pregnancy
US20120142559A1