Adhesive sheets and poultices

Abstract

The present invention discloses an adhesive sheet comprising a support layer, an adhesive layer laminated on the support layer, and a release liner provided on the side of the adhesive layer opposite to the support layer, wherein the adhesive layer contains water, a neutralized polyacrylic acid product, and a methyl acrylate / 2-ethylhexyl acrylate copolymer resin emulsion, with the content of the methyl acrylate / 2-ethylhexyl acrylate copolymer resin emulsion being 1.5% to 15% by mass based on the total mass of the adhesive layer, and the support layer is made of a rayon pulp nonwoven fabric having a maximum load point of 8N or more and an elongation at the breaking point of 40%GL or less.

Description

[Technical Field]

[0001] The present invention relates to adhesive sheets, and more particularly to water-containing adhesive sheets and poultices. [Background technology]

[0002] A water-containing adhesive sheet is manufactured by spreading an adhesive layer on a support layer such as cloth. In addition to water, the adhesive layer contains water-soluble polymers such as gelatin, polyacrylic acid, neutralized polyacrylic acid, and polyvinyl alcohol to ensure shape retention and cohesiveness.

[0003] Poultices are a type of adhesive patch manufactured by spreading a drug-containing adhesive layer on a support layer such as cloth. Generally, the adhesive layer has a high water content and contains water-soluble polymers such as gelatin, polyacrylic acid, neutralized polyacrylic acid, and polyvinyl alcohol.

[0004] Patent Document 1 proposes a poultice that is less likely to peel off even when applied for a long time, and that further reduces the pain caused when it is removed. [Prior art documents] [Patent Documents]

[0005] [Patent Document 1] Japanese Patent Publication No. 2019-156736 [Overview of the project] [Problems that the invention aims to solve]

[0006] In developing adhesive sheets and poultices for use wrapped around fingers or wrists, the inventors discovered that conventional poultices have insufficient adhesion, which can cause the adhesive layer to peel off the skin and / or support layer to which it is applied.

[0007] The present invention has been made in view of the problems of the prior art described above, and aims to provide an adhesive sheet and a poultice to which the adhesive layer does not easily peel off the skin and / or support layer when used wrapped around a finger or wrist. [Means for solving the problem]

[0008] As a result of diligent research to achieve the above objective, the present inventors have discovered that by providing an adhesive sheet and a poultice comprising a support layer made of rayon pulp nonwoven fabric having predetermined physical properties, and an adhesive layer containing water, polyacrylic acid neutralized product, and methyl acrylate / 2-ethylhexyl acrylate copolymer resin emulsion, and by setting the content of methyl acrylate / 2-ethylhexyl acrylate copolymer resin emulsion within a predetermined range, it is possible to provide an adhesive sheet and a poultice in which the adhesive layer is less likely to peel off from the skin or support layer even when wrapped around a finger or wrist, etc., thus completing the present invention.

[0009] In other words, the present invention includes the following [1] to [4]. [1] An adhesive sheet comprising a support layer, an adhesive layer laminated on the support layer, and a release liner provided on the side opposite to the support layer relative to the adhesive layer, wherein the adhesive layer contains water, a neutralized polyacrylic acid product, and a methyl acrylate / 2-ethylhexyl acrylate copolymer resin emulsion, with the content of the methyl acrylate / 2-ethylhexyl acrylate copolymer resin emulsion being 1.5% to 15% by mass based on the total mass of the adhesive layer, and the support layer is made of a rayon pulp nonwoven fabric having a maximum load point of 8N or more and an elongation at the breaking point of 40%GL or less. [2] The adhesive sheet according to [1], wherein the support layer is made of a rayon pulp nonwoven fabric having a maximum load point of 8N or more and 30N or less and an elongation at the breaking point of 30%GL or more and 40%GL or less. [3] A poultice comprising a support layer, an adhesive layer laminated on the support layer, and a release liner provided on the side opposite to the support layer relative to the adhesive layer, wherein the adhesive layer contains a drug, water, a polyacrylic acid neutralized product, and a methyl acrylate / 2-ethylhexyl acrylate copolymer resin emulsion, with the content of the methyl acrylate / 2-ethylhexyl acrylate copolymer resin emulsion being 1.5% to 15% by mass based on the total mass of the adhesive layer, and the support layer is made of a rayon pulp nonwoven fabric having a maximum load point of 8N or more and an elongation at the breaking point of 40%GL or less. [4] The poultice according to [3], wherein the support layer is made of a rayon pulp nonwoven fabric having a maximum load point of 8N or more and 30N or less and an elongation at the breaking point of 30%GL or more and 40%GL or less. [Effects of the Invention]

[0010] According to the present invention, it is possible to provide an adhesive sheet and a poultice to which the adhesive layer is difficult to peel off from the skin and / or support layer when used wrapped around a finger or wrist. [Modes for carrying out the invention]

[0011] Preferred embodiments of the present invention will be described in detail below.

[0012] An adhesive sheet according to the first embodiment of the present invention comprises a support layer, an adhesive layer laminated on the support layer, and a release liner provided on the side of the adhesive layer opposite to the support layer.

[0013] The support layer is made of a rayon pulp non-woven fabric having a maximum load point of 8 N or more and a breaking point elongation of 40% GL or less. The rayon pulp non-woven fabric is a non-woven fabric made of composite fibers obtained by mixing rayon fibers and pulp. The maximum load point and the breaking point elongation mean the measured values when a strip-shaped test piece with a length of 100 mm and a width of 20 mm is fixed to a tensile testing machine so that the chuck distance is 60 mm and measured at a tensile speed of 300 [mm / min]. More specifically, it means the measured value when measured under the apparatus and conditions described in the examples. The rayon pulp non-woven fabric preferably has a maximum load point of 8 N or more and 30 N or less and a breaking point elongation of 30% GL or more and 40% GL or less, and more preferably has a maximum load point of 9 N or more and 27 N or less and a breaking point elongation of 31% GL or more and 36% GL or less. The % GL of the breaking point elongation means % gauge length, that is, the ratio to the distance between punctuation marks.

[0014] The thickness of the rayon pulp non-woven fabric can be 0.1 mm to 1 mm, and may be 0.3 mm to 0.7 mm or 0.4 mm to 0.6 mm.

[0015] The basis weight of the rayon pulp non-woven fabric is 20 g / m 3 ~100 g / m 2 and can be 30 g / m 2 ~90 g / m 2 or 40 g / m 2 ~80 g / m 2 and may be acceptable.

[0016] The lower limit value of the density of the rayon pulp non-woven fabric may be 0.05 g / cm 3 or more, may be 0.12 g / cm 3 or more, may be 0.14 g / cm 3 or more. On the other hand, the upper limit value of the density of the rayon pulp non-woven fabric may be 0.50 g / cm 3 or less, may be 0.30 g / cm 3 or less, may be 0.20 g / cm 3 or less. The density of the rayon pulp non-woven fabric may be 0.05 g / cm 3 ~0.50 g / cm 3 or may be 0.12 g / cm3 ~0.30g / cm 3 But often, 0.14 g / cm³ 3 ~0.20 g / cm³ 3 However, this is also acceptable. By setting the density within this range, the maximum load point and the elongation at the fracture point can be kept within the above range.

[0017] In rayon pulp nonwoven fabrics, the weight ratio of rayon to pulp tends to increase the strength of the support structure, i.e., the point of maximum load rises, as the weight ratio of pulp increases. Conversely, the weight ratio of rayon tends to decrease the strength of the support structure, i.e., the point of maximum load falls.

[0018] The material of the release liner is not particularly limited, and liners made of materials generally known to those skilled in the art can be used. Examples of release liner materials include polyethylene, polypropylene, polybutylene, polyethylene terephthalate, rayon, polyurethane, and paper. These materials may be used individually or in combination of two or more. Polypropylene film is preferred as the material for the release liner.

[0019] The adhesive layer contains water, a neutralized polyacrylic acid, and a copolymer resin emulsion of methyl acrylate and 2-ethylhexyl acrylate.

[0020] The water content in the adhesive layer can be 30% to 70% by mass, based on the total mass of the adhesive layer, and may also be 40% to 60% by mass, or 45% to 55% by mass.

[0021] The polyacrylic acid neutralized product may be a fully neutralized polyacrylic acid, a partially neutralized polyacrylic acid, or a mixture thereof. Examples of polyacrylic acid neutralized products include polyacrylate salts, such as sodium salts, potassium salts, calcium salts, and ammonium salts. A partially neutralized polyacrylic acid product is one in which structural units derived from acrylic acid and structural units derived from acrylate salts are present in any proportion in a single polymer chain. It is preferable to use a partially neutralized polyacrylic acid product in which 50 mol% of the carboxyl groups in a single polymer chain are neutralized, or 35 mol% are neutralized, or both. The content of the polyacrylic acid neutralized product in the adhesive layer can be 2% to 15% by mass, 3% to 10% by mass, or 3% to 5% by mass, based on the total mass of the adhesive layer.

[0022] Methyl acrylate / 2-ethylhexyl acrylate copolymer resin emulsion is an emulsion (aqueous emulsion) in which methyl acrylate / 2-ethylhexyl acrylate copolymer resin is dispersed in water. The content of methyl acrylate / 2-ethylhexyl acrylate copolymer resin in the emulsion can be 55% to 65% by mass based on the total mass of the emulsion. The emulsion may also contain an emulsifier, such as polyoxyethylene nonylphenyl ether. The content of the emulsifier can be 1% to 5% by mass based on the total mass of the emulsion. The content of methyl acrylate / 2-ethylhexyl acrylate copolymer resin emulsion in the adhesive layer is 1.5% to 15% by mass (corresponding to 0.825% to 9.75% by mass as methyl acrylate / 2-ethylhexyl acrylate copolymer resin) based on the total mass of the adhesive layer, preferably 2% to 14% by mass (corresponding to 1.1% to 9.1% by mass as methyl acrylate / 2-ethylhexyl acrylate copolymer resin), and more preferably 3% to 13% by mass (corresponding to 1.65% to 8.45% by mass as methyl acrylate / 2-ethylhexyl acrylate copolymer resin). Examples of commercially available methyl acrylate / 2-ethylhexyl acrylate copolymer resin emulsions include Nikazol TS-620 (trade name, manufactured by Nippon Carbide Industries, Ltd.) and BPW HW-2 (trade name, manufactured by Toyo Chem Co., Ltd.).

[0023] The adhesive layer may also contain other components such as water-soluble polymers (excluding polyacrylic acid neutralized products; the same applies hereinafter), cooling agents, solubilizers, crosslinking agents, fillers, humectants, stabilizers, preservatives, chelating agents, colorants, fragrances, pH adjusters, etc.

[0024] The water-soluble polymer is not particularly limited as long as it can retain moisture in the adhesive layer, and those generally known to those skilled in the art can be used. Examples of water-soluble polymers include gelatin, polyacrylic acid, polyvinyl alcohol, polyvinylpyrrolidone, sodium alginate, hydroxypropyl cellulose, sodium carboxymethylcellulose (carmellose sodium), methylcellulose, and carrageenan. The polyvinyl alcohol may be fully saponified, intermediately saponified, partially saponified, or low-saponified, with intermediate or partially saponified being preferred, and partially saponified being more preferred. The water-soluble polymer may be used alone or in combination of two or more. It is preferable to include at least one selected from the group consisting of gelatin, polyacrylic acid, and partially saponified polyvinyl alcohol as the water-soluble polymer, and it is more preferable to include gelatin, polyacrylic acid, and partially saponified polyvinyl alcohol. If the adhesive layer contains a water-soluble polymer, its content may be 5% to 15% by mass, or 7% to 12% by mass or 8% to 10% by mass, based on the total mass of the adhesive layer.

[0025] Examples of cooling agents include l-menthol, thymol, l-isopulegol, and peppermint oil. Cooling agents may be used individually or in combination of two or more. If the adhesive layer contains a cooling agent, its content may be 0.5% to 1.5% by mass, based on the total mass of the adhesive layer.

[0026] The solubilizer is not particularly limited as long as it can dissolve the drug, and examples include crotamiton; N-methylpyrrolidone; polyalkylene glycols such as polyethylene glycol (PEG) and polybutylene glycol; oxyalkylene fatty acid esters such as polyethylene glycol monostearate; polyoxyalkylene sorbitan fatty acid esters such as polysorbate 80; sorbitan fatty acid esters such as sorbitan monooleate; and surfactants such as polyoxyethylene hydrogenated castor oil. These solubilizers may be used individually or in combination of two or more. If the adhesive layer contains a solubilizer, its content may be 0.1% to 5% by mass, 0.5% to 3% by mass, or 1% to 3% by mass, based on the total mass of the adhesive layer.

[0027] The crosslinking agent is a component used to adjust the progress of the crosslinking reaction between polyacrylic acid neutralized products and the crosslinking reaction between polyacrylic acid neutralized products and optionally added polyacrylic acid. Crosslinking agents commonly used in adhesive sheets can be used. Examples of crosslinking agents include aluminum compounds (magnesium aluminometasilicate, potassium aluminum sulfate (alum), etc.). If the adhesive layer contains a crosslinking agent, its content can be 0.05% to 1% by mass, or 0.1% to 0.7% by mass or 0.2% to 0.5% by mass, based on the total mass of the adhesive layer.

[0028] Examples of fillers include inorganic fillers such as anhydrous silicic acid, titanium dioxide, synthetic aluminum silicate, kaolin, talc, bentonite, and magnesium aluminometasilicate, and may be one of these or a combination of two or more. If the adhesive layer contains a filler, its content may be 0.1% to 1.5% by mass, or 0.2% to 1% by mass or 0.3% to 0.7% by mass, based on the total mass of the adhesive layer.

[0029] The humectant is not particularly limited as long as it can suppress the evaporation of moisture from the adhesive layer over time. Examples of humectants include polyhydric alcohols such as glycerin, sorbitol, ethylene glycol, 1,4-butanediol, and polyethylene glycol. These humectants may be used individually or in combination of two or more. Preferably, the humectant contains at least one selected from the group consisting of glycerin and sorbitol, and more preferably contains both glycerin and sorbitol. If the adhesive layer contains a humectant, its content can be 15% to 45% by mass, 20% to 40% by mass, or 20% to 30% by mass, based on the total mass of the adhesive layer.

[0030] Examples of stabilizers include oxybenzone, dibutylhydroxytoluene (BHT), sodium edetate, and UV absorbers (e.g., dibenzoylmethane derivatives). If the adhesive layer contains a stabilizer, its content may be 0.05% to 1% by mass, 0.1% to 0.6% by mass, or 0.2% to 0.6% by mass, based on the total mass of the adhesive layer.

[0031] Examples of preservatives include methyl parahydroxybenzoate, ethyl parahydroxybenzoate, propyl parahydroxybenzoate, butyl parahydroxybenzoate, 1,2-pentanediol, benzoic acid and its salts, salicylic acid and its salts, sorbic acid and its salts, dehydroacetic acid and its salts, 4-isopropyl-3-methylphenol, 2-isopropyl-5-methylphenol, phenol, hinokitiol, cresol, 2,4,4'-trichloro-2'-hydroxydiphenyl ether, 3,4,4'-trichlorocarbanilide, chlorobutanol, benzalkonium chloride, and benzethonium chloride. These preservatives may be used individually or in combination of two or more. If the adhesive layer contains a preservative, its content may be 0.01% to 1% by mass, 0.05% to 0.5% by mass, or 0.1% to 0.2% by mass, based on the total mass of the adhesive layer.

[0032] Examples of chelating agents include EDTA (also known as ethylenediaminetetraacetic acid) or its salts, ascorbic acid, pyrophosphates, hexametaphosphates, glucons, etc. These chelating agents may be used individually or in combination of two or more. More specifically, sodium edetate is an example of an EDTA salt. If the adhesive layer contains a chelating agent, its content may be 0.05% to 1% by mass, 0.1% to 0.6% by mass, or 0.2% to 0.6% by mass, based on the total mass of the adhesive layer.

[0033] The total mass of the adhesive layer is 200 g / m². 2 ~1000g / m 2 It can be made to 400g / m 2 ~1000g / m 2 It may also be 400g / m 2 ~650g / m 2 That's fine.

[0034] The adhesive layer may further contain a drug. In this specification, an adhesive sheet in which the adhesive layer contains a drug is specifically referred to as a poultice.

[0035] The drugs are not particularly limited as long as they are absorbed through the skin. Examples of drugs include nonsteroidal anti-inflammatory drugs or their esters such as indomethacin, felbinac, flurbiprofen, diclofenac, diclofenac sodium, methyl salicylate, glycol salicylate, and ketoprofen; antihistamines such as diphenhydramine; analgesics such as aspirin, acetaminophen, ibuprofen, and loxoprofen sodium; local anesthetics such as lidocaine; muscle relaxants such as succinylcholine chloride; antifungal agents such as clotrimazole; antihypertensive agents such as clonidine; vasodilators such as nitroglycerin and isosorbide dinitrate; vitamins such as vitamin A, vitamin E (tocopherol), tocopherol acetate, vitamin K, octotiamine, and riboflavin butyrate; prostaglandins; scopolamine, fentanyl, capsicum extract, l-menthol, dl-camphor, and nonyl vanillylamide. Some drugs have two optical isomers, R-isomers and S-isomers. The drug used in this embodiment may be either one optical isomer or a mixture of the two optical isomers in any proportion. The drug may also be in the form of a pharmaceutically acceptable salt. Examples of pharmaceutically acceptable salts include inorganic base salts such as sodium salts, potassium salts, and calcium salts; organic base salts such as amine salts such as monoethanolamine and diethanolamine; inorganic acid salts such as hydrochloride, nitrate, and phosphate; and organic acid salts such as acetate, lactate, benzenesulfonate, and citrate.

[0036] The amount of drug contained in the adhesive layer should be sufficient to allow the drug to exert its therapeutic effect, and this varies depending on the type of drug. For example, based on the total mass of the adhesive layer, glycol salicylate can be present in an amount of 1% to 3% by mass, and l-menthol can be present in an amount of 0.5% to 1.5% by mass.

[0037] The poultice contains an adhesive layer comprising a drug, water, glycerin, D-sorbitol, polyacrylic acid neutralized, methyl acrylate / 2-ethylhexyl acrylate copolymer resin emulsion, gelatin, polyacrylic acid, partially saponified polyvinyl alcohol, sodium edetate, magnesium aluminometasilicate, and l-menthol. Based on the total mass of the adhesive layer, the drug is 0.3% to 2% by mass, water is 40% to 55% by mass, glycerin is 18% to 22% by mass, and D-sorbitol is 3% to 7% by mass. Preferably, the polyacrylic acid neutralized product is 3% to 5% by mass, the methyl acrylate / 2-ethylhexyl acrylate copolymer resin emulsion is 3% to 13% by mass, the gelatin is 1% to 5% by mass, the polyacrylic acid is 1% to 5% by mass, the partially saponified polyvinyl alcohol is 1% to 5% by mass, the sodium edetate is 0.2% to 0.6% by mass, the magnesium aluminometasilicate is 0.2% to 0.5% by mass, and the l-menthol is 0.5% to 1.5% by mass.

[0038] The application sites for adhesive sheets and poultices are not particularly limited, but examples include the neck, shoulders, upper arms, forearms, fingers, or wrists. Because the adhesive layer is less likely to peel off the skin or support layer even when wrapped around fingers or wrists, they are particularly suitable for use on fingers or wrists. In particular, when used on fingers, adhesive sheets and poultices longer than the circumference of the finger may be wrapped around the finger, and the adhesive layer may overlap the support layer attached to the skin. Even in such cases, the adhesion of the overlapping portion is sufficient, so it will not peel off even after being attached for a long time, making it particularly suitable for use on fingers.

[0039] Adhesive sheets and poultices can be manufactured, for example, by mixing water, polyacrylic acid neutralized, methyl acrylate / 2-ethylhexyl acrylate copolymer resin emulsion (and in the case of poultices, additional drugs as well), and optionally the above-mentioned optional components to obtain an adhesive composition, uniformly spreading this adhesive composition onto a release liner, and laminating a support layer thereon. Alternatively, adhesive sheets and poultices may be manufactured by uniformly spreading the adhesive composition onto a support layer and laminating a release liner thereon. [Examples]

[0040] Adhesive compositions were prepared by mixing the components shown in the examples and comparative examples in Tables 1, 3, and 5 below (the numerical values ​​for each component in the table represent mass %). Then, the resulting adhesive composition was prepared so that the adhesive layer mass per unit area was 500 g / m². 2 To achieve this, the material is uniformly spread on a release liner (polypropylene film), and a nonwoven fabric support layer is laminated on top of it, for a total length of 35 cm. 2 (7cm x 5cm; for fingers) or 70cm 2 The poultices were obtained by cutting the material to a size of 14cm x 5cm (for the wrist). The methyl acrylate / 2-ethylhexyl acrylate copolymer emulsion used was Nikazol TS-620 (trade name, manufactured by Nippon Carbide Industries, Ltd., methyl acrylate / 2-ethylhexyl acrylate copolymer content: 58% by mass based on the total mass of the emulsion), the aminoalkyl methacrylate copolymer E used was Eudragit EPO (trade name, manufactured by Rohm Co., Ltd.), and the butyl methacrylate / methyl methacrylate copolymer used was Plastoid B (trade name, manufactured by Rohm Co., Ltd.). In addition, the concentrated glycerin and D-sorbitol solution used were those listed in the Japanese Pharmacopoeia (18th edition of the Japanese Pharmacopoeia).

[0041] Each poultice was applied to the fingers (middle or ring finger) or wrists of eight subjects, and adhesion, stickiness, residue, pain upon removal, leakage, and liner removal were evaluated using the following methods. The evaluation results are summarized in Tables 2, 4, and 6.

[0042] Evaluation when applied to the finger <Adhesion> The release liner was peeled off the poultice and applied to the subject's finger (middle or ring finger). Immediately after bending and straightening the finger 40 times and after predetermined time intervals (8, 16, and 24 hours), the adhesion of the adhesive layer to the skin and the adhesion of the overlapping portion of the adhesive layer and the support layer were scored according to the following criteria. The average score of the subjects was used as the evaluation result, and a score (average) of 3.5 or higher (adhesion of the adhesive layer to the skin) and 4.5 or higher (adhesion of the overlapping portion of the adhesive layer and the support layer) were judged as acceptable. 6: No peeling 5: Peeling at the edges (less than 1 / 4 of the adhesive surface is peeled off) 4: Peeling of 1 / 4 to less than 1 / 3 of the adhesive surface. 3: Peeling of 1 / 3 to less than 1 / 2 of the adhesive surface. 2: Peel off more than half of the adhesive surface. 1: Falling off

[0043] <Stickiness> The release liner was removed from the poultice and applied to the subject's finger (middle or ring finger). After 24 hours, the degree of stickiness of the skin where the adhesive had been applied was scored according to the following criteria. The average score of the subjects was used as the evaluation result, and a score (average) of 3.0 or higher was considered acceptable. 4: Non-sticky 3: Not very sticky 2: Slightly sticky (no problem in terms of use) 1: Sticky (problematic in use)

[0044] <Ointment residue> The release liner was removed from the poultice and applied to the subject's finger (middle or ring finger). After 24 hours, the degree to which the adhesive layer remained on the skin where the adhesive had been applied was scored according to the following criteria. The average score was used as the evaluation result, and a score (average) of 3.0 or higher was considered acceptable. 4: No plaster residue remaining 3: Residual amount that is not noticeable (residual on one or more sides but less than two sides of the adhesive layer) 2: Residual adhesive layer on 2 or more sides but less than 4 sides 1: Residual adhesive on all four sides of the adhesive layer or inside the adhesive surface

[0045] <Pain during peeling> The release liner was removed from the poultice and applied to the subject's finger (middle or ring finger). After 24 hours, the pain experienced when removing the poultice from the skin was scored according to the following criteria. The average score was used as the evaluation result, and a score (average) of 3.0 or higher was considered acceptable. 4: No pain 3: Not noticeable (no problem in use) 2: Slightly painful 1: It hurts

[0046] <Staining> The release liner was removed from the poultice and applied to the subject's finger (middle or ring finger). After 24 hours, the area where the adhesive layer had seeped onto the support layer of the poultice after it had peeled off the skin was measured and scored according to the following criteria. The average score was used as the evaluation result, and a score (average) of 4.0 or higher was deemed acceptable. 5: No bleeding 4: Slight bleeding (area: less than 10%) 3: Slight bleeding (area: 10% to less than 20%) 2: Significant bleeding (area: 20% to less than 30%) 1: Significant bleeding (area: 30% or more)

[0047] <Liner peeling> The ease of peeling off the release liner from the poultice was scored by the subjects according to the following criteria. The average score was used as the evaluation result, and a score (average) of 2.0 to 4.0 was judged as acceptable. 5: Light 4: Slightly light 3: Just right 2: Slightly heavy 1: Heavy

[0048] Evaluation when applied to the wrist <Adhesion (wrist)> The release liner was peeled off the poultice and applied to the subject's wrist. The adhesion of the adhesive layer to the skin was scored according to the following criteria immediately after the subject bent and straightened their wrist 40 times and again after predetermined time intervals (8, 16, and 24 hours). The average score of the subjects was used as the evaluation result, and a score (average) of 3.5 or higher was judged as acceptable. 6: No peeling 5: Peeling at the edges (less than 1 / 4 of the adhesive surface is peeled off) 4: Peeling of 1 / 4 to less than 1 / 3 of the adhesive surface. 3: Peeling of 1 / 3 to less than 1 / 2 of the adhesive surface. 2: Peel off more than half of the adhesive surface. 1: Falling off

[0049] Stickiness, ointment residue, pain upon removal, leakage, and liner removal were evaluated in the same way as when the patch was applied to a finger.

[0050] The maximum load point and elongation at the breaking point of the support were measured using the following method. The support was punched out into strip-shaped test pieces measuring 100 mm in length and 20 mm in width. The testing machine (Tensilon Tensile Tester RTA-100; manufactured by A&D Co., Ltd.) was set to a distance of 60 mm between the chucks and set as the starting point. The upper end of the test piece was clamped in the upper chuck and fixed. The test piece was pulled by hand to the extent that there was no slack, and the lower end was clamped in the lower chuck and fixed. A load was applied at a tensile speed of 300 mm / min until the test piece broke. The strength at the maximum load point (maximum load point) and elongation at the maximum load point (elongation at the breaking point) of the test piece were measured. Three measurements were taken for each test piece, and the average value was taken as the maximum load point and elongation at the breaking point of the support.

[0051] [Table 1]

[0052] [Table 2]

[0053] In Example 1, the poultice, which used a methyl acrylate / 2-ethylhexyl acrylate copolymer resin emulsion as the adhesive base, exhibited sufficient adhesion, whereas in Comparative Examples 1 and 2, which used other acrylic adhesive bases, the adhesion was insufficient.

[0054] [Table 3]

[0055] [Table 4]

[0056] In Examples 1 to 3, the poultices containing methyl acrylate / 2-ethylhexyl acrylate copolymer resin emulsion in the range of 1.5% to 15% by mass exhibited sufficient adhesion. In contrast, in Comparative Examples 3 to 5, the poultices containing methyl acrylate / 2-ethylhexyl acrylate copolymer resin emulsion outside this range experienced problems with adhesion, pain upon removal, or stickiness.

[0057] [Table 5]

[0058] [Table 6]

[0059] In Examples 1, 4-6, the poultices, which had a support layer made of rayon pulp nonwoven fabric with a maximum load point of 8N or more and an elongation at the breaking point of 40%GL or less, exhibited sufficient adhesion. In contrast, the poultices of Comparative Examples 6 and 7, which had a support layer made of PET nonwoven fabric or rayon nonwoven fabric, and the poultices of Comparative Examples 8 and 9, which had a support layer made of rayon pulp nonwoven fabric with a maximum load point of less than 8N or an elongation at the breaking point of 40%GL, exhibited insufficient adhesion.

[0060] Furthermore, poultices were prepared in the same manner as in Example 1, except that diclofenac sodium (1.0% by mass), ketoprofen (0.3% by mass), felbinac (0.7% by mass), or flurbiprofen (0.33% by mass) were used instead of glycol salicylate and l-menthol (Examples 7-10, in order). Adhesive sheets were prepared in the same manner as in Example 1, except that glycol salicylate and l-menthol were excluded (Example 11). The poultices of Examples 7-10 and the adhesive sheet of Example 11 were evaluated in the same manner, and all showed good results in all evaluation items.

Claims

1. Support layer and An adhesive layer laminated on the support layer, A release liner is provided on the side of the adhesive layer opposite to the support layer, Equipped with, The adhesive layer contains water, a neutralized polyacrylic acid product, and a copolymer resin emulsion of methyl acrylate and 2-ethylhexyl acrylate. Based on the total mass of the adhesive layer, the content of the methyl acrylate / 2-ethylhexyl acrylate copolymer resin emulsion is 1.5% to 15% by mass. The support layer is made of a rayon pulp nonwoven fabric having a maximum load point of 8 N or more and an elongation at the breaking point of 40% GL or less. Adhesive sheet.

2. The adhesive sheet according to claim 1, wherein the support layer is made of a rayon pulp nonwoven fabric having a maximum load point of 8 N or more and 30 N or less and an elongation at the breaking point of 30% GL or more and 40% GL or less.

3. A poultice comprising a drug further contained in the adhesive layer of the adhesive sheet according to claim 1 or 2.

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