Pen-type diagnostic microneedle device

Abstract

The present invention comprises: a body portion capable of being grasped by hand and capable of moving a movable member formed inside by pressing a protruding part on the upper side up and down; and a detection portion comprising a pain-reducing member that forms an empty space inside and forms negative pressure upon contact with the skin, and a microneedle member located inside the pain-reducing member and coupled with the movable member to move up and down so as to be able to contact the skin; wherein the microneedle, having an absorption tube formed inside the microneedle member, is capable of diagnosis by minimally invasively invading the skin while the pain-reducing member forms negative pressure upon contact with the skin and applying negative pressure to the skin.

Description

Technology Field

[0001] The present invention relates to a pen-type diagnostic microneedle device that enables diagnosis by inserting microneedles located at the lower part into the skin to collect interstitial fluid when the user presses the upper part like a pen while holding it in their hand. Background Technology

[0003] Detecting biological signs in vitro and in vivo can provide real-time detection of physiologically relevant compounds, such as for the monitoring of metabolites, electrolytes, biochemicals, neurotransmitters, medically relevant molecules, cancer biomarkers, and pathogenic microorganisms. Devices that perform the detection of these biological signs are known as biosensors, which can provide real-time detection of physiological substances and processes of living organisms. A biosensor is an analytical tool capable of detecting chemicals or organisms by utilizing a biologically sensitive component coupled with transducing elements to convert the detected signs into signals for processing and / or display. Biosensors may use biological materials as the biologically sensitive component, such as living cells, as well as biomolecules including enzymes, antibodies, and nucleic acids. For example, molecular biosensors may be configured to identify target agents using specific chemical properties or molecular recognition mechanisms. Examples may include drug discovery and drug screening, as well as evaluating physiological and pathological activities within tissues. Biosensors may utilize a transducer element to convert a signal obtained from the detection of an analyte by a biologically responsive component into a different signal that can be addressed by optical, electronic, or other means.For example, transduction mechanisms may include physicochemical, electrochemical, optical, piezoelectric, and other transduction means.

[0004] Among these, there is a diagnostic method based on physicochemical techniques that involves collecting interstitial fluid from the body using a needle for examination. However, this method presents complex challenges, such as difficulties in collecting interstitial fluid with disposable syringes and the requirement to perform diagnosis using diagnostic kits.

[0005] Therefore, the industry is currently conducting continuous and active research and development to address the shortcomings of the method of simply collecting interstitial fluid and diagnosing it using a diagnostic kit.

[0006] The technology forming the background of the present invention is disclosed in Korean Published Patent Application No. 10-2022-0019607 (February 17, 2022). The problem to be solved

[0008] The present invention was created to solve the problems of the prior art described above and to expand the scope of application. The objective of the present invention is to provide a microneedle device that enables diagnosis by minimizing skin irritation through the collection of interstitial fluid via the microneedle after the microneedle device has stimulated the skin by forming negative pressure. means of solving the problem

[0010] The present invention comprises: a body portion capable of being grasped by hand and capable of moving a movable member formed inside by pressing a protruding portion on the upper side up and down; and a detection portion comprising a pain-reducing member that forms an empty space inside and forms negative pressure upon contact with the skin, and a microneedle member located inside the pain-reducing member and coupled with the movable member to move up and down so as to be able to contact the skin; wherein, while the pain-reducing member is in contact with the skin, negative pressure is formed and applied to the skin, and a microneedle having an absorption tube formed inside the microneedle member allows for diagnosis through minimal invasiveness to the skin.

[0011] Specifically, the pain-reducing member is formed to be integral with or detachable from the body part, and can block airflow from the outside when an open hole formed on the lower side comes into contact with the skin.

[0012] Specifically, the microneedle member may include: a microneedle that moves together with the fluid member when the fluid member moves upward or downward; and a housing having a height shorter than that of the microneedle and having an insertion hole formed therein that is spaced apart from at least a portion so that the microneedle can be inserted.

[0013] Specifically, the microneedle member comprises: a base portion formed so as to be integrally formed or coupled with the microneedle; and a spring located between the base portion and the housing and providing elastic force in the opposite direction of movement when the base portion moves downward; wherein the spring can provide elastic force so that when the movable member moves upward, the microneedle is separated from the skin and inserted into the housing.

[0014] Specifically, the microneedles are formed of a porous material so that when inserted into the skin, interstitial fluid diffuses inward, and the microneedle member includes a detection absorption layer formed to be in contact with at least a portion of the microneedles to absorb the interstitial fluid, and the detection absorption layer can diagnose through the interstitial fluid.

[0015] Specifically, the body portion may include a display member that displays the diagnosis performed by the micro-member.

[0016] Specifically, the body portion may include a support member that can be grasped by hand and can be combined with or integrally formed with the pain relief member, and a movable member formed on the inner side of the support member, having an outer surface formed identically to that of the support member, and capable of moving downward by an external force.

[0017] Specifically, the body portion may include an elastic member that provides an upward elastic force to a fluid member that moves downward by the external force. Effects of the invention

[0019] The microneedle device of the present invention has the effect of minimizing skin irritation when the microneedle is inserted by forming negative pressure upon contact with the skin and providing slight skin stimulation.

[0020] The interstitial fluid is also protected from external contaminants as the microneedles are located inside the housing.

[0021] In addition, it has the effect of allowing interstitial fluid to be collected by pressing the upper side while the user holds it, and enabling simple diagnosis through the internal diagnostic kit. Brief explanation of the drawing

[0023] FIG. 1 is a schematic diagram showing the overall shape of a microneedle device according to an embodiment of the present invention. FIG. 2 is a schematic diagram showing an example of use of a microneedle device according to an embodiment of the present invention. FIG. 3 is a schematic diagram showing an example of a microneedle according to an embodiment of the present invention. FIG. 4 is a schematic diagram showing an enlarged detection unit according to an embodiment of the present invention. Specific details for implementing the invention

[0024] The objects, specific advantages, and novel features of the present invention will become more apparent from the following detailed description and preferred embodiments in conjunction with the accompanying drawings. It should be noted that in assigning reference numerals to the components of each drawing in this specification, the same components are assigned the same number whenever possible, even if they are shown in different drawings. Furthermore, in describing the present invention, detailed descriptions of related prior art are omitted if it is determined that such detailed descriptions would unnecessarily obscure the essence of the invention.

[0026] The following detailed description will be provided in conjunction with the drawings shown below.

[0028] FIG. 1 is a schematic diagram showing the overall shape of a microneedle device (1) according to an embodiment of the present invention, and FIG. 2 is a schematic diagram showing an example of use of a microneedle device (1) according to an embodiment of the present invention.

[0030] The microneedle device (1) of the present invention, with reference to FIGS. 1 and 2, may be capable of enabling diagnosis by inserting a microneedle (2230) formed on the lower side into the skin (S) after gripping it with a hand and pressing the upper side, thereby collecting interstitial fluid.

[0032] Specifically, the device comprises: a body part (10) that can be grasped by hand and can move a movable member (130) formed inside by pressing a protruding part on the upper side up and down; and a detection part including a pain relief member (210) that forms an empty space inside and contacts the skin (S) to form negative pressure, and a microneedle member (220) that is located inside the pain relief member (210) and is coupled with the movable member (130) to move up and down so as to be able to contact the skin (S); and a diagnosis can be made by minimally invading the skin (S) with a microneedle (2230) in which an absorption tube (2231) is formed inside the microneedle member (220) while the pain relief member (210) is in contact with the skin (S) to form negative pressure and apply negative pressure to the skin (S).

[0033] Here, the body portion (10) may be formed as a hollow cylinder. It may have a length in the cylindrical direction, and the circumference of the cylinder may be of a size that can be grasped. For example, it may be formed to have a diameter of 5 cm or less. A movable member (130) may be formed inside this body portion (10). The movable member (130) may be formed such that at least a portion protrudes upward and can move up and down when the protruding portion is pressed by an external force.

[0034] The detection unit (20) of the present invention may include a pain-reducing member (210) and a microneedle member (220). The pain-reducing member (210) may be formed by being coupled to the lower side of the body part (10) and may have an empty space formed inside. The parts of this pain-reducing member (210), excluding the opening hole (2110) formed on the lower side, may be closed to block the airflow between the inside and outside when in contact with the skin (S). That is, when the opening hole (2110) comes into close contact with the skin (S), the inside may be formed with negative pressure to stimulate the skin (S). For example, similar to cupping, the skin (S) may be pulled upward as the inside is formed with negative pressure. As described above, the skin (S) pulled by the pain-reducing member (210) can increase interstitial fluid, and when the micro-needle (2230) described later is inserted into the skin (S), it has the effect of reducing pain.

[0035] Additionally, the microneedle member (220) of the present invention may be located inside the pain relief member (210). This may be intended to reduce pain by inserting the microneedle member (220) into the skin (S) while the skin (S) is stimulated by being pulled upward using the pain relief member (210). This microneedle member (220) is formed to be combined with the previously described fluid member (130), and a microneedle (2230) is formed on the lower side, and when the fluid member (130) moves downward, the microneedle (2230) moves downward and is inserted into the skin (S) to perform interstitial fluid collection.

[0037] Specifically, the pain-reducing member (210) of the present invention is formed to be integral with or detachably attached to the body part (10), and can block airflow from the outside when the open hole (2110) formed on the lower side comes into contact with the skin (S).

[0038] The pain-reducing member (210) of the present invention may be formed in combination with the fluid member (130) as described above. At this time, the combination may be formed integrally or may be formed to be detachable. For example, referring to FIG. 2, the microneedle member (220) formed inside the pain-reducing member may be located only inside the pain-reducing member (210) (the fluid member (130) and the pain-reducing member (210) are separable), or the microneedle member (220) may be formed extending outside the pain-reducing member (210) (the pain-reducing member (210) and the fluid member (130) are formed integrally).

[0039] The microneedle member (220) of the present invention may be formed to be replaceable after use. In this case, when the microneedle member (220) and the pain relief member (210) are formed integrally, only the microneedle (2230) and the detection absorption layer (2250) described later may be replaced, but is not limited thereto, and the entire microneedle member (220) may be replaced. Additionally, when the microneedle member (220) and the pain relief member (210) are formed to be separable, the entire microneedle member (220) may be replaced, or only the lower part may be replaced, among other selective applications.

[0040] This pain-reducing member (210) may have an open hole (2110) formed therein, and the portion excluding the open hole (2110) may have a closed shape. That is, when the microneedle member (220) is positioned in the pain-reducing member (210), the inside of the pain-reducing member (210) may be isolated from the outside when negative pressure is formed through internal finishing. Additionally, as previously described, the open hole (2110) may be designed to cause the pain-reducing member (210) to close when in close contact with the skin (S). In this way, when an external force is continuously applied while the pain relief member (210) is closed internally, the open hole (2110) at the bottom is in close contact with the skin (S), and the skin (S) is pushed into the pain relief member (210), causing the internal volume to decrease and the external force to be removed. Then, the skin (S) that has been pushed in forms a negative pressure, which may perform the function of pulling the skin (S) like a cupping therapy.

[0042] FIG. 3 is a schematic diagram showing an example of a microneedle (220) according to an embodiment of the present invention.

[0044] The microneedle member (220) of the present invention, with reference to FIG. 3, may include: a microneedle (2230) formed in a double structure that moves together with the movable member (130) when the latter moves upward or downward; and a housing (2240) having a height shorter than that of the microneedle (2230) and having an insertion hole (2241) formed therein that is spaced apart from at least a portion so that the microneedle (2230) can be inserted.

[0045] The microneedle (2230) of the present invention may have a length in the downward direction and may have a pointed portion formed therein. Since the microneedle (2230) is coupled when the fluid member (130) moves downward, it may be formed to move downward together with the fluid member (130) and be inserted into the skin (S) inside the pain relief member (210). The microneedle (2230) inserted into the skin (S) may be formed so that interstitial fluid can flow along the microneedle (2230). It may perform the role of delivering interstitial fluid to the detection absorption layer (2250) described later, and as another example, the inside of the microneedle (2230) may be provided in a hollow shape to contain interstitial fluid.

[0046] The housing (2240) of the present invention may be formed to allow a microneedle (2230) to pass through. Specifically, it may include an open hole (2110) having an open shape in which the area where the microneedle (2230) is located is open. This open hole (2110) protects the microneedle (2230) located inside and prevents the insertion of secondary external contaminants, such as hair, by allowing the microneedle (2230) to be located inside the housing (2240) after interstitial fluid collection, thereby enabling the acquisition of only pure interstitial fluid required for diagnosis.

[0047] This housing (2240) may have a longer length than the microneedle (2230). Specifically, it may have a longer length in the vertical direction. This is to ensure that the microneedle (2230) is fully inserted into the housing (2240), and that the fully inserted microneedle (2230) is protected from external contaminants.

[0048] The microneedle (2230) of the present invention may include an absorption tube (2231). The absorption tube (2231) may be formed inside the microneedle (2230). Additionally, the cross-section may be formed in a circular shape and, having a very small width, interstitial fluid may be rapidly collected along the absorption tube (2231) due to capillary action while the microneedle (2230) is inserted into the skin (S). Such an absorption tube (2231) may be formed in each microneedle (2230).

[0050] According to one embodiment of the present invention, the microneedle member (220) comprises: a base portion (2210) formed integrally with or capable of being coupled to the microneedle (2230); and a spring (2220) located between the base portion (2210) and the housing (2240) and providing elastic force in the opposite direction of movement when the base portion (2210) moves downward. The spring (2220) can provide elastic force so that when the movable member (130) moves upward, the microneedle (2230) is separated from the skin (S) and inserted into the housing (2240).

[0051] Here, the base (2210) may be a wide plate shape for fixing the microneedle (2230). That is, the base (2210) is connected to the movable member (130), so that when the movable member (130) moves up and down, the base (2210) moves together with it, and the microneedle (2230) fixed to the base (2210) can move up and down.

[0052] A spring (2220) may be formed on the lower side of the base (2210). For example, the spring (2220) may be located between the base (2210) and the housing (2240) area, excluding the location of the insertion hole (2241). The spring (2220) may provide elastic force in the vertical direction, and due to this elastic force, the base (2210) and the housing (2240) can maintain a certain distance. Here, the certain distance may be a distance that allows the microneedle (2230) to be fully inserted into the housing (2240). Specifically, the spring (2220) located between the base (2210) and the housing (2240) may be partially compressed by an external force applied to the fluid member (130) and then restored to its original state, thereby maintaining a certain distance between the base (2210) and the housing (2240).

[0053] An example of operation of the microneedle member (220) according to the embodiment described above will be explained. The microneedle member (220) includes a base (2210), a housing (2240), a spring (2220), and a microneedle (2230). When an external force is applied from the upper side to the lower side, the housing (2240) first comes into contact with the skin (S). When a continuous external force is applied, the spring (2220) is compressed, causing the microneedle (2230) to protrude out of the housing (2240) and be inserted into the skin (S). Additionally, when the collection of interstitial fluid is finished and the external force begins to be removed, the microneedle (2230) is first separated from the skin (S) by the elastic force of the elastic member (140) described later, and then the microneedle (2230) is inserted into the housing (2240) by the spring (2220) to be protected from external contaminants.

[0055] FIG. 4 is a schematic diagram showing an enlarged detection unit (20) according to an embodiment of the present invention.

[0057] A microneedle (2230) according to one embodiment of the present invention with reference to FIG. 4 is formed of a porous material and includes an absorption tube (2231) so that when inserted into the skin (S), the interstitial fluid is diffused into the interior, and the microneedle member (220) includes a detection absorption layer (2250) formed to be in contact with at least a portion of the microneedle (2230) so that the interstitial fluid is absorbed, and the detection absorption layer (2250) can diagnose through the interstitial fluid.

[0058] The microneedle (2230) of the present invention may be inserted into the skin (S) to perform the function of collecting interstitial fluid. To this end, the microneedle (2230) may be formed of a porous material. The porous material may have a very large number of small holes (allowing interstitial fluid to pass through). That is, when the microneedle (2230) is inserted into the skin (S), as previously described, the interior is formed by the pain-reducing member (210), so the interstitial fluid inside the skin (S) exhibits a property of moving from high pressure to low pressure, diffuses along the porous microneedle (2230), and can collect a large amount of interstitial fluid in a short time, but is not limited thereto. According to another embodiment, the microneedle (2230) may be provided with a hollow interior to collect interstitial fluid.

[0059] The detection absorption layer (2250) of the present invention may maintain a state in which at least a portion of it is in contact with the microneedle (2230) so that interstitial fluid diffused into the microneedle (2230) can move to the detection absorption layer (2250), and may perform a diagnosis using the interstitial fluid that has moved to the detection absorption layer (2250). At this time, the detection absorption layer (2250) may perform a diagnosis in various ways. For example, it may perform a diagnosis using the color of the detection absorption layer (2250), and as another example, the detection absorption layer (2250) may measure the blood sugar level and perform a diagnosis as a numerical value.

[0060] The detection absorption layer (2250) described above may be formed integrally with the microneedle (2230) and may maintain contact with at least a portion thereof. Referring to FIG. 4, a spring (2220) may be formed between the base (2210) and the detection absorption layer (2250). This spring (2220) is compressed by an external force, and the distance between the base (2210) and the detection absorption layer (2250) becomes closer. Afterward, when the diagnosis is finished and the external force is removed, the distance between the base (2210) and the detection absorption layer (2250) increases due to the elastic force of the spring (2220). At this time, the base (2210) and the detection absorption layer (2250) may be formed to maintain a certain distance apart or may be formed to be separated. For example, regarding the two situations, if the base (2210) and the detection absorption layer (2250) are formed with a certain gap, when the microneedle member (220) is separated and replaced after diagnosis, the base (2210), spring (2220), microneedle (2230), and spring (2220) may be replaced all at once. That is, the base (2210), spring (2220), microneedle (2230), and spring (2220) are formed as a single unit and replaced, thereby facilitating replacement. Conversely, if the base (2210) and the detection absorption layer (2250) are formed to be separated by more than the above certain distance, only the microneedle (2230) and the detection absorption layer (2250) may be replaced. In this case, wasted materials (spring (2220) and base (2210)) can be minimized.

[0062] According to one embodiment of the present invention, the body portion (10) may include a display member (110) that displays the diagnosis performed by the micro-member.

[0063] The display member (110) of the present invention may display a diagnosis result. For example, in the case of a diagnosis of epilepsy, it may display whether there is an epilepsy infection, and in the case of a diagnosis of diabetes, it may display a blood sugar level.

[0064] Such a display member (110) may be formed on the upper part of the body part (10) and may be formed so that the display member (110) can be viewed from the outside.

[0066] According to one embodiment of the present invention, the body portion (10) may include a support member (120) that can be grasped by hand and can be combined with or integrally formed with the pain relief member (210), and a movable member (130) formed on the inner side of the support member (120), having an outer surface formed identically to the support member (120), and capable of moving downward by an external force.

[0067] The support member (120) of the present invention may be formed to surround the outside of the body part (10). That is, it may be an area that is directly touched by the hand when a user grips it. This support member (120) may be formed of a rigid material so that shape change or movement is restricted even when an external force is applied.

[0068] The fluid member (130) of the present invention may be formed inside the support member (120). This fluid member (130) may be formed to be able to move up and down within the support member (120). That is, the fluid member (130) may be formed to have a diameter smaller than the diameter of the support member (120). The microneedle member (220) described above may be formed to be coupled to the lower side of this fluid member (130). At this time, the pain relief member (210) formed to surround the microneedle member (220) may be formed to be coupled to the support member (120).

[0070] A body portion (10) according to one embodiment of the present invention may include an elastic member (140) that provides an elastic force in the upward direction to a fluid member (130) that moves in the downward direction by the external force.

[0071] According to one embodiment of the present invention, the elastic member (140) may be formed to surround the fluid member (130). That is, the fluid member (130) is formed inside the elastic member (140), and when the fluid member (130) moves downward due to an external force, the elastic member (140) is compressed, and when the external force is removed, the elastic member (140) may provide an elastic force in the upward direction to the fluid member (130).

[0072] At this time, the elastic member (140) may be formed by being coupled to the lower side of the display member (110). The display member (110) may be coupled to the upper side of the movable member (130), and elastic force may be provided to the display member (110) by a spring (2220) located between the display member (110) and the lower side of the movable member (130). This will be explained in detail below in the operation example.

[0074] To explain an example of operation of a microneedle device (1) according to one embodiment of the present invention, the microneedle device (1) contacts a pain-reducing member (210) with the skin (S) while the user is gripping a support member (120), and then applies an additional external force to cause the inside of the pain-reducing member (210) to form negative pressure, thereby creating a negative pressure stimulus on the skin (S) similar to cupping.

[0075] Afterwards, an external force is applied to the upper side of the display member (110) to move the display member (110), the movable member (130), and the microneedle member (220) downwards, and first the elastic member (140) is compressed and moved downwards, after which the housing (2240) comes into contact with the skin (S) and the spring (2220) is compressed and the microneedle (2230) is inserted into the skin (S).

[0076] As the microneedle (2230) is inserted into the skin (S), the interstitial fluid can be collected by rapidly spreading along the microneedle (2230) due to the negative pressure of the pain-reducing member (210) and the porous material of the microneedle (2230).

[0077] The user, having confirmed that the interstitial fluid has been collected, removes the external force, and the microneedle member (220) from which the external force has been removed moves upward by the elastic member (140), the microneedle (2230) is separated from the skin (S), and the microneedle (2230) is inserted into the housing (2240) by the spring (2220).

[0078] Afterwards, when the elastic member (140) is fully unfolded, the interstitial fluid collection is completed, and the infection status or diagnostic value is displayed on the display member (110) by the detection absorption layer (2250).

[0080] Through the above process, the effect is to minimize irritation to the skin (S) (minimizing pain through negative pressure stimulation), enable rapid collection of interstitial fluid (using a microneedle (2230) made of a porous material), and enable immediate diagnosis (using an absorption layer (2250) for detection).

[0082] Although the present invention has been described in detail through specific embodiments, this is for the purpose of specifically explaining the invention, and the invention is not limited thereto. It will be apparent that modifications or improvements can be made by those skilled in the art within the technical scope of the invention.

[0083] All simple variations or modifications of the present invention fall within the scope of the present invention, and the specific scope of protection of the present invention will be clarified by the appended claims. Explanation of the symbols

[0085] 1: Microneedle device 10: Body part 110: Display component 120: Support member 130: Fluid member 140: Elastic member 20: Index finger 210: Absence of pain attenuation 2110: Open Hall 220: Microneedle absence 2210: Base 2220: Spring 2230: Microneedle 2231: Absorption tube 2240: Housing 2241: Insertion hole 2250: Absorbent layer for detection S: Skin

Claims

Claim 1 A pen-type diagnostic microneedle device comprising: a body portion capable of being grasped by hand and capable of moving a fluid member formed inside by pressing a protruding part on the upper side up and down; and a detection portion comprising a pain-reducing member that forms an empty space inside and forms negative pressure upon contact with the skin, and a microneedle member located inside the pain-reducing member and coupled with the fluid member to move up and down so as to be able to contact the skin; wherein the microneedle, having an absorption tube formed inside the microneedle member, is capable of diagnosis by minimally invading the skin while the pain-reducing member forms negative pressure upon contact with the skin and applying negative pressure to the skin. Claim 2 A pen-type diagnostic microneedle device according to claim 1, wherein the pain-reducing member is formed to be integral with or detachably attached to the body part, and is characterized in that when an open hole formed on the lower side comes into contact with the skin, airflow from the outside is blocked. Claim 3 A pen-type diagnostic microneedle device according to claim 1, characterized in that the microneedle member comprises: a microneedle formed in a double structure and moving together with the movable member when the movable member moves upward or downward; and a housing having a height shorter than the microneedle and having an insertion hole formed therein that is spaced apart from at least a portion so that the microneedle can be inserted. Claim 4 In paragraph 3, the microneedle member comprises: a base portion formed such that the microneedle may be integrally formed or coupled thereto; and a spring positioned between the base portion and the housing and providing elastic force in the direction opposite to the direction of movement when the base portion moves downward; wherein the spring provides elastic force such that when the movable member moves upward, the microneedle is separated from the skin and inserted into the housing. This characterizes a pen-type diagnostic microneedle device. Claim 5 A pen-type diagnostic microneedle device according to claim 4, wherein the microneedle is formed of a porous material to allow interstitial fluid to diffuse inward when inserted into the skin, and the microneedle member includes a detection absorption layer formed to be in contact with at least a portion of the microneedle to absorb the interstitial fluid, and the detection absorption layer diagnoses through the interstitial fluid. Claim 6 A pen-type diagnostic microneedle device according to claim 1, wherein the body portion comprises a display member that displays a diagnosis performed by the micro-member. Claim 7 A pen-type diagnostic microneedle device according to claim 6, wherein the body portion comprises a support member that can be grasped by hand and can be combined with or integrally formed with the pain relief member, and a movable member formed on the inner side of the support member, the outer surface of which is formed identically to the support member, and which can move downward by an external force. Claim 8 A pen-type diagnostic microneedle device according to claim 7, wherein the body portion comprises an elastic member that provides an elastic force in the upward direction to a fluid member that moves in the downward direction by the external force.

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