Inverse latex for cosmetic compositions comprising a specific chelating agent and a polymer electrolyte combining a strong acid functional agent and a weak acid functional agent.

Abstract

a) one or more first monomer units derived from 2-methyl-2-[(1-oxo-2-propenyl)amino]-1-propanesulfonic acid in the form of free or partially or fully chlorinated acid; one or more second monomer units derived from one or more monomers selected from the group consisting of acrylic acid, methacrylic acid, 2-carboxyethylacrylic acid, itaconic acid, maleic acid, and 3-methyl-3-[(1-oxo-2-propenyl)amino]butanoic acid (the carboxyl functional groups of said monomers are in the form of free, partially chlorinated or fully chlorinated acid); and - a crosslinked anionic polymer electrolyte (P) comprising one or more third monomer units derived from a polyethylene-based crosslinked monomer (AR); b) a self-reversible inverse latex comprising an aqueous phase containing ethylenediaminedisuccinic acid in the form of a trisodium salt.

Description

Technology Field

[0001] The present invention relates to a self-reversible inverse latex comprising a novel metal ion chelating agent, a method for manufacturing said self-reversible inverse latex, the use of said self-reversible inverse latex as a thickener and / or emulsifier and / or stabilizer in the manufacture of cosmetic or pharmaceutical compositions for topical use, and also said compositions manufactured thus. Background Technology

[0002] Polymers are widely used today in cosmetic formulations for topical use and represent the second most widely used product family in this type of formulation. Cosmetic compositions contain a polar phase, for example, a phase consisting of water, and in most cases, it is necessary to use rheology-modifying polymers to increase the viscosity of this polar phase and also to impart well-defined rheological behavior.

[0003] Among polymers that control the rheology of the polar phase, natural or synthetic polymers, in particular linear or branched, crosslinked or non-crosslinked, anionic or cationic, or amphiphilic polymer electrolyte types, may be mentioned. Once introduced into the polar phase, these polymers have the characteristic of spreading under the influence of electrostatic repulsion due to the presence of (negative and / or positive) charges on the linear or branched, non-crosslinked or crosslinked polymer backbone. The rheology controller provides both an increase in viscosity of the polar phase and a stabilizing effect and / or a certain degree of dominance imparted to cosmetic, dermocosmetic, or dermatological pharmaceutical formulations to be thickened.

[0004] To meet consumer demands and improve cosmetic formulations for topical use, scientists have developed new, innovative, and diverse polymer systems. Accordingly, polymers used in topical cosmetics or dermocosmetics can act as film-forming agents or rheology modifiers, enable the stabilization of fatty phases or particles (pigments or fillers) in emulsions (water-in-oil or water-in-oil types), or otherwise impart specific sensory characteristics (e.g., soft feel, ease of handling and application, freshness effect, etc.) after application to the skin, and also directly influence the appearance of the formulation (translucent or opaque).

[0005] Rheology-controlled polymers for the aqueous phase, primarily polymer electrolytes, are produced from the radical polymerization of (meth)acrylate monomers, namely esters derived from acrylic acid or methacrylic acid, or derivatives of acrylamide.

[0006] Today, these polymers, which can be provided in the form of inverse latex, concentrated inverse latex, or powder, make it possible to meet customer requirements in terms of thickening performance in polar solvents, such as water. Once these polymers are dispersed in water, the resulting aqueous gel has a smooth appearance without granules or lumps, specific sensory characteristics regarding touch, and also ease of handling and application.

[0007] A liquid form or a concentrated liquid form thereof known as "self-reversible inverse latex" is provided in the form of a water-in-oil emulsion and is a composition comprising the following:

[0008] - An aqueous phase comprising one or more polymers of a linear and / or branched and / or cross-linked, anionic, cationic, or amphoteric type of polymer electrolyte,

[0009] - Fatty phase containing one or more oils,

[0010] - One or more water-in-oil type emulsifying surfactants (S1),

[0011] - One or more emulsifying surfactants of the water-in-water type (S2)

[0012] - (The above polymer is obtained by performing a reverse emulsion radical polymerization process).

[0013] Radical polymerization is known to be sensitive to the presence of even small amounts of impurities. Compounds capable of reducing the polymerization rate at low concentrations are known as inhibitors or retarders. However, the distinction between these two effects is not always simple, and the same compound can make both detrimental contributions depending on its concentration within the medium or the properties of the monomer and the reaction medium. It is necessary to ensure the consistent quality of cosmetic formulations for topical use containing such polymers by guaranteeing the reproducible performance of polymers that thicken the aqueous phase. To this end, industrial manufacturers must ensure that the polymerization reaction follows identical kinetics for repeatability—more specifically, with respect to inhibition time, temperature increase profile, and total duration of the polymerization reaction over time. Given these constraints, special attention is paid to factors that may affect the initiation of the radical polymerization reaction, such as the presence of oxygen, which can react with the generated radicals to delay the polymerization reaction. These new peroxide radicals have lower reactivity because their initiation ability is reduced. This is reflected by a weaker initiation phase and a lower propagation rate, ultimately leading to polymers with different thickening characteristics. Therefore, it was found that a step of deoxygenating the medium by purging with nitrogen, particularly before initiating the polymerization reaction, is necessary.

[0014] Another factor that directly affects polymerization is the presence of metal species (Fe2+, Fe3+, Cu2+, etc.), which in turn produces an inhibitory effect. In this case, inhibition can occur due to the reaction between initiator radicals and metal impurities during the initiation phase, preventing the active radical center from anchoring another monomer unit during polymerization, resulting in an inactive state.

[0015] The above metal ions may potentially originate from the starting material or otherwise from items of the equipment.

[0016] The monomers used in the manufacture of self-reversible inverse latex may contain trace amounts of metal cations. In the same way, it is not impossible to imagine the presence of metal contaminants in items of industrial equipment that house polymerization reactants. In most cases, equipment items are made of stainless steel, encountering various types of stainless steel with different compositions. Stainless steel is an iron-based alloy to which nickel, chromium, or molybdenum is added in specific cases. It is chromium that provides the anti-oxidation properties to stainless steel because it can regenerate its surface chromium oxide layer (referred to as the passivation layer) on its own in the presence of oxygen.

[0017] However, in the event of prolonged contact with sources of contaminants, acids, moisture, seawater sprays, or iron-containing dust, or in the case of deep scratches, the protective layer becomes depassivated (and thus activated), and it is not impossible for the stainless steel to oxidize faster than it can protect itself. In such cases, the appearance of rust may be observed, and thus the rust becomes a source of iron-based metal contaminants.

[0018] Given the risks associated with the presence of all these sources of metal contaminants, the use of metal ion chelating agents is inevitable. A commonly used product is the pentasodium salt of diethylenetriamine pentaacetic acid (also known by the brand name Versenex™ 80).

[0019] However, due to changes in European regulations regarding the classification of the pentasodium salt of diethylenetriaminepentaacetic acid, an alternative solution as a metal ion chelating agent for the manufacture of self-reversible inverse latex was sought.

[0020] Starting from there, the problem is to provide a novel inverse latex having a novel metal ion chelating agent that is as effective as the pentasodium salt of diethylenetriamine pentaacetic acid but has properties that are more compliant with changes in regulations.

[0021] One solution of the present invention is a self-reversible inverse latex comprising an aqueous phase comprising the following:

[0022] a)

[0023] - One or more first monomer units produced from 2-methyl-2-[(1-oxo-2-propenyl)amino]-1-propanesulfonic acid in a free acid form or in a partially or completely chlorinated form;

[0024] - One or more second monomer units derived from one or more monomers selected from the group consisting of acrylic acid, methacrylic acid, 2-carboxyethylacrylic acid, itaconic acid, maleic acid, and 3-methyl-3-[(1-oxo-2-propenyl)amino]butanoic acid (the carboxyl functional groups of said monomers are in a free acid form, a partially chlorinated form, or a fully chlorinated form);

[0025] - One or more third monomer units derived from polyethylene-based crosslinked monomers (AR)

[0026] A cross-linked anionic polymer electrolyte (P) composed of

[0027] b) Ethylenediaminedisuccinic acid in the form of a trisodium salt.

[0028] In some cases, the self-reversible inverse latex according to the present invention may have one or more of the following features:

[0029] - The aqueous phase contains 0.01 mol% or more of ethylenediaminedisuccinic acid in the form of a trisodium salt;

[0030] - The polyethylene-based crosslinking monomer (AR) is selected from methylenebis(acrylamide), ethylene glycol dimethacrylate, diethylene glycol diacrylate, ethylene glycol diacrylate, diallylurea, trialylamine, trimethylolpropane triacrylate, diallyloxyacetic acid or a salt thereof, e.g., sodium diallyloxyacetate, or a mixture of these compounds;

[0031] - The crosslinking monomer (AR) is methylenebis(acrylamide) or trialylamine;

[0032] - The cross-linked anionic polymer electrolyte comprises, per 100 mol%: monomer units derived from 2-methyl-2-[(1-oxo-2-propenyl)amino]-1-propanesulfonic acid in a free acid form or in a partially or completely chlorinated form, in a ratio of 20 mol% to 90 mol%, more specifically 32 mol% to 90 mol%, and even more specifically 40 mol% to 80 mol%; A monomer unit derived from one or more monomers selected from the group consisting of acrylic acid, methacrylic acid, 2-carboxyethylacrylic acid, itaconic acid, maleic acid, and 3-methyl-3-[(1-oxo-2-propenyl)amino]butanoic acid, in a ratio of 10 mol% to 80 mol%, more specifically 10 mol% to 68 mol%, even more specifically 20 mol% to 60 mol% (the carboxyl functional groups of said monomers are in a free acid form, a partially chlorinated form, or a fully chlorinated form); and a monomer unit derived from one or more polyethylene-based crosslinked monomers (AR), in a ratio greater than 0 mol% and less than or equal to 1 mol%, more specifically 0.5% or less, more specifically 0.25% or less, most specifically 0.1% or less, more specifically 0.005 mol% or more molar ratio.

[0033] For the purposes of the present invention, the term “crosslinked anionic polymer electrolyte (P)” refers to a nonlinear polymer electrolyte provided in the form of a three-dimensional network, in which the polymer (P) is insoluble in water but can swell in water to obtain a chemical gel.

[0034] For the purposes of the present invention, the term “chlorinated” indicates that the acid functional agent present in the monomer exists in an anionic form combined with a cation and a salt (in particular, alkali metal salts, e.g., sodium or potassium cations, or cations of nitrogenous bases, e.g., ammonium salts, lysine salts, or monoethanolamine salts (HOCH2-CH2-NH3) + This is preferably a sodium or ammonium salt.

[0035] According to a specific embodiment of the present invention, the self-reversible inverse latex as defined above comprises 20 mass% to 90 mass%, and more specifically 30 mass% to 90 mass%, more specifically 30 mass% to 80 mass%, and even more specifically 33 mass% to 80 mass% of the cross-linked anionic polymer electrolyte (P).

[0036] According to another specific aspect of the present invention, the molar ratio of monomer units derived from free acid or partially or completely chlorinated forms of 2-methyl-2-[(1-oxo-2-propenyl)amino]-1-propanesulfonic acid present in the crosslinked anionic polymer electrolyte (P) is 32 mol% or more and 100 mol% or less, more specifically 40 mol% or more and 100 mol% or less.

[0037] According to another specific aspect of the present invention, the crosslinked anionic polymer electrolyte comprises, per 100 mol%: monomer units derived from 2-methyl-2-[(1-oxo-2-propenyl)amino]-1-propanesulfonic acid in a free acid form or in a partially or completely chlorinated form, in a ratio of 20 mol% to 90 mol%, more specifically 32 mol% to 90 mol%, and even more specifically 40 mol% to 80 mol%;

[0038] - One or more second monomer units derived from one or more monomers selected from the group consisting of acrylic acid, methacrylic acid, 2-carboxyethylacrylic acid, itaconic acid, maleic acid, and 3-methyl-3-[(1-oxo-2-propenyl)amino]butanoic acid, in a ratio of 10 mol% to 80 mol%, more specifically 10 mol% to 68 mol%, and even more specifically 20 mol% to 60 mol% (the carboxyl functional groups of said monomers are in a free acid form, a partially chlorinated form, or a fully chlorinated form);

[0039] - Monomer units derived from one or more polyethylene-based crosslinked monomers (AR) in a ratio greater than 0 mol% and less than or equal to 1 mol%, more specifically 0.5 mol% or less, more specifically 0.25 mol% or less, and most specifically 0.1 mol% or less, and more specifically 0.005 mol% or more molar ratio. According to a specific embodiment of the present invention, 2-methyl-2-[(1-oxo-2-propenyl)amino]-1-propanesulfonic acid is in the form of a sodium or ammonium salt.

[0040] According to a specific embodiment of the present invention, acrylic acid is in the form of a sodium or ammonium salt.

[0041] The subject of the present invention is also a method for manufacturing inverse latex as defined above, comprising the following steps:

[0042] a) A step of preparing an aqueous phase as previously defined,

[0043] b) a step of preparing an organic phase comprising one or more oils (O) and a water-in-oil type emulsifying surfactant system (S1),

[0044] c) a step of mixing and emulsifying the aqueous phase and organic phase prepared in steps a) and b) to form an emulsion,

[0045] d) a step of inactivating the emulsion with nitrogen,

[0046] e) a step of introducing a free radical initiator into an inactivated emulsion to initiate a polymerization reaction, and

[0047] f) a step of introducing an aqueous-type emulsifying surfactant system (S2) into the reaction medium produced from step e) at a temperature of 30°C to 60°C.

[0048] In some cases, the method according to the present invention may have one or more of the following features:

[0049] - The present method comprises the step of adding a solution selected from sodium hydroxide solution, potassium hydroxide solution, ammonium hydroxide solution, monoethanolamine salt solution, and lysine salt solution to the aqueous phase prepared in step a) between step a) and step b);

[0050] - In step e), the radical initiator is hydrogen sulfite (HSO3 - ) A redox pair that generates ions, e.g., cumene hydroperoxide / sodium metabisulfite (Na2S2O5) pair or cumene hydroperoxide / thionyl chloride (SOCl2) pair;

[0051] - In step e), a polymerization initiator, preferably azobis(isobutyronitrile), is introduced into the inactivated emulsion;

[0052] - In step a), the pH of the aqueous phase is adjusted to 3.0 to 7.0, more specifically to 3.5 to 6.5, and even more specifically to 4.0 to 6.5;

[0053] - The reaction medium generated from step e) is concentrated by distillation before performing step f);

[0054] - The reaction medium generated from step e) or f) is spray-dried.

[0055] The term "oil (O)" specifically, in the definition of the self-reversible inverse latex above, indicates the following:

[0056] - Linear alkanes containing 11 to 19 carbon atoms;

[0057] - Branched alkanes comprising 7 to 40 carbon atoms, such as isododecane, isopentadecane, isohexadecane, isoheptadecane, isooctadecane, isononadecane or isoeicosan, or mixtures of some of these, such as those mentioned below and identified by INCI names: C7-8 isoparaffin, C8-9 isoparaffin, C9-11 isoparaffin, C9-12 isoparaffin, C9-13 isoparaffin, C9-14 isoparaffin, C9-16 isoparaffin, C10-11 isoparaffin, C10-12 isoparaffin, C10-13 isoparaffin, C11-12 isoparaffin, C11-13 isoparaffin, C11-14 isoparaffin, C12-14 Isoparaffin, C12-20 isoparaffin, C13-14 isoparaffin, C13-16 isoparaffin;

[0058] - Cycloalkanes selectively substituted with one or more linear or branched alkyl radicals;

[0059] - White mineral oils, e.g., products sold under the following names: Marcol™ 52, Marcol™ 82, Drakeol™ 6VR, Eolane™ 130, Eolane™ 150;

[0060] - Hemisqualane (or 2,6,10-trimethyldodecane; CAS No.: 3891-98-3), squalane (or 2,6,10,15,19,23-hexamethyltetracosan), hydrogenated polyisobutene or hydrogenated polydecene;

[0061] - A mixture of alkanes comprising 15 to 19 carbon atoms (the alkanes being linear alkanes, branched alkanes, and cycloalkanes), and more specifically, a mixture (M1) comprising, with respect to 100% by weight, a branched alkane in a weight ratio of 90% or more and 100% or less; a linear alkane in a weight ratio of 0% or more and 9% or less, and more specifically less than 5%; and a cycloalkane in a weight ratio of 0% or more and 1% or less, for example, a mixture sold under the designation Emogreen™ L15 or Emogreen™ L19;

[0062] - Fatty alcohol ether of chemical formula IV:

[0063] [Chemical Formula IV]

[0064] Z1-O-Z2

[0065] - (wherein Z1 and Z2 may be the same or different and represent a linear or branched alkyl radical comprising 5 to 18 carbon atoms, e.g., dioctyl ether, didecyl ether, didodecyl ether, dodecyl octyl ether, dihexadecyl ether, (1,3-dimethylbutyl) tetradecyl ether, (1,3-dimethylbutyl) hexadecyl ether, bis(1,3-dimethylbutyl) ether or dihexyl ether);

[0066] - Monoester of a fatty acid and an alcohol of chemical formula V:

[0067] [Chemical Formula V]

[0068] R'1-(C=O)-O-R'2

[0069] (Here, R'1-(C=O) represents a saturated or unsaturated, linear or branched acyl radical containing 8 to 24 carbon atoms, and R'2, independently of R'1, represents a saturated or unsaturated, linear or branched hydrocarbon chain containing 1 to 24 carbon atoms, e.g., methyl laurate, ethyl laurate, propyl laurate, isopropyl laurate, butyl laurate, 2-butyl laurate, hexyl laurate, methyl cocoate, ethyl cocoate, propyl cocoate, isopropyl cocoate, butyl cocoate, 2-butyl cocoate, hexyl cocoate, methyl myristate, ethyl myristate, propyl myristate, isopropyl myristate, butyl myristate, 2-butyl myristate, hexyl myristate, octyl myristate, methyl Palmitate, Ethyl Palmitate, Propyl Palmitate, Isopropyl Palmitate, Butyl Palmitate, 2-Butyl Palmitate, Hexyl Palmitate, Octyl Palmitate, Methyl Oleate, Ethyl Oleate, Propyl Oleate, Isopropyl Oleate, Butyl Oleate, 2-Butyl Oleate, Hexyl Oleate, Octyl Oleate, Methyl Stearate, Ethyl Stearate, Propyl Stearate, Isopropyl Stearate, Butyl Stearate, 2-Butyl Stearate, Hexyl Stearate, Octyl Stearate, Methyl Isostearate, Ethyl Isostearate, Propyl Isostearate, Isopropyl Isostearate, Butyl Isostearate, 2-Butyl Isostearate, Hexyl Isostearate, Isostearyl Represents isostearate);

[0070] - Diesters of fatty acids of formula VI and VII and glycerol:

[0071] [Chemical Formula VI]

[0072] R'3-(C=O)-O-CH2-CH(OH)-CH2-O-(C=O)-R'4

[0073] [Chemical Formula VII]

[0074] R'5-(C=O)-O-CH2-CH[O-(C=O)-R'6]-CH2-OH

[0075] (In Formulas VI and VII, R'3-(C=O), R'4-(C=O), R'5-(C=O) and R'6-(C=O) may be the same or different and represent a saturated or unsaturated, linear or branched acyl group comprising 8 to 24 carbon atoms);

[0076] - Triester of fatty acid and glycerol of chemical formula VIII:

[0077] [Chemical Formula VIII]

[0078] R'7-(C=O)-O-CH2-CH[O-(C=O)-R''8]-CH2-O-(C=O)-R''9

[0079] (Here, R'7-(C=O), R'8-(C=O) and R'9-(C=O) may be the same or different and represent a saturated or unsaturated, linear or branched acyl group containing 8 to 24 carbon atoms).

[0080] According to another specific aspect of the present invention, the oil (H) is a mixture of undecane, tridecane, isododecane and isohexadecane, alkanes and isoalkanes and cycloalkanes, e.g., a mixture (M1) as previously defined and a mixture sold under the names Emogreen™L15, Emogreen™L19, Emosmart™L15, Emosmart™L19, Emosmart™V21, Isopar™L or Isopar™M; a white mineral oil sold under the names Marcol™52, Marcol™82, Drakeol™6VR, Eolane™130 or Eolane™150; hemisqualane, squalane, hydrogenated polyisobutene or hydrogenated polydecene; dioctyl ether or didecyl ether; It is selected from isopropyl myristate, hexyl palmitate, octyl palmitate, isostearyl isostearate, octanoyl / decanoyl triglyceride, hexadecanoyl / octadecanoyl triglyceride, and triglycerides derived from rapeseed oil, sunflower oil, flaxseed oil, or palm oil.

[0081] In the self-reversible inverse latex that is the subject of the present invention, the water-in-oil emulsion system (S1) is composed of either a single emulsion surfactant or a mixture of emulsion surfactants, provided that the resulting emulsion system (S1) has a sufficiently low HLB value to cause the formation of a water-in-oil emulsion.

[0082] Examples of water-in-oil type emulsifying surfactants (S1) include an anhydrohexitol ester of a linear or branched, saturated or unsaturated aliphatic carboxylic acid having 12 to 22 carbon atoms, optionally substituted with one or more hydroxyl groups, and more specifically, an anhydrohexitol ester selected from anhydrosorbitol and anhydromannitol, and a linear or branched, saturated or unsaturated aliphatic carboxylic acid having 12 to 22 carbon atoms, optionally substituted with one or more hydroxyl groups.

[0083] According to another specific aspect of the present invention, the water-in-oil type emulsion system (S1) comprises sorbitan laurate (e.g., product sold under the name Montane™ 20), sorbitan palmitate (e.g., product sold under the name Montane™ 40), sorbitan stearate (e.g., product sold under the name Montane™ 60), sorbitan oleate (e.g., product sold under the name Montane™ 80), sorbitan sesquioleate (e.g., product sold under the name Montane™ 85), sorbitan trioleate (e.g., product sold under the name Montane™ 83), sorbitan isolaurate, sorbitan isostearate (e.g., product sold under the name Montane™ 70), mannitan laurate, mannitan oleate, and a mixture of esters thereof; Polyesters having a molecular weight of 1,000 to 3,000 and derived by condensation between polyisobutenyl succinic acid or its anhydride, e.g., Hypermer™ 2296, or mixtures sold under the brand name Simaline™ IE 501A, polyglycol polyhydroxystearate of formula IX:

[0084] [Chem 1]

[0085] [Chemical Formula IX]

[0086]

[0087] (In Formula IX, y2 represents an integer greater than or equal to 2 and less than or equal to 50, Z4 represents a hydrogen atom, a methyl radical, or an ethyl radical, and Z3 represents a radical of Formula X:

[0088] [Chem 2]

[0089] [Chemical Formula X]

[0090]

[0091] (In chemical formula X, y'2 represents an integer greater than or equal to 0 and less than or equal to 10, more specifically greater than or equal to 1 and less than or equal to 10), Z'3 represents a radical of chemical formula X as defined above (where Z3' is the same as or different from Z3), or a hydrogen atom)

[0092] It is selected from the elements of a group consisting of.

[0093] Examples of water-in-oil type emulsifying surfactants of formula IX that can be used to manufacture an emulsifying system (S1) include PEG-30 dipolyhydroxystearate sold under the name Simaline™ WO, or a mixture of PEG-30 dipolyhydroxystearate sold under the names Simaline™IE 201 A and Simaline™IE 201 B, or a mixture of trimethylolpropane-30 tripolyhydroxystearate sold under the name Simaline™IE 301 B.

[0094] According to a specific embodiment of the present invention, an underwater type emulsification system (S2) comprises a composition (Ce) in a ratio of at least 50 mass% and no more than 100 mass% per 100% of mass, and said composition (Ce) per 100% of mass

[0095] At least one compound of Formula I, in an amount of 10 to 60 mass%, more specifically 15 to 60 mass%, and most specifically 15 to 50 mass%:

[0096] [Chemical Formula I]

[0097] HO-[CH2-CH(OH)-CH2-O]nH

[0098] (Here, n represents an integer greater than or equal to 1 and less than or equal to 15);

[0099] At least one compound of Formula II, 40 mass% to 90 mass%, more specifically 40 mass% to 85 mass%, and most specifically 50 mass% to 85 mass%:

[0100] [Chemical Formula II]

[0101] R1-(C=O)-[O-CH2-CH(OH)-CH2]p-OH

[0102] (wherein p is different from or the same as n and represents an integer greater than or equal to 1 and less than or equal to 15; group R1-(C=O)- represents a saturated or unsaturated, linear or branched aliphatic radical containing 6 to 22 carbon atoms); and optionally

[0103] At least one composition (C11) represented by Formula III, 30 mass% or less, more specifically 0 mass% to 25 mass%, and most specifically 0 mass% to 20 mass%:

[0104] [Chemical Formula III]

[0105] HO-[CH2-CHOH-CH2-O-]q-(G)rH

[0106] (Here, q is different from or identical to n and represents an integer greater than or equal to 1 and less than or equal to 3, G represents a reducing sugar residue, and r represents a decimal greater than or equal to 1.05 and less than or equal to 5.00)

[0107] Including;

[0108] The above composition (C11) is composed of a mixture of compounds of chemical formulas III1, III2, III3, III4, and III5 corresponding to a1, a2, a3, a4, and a5, respectively, wherein the sum (a1 + a2 + a3 + a4 + a5) is 1 and the sum (a1 + 2a2 + 3a3 + 4a4 + 5a5) is r in molar ratios:

[0109] [Chemical Formula III1]

[0110] HO-[CH2-CHOH-CH2-O-]q -O-(G)1-H

[0111] [Chemical Formula III2]

[0112] HO-[CH2-CHOH-CH2-O-]q -O-(G)2-H

[0113] [Chemical Formula III3]

[0114] HO-[CH2-CHOH-CH2-O-]q -O-(G)3-H

[0115] [Chemical Formula III4]

[0116] HO-[CH2-CHOH-CH2-O-]q -O-(G)4-H

[0117] [Chemical Formula III5]

[0118] HO-[CH2-CHOH-CH2-O-]q -O-(G)5-H.

[0119] The water-in-oil type emulsion system (S2) is composed of either the composition (Ce) alone or a mixture of the composition (Ce) and one or more other emulsifying surfactants, provided that the resulting emulsion system (S2) has a sufficiently high HLB value to form a water-in-oil type emulsion.

[0120] The term "reducing sugar" refers to a sugar derivative that does not have in its structure an established glycosidic bond between the anomeric carbon and the oxygen of the acetal group, as defined in reference ["Biochemistry", Daniel Voet / Judith G. Voet, p. 250, John Wiley & Sons, 1990] in Chemical Formula III as previously defined. oligomeric structure (G) x It can exist in any isomer form, regardless of whether it is an optical isomer, geometric isomer, or positional isomer, and can also represent a mixture of isomers.

[0121] In relation to the polymerization reaction, this is initiated at a preferential temperature of 10°C in step e), and then carried out semi-adiabatically or by controlling the temperature up to a temperature of 50°C or higher.

[0122] The subject of the present invention is also the use of the self-reversible inverse latex as previously defined as a thickener and / or emulsifier and / or stabilizer for topical cosmetic or pharmaceutical compositions.

[0123] The subject of the present invention is also a topical cosmetic composition (F) or a topical pharmaceutical composition (G) characterized by comprising, as a thickener, 0.1 mass% to 10 mass% of the self-reversible inverse latex as previously defined, per 100% of total mass.

[0124] The term “topical” used in the definitions of the above compositions (F) and (G) means that the composition is used by application to the skin, hair, scalp, or mucous membranes, whether the application relates to direct application in the case of cosmetics, dermocosmetics, dermatological pharmaceuticals, or pharmaceutical formulations, or indirect application in the case of body care products in the form of fabrics or paper wipes, for example, or hygiene products intended to come into contact with the skin or mucous membranes.

[0125] The above compositions (F) and (G) are generally provided in the form of aqueous or aqueous / alcoholic or aqueous / glycol solutions, or in the form of suspensions, emulsions, microemulsions or nanoemulsions, regardless of whether they are water in oil, oil in water, water in oil in water, or water in oil in oil type.

[0126] The above compositions (F) and (G) may be packaged in a bottle, in a "pump-action spray" type device, in a pressurized form in an aerosol device, in a device with perforated walls such as a grate, or in a device with a ball applicator (known as "roll-on").

[0127] Generally, the compositions (F) and (G) also include excipients and / or active principles commonly used in topical formulations, particularly in cosmetic, dermocosmetic, pharmaceutical or dermatological formulations, such as thickening and / or gelling surfactants, stabilizers, film-forming compounds, hydrotropic agents, plasticizers, emulsifiers and co-forming agents, opacifiers, pearlescent agents, superfatting agents, metal ion chelating agents, chelating agents, antioxidants, fragrances, preservatives, conditioning agents, whitening agents intended for bleaching body hair and skin, active ingredients intended to contribute to therapeutic action on skin or hair, sunscreens, pigments or mineral fillers, particles intended to provide visual effects or encapsulate active ingredients, exfoliating particles or texturing agents.

[0128] Examples of foaming and / or detergent surfactants that can be combined with the self-reversible inverse latex as previously defined in compositions (F) and (G) include anionic, cationic, amphoteric, or nonionic foaming and / or detergent surfactants.

[0129] Foaming and / or detergent anionic surfactants that may be combined with the self-reversible inverse latex as previously defined in compositions (F) and (G) include alkyl ether sulfates, alkyl sulfates, alkylamido ether sulfates, alkylaryl polyether sulfates, monoglyceride sulfates, α-olefin sulfonates, paraffin sulfonates, alkyl phosphates, alkyl ether phosphates, alkyl sulfonates, alkylamide sulfonates, alkylaryl sulfonates, alkyl carboxylates, alkyl sulfosuccinates, alkyl ether sulfosuccinates, alkylamide sulfosuccinates, alkyl sulfoacetates, alkyl sarcosinates, acyl isethionates, N-acyl taurates, acyl lactylates, N-acyl amino acid derivatives, N-acyl peptide derivatives, N-acyl protein derivatives, and N-acyl fatty acids. Derivatives include alkali metal salts, alkaline earth metal salts, ammonium salts, amine salts, or amino alcohol salts.

[0130] Foaming and / or detergent amphoteric surfactants that can be combined with the self-reversible inverse latex as previously defined in compositions (F) and (G) include alkyl betaine, alkyl amido betaine, sultane, alkyl amidoalkyl sulfobetaine, imidazoline derivatives, phosphobetaine, amphopolyacetate, and amphopropionate.

[0131] Foaming and / or detergent cationic surfactants that can be combined with the self-reversible inverse latex as previously defined in compositions (F) and (G) include, in particular, quaternary ammonium derivatives.

[0132] Foaming and / or detergent nonionic surfactants that can be combined with the self-reversible inverse latex as previously defined in compositions (F) and (G) more specifically include: alkyl polyglycosides comprising linear or branched and saturated or unsaturated aliphatic radicals comprising 8 to 16 carbon atoms, such as octyl polyglucoside, decyl polyglucoside, undecylenyl polyglucoside, dodecyl polyglucoside, tetradecyl polyglucoside, hexadecyl polyglucoside, or 1,12-dodecanediyl polyglucoside; ethoxylated hydrogenated castor oil derivatives, such as products sold under the INCI name "PEG-40 hydrogenated castor oil"; polysorbates, such as polysorbate 20, polysorbate 40, polysorbate 60, polysorbate 70, polysorbate 80, or polysorbate 85; Coconut kernel amide; or N-alkylamine is included.

[0133] Examples of thickening and / or gelling surfactants that may be combined with the self-reversible inverse latex as previously defined in compositions (F) and (G) include optionally alkoxylated alkyl polyglycosidic fatty esters, such as ethoxylated methyl polyglycosidic esters, e.g., PEG 120 methyl glucose trioleate and PEG 120 methyl glucose dioleate sold under the names Glucamate™ LT and Glucamate™ DOE-120, respectively; alkoxylated fatty esters, such as PEG 150 pentaerythrityl tetrastearate sold under the name Crothix™ DS53 or PEG 55 propylene glycol oleate sold under the name Antil™ 141; Fat-chain polyalkylene glycol carbamates include, for example, PPG-14 laureth isophoryl dicarbamate sold under the name Elfacos™ T211 or PPG-14 palmes-60 hexyl dicarbamate sold under the name Elfacos™ GT2125.

[0134] Examples of thickening and / or gelling agents that may be combined with the self-reversible inverse latex as previously defined in compositions (F) and (G) include a copolymer of AMPS and alkyl acrylate (its carbon chain comprising 4 to 30 carbon atoms, more specifically 10 to 30 carbon atoms), at least one monomer having a free, partially chlorinated, or fully chlorinated strong acid functional group, at least one neutral monomer, and a linear, branched, or cross-linked terpolymer of at least one monomer of formula XIII:

[0135] [Chemical Formula XIII]

[0136] CH2=C(R'3)-C(=O)-[CH2-CH2-O]n'-R'4

[0137] (Here, R'3 represents a hydrogen atom or a methyl radical, R'4 represents a linear or branched alkyl radical containing 8 to 30 carbon atoms, and n' represents a number greater than or equal to 1 and less than or equal to 50) is included.

[0138] Examples of thickening and / or gelling agents that may be combined with the self-reversible inverse latex as previously defined in compositions (F) and (G) include monosaccharides, such as glucan or polysaccharides consisting only of glucose homopolymers, glucomanoglucan, xyloglycan, galactomannan (the degree of substitution (DS) of the D-galactose unit on the main D-mannose chain thereof is 0 to 1, more specifically 1 to 0.25), such as galactomannan derived from cassia gum (DS = 1 / 5), locust bean gum (DS = 1 / 4), tara gum (DS = 1 / 3), guar gum (DS = 1 / 2) or fenugreek gum (DS = 1).

[0139] Examples of thickening and / or gelling agents that may be combined with the self-reversible inverse latex as previously defined in compositions (F) and (G) include polysaccharides composed of monosaccharide derivatives, such as sulfated galactan and more specifically carrageenan and agar, uronan and more specifically algin, alginate and pectin, heteropolymers of monosaccharides and uronic acids and more specifically xanthan gum, gellan gum, gum arabic exudate and karaya gum exudate, or glucoseaminoglycans.

[0140] Examples of thickening and / or gelling agents that can be combined with the self-reversible inverse latex as previously defined in compositions (F) and (G) include cellulose, cellulose derivatives such as methyl cellulose, ethyl cellulose or hydroxypropyl cellulose, silicates, starch, hydrophilic starch derivatives or polyurethanes.

[0141] Examples of stabilizers that may be combined with the self-reversible inverse latex as previously defined in compositions (F) and (G) include single-crystal waxes and, more specifically, wax, mineral salts such as sodium chloride or magnesium chloride, or silicone polymers such as polysiloxane polyalkyl polyether copolymers.

[0142] Examples of solvents that can be combined with the self-reversible inverse latex as previously defined in compositions (F) and (G) include water, organic solvents such as glycerol, diglycerol, glycerol oligomer, ethylene glycol, propylene glycol, butylene glycol, 1,3-propanediol, 1,2-propanediol, hexylene glycol, diethylene glycol, xylitol, erythritol, sorbitol, water-soluble alcohols such as ethanol, isopropanol or butanol, or a mixture of the organic solvent and water.

[0143] Examples of thermal water or mineral water that can be combined with the self-reversible inverse latex as previously defined in compositions (F) and (G) include thermal water or mineral water having a mineralization of 300 mg / I or more, particularly Number, Vittel number, Vichy basin number, Uriage number, La Roche-Posay number, La Bourboule number, Enghien-les-Bains number, Saint-Gervais-les-Bains number, -les-Bains number, Allevard-les-Bains number, Digne number, It includes the numbers of Neyrac-les-Bains, Lons-le-Saunier, Rochefort, Saint Christau, Les Fumades, and Tercis-les-Bains.

[0144] Examples of hydrophobic agents that can be combined with the self-reversible inverse latex as previously defined in compositions (F) and (G) include xylenesulfonate, cumenesulfonate, hexyl polyglucoside, 2-ethylhexyl polyglucoside, and n-heptyl polyglucoside.

[0145] Examples of emulsifying surfactants that can be combined with the self-reversible inverse latex as previously defined in compositions (F) and (G) include nonionic surfactants, anionic surfactants, or cationic surfactants.

[0146] Examples of emulsifying nonionic surfactants that can be combined with the self-reversible inverse latex as previously defined in compositions (F) and (G) include esters of fatty acids and sorbitol, e.g., products sold under the names Montane™ 40, Montane™ 60, Montane™ 70, Montane™ 80, and Montane™ 85; compositions comprising 5 to 150 moles of ethylene oxide ethoxylated stearic acid and glycerol stearate, e.g., compositions comprising 135 moles of ethylene oxide ethoxylated stearic acid and glycerol stearate, sold under the name Simulsol™ 165; mannitan esters; ethoxylated mannitan esters; sucrose esters; methyl glucoside esters; An alkyl polyglycoside comprising 14 to 36 carbon atoms and containing linear or branched and saturated or unsaturated aliphatic radicals, such as tetradecyl polyglucoside, hexyldecyl polyglucoside, octadecyl polyglucoside, hexyldecyl polyxylloside, octadecyl polyxylloside, eicosyl polyglucoside, dodecosyl polyglucoside, 2-octyldodecyl polyxylloside or 12-hydroxystearyl polyglucoside; Compositions of linear or branched and saturated or unsaturated fatty alcohols comprising 14 to 36 carbon atoms and alkyl polyglycosides as described above, for example, compositions sold under the names Montanov™ 68, Montanov™ 14, Montanov™ 82, Montanov™ 202, Montanov™ S, Montanov™ WO18, Montanov™ L, Fluidanov™ 20X and Easynov™ are included.

[0147] Examples of anionic surfactants that can be combined with the self-reversible inverse latex as previously defined in compositions (F) and (G) include glyceryl stearate citrate, cetearyl sulfate, soaps such as sodium stearate or triethanolammonium stearate, and chlorided N-acylamino acid derivatives, such as stearoyl glutamate.

[0148] Examples of cationic emulsifying surfactants that can be combined with the self-reversible inverse latex as previously defined in compositions (F) and (G) include amine oxides, quaternium-82 and surfactants described in International Patent Application Publication WO 96 / 00719, and those mainly comprising fatty chains having 16 or more carbon atoms.

[0149] Examples of opacifiers and / or pearlescent agents that may be combined with the self-reversible inverse latex as previously defined in compositions (F) and (G) include sodium palmitate, sodium stearate, sodium hydroxystearate, magnesium palmitate, magnesium stearate, magnesium hydroxystearate, ethylene glycol monostearate, ethylene glycol distearate, polyethylene glycol monostearate, polyethylene glycol distearate, or fatty alcohols comprising 12 to 22 carbon atoms.

[0150] Examples of texturing agents that can be combined with the self-reversible inverse latex as previously defined in compositions (F) and (G) include N-acylamino acid derivatives, such as lauroyl lysine sold under the name Aminohope™ LL, starch octenylsuccinate sold under the name Dryflo™, myristyl polyglucoside sold under the name Montanov™ 14, cellulose fibers, cotton fibers, chitosan fibers, talc, sericite, or mica.

[0151] Examples of deodorizers that may be combined with the self-reversible inverse latex as previously defined in compositions (F) and (G) include alkali metal silicates, zinc salts, e.g., zinc sulfate, zinc gluconate, zinc chloride, or zinc lactate; quaternary ammonium salts, e.g., cetyltrimethylammonium salt or cetylpyridinium salt; glycerol derivatives, e.g., glycerol caprate, glycerol caprylate, or polyglycerol caprate; 1,2-decanediol, 1,3-propanediol; salicylic acid; sodium bicarbonate; cyclodextrin; metallic zeolite; Triclosan™; Aluminum bromohydrate, aluminum chlorohydrate, aluminum chloride, aluminum sulfate, aluminum zirconium chlorohydrate, aluminum zirconium trichlorohydrate, aluminum zirconium tetrachlorohydrate, aluminum zirconium pentachlorohydrate, aluminum zirconium octachlorohydrate, aluminum sulfate, sodium aluminum lactate, complexes of aluminum chlorohydrate and glycol, such as complexes of aluminum chlorohydrate and propylene glycol, complexes of aluminum dichlorohydrate and propylene glycol, complexes of aluminum sesquichlorohydrate and propylene glycol, complexes of aluminum chlorohydrate and polyethylene glycol, complexes of aluminum dichlorohydrate and polyethylene glycol, or complexes of aluminum sesquichlorohydrate and polyethylene glycol.

[0152] Examples of oils that can be combined with the self-reversible inverse latex as previously defined in compositions (F) and (G) include mineral oils, such as liquid paraffin, liquid petroleum jelly, isoparaffin, or white mineral oil; animal-derived oils, such as squalene or squalane; Vegetable oils, e.g., phytosqualane, sweet almond oil, coconut kernel oil, castor oil, jojoba oil, olive oil, rapeseed oil, peanut oil, sunflower oil, malt oil, corn oil, soybean oil, cottonseed oil, alfalfa oil, poppy oil, pumpkin seed oil, evening primrose oil, millet oil, barley oil, rye oil, safflower oil, candlenut oil, passionflower oil, hazelnut oil, palm oil, shea butter, apricot kernel oil, beauty-leaf oil, sisymbrium oil, avocado oil, calendula oil, oils derived from flowers or vegetables, ethoxylated vegetable oils; Synthetic oils, e.g., fatty acid esters, e.g., butyl myristate, propyl myristate, isopropyl myristate, cetyl myristate, isopropyl palmitate, octyl palmitate, butyl stearate, hexadecyl stearate, isopropyl stearate, octyl stearate, isocetyl stearate, dodecyl oleate, hexyl laurate, propylene glycol dicaprylate, esters derived from lanoleic acid, e.g., isopropyl lanoleate or isocetyl lanoleate, fatty acid monoglycerides, diglycerides and triglycerides, e.g., glycerol triheptanoate, alkyl benzoates, hydrogenated oils, poly(α-olefins), polyolefins, e.g., poly(isobutene), synthetic isoalkanes, e.g., isohexadecane or isododecane, or perfluorinated oils;Silicone oils include, for example, dimethylpolysiloxane, methylphenylpolysiloxane, silicone modified by amine, silicone modified by fatty acid, silicone modified by alcohol, silicone modified by alcohol and fatty acid, silicone modified by polyether groups, epoxy-modified silicone, silicone modified by fluoro groups, cyclic silicone, and silicone modified by alkyl groups. In this patent application, the term "oil" refers to a compound and / or a mixture of compounds that has a liquid appearance at a temperature of 25°C and is water-insoluble.

[0153] Examples of waxes that may be combined with the self-reversible inverse latex as previously defined in compositions (F) and (G) include beeswax, carnauba wax, candelilla wax, ouricury wax, Japan wax, cork fiber wax, sugarcane wax, paraffin wax, lignite wax, microcrystalline wax, lanolin wax; and hemp wax, polyethylene wax, silicone wax, vegetable wax, fatty alcohols and fatty acids (solid at room temperature), or glycerides (solid at room temperature). In this patent application, the term “wax” refers to a compound and / or a mixture of compounds that have a solid appearance at a temperature of 45°C or higher and are water-insoluble.

[0154] Examples of active ingredients that may be combined with the self-reversible inverse latex as previously defined in compositions (F) and (G) above include vitamins and their derivatives, in particular their esters, such as retinol (vitamin A) and its ester (e.g., retinyl palmitate), ascorbic acid (vitamin C) and its ester, sugar derivatives of ascorbic acid (e.g., ascorbyl glucoside), tocopherol (vitamin E) and its ester (e.g., tocopheryl acetate), vitamin B3 or B10 (niacinamide and its derivatives); Compounds exhibiting whitening or depigmenting effects on the skin, e.g., ω-undecylenoyl phenylalanine sold under the name Sepiwhite™ MSH, Sepicalm™ VG, glycerol monoester and / or glycerol diester of ω-undecylenoyl phenylalanine, ω-undecylenoyl dipeptide, arbutin, kojic acid, hydroquinone; compounds exhibiting soothing effects, particularly Sepicalm™ S, allantoin, and bis-abolol; anti-inflammatory agents; compounds exhibiting moisturizing effects, e.g., urea, hydroxyurea, glycerol, polyglycerol, glycerol glucoside, diglycerol glucoside, polyglyceryl glucoside, xylityl glucoside; polyphenol-rich plant extracts, e.g., grape extract, pine extract, wine extract, or olive extract; Compounds exhibiting weight loss or lipolytic activity, e.g., caffeine or its derivatives, Adiposlim™, Adipoless™, fucoxanthin; N-acylated proteins; N-acylated peptides, e.g., Matrixyl™; N-acylated amino acids; partial hydrolysates of N-acylated proteins; amino acids; peptides; total hydrolysates of proteins; soybean extracts, e.g., Raffermine™; wheat extracts, e.g., Tensine™ or Gliadine™; plant extracts, e.g., tannin-rich plant extracts, isoflavone-rich plant extracts, or terpene-rich plant extracts; biliary or algal extracts; marine plant extracts; common marine organism extracts, e.g., coral; essential waxes; bacterial extracts;Ceramides; phospholipids; compounds exhibiting antimicrobial or cleansing action, e.g., Lipacide™ C8G, Lipacide™ UG, Sepicontrol™ A5; Octopirox™ or Sensiva™ SC50; compounds exhibiting invigorating or stimulating properties, e.g., Physiogenyl™, panthenol and its derivatives, e.g., Sepicap™ MP; anti-aging active ingredients, e.g., Sepilift™ DPHP, Lipacide™ PVB, Sepivinol™, Sepivital™, Manoliva™, Phyto-Age™, Timecode™; Survicode™; anti-photoaging active ingredients; active ingredients protecting the integrity of the epidermal-dermal junction; active ingredients increasing the synthesis of components of the extracellular matrix, e.g., collagen, elastin, or glycosaminoglycans; active ingredients acting favorably on chemical cell communication, e.g., cytokines; or active ingredients acting favorably on physical cell communication, e.g., integrins; Active ingredients that generate a "warm sensation" on the skin, such as skin microcirculation activators (e.g., nicotinic acid derivatives) or products that generate a "cold sensation" on the skin (e.g., menthol and derivatives); active ingredients that improve skin microcirculation, such as venotonics; drainage active ingredients; active ingredients for decongestant purposes, such as Ginkgo biloba, ivy, horse chestnut, bamboo, Ruscus, butcher's broom, Centella asiatica, fucus, rosemary, or willow extracts;Preparations that tan or brown the skin, e.g., dihydroxyacetone (DHA), erythrulose, mesotartaric aldehyde, glutaraldehyde, glyceraldehyde, alloxan, or ninhydrin; plant extracts, e.g., extracts of redwood of the genus Pterocarpus and the genus Baphia, such as Pterocarpus santalinus, Pterocarpus osun, Pterocarpus soyauxii, Pterocarpus erinaceus, Pterocarpus indicus, or Baphia nitida, e.g., as described in European patent application EP 0 971 683 Things; preparations known to facilitate and / or accelerate the tanning and / or browning of human skin and / or to color human skin, e.g., carotenoids (and more specifically β-carotene and γ-carotene), containing carotenoids, vitamin E and vitamin K, brand name Carrot Oil (INCI name: Daukus Carota) by Provital (; Duke carrot ), Helianthus Annous( Sunflower annualProducts sold as ) sunflower oil); products sold by Provital under the brand name "SunTan Accelerator™" containing tyrosine and / or its derivatives, e.g., tyrosine and riboflavin (vitamin B), which are known to be effective in accelerating tanning of human skin in combination with exposure to ultraviolet radiation; a complex of tyrosine and tyrosinase sold by Zymo Line under the brand name "Zymo Tan Complex"; and products containing acetyl tyrosine, sold by Mibelle under the brand name MelanoBronze™ (INCI name: Acetyl tyrosine, Monk's pepper extract (Vitex Agnus-Castus ( Vitex agnus- chasteProducts sold as )), products sold by Unipex under the brand name Unipertan VEG-24 / 242 / 2002 (INCI: Butylene glycol and acetyl tyrosine and hydrolyzed plant protein and adenosine triphosphate), products containing marrow seed extract (or loofah oil), products sold by Sederma under the brand name Try-Excell™ (INCI: Oleyl tyrosine and Luffa Cylindrica (seed) oil and oleic acid), products sold by Alban Muller under the brand name Actibronze™ (INCI: Hydrolyzed wheat protein and acetyl tyrosine and copper gluconate), products sold by Synerga under the brand name Tyrostan™ (INCI: Potassium caproyl tyrosine), products sold by Synerga under the brand name Tyrosinol (INCI: Sorbitan Products sold under the names Isostearate, Glyceryl Oleate, and Caproyl Tyrosine; products sold by Alban Muller under the brand name InstaBronze™ (INCI name: Dihydroxyacetone, Acetyl Tyrosine, and Copper Gluconate); and products sold by Exymol under the brand name Tyrosilane (INCI name: Methylsilanol and Acetyl Tyrosine);Peptides known to be effective in activating melanogenesis, e.g., the product sold by Infinitec Activos under the brand name Bronzing SF Peptide powder (INCI name: Dextran and Octapeptide-5); the product sold under the brand name Melitane (INCI name: Glycerin and Aqua and Dextran and Acetyl Hexapeptide-1), containing Acetyl Hexapeptide-1 known for its α-MSH agonist action; the product sold by Lipotec under the brand name Melatimes Solutions™ (INCI name: Butylene Glycol, Palmitoyl Tripeptide-40); sugars and sugar derivatives, e.g., the product sold by Provital under the brand name Tanositol™ (INCI name: Inositol); and Thalitan™ (or Phycosaccharide™), sold by CODIF International, containing marine-derived oligosaccharides (mannuronic acid and gluturonic acid chelated with magnesium and manganese ions). Products sold under AG (INCI name: Aqua and hydrolyzed algin (Laminaria digitata and magnesium sulfate and manganese sulfate), products sold by Alban Muller under the brand name Melactiva™ (INCI name: Maltodextrin, Mucuna Pruriens seed extract), known to be rich in flavonoid-rich compounds, e.g., lemon flavonoids (hesperidin type), and by Silab under the brand name "Biotanning" (INCI name: Hydrolyzed Citrus Aurantium dulcis; Orange sweetProducts sold as ) fruit extracts; Preparations intended for hair and / or body hair treatment, for example, preparations intended to protect the melanocytes of the hair follicle from cytotoxic agents that cause senescence and / or apoptosis of the melanocytes of the hair follicle, such as mimetics of DOPAchrome tautomerase activity selected from those described in the European patent application disclosed in European Patent EP 1 515 688 A2, synthetic molecules mimicking SOD, for example manganese complexes, antioxidant compounds, for example cyclodextrin derivatives, ascorbic acid, siliceous compounds derived from lysine pyrrolidone carboxylate or arginine pyrrolidone carboxylate, combinations of mono- and diesters of vitamin C and cinnamic acid, and more generally, those mentioned in the European patent application disclosed in European Patent EP 1 515 688 A2.

[0155] Examples of antioxidants that can be combined with the self-reversible inverse latex as previously defined in compositions (F) and (G) include EDTA and its salts, citric acid, tartaric acid, oxalic acid, BHA (butylated hydroxyanisole), BHT (butylated hydroxytoluene), tocopherol derivatives such as tocopheryl acetate, and mixtures of antioxidant compounds such as Dissolvine™ GL 47S (INCI name: tetrasodium glutamate diacetate) sold by AkzoNobel.

[0156] Examples of sunscreens that can be combined with the self-reversible inverse latex as previously defined in compositions (F) and (G) include all those set forth in the modified Cosmetics Directive 76 / 768 / EEC, Annex VII.

[0157] Among the organic sunscreens that can be combined with the self-reversible inverse latex as previously defined in compositions (F) and (G) above are a series of benzoic acid derivatives, e.g., para-aminobenzoic acid (PABA), particularly monoglyceryl esters of PABA, ethyl esters of N,N25-propoxy PABA, ethyl esters of N,N-diethoxy PABA, ethyl esters of N,N-dimethyl PABA, methyl esters of N,N-dimethyl PABA, and butyl esters of N,N-dimethyl PABA; a series of anthranilic acid derivatives, e.g., homomentyl-N-acetyl anthranilate; a series of salicylic acid derivatives, e.g., amyl salicylate, homomentyl salicylate, ethylhexyl salicylate, phenyl salicylate, benzyl salicylate, and p-isopropanolphenyl salicylate; A series of cinnamic acid derivatives, e.g., ethylhexyl cinnamate, ethyl-4-isopropyl cinnamate, methyl 2,5-diisopropyl cinnamate, p-methoxypropyl cinnamate, p-methoxyisopropyl cinnamate, p-methoxyisoamyl cinnamate, p-methoxyoctyl cinnamate (p-methoxy 2-ethylhexyl cinnamate), p-methoxy-2-ethoxyethyl cinnamate, p-methoxycyclohexyl cinnamate, ethyl-α-cyano-β-phenyl cinnamate, 2-ethylhexyl-α-cyano-β-phenyl cinnamate or glyceryl di-para-methoxymono-2-ethylhexanoyl cinnamate; a series of benzophenone derivatives, e.g., 2,4-dihydroxybenzophenone, 2,2'-dihydroxy-4-methoxybenzophenone, 2,2',4,4'-Tetrahydroxybenzophenone, 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxy-4'-methylbenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonate, 4-phenylbenzophenone, 2-ethylhexyl 4'-phenylbenzophenone-2-5-carboxylate, 2-hydroxy-4-n-octyoxybenzophenone, 4-hydroxy-3-carboxybenzophenone; 3-(4'-methylbenzylidene)-d,l-campphor, 3-(benzylidene)-d,l-campphor, campphor benzalkonium methosulfate; urocanic acid, ethyl urocanate;A series of sulfonic acid derivatives, e.g., 2-phenylbenzimidazole-5-sulfonic acid and salts thereof; A series of triazine derivatives, e.g., hydroxyphenyltriazine, ethylhexyloxyhydroxyphenyl)-4-methoxyphenyltriazine, 2,4,6-trianilino(p-carbo-2'-ethylhexyl-1'-oxy)-1,3,5-triazine, 4,4-((6-(((1,1-dimethylethyl)amino)carbonyl)phenyl)amino)-1,3,5-triazine-2,4-diyldiimino)bis(2-ethylhexyl)benzoate, 2-phenyl-5-methylbenzoxazole, 2,2'-hydroxy-5-methylphenylbenzotriazole, 2-(2'-hydroxy-5'-t-octylphenyl)benzotriazole, 2-(2'-hydroxy-5'-methylphenyl)benzotriazole; dibenzazine; There are dianisoylmethane, 4-methoxy-4''-t-butylbenzoylmethane; 5-(3,3-dimethyl-2-norbornylidene)-3-pentan-2-one; a series of diphenylacrylate derivatives, e.g., 2-ethylhexyl 2-cyano-3,3-diphenyl-2-propenoate, ethyl 2-cyano-3,3-diphenyl-2-propenoate; a series of polysiloxanes, e.g., benzylidene siloxane malonate.;

[0158] A mineral sunscreen, also known as a “mineral sunblock,” which can be combined with the self-reversible inverse latex as previously defined in compositions (F) and (G), comprises titanium oxide, zinc oxide, cerium oxide, zirconium oxide, yellow, red or black iron oxide, or chromium oxide. Such mineral sunblocks may be micronized or not micronized, may or may not undergo surface treatment, and may optionally be provided in the form of an aqueous or oily predispersion.

[0159] The present invention will now be explained in more detail by the following examples. Specific details for implementing the invention

[0160] Examples

[0161] 1.1 Preparation of an inverse latex (IL1) comprising a crosslinked copolymer of partially chlorided acrylic acid in the form of a sodium salt and a sodium salt of 2-methyl-[(1-oxo-2-propenyl)amino]-1-propanesulfonic acid, containing ethylenediaminedisuccinic acid in the form of a trisodium salt as a metal ion chelating agent.

[0162] While stirring, add the following to the beaker:

[0163] - 277 g of deionized water,

[0164] - Glacial acrylic acid 73.1 g,

[0165] - 2-methyl-[(1-oxo-2-propenyl)amino]-1-propanesulfonic acid 308 g,

[0166] - 141 g of 48 wt% aqueous sodium hydroxide solution,

[0167] - 0.62 g of a commercial 35 wt% solution of ethylenediaminedisuccinic acid in the form of a trisodium salt (sold under the brand name Natriquest™ E30),

[0168] - Methylenebis(acrylamide) 0.128 g,

[0169] - 0.1 g copper sulfate pentahydrate (i.e., an amount of 160 mol ppm relative to the sum of the moles of 2-methyl-[(1-oxo-2-propenyl)amino]-1-propanesulfonic acid and the moles of acrylic acid).

[0170] Adjust the pH of the aqueous phase to 5.4 and make the solution 682 g with deionized water.

[0171] Simultaneously manufacture the organic phase:

[0172] - Isohexadecane 220 g

[0173] - Montane 80 25 g,

[0174] - Azobis(isobutyronitrile) (AIBN) 0.2 g.

[0175] The aqueous phase prepared above is gradually added to the oil phase, and then dispersed using the Ultra-Turrax™ rotor-stator sold by IKA.

[0176] Afterward, the obtained emulsion is transferred to a jacketed reactor, and oxygen is removed by spraying nitrogen. A solution containing 0.42 wt% cumene hydroperoxide in isohexadecane is introduced, and the emulsion is continuously stirred for 5 minutes of homogenization at room temperature.

[0177] A 0.1% aqueous sodium metabisulfite solution in 25 g of water is introduced using a pump at a flow rate of 0.5 ml / min to initiate the polymerization reaction. The temperature of the medium is increased until a plateau is reached. Then, the reaction medium is heated at 85°C for 1 hour, and then the entire medium is cooled to about 35°C, and 50 g of polysorbate 80, sold under the brand name Montanox™ 80, is added.

[0178] The generated self-reversible inverse latex is evaluated by observing its appearance at 25°C, its viscosity at 25°C, the viscosity of an aqueous gel containing 2 mass% of the self-reversible inverse latex, and the viscosity of an aqueous gel containing 3 mass% in the presence of 0.1 mass% of sodium chloride.

[0179] This test is standardized (IL1).

[0180] The results obtained are provided in Table 1 below.

[0181] 1.2 Preparation of inverse latex (IL2) comprising a crosslinked copolymer of partially chlorinated acrylic acid and the sodium salt of 2-methyl-[(1-oxo-2-propenyl)amino]-1-propanesulfonic acid, containing sodium diethylenetriamine pentaacetate as a metal ion chelating agent.

[0182] Instead of the ethylenediaminedisuccinic acid solution in the form of a trisodium salt, 0.45 g of a solution containing 40 wt% sodium diethylenetriaminepentaacetate (sold under the brand name Versenex™ 80) is used to perform the same protocol as in the example described above.

[0183] This test is standardized (IL2).

[0184] 1.3 Preparation of an inverse latex (IL3) comprising a crosslinked copolymer of partially chlorinated acrylic acid and the sodium salt of 2-methyl-[(1-oxo-2-propenyl)amino]-1-propanesulfonic acid, containing N,N-diacetic glutamate tetrasodium salt (Dissolvine GLDA 47-S) as a metal ion chelating agent.

[0185] The same protocol as in Example 1.1 is performed using 2 g of a solution containing 47 wt% of N,N-diacetic glutamate tetrasodium salt (sold under the brand name Dissolvine™ GLDA 47-S) instead of a solution of ethylenediaminedisuccinic acid in the form of a trisodium salt.

[0186] This test is standardized (IL3).

[0187] 1.4 Preparation of inverse latex (IL4) comprising a crosslinked copolymer of partially chlorided acrylic acid and the sodium salt of 2-methyl-[(1-oxo-2-propenyl)amino]-1-propanesulfonic acid.

[0188] The same protocol as in Example 1.1 is performed without using a metal ion blocking agent.

[0189] This test is standardized (IL4).

[0190] 1.5 Preparation of an inverse latex (IL5) comprising a crosslinked copolymer of partially chlorinated acrylic acid and the sodium salt of 2-methyl-[(1-oxo-2-propenyl)amino]-1-propanesulfonic acid, containing ethylenediaminedisuccinic acid in the form of a trisodium salt as a metal ion chelating agent.

[0191] Perform the same protocol as in Example 1.1, but reduce the amount of metal ion chelating agent to 0.15 g of ethylenediaminedisuccinic acid in the form of a trisodium salt (sold under the brand name Natriquest™ E30).

[0192] This test is standardized (IL5).

[0193] 1.6 Preparation of an inverse latex (IL6) comprising a crosslinked copolymer of partially chlorinated acrylic acid and a sodium salt of 2-methyl-[(1-oxo-2-propenyl)amino]-1-propanesulfonic acid, containing ethylenediaminedisuccinic acid in the form of a trisodium salt as a metal ion chelating agent without adding CuSO4.

[0194] A copolymer is prepared according to the same protocol as in Example 1.1 without adding copper sulfate, and accordingly without adding Cu2+ salt.

[0195] This test is standardized (IL6).

[0196] [Table 1]

[0197]

[0198] Characteristics of the copolymers obtained in Examples 1.1, 1.2, 1.3, 1.4, 1.5, and 1.6.

[0199] (*): The amount of metal ion chelating agent is expressed in molar ppm and is calculated based on the molar sum of the two monomers (2-methyl-[(1-oxo-2-propenyl)amino]-1-propanesulfonic acid and acrylic acid).

[0200] Test (IL4) demonstrates the effect of the presence of a proven metal cation on the progress of the polymerization process: in the presence of copper cations (in this case, more than 160 mol ppm of Cu2+ ions) and in the absence of any metal ion chelating agent, no polymerization reaction occurs. In test (IL2), when sodium diethylenetriamine pentaacetate (sold under the brand name Versenex™ 80) is introduced, a polymerization reaction occurs and a polymer having thickening properties in water and brine solutions is obtained.

[0201] In contrast, when using ethylenediaminedisuccinic acid in the form of a trisodium salt (sold under the brand name Natriquest™ E30) in test (IL1) under the same stoichiometric conditions as test (IL2), a self-reversible inverse latex with polymerization kinetics similar to those observed for test (IL2) and equivalent viscosizing performance can be obtained. As can be seen in test (IL5), the amount of ethylenediaminedisuccinic acid in the form of a trisodium salt must be sufficiently high: if introduced at a lower dose (60 mol ppm), it is not possible to complex all the cations, which leads to the absence of polymerization initiation. Furthermore, test (IL6), in which copper cations are not added, shows that the above process occurs in the same way: ethylenediaminedisuccinic acid in the form of a trisodium salt does not affect the polymerization reaction.

[0202] Test (IL3) shows that N,N-diacetic glutamate tetrasodium salt (sold under the brand name Dissolvine™GLDA 47-S) has lower efficacy despite having a higher chelating capacity (85 mg Cu per 1 g of metal ion chelating agent [1]) than the chelating capacity of ethylenediaminedisuccinic acid in its trisodium salt form (18.4 mg Cu per 1 g of metal ion chelating agent [2]). Specifically, when added before polymerization under the same stoichiometric conditions, N,N-diacetic glutamate tetrasodium salt enables the initiation of the polymerization reaction, but the kinetics are slower than in tests (IL2) and (IL1): the reaction time is nearly twice as long. Similarly, the observed exothermicity is lower, suggesting that the conversion of the monomer is incomplete. Therefore, the process was not performed properly.

[0203] [1]: Nouryon’s “Product Data Sheet”, Dissolvine GL-47-S dated July 3, 2019

[0204] [2]: Technical sheet for Ineos’ Natriquest, “March 2008 issue”.

[0205] [3]: "Technical Data Sheet; Versenex™80", Dow, "Form No. 113-01342-0812 AMS", published August 2012.

[0206] II: Exemplary Cosmetic Formulations

[0207] In the following formulations, the percentage is expressed as a mass percentage per 100% of the mass of the formulation.

[0208] Example II-1: Care Cream

[0209] Cyclomethicone: 10%

[0210] Self-reversible inverse latex (IL6): 0.8%

[0211] Montanov™ 68: 2%

[0212] Stearyl alcohol: 1%

[0213] Stearic alcohol: 0.5%

[0214] Preservatives: 0.65%

[0215] Lee Sin: 0.025%

[0216] Xanthan Gum: 0.2%

[0217] Glycerol: 3%

[0218] Water: Appropriate amount for 100%

[0219] Example II-2: Antisun Milk

[0220] Formulation

[0221] A Montanov™ 68: 3.0%

[0222] Sesame oil: 5.0%

[0223] Parsol™ MCX: 5.0%

[0224] λ-Carrageenan: 0.10%

[0225] B Water: An appropriate amount for 100%

[0226] C Self-reversible Inverse Latex (IL6): 0.80%

[0227] D Flavoring: Appropriate amount

[0228] Preservatives: Appropriate amount

[0229] procedure

[0230] Emulsify B in A at 60°C, then add C at approximately 60°C, then add D at approximately 30°C, and adjust the pH if necessary.

[0231] Example II-3: Body milk

[0232] Montanov™ 202: 3.5%

[0233] Lanol™ 37T: 8.0%

[0234] Solagum™ L: 0.05%

[0235] Water: Appropriate amount for 100%

[0236] Benzophenone-3: 2.0%

[0237] Dimethicone 350 cPs: 0.05%

[0238] Self-reversible inverse latex (IL6): 2.5%

[0239] Preservatives: 0.2%

[0240] Fragrance: 0.4%

[0241] Example II-4: Makeup-removing emulsion containing sweet almond oil

[0242] Montanov™ 202: 5%

[0243] Sweet almond oil: 5%

[0244] Water: Appropriate amount for 100%

[0245] Self-reversible inverse latex (IL6): 0.3%

[0246] Glycerol: 5%

[0247] Preservatives: 0.2%

[0248] Fragrance: 0.3%

[0249] Example II-5: Moisturizing cream for oily skin

[0250] Montanov™ 68: 5%

[0251] Cetylstearyl octanoate: 8%

[0252] Octyl palmitate: 2%

[0253] Water: Appropriate amount for 100%

[0254] Self-reversible inverse latex (IL6): 2.6%

[0255] Micropearl™ M100: 3.0%

[0256] Mucopolysaccharides: 5%

[0257] Sepicide™ HB: 0.8%

[0258] Fragrance: 0.3%

[0259] Example II-6: Makeup-removing milk

[0260] Montanov™ 68: 3%

[0261] Primol™ 352: 8.0%

[0262] Sweet almond oil: 2%

[0263] Water: Appropriate amount for 100%

[0264] Self-reversible inverse latex (IL6): 0.8%

[0265] Preservatives: 0.2%

[0266] Example II-7: Antisun Milk

[0267] Montanov™ L: 3.5%

[0268] Lanol™ 37T: 10.0%

[0269] Parsol™ MCX: 5.0%

[0270] Eusolex™ 4360: 2.0%

[0271] Water: Appropriate amount for 100%

[0272] Self-reversible inverse latex (IL6): 1.8%

[0273] Preservatives: 0.2%

[0274] Fragrance: 0.4%

[0275] Example II-8: Sunless Tanning Emulsion

[0276] Lanol™ 99: 15%

[0277] Montanov™ 68: 3.0%

[0278] Parsol™ MCX: 3.0%

[0279] Water: Appropriate amount for 100%

[0280] Dihydroxyacetone: 5.0%

[0281] Monosodium phosphate: 0.2%

[0282] Self-reversible inverse latex (IL6): 2.5%

[0283] Fragrance: 0.3%

[0284] Sepicide™ HB: 0.8%

[0285] Sodium hydroxide: Appropriate amount for pH = 5

[0286] Example II-9: Care Cream

[0287] Cyclomethicone: 10%

[0288] Self-reversible inverse latex (IL6): 2.8%

[0289] Montanov™ 202: 4.5%

[0290] Preservatives: 0.65%

[0291] Lee Sin: 0.025%

[0292] Xanthan Gum: 0.2%

[0293] Glycerol: 3%

[0294] Water: Appropriate amount for 100%

[0295] Example II-10: Anti-sun cream

[0296] Simulsol™ 165: 3%

[0297] Montanov™ 68: 2%

[0298] C12-C15 Benzoate: 8%

[0299] Pecosil™ PS 100: 2%

[0300] Dimethicone: 2%

[0301] Cyclomethicone: 5%

[0302] Octyl para-methoxycinnamate: 6%

[0303] Benzophenone-3: 4%

[0304] Titanium oxide: 8%

[0305] Xanthan Gum: 0.2%

[0306] Butylene Glycol: 5%

[0307] Deionized water: An appropriate amount for 100%

[0308] Self-reversible inverse latex (IL6): 1.5%

[0309] Preservatives, fragrances: appropriate amounts

[0310] Example II-11: Anti-sun and self-tanning gel

[0311] Montanov™ 68: 3.0%

[0312] Glyceryl triheptanoate: 10.0%

[0313] Deepaline™ PVB: 1.05%

[0314] Self-reversible inverse latex (IL6): 2.2%

[0315] Water: Appropriate amount for 100%

[0316] Dihydroxyacetone: 5%

[0317] Fragrance: 0.1%

[0318] Sepicide™ HB: 0.3%

[0319] 30 Sepicide™ CI: 0.1%

[0320] Parsol™ MCX: 4.0%

Claims

Claim 1 A self-reversible inverse latex comprising an aqueous phase comprising: a) one or more first monomer units derived from 2-methyl-2-[(1-oxo-2-propenyl)amino]-1-propanesulfonic acid in a free acid form or in a partially or fully chlorinated form; one or more second monomer units derived from one or more monomers selected from the group consisting of acrylic acid, methacrylic acid, 2-carboxyethylacrylic acid, itaconic acid, maleic acid, and 3-methyl-3-[(1-oxo-2-propenyl)amino]butanoic acid (the carboxyl functional groups of said monomers are in a free acid form or in a partially chlorinated form or in a fully chlorinated form); and a cross-linked anionic polymer electrolyte (P) comprising one or more third monomer units derived from a polyethylene-based cross-linked monomer (AR); b) ethylenediaminedisuccinic acid in the form of a trisodium salt. Claim 2 A self-reversible inverse latex according to claim 1, characterized in that the aqueous phase comprises 0.01 mol% or more of ethylenediaminedisuccinic acid in the form of a trisodium salt. Claim 3 ◈Claim 3 was abandoned upon payment of the registration fee.◈ Self-reversible inverse latex according to Claim 1 or 2, wherein the polyethylene-based crosslinking monomer (AR) is selected from methylenebis(acrylamide), ethylene glycol dimethacrylate, diethylene glycol diacrylate, ethylene glycol diacrylate, diallylurea, trialylamine, trimethylolpropane triacrylate, diallyloxyacetic acid or sodium diallyloxyacetate, salts thereof, or mixtures thereof. Claim 4 ◈Claim 4 was abandoned upon payment of the registration fee.◈ Self-reversible inverse latex according to Claim 1 or 2, characterized in that the crosslinking monomer (AR) is methylenebis(acrylamide) or trialylamine. Claim 5 The self-reversible inverse latex according to claim 1 or 2, characterized in that the crosslinked anionic polymer electrolyte comprises the following per 100 mol%: - monomer units derived from 2-methyl-2-[(1-oxo-2-propenyl)amino]-1-propanesulfonic acid in a free acid form or in a partially or completely chlorinated form, in a ratio of 20 mol% to less than 90 mol%; - monomer units derived from one or more monomers selected from the group consisting of acrylic acid, methacrylic acid, 2-carboxyethylacrylic acid, itaconic acid, maleic acid, and 3-methyl-3-[(1-oxo-2-propenyl)amino]butanoic acid, in a ratio of 10 mol% to less than 80 mol% (the carboxyl functional groups of the monomers are in a free acid form or in a partially chlorinated form or in a completely chlorinated form); and - monomer units derived from one or more polyethylene-based crosslinked monomers (AR) in a ratio of greater than 0 mol% and less than or equal to 1 mol%. Claim 6 A method for manufacturing an inverse latex as defined in claim 1 or 2, comprising the following steps: a) preparing an aqueous phase as defined in claim 1 or 2; b) preparing an organic phase comprising one or more oils (O) and an oil-in-water type emulsion system (S1); c) mixing and emulsifying the aqueous phase and the organic phase prepared in steps a) and b) to form an emulsion; d) inactivating the emulsion with nitrogen; e) introducing a free radical initiator into the inactivated emulsion to initiate a polymerization reaction; and f) introducing an oil-in-water type emulsion system (S2) into the reaction medium produced from step e) at a temperature of 30°C to 60°C. Claim 7 ◈Claim 7 was abandoned upon payment of the registration fee.◈ A method according to Claim 6, characterized by comprising the step of adding a solution selected from sodium hydroxide solution, potassium hydroxide solution, ammonium hydroxide solution, monoethanolamine salt solution, and lysine salt solution to the aqueous phase prepared in step a) between step a) and step b). Claim 8 ◈Claim 8 was abandoned upon payment of the registration fee.◈ In claim 6, in step e), the radical initiator is a hydrogen sulfite (HSO3), such as a cumene hydroperoxide / sodium metabisulfite (Na2S2O5) pair or a cumene hydroperoxide / thionyl chloride (SOCl2) pair. - A method characterized by being a redox pair that generates ions. Claim 9 ◈Claim 9 was abandoned upon payment of the registration fee.◈ A method according to Claim 6, characterized by introducing a polymerization release agent into an inactivated emulsion in step e). Claim 10 ◈Claim 10 was abandoned upon payment of the registration fee.◈ A method according to claim 6, characterized in that, in step a), the pH of the aqueous phase is adjusted to 3.0 to 7.

0. Claim 11 ◈Claim 11 was abandoned upon payment of the registration fee.◈ A method according to claim 6, characterized in that the reaction medium derived from step e) is concentrated by distillation before performing step f). Claim 12 ◈Claim 12 was abandoned upon payment of the registration fee.◈ A method according to claim 6, characterized by spray-drying the reaction medium derived from step e) or f). Claim 13 ◈ Claim 13 was abandoned upon payment of the registration fee. ◈ A self-reversible inverse latex as defined in Claim 1 or 2, used as one or more of a thickener, an emulsifier, and a stabilizer for a topical cosmetic composition. Claim 14 A topical cosmetic composition (F) characterized by including, as a thickener, the inverse latex defined in claim 1 or 2 in an amount of 0.1 mass% to 10 mass% per 100% of total mass. Claim 15 ◈ Claim 15 was abandoned upon payment of registration fee. ◈ A self-reversible inverse latex as defined in claim 1 or 2, used as a thickener for a topical pharmaceutical composition (G).

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