Solid phantom for placing cultured cells and cultured cell irradiation system including the same

Abstract

The present invention relates to a solid phantom for fixing cultured cells and a radiation irradiation system including the same. By configuring the phantom block to be inserted and separated from the phantom body, the invention facilitates easy use and maintenance and enables precise radiation irradiation to cultured cells.

Description

Technology Field

[0001] The present invention relates to a solid phantom for fixing cultured cells and a radiation irradiation system including the same. By configuring the phantom block to be inserted and separated from the phantom body, the invention facilitates easy use and maintenance and enables precise radiation irradiation to cultured cells. Background Technology

[0002] Recently, advanced medical devices that treat diseases difficult to surgically treat, such as head and neck cancer, congenital arteriovenous malformations, pituitary tumors, meningiomas, schwannomas, metastatic brain tumors, and Parkinson's disease, using radiation have been devised and are widely used.

[0003] The aforementioned advanced radiation medical device utilizes a non-invasive treatment technique that removes lesions by selectively and intensively irradiating the affected area of ​​the human body with radiation, and applies a fractionated treatment method (hereinafter referred to as the first method) in which radiation is administered in multiple sessions at a dose that the normal tissue can withstand in order to minimize radiation exposure to the normal tissue surrounding the affected area.

[0004] In addition, advanced radiation medical devices apply a treatment technique (hereinafter referred to as the second method) that irradiates the affected area in multiple directions to reduce the exposure to normal tissues, while causing necrosis with 1-2 large doses of radiation.

[0005] Currently, the first method is used in radiation therapy, and the second method is used in radiosurgery.

[0006] Meanwhile, radiosurgery is preferred despite the high cost of the procedure because, compared to conventional surgical methods, it places a very low physical and mental burden on the patient, has fewer side effects such as complications, and allows for an immediate return to daily life.

[0007] When administering radiation using a radiation medical device, the radiation dose absorbed by the affected area is prescribed by comprehensively considering the patient's condition, the size and characteristics of the affected area, etc., and a radiation treatment plan (RTP) is established accordingly to administer an appropriate dose for treatment.

[0008] Although there are differences in the sensitivity of cancer cells to radiation therapy, if a technology is developed to predict individual sensitivity to radiation before therapy, it is possible to provide the most suitable radiation therapy for each individual by adjusting the radiation throughput to treat the cancer.

[0009] To determine the radiation sensitivity of cancer cells prior to radiation therapy, a method is needed to isolate cancer cells, irradiate them, and then accurately and rapidly analyze the degree of cell death. Prior art literature

[0010] Korean Published Patent Application No. 10-2007-0118394 (Published Dec. 17, 2007) The problem to be solved

[0011] The present invention was devised to solve the above-mentioned problems and aims to provide a solid phantom and a radiation irradiation system including the same, which allows for easy use and maintenance by configuring the phantom block to be inserted and separated from the phantom body, and enables precise radiation irradiation to cultured cells. means of solving the problem

[0012] A solid phantom for fixing cultured cells according to one example of the present invention comprises: a phantom body having an insertion groove formed therein; and a phantom block inserted and fixed in the insertion groove of the phantom body; wherein the phantom body and the phantom block are each made of a resin material, and the phantom block may include a first phantom block into which a detector is inserted and fixed, and a second phantom block into which a cell culture vessel is inserted and fixed.

[0013] The first phantom block and the second phantom block may have the same size and shape as each other.

[0014] It can be configured so that a horizontal beam is irradiated toward the front of the above-mentioned phantom body.

[0015] If the position where the detector is inserted and fixed in the first phantom block is called the reference position, the distance from the front of the second phantom block to the position where the cell culture vessel is inserted and fixed in the second phantom block can be configured to be the same as the distance from the front of the first phantom block to the reference position.

[0016] In the second phantom block above, the cell culture vessel can be positioned perpendicular to the horizontal beam.

[0017] One or more of the cell culture vessels may be accommodated in the second phantom block.

[0018] If the position in the second phantom block that matches the reference position in the first phantom block is called the matching point, then when one cell culture vessel is accommodated, that single cell culture vessel is placed on the matching point, and when two or more cell culture vessels are accommodated, those two or more cell culture vessels can be arranged dispersed around the matching point.

[0019] The second phantom block comprises a body, a container insertion groove formed in the body into which the cell culture container is inserted, and a cover that closes the container insertion groove, and may be structured such that the cell culture container is inserted into the container insertion groove of the body and closed by the cover.

[0020] The second phantom block comprises a body, a holder for fixing the cell culture vessel, and a holder insertion groove formed in the body into which the holder is inserted, wherein the cell culture vessel is fixed to the holder and the holder with the fixed cell culture vessel is inserted into the holder insertion groove of the body.

[0021] The cell culture vessel comprises at least one of a flask, a plate, and a tube, and the second phantom block is composed of multiple units, each of which may be configured to accommodate at least one of the flask, plate, and tube.

[0022] In the second phantom block, the flask, plate, and tube can each be positioned perpendicular to the horizontal beam.

[0023] The first phantom block comprises a body and a detector insertion groove formed in the body into which the detector is inserted, wherein the detector insertion groove is formed with an open top and can be configured so that the detector is inserted and removed through the open top of the detector insertion groove.

[0024] The insertion groove of the phantom body is formed with an open top, and the phantom block can be configured to be inserted and separated through the open top of the insertion groove.

[0025] The above phantom block may be provided with a handle to grip the phantom block.

[0026] The phantom block is slidably coupled to the insertion groove of the phantom body, and an air venting slot may be formed on at least one side of the inner wall surface of the insertion groove and the outer wall surface of the phantom block so that air can be discharged when the phantom block is slidably coupled to the insertion groove.

[0027] The corners of the lower surface of the above phantom block can be formed to be rounded.

[0028] The insertion groove of the phantom body may be formed in the central part of the phantom body based on the front-rear direction of the phantom body.

[0029] It further includes a dummy plate made of resin material; wherein one or more dummy plates are arranged in the direction in which radiation is irradiated, so as to be able to adjust the amount of radiation delivered to the insertion groove of the phantom body.

[0030] A culture cell irradiation system according to one example of the present invention may include the solid phantom for fixing culture cells described above; and a radiation irradiation device.

[0031] The system may be configured to insert the first phantom block into the phantom body and measure the absorbed dose reaching the detector when the radiation irradiation device irradiates radiation at a first energy level using the detector, remove the first phantom block from the phantom body and insert the second phantom block at the same location, and the radiation irradiation device irradiates cultured cells contained in the cell culture vessel of the second phantom block with radiation at the same level as the first energy level, and calculate the absorbed dose reaching the cultured cells based on the absorbed dose measured by the detector. Effects of the invention

[0032] The present invention is configured to allow the insertion and separation of a phantom block into a phantom body, thereby facilitating use and maintenance and enabling precise irradiation of cultured cells. Brief explanation of the drawing

[0033] FIG. 1 is a perspective view of a solid phantom according to an example of the present invention. Figure 2 is an exploded perspective view of the solid phantom of Figure 1. FIG. 3 is a perspective view of a phantom block according to an example of the present invention. Figure 4 is a drawing showing the first phantom block. Figure 5 is a drawing showing the second phantom block. Figure 6 is a side schematic diagram of Figure 3. FIG. 7 is a drawing showing a cell culture vessel according to an example of the present invention. FIG. 8 is a drawing showing a second phantom block according to an example of the present invention. FIG. 9 is an exploded perspective view of the second phantom block of the first type. FIG. 10 is an exploded perspective view of a second phantom block of the second type. FIG. 11 is an exploded perspective view of the second phantom block of the third type. FIG. 12 is a perspective view of a solid phantom according to an additional example of the present invention. FIG. 13 is a configuration diagram of a culture cell irradiation system according to an example of the present invention. Specific details for implementing the invention

[0034] Hereinafter, the present invention will be described with reference to the attached drawings.

[0035] FIG. 1 is a perspective view of a solid phantom according to an example of the present invention, and FIG. 2 is an exploded perspective view of the solid phantom of FIG. 1. The solid phantom (10) of the present invention is a solid phantom for fixing cultured cells, and includes a phantom body (100) as illustrated and a phantom block (200) assembled to the phantom body (100).

[0036] The phantom body (100) and the phantom block (200) each correspond to a solid phantom composed of a resin material. For example, the phantom body (100) and the phantom block (200) may be composed of at least one of acrylic, PMMA (polymethyl methacrylate), and PC (polycarbonate). The phantom body (100) and the phantom block (200) may be composed of the same material, which may provide manufacturing advantages.

[0037] The phantom body (100) is configured in a roughly cube shape, and an insertion groove (110) is formed in the phantom body (100). The insertion groove (110) of the phantom body is configured in a roughly rectangular shape that is wide in the left-right direction.

[0038] The phantom block (200) is configured with a size and shape corresponding to the insertion groove (110) of the phantom body and is inserted into and fixed in the insertion groove (110) of the phantom body.

[0039] The present invention may be configured for radiation horizontal beam irradiation. For example, a radiation irradiation device may be installed in front of a solid phantom (10) to irradiate a radiation horizontal beam (proton beam) toward the solid phantom (10), and accordingly, the horizontal beam may be irradiated toward the front of the phantom body (100), pass through the phantom block (200), and be emitted toward the rear of the phantom body (100). Considering the direction of radiation irradiation, the phantom block (200) may be configured with a wide structure in the left-right direction as described above.

[0040] FIG. 3 is a perspective view of a phantom block according to an example of the present invention, FIG. 4 is a drawing showing a first phantom block, and FIG. 5 is a drawing showing a second phantom block. The phantom block (200) of the present invention can be classified into a first phantom block (201) into which a detector (20) is inserted and fixed, and a second phantom block (202) into which a cell culture vessel (30) is inserted and fixed. That is, the present invention includes at least two phantom blocks (200).

[0041] The detector (20) is a known radiation dose measuring device that receives radiation from the outside and generates an electrical signal proportional to it, and is inserted and fixed in the first phantom block (201). The cell culture vessel (30) is a known culture vessel that accommodates cultured cells and is inserted and fixed in the second phantom block (202). The first phantom block (201) and the second phantom block (202) have the same size and shape as each other, and each is inserted into the insertion groove (110) of the phantom body.

[0042] The operating principle of the present invention is as follows. First, the present invention aims to irradiate cultured cells with precise radiation, that is, to accurately determine the amount of radiation irradiated to the cultured cells.

[0043] To this end, the present invention fixes a radiation irradiation device and a phantom body (100) at predetermined positions, inserts a first phantom block (201) into an insertion groove (110) of the phantom body, and measures the absorbed dose at the fixed position of the detector (20) using a detector (20) that is inserted and fixed in the first phantom block (201). Then, after removing the first phantom block (201) from the phantom body (100), a second phantom block (202) is inserted into the phantom body (100). At this time, since the phantom body (100) is fixed at a predetermined position, the fixed position of the second phantom block (202) is the same as the fixed position of the first phantom block (201), and accordingly, the radiation dose delivered to the second phantom block (202) can be estimated from the previously measured absorbed dose. Based on this, the amount of radiation irradiated to the cultured cells contained in the cell culture vessel (30) of the second phantom block (202) can be calculated based on the absorbed dose measured in advance, thereby making it possible to accurately determine the amount of radiation irradiated to the cultured cells.

[0044] Thus, according to the present invention, the dose applied to cultured cells can be measured easily, simply, and precisely, and accordingly, damage or changes to cultured cells due to the dose can be accurately analyzed.

[0045] Furthermore, since cultured cells are generally filled with liquid media or phosphate buffer solution, it is difficult to irradiate them with a horizontal beam. A horizontal beam irradiation setup has advantages over a vertical beam irradiation setup in terms of the installation and management of the irradiation device or phantom, as well as facility stability. The present invention provides a structure suitable for a horizontal beam irradiation setup for cultured cells, thereby providing the advantage of enabling simple and rapid irradiation of cultured cells. Below, we will examine a specific structure of the present invention that can implement this.

[0046] First, the position of the detector (20) and the position of the cell culture vessel (30) are configured to be the same. More specifically, if the position where the detector (20) is inserted and fixed in the first phantom block (201) is called the reference position (RP), the distance from the front of the second phantom block (202) to the position where the cell culture vessel (30) is inserted and fixed in the second phantom block (202) can be configured to be the same as the distance from the front of the first phantom block (201) to the reference position (RP).

[0047] FIG. 6 is a side schematic view of FIG. 3, and as shown, when the first phantom block (201) is viewed from the side, the distance (D_1) from the front of the first phantom block (201) to the detector (20) and when the second phantom block (202) is viewed from the side, the distance (D_2) from the front of the second phantom block (202) to the cell culture vessel (30) can be configured to be the same. This matches the reference depth for radiation of the cultured cells with the reference depth for radiation of the detector (20), and accordingly, can reduce the error between the dose processed by the cultured cells and the absorbed dose of the detector.

[0048] FIG. 7 is a drawing showing a cell culture vessel according to an example of the present invention, and FIG. 8 is a drawing showing a second phantom block according to an example of the present invention. As illustrated, the cell culture vessel (30) can be configured in various types, and based thereon, the second phantom block (202) can also be configured in various forms.

[0049] More specifically, the cell culture vessel (30) includes at least one of a flask (31), a plate (32), and a tube (33), and the second phantom block (202) may be configured in multiple types so that each can accommodate at least one of the flask (31), the plate (32), and the tube (33).

[0050] The flask (31) is composed of a column-shaped body that is wide from side to side and has a constant front-to-back width, and may be provided with a cap that closes the open top of the body, and may contain culture cells. The plate (32) may be composed of a cylindrical shape and may be structured such that a cover closes the open top of the body, and may contain culture cells between the body and the cover. The tube (33) is formed in the shape of a long pipe and may be provided with an open top or a separate cap that closes the open top, and may contain culture cells in the hollow space inside. The culture cells may be filled to the full internal space of the cell culture vessel.

[0051] At the same time or separately, one second phantom block (202) may be configured to accommodate one or more cell culture vessels (30). Depending on the combination of the type and number of such cell culture vessels (30), various forms of the second phantom block (202) may be produced. When multiple cell culture vessels (30) are accommodated in one second phantom block (202), it may be more preferable to configure the multiple cell culture vessels (30) to be of the same type and size to ensure uniform treatment of the dose for each cultured cell contained in each cell culture vessel (30).

[0052] At this time, in order to make the dose applied to the cultured cells uniform and match the pre-measured absorbed dose, the present invention may install the cell culture vessel (30) at a position corresponding to the reference position (RP).

[0053] More specifically, referring again to FIG. 8, if the position in the second phantom block (202) that matches the reference position (RP) in the first phantom block (201) is called the matching point (MP), then when one cell culture vessel (30) is housed, that single cell culture vessel (30) is placed on the matching point (MP), and when two or more cell culture vessels (30) are housed, those two or more cell culture vessels (30) can be configured to be dispersed around the matching point (MP). Through this, precise and rapid radiation irradiation can be performed on a large number of cultured cells.

[0054] FIG. 9 is an exploded perspective view of a second phantom block of the first type. As illustrated, the second phantom block (202) may include a body (212), a container insertion groove (222) formed in the body (212) into which a cell culture container (30) is inserted, and a cover (232) that closes the container insertion groove (222). The structure may be such that a cell culture container (30) is inserted into the container insertion groove (222) of the body and closed by the cover (232). The body (212) and the cover (232) may be formed with the same size and may be joined and fixed to each other using separate fixing means. The cell culture container (30) housed in the second phantom block (202) of the present type may be a flask (31). As illustrated, the flask (31) may have a wide portion arranged in the vertical direction and be positioned perpendicular to a horizontal beam.

[0055] FIG. 10 is an exploded perspective view of a second type of second phantom block. As illustrated, the second phantom block (202) may include a body (212), a container insertion groove (222) formed in the body into which a cell culture container (30) is inserted, and a cover (232) that closes the container insertion groove (222). The structure may be such that the cell culture container (30) is inserted into the container insertion groove (222) of the body and closed by the cover (232). The cover (232) may be configured to be smaller than the body in consideration of the placement of the cell culture container (30), and a groove into which the cover (232) is fitted may be formed in the body (212) so that the cover is fitted and fixed to the body. The cell culture container (30) housed in the second type of phantom block (202) may be a plate (32), and as illustrated, the plate (32) may be positioned upright and positioned perpendicular to a horizontal beam.

[0056] FIG. 11 is an exploded perspective view of a second phantom block of a third type. As illustrated, the second phantom block (202) may include a body (212), a holder (252) for fixing a cell culture vessel (30), and a holder insertion groove (242) formed in the body into which the holder (252) is inserted. The structure may be such that the cell culture vessel (30) is fixed to the holder (252), and the holder (252) to which the cell culture vessel (30) is fixed is inserted into the holder insertion groove (242) of the body. The holder insertion groove (242) may be formed to penetrate the body and have both sides open, or may be formed to have only one side open and the other side closed, and the holder (252) may be fitted into the holder insertion groove (242). The cell culture vessel (30) housed in the second phantom block (202) of this type may be a tube (33), and as illustrated, the tube (33) may have an elongated portion arranged in the vertical direction and be positioned perpendicular to the horizontal beam.

[0057] Meanwhile, referring again to FIG. 4, the first phantom block (201) includes a body (211) and a detector insertion groove (110) formed in the body (211) into which a detector (20) is inserted. The detector insertion groove (221) is formed with an open top, and the detector (20) can be configured to be inserted and removed through the open top of the detector insertion groove (221). Here, the detector insertion groove (221) may have a stepped structure formed in the middle, and an arm (21) supporting the detector (20) may be configured to correspond thereto to help to accurately position the detector (20) at a reference position (RP).

[0058] Referring again to FIGS. 2 to 5, the insertion groove (110) of the phantom body is formed with an open top, and the phantom block (200) can be configured to be inserted and separated through the open top of the insertion groove (110).

[0059] Additionally, the phantom block (200) may be provided with a handle (290) to allow the phantom block (200) to be grasped. The handle (290) may be installed on the upper part of the phantom block (200). This allows the user to easily grasp the phantom block (200) and easily insert and remove it from the upper part of the phantom body (100).

[0060] Furthermore, the phantom block (200) can be slidably coupled to the insertion groove (110) of the phantom body. That is, the phantom block (200) can be formed to be substantially the same size as the insertion groove (110) of the phantom body and configured to be in close contact with the inner wall surface of the insertion groove (110) of the phantom body, which can prevent errors in the dose caused by the gap formed between the phantom body (100) and the phantom block (200).

[0061] At this time, an air venting slot may be formed on at least one side of the inner wall surface of the insertion groove (110) of the phantom body and the outer wall surface of the phantom block (200) so that air can be discharged when the phantom block (200) is slidably coupled to the insertion groove (110). The air venting slot (280) may be formed on at least one side of the phantom block (200), for example as shown in FIG. 4, and may be configured in a shape with an extended upper and lower end. By being configured in this way, inserting the phantom block (200) into the phantom body (100) and separating it from the phantom body (100) can be performed more easily. In addition, by forming the corners of the lower surface of the phantom block (200) in a rounded shape, the phantom block (200) can be inserted more easily into the insertion groove (110) of the phantom body.

[0062] Referring again to FIGS. 1 and 2, the phantom block (200) is positioned in the center of the front-rear direction of the phantom body (100). More specifically, the insertion groove (110) of the phantom body is formed in the central part of the phantom body (100) based on the front-rear direction of the phantom body (100), and accordingly, the front part of the phantom body (100) can be positioned in front of the insertion groove (110), and the rear part of the phantom body (100) can be positioned behind the insertion groove (110).

[0063] This allows for the consideration of the effect of back scattering, which occurs when radiation directed toward the front of the phantom body (100) passes through the insertion groove (110) and scatters at the rear of the phantom body (100), thereby providing the advantage of being able to measure the dose at the reference position (RP) of the insertion groove (110) more precisely.

[0064] FIG. 12 is a perspective view of a solid phantom according to an additional example of the present invention, and as illustrated, the solid phantom (10) of the present invention may further include a dummy plate (190). The dummy plate (190) is made of a resin material and may be made of the same material as the resin material of the phantom body (100).

[0065] One or more of these dummy plates (190) are mounted in the direction in which radiation is irradiated, and accordingly, the amount of radiation delivered to the insertion groove (110) of the phantom body can be adjusted.

[0066] For example, as illustrated, one or more dummy plates (190) may be mounted in front of the phantom body (100) to adjust the reference depth to the radiation insertion groove (110). The dummy plates (190) may be composed of multiple plates, each having a thickness that may be the same or different from one another, and may be appropriately selected and positioned in close contact with the phantom body (100) by considering the energy magnitude of the radiation irradiated onto the phantom body (100).

[0067] Additionally, although not shown, a dummy plate (190) may also be mounted at the rear of the phantom body (100), and this can be appropriately selected considering the energy level of the radiation, or the actual radiation target or environment. When the dummy plate (190) is mounted at the rear of the phantom body (100), the effect of the backscattering of the radiation described above can be considered more precisely.

[0068] These dummy plates (190) can be securely fixed to the phantom body (100) through separate joining means, such as taping or bolting.

[0069] FIG. 13 is a configuration diagram of a culture cell irradiation system according to an example of the present invention. The irradiation system (1000) of the present invention may include the solid phantom (10) and the irradiation device (90) described above, and as illustrated, the solid phantom (10) and the irradiation device (90) may be set up as a horizontal beam. The irradiation device (90) may correspond to a linear accelerator, for example, as a therapeutic high-energy irradiator used in a hospital.

[0070] The operation method of the present system (1000) is as follows. First, a first phantom block (201) is inserted into the phantom body (100), and the absorbed dose reaching the detector (20) is measured using a detector (20) when the radiation irradiation device (90) irradiates radiation at a first energy level. Subsequently, the first phantom block (201) is removed from the phantom body (100), and the second phantom block (202) is inserted in the same location. Then, the radiation irradiation device (90) irradiates radiation of the same level as the first energy level to the cultured cells contained in the cell culture vessel (30) of the second phantom block (202).

[0071] At this time, the absorbed dose reaching the cultured cells can be calculated based on the absorbed dose measured by the detector (20). For example, the absorbed dose reaching the cultured cells can be used as is or partially corrected from the absorbed dose measured by the detector (20).

[0072] As described above, the present invention proposes a specific structure and operating or design principle of a solid phantom for fixing cultured cells, and a cultured cell irradiation system applying said solid phantom, thereby providing the advantage of being easy to use and maintain while enabling precise irradiation of cultured cells.

[0073] Although embodiments of the present invention have been described above with reference to the attached drawings, those skilled in the art will understand that the present invention may be implemented in other specific forms without changing its technical concept or essential features. Therefore, the embodiments described above should be understood as illustrative in all respects and not restrictive. Explanation of the symbols

[0074] 10: Solid Phantom 100: Phantom main body 110: Insertion slot 200: Phantom Block 201: The First Phantom Block 202: The Second Phantom Block 290: Handle 20: Detector 30: Cell culture vessel RP: Reference Position MP: Matching Point 1000: System 90: Radiation irradiation device

Claims

Claim 1 A phantom body with an insertion groove formed therein; The apparatus comprises: a phantom block inserted and fixed into an insertion groove of the phantom body; wherein the phantom body and the phantom block are each made of a resin material; wherein the phantom block comprises a first phantom block into which a detector is inserted and fixed, and a second phantom block into which a cell culture vessel is inserted and fixed, and is configured such that a horizontal beam is irradiated toward the front of the phantom body; wherein if the position where the detector is inserted and fixed in the first phantom block is defined as the reference position, the distance from the front of the second phantom block to the position where the cell culture vessel is inserted and fixed in the second phantom block is configured to be the same as the distance from the front of the first phantom block to the reference position; wherein the first phantom block comprises a body and a detector insertion groove formed in the body into which the detector is inserted, the detector insertion groove is formed with an open top, a stepped structure is formed in the middle of the detector insertion groove, and an arm supporting the detector is configured to correspond to the stepped structure to position the detector at the reference position; and A solid phantom for fixing cultured cells, configured such that the detector is inserted and separated through the open upper portion of the detector insertion groove. Claim 2 A solid phantom for fixing cultured cells, wherein the first phantom block and the second phantom block have the same size and shape as each other. Claim 3 delete Claim 4 delete Claim 5 A solid phantom for fixing cultured cells, wherein in the second phantom block, the cell culture vessel is positioned perpendicular to the horizontal beam. Claim 6 A solid phantom for fixing cultured cells according to claim 1, wherein the second phantom block accommodates one or more of the cell culture vessels. Claim 7 A solid phantom for fixing cultured cells according to claim 6, wherein a position in the second phantom block that matches the reference position in the first phantom block is called a matching point, and when one cell culture vessel is accommodated, the one cell culture vessel is placed on the matching point, and when two or more cell culture vessels are accommodated, the two or more cell culture vessels are each arranged dispersed around the matching point. Claim 8 A solid phantom for fixing cultured cells according to claim 1, wherein the second phantom block comprises a body, a container insertion groove formed in the body into which the cell culture container is inserted, and a cover that closes the container insertion groove, and is structured such that the cell culture container is inserted into the container insertion groove of the body and is closed by the cover. Claim 9 A solid phantom for fixing cultured cells according to claim 1, wherein the second phantom block comprises a body, a holder for fixing the cell culture vessel, and a holder insertion groove formed in the body into which the holder is inserted, and wherein the cell culture vessel is fixed to the holder and the holder with the fixed cell culture vessel is inserted into the holder insertion groove of the body. Claim 10 A solid phantom for fixing cultured cells according to claim 1, wherein the cell culture vessel comprises at least one of a flask, a plate, and a tube, and the second phantom block is composed of a plurality of blocks, each configured to accommodate at least one of the flask, a plate, and a tube. Claim 11 In item 10, the flask, plate, and tube in the second phantom block are each positioned perpendicular to the horizontal beam, forming a solid phantom for fixing cultured cells. Claim 12 delete Claim 13 A solid phantom for fixing cultured cells according to claim 1, wherein the insertion groove of the phantom body is formed with an open top, and the phantom block is configured to be inserted and separated through the open top of the insertion groove. Claim 14 A solid phantom for fixing cultured cells according to claim 13, wherein the phantom block is provided with a handle to grip the phantom block. Claim 15 A solid phantom for fixing cultured cells according to claim 13, wherein the phantom block is slidably coupled to the insertion groove of the phantom body, and at least one of the inner wall surface of the insertion groove and the outer wall surface of the phantom block has an air venting slot formed therein so that air can be discharged when the phantom block is slidably coupled to the insertion groove. Claim 16 A solid phantom for fixing cultured cells according to claim 15, wherein the corners of the lower surface of the phantom block are formed to be rounded. Claim 17 A solid phantom for fixing cultured cells according to claim 1, wherein the insertion groove of the phantom body is formed in the central part of the phantom body based on the front-rear direction of the phantom body. Claim 18 A solid phantom for fixing cultured cells according to claim 1, further comprising a dummy plate made of a resin material, wherein one or more dummy plates are arranged in the direction in which radiation is irradiated, and the amount of radiation delivered to the insertion groove of the phantom body can be adjusted. Claim 19 A culture cell irradiation system comprising: a solid phantom for fixing culture cells according to claim 1; and a radiation irradiation device. Claim 20 A culture cell radiation irradiation system according to claim 19, wherein the first phantom block is inserted into the phantom body and the absorbed dose reaching the detector is measured using the detector when the radiation irradiation device irradiates radiation at a magnitude of the first energy, the first phantom block is removed from the phantom body and the second phantom block is inserted at the same location, the radiation irradiation device irradiates culture cells contained in the cell culture vessel of the second phantom block with radiation of the same magnitude as the first energy, and the absorbed dose reaching the culture cells is calculated based on the absorbed dose measured by the detector.

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