Hybrid implant manufacturing system capable of hybrid surface processing and drug-release-controlled coating, and hybrid implant manufactured thereby

Abstract

The present invention relates to a hybrid implant manufacturing system capable of hybrid surface processing and drug release control coating, and to the hybrid implant itself. More specifically, the invention relates to a hybrid implant manufacturing system capable of hybrid surface processing and drug release control coating that can significantly increase human safety by not using an acid etching process on the implant surface, and to the hybrid implant itself, which forms nano patterns of different roughness levels in different parts of the implant and coats different drugs in different parts to allow for differential drug release, thereby enabling effective anti-inflammatory and bone formation effects during and after the initial implantation of the implant.

Description

Technology Field

[0001] The present invention relates to a hybrid implant manufacturing system capable of hybrid surface processing and drug release control coating, and to the hybrid implant itself. More specifically, the invention relates to a hybrid implant manufacturing system capable of hybrid surface processing and drug release control coating that can significantly increase human safety by not using an acid etching process on the implant surface, and to the hybrid implant itself, which forms nano patterns of different roughness levels in different parts of the implant and coats different drugs in different parts to allow for differential drug release, thereby enabling effective anti-inflammatory and bone formation effects during and after the initial implantation of the implant. Background Technology

[0002] An implant is a dental treatment method performed after tooth extraction, which is the last resort for treating cavities or gum disease.

[0003] Generally, implants are treated by implanting an implant fixture, which is manufactured in the form of a screw, into the jawbone, attaching an abutment to it, and then covering the abutment with a crown, which is an artificial tooth.

[0004] Unlike conventional bridge fabrication methods, it is advantageous that the function and aesthetics of the teeth can be restored without damaging adjacent healthy teeth.

[0005] In particular, if many molars are missing, partial dentures must be worn; however, using implants eliminates the need for partial dentures. Furthermore, while the gums and jawbone in the areas where teeth are missing gradually absorb and shrink over time, implant surgery can prevent this.

[0006] Meanwhile, the most important aspect of implant treatment is that the implant fuses with the jawbone after being implanted, becoming one with it. If proper osseointegration of the implant does not occur, the implant may become loose in the jawbone, causing inflammation and making it impossible to recover chewing power. In severe cases, side effects such as the implant falling out may occur.

[0007] Conventionally, to improve the osseointegration of implants, the surface of the implant was treated through physicochemical methods such as SLA (sandblasted, large-grit, acid-etched), RBM (Resorbable Blast Media), anodizing, and etching. These surface treatment methods include sandblasting, which forms an arbitrary pattern by spraying multiple beads at high speed, and cleaning and controlling the average surface roughness (Ra).

[0008] Meanwhile, all of these surface treatment methods involve an acid-washing process, which requires a washing process to remove residual acid from the surface. However, if residual acid remains on the surface due to issues such as operator negligence or improper concentration control of the washing solution, it can cause the surrounding bone to erode or lead to inflammatory reactions after implant placement, potentially resulting in implant failure.

[0009] Furthermore, conventional physicochemical surface treatments result in the arbitrary formation of porosity and roughness on the implant surface, making it difficult to form the same pattern even under identical conditions; this limits the improvement of osseofusion. Prior art literature

[65535] 1. Korean Registered Patent No. 10-2921957, Surface treatment method for titanium implants 2. Korean Registered Patent No. 10-2908269, Hydrophilic surface treatment method for implant fixtures and implants manufactured thereby 3. Korean Registered Patent No. 10-2853482, Method for creating surface-treated implant structures using electron beams and implant structures manufactured using said method The problem to be solved

[0010] The present invention has been devised to solve the aforementioned problems, and the objective of the present invention is to provide a hybrid implant manufacturing system capable of forming roughness on the surface of an implant substrate without a chemical corrosion process or an acid washing process.

[0011] In addition, another objective of the present invention is to provide a hybrid implant manufacturing system capable of reducing the occurrence of inflammation and enhancing bone formation effects by forming different roughness levels in different zones of the implant substrate and applying a coating that fills the roughness pattern with drugs for the periodontium and alveolar bone.

[0012] In addition, another objective of the present invention is to provide a hybrid implant manufacturing system capable of reducing the occurrence of inflammation and maximizing the effect of bone formation by physically controlling the release rates of a drug for treating inflammation and a drug for bone formation. means of solving the problem

[0013] To achieve the above objective, the present invention provides a hybrid implant manufacturing system comprising: a brush unit that forms roughness by physically frictioning the surface of an implant substrate; a laser unit that forms a nano pattern by irradiating a laser beam onto the surface of the implant substrate after the roughness is formed by the brush unit; a controller that controls the output of the laser unit; and a coating device that coats a coating solution containing a biodegradable polymer and an anti-inflammatory agent or a bone formation inducer onto the nano pattern formed on the surface of the implant substrate; wherein the implant substrate rotates around a longitudinal axis or the brush unit rotates around a longitudinal axis and the brush end of the brush unit frictionally forms roughness on the surface of the implant substrate, and the brush unit or the laser unit imparts different roughnesses to different regions of the implant substrate.

[0014] In a preferred embodiment, the brushes of the brush unit have different intensities at different heights along the longitudinal axis, so that the laser unit imparts different roughness to different regions of the implant substrate.

[0015] The present invention provides a hybrid implant manufacturing system characterized in that the brushes of the brush unit have different intensities at different heights along the vertical axis, thereby imparting different roughness to different regions of the implant substrate.

[0016] In a preferred embodiment, the laser unit comprises a plurality of laser elements that irradiate laser beams of different outputs, and the implant substrate is an implant fixture substrate, and the implant fixture substrate comprises a body portion having a screw formed thereon capable of being screwed into the alveolar bone and a periodontal portion at the top of the body portion that contacts the periodontal tissue and has no screw formed thereon, and the laser elements form a nano pattern of different roughness on the screw groove and screw thread of the body portion and on the periodontal portion, wherein the roughness of the nano pattern is formed such that the screw groove is the largest, and the roughness decreases in the order of screw thread and periodontal portion.

[0017] In a preferred embodiment, the coating device fills a first coating solution mixed with the biodegradable polymer and the anti-inflammatory agent into the nano-pattern groove of the periodontal portion, and fills a second coating solution containing the biodegradable polymer and the bone formation inducer into the nano-pattern groove of the screw bone.

[0018] In a preferred embodiment, the coating machine fills the coating liquids only up to a predetermined height, rather than filling the nano-pattern grooves completely.

[0019] In a preferred embodiment, the coating device can fill the first coating liquid completely into the nano-pattern groove of the periodontal portion, and fill the second coating liquid only up to a predetermined height without filling the nano-pattern groove of the screw groove completely.

[0020] In addition, the present invention further provides a hybrid implant manufactured using the above-described hybrid implant manufacturing system, with the surface coated with a coating solution comprising a biodegradable polymer and an anti-inflammatory agent or a bone formation inducer. Effects of the invention

[0021] The present invention has the following excellent effects.

[0022] According to the hybrid implant manufacturing system and hybrid implant of the invention, roughness can be physically imparted to the surface of the implant substrate using a brush unit and a laser unit, so acid solution is not used at all for etching or cleaning, which has the advantage of eliminating concerns about acid residue being absorbed into the patient's body.

[0023] In addition, the hybrid implant manufacturing system and hybrid implant of the present invention have the advantage of controlling the release toxicity of drugs that reduce inflammation and drugs for bone formation by forming different roughnesses in different zones of the implant substrate and applying a coating that fills the roughness pattern with drugs for the periodontium and alveolar bone.

[0024] In addition, according to the hybrid implant manufacturing system and hybrid implant of the present invention, since the release rates of different drugs are controlled, the occurrence of inflammation in the early stages of implantation can be reduced and the effect of bone formation thereafter can be maximized. Brief explanation of the drawing

[0025] FIG. 1 is a configuration diagram of a hybrid implant manufacturing system according to one embodiment of the present invention, FIG. 2 is a drawing for explaining the filling state of coating liquids of a hybrid implant manufacturing system according to one embodiment of the present invention. Specific details for implementing the invention

[0026] The terms used in this invention have been selected to be as widely used as possible; however, in specific cases, terms have been arbitrarily selected by the applicant. In such cases, the meaning should be understood by considering the meaning described or used in the detailed description of the invention, rather than merely the name of the term.

[0027] Hereinafter, the technical configuration of the present invention will be described in detail with reference to preferred embodiments illustrated in the attached drawings.

[0028] However, the present invention is not limited to the embodiments described herein and may be embodied in other forms. Throughout the specification, the same reference numerals indicate the same components.

[0030] FIG. 1 is a configuration diagram of a hybrid implant manufacturing system according to one embodiment of the present invention.

[0031] Referring to FIG. 1, a hybrid implant manufacturing system according to one embodiment of the present invention is a device for manufacturing a hybrid implant that can induce bone formation and prevent inflammation in the periodontium when implanted in a human alveolar bone by forming roughness on the surface of an implant substrate, particularly an implant fixture substrate (10), without an acid etching process or an acid washing process, and filling the roughness pattern (groove) with an anti-inflammatory agent and a bone formation inducing agent to prevent inflammation.

[0032] In addition, the present invention may separately provide a hybrid implant manufactured by the said manufacturing system and coated with a drug-containing coating solution on its surface, in addition to the hybrid implant manufacturing system.

[0033] The hybrid implant manufacturing system of the present invention comprises a brush unit (100), a laser unit (200), a controller (300), and a coating machine (400), and may further include a rotary drive system (not shown) for rotating an implant filler substrate (10).

[0034] The brush unit (100) forms roughness by physically frictionally rubbing against the surface of the implant fixture substrate (10), and a plurality of brushes protruding in the horizontal direction are formed along a vertical axis (c'), which is a vertical rotation axis, and on the surface of the vertical axis.

[0035] Additionally, the vertical length of the brush unit (100) is manufactured to be similar to the vertical length of the implant fixture substrate (10), and when it rotates and comes into contact with the surface of the implant fixture substrate (10), roughness is formed on the surface of the implant fixture substrate (10) due to friction at the end of the brush.

[0036] Additionally, the brushes of the brush unit (100) are composed of three types of brushes having different strengths, and include a first brush (110) that contacts the periodontal portion (11), which is the part that contacts the periodontal tissue when implanted into the gum as the upper part of the implant fixture substrate (10); a second brush (120) that contacts the screw bone (12a) and a third brush (130) that contacts the screw thread (12b) of the body portion (12) formed at the bottom of the periodontal portion (11) and having a screw formed therein to which the alveolar bone can be screwed.

[0037] Additionally, the second brush (120) and the third brush (130) are alternately provided along the lower longitudinal direction of the brush unit (100).

[0038] That is, different types of brushes rub against the periodontal portion (11), screw groove (12a), and screw thread (12b) of the implant fixture substrate (10) to form roughness.

[0039] Additionally, the strengths of the first brush (110), the second brush (120), and the third brush (130) are different from each other, with the second brush (120) having the greatest strength, followed by the third brush (130) and then the first brush (110), in that order of strength.

[0040] That is, the roughness of the screw groove (12a) is the greatest, the roughness of the periodontal portion (11) is the smallest, and an intermediate roughness is formed on the surface of the screw thread (12b).

[0041] Additionally, the brush unit (100) may be fixed and the implant fixture substrate (10) may be rotated around a rotation axis (c) to form roughness by causing the implant fixture substrate (10) to frictionally rub against the brushes, or the brush unit (100) and the implant fixture substrate (10) may be rotated together to form roughness. In this case, the rotary drive system performs the function of rotating the implant fixture substrate (10).

[0042] However, the brush unit (100) can form an even roughness on the surface of the implant fixture substrate (10) and form different types of roughness on the periodontal portion (11), screw groove (12a), and screw thread (12b) using the laser unit (200) below.

[0043] The laser unit (200) irradiates a laser beam onto the surface of the implant fixture substrate (10) on which roughness is formed to form a nano pattern.

[0044] This nano pattern also performs the function of imparting roughness.

[0045] In addition, the laser unit (200) may include a plurality of laser elements capable of irradiating laser beams of different outputs.

[0046] Additionally, the laser unit (200) can form nano patterns of different roughness on the periodontal portion (11), the screw groove (12a), and the screw thread (12b).

[0047] More specifically, the laser unit (200) forms a nano pattern with the greatest roughness on the screw groove (12a), forms a nano pattern with the smallest roughness on the periodontal portion (11), and forms a nano pattern with medium roughness on the surface of the screw thread (12b).

[0048] Here, roughness practically refers to the depth of the groove formed on the surface of the implant fixture substrate (10).

[0049] That is, a groove is formed on the surface of the implant fixture substrate (10) by the brush unit (100) and the laser unit (200), and the depth of the groove is deepest at the screw groove (12a), and decreases in depth in the order of the screw thread (12b) and the periodontal portion (11).

[0050] This serves to control the release time of the drug charged into the home.

[0051] A detailed explanation will be provided in the description of Fig. 2.

[0052] The above controller (300) controls the operation and output of the above laser unit (200).

[0053] In addition, the controller (300) can further control the spraying of the coating liquid of the coating machine (400) described below, the rotation of the brush unit (100), and the rotation of the rotary drive system for rotating the implant fixture substrate (10).

[0054] The above coating device (400) coats the nano pattern formed on the surface of the implant fixture substrate (10) by spraying a coating solution containing a biodegradable polymer and an anti-inflammatory agent or a bone formation inducer.

[0055] Additionally, the biodegradable polymer may be PDO (Polydioxanone), PLGA (Poly lactic-co-glycolic acid), or PLLA (Poly-L-lactic acid), the anti-inflammatory agent may be chlorhexidine and silver nanomaterials, and the bone formation inducer may be rhBMP-2, but may be replaced with other known materials having substantially the same function. Additionally, the first coating solution (410) below may be a material in which chlorhexidine or silver nanomaterials are mixed with PLGA, and the second coating solution (420) below may be a material in which PLLA, rhBMP-2, and HA are mixed.

[0056] Meanwhile, the term "coating" here refers to filling the grooves of the nano-pattern with a coating solution.

[0057] In addition, the coating device (400) may be equipped with a plurality of nozzles for spraying different drugs.

[0058] Additionally, the coating device (400) fills the first coating solution, which is a mixture of the biodegradable polymer and an anti-inflammatory agent, into the nano-pattern groove of the periodontal portion (11), and fills the second coating solution, which is a mixture of the biodegradable polymer and a bone formation inducer, into the nano-pattern groove of the screw bone (12a).

[0059] Referring to FIG. 2 for a more detailed explanation, the first coating liquid (410) is filled into the nano-pattern groove (11a) of the periodontal portion (11), and the second coating liquid (420) is filled into the nano-pattern groove (12a) of the screw groove (12).

[0060] That is, the first coating liquid (410) comes into contact with the periodontal tissue to prevent initial inflammatory infection and peri-implantitis occurring in the periodontal tissue during the initial implantation period, and the second coating liquid (420) accelerates the speed of bone formation and osseointegration in the alveolar bone after the initial implantation period and performs the role of securing fixation early.

[0061] In addition, since the first coating liquid (410) must be released into the periodontium immediately during the initial implantation, it is desirable that it be filled completely into the entire periodontal nano-pattern groove (11a). Since the second coating liquid (420) must be released gradually after the initial implantation when bone formation occurs rather than during the initial implantation, it is desirable that it be filled to a certain depth (h2) relative to the depth (h2) of the screw-shaped nano-pattern groove (12a) rather than being filled completely into the entire screw-shaped nano-pattern groove (12a).

[0062] In this case, a predetermined space (12b) is provided above the second coating liquid (420) filled in the screw-shaped nano-pattern groove (12a), and the blood and the bone formation inducer of the second coating liquid (420) can react with each other in the space (12b), thereby improving the speed of bone formation and bone adhesion.

[0063] In addition, the first coating liquid (410) may not be filled to the entire length of the periodontal nano-pattern groove (11a) but may be filled to a predetermined height, which can be appropriately selected by a person skilled in the art according to the experiment.

[0064] Therefore, since the hybrid implant manufactured according to the hybrid implant manufacturing system of the present invention does not use any acid solution for etching or cleaning, there is no concern about acid residue being absorbed into the patient's body, and since the release rates of different drugs are controlled, the occurrence of inflammation in the early stages of implantation can be reduced and the effect of bone formation thereafter can be maximized.

[0066] As described above, the present invention has been illustrated and explained with reference to preferred embodiments, but it is not limited to the aforementioned embodiments, and various changes and modifications may be made by those skilled in the art within the scope of the invention without departing from the spirit of the invention. Explanation of the symbols

[0067] 100: Brush Unit 110: 1st Brush 120: 2nd Brush 130: 3rd Brush 200: Laser unit 300: Controller 400: Coating machine

Claims

Claim 1 delete Claim 2 A hybrid implant manufacturing system comprising: a brush unit that forms roughness by physically frictioning the surface of an implant substrate; a laser unit that forms a nano pattern by irradiating a laser beam onto the surface of the implant substrate after the roughness is formed by the brush unit; a controller that controls the output of the laser unit; and a coating device that coats a coating solution containing a biodegradable polymer and an anti-inflammatory agent or a bone formation inducer onto the nano pattern formed on the surface of the implant substrate; wherein the implant substrate rotates around a vertical axis or the brush unit rotates around a vertical axis and the brush end of the brush unit frictionally forms roughness on the surface of the implant substrate, and the brush unit or the laser unit imparts different roughness to different regions of the implant substrate, and the brushes of the brush unit have different intensities at different heights along the vertical axis, and the laser unit imparts different roughness to different regions of the implant substrate. Claim 3 A brush unit that forms roughness by physically frictioning the surface of an implant substrate; a laser unit that forms a nano pattern by irradiating a laser beam onto the surface of the implant substrate after the roughness is formed by the brush unit; and a controller that controls the output of the laser unit. A hybrid implant manufacturing system comprising: a coating machine that coats a coating solution containing a biodegradable polymer and an anti-inflammatory agent or a bone formation inducer onto a nano pattern formed on the surface of the implant substrate; wherein the implant substrate rotates around a vertical axis or the brush unit rotates around a vertical axis and the brush end of the brush unit frictionally forms roughness on the surface of the implant substrate, and the brush unit or the laser unit imparts different roughness to different regions of the implant substrate, and the laser unit includes a plurality of laser elements that irradiate laser beams of different outputs, wherein the implant substrate is an implant fixture substrate, and the implant fixture substrate includes a body portion having a screw formed thereon capable of being screw-fastened to the alveolar bone and a periodontal portion at the top of the body portion that contacts the periodontal tissue and does not have a screw formed thereon, and wherein the laser elements form a nano pattern of different roughness on the screw groove and screw thread of the body portion and on the periodontal portion, and wherein the roughness of the nano pattern is formed such that the screw groove is the largest, and the screw thread and periodontal portion become smaller in that order. Claim 4 A hybrid implant manufacturing system according to claim 3, wherein the coating device fills a first coating solution mixed with the biodegradable polymer and the anti-inflammatory agent into a nano-patterned groove of the periodontal portion, and fills a second coating solution containing the biodegradable polymer and the bone formation inducer into a nano-patterned groove of the screw bone. Claim 5 A hybrid implant manufacturing system according to claim 4, characterized in that the coating machine fills the coating liquids only up to a predetermined height without filling the nano-pattern grooves completely. Claim 6 A hybrid implant manufacturing system according to claim 5, wherein the coating device fills the first coating liquid completely into the nano-pattern groove of the periodontal portion, and fills the second coating liquid only up to a predetermined height without filling the nano-pattern groove of the screw groove completely. Claim 7 A hybrid implant manufactured using a hybrid implant manufacturing system according to any one of claims 2 to 6, and having a coating solution on its surface containing a biodegradable polymer and an anti-inflammatory agent or a bone formation inducer. Claim 8 delete Claim 9 delete Claim 10 delete

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