Low-dose Radiotherapy Apparatus

Abstract

According to one aspect of the present invention, a multi-gantry low-dose radiation device may be provided, comprising: a main body portion formed in the longitudinal direction of a bed in which a patient lies down to receive treatment; a radiation gantry installed on the upper side of the main body portion to move along a rail portion and irradiate a plurality of low-dose radiation toward the patient's body from the inner circumference of a ring gate; a gantry receiving portion that accommodates the radiation gantry in a standby state at one end of the main body portion; and a control portion installed on one side of the gantry receiving portion to check the patient's condition using input patient information, set a treatment direction, and then control the operation of the radiation gantry; wherein the radiation gantry is characterized by having a plurality of units installed in the longitudinal direction of the main body and being driven in conjunction or individually.

Description

Technology Field

[0001] The present invention relates to a multi-gantry low-dose radiation device, and more specifically, to a multi-gantry low-dose radiation device that can be used continuously without a rest period due to heat generated when emitting a radiation beam by installing at least one or more gantry units. Background Technology

[0002] In general, among the radiation used for medical purposes, therapeutic radiation is applied to tumors of cancer patients to prevent cancer cells from multiplying further, thereby causing the cancer cells to die after reaching the end of their lifespan or to alleviate the patient's suffering.

[0003] Recently, Intensity Modulated Radiation Therapy (IMRT) has been gaining attention as a method that utilizes a Multi-Leaf Collimator (MLC) to modulate radiation intensity to suit the shape, size, and location of the tumor, thereby reducing side effects caused by radiation in normal tissues and maximizing treatment outcomes by delivering radiation prescribed at optimal energy.

[0004] However, there was a problem in that the treatment devices used for such radiation therapy were limited to use only for cancer treatment.

[0005] In addition, conventional radiation devices had the problem that they could not emit radiation for a long time due to the heat generated when the radiation source emitted a radiation beam.

[0006] In addition, conventional radiation devices had a problem in that the number of radiation sources used was limited, making it impossible to irradiate a sufficient amount of radiation beam necessary for patient treatment. Prior art literature

[0007] Republic of Korea Registered Utility Model No. 20-0490657 The problem to be solved

[0008] The objective of the present invention is to provide a multi-gantry low-dose radiation device that can be used continuously without a rest period caused by heat generated during radiation beam emission by installing at least one or more gantry units.

[0009] Another objective of the present invention is to provide a multi-gantry low-dose radiation device that enables low-dose radiation beams to be irradiated alternately or simultaneously to a patient's body by driving a plurality of gantry individually.

[0010] Another objective of the present invention is to minimize patient inconvenience by minimizing the waiting time for the patient at the radiation device.

[0011] Another objective of the present invention is to satisfy the total amount of radiation emitted for medical treatment by increasing the number of carbon nanotube sources that emit radiation beams by a multi-gantry method.

[0012] Another objective of the present invention is to selectively provide various treatment methods by individually controlling the radiation beam emission positions of a plurality of gantry as they move along the rail section, thereby allowing radiation beams to be irradiated to multiple parts of a patient's body simultaneously or to irradiate radiation beams as they move to multiple parts of the body.

[0013] Another objective of the present invention is to minimize cell damage in the treatment area caused by radiation exposure by installing pulsed beam carbon nanotube sources around the inner periphery of the gantry so that the beam on-off time and the interval between the carbon nanotube sources are controlled to a DNA repair time capable of repairing DNA damage in normal cells.

[0014] Another objective of the present invention is to provide an optimized radiation treatment environment by adjusting the magnitude of radiation energy irradiated from a radiation device, the angle of radiation irradiation, and the radiation dose irradiated according to the treatment purpose and individual patient characteristics.

[0015] Another objective of the present invention is to provide an open radiation device that is safe for the human body by increasing the number of carbon nanotube sources that emit radiation beams by a multi-gantry method, thereby enabling a uniform beam distribution to be irradiated on a target area such as the head (brain), and by emitting low-dose, low-energy radiation beams through multiple carbon nanotube sources. means of solving the problem

[0016] According to one aspect of the present invention, a multi-gantry low-dose radiation device may be provided, comprising: a main body portion formed in the longitudinal direction of a bed in which a patient lies down to receive treatment; a radiation gantry installed on the upper side of the main body portion to move along a rail portion and irradiate a plurality of low-dose radiation toward the patient's body from the inner circumference of a ring gate; a gantry receiving portion that accommodates the radiation gantry in a standby state at one end of the main body portion; and a control portion installed on one side of the gantry receiving portion to check the patient's condition using input patient information, set a treatment direction, and then control the operation of the radiation gantry; wherein the radiation gantry is characterized by having a plurality of units installed in the longitudinal direction of the main body and being driven in conjunction or individually.

[0017] In addition, a bed in which a patient lies down to receive treatment is formed longitudinally on the upper part of the main body, the main body is provided with an open structure, and a rail section that guides the movement of a radiation gantry can be formed on the side of the main body.

[0018] In addition, a mounting bracket is formed on the lower side of one side of the main body to fix the main body at a certain height above the building floor, and the mounting bracket is installed at a position biased toward one side of the lower part of the main body so that the radiation gate can move freely toward the opposite side where the mounting bracket is not installed.

[0019] In addition, the radiation gantry may be installed in multiple numbers along the longitudinal direction of the main body, and the multiple radiation gantry may be driven in conjunction with each other or individually.

[0020] In addition, the radiation gantry forms a ring gate that surrounds the patient's torso, and a plurality of carbon nanotube sources are formed on the inner circumference of the ring gate to irradiate therapeutic radiation toward the patient's torso, and a plurality of carbon nanotube sources emitting low energy of 100 to 120 kVp (kilovolt peak) and low dose radiation of 10 to 100 cGy / min can be distributed and arranged by band.

[0021] In addition, the carbon nanotube source positioned at the center of the radiation gantry can be arranged in a left-right symmetrical structure so that the highest energy is emitted, and gradually lower energy is emitted as it descends from the center of the radiation gantry toward both ends.

[0022] In addition, an array of carbon nanotube sources can be formed in multiple rows around the inner circumference of the gate of the radiation gantry, and each of the carbon nanotube source arrays can be operated alternately.

[0023] In addition, the gantry receiving portion is provided as a ring-shaped structure that encloses the outer shape of the radiation gantry and accommodates the radiation gantry in an operating standby state, and may form a table for installing a control unit at one open end.

[0024] In addition, the gantry receiving portion can be formed as an independent structure that is electrically and mechanically connected to the main body, or electrically connected while being mechanically separated.

[0025] In addition, the control unit may include an input device for inputting commands to control a monitor and device capable of monitoring patient information.

[0026] In addition, the above control unit can be formed as a touch panel. Effects of the invention

[0027] The present invention enables continuous use without rest periods caused by heat generated during radiation beam emission by installing at least one or more gantry units, and by enabling multiple gantry units to be driven individually, low-dose radiation beams can be irradiated to a patient's body alternately or simultaneously.

[0028] The present invention can minimize patient inconvenience by minimizing the time a patient spends waiting at a radiation device.

[0029] The present invention can increase efficiency by increasing the number of carbon nanotube sources that emit radiation beams by a multi-gantry method, thereby satisfying the total amount of radiation emitted for medical treatment.

[0030] The present invention allows the radiation beam emission positions of a plurality of gantry to be individually controlled while moving along a rail section, thereby enabling radiation beams to be irradiated to multiple parts of a patient's body simultaneously or to be irradiated to multiple parts of the body while moving, thus selectively providing various types of medical treatment.

[0031] The present invention can provide an optimized radiation treatment environment by adjusting the magnitude of radiation energy irradiated from a radiation device, the angle of radiation irradiation, and the radiation dose irradiated according to the treatment purpose and individual patient characteristics.

[0032] The present invention can irradiate a target such as the head (brain) area with a uniform beam distribution by increasing the number of carbon nanotube sources that emit radiation beams by a multi-gantry method, and can provide a safe and efficient environment for the human body by emitting low-dose, low-energy radiation beams through multiple carbon nanotube sources. Brief explanation of the drawing

[0033] FIG. 1 is a perspective view illustrating a multi-gantry low-dose radiation device according to the present invention. FIG. 2 is a side view illustrating a multi-gantry low-dose radiation device according to the present invention. FIG. 3 is an exemplary diagram of the gantry operation state of a multi-gantry low-dose radiation device according to the present invention. FIG. 4 is an example diagram of the arrangement of carbon nanotube sources in a multi-gantry low-dose radiation device according to the present invention. Figure 5 is a graph showing the progress of drug treatment and combined radiation therapy on experimental mice according to the conventional method. FIG. 6 is a graph showing the progress of parallel treatment on experimental mice according to the low-dose radiation device of the present invention. Figure 7 shows the results of radiation therapy using the conventional method. Aβ A graph comparing cortical images and the number of plaques per unit area with a control group. FIG. 8 is a result of low-dose radiation therapy according to the present invention. Aβ A graph comparing cortical images and the number of plaques per unit area with a control group. Figure 9 is a graph comparing the results of radiation therapy using the conventional method with the relative expression of the control group via RT-PCR. Figure 10 is a graph comparing the relative expression of the low-dose radiation therapy results of the present invention with that of a control group via RT-PCR. Specific details for implementing the invention

[0034] Hereinafter, embodiments will be described in detail with reference to the attached drawings. However, the scope of the patent application is not limited or restricted by these embodiments. Identical reference numerals in each drawing indicate identical components.

[0035] FIG. 1 is a perspective view illustrating a multi-gantry low-dose radiation device according to the present invention, FIG. 2 is a side view illustrating a multi-gantry low-dose radiation device according to the present invention, FIG. 3 is an example diagram of the gantry operation state of the multi-gantry low-dose radiation device according to the present invention, and FIG. 4 is an example diagram of the carbon nanotube source arrangement of the multi-gantry low-dose radiation device according to the present invention.

[0036] Referring to FIGS. 1 to 3, the low-dose radiation device (10) according to the present invention may largely include a main body (110), a radiation gantry (120, 120'), a gantry receiving part (130), and a control part (140).

[0037] A bed (111) on which a patient lies down to receive treatment may be formed longitudinally on the upper part of the main body (110).

[0038] At this time, the main body (110) is provided with an open structure, which can provide an environment where the patient can communicate with the outside. Such an open structure can prevent the patient from having a fear of being enclosed and can alleviate concerns regarding radiation exposure.

[0039] A rail section (112) that guides the movement of a radiation gantry (120, 120') can be formed on the side of the main body (110).

[0040] The above rail section (112) is installed on the transport path of the radiation gantry (120, 120') and can support the lower part of the radiation gantry (120, 120') so as to be slidably driven.

[0041] The above rail portion (112) can be installed on the left and right sides in the longitudinal direction of the main body portion (110), respectively.

[0042] Such a rail section (112) may be composed of a fixed rail (not shown) inside the main body section (110), a rail guide (not shown) coupled to the fixed rail and sliding thereon, and a driving section (not shown) that reciprocates the rail guide in the direction of the rail. At this time, the driving section may use an actuator, such as a motor and a hydraulic cylinder, as a power source.

[0043] As the above rail guide is combined with the radiation gantry (120, 120'), the radiation gantry (120, 120') can be reciprocated together with the rail guide when the drive unit operates.

[0044] At this time, the rail guide and drive unit may be installed in varying numbers depending on the number of radiation gantry installed.

[0045] In addition, a radiation detector (not shown) may be formed inside the main body (110). The radiation detector is a detection device that detects radiation that has passed through a subject (patient).

[0046] In addition, the signal detected through the radiation detector described above can be provided as an image or screen through the monitor (141) of the control unit (140) to be described later.

[0047] Additionally, a mounting bracket (113) may be formed on the lower side of one side of the main body (110) to fix the main body (110) in a state where it is suspended at a certain height from the floor of the building. The mounting bracket (113) may be configured to have electrical equipment, control equipment, and communication equipment installed inside for driving the ionizing radiation device.

[0048] At this time, the mounting bracket (113) can be installed at a position that is biased and offset to one side of the lower part of the main body (110). Accordingly, the radiation gate can be freely moved to the opposite side where the mounting bracket (113) is not installed.

[0049] And, a radiation gantry that moves along a rail section may be installed on the upper side of the main body (110).

[0050] The above radiation gantry (120, 120') can form a ring gate (121) and allow a plurality of low-dose radiation to be irradiated toward the patient's body from the inner circumference of the ring gate (121).

[0051] At this time, the radiation gantry (120, 120') is installed in multiple numbers along the longitudinal direction of the main body (110), and the multiple radiation gantry (120, 120') can be driven in conjunction with each other or individually.

[0052] Hereinafter, regarding the radiation gantry (120, 120'), the radiation gantry (120, 120') forms a ring gate (121) that surrounds the patient's torso. At this time, a plurality of carbon nanotube sources (123) are formed on the inner circumference of the ring gate (121) to allow therapeutic radiation to be irradiated toward the patient's torso.

[0053] More specifically, a plurality of carbon nanotube sources (123) emitting low-energy radiation of 100-120 kVp (kilovolt peak) and low-dose radiation of 10-100 cGy / min can be distributed and arranged in different bands around the inner circumference of the radiation gantry (120, 120').

[0054] In this context, low-dose radiation (LDR) refers to radiation of low intensity, which is the ordinary kind found in nature. While large amounts of radiation can be harmful to living organisms, small amounts of low-dose radiation can actually stimulate physiological activity in living organisms, thereby extending their lifespan, promoting growth, or reducing the incidence of tumors; this phenomenon is called radiation hormesis.

[0055] It has been reported that low-dose radiation in the miligray (mGy) range, unlike high-dose radiation, induces resistance to disease and exhibits adaptive protection effects (Sakai K., et al., Dose Response, 2006, 4(4):327~332; Sakai K., et al, Int. J. Low Radiat., 2003, 1(1):142~146; Scott BR., Dose Response, 2008 6(3):299~318), and there is a report that the condition of experimental mice with diabetes genes improved when irradiated with a certain amount of low-dose radiation (Sakai K., et al., Dose Response, 2006, 4(4):327~332). It is known that radiation of 0.25 Gy or less has the effect of protecting against DNA damage and repairing damaged DNA (Le XC., et al., Science, 1998, 280(5366):1066~1069), and that low-dose radiation has an immune-enhancing effect (Nogami M., et al., Int. J. Radiat. Biol., 1993, 63(6):775~783; Nogami M., et al., Radiat. Res., 1994, 139(1):47~52).

[0056] Referring to FIG. 4, the highest energy can be emitted from the carbon nanotube source (123) positioned at the center of the radiation gantry (120, 120'), and gradually lower energy can be emitted as it goes down toward both ends starting from the center of the radiation gantry (120, 120').

[0057] For example, if the carbon nanotube source (310) is arranged radially in 10 places as shown in FIG. 4, a pair of carbon nanotube sources (123) installed at two central symmetric points may each emit 300 KVP of energy, a carbon nanotube source (123) symmetrically positioned below them may each emit 200 KVP of energy, a pair of carbon nanotube sources (123) symmetrically positioned below them may each emit 100 KVP of energy, a pair of carbon nanotube sources (123) symmetrically positioned below them may each emit 50 KVP of energy, and a pair of carbon nanotube sources (123) symmetrically positioned below them may each emit 10 KVP of energy.

[0058] When carbon nanotube sources (123) are arranged in a left-right symmetrical structure like this, it is possible to irradiate a body structure that is most suitable for a left-right symmetrical structure centered on the torso. In particular, major organs are concentrated in the torso of the body, and since they are protected by thick subcutaneous fat and muscles, it is necessary to irradiate a relatively high-energy radiation beam, while sufficient effects can be expected by irradiating the arms and legs of the body with a relatively low-energy radiation beam.

[0059] In addition, a plurality of rows of carbon nanotube sources (123) may be formed around the inner circumference of the gate of the radiation gantry (120, 120'), and each of the carbon nanotube source (123) rows may be operated alternately.

[0060] For example, if the arrangement of the carbon nanotube sources (123) is formed in two rows, after the radiation of the carbon nanotube sources (123) in one row is sequentially carried out, the carbon nanotube sources (123) in one row are put in a standby state, and the radiation of the carbon nanotube sources (123) in two rows that are waiting for treatment is sequentially carried out so that radiation therapy can proceed.

[0061] In this way, by alternately performing radiation therapy with 1 and 2 rows of carbon nanotube sources (123), the treatment time can be shortened and intensive radiation therapy can be achieved.

[0062] The above radiation gantry (120, 120') is installed in multiple numbers along the longitudinal direction of the main body (110), and the multiple radiation gantry (120, 120') can be driven in conjunction with each other or individually.

[0063] For example, multiple radiation gantry units (120, 120') can be connected to simultaneously irradiate one part of a patient's body intensively or irradiate two or more parts of a patient's body simultaneously.

[0064] In addition, among the multiple radiation gantry (120, 120'), only a specific radiation gantry (120, 120') can be selectively operated or only a specific radiation gantry (120, 120') can be deactivated.

[0065] In addition, each of the above radiation gantry (120, 120') can cause multiple rows of carbon nanotube sources (123) installed around the inner circumference of the gate to operate alternately.

[0066] At this time, the carbon nanotube sources (123) can each operate individually or in a thermal unit.

[0067] According to the present invention described above, by installing at least one or more radiation gantry (120, 120') in a plurality, continuous use is possible without a rest period due to heat generated when emitting a radiation beam, and by enabling the plurality of radiation gantry (120, 120') to be operated in conjunction or individually, low-dose radiation beams can be irradiated to the patient's body alternately or simultaneously, which minimizes the patient's waiting time at the radiation device, thereby minimizing the patient's discomfort.

[0068] In addition, the present invention can satisfy the total amount of radiation emitted for medical treatment by increasing the number of carbon nanotube sources that emit radiation beams by a multi-gantry method, and by individually controlling the radiation beam emission positions of multiple gantry units as they move along a rail section, it is possible to selectively provide various types of medical treatment by irradiating radiation beams to multiple parts of a patient's body simultaneously or by irradiating radiation beams while moving to multiple parts of the body.

[0069] The present invention enables a therapeutic effect by irradiating a radiation beam to a target sensitive to radiation exposure, such as the head (brain) area, by emitting a low-dose, low-energy radiation beam through a carbon nanotube source. Furthermore, in order to irradiate a uniform beam distribution to the head (brain) area, it is necessary to increase the number of carbon nanotube sources that emit radiation beams using a multi-gantry method as in the present invention.

[0070] According to the radiation device using the multi-gantry method of the present invention, a uniform beam distribution targeting a target such as the head (brain) area can be irradiated safely and efficiently.

[0071] In addition, according to the present invention, by alternating operation of a plurality of carbon nanotube sources, the decrease in durability of the carbon nanotube sources due to heat generation during radiation beam emission can be compensated for, and the advantage of continuous use without a rest period caused by the heat generated during radiation beam emission can be provided.

[0072] And, a gantry receiving portion (130) may be formed at one end of the main body portion (110).

[0073] The above gantry receiving portion (130) is a component that allows the radiation gantry (120, 120') to be received in an operational standby state, and can be provided as a ring-shaped structure that surrounds the outer shape of the radiation gantry (120, 120').

[0074] At this time, the gantry receiving portion (130) may be provided in a complete ring shape, but as shown in FIGS. 1 to 3, it may be provided in a ring shape with one side open. At this time, a table (131) for installing a control portion (140) may be formed at the open end.

[0075] The table (131) can be formed by extending the open end of the gantry receiving portion (130) in the transverse direction.

[0076] At this time, the gantry receiving part (130) can be electrically and mechanically connected to the main body part (110).

[0077] However, it is not limited to this, and can be formed as an independent structure that is electrically connected but mechanically separated. For example, such a separation structure allows only the control unit (140) and the gantry receiving unit (130) to be separated from the main body (110) and replaced when upgrading the radiation device.

[0078] Meanwhile, the present invention may provide a control unit (140) that selectively controls the carbon nanotube source (123), checks the patient's condition using input patient information and sets the treatment direction, and then controls the operation of the low-dose radiation device (10) to perform radiation therapy.

[0079] The above control unit (140) may include a monitor (141) capable of monitoring patient information and an input device (143) for inputting commands to control the device. In this case, the monitor (141) and the input device (143) may be replaced with a touch panel.

[0080] In the present invention, a selective treatment mode according to the type of disease and the patient's condition can be set through the control unit (140).

[0081] For example, there is a need to vary the intensity and irradiation band of the radiation used for treatment, and to achieve this, a specific band of carbon nanotube source (123) among a plurality of carbon nanotube sources (123) divided by band can be selectively activated, or two or more carbon nanotube sources (123) can be activated simultaneously to enable complex treatment.

[0082] This allows for the operation of various treatment modes by pre-setting them based on the patient's age or health condition, and enables the selective operation of multiple carbon nanotube sources according to the set treatment mode and the total amount and frequency of radiation irradiated to be controlled in combination through the operation of the control unit (140).

[0083] In particular, when a patient lies on the bed (100) and waits for treatment, the control unit (140) checks the patient's condition through pre-entered patient information and sets the treatment direction, and then, according to the judgment of the control unit (140), drives the bed (100) to position the patient in an optimal treatment position, and then drives the radiation gantry (120, 120') to perform radiation therapy.

[0084] The control unit (140) can be installed on the outside of the gantry receiving unit (130) to make it convenient for the operator to operate.

[0085] The carbon nanotube source (123) used in the present invention may be a carbon nanotube X-ray source comprising a metal emitter and a CNT (carbon nanotube) grown in the emitter.

[0086] At this time, the CNT (carbon nanotube) emits electrons by means of field emission and can be formed in an irregular shape facing upward on the top of the pad, and the growth process of the CNT can utilize a Plasma Enhanced Chemical Vapor Deposition (PECVD) process or a Thermal Chemical Vapor Deposition (Thermal CVD) process that supplies hydrocarbon gas.

[0087] Figure 5 is a graph showing the progress of drug treatment and combined radiation therapy on experimental mice according to the conventional method.

[0088] Referring to Figure 5, when drug treatment, radiation therapy, and ATB2005 treatment were combined on 12-week-old experimental mice according to the conventional method, the experimental mice survived until week 6. This is the result of administering drug treatment three times a week for 6 weeks, radiation therapy at 50 cGy x 5 times, and ATB2005 treatment at 10 mpk IP TIW x 6 weeks.

[0089] Figure 6 is a graph showing the progress of parallel treatment on experimental mice according to the low-dose radiation device of the present invention.

[0090] Referring to FIG. 6, according to the low-dose radiation device of the present invention, 12-week-old experimental mice were subjected to ATC-108 (10 mpk) treatment at intervals of 3 times per week for 8 weeks for a total of 24 times, and radiation therapy was administered at intervals of 2 times per week for 2.5 weeks for a total of 5 times with low-dose radiation of 100–300 kVp and 60 cGy, and the experimental mice showed results of surviving until week 31.

[0091] When comparing the experimental results according to the conventional method in Fig. 5 (6 weeks survival) and the experimental results according to the low-dose radiation device of the present invention in Fig. 6 (31 weeks survival), it was seen that the survival rate of mice in the low-dose radiation device of the present invention was significantly higher.

[0092] Figure 7 shows the results of radiation therapy using the conventional method. Aβ This is a graph comparing cortical images and the number of plaques per unit area (mm³) with a control group, and FIG. 8 is a graph showing the results of low-dose radiation therapy according to the present invention. Aβ This is a graph comparing cortical images and the number of plaques per unit area (mm³) with a control group.

[0093] Referring to Figures 7 and 8, Figure 7 shows the results of treatment using conventional 6 MeV radiation, and according to this, compared to the control group (Vehicle) that did not receive radiation therapy, it can be seen that the number of plaques per unit area (mm³) was not significantly reduced at a ratio of 28 to 22.

[0094] In contrast, Figure 8 shows the results of low-dose radiation therapy according to the present invention, that is, the results of treatment using 300 kVp radiation. Compared to the control group (Vehicle) that did not receive radiation therapy, the number of plaques per unit area (mm³) was significantly reduced in a ratio of 140 to 70.

[0095] As a result of comparing the control groups in Figures 7 and 8 above, when irradiated with the low-dose radiation of the present invention in kVp units, the reduction in the number of plaques per area (mm³) was greater than when irradiated with radiation in MeV units according to the conventional method. At this time, the number of plaques is amyloid beta ( Aβ) It is related to radiation therapy as it involves staining cells.

[0096] Figure 9 is a graph comparing the results of radiation therapy using the conventional method with the relative expression of the control group via RT-PCR, and Figure 10 is a graph comparing the results of low-dose radiation therapy using the present invention with the relative expression of the control group via RT-PCR.

[0097] As shown in Figure 9, RT-PCR_TNF-α and RT-PCR_IL-6 were performed on the results of conventional radiation therapy, and the results showed that the relative expression ratios with the control group were 1:1 and 1:0.8, respectively, indicating that there was almost no difference in ratio.

[0098] As shown in Figure 10, RT-PCR_TNF-α and RT-PCR_IL-6 were performed on the results of the low-dose radiation therapy of the present invention, respectively, and as a result, the relative expression ratios with the control group were 1.2 : 0.6 and 1 : 0.1, respectively, showing a ratio difference of more than 2 times.

[0099] Recently, several preclinical and exploratory clinical study papers have reported that low-dose radiation has anti-inflammatory and neuroprotective effects, which are explained by a mechanism that inhibits the NFkb pathway and regulates microglia phenotypes.

[0100] A study reported that 75% of 3 out of 4 patients with clinically advanced dementia showed remarkable improvement in cognitive function after undergoing 3 sessions of 120 kVp X-ray energy (brain computed tomography CT) for a total of 16 cGy (Source: low dose of ionizing radiation as a treatment for alzheimer's disease : journal of alzheimer's disease 2021).

[0101] In addition, research results have been reported showing that in patients with osteoarthritis, the pain-reducing therapeutic effect was 13-21% superior when using 120-300 kVp, where photoelectric effects are dominant, compared to when using radiation in the region where Compton effects (6 MeV) are dominant (Source: Strahlentherapie und Onkologie volume 196, pages 715-724 (2020).

[0102] Previous studies have reported that when irradiated with the same dose of radiation, telomere shortening is not significantly affected by the quality of radiation (electrons, protons, alpha particles), but the biological effects on chromosome abberation and apoptosis are significantly greater with high LET protons and heavy ions compared to low LET radiation.

[0103] Therefore, when comparing the radiobiological effects when using radiation in the 120-300 kVp range, where the photoelectric effect is dominant physically, and the Compton effect (6 MeV), the RBE (RadioBiologic Effect) is twice as large at 120-300 kVp as at 6 MeV (2 to 1), and it can be predicted that the energy at 120-300 kVp, where energy dissipates rapidly, is more effective in biological effects in the low-dose range, particularly in cell protection and anti-inflammatory effects.

[0104] As described above, the present invention allows for continuous use without a rest period caused by heat generated during radiation beam emission by installing at least one or more gantry units, and by enabling the multiple gantry units to be driven individually, low-dose radiation beams can be irradiated to the patient's body alternately or simultaneously. Furthermore, by enabling the radiation beam emission positions of the multiple gantry units to move along the rail section and be individually controlled, radiation beams can be irradiated to multiple parts of the patient's body simultaneously or moved to irradiate multiple parts of the body, thereby selectively providing various treatment forms. This allows for the adjustment of the magnitude of radiation energy irradiated from the radiation device, the angle of radiation irradiation, and the radiation dose irradiated according to the treatment purpose and individual patient characteristics, thereby providing an optimized radiation treatment environment.

[0105] Although the embodiments have been described above with reference to the limited drawings, those skilled in the art can make various modifications and variations from the description above. For example, suitable results can be achieved even if the described techniques are performed in a different order than described, and / or the components of the described system, structure, device, circuit, etc. are combined or assembled in a form different from described, or replaced or substituted by other components or equivalents.

[0106] Therefore, other implementations, other embodiments, and equivalents to the claims also fall within the scope of the claims set forth below. Explanation of the symbols

[0107] 10: Low-dose radiation device 110: Main body 111: Bed 112: Rail section 113: Mount 120,120': Radiation Gantry 121: Ring gate 123: Carbon nanotube source 130: Gantry Reception 131: Table 140: Control unit 141: Monitor 143: Input device

Claims

Claim 1 A main body portion forming a bed in which a patient lies down to receive treatment; and a radiation gantry installed to move along the upper side of the main body portion and irradiate a plurality of low-dose radiations toward the patient's body from the inner circumference of a ring gate; and a gantry receiving portion that accommodates the radiation gantry in an operational standby state at one end of the main body portion; and a control unit installed on one side of the gantry receiving part, which checks the patient's condition using inputted patient information, sets the treatment direction, and controls the operation of the radiation gantry; wherein the radiation gantry is installed in multiple units along the longitudinal direction of the main body and is driven in conjunction with each other or individually, and the radiation gantry includes a ring gate formed to surround the patient's torso, and a plurality of carbon nanotube sources are formed on the inner circumference of the ring gate to irradiate therapeutic radiation toward the patient's torso, and the carbon nanotube sources are formed to emit low-energy radiation of 100-120 kVp (kilovolt peak) and low-dose radiation of 10-100 cGy / min, and are arranged on the inner circumference of the ring gate in a distributed form according to multiple bands, and a carbon nanotube source emitting the highest energy among the carbon nanotube sources is arranged in the center of the radiation gantry, and carbon nanotube sources emitting gradually lower energy from the center toward both ends are arranged on both sides of the radiation gantry. A multi-gantry low-dose radiation device characterized by Claim 2 A multi-gantry low-dose radiation device according to claim 1, characterized in that the bed is formed longitudinally on the upper part of the main body, the main body is provided with an open structure, and a rail portion is formed on the side of the main body to guide the movement of the radiation gantry. Claim 3 A multi-gantry low-dose radiation device according to claim 2, characterized in that a mounting bracket is formed on the lower side of one side of the main body to fix the main body at a certain height above the building floor, and the mounting bracket is installed at a position biased toward one side of the lower part of the main body so as to allow free movement of the radiation gate to the opposite side where the mounting bracket is not installed. Claim 4 delete Claim 5 delete Claim 6 A multi-gantry low-dose radiation device according to claim 1, characterized in that the carbon nanotube sources are arranged in a left-right symmetrical structure on both sides of the radiation gantry with respect to the center of the radiation gantry. Claim 7 A multi-gantry low-dose radiation device according to claim 6, characterized in that an array of carbon nanotube sources is formed in multiple rows around the inner circumference of the gate of the radiation gantry, and each array of carbon nanotube sources is operated alternately. Claim 8 A multi-gantry low-dose radiation device according to claim 1, wherein the gantry receiving portion is provided as a ring-shaped structure that encloses the outer shape of the radiation gantry and accommodates the radiation gantry in an operating standby state, and a table for installing a control unit is formed at one open end. Claim 9 A multi-gantry low-dose radiation device according to claim 8, characterized in that the gantry receiving portion is electrically and mechanically connected to the main body portion, or is formed as an independent structure that is electrically connected while being mechanically separated. Claim 10 A multi-gantry low-dose radiation device according to claim 1, characterized in that the control unit includes a monitor capable of monitoring patient information and an input device for inputting commands to control the device. Claim 11 A multi-gantry low-dose radiation device characterized in that, in claim 10, the control unit is formed as a touch panel.

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