Device and method for determining which organ problem exists at the time of stimulus recognition
Patent Information
- Application Number
- KR1020250013630
- Authority / Receiving Office
- KR · KR
- Patent Type
- Patents
- Current Assignee / Owner
- Filing Date
- 2025-02-04
- Publication Date
- 2026-09-18
- Estimated Expiration
- 2042-06-14
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Figure 112025012384324-PAT00002_ABST
Abstract
Description
Technology Field
[0001] The present disclosure relates to an apparatus and method for determining an organ where a problem exists at the time of stimulus perception. Background Technology
[0002] Balance is the result of the integrated and organic working of various sensory organs, and it is impossible to reflect the entirety of balance function based solely on the functional evaluation of a single sensory organ.
[0003] Even in cases of dizziness caused by balance disorders, it is impossible to fully explain the etiology based solely on the vestibular function of the inner ear.
[0004] To elucidate the etiology of dizziness, research on multi-sensory integration for maintaining balance is necessary.
[0005] While research on the spatial integration of various senses in balance function is actively being conducted, research on temporal integration is severely lacking.
[0006] Research is needed on how multi-sensory temporal integration affects the maintenance of balance and the occurrence of dizziness in the human body. Prior art literature
[0007] Republic of Korea Published Patent Application 10-2019-0028358 (Published March 18, 2019) The problem to be solved
[0008] The embodiments disclosed in this disclosure provide a method and apparatus for identifying the cause of dizziness using galvanic vestibular stimulation, which is capable of identifying the cause of dizziness in terms of temporal integration.
[0009] The problems that this disclosure aims to solve are not limited to those mentioned above, and other unmentioned problems will be clearly understood by a person skilled in the art from the description below. means of solving the problem
[0010] A method for identifying the cause of dizziness using galvanic vestibular stimulation according to one aspect of the present disclosure for solving the above-mentioned problem comprises: applying a plurality of different types of stimuli that stimulate sensory organs related to balance function; measuring the time difference in which the plurality of stimuli are perceived in the cerebrum using a psychophysical method; determining a time combination window and perceived subjective synchronicity based on the measured time difference; and determining the cause of dizziness by analyzing the discrepancy of temporal integration based on at least one of the time combination window and perceived subjective synchronicity.
[0011] In an embodiment, the plurality of different types of stimuli are characterized by including galvanic vestibular stimulation, visual stimulation, and vibrational stimulation.
[0012] In an embodiment, the galvanic vestibular stimulation is characterized by applying stimulation to the vestibular system, the visual stimulation is characterized by applying stimulation to the visual system, and the vibration stimulation is characterized by applying stimulation to the somatosensory system.
[0013] In an embodiment, the application step is characterized by applying two stimuli among galvanic vestibular stimulation, visual stimulation, and vibration stimulation at a predetermined time interval.
[0014] In an embodiment, the applying step is characterized by selecting any two stimuli among galvanic vestibular stimulation, visual stimulation, and vibration stimulation, applying the two selected stimuli multiple times at predetermined time intervals, and the predetermined time intervals being variable.
[0015] In an embodiment, the measuring step is characterized by measuring the time difference between the points in time when each stimulus is perceived for two stimuli applied multiple times at a predetermined time interval.
[0016] In an embodiment, if the measured time difference relative to a predetermined time interval for applying the two stimuli is greater than or equal to a reference value, the method further includes the step of determining the organ in which there is a problem with perception among galvanic vestibular stimulation, visual stimulation, and vibration stimulation.
[0017] In an embodiment, the method further includes the step of conducting a training program for the organ having a cognitive problem using any one of galvanic vestibular stimulation, visual stimulation, and vibration stimulation to stimulate the organ having a cognitive problem.
[0018] A dizziness cause identification device according to another aspect of the present disclosure includes a stimulus input unit that applies a plurality of different types of stimuli to sensory organs related to balance function, and a control unit that measures the time difference in which the plurality of stimuli are perceived in the cerebrum by a psychophysical method, determines a time combination window and perceived subjective synchronicity based on the measured time difference, and determines the cause of dizziness by analyzing the discrepancy of temporal integration based on at least one of the time combination window and perceived subjective synchronicity.
[0019] In an embodiment, the plurality of different types of stimuli are characterized by including galvanic vestibular stimulation, visual stimulation, and vibrational stimulation.
[0020] In an embodiment, the galvanic vestibular stimulation is characterized by applying stimulation to the vestibular system, the visual stimulation is characterized by applying stimulation to the visual system, and the vibration stimulation is characterized by applying stimulation to the somatosensory system.
[0021] In an embodiment, the stimulation input unit is characterized by applying two stimuli among galvanic vestibular stimulation, visual stimulation, and vibration stimulation at a predetermined time interval.
[0022] In an embodiment, the stimulation input unit selects any two stimuli among galvanic vestibular stimulation, visual stimulation, and vibration stimulation, applies the two selected stimuli multiple times at a predetermined time interval, and the predetermined time interval is variable.
[0023] In an embodiment, the control unit is characterized by measuring the time difference between the points in time when each stimulus is recognized for two stimuli applied multiple times at a predetermined time interval.
[0024] In an embodiment, the control unit is characterized by determining which organ has a problem with perception among galvanic vestibular stimulation, visual stimulation, and vibration stimulation when the measured time difference relative to a predetermined time interval for applying the two stimuli is greater than or equal to a reference value.
[0025] In an embodiment, the control unit is characterized by conducting a training program for the organ having a cognitive problem by using one of the galvanic vestibular stimulation, visual stimulation, and vibration stimulation to stimulate the organ having a cognitive problem.
[0026] In addition to this, other methods for implementing the present disclosure, other systems, and computer-readable recording media for recording a computer program for executing said method may be further provided.
[0027] Other specific details of the present disclosure are included in the detailed description and drawings. Effects of the invention
[0028] According to the present disclosure, a new etiology of dizziness can be identified by analyzing the inner ear vestibular system, visual system, and somatosensory system involved in maintaining balance in terms of time.
[0029] The effects of the present disclosure are not limited to those mentioned above, and other unmentioned effects will be clearly understood by a person skilled in the art from the description below. Brief explanation of the drawing
[0030] FIG. 1 is a conceptual diagram illustrating a device for identifying the cause of dizziness according to the present disclosure. FIG. 2 is a flowchart illustrating a method for identifying the cause of dizziness according to the present disclosure. Figures 3 and 4 are conceptual diagrams to explain the method examined in Figure 2. Specific details for implementing the invention
[0031] Throughout this disclosure, the same reference numerals denote the same components. This disclosure does not describe all elements of the embodiments, and general content in the art to which this disclosure pertains or content that overlaps between embodiments is omitted. The terms 'part, module, component, block' as used in the specification may be implemented in software or hardware, and depending on the embodiments, a plurality of 'parts, modules, components, blocks' may be implemented as a single component, or a single 'part, module, component, block' may include a plurality of components.
[0032] Throughout the specification, when a part is described as being "connected" to another part, this includes not only cases where they are directly connected but also cases where they are indirectly connected, and indirect connections include connections made via a wireless communication network.
[0033] Furthermore, when it is stated that a part "includes" a certain component, this means that, unless specifically stated otherwise, it does not exclude other components but may include additional components.
[0034] Throughout the specification, when it is stated that a component is located "on" another component, this includes not only cases where a component is in contact with another component, but also cases where another component exists between the two components.
[0035] Terms such as "first," "second," etc., are used to distinguish one component from another, and the components are not limited by the aforementioned terms.
[0036] Singular expressions include plural expressions unless there is an obvious exception in the context.
[0037] In each step, identification codes are used for convenience of explanation and do not describe the order of the steps; the steps may be performed differently from the specified order unless a specific order is clearly indicated in the context.
[0038] The operating principles and embodiments of the present disclosure will be described below with reference to the attached drawings.
[0039] The method for determining the cause of dizziness described in this specification may be implemented by a device or computer for determining the cause of dizziness.
[0040] For example, the ‘dizziness cause identification device’ may include not only computers, desktop computers, and laptop computers, but also smartphones, tablet PCs, cellular phones, PCS phones (Personal Communication Service phones), synchronous / asynchronous IMT-2000 (International Mobile Telecommunication-2000) mobile terminals, Palm PCs (Palm Personal Computers), and Personal Digital Assistants (PDAs).
[0041] In addition, the 'dizziness cause identification device' can communicate with a server that receives a request from a client and performs information processing.
[0042] In addition, a dizziness cause identification device according to one embodiment of the present disclosure may be a server capable of communicating with various institutions or client devices.
[0043] In addition, the dizziness cause identification device according to one embodiment of the present disclosure may be a mobile terminal.
[0044] The mobile terminals described in this specification may include mobile phones, smartphones, laptop computers, digital broadcasting terminals, personal digital assistants (PDAs), portable multimedia players (PMPs), navigation systems, slate PCs, tablet PCs, ultrabooks, wearable devices (e.g., smartwatches, smart glasses, head-mounted displays (HMDs)), etc.
[0045] Hereinafter, for convenience of explanation, the terms "dizziness cause identification device" and "computer (or server)" will be used interchangeably in this specification. Furthermore, the above method for identifying the cause of dizziness can be understood as being performed by the above dizziness cause identification device or computer (or server).
[0046] FIG. 1 is a conceptual diagram for explaining an apparatus for identifying the cause of dizziness according to the present disclosure. FIG. 2 is a flowchart for explaining a method for identifying the cause of dizziness according to the present disclosure, and FIG. 3 and FIG. 4 are conceptual diagrams for explaining the method examined in FIG. 2.
[0047] Referring to FIG. 1, the dizziness cause identification device (100) of the present disclosure may include a stimulation input unit (110), a memory (120), and a control unit (130).
[0048] The above stimulus input unit (110) can apply multiple stimuli of different types that stimulate sensory organs related to balance function.
[0049] For example, the above-mentioned multiple stimuli of different types may include galvanic vestibular stimulation, visual stimulation, and vibrational stimulation.
[0050] Galvanic vestibular stimulation can apply stimulation to the vestibular system (or inner ear vestibular system), visual stimulation can apply stimulation to the visual system, and vibratory stimulation can apply stimulation to the somatosensory system.
[0051] The stimulation input unit (110) may include a Galvanic vestibular stimulation (GVS) system for applying galvanic vestibular stimulation to a user.
[0052] Additionally, the stimulation input unit (110) may include a VR visual stimulation system for applying visual stimulation. To apply the visual stimulation, the stimulation input unit may use a glasses type or a Pupil VR composed of two cameras and four IR LEDs.
[0053] Additionally, the stimulation input unit (110) may include a vibration generating device for applying vibration stimulation.
[0054] This stimulus input unit (110) can be operated and controlled by the control unit (130).
[0055] The memory (120) is electrically connected to the control unit (130). The memory (120) can store basic data for the unit, control data for controlling the operation of the unit, and input / output data. The memory (220) can be a hardware storage device such as ROM, RAM, EPROM, flash drive, hard drive, etc. The memory (120) can store various data for the overall operation of the dizziness cause identification device (100), such as a program for processing or controlling the control unit (130).
[0056] In addition to operations related to the application program, the control unit (130) typically controls the overall operation of the dizziness determination device (100). The control unit (130) can provide or process appropriate information or functions to the user by processing signals, data, information, etc. that are input or output through the components described above, or by running an application program stored in memory.
[0057] Referring to Figure 3, the balance function of the human body is achieved through the integration of information (multisensory integration) from three sensory organs (inner ear vestibular / visual / somatosensory).
[0058] Multisensory integration can be analyzed by distinguishing it into spatial integration and temporal integration.
[0059] As illustrated in Fig. 4, as an example of multisensory integration, the temporal integration of visual and auditory stimuli regarding lightning can be considered.
[0060] In other words, the multi-sensory temporal integration of various senses involved in balance can affect the maintenance of balance and the occurrence of dizziness.
[0061] Since not only the spatial integration but also the temporal integration of various senses involved in balance influences the occurrence of dizziness, the present disclosure may reveal new etiologies in various dizziness disorders for which the causes of symptoms have not been identified by existing clinical vestibular function tests, through research on the multisensory temporal integration of balance senses.
[0062] To this end, with reference to FIG. 2, the stimulus input unit (110) can apply a plurality of different types of stimuli to sensory organs related to balance function under the control of the control unit (130) (S210).
[0063] The above-mentioned multiple stimuli of different types may include galvanic vestibular stimulation, visual stimulation, and vibrational stimulation.
[0064] The above galvanic vestibular stimulation can apply stimulation to the vestibular system, the above visual stimulation can apply stimulation to the visual system, and the above vibration stimulation can apply stimulation to the somatosensory system.
[0065] The dizziness cause identification device can set appropriate stimulation intensity and stimulation time for the inner ear vestibular system using galvanic vestibular stimulation.
[0066] The dizziness cause identification device can develop a vibrator to set appropriate stimulation intensity and time for the somatosensory system.
[0067] The dizziness cause identification device can set appropriate stimulation intensity and stimulation time for the visual system using VR goggles.
[0068] The control unit (130) can measure the time difference in which multiple stimuli are perceived in the cerebrum using a psychophysical method (S220).
[0069] The control unit (130) can measure the latency period until a human perceives the stimulus when galvanic stimulation, visual stimulation, or vibration stimulation is given using psychophysical research methods.
[0070] The control unit (130) can measure the time difference and accuracy of the three stimuli being integrated in the cerebrum.
[0071] The control unit (130) can analyze temporal integration in each of the three cases, which are combinations of two of the three stimuli—galvanic stimulation, visual stimulation, and vibration stimulation—using psychophysical methods to measure the main measurements, the temporal binding window (TBW) and the perceived subjective simultaneity (or Point of subjective simultaneity (PSS)).
[0072] The control unit (130) can control the stimulus input unit (110) to apply two stimuli among galvanic vestibular stimulation, visual stimulation, and vibration stimulation at predetermined time intervals.
[0073] The stimulation input unit (110) selects any two of galvanic vestibular stimulation, visual stimulation, and vibration stimulation, and applies the two selected stimulations multiple times at predetermined time intervals, and the predetermined time intervals can be varied by the control of the control unit (130).
[0074] For example, the control unit (130) may apply any two of the above stimuli (e.g., galvanic vestibular stimulation and visual stimulation) to the user at least once at a predetermined time interval (e.g., a difference of 200ms).
[0075] The control unit (130) can receive input from the user indicating that it has recognized that any two of the above stimuli have been applied.
[0076] Additionally, the control unit (130) may apply any two of the stimuli to the user at least once at different predetermined time intervals (e.g., a difference of 100ms), and in this case, may receive input from the user indicating that they have recognized that any two of the stimuli have been applied.
[0077] The control unit (130) can apply any two stimuli at a predetermined time interval (e.g., stimulus onset asynchronies, SOAs). This predetermined time interval can be varied such as time intervals of -200, -100, 0, +100, +200 (ms).
[0078] The control unit (130) can measure the time difference between the points in time when each stimulus is perceived for two stimuli that are applied multiple times at the predetermined time interval.
[0079] The control unit (130) can determine the Temporal Binding Window (TBW) and Perceived Subjective Simultaneity (PSS) based on the measured time difference (S230).
[0080] The control unit (130) can determine the Temporal Binding Window (TBW) and Perceived Subjective Simultaneity (PSS) based on a predetermined time interval between two stimuli and the time difference between the points in time when each stimulus is perceived.
[0081] The above time combination window is determined based on the perceived time difference relative to the above predetermined time interval (SOA), and the perceived subjective simultaneity may refer to the time interval that the user perceives as simultaneous in the determined time combination window.
[0082] For example, the time combination window may be determined as a range between predetermined time intervals where the time difference perceived by the user is less than or equal to a predetermined value, and may be determined as a range between predetermined time intervals (-100ms to +100ms).
[0083] The above-mentioned perceived subjective simultaneity can be determined by the median value of the time combination window.
[0084] The content determining the above time combination window and perceived subjective simultaneity may borrow from generally known information.
[0085] Afterwards, the control unit (130) can determine the cause of dizziness by analyzing the discrepancy in temporal integration based on at least one of the time combination window and the perceived subjective simultaneity (S240).
[0086] The present disclosure can measure the temporal binding window and perceived subjective simultaneity for three stimuli in patients with acute vestibular disease.
[0087] In addition, the present disclosure can measure the temporal binding width and perceived subjective simultaneity for three stimuli in patients with chronic subjective dizziness and patients with vestibular migraine.
[0088] In addition, the present disclosure can measure temporal binding width and perceived subjective simultaneity for patients with motion sickness.
[0089] Below, the method for analyzing temporal integration discrepancies and the method for determining the cause of dizziness are explained in more detail.
[0090] The control unit (130) can determine which organ has a problem with perception among galvanic vestibular stimulation, visual stimulation, and vibration stimulation when the measured time difference relative to a predetermined time interval for applying two stimuli is greater than or equal to a reference value.
[0091] Determining the organ with a cognitive problem using a predetermined time interval for applying two stimuli and a measured time difference can be understood as determining the organ with a cognitive problem based on at least one of a time combination window and perceived subjective synchronicity.
[0092] For example, if the time difference between galvanic vestibular stimulation and visual stimulation is greater than a reference value, the control unit (130) may determine that there is a problem with either galvanic vestibular stimulation or visual stimulation.
[0093] In this case, the control unit (130) can determine if the time difference is greater than or equal to a reference value by applying galvanic vestibular stimulation-vibration stimulation or visual stimulation-vibration stimulation to the user, and thereby determine that there is a problem with either galvanic vestibular stimulation or visual stimulation.
[0094] For example, if the time difference perceived by the user in galvanic vestibular stimulation-vibration stimulation is greater than a reference value, the control unit (130) may determine that there is a problem with the inner ear vestibular system that perceives the galvanic vestibular stimulation.
[0095] The control unit (130) can conduct a training program for the organ having a cognitive problem by using any one of galvanic vestibular stimulation, visual stimulation, and vibration stimulation to stimulate the organ having a cognitive problem.
[0096] For example, if the control unit (130) determines that there is a problem with the inner ear vestibular system responding to galvanic vestibular stimulation, it may apply a stimulus other than galvanic vestibular stimulation (visual stimulus or vibration stimulus) to provide a continuous training program to resolve the discrepancy in temporal integration.
[0097] This disclosure is a study on multi-sensory temporal integration, the first of its kind in Korea in the field of dizziness and balance medicine.
[0098] The present disclosure suggests that sensory mismatch through the vestibular system, visual system, and somatosensory system can be a cause of dizziness, and can contribute to identifying the cause of dizziness by comprehensively analyzing spatial integration mismatch and temporal integration mismatch.
[0099] According to the present disclosure, vestibular function tests can contribute to identifying the cause of chronic dizziness in which normal findings are observed.
[0100] In addition, the present disclosure may be applied to users with abnormal findings in vestibular function tests, and may also be applied to patients with motion sickness who frequently experience motion sickness.
[0101] By applying the present disclosure, a new diagnostic method can be developed for the evaluation and prognosis determination of patients with dizziness, and subsequent research can be conducted on exercise therapy capable of normalizing the temporal integration of abnormal sensations in patients with dizziness.
[0102] The steps of the method or algorithm described in connection with the embodiments of the present disclosure may be implemented directly in hardware, implemented as a software module executed by hardware, or implemented by a combination thereof. The software module may reside in RAM (Random Access Memory), ROM (Read Only Memory), EPROM (Erasable Programmable ROM), EEPROM (Electrically Erasable Programmable ROM), flash memory, a hard disk, a removable disk, a CD-ROM, or any form of computer-readable recording medium well known in the art to which the present invention belongs.
[0103] As described above, the disclosed embodiments have been explained with reference to the attached drawings. Those skilled in the art will understand that the present disclosure may be practiced in forms different from the disclosed embodiments without changing the technical spirit or essential features of the present disclosure. The disclosed embodiments are illustrative and should not be interpreted restrictively.
Claims
Claim 1 A method for determining an organ having a problem at the time of stimulus perception, performed by a device for determining an organ having a problem at the time of stimulus perception, comprising: a step of applying a plurality of different types of stimuli to a sensory organ related to balance function through a stimulus input unit of said device; a step of measuring the time difference of the stimulus perception time in the cerebrum by a psychophysical method through a control unit of said device; and a step of determining a time combination window and a perceived subjective synchronicity based on the measured time difference through said control unit. The method further includes a step of determining the cause of dizziness by analyzing the discrepancy in temporal integration based on the time combination window and perceived subjective synchronicity through the control unit, wherein the plurality of stimuli include galvanic vestibular stimulation, visual stimulation, and vibration stimulation, and the perceived subjective synchronicity is determined as the median value of the time interval that the user perceives as simultaneous in the time combination window; wherein, through the control unit, in a combination of two selected from the galvanic vestibular stimulation, the visual stimulation, and the vibration stimulation, if the measured time difference relative to a predetermined time interval for applying the two stimuli is greater than or equal to a preset reference value, the method further includes a step of analyzing which combination of the galvanic vestibular stimulation, visual stimulation, and vibration stimulation exhibits a value greater than or equal to the reference value, and determining which sense has an abnormality based on the result of the analysis; wherein the step of determining which sense has an abnormality includes, through the control unit, determining that there is a problem with the temporal integration of the sensory organs related to the balance function if the median value of the time interval that the user perceives as simultaneous is greater than or equal to a preset reference value, and through the control unit, determining that the problem with the temporal integration of the sensory organs related to the balance function A method characterized by conducting a training program for the inner ear vestibular system to resolve the discrepancy in temporal integration by applying the galvanic vestibular stimulation and the visual stimulation or the vibration stimulation when it is determined that such a discrepancy exists. Claim 2 A method according to claim 1, wherein the applying step is characterized by applying two of the galvanic vestibular stimulation, the visual stimulation, and the vibration stimulation at a predetermined time interval. Claim 3 A method according to claim 1, wherein the applying step comprises selecting two stimuli among the galvanic vestibular stimulation, the visual stimulation, and the vibration stimulation, applying the two selected stimuli multiple times at predetermined time intervals, and wherein the predetermined time intervals are variable. Claim 4 A method according to paragraph 3, wherein the measuring step is characterized by measuring the time difference between the points in time when each stimulus is perceived for two stimuli applied multiple times at a predetermined time interval. Claim 5 A method according to claim 1, characterized in that the galvanic vestibular stimulation applies stimulation to the vestibular system, the visual stimulation applies stimulation to the visual system, and the vibration stimulation applies stimulation to the somatosensory system. Claim 6 A stimulus input unit that applies multiple stimuli of different types to sensory organs related to balance function; The system includes a control unit that measures the time difference of the point of stimulus perception in the cerebrum of the plurality of stimuli using a psychophysical method, determines a time combination window and perceived subjective synchronicity based on the measured time difference, and determines the cause of dizziness by analyzing the discrepancy of temporal integration based on the time combination window and perceived subjective synchronicity, wherein the plurality of stimuli include galvanic vestibular stimulation, visual stimulation, and vibration stimulation, and the perceived subjective synchronicity is determined as the median value of the time interval that the user perceives as simultaneous in the time combination window, and wherein, in a combination of two selected from the galvanic vestibular stimulation, the visual stimulation, and the vibration stimulation, if the measured time difference relative to a predetermined time interval for applying the two stimuli is greater than or equal to a preset reference value, the control unit analyzes which combination of the galvanic vestibular stimulation, visual stimulation, and vibration stimulation exhibits a value greater than or equal to the reference value, and determines which sense is abnormal based on the result of the analysis, wherein when determining which sense is abnormal, if the median value of the time interval that the user perceives as simultaneous is greater than or equal to the preset reference value, the sense related to the balance function A device for determining an organ with a problem at the time of stimulus perception, characterized by determining that there is a problem with the temporal integration of the organ, and when it is determined that there is a problem with the temporal integration of the sensory organ related to the balance function, applying the galvanic vestibular stimulation and the visual stimulation or the vibration stimulation to resolve the discrepancy in the temporal integration and conducting a training program for the inner ear vestibular system. Claim 7 A device for determining an organ having a problem at the time of stimulus perception, wherein, in claim 6, the control unit applies two of the galvanic vestibular stimulus, the visual stimulus, and the vibration stimulus at a predetermined time interval. Claim 8 A device for determining an organ having a problem at the time of stimulus perception, characterized in that, in claim 6, the control unit selects two stimuli among the galvanic vestibular stimulation, the visual stimulation, and the vibration stimulation, applies the two selected stimuli multiple times at a predetermined time interval, and the predetermined time interval is variable. Claim 9 In claim 8, the control unit is characterized by measuring the time difference between the points of perception of each stimulus for two stimuli applied multiple times at a predetermined time interval, a device for determining an organ having a problem at the time of stimulus perception. Claim 10 A device for determining an organ with a problem at the time of stimulus perception, characterized in that, in claim 6, the galvanic vestibular stimulation applies stimulation to the vestibular system, the visual stimulation applies stimulation to the visual system, and the vibration stimulation applies stimulation to the somatosensory system.
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