Tubulysin derivatives
MA39862AUndetermined Publication Date: 2017-02-15GINGIPALLI LAKSHMAIAH +3
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Patent Information
- Application Number
- MA39862
- Authority / Receiving Office
- MA · MA
- Patent Type
- Applications
- Current Assignee / Owner
- Priority Date
- 2014-04-11
- Filing Date
- 2015-04-10
- Publication Date
- 2017-02-15
Abstract
Novel tubulysin derivatives which may be useful as cytotoxic agents to provide therapeutic benefits in the treatment of various types of cancers, alone or as drug conjugates with antibodies are provided. The tubulysin derivatives consist of a tetrapeptide scaffold comprising methyl and ethyl substituted piperidines. The tubulysin conjugates further comprise monoclonal antibody via succinimide linkers.
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