Methods for treating inflammatory bowel disease

Abstract

Methods of treating a subject with ibd with an anti-smad7 therapy,such as a smad7 antisense oligonucleotide, to reduce crp levels are disclosed. Methods of treating and managing ibd in a subject using an anti-smad7 therapy, such as a smad7 antisense oligonucleotide, based on crp levels are also disclosed. Also disclosed are methods of determining whether a subject with ibd is responsive or likely to be responsive to treatment an anti-smad7 therapy. Reduction of crp levels may correlated with ibd remission or decreases in cdai score.The present invention also relates to treatment of ibd using an anti-smad7 therapy (e.G., an antisense oligonucleotide) in combination with an additional agent. The invention also features related pharmaceutical compositions and kits.