Combinations for treating cancers

Abstract

Disclosed are combinations for treating a cancer in a subject (e.G., a human) in need thereof, comprising a therapeutically effective amount of a compound of formula (i): or a pharmaceutically acceptable salt thereof, and a vinca-alkaloid, or a pharmaceutically acceptable salt thereof. The subject may be very high risk or high risk for the cancer and may not respond to either agent administered as a sole therapy. The subject who has the cancer may also be refractory to at least one chemotherapy treatment, or is in relapse after treatment with chemotherapy, or both. The cancer may be a hematologic malignancy, such as leukemia or lymphoma, or a solid tumor cancer, such as pancreatic, lung and colon cancer.